CN105943728A - Traditional Chinese medicine unguent for treating knee pain and preparing method and application thereof - Google Patents
Traditional Chinese medicine unguent for treating knee pain and preparing method and application thereof Download PDFInfo
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- CN105943728A CN105943728A CN201610403635.5A CN201610403635A CN105943728A CN 105943728 A CN105943728 A CN 105943728A CN 201610403635 A CN201610403635 A CN 201610403635A CN 105943728 A CN105943728 A CN 105943728A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention discloses traditional Chinese medicine unguent for treating knee pain and a preparing method and application thereof. The traditional Chinese medicine unguent is prepared from, by weight, 5-12 parts of herba gynura bicolor, 20-28 parts of fructus canarli, 3-10 parts of herba viola philippica, 10-18 parts of herba pteridis multifidae and 16-24 parts of ricepaperplant root. The preparing method includes the steps that fructus canarli and herba viola philippica are smashed and screened, 50% ethanol solution is added, the mixture is heated, stirred, treated with microwaves, and filtered to obtain filter liquor A; herba pteridis multifidae and ricepaperplant root are smashed and screened, salt water solution is added, the mixture is heated, stirred and filtered to obtain filter liquor B; herba gynura bicolor is smashed and screened, vinegar is added, the mixture is heated to obtain a herba gynura bicolor pretreatment material; the filter liquor A and the herba gynura bicolor pretreatment material are mixed and treated ultrasonically, then the filter liquor B is added, the obtained mixture is treated ultrasonically to obtain the traditional Chinese medicine unguent. The traditional Chinese medicine unguent has the advantages of being definite in curative effect, safe, free of side effects, capable of achieving ideal curative effect, easy to prepare, low in cost, convenient to use and short in cure time and taking effect fast, and knee pain is not prone to relapse after being cure.
Description
Technical field
The present invention relates to pharmaceutical technology field, a kind of Chinese medicinal ointment treating the gonalgia and preparation method thereof and should
With.
Background technology
Arthralgia causes mainly due to arthritis or arthrosis.Produce gonarthritis, the common knee joint such as synovitis
Inflammation.Arthritis is a kind of common with autoimmune disease that joint tissue chronic inflammatory disease is main performance.Pathological changes joint
Mainly show as inflammatory cell infiltration, the formation of synovial hyperplasia, pannus and the cartilage thus caused and the damage of bone.Joint
Scorching genus Chinese medicine " numbness is sick " category."Nei Jing" is thought, ferritic deficiency of qi and blood, and wind, cold, wet three gas heterozygosis is taken advantage of a weak point in opponent's defence and invaded
Human body, multiple abscess muscles and bones blood vessels, fight and tie in joint, be the Etiological pathogenesis of numbness disease.So, the heresy that wind and cold is damp and hot is this
Pathogenetic external condition, and insufficiency of vital energy and blood, battalion defends imbalance and is only the intrinsic factor of primary disease.Treatment primary disease is when with expelling wind and cold
Dehumidifying, benefiting QI for activating blood circulation dredging collateral is rule for the treatment of.Knee has many synovial bursas relevant with joint motion and tendon slide construction, have with
Joint communicates, and have then isolated exists, and the most ill synovial bursa is prepatellar bursa, and synovial bursa gastrocnemius under kneecap, knee are long
The external force friction of phase or compressing, all may result in that synovial membrane is congested, edema and serosity ooze out, and forms acute synovial bursa hydrops, cyst wall
Thicken and the pathological changes such as joint accretion.The synovial layer blood fortune of capsula articularis genus is abundant, and distribution is relatively big, is kneed heavy
Want one of structure.Therapeutic Method the most oral anti-inflammatory analgesic, plaster, massage etc..But oral anti-inflammatory analgesic is secondary
Effect is big, naturopathy, massage weak effect, prolonged do not heal, the course of disease extends, and brings great financial burden to patient
Individual psychic pain.Existing plaster weak curative effect, course of disease time lengthening, it is difficult to cure, recurrent exerbation.
Summary of the invention
It is an object of the invention to provide a kind of determined curative effect, instant effect, the treatment gonalgia safe and free of toxic and side effects
Chinese medicinal ointment and its preparation method and application, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicinal ointment treating the gonalgia, is made up of according to the raw material of weight portion following: Radix Semiaquilegiae 5-12 part, green grass or young crops
Really 20-28 part, Herba Violae mundae 3-10 part, Herba Pteridis Multifidae 10-18 part, Radix tetrapanacis Koch 16-24 part.
As the further scheme of the present invention: the Chinese medicinal ointment of the described treatment gonalgia, by the following raw material according to weight portion
Composition: Radix Semiaquilegiae 7-10 part, Fructus Canarii 22-26 part, Herba Violae mundae 5-8 part, Herba Pteridis Multifidae 12-16 part, Radix tetrapanacis Koch 18-22
Part.
As the further scheme of the present invention: the Chinese medicinal ointment of the described treatment gonalgia, by the following raw material according to weight portion
Composition: Radix Semiaquilegiae 8 parts, Fructus Canarii 24 parts, Herba Violae mundae 7 parts, Herba Pteridis Multifidae 14 parts, Radix tetrapanacis Koch 20 parts.
It is a further object of the present invention to provide the preparation method of a kind of Chinese medicinal ointment treating the gonalgia, by following steps group
Become:
1) Fructus Canarii, Herba Violae mundae are pulverized, crossed 100 mesh sieves, add 50% ethanol solution of the two quality 6-7 times, at 52-55
Being stirred 40-45min at DEG C, then carry out microwave treatment 30-35min, microwave power is 800W, takes filter after filtration
Liquid A；
2) Herba Pteridis Multifidae, Radix tetrapanacis Koch are pulverized, crossed 120 mesh sieves, add the food that salt content is 3-5% of its quality 4-5 times
Saline solution, at a temperature of 82-85 DEG C, heated and stirred processes 80-90min, crosses leaching liquor B；
3) Radix Semiaquilegiae pulverized, cross 200 mesh sieves, add the vinegar of its quality 0.5-0.8 times, be incubated at 65-68 DEG C
30-40min, then at 110-115 DEG C, toast 25-30min, prepare Radix Semiaquilegiae pretreatment material；
4) filtrate A is mixed with Radix Semiaquilegiae pretreatment material, supersound process 20-25min at a temperature of 65-68 DEG C, then add
Enter liquor B supersound process 35-40min, then at a temperature of 75-78 DEG C stir process until water content 5-8% i.e. obtains Chinese medicinal ointment.
A further object of the present invention is the application in preparation treatment gonalgia medicine of the described Chinese medicinal ointment.
Rich in flavonoid glycoside composition in Radix Semiaquilegiae Radix Semiaquilegiae, ascorbic effect can be extended, reduce blood vessel purpura.Purple
Back of the body Radix Semiaquilegiae can improve the ability of parasiticide and antiviral, has certain preventive effect to tumor.Also there is treatment hemoptysis, metrorrhagia, bitterly
Effect of the diseases such as warp, bronchitis, pelvic inflammatory disease and iron deficiency anemia.
Fructus Canarii has heat-clearing and toxic substances removing, and sore-throat relieving reduces phlegm, promoting the production of body fluid to quench thirst, and whet the appetite sending down the abnormal ascending QI, and effect of relieving restlessness relieving alcoholic intoxication is adapted to control pharynx
The diseases such as larynx swells and ache, and cough is spitted blood, bacillary dysentery, epilepsy, summer-heat excessive thirst, enteritis, diarrhea.
Herba Violae mundae dissipates wind, and heat clearing away is soothing the liver, detumescence.Controlling wind-fire acute conjunctivitis, corneal nebula hides eyeball, acute mastitis, scrofula, and furuncle swells.
Herba Pteridis Multifidae has the effects such as clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating, is used for treating dysentery, enteritis, icteric liver
Scorching, spit blood, have blood in stool, the disease such as hematuria.
Radix tetrapanacis Koch has clearing away heat and promoting diuresis, circulation of qi promoting helps digestion, the effect of stimulating milk secretion of invigorating blood circulation.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention uses pure traditional Chinese medicine to form, have under the synergism of each raw material determined curative effect, instant effect, safety,
The feature such as have no side effect, and has bone and muscle strengthening, invigorating the liver and kidney, makes local vascular dilation, blood fortune strengthen, and metabolism strengthens, immunity
Power improves, so that pain relief, promotes the absorption of blood stasis, plays relaxing muscles and tendons and activating QI and blood in the collateral, consolidates eliminating evil, the effect of reducing swelling and alleviating pain.
The present invention has the strongest medicine penetration capacity, cures curative effect far above common cream note.The present invention uses the Chinese medicine of different properties
Material, has carried out scientific compatibility, can reach preferable therapeutic effect, safety, have no side effect, it is easy to manufacture, with low cost,
Easy to use, healing time is short, controls difficulty in relapse after healing.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, aobvious
So, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicinal ointment treating the gonalgia, it is made up of according to the raw material of weight portion following: purple
The back of the body Radix Semiaquilegiae 5 parts, Fructus Canarii 20 parts, Herba Violae mundae 3 parts, Herba Pteridis Multifidae 10 parts, Radix tetrapanacis Koch 16 parts.
Fructus Canarii, Herba Violae mundae are pulverized, crossed 100 mesh sieves, adds 50% ethanol solution of the two quality 6 times, enter at 52 DEG C
Row stir process 40min, then carry out microwave treatment 30min, microwave power is 800W, takes filtrate A after filtration.By phoenix tail
Grass, Radix tetrapanacis Koch are pulverized, are crossed 120 mesh sieves, add the common salt aqueous solution that salt content is 3% of its quality 4 times, at 82 DEG C
At a temperature of heated and stirred process 80min, cross leaching liquor B.Radix Semiaquilegiae is pulverized, crosses 200 mesh sieves, add its matter
Measure the vinegar of 0.5 times, at 65 DEG C, be incubated 30min, then at 110 DEG C, toast 25min, prepare Radix Semiaquilegiae pretreatment material.
Filtrate A is mixed with Radix Semiaquilegiae pretreatment material, supersound process 20min at a temperature of 65 DEG C, add liquor B ultrasonic
Process 35min, then at a temperature of 75 DEG C stir process until water content 5% i.e. obtains Chinese medicinal ointment.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicinal ointment treating the gonalgia, it is made up of according to the raw material of weight portion following: purple
The back of the body Radix Semiaquilegiae 12 parts, Fructus Canarii 28 parts, Herba Violae mundae 10 parts, Herba Pteridis Multifidae 18 parts, Radix tetrapanacis Koch 24 parts.
Fructus Canarii, Herba Violae mundae are pulverized, crossed 100 mesh sieves, adds 50% ethanol solution of the two quality 7 times, enter at 55 DEG C
Row stir process 45min, then carry out microwave treatment 35min, microwave power is 800W, takes filtrate A after filtration.By phoenix tail
Grass, Radix tetrapanacis Koch are pulverized, are crossed 120 mesh sieves, add the common salt aqueous solution that salt content is 5% of its quality 5 times, at 85 DEG C
At a temperature of heated and stirred process 90min, cross leaching liquor B.Radix Semiaquilegiae is pulverized, crosses 200 mesh sieves, add its matter
Measure the vinegar of 0.8 times, at 68 DEG C, be incubated 40min, then at 115 DEG C, toast 30min, prepare Radix Semiaquilegiae pretreatment material.
Filtrate A is mixed with Radix Semiaquilegiae pretreatment material, supersound process 25min at a temperature of 68 DEG C, add liquor B ultrasonic
Process 40min, then at a temperature of 78 DEG C stir process until water content 8% i.e. obtains Chinese medicinal ointment.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicinal ointment treating the gonalgia, it is made up of according to the raw material of weight portion following: purple
The back of the body Radix Semiaquilegiae 7 parts, Fructus Canarii 22 parts, Herba Violae mundae 5 parts, Herba Pteridis Multifidae 12 parts, Radix tetrapanacis Koch 18 parts.
Fructus Canarii, Herba Violae mundae are pulverized, crossed 100 mesh sieves, adds 50% ethanol solution of the two quality 6.5 times, at 54 DEG C
Being stirred 42min, then carry out microwave treatment 32min, microwave power is 800W, takes filtrate A after filtration.By phoenix
Tail grass, Radix tetrapanacis Koch are pulverized, are crossed 120 mesh sieves, add the common salt aqueous solution that salt content is 4% of its quality 4.5 times,
At a temperature of 83 DEG C, heated and stirred processes 85min, crosses leaching liquor B.Radix Semiaquilegiae is pulverized, crosses 200 mesh sieves, add
The vinegar of its quality 0.6 times, is incubated 35min at 67 DEG C, then toasts 28min at 112 DEG C, and prepared Radix Semiaquilegiae is located in advance
Reason material.Filtrate A is mixed with Radix Semiaquilegiae pretreatment material, supersound process 22min at a temperature of 67 DEG C, add filtrate
B ultrasonic sonication 38min, then at a temperature of 76 DEG C stir process until water content 6% i.e. obtains Chinese medicinal ointment.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicinal ointment treating the gonalgia, it is made up of according to the raw material of weight portion following: purple
The back of the body Radix Semiaquilegiae 10 parts, Fructus Canarii 26 parts, Herba Violae mundae 8 parts, Herba Pteridis Multifidae 16 parts, Radix tetrapanacis Koch 22 parts.
Fructus Canarii, Herba Violae mundae are pulverized, crossed 100 mesh sieves, adds 50% ethanol solution of the two quality 6.5 times, at 54 DEG C
Being stirred 42min, then carry out microwave treatment 32min, microwave power is 800W, takes filtrate A after filtration.By phoenix
Tail grass, Radix tetrapanacis Koch are pulverized, are crossed 120 mesh sieves, add the common salt aqueous solution that salt content is 4% of its quality 4.5 times,
At a temperature of 83 DEG C, heated and stirred processes 85min, crosses leaching liquor B.Radix Semiaquilegiae is pulverized, crosses 200 mesh sieves, add
The vinegar of its quality 0.6 times, is incubated 35min at 67 DEG C, then toasts 28min at 112 DEG C, and prepared Radix Semiaquilegiae is located in advance
Reason material.Filtrate A is mixed with Radix Semiaquilegiae pretreatment material, supersound process 22min at a temperature of 67 DEG C, add filtrate
B ultrasonic sonication 38min, then at a temperature of 76 DEG C stir process until water content 6% i.e. obtains Chinese medicinal ointment.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicinal ointment treating the gonalgia, it is made up of according to the raw material of weight portion following: purple
The back of the body Radix Semiaquilegiae 8 parts, Fructus Canarii 24 parts, Herba Violae mundae 7 parts, Herba Pteridis Multifidae 14 parts, Radix tetrapanacis Koch 20 parts.
Fructus Canarii, Herba Violae mundae are pulverized, crossed 100 mesh sieves, adds 50% ethanol solution of the two quality 6.5 times, at 54 DEG C
Being stirred 42min, then carry out microwave treatment 32min, microwave power is 800W, takes filtrate A after filtration.By phoenix
Tail grass, Radix tetrapanacis Koch are pulverized, are crossed 120 mesh sieves, add the common salt aqueous solution that salt content is 4% of its quality 4.5 times,
At a temperature of 83 DEG C, heated and stirred processes 85min, crosses leaching liquor B.Radix Semiaquilegiae is pulverized, crosses 200 mesh sieves, add
The vinegar of its quality 0.6 times, is incubated 35min at 67 DEG C, then toasts 28min at 112 DEG C, and prepared Radix Semiaquilegiae is located in advance
Reason material.Filtrate A is mixed with Radix Semiaquilegiae pretreatment material, supersound process 22min at a temperature of 67 DEG C, add filtrate
B ultrasonic sonication 38min, then at a temperature of 76 DEG C stir process until water content 6% i.e. obtains Chinese medicinal ointment.
Comparative example 1
In addition to not containing Radix tetrapanacis Koch, its formula and preparation process are consistent with embodiment 5.
Comparative example 2
Containing only Radix tetrapanacis Koch, its preparation process is consistent with embodiment 5.
Embodiment 6 pharmacological toxicity is tested
Skin peptide irritation test
Take rabbit shaving, carry out inducing and exciting contact test by Chinese medicinal ointment of the present invention, observe behind 24 hours and 48 hours
Experimental rabbits, all loseing skin has the phenomenon such as erythema and edema, with negative control group zero difference.Result shows, this Chinese medicinal ointment
Dermoreaction intensity is bordering on zero, i.e. without skin allergic reaction.
Embodiment 7 clinical trial
One, clinical observation on the therapeutic effect test
1, case: gonalgia patient 400 example, wherein, man: 220, female: 180；1 month course of disease time～10 years
Above, be randomly divided into 8 groups, be respectively treatment 1 group, treat 2 groups, treat 3 groups, treat 4 groups, treat 5 groups, right
Than 1 group, contrast 2 groups, contrast 3 groups, often organize 50 examples.
2, Therapeutic Method
Treating 1 group of Chinese medicinal ointment selecting above-described embodiment 1, Chinese medicinal ointment consumption is 5g, Chinese medicinal ointment is attached at pain spot, repeatedly
Till being labelled to without Chinese medicinal ointment.
Treating 2 groups of Chinese medicinal ointment selecting above-described embodiment 2, Chinese medicinal ointment consumption is 5g, Chinese medicinal ointment is attached at pain spot, repeatedly
Till being labelled to without Chinese medicinal ointment.
Treating 3 groups of Chinese medicinal ointment selecting above-described embodiment 3, Chinese medicinal ointment consumption is 5g, medical ointment plaster at pain spot, repeatedly pastes
To without Chinese medicinal ointment.
Treating 4 groups of Chinese medicinal ointment selecting above-described embodiment 4, Chinese medicinal ointment consumption is 5g, medical ointment plaster at pain spot, repeatedly pastes
To without Chinese medicinal ointment.
Treating 5 groups of Chinese medicinal ointment selecting above-described embodiment 5, Chinese medicinal ointment consumption is 5g, medical ointment plaster at pain spot, repeatedly pastes
To without Chinese medicinal ointment.
Contrasting 1 group of Chinese medicinal ointment selecting above-mentioned comparative example 1, Chinese medicinal ointment consumption is 5g, medical ointment plaster at pain spot, repeatedly pastes
To without Chinese medicinal ointment.
Contrasting 2 groups of Chinese medicinal ointment selecting above-mentioned comparative example 2, Chinese medicinal ointment consumption is 5g, medical ointment plaster at pain spot, repeatedly pastes
To without Chinese medicinal ointment.
Contrast 3 groups of Chinese medicinal ointment selected on common market, medical ointment plaster at pain spot, till being repeatedly labelled to without Chinese medicinal ointment.
3, criterion of therapeutical effect:
Cure: pain disappears, and function of joint is normal；
Effective: pain disappears, function of joint is improved；
Effective: pain relief, function of joint obtains part and improves；
Invalid: the same with symptom before treatment.
4, therapeutic effect
Over the course for the treatment of, patient's knee joint distending pain is decreased obviously, and knee joint function is greatly improved, and uses 7 days
After concrete condition refer to table 1.
Table 1 gonalgia patient's observation of curative effect table
| Group | n | Cure | Effective | Effectively | Invalid | Cure rate % | Total effective rate % |
| Treat 1 group | 50 | 38 | 3 | 8 | 1 | 76 | 98 |
| Treat 2 groups | 50 | 39 | 4 | 7 | 0 | 78 | 100 |
| Treat 3 groups | 50 | 44 | 2 | 2 | 0 | 88 | 100 |
| Treat 4 groups | 50 | 45 | 1 | 4 | 0 | 90 | 100 |
| Treat 5 groups | 50 | 48 | 2 | 0 | 0 | 96 | 100 |
| Contrast 1 group | 50 | 3 | 7 | 24 | 16 | 6 | 68 |
| Contrast 2 groups | 50 | 0 | 1 | 8 | 41 | 0 | 18 |
| Contrast 3 groups | 50 | 12 | 8 | 22 | 8 | 24 | 84 |
As can be seen from the above table, in above-mentioned treatment, after treating 7 days, cure rate more than 75% of the present invention；Total effective rate
Reach more than 98%；Illustrate that the Chinese medicinal ointment of the present invention has effect of blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain, to knee joint
Pain has good therapeutical effect, and curative effect is fast, and effective percentage is high, has no side effect, and safety is good.By contrast 1-2 group
With treat 5 groups compare understand, the present invention is to play the highest curative effect under the synergism of each raw material.
Model case:
1, Wang, man, 48 years old, right knee joint injury one month.Right knee joint swelling, hurt like hell, it is impossible to walking,
When going down on one's knees, pain increases the weight of, and station swelling is obvious for a long time, is checking: periarticular swelling, medial collateral ligament tenderness, and Xiyan swells and pain,
Patella reflex is hyperfunction.Use the Chinese medicinal ointment of the embodiment of the present invention 4, fully recover after 7 days.Follow up a case by regular visits to 1 year, recur the most again.
2, Zhang, man, 52 years old, the right gonalgia 7 years, acute attack 2 days.Hurt like hell, the most not peaceful, from
Taking analgesic, effect does not shows.Use the Chinese medicinal ointment of the embodiment of the present invention 5, fully recover after 7 days.Follow up a case by regular visits to 1 year, recur the most again.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and do not carrying on the back
In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from
From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim
Change is included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only comprises
One independent technical scheme, this narrating mode of description is only the most for clarity sake, and those skilled in the art should be by
Description is as an entirety, and the technical scheme in each embodiment can also be through appropriately combined, and forming those skilled in the art can
With other embodiments understood.
Claims (5)
1. the Chinese medicinal ointment treating the gonalgia, it is characterised in that be made up of according to the raw material of weight portion following: the purple back of the body
Radix Semiaquilegiae 5-12 part, Fructus Canarii 20-28 part, Herba Violae mundae 3-10 part, Herba Pteridis Multifidae 10-18 part, Radix tetrapanacis Koch 16-24 part.
The Chinese medicinal ointment of the treatment gonalgia the most according to claim 1, it is characterised in that by following according to weight portion
Raw material composition: Radix Semiaquilegiae 7-10 part, Fructus Canarii 22-26 part, Herba Violae mundae 5-8 part, Herba Pteridis Multifidae 12-16 part, Radix tetrapanacis Koch
18-22 part.
The Chinese medicinal ointment of the treatment gonalgia the most according to claim 1, it is characterised in that by following according to weight portion
Raw material composition: Radix Semiaquilegiae 8 parts, Fructus Canarii 24 parts, Herba Violae mundae 7 parts, Herba Pteridis Multifidae 14 parts, Radix tetrapanacis Koch 20 parts.
4. the preparation method of the Chinese medicinal ointment of the treatment gonalgia as described in claim 1-3 is arbitrary, it is characterised in that
Comprise the steps of:
1) Fructus Canarii, Herba Violae mundae are pulverized, crossed 100 mesh sieves, add 50% ethanol solution of the two quality 6-7 times, at 52-55
Being stirred 40-45min at DEG C, then carry out microwave treatment 30-35min, microwave power is 800W, takes filter after filtration
Liquid A；
2) Herba Pteridis Multifidae, Radix tetrapanacis Koch are pulverized, crossed 120 mesh sieves, add the food that salt content is 3-5% of its quality 4-5 times
Saline solution, at a temperature of 82-85 DEG C, heated and stirred processes 80-90min, crosses leaching liquor B；
3) Radix Semiaquilegiae pulverized, cross 200 mesh sieves, add the vinegar of its quality 0.5-0.8 times, be incubated at 65-68 DEG C
30-40min, then at 110-115 DEG C, toast 25-30min, prepare Radix Semiaquilegiae pretreatment material；
4) filtrate A is mixed with Radix Semiaquilegiae pretreatment material, supersound process 20-25min at a temperature of 65-68 DEG C, then add
Enter liquor B supersound process 35-40min, then at a temperature of 75-78 DEG C stir process until water content 5-8% i.e. obtains Chinese medicinal ointment.
5. the application in preparation treatment gonalgia medicine of the Chinese medicinal ointment as described in claim 1-3 is arbitrary.
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| CN1546119A (en) * | 2003-12-12 | 2004-11-17 | 孙立明 | Externally applied plaster for treating knee-joint pain caused by wind dampness |
| CN101642548A (en) * | 2009-08-27 | 2010-02-10 | 吴清玲 | Traditional Chinese medicine patch for treating loin and leg pain and preparation method thereof |
| CN101897890A (en) * | 2009-05-27 | 2010-12-01 | 贠钦亮 | Chinese medicinal ointment for treating arthralgia and osteopatia sprain |
| CN103463580A (en) * | 2013-09-24 | 2013-12-25 | 韦成旺 | Chinese medicine ointment for treating pain of muscles, bones and joints and preparation method thereof |
| CN105381098A (en) * | 2015-10-21 | 2016-03-09 | 王善荣 | Traditional Chinese medicine fumigating and washing agent for treating knee osteoarthritis and nursing method |
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|---|---|---|---|---|
| CN1546119A (en) * | 2003-12-12 | 2004-11-17 | 孙立明 | Externally applied plaster for treating knee-joint pain caused by wind dampness |
| CN101897890A (en) * | 2009-05-27 | 2010-12-01 | 贠钦亮 | Chinese medicinal ointment for treating arthralgia and osteopatia sprain |
| CN101642548A (en) * | 2009-08-27 | 2010-02-10 | 吴清玲 | Traditional Chinese medicine patch for treating loin and leg pain and preparation method thereof |
| CN103463580A (en) * | 2013-09-24 | 2013-12-25 | 韦成旺 | Chinese medicine ointment for treating pain of muscles, bones and joints and preparation method thereof |
| CN105381098A (en) * | 2015-10-21 | 2016-03-09 | 王善荣 | Traditional Chinese medicine fumigating and washing agent for treating knee osteoarthritis and nursing method |
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