CN105943087B - The image processing method and processing system of ultrasonic microbubble cavitation device - Google Patents

The image processing method and processing system of ultrasonic microbubble cavitation device Download PDF

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Publication number
CN105943087B
CN105943087B CN201610591033.7A CN201610591033A CN105943087B CN 105943087 B CN105943087 B CN 105943087B CN 201610591033 A CN201610591033 A CN 201610591033A CN 105943087 B CN105943087 B CN 105943087B
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China
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scanning
microvesicle
acoustic pressure
imaging region
zone
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CN201610591033.7A
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Chinese (zh)
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CN105943087A (en
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陈惠人
凌涛
高顺记
刘政
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飞依诺科技(苏州)有限公司
刘政
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Abstract

The present invention provides the image processing method and processing system of a kind of ultrasonic microbubble cavitation device, the treating method comprises: obtaining imaging region and microvesicle cavitation zone;The control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone is configured respectively;The control parameter of the scanning acoustic pressure includes: tranmitting frequency, and emitting voltage emits pulse length, emits pulse recurrence frequency, emits pulse mode and line density;In predetermined interval, pass through the control parameter timesharing independent scan imaging region or microvesicle cavitation zone of respective scanning acoustic pressure.The image processing method and processing system of ultrasonic microbubble cavitation device of the invention, by dividing different regions and preset corresponding parameter, it can so that ultrasonic microbubble cavitation device is had two kinds of functions, realize simple, saving manufacture and use cost.

Description

The image processing method and processing system of ultrasonic microbubble cavitation device

Technical field

The invention belongs to medical ultrasound technical fields, relate generally to a kind of image processing method of ultrasonic microbubble cavitation device And processing system.

Background technique

Ultrasonic imaging becomes clinically because its is non-invasive, real-time, many advantages such as easy to operate, cheap One of means of auxiliary diagnosis being most widely used.

Ultrasonic microbubble cavitation technique is a kind of emerging technology, is currently in the high speed development stage, is manufactured using the technology Ultrasonic microbubble equipment for treating the diseases such as tumour.

In the prior art, since ultrasonic imaging and ultrasonic microbubble cavitation treatment demand are runed counter to, it may be assumed that under ultrasonic imaging state, Need to reduce to the greatest extent the breakage of microvesicle to increase the intensity of nonlinear echoes and the duration of microvesicle itself, and in ultrasonic microbubble Under the conditions of cavitation treatment, contrast agent microbubble transient cavitation or inertial cavitation are needed, the cavitation biology generated by the implosion of microvesicle Effect achievees the purpose that treatment, in this way, the same equipment cannot be used to carry out diagnosing and treating simultaneously.

Summary of the invention

The purpose of the present invention is to provide the image processing methods and processing system of a kind of ultrasonic microbubble cavitation device.

One of in order to achieve the above-mentioned object of the invention, the imaging of the ultrasonic microbubble cavitation device of an embodiment of the present invention Method the described method comprises the following steps: obtain imaging region and microvesicle cavitation zone;

The control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone is configured respectively;

The control parameter of the scanning acoustic pressure includes: tranmitting frequency, and emitting voltage emits pulse length, emits pulse weight Complex frequency emits pulse mode and line density;

In predetermined interval, by the control parameter timesharing independent scan imaging region of respective scanning acoustic pressure or micro- Steep cavitation zone.

As the further improvement of an embodiment of the present invention, " respectively to the scanning of imaging region and microvesicle cavitation zone The control parameter of acoustic pressure is configured " it specifically includes:

The ultrasonic microbubble cavitation is preset according to the size and location of the imaging region and the microvesicle cavitation zone to set Standby scanning acoustic pressure;The scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure;

Wherein, the imaging scanning acoustic pressure is lower than the microvesicle cavitation scanning acoustic pressure.

As the further improvement of an embodiment of the present invention, the control parameter of the imaging scanning acoustic pressure of the imaging region It specifically includes:

The section of the tranmitting frequency are as follows: 1.7-5.0MHz;

The section of the emitting voltage are as follows: 5.0-12.0V;

The section of the transmitting pulse length are as follows: 1-3 period;

The section of the transmitting pulse recurrence frequency are as follows: 10-30Hz;

The transmitting pulse mode: impulse ejection at least twice;

The distribution density of the line density of the imaging region is less than the line density of the microvesicle cavitation zone;

The control parameter of the microvesicle cavitation scanning acoustic pressure of the microvesicle cavitation zone specifically includes:

The section of the tranmitting frequency are as follows: 1.0-6.3MHz;

The section of the emitting voltage are as follows: 10.0-20.0V;

The section of the transmitting pulse length are as follows: 1-50 period;

The section of the transmitting pulse recurrence frequency are as follows: 10-100Hz;

The transmitting pulse mode: single or multiple impulse ejections;

The line density of the microvesicle cavitation zone is greater than the line density of the imaging region.

As the further improvement of an embodiment of the present invention, " in predetermined interval, pass through respective scanning sound The control parameter independent scan imaging region or microvesicle cavitation zone of pressure " specifically includes:

Judge whether the attribute of current scanning zone changes,

It includes: that imaging region is transitioned into microvesicle cavitation zone that transformation, which occurs, for the current scanning zone attribute;Or it is micro- Bubble cavitation zone is transitioned into imaging region;

If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, the control of scanning acoustic pressure is adjusted Parameter adaptation microvesicle cavitation zone processed automatically switches probe and arrives microvesicle after the completion of the control parameter adjustment of the scanning acoustic pressure Cavitation zone is scanned;

And restart timing, the microvesicle cavitation zone scanning duration is recorded, judges the microvesicle cavitation zone scanning Whether the duration is equal to the first preset threshold of system;

If so, stopping scanning microvesicle cavitation zone, the control parameter of adjustment scanning acoustic pressure adapts to imaging region, sweeps when described It looks into after the completion of the control parameter adjustment of acoustic pressure, automatically switches probe and be scanned to imaging region;

If it is not, continuing scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning duration;

If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone;

The control parameter for then adjusting scanning acoustic pressure adapts to imaging region, completes when the control parameter of the scanning acoustic pressure adjusts Afterwards, automatically switch probe to be scanned to imaging region;

Imaging region and microvesicle cavitation zone are reacquired according to the scanning result of the imaging region, and is adjusted described super The control parameter of the scanning acoustic pressure of sound microvesicle cavitation device.

As the further improvement of an embodiment of the present invention, the method also includes:

The system first is adjusted according to the transmitting pulse mode of the microvesicle cavitation zone and transmitting pulse recurrence frequency Preset threshold.

One of in order to achieve the above-mentioned object of the invention, an embodiment of the present invention provide a kind of ultrasonic microbubble cavitation device at Picture processing system, the system comprises: data acquisition module, for obtaining imaging region and microvesicle cavitation zone;

Data processing module, the control parameter for the scanning acoustic pressure respectively to imaging region and microvesicle cavitation zone carry out Setting;The control parameter of the scanning acoustic pressure includes: tranmitting frequency, and emitting voltage emits pulse length, and transmitting pulse repeats frequency Rate emits pulse mode and line density;

In predetermined interval, by the control parameter timesharing independent scan imaging region of respective scanning acoustic pressure or micro- Steep cavitation zone.

As the further improvement of an embodiment of the present invention, the data processing module is specifically used for: according to it is described at As the size and location in region and the microvesicle cavitation zone preset the scanning acoustic pressure of the ultrasonic microbubble cavitation device;It is described to sweep Looking into acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure.

As the further improvement of an embodiment of the present invention, the control parameter of the imaging scanning acoustic pressure of the imaging region It specifically includes:

The section of the tranmitting frequency are as follows: 1.7-5.0MHz;

The section of the emitting voltage are as follows: 5.0-12.0V;

The section of the transmitting pulse length are as follows: 1-3 period;

The section of the transmitting pulse recurrence frequency are as follows: 10-30Hz;

The transmitting pulse mode: impulse ejection at least twice;

The distribution density of the line density of the imaging region is less than the line density of the microvesicle cavitation zone;

The control parameter of the microvesicle cavitation scanning acoustic pressure of the microvesicle cavitation zone specifically includes:

The section of the tranmitting frequency are as follows: 1.0-6.3MHz;

The section of the emitting voltage are as follows: 10.0-20.0V;

The section of the transmitting pulse length are as follows: 1-50 period;

The section of the transmitting pulse recurrence frequency are as follows: 10-100Hz;

The transmitting pulse mode: single or multiple impulse ejections;

The line density of the microvesicle cavitation zone is greater than the line density of the imaging region.

As the further improvement of an embodiment of the present invention, the data processing module is specifically used for:

Judge whether the attribute of current scanning zone changes,

It includes: that imaging region is transitioned into microvesicle cavitation zone that transformation, which occurs, for the current scanning zone attribute;Or it is micro- Bubble cavitation zone is transitioned into imaging region;

If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, the control of scanning acoustic pressure is adjusted Parameter adaptation microvesicle cavitation zone processed automatically switches probe and arrives microvesicle after the completion of the control parameter adjustment of the scanning acoustic pressure Cavitation zone is scanned;

And restart timing, the microvesicle cavitation zone scanning duration is recorded, judges the microvesicle cavitation zone scanning Whether the duration is equal to the first preset threshold of system;

If so, stopping scanning microvesicle cavitation zone, the control parameter of adjustment scanning acoustic pressure adapts to imaging region, sweeps when described It looks into after the completion of the control parameter adjustment of acoustic pressure, automatically switches probe and be scanned to imaging region;

If it is not, continuing scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning duration;

If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone;

The control parameter for then adjusting scanning acoustic pressure adapts to imaging region, completes when the control parameter of the scanning acoustic pressure adjusts Afterwards, automatically switch probe to be scanned to imaging region;

Imaging region and microvesicle cavitation zone are reacquired according to the scanning result of the imaging region, and is adjusted described super The control parameter of the scanning acoustic pressure of sound microvesicle cavitation device.

As the further improvement of an embodiment of the present invention, the data processing module is also used to:

The system first is adjusted according to the transmitting pulse mode of the microvesicle cavitation zone and transmitting pulse recurrence frequency Preset threshold.

Compared with prior art, the image processing method and processing system of ultrasonic microbubble cavitation device of the invention, passes through Divide different regions and preset corresponding parameter, it can so that ultrasonic microbubble cavitation device is had two kinds of functions, realize letter It is single, save manufacture and use cost.

Detailed description of the invention

Fig. 1 is the flow diagram of the image processing method of ultrasonic microbubble cavitation device in an embodiment of the present invention;

Fig. 2 is the process signal of the image processing method of ultrasonic microbubble cavitation device in a preferred embodiment of the invention Figure;

Fig. 3 is the module diagram of the imaging processing system of ultrasonic microbubble cavitation device in an embodiment of the present invention;

Fig. 4 A, 4B, 4C are the structural schematic diagrams using the display interface of a specific example of the invention;

Fig. 5 A is the sound field three-dimensional distribution map of the imaging region obtained in a specific example of the invention;

Fig. 5 B is the sound field three-dimensional distribution map of the microvesicle cavitation zone obtained in a specific example of the invention.

Specific embodiment

Hereinafter, the present invention will be described in detail with reference to various embodiments shown in the accompanying drawings.But these embodiments are not The limitation present invention, structure that those skilled in the art are made according to these embodiments, method or change functionally It changes and is included within the scope of protection of the present invention.

It should be noted that present invention is mainly applied to ultrasonic device, correspondingly, the determinand can be test serum, It is not described in detail herein.

As shown in Figure 1, the image processing method of ultrasonic microbubble cavitation device includes: in an embodiment of the present invention

Obtain imaging region and microvesicle cavitation zone;

The size of the imaging region and the microvesicle cavitation zone, shape, position can be arbitrarily designated by user, can also Actively to be obtained by equipment;

In a specific example of the invention, the ultrasonic microbubble cavitation device is provided simultaneously with two kinds of functions, and one kind is biography The ultrasonic scan function of system, one kind are emerging technology, ultrasonic microbubble cavitation treatment function.

Under original state, starting ultrasonic microbubble cavitation device, the region identified automatically to needs is scanned, and according to It is abnormal that scanning result judges that the scanning result of current scanning zone whether there is, if so, it is planned to microvesicle cavitation zone, if It is no, it is planned to imaging region.

The ultrasonic microbubble cavitation technique is a kind of emerging technology, when ultrasonic wave passes through liquid, such as: blood, liquid The variation of the acoustic pressure meeting generating period of body everywhere.Correspondingly, the microvesicle core in liquid also can be with supersonic frequency generating period Oscillation;Under in a low voice by force, the radial oscillation of bubble is controlled by acoustic pressure, and microbubble vibrates repeatedly along equilibrium radius or so, Radiation pressure and microbeam stream will be generated around the microbubble of each oscillation;Microbeam stream can generate very high near bubble surface Shear stress power, make bubble deformation even rupture, cause neighbouring cell or large biological molecule to be affected, generate certain Biological effect;This microvesicle does periodic oscillating movement as equilibrium radius using its radius with acoustic pressure and is known as stable cavitation;When It acts on the sound intensity to increase, when making the oscillation amplitude of bubble can be comparable with its balance dimension, the vibration of bubble be i.e. then by around it The inertia of medium is controlled;Cavitation nucleus expands rapidly in the ultrasonic field negative pressure phase half period, and sharply receives in the positive pressure phase half period It is reduced to implosion, this cavitation is referred to as transient cavitation or inertial cavitation.Bubble oscillation is very fierce when transient cavitation, and initial bubble is first It is to expand explosively, withers then and rapidly;It withers the stage finally, localized hyperthermia, high-pressure phenomena can be generated;Inside bubble Pressure and temperature can achieve several hundred thousands of a atmospheric pressure and it is thousands of open, additionally with strong impact wave, high-speed micro-jet, The generation of free radical;The formation of these extreme physical conditions and chemical group is to the structure of normal cell and the bioactivity of enzyme There is great destruction, but tumour cell can be killed effectively simultaneously;Compared with stable cavitation, transient cavitation in addition to Microbubble occurs outside violent collapse, another difference is that the generation of transient cavitation must have certain threshold value, that is, works as When the acoustic pressure of ultrasound reaches certain value, it can just cause transient cavitation;Studies have shown that under transient cavitation, cell and tissue Risk by biological damage is higher;High-intensitive pressure wave can make cellular damage, rupture, DNA fracture and blood Haemolysis, tissue damage, bleeding etc..

Further, the method also includes: respectively to the control of the scanning acoustic pressure of imaging region and microvesicle cavitation zone Parameter is configured;

In a preferred embodiment of the invention, according to the size and location of the imaging region and the microvesicle cavitation zone Preset the scanning acoustic pressure of the ultrasonic microbubble cavitation device;The scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation Scanning acoustic pressure;Wherein, the imaging scanning acoustic pressure is lower than the microvesicle cavitation scanning acoustic pressure.

In an embodiment of the present invention, the control parameter of the scanning acoustic pressure includes: tranmitting frequency, emitting voltage, transmitting Pulse length emits pulse recurrence frequency, emits pulse mode and line density.

The tranmitting frequency, full name in English Frequency is adjustable to adjust exomonental centre frequency 1.6 are generally in the range of to 6.3MHZ;

The emitting voltage, full name in English is Transmit Voltage, by adjusting emitting voltage, to control transmitting Acoustical power and mechanical index, under the international standard of diagnostic ultrasound, the transmitting sound power is with IsptaIt indicates, Ispta<720 mW/ Cm2, mechanical index MI < 1.9;

Emit pulse length, also referred to as pulse width, full name in English is Pulse Length, to adjust transmitting arteries and veins The periodicity of punching, adjustable extent were usually 1 ~ 100 period;

Emit pulse recurrence frequency, english abbreviation PRF: in the case where transmitting pulse length determines, emitting pulse Repetition rate is the time interval adjusted between the pulse of same position twice emitting;

Emit pulse mode comprising two kinds, i.e., arteries and veins is emitted using single emission pulse or repeatedly to same scan line Punching;

Line density: during scanning, the ultrasonic scanning line density of transmitting, the scanning density can be specific as needed It adjusts, is not described in detail herein.

In the embodiment of the invention, the default result of the control parameter of the imaging scanning acoustic pressure of the imaging region It is as follows:

The section of the tranmitting frequency are as follows: 1.7-5.0MHz;

The section of the emitting voltage are as follows: 5.0-12.0V;

The section of the transmitting pulse length are as follows: 1-3 period;

The section of the transmitting pulse recurrence frequency are as follows: 10-30Hz;

The transmitting pulse mode: impulse ejection at least twice;

The distribution density of the line density of the imaging region is less than the line density of the microvesicle cavitation zone.

The default result of the control parameter of the microvesicle cavitation scanning acoustic pressure of the microvesicle cavitation zone is as follows:

The section of the tranmitting frequency are as follows: 1.0-6.3MHz;

The section of the emitting voltage are as follows: 10.0-20.0V;

The section of the transmitting pulse length are as follows: 1-50 period;

The section of the transmitting pulse recurrence frequency are as follows: 10-100Hz;

The transmitting pulse mode: single or multiple impulse ejections;

The line density of the microvesicle cavitation zone is greater than the line density of the imaging region.

In an embodiment of the present invention, the method also includes:

In predetermined interval, by the control parameter timesharing independent scan imaging region of respective scanning acoustic pressure or micro- Steep cavitation zone.

As shown in Fig. 2, the method specifically includes in a preferred embodiment of the invention:

Judge whether the attribute of current scanning zone changes, and is adjusted in real time according to current scanning zone attribute The scanning acoustic pressure and scanning mode of the ultrasonic microbubble cavitation device;In this way, can be more accurate meet the needs of users.

It includes: that imaging region is transitioned into microvesicle cavitation zone that transformation, which occurs, for the current scanning zone attribute;Or it is micro- Bubble cavitation zone is transitioned into imaging region;

If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, the control of scanning acoustic pressure is adjusted Parameter adaptation microvesicle cavitation zone processed automatically switches probe and arrives microvesicle after the completion of the control parameter adjustment of the scanning acoustic pressure Cavitation zone is scanned;

And restart timing, the microvesicle cavitation zone scanning duration is recorded, judges the microvesicle cavitation zone scanning Whether the duration is equal to the first preset threshold of system;

If so, stopping scanning microvesicle cavitation zone, the control parameter of adjustment scanning acoustic pressure adapts to imaging region, sweeps when described It looks into after the completion of the control parameter adjustment of acoustic pressure, automatically switches probe and be scanned to imaging region;

If it is not, continuing scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning duration;

First preset threshold is a fixed numbers, can according to need and voluntarily adjusts, can root in present embodiment First preset threshold of system is adjusted according to the transmitting pulse mode and transmitting pulse recurrence frequency of the microvesicle cavitation zone;

First preset threshold=transmitting pulse number/pulse recurrence frequency.

If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone;

The control parameter for then adjusting scanning acoustic pressure adapts to imaging region, completes when the control parameter of the scanning acoustic pressure adjusts Afterwards, automatically switch probe to be scanned to imaging region;

Imaging region and microvesicle cavitation zone are reacquired according to the scanning result of the imaging region, and is adjusted described super The control parameter of the scanning acoustic pressure of sound microvesicle cavitation device.In present embodiment, the method also includes: scanning imaging region is opened Begin, records the duration of scanning imaging region, judge whether the scanning duration of the scanning imaging region is equal to system Second preset threshold;If so, stopping scanning imaging region, the control parameter of adjustment scanning acoustic pressure adapts to microvesicle cavitation zone, and It is scanned.

Second preset threshold is similarly a fixed numbers, can according to need and voluntarily adjusts, and does not do herein in detail It repeats.

During the ultrasonic microbubble cavitation device scanning scanning, after scanning for the first time, the area identification of delimitation, actively Judge the area attribute of current scanning zone, and adjusts the scanning sound of the ultrasonic microbubble cavitation device according to the area attribute Pressure reduces the breakage of microvesicle to the greatest extent so that the contrast agent microbubble of imaging region is in pressure condition in a low voice to increase nonlinear echoes Intensity and microvesicle itself duration;And the contrast agent microbubble of microvesicle cavitation zone is in more loud pressure condition, by micro- The cavitation biological effect that the implosion of bubble generates, achievees the purpose that treatment;That is: the ultrasonic microbubble cavitation device is made to be provided simultaneously with inspection Look into the function with diagnosis and treatment.

In another embodiment of the present invention, during the method may also include that a scanning, real-time judge is current to be swept The attribute for looking into region is imaging region or microvesicle cavitation zone, and adjusts described surpass in real time according to current scanning zone attribute The scanning acoustic pressure of sound microvesicle cavitation device;

During the ultrasonic microbubble cavitation device scanning scanning, after scanning for the first time, the area identification of delimitation, actively Judge the area attribute of current scanning zone, and adjusts the scanning sound of the ultrasonic microbubble cavitation device according to the area attribute Pressure reduces the breakage of microvesicle to the greatest extent so that the contrast agent microbubble of imaging region is in pressure condition in a low voice to increase nonlinear echoes Intensity and microvesicle itself duration;And the contrast agent microbubble of microvesicle cavitation zone is in more loud pressure condition, by micro- The cavitation biological effect that the implosion of bubble generates, achievees the purpose that treatment;That is: the ultrasonic microbubble cavitation device is made to be provided simultaneously with inspection Look into the function with diagnosis and treatment.

Further, after the completion of a scanning, imaging region and microvesicle cavitation zone are reacquired, and adjust the ultrasound The scanning acoustic pressure of microvesicle cavitation device.In this way, can be more accurate meet the needs of users.

In both the above embodiment, in one of scheme, ultrasonic microbubble cavitation device is independent complete within the same time The scanning of pairs of imaging region or microvesicle cavitation zone, wherein within the same period, being completed at the same time into another scheme As the scanning in region and microvesicle cavitation zone.Both the above mode can make ultrasonic microbubble cavitation device have two kinds of functions, It realizes simply, saves manufacture and use cost, be not described in detail herein.

As shown in connection with fig. 3, the imaging processing system of the ultrasonic microbubble cavitation device provided in an embodiment of the present invention, institute The system of stating includes: data acquisition module 100, data processing module 200;

Data acquisition module 100 is for obtaining imaging region and microvesicle cavitation zone;

The size of the imaging region and the microvesicle cavitation zone, shape, position can be arbitrarily designated by user, can also Actively to be obtained by equipment;

In a specific example of the invention, the ultrasonic microbubble cavitation device is provided simultaneously with two kinds of functions, and one kind is biography The ultrasonic scan function of system, one kind are emerging technology, ultrasonic microbubble cavitation treatment function.

Under original state, starting ultrasonic microbubble cavitation device, the region identified automatically to needs is scanned, and according to Scanning result judges the scanning result of current scanning zone with the presence or absence of exception, if data acquisition module 100, is planned to Microvesicle cavitation zone, if it is not, being planned to imaging region.

The ultrasonic microbubble cavitation technique is a kind of emerging technology, when ultrasonic wave passes through liquid, such as: blood, liquid The variation of the acoustic pressure meeting generating period of body everywhere.Correspondingly, the microvesicle core in liquid also can be with supersonic frequency generating period Oscillation;Under in a low voice by force, the radial oscillation of bubble is controlled by acoustic pressure, and microbubble vibrates repeatedly along equilibrium radius or so, Radiation pressure and microbeam stream will be generated around the microbubble of each oscillation;Microbeam stream can generate very high near bubble surface Shear stress power, make bubble deformation even rupture, cause neighbouring cell or large biological molecule to be affected, generate certain Biological effect;This microvesicle does periodic oscillating movement as equilibrium radius using its radius with acoustic pressure and is known as stable cavitation;When It acts on the sound intensity to increase, when making the oscillation amplitude of bubble can be comparable with its balance dimension, the vibration of bubble be i.e. then by around it The inertia of medium is controlled;Cavitation nucleus expands rapidly in the ultrasonic field negative pressure phase half period, and sharply receives in the positive pressure phase half period It is reduced to implosion, this cavitation is referred to as transient cavitation or inertial cavitation.Bubble oscillation is very fierce when transient cavitation, and initial bubble is first It is to expand explosively, withers then and rapidly;It withers the stage finally, localized hyperthermia, high-pressure phenomena can be generated;Inside bubble Pressure and temperature can achieve several hundred thousands of a atmospheric pressure and it is thousands of open, additionally with strong impact wave, high-speed micro-jet, The generation of free radical;The formation of these extreme physical conditions and chemical group is to the structure of normal cell and the bioactivity of enzyme There is great destruction, but tumour cell can be killed effectively simultaneously;Compared with stable cavitation, transient cavitation in addition to Microbubble occurs outside violent collapse, another difference is that the generation of transient cavitation must have certain threshold value, that is, works as When the acoustic pressure of ultrasound reaches certain value, it can just cause transient cavitation;Studies have shown that under transient cavitation, cell and tissue Risk by biological damage is higher;High-intensitive pressure wave can make cellular damage, rupture, DNA fracture and blood Haemolysis, tissue damage, bleeding etc..

Data processing module 200 is used for: respectively to the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone It is configured;

In an of the invention preferred embodiment, data processing module 200 is specifically used for: according to the imaging region and described The size and location of microvesicle cavitation zone preset the scanning acoustic pressure of the ultrasonic microbubble cavitation device;The scanning acoustic pressure includes: Scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure is imaged;Wherein, the imaging scanning acoustic pressure is lower than the microvesicle cavitation scanning sound Pressure.

In an embodiment of the present invention, the control parameter of the scanning acoustic pressure includes: tranmitting frequency, emitting voltage, transmitting Pulse length emits pulse recurrence frequency, emits pulse mode and line density.

The tranmitting frequency, full name in English Frequency is adjustable to adjust exomonental centre frequency 1.6 are generally in the range of to 6.3MHZ;

The emitting voltage, full name in English is Transmit Voltage, by adjusting emitting voltage, to control transmitting Acoustical power and mechanical index, under the international standard of diagnostic ultrasound, the transmitting sound power is with IsptaIt indicates, Ispta<720 mW/ Cm2, mechanical index MI < 1.9;

Emit pulse length, also referred to as pulse width, full name in English is Pulse Length, to adjust transmitting arteries and veins The periodicity of punching, adjustable extent were usually 1 ~ 100 period;

Emit pulse recurrence frequency, english abbreviation PRF: in the case where transmitting pulse length determines, emitting pulse Repetition rate is the time interval adjusted between the pulse of same position twice emitting;

Emit pulse mode comprising two kinds, i.e., arteries and veins is emitted using single emission pulse or repeatedly to same scan line Punching;

Line density: during scanning, the ultrasonic scanning line density of transmitting, the scanning density can be specific as needed It adjusts, is not described in detail herein.

In the embodiment of the invention, the default result of the control parameter of the imaging scanning acoustic pressure of the imaging region It is as follows:

The section of the tranmitting frequency are as follows: 1.7-5.0MHz;

The section of the emitting voltage are as follows: 5.0-12.0V;

The section of the transmitting pulse length are as follows: 1-3 period;

The section of the transmitting pulse recurrence frequency are as follows: 10-30Hz;

The transmitting pulse mode: impulse ejection at least twice;

The distribution density of the line density of the imaging region is less than the line density of the microvesicle cavitation zone.

The default result of the control parameter of the microvesicle cavitation scanning acoustic pressure of the microvesicle cavitation zone is as follows:

The section of the tranmitting frequency are as follows: 1.0-6.3MHz;

The section of the emitting voltage are as follows: 10.0-20.0V;

The section of the transmitting pulse length are as follows: 1-50 period;

The section of the transmitting pulse recurrence frequency are as follows: 10-100Hz;

The transmitting pulse mode: single or multiple impulse ejections;

The line density of the microvesicle cavitation zone is greater than the line density of the imaging region.

Further, in an embodiment of the present invention, data processing module 200 is also used to: in predetermined interval, being led to Cross the control parameter timesharing independent scan imaging region or microvesicle cavitation zone of respective scanning acoustic pressure.

In a preferred embodiment of the invention, data processing module 200 is specifically used for:

Judge whether the attribute of current scanning zone changes, and is adjusted in real time according to current scanning zone attribute The scanning acoustic pressure and scanning mode of the ultrasonic microbubble cavitation device;In this way, can be more accurate meet the needs of users.

It includes: that imaging region is transitioned into microvesicle cavitation zone that transformation, which occurs, for the current scanning zone attribute;Or it is micro- Bubble cavitation zone is transitioned into imaging region;

If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, data processing module 200 is used Microvesicle cavitation zone is adapted in the control parameter of adjustment scanning acoustic pressure, after the completion of the control parameter adjustment of the scanning acoustic pressure, Automatically switch probe to be scanned to microvesicle cavitation zone;And restart timing, when record microvesicle cavitation zone scanning continues Between, judge whether the microvesicle cavitation zone scanning duration is equal to the first preset threshold of system;

If so, stopping scanning microvesicle cavitation zone, the control parameter of adjustment scanning acoustic pressure adapts to imaging region, sweeps when described It looks into after the completion of the control parameter adjustment of acoustic pressure, automatically switches probe and be scanned to imaging region;

If it is not, continuing scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning duration;

First preset threshold is a fixed numbers, can according to need and voluntarily adjusts, can root in present embodiment First preset threshold of system is adjusted according to the transmitting pulse mode and transmitting pulse recurrence frequency of the microvesicle cavitation zone;

First preset threshold=transmitting pulse number/pulse recurrence frequency.

If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone;

Data processing module 200 is used for: the control parameter of adjustment scanning acoustic pressure adapts to imaging region, when the scanning acoustic pressure Control parameter adjustment after the completion of, automatically switch probe be scanned to imaging region;

Imaging region and microvesicle cavitation zone are reacquired according to the scanning result of the imaging region, and is adjusted described super The control parameter of the scanning acoustic pressure of sound microvesicle cavitation device.

In present embodiment, data processing module 200 is also used to after scanning imaging region starts, and records scanning imaging area The duration in domain, judge whether the scanning duration of the scanning imaging region is equal to the second preset threshold of system;If so, Stop scanning imaging region, the control parameter of adjustment scanning acoustic pressure adapts to microvesicle cavitation zone, and is scanned.

Second preset threshold is similarly a fixed numbers, can according to need and voluntarily adjusts, and does not do herein in detail It repeats.

During the ultrasonic microbubble cavitation device scanning scanning, after data processing module 200 is according to scanning for the first time, delimit Area identification, actively judge the area attribute of current scanning zone, and the ultrasonic microbubble is adjusted according to the area attribute The scanning acoustic pressure of cavitation device reduces the breakage of microvesicle to the greatest extent so that the contrast agent microbubble of imaging region is in pressure condition in a low voice To increase the intensity of nonlinear echoes and the duration of microvesicle itself;And the contrast agent microbubble of microvesicle cavitation zone is in higher Acoustic pressure state, the cavitation biological effect generated by the implosion of microvesicle, achievees the purpose that treatment;That is: make the ultrasonic microbubble empty Change the function that equipment is provided simultaneously with inspection and diagnosis and treatment.

In another embodiment of the present invention, data processing module 200 is also used to: during a scanning, real-time judge is worked as The attribute of preceding scanning zone is imaging region or microvesicle cavitation zone, and is adjusted in real time according to current scanning zone attribute The scanning acoustic pressure of the ultrasonic microbubble cavitation device;

During the ultrasonic microbubble cavitation device scanning scanning, after data processing module 200 is according to scanning for the first time, delimit Area identification, actively judge the area attribute of current scanning zone, and the ultrasonic microbubble is adjusted according to the area attribute The scanning acoustic pressure of cavitation device reduces the breakage of microvesicle to the greatest extent so that the contrast agent microbubble of imaging region is in pressure condition in a low voice To increase the intensity of nonlinear echoes and the duration of microvesicle itself;And the contrast agent microbubble of microvesicle cavitation zone is in higher Acoustic pressure state, the cavitation biological effect generated by the implosion of microvesicle, achievees the purpose that treatment;That is: make the ultrasonic microbubble empty Change the function that equipment is provided simultaneously with inspection and diagnosis and treatment.

Further, after the completion of a scanning, data processing module 200 reacquires imaging region and microvesicle cavitation area Domain, and adjust the scanning acoustic pressure of the ultrasonic microbubble cavitation device.In this way, can be more accurate meet the needs of users.

In both the above embodiment, in one of scheme, ultrasonic microbubble cavitation device is independent complete within the same time The scanning of pairs of imaging region or microvesicle cavitation zone, wherein within the same period, being completed at the same time into another scheme As the scanning in region and microvesicle cavitation zone.Both the above mode can make ultrasonic microbubble cavitation device have two kinds of functions, It realizes simply, saves manufacture and use cost, be not described in detail herein.

In conjunction with shown in Fig. 4 A to Fig. 4 C, the ultrasonic microbubble cavitation device of the one application above method of the present invention and system;

The ultrasonic microbubble cavitation device in use, in order to facilitate user's operation, establishes main operation interface and phase The auxiliary operation interface answered, in use process, user can be touched or be clicked corresponding in the operation interface by peripheral apparatus Button, later, ultrasonic microbubble cavitation device can execute the instruction of the corresponding button representative automatically, use the above method automatically on backstage And system realizes the function of ultrasonic microbubble cavitation device.

As shown in Figure 4 A, it is provided with several on the display interface for the main operation interface of a ultrasonic microbubble cavitation device The button of different function can be realized automatically, wherein after entering icon " CBI ", imaging region can be cut automatically, correspondingly, institute Multiple auxiliary display interfaces can accordingly be occurred by stating imaging region, and one of auxiliary display interface is as shown in Figure 4 B;Into icon After " Vflash ", it can be cut into microvesicle cavitation zone automatically, shown correspondingly, multiple auxiliary can accordingly occur in the imaging region Show interface, one of auxiliary display interface is as shown in Figure 4 C.

It as shown in Figure 4 B, can be according to scanning as a result, automatically switching to microvesicle cavitation area after scanning is completed as regions Domain is scanned, and can also be entered microvesicle cavitation zone by user's selection and is scanned, and in this example, is arranged at the interface CBI " VFLASH " button, and " exiting " button voluntarily select next step process in this way, user can be as needed.

Such as Fig. 4 C, after entering the interface VFLASH, START button is set at the interface VFLASH, when operation START button Afterwards, " duration " shows the scanning time schedule of current record automatically, when " scanning time " progress bar is shown as full, table Show that the microvesicle cavitation zone scanning duration is equal to the first preset threshold of system, correspondingly, setting is gone back at the interface VFLASH Corresponding setting " exiting " button, " end " button and " CBI " button, according to user's needs, voluntarily select next stepping with this Journey is not described in detail herein.

In conjunction with shown in Fig. 5 A, 5B, the imaging region and micro- that is obtained in the embodiment of the invention using above system Steep the sound field three-dimensional distribution map of cavitation zone;

By diagram: all measurement results meet theory expectation;Sound field meets Gaussian Profile in Y direction;Arc battle array In the distribution of X-axis: being half period cosine distribution in microvesicle cavitation zone sampling window, be not complete distributed rectangular;Outside window with It is weaker apart from windowsill more far sound field, it is substantially in Gaussian Profile;Distribution of the linear array in X-axis: being square in microvesicle cavitation zone sampling window Shape distribution;It is in Gaussian Profile outside window with weaker apart from windowsill more far sound field.

It is apparent to those skilled in the art that for convenience and simplicity of description, the system of foregoing description It can be referred to mutually with the corresponding process in the specific work process and preceding method embodiment of module, details are not described herein.

In conclusion the image processing method and processing system of ultrasonic microbubble cavitation device of the invention, by dividing not Same region and preset corresponding parameter, it can so that ultrasonic microbubble cavitation device is had two kinds of functions, realize simple, section Save manufacture and use cost.

For convenience of description, it is divided into various modules when description apparatus above with function to describe respectively.Certainly, implementing this The function of each module can be realized in the same or multiple software and or hardware when application.

As seen through the above description of the embodiments, those skilled in the art can be understood that the application can It realizes by means of software and necessary general hardware platform.Based on this understanding, the technical solution essence of the application On in other words the part that contributes to existing technology can be embodied in the form of software products, which can protect In the presence of saving in medium, such as ROM/RAM, magnetic disk, CD, including some instructions are used so that computer equipment (can be with It is personal computer, Information Push Server or the network equipment etc.) execute each embodiment of the application or embodiment Certain parts described in method.

Device embodiments described above are only schematical, wherein the module as illustrated by the separation member It may or may not be physically separated, the component shown as module may or may not be physics mould Block, it can it is in one place, or may be distributed on multiple network modules.It can be selected according to the actual needs In some or all of the modules realize the purpose of present embodiment scheme.Those of ordinary skill in the art are not paying creation Property labour in the case where, it can understand and implement.

The application can describe in the general context of computer-executable instructions executed by a computer, such as program Module.Generally, program module includes routines performing specific tasks or implementing specific abstract data types, programs, objects, group Part, data structure etc..The application can also be practiced in a distributed computing environment, in these distributed computing environments, by Task is executed by the connected remote processing devices of communication network.In a distributed computing environment, program module can be with It is saved in medium positioned at the local and remote computer including saving equipment.

It should be appreciated that although this specification is described in terms of embodiments, but not each embodiment only includes one A independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should will say As a whole, the technical solution in each embodiment may also be suitably combined to form those skilled in the art can for bright book With the other embodiments of understanding.

The series of detailed descriptions listed above only for feasible embodiment of the invention specifically Protection scope bright, that they are not intended to limit the invention, it is all without departing from equivalent implementations made by technical spirit of the present invention Or change should all be included in the protection scope of the present invention.

Claims (8)

1. a kind of image processing method of ultrasonic microbubble cavitation device, which is characterized in that the described method comprises the following steps:
Obtain imaging region and microvesicle cavitation zone;
The control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone is configured respectively;
The control parameter of the scanning acoustic pressure includes: tranmitting frequency, and emitting voltage emits pulse length, and transmitting pulse repeats frequency Rate emits pulse mode and line density;
It is empty by the control parameter timesharing independent scan imaging region or microvesicle of respective scanning acoustic pressure in predetermined interval Change region;
Wherein, " in predetermined interval, pass through the control parameter independent scan imaging region or microvesicle of respective scanning acoustic pressure Cavitation zone " specifically includes:
Judge whether the attribute of current scanning zone changes,
It includes: that imaging region is transitioned into microvesicle cavitation zone that transformation, which occurs, for the current scanning zone attribute;Or microvesicle is empty Change region transfers to imaging region;
If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, the control ginseng of scanning acoustic pressure is adjusted Number adapts to microvesicle cavitation zone, after the completion of the control parameter adjustment of the scanning acoustic pressure, automatically switches probe and arrives microvesicle cavitation Region is scanned;
And restart timing, the microvesicle cavitation zone scanning duration is recorded, judges that the microvesicle cavitation zone scanning continues Whether the time is equal to the first preset threshold of system;
If so, stopping scanning microvesicle cavitation zone, the control parameter of adjustment scanning acoustic pressure adapts to imaging region, when the scanning sound After the completion of the control parameter adjustment of pressure, automatically switches probe and be scanned to imaging region;
If it is not, continuing scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning duration;
If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone;
The control parameter for then adjusting scanning acoustic pressure adapts to imaging region, after the completion of the control parameter adjustment of the scanning acoustic pressure, Automatically switch probe to be scanned to imaging region;
Imaging region and microvesicle cavitation zone are reacquired according to the scanning result of the imaging region, and it is micro- to adjust the ultrasound Steep the control parameter of the scanning acoustic pressure of cavitation device.
2. the image processing method of ultrasonic microbubble cavitation device according to claim 1, which is characterized in that " respectively at As the control parameter in region and the scanning acoustic pressure of microvesicle cavitation zone is configured " it specifically includes:
The ultrasonic microbubble cavitation device is preset according to the size and location of the imaging region and the microvesicle cavitation zone Scanning acoustic pressure;The scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure;
Wherein, the imaging scanning acoustic pressure is lower than the microvesicle cavitation scanning acoustic pressure.
3. the image processing method of ultrasonic microbubble cavitation device according to claim 2, which is characterized in that
The control parameter of the imaging scanning acoustic pressure of the imaging region specifically includes:
The section of the tranmitting frequency are as follows: 1.7-5.0MHz;
The section of the emitting voltage are as follows: 5.0-12.0V;
The section of the transmitting pulse length are as follows: 1-3 period;
The section of the transmitting pulse recurrence frequency are as follows: 10-30Hz;
The transmitting pulse mode: impulse ejection at least twice;
The distribution density of the line density of the imaging region is less than the line density of the microvesicle cavitation zone;
The control parameter of the microvesicle cavitation scanning acoustic pressure of the microvesicle cavitation zone specifically includes:
The section of the tranmitting frequency are as follows: 1.0-6.3MHz;
The section of the emitting voltage are as follows: 10.0-20.0V;
The section of the transmitting pulse length are as follows: 1-50 period;
The section of the transmitting pulse recurrence frequency are as follows: 10-100Hz;
The transmitting pulse mode: single or multiple impulse ejections;
The line density of the microvesicle cavitation zone is greater than the line density of the imaging region.
4. the image processing method of ultrasonic microbubble cavitation device according to claim 1, which is characterized in that the method is also Include:
It is default that the system first is adjusted according to the transmitting pulse mode of the microvesicle cavitation zone and transmitting pulse recurrence frequency Threshold value.
5. a kind of imaging processing system of ultrasonic microbubble cavitation device, which is characterized in that the system comprises:
Data acquisition module, for obtaining imaging region and microvesicle cavitation zone;
Data processing module, the control parameter for the scanning acoustic pressure respectively to imaging region and microvesicle cavitation zone are set It sets;The control parameter of the scanning acoustic pressure includes: tranmitting frequency, and emitting voltage emits pulse length, and transmitting pulse repeats frequency Rate emits pulse mode and line density;
It is empty by the control parameter timesharing independent scan imaging region or microvesicle of respective scanning acoustic pressure in predetermined interval Change region;
Wherein, the data processing module is specifically used for:
Judge whether the attribute of current scanning zone changes,
It includes: that imaging region is transitioned into microvesicle cavitation zone that transformation, which occurs, for the current scanning zone attribute;Or microvesicle is empty Change region transfers to imaging region;
If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, the control ginseng of scanning acoustic pressure is adjusted Number adapts to microvesicle cavitation zone, after the completion of the control parameter adjustment of the scanning acoustic pressure, automatically switches probe and arrives microvesicle cavitation Region is scanned;
And restart timing, the microvesicle cavitation zone scanning duration is recorded, judges that the microvesicle cavitation zone scanning continues Whether the time is equal to the first preset threshold of system;
If so, stopping scanning microvesicle cavitation zone, the control parameter of adjustment scanning acoustic pressure adapts to imaging region, when the scanning sound After the completion of the control parameter adjustment of pressure, automatically switches probe and be scanned to imaging region;
If it is not, continuing scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning duration;
If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone;
The control parameter for then adjusting scanning acoustic pressure adapts to imaging region, after the completion of the control parameter adjustment of the scanning acoustic pressure, Automatically switch probe to be scanned to imaging region;
Imaging region and microvesicle cavitation zone are reacquired according to the scanning result of the imaging region, and it is micro- to adjust the ultrasound Steep the control parameter of the scanning acoustic pressure of cavitation device.
6. the imaging processing system of ultrasonic microbubble cavitation device according to claim 5, which is characterized in that
The data processing module is specifically used for: the size and location according to the imaging region and the microvesicle cavitation zone are pre- If the scanning acoustic pressure of the ultrasonic microbubble cavitation device;The scanning acoustic pressure includes: that imaging scanning acoustic pressure and microvesicle cavitation are swept Look into acoustic pressure.
7. the imaging processing system of ultrasonic microbubble cavitation device according to claim 6, which is characterized in that
The control parameter of the imaging scanning acoustic pressure of the imaging region specifically includes:
The section of the tranmitting frequency are as follows: 1.7-5.0MHz;
The section of the emitting voltage are as follows: 5.0-12.0V;
The section of the transmitting pulse length are as follows: 1-3 period;
The section of the transmitting pulse recurrence frequency are as follows: 10-30Hz;
The transmitting pulse mode: impulse ejection at least twice;
The distribution density of the line density of the imaging region is less than the line density of the microvesicle cavitation zone;
The control parameter of the microvesicle cavitation scanning acoustic pressure of the microvesicle cavitation zone specifically includes:
The section of the tranmitting frequency are as follows: 1.0-6.3MHz;
The section of the emitting voltage are as follows: 10.0-20.0V;
The section of the transmitting pulse length are as follows: 1-50 period;
The section of the transmitting pulse recurrence frequency are as follows: 10-100Hz;
The transmitting pulse mode: single or multiple impulse ejections;
The line density of the microvesicle cavitation zone is greater than the line density of the imaging region.
8. the imaging processing system of ultrasonic microbubble cavitation device according to claim 5, which is characterized in that at the data Reason module is also used to:
It is default that the system first is adjusted according to the transmitting pulse mode of the microvesicle cavitation zone and transmitting pulse recurrence frequency Threshold value.
CN201610591033.7A 2016-07-26 2016-07-26 The image processing method and processing system of ultrasonic microbubble cavitation device CN105943087B (en)

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