CN105943087A - Imaging processing method and processing system of ultrasound micro bubble cavitation equipment - Google Patents
Imaging processing method and processing system of ultrasound micro bubble cavitation equipment Download PDFInfo
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- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
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- A61N2007/0039—Ultrasound therapy using microbubbles
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Abstract
The invention provides an imaging processing method and a processing system of ultrasound micro bubble cavitation equipment. The processing method comprises the steps that an imaging area and a micro bubble cavitation area are obtained; control parameters of canning sound pressure of the imaging area and the micro bubble cavitation area are set respectively; the control parameters of canning sound pressure comprise transmitting frequency, transmitting voltage, transmitting pulse length, transmitting pulse repetition frequency, transmitting pulse manners and linear density; in the scheduled time interval, the imaging area or the micro bubble cavitation area is scanned independently in a time sharing manner through the control parameters of respect canning sound pressure. According to the imaging processing method and the processing system of the ultrasound micro bubble cavitation equipment, the ultrasound micro bubble cavitation equipment can have two kinds of functions by dividing different areas and presetting corresponding parameters, the implementation is easy, and the manufacturing cost and the use cost are saved.
Description
Technical field
The invention belongs to medical ultrasound technical field, relate generally to image processing method and the processing system of a kind of ultrasonic microbubble cavitation device.
Background technology
Ultra sonic imaging is because of many advantages such as it is non-invasive, real-time, easy to operate, low prices so that it is become one of the means of the auxiliary diagnosis being most widely used clinically.
Ultrasonic microbubble cavitation technique is a kind of emerging technology, is currently in the high speed development stage, uses the ultrasonic microbubble equipment of this technology manufacture for treating the diseases such as tumor.
In prior art, owing to ultra sonic imaging is runed counter to ultrasonic microbubble cavitation treatment demand, that is: under ultra sonic imaging state, the breakage of needs minimizing microvesicle as far as possible is to increase intensity and the persistent period of microvesicle itself of nonlinear echoes, and under the conditions of ultrasonic microbubble cavitation treatment, needs contrast agent microbubble transient cavitation or inertial cavitation, the cavitation biological effect produced by the implosion of microvesicle, reach the purpose for the treatment of, so, it is impossible to use same equipment diagnose simultaneously and treat.
Summary of the invention
It is an object of the invention to provide image processing method and the processing system of a kind of ultrasonic microbubble cavitation device.
In order to realize one of foregoing invention purpose, the image processing method of the ultrasonic microbubble cavitation device of an embodiment of the present invention, said method comprising the steps of: obtain imaging region and microvesicle cavitation zone；
Respectively the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone is configured；
The control parameter of described scanning acoustic pressure includes: tranmitting frequency, emitting voltage, launches pulse length, launches pulse recurrence frequency, launches pulse mode, and line density；
In predetermined interval, by control parameter timesharing independent scan imaging region or the microvesicle cavitation zone of respective scanning acoustic pressure.
As the further improvement of an embodiment of the present invention, " being configured the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone respectively " specifically includes:
Size and location according to described imaging region and described microvesicle cavitation zone preset the scanning acoustic pressure of described ultrasonic microbubble cavitation device；Described scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure；
Wherein, described imaging scanning acoustic pressure is less than described microvesicle cavitation scanning acoustic pressure.
As the further improvement of an embodiment of the present invention, the control parameter of the imaging scanning acoustic pressure of described imaging region specifically includes:
The interval of described tranmitting frequency is: 1.7-5.0MHz；
The interval of described emitting voltage is: 5.0-12.0V；
The interval of described transmitting pulse length is: the 1-3 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-30Hz；
Described transmitting pulse mode: impulse ejection at least twice；
The distribution density of the line density of described imaging region is less than the line density of described microvesicle cavitation zone；
The control parameter of the microvesicle cavitation scanning acoustic pressure of described microvesicle cavitation zone specifically includes:
The interval of described tranmitting frequency is: 1.0-6.3MHz；
The interval of described emitting voltage is: 10.0-20.0V；
The interval of described transmitting pulse length is: the 1-50 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-100Hz；
Described transmitting pulse mode: single or multiple impulse ejection；
The line density of described microvesicle cavitation zone is more than the line density of described imaging region.
As the further improvement of an embodiment of the present invention, " in predetermined interval, by control parameter independent scan imaging region or the microvesicle cavitation zone of respective scanning acoustic pressure " specifically includes:
Judge whether the attribute of current scanning zone changes,
Described current scanning zone attribute generation transformation includes: imaging region is transitioned into microvesicle cavitation zone；Or microvesicle cavitation zone is transitioned into imaging region；
If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, then adjust the control parameter adaptation microvesicle cavitation zone of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to microvesicle cavitation zone；
And restart timing, record the microvesicle cavitation zone scanning persistent period, it is judged that whether the described microvesicle cavitation zone scanning persistent period is equal to system the first predetermined threshold value；
If so, stopping scanning microvesicle cavitation zone, adjust the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
If it is not, continue scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning persistent period；
If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone；
Then adjusting the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
Scanning result according to described imaging region reacquires imaging region and microvesicle cavitation zone, and adjusts the control parameter of the scanning acoustic pressure of described ultrasonic microbubble cavitation device.
As the further improvement of an embodiment of the present invention, described method also includes:
Transmitting pulse mode and transmitting pulse recurrence frequency according to described microvesicle cavitation zone adjust described system the first predetermined threshold value.
In order to realize one of foregoing invention purpose, an embodiment of the present invention provides the imaging processing system of a kind of ultrasonic microbubble cavitation device, and described system includes: data acquisition module, is used for obtaining imaging region and microvesicle cavitation zone；
Data processing module, for being configured the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone respectively；The control parameter of described scanning acoustic pressure includes: tranmitting frequency, emitting voltage, launches pulse length, launches pulse recurrence frequency, launches pulse mode, and line density；
In predetermined interval, by control parameter timesharing independent scan imaging region or the microvesicle cavitation zone of respective scanning acoustic pressure.
As the further improvement of an embodiment of the present invention, described data processing module specifically for: preset the scanning acoustic pressure of described ultrasonic microbubble cavitation device according to the size and location of described imaging region and described microvesicle cavitation zone；Described scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure.
As the further improvement of an embodiment of the present invention, the control parameter of the imaging scanning acoustic pressure of described imaging region specifically includes:
The interval of described tranmitting frequency is: 1.7-5.0MHz；
The interval of described emitting voltage is: 5.0-12.0V；
The interval of described transmitting pulse length is: the 1-3 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-30Hz；
Described transmitting pulse mode: impulse ejection at least twice；
The distribution density of the line density of described imaging region is less than the line density of described microvesicle cavitation zone；
The control parameter of the microvesicle cavitation scanning acoustic pressure of described microvesicle cavitation zone specifically includes:
The interval of described tranmitting frequency is: 1.0-6.3MHz；
The interval of described emitting voltage is: 10.0-20.0V；
The interval of described transmitting pulse length is: the 1-50 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-100Hz；
Described transmitting pulse mode: single or multiple impulse ejection；
The line density of described microvesicle cavitation zone is more than the line density of described imaging region.
As the further improvement of an embodiment of the present invention, described data processing module specifically for:
Judge whether the attribute of current scanning zone changes,
Described current scanning zone attribute generation transformation includes: imaging region is transitioned into microvesicle cavitation zone；Or microvesicle cavitation zone is transitioned into imaging region；
If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, then adjust the control parameter adaptation microvesicle cavitation zone of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to microvesicle cavitation zone；
And restart timing, record the microvesicle cavitation zone scanning persistent period, it is judged that whether the described microvesicle cavitation zone scanning persistent period is equal to system the first predetermined threshold value；
If so, stopping scanning microvesicle cavitation zone, adjust the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
If it is not, continue scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning persistent period；
If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone；
Then adjusting the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
Scanning result according to described imaging region reacquires imaging region and microvesicle cavitation zone, and adjusts the control parameter of the scanning acoustic pressure of described ultrasonic microbubble cavitation device.
As the further improvement of an embodiment of the present invention, described data processing module is additionally operable to:
Transmitting pulse mode and transmitting pulse recurrence frequency according to described microvesicle cavitation zone adjust described system the first predetermined threshold value.
Compared with prior art, the image processing method of the ultrasonic microbubble cavitation device of the present invention and processing system, by dividing different regions, and preset corresponding parameter, can be so that ultrasonic microbubble cavitation device possess two kinds of functions, it is achieved simple, save and manufacture and use cost.
Accompanying drawing explanation
Fig. 1 is the schematic flow sheet of the image processing method of ultrasonic microbubble cavitation device in an embodiment of the present invention；
Fig. 2 is the schematic flow sheet of the image processing method of ultrasonic microbubble cavitation device in the present invention one preferred implementation；
Fig. 3 is the module diagram of the imaging processing system of ultrasonic microbubble cavitation device in an embodiment of the present invention；
Fig. 4 A, 4B, 4C are the structural representations of the display interface of the application concrete example of the present invention one；
Fig. 5 A is the sound field three-dimensional distribution map of the imaging region obtained in the concrete example of the present invention one；
Fig. 5 B is the sound field three-dimensional distribution map of the microvesicle cavitation zone obtained in the concrete example of the present invention one.
Detailed description of the invention
Describe the present invention below with reference to each embodiment shown in the drawings.But these embodiments are not limiting as the present invention, structure, method or conversion functionally that those of ordinary skill in the art is made according to these embodiments are all contained in protection scope of the present invention.
It should be noted that present invention is mainly applied to ultrasonic device, accordingly, described determinand can be tissue to be measured, is not described in detail at this.
As it is shown in figure 1, the image processing method of ultrasonic microbubble cavitation device includes in an embodiment of the present invention:
Obtain imaging region and microvesicle cavitation zone；
Described imaging region and the size of described microvesicle cavitation zone, shape, position can be arbitrarily designated by user, it is also possible to by equipment active obtaining；
In a concrete example of the present invention, described ultrasonic microbubble cavitation device is provided simultaneously with two kinds of functions, and a kind of for traditional ultrasonic scan function, one is emerging technology, ultrasonic microbubble cavitation treatment function.
Under original state, starting ultrasonic microbubble cavitation device, it is automatically to needing the region identified to be scanned, and judge whether the scanning result of current scanning zone exists exception according to scanning result, if so, it is planned to microvesicle cavitation zone, if it is not, be planned to imaging region.
Described ultrasonic microbubble cavitation technique is a kind of emerging technology, when ultrasound wave is by liquid, such as: blood, and the change of liquid acoustic pressure meeting generating period everywhere.Correspondingly, the microvesicle core in liquid also can be with the vibration of supersonic frequency generating period；Under the low sound intensity, the radial oscillation of bubble is vibrated repeatedly by acoustic pressure control, microbubble along about equilibrium radius, will produce radiation pressure and microbeam stream around each microbubble vibrated；Microbeam stream can produce the highest shear stress power near bubble surface, makes bubble deformation even rupture, and causes neighbouring cell or biomacromolecule to be affected, produces certain biological effect；This microvesicle does periodic oscillating movement with its radius for equilibrium radius with acoustic pressure and is referred to as stable cavitation；When effect the sound intensity increase, make bubble oscillation amplitude can comparable with its balance dimension time, the vibration of bubble i.e. then controlled by the inertia of medium about；Cavitation nucleus expanded rapidly in the ultrasonic field negative pressure phase half period, and was drastically contracted to implosion in the malleation phase half period, and this cavitation is referred to as transient cavitation or inertial cavitation.During transient cavitation, bubble oscillation is very fierce, and initial bubble explosion type before this ground expands, and withers the most rapidly；Wither the stage finally, localized hyperthermia, high-pressure phenomena can be produced；Pressure and temperature within Pao can reach hundreds of thousands of atmospheric pressure and thousands of open, additionally with powerful shock wave, high-speed micro-jet, the generation of free radical；The biological activity to Normocellular structure and enzyme that formed of these extreme physical conditions and chemical group has great destruction, but can effectively kill tumor cell simultaneously；Compared with stable cavitation, transient cavitation, in addition to microbubble occurs violent collapse, another difference is that the generation of transient cavitation must have certain threshold value, i.e. when ultrasonic acoustic pressure reaches certain value, just can cause transient cavitation；Research shows, under transient cavitation, cell and tissue are higher by the danger of biological damage；The pressure wave of high intensity can make cell injury, rupture, DNA fracture, and blood haemolysis, tissue injury, hemorrhage etc..
Further, described method also includes: be configured the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone respectively；
In the present invention one preferred implementation, preset the scanning acoustic pressure of described ultrasonic microbubble cavitation device according to the size and location of described imaging region and described microvesicle cavitation zone；Described scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure；Wherein, described imaging scanning acoustic pressure is less than described microvesicle cavitation scanning acoustic pressure.
In an embodiment of the present invention, the control parameter of described scanning acoustic pressure includes: tranmitting frequency, emitting voltage, launches pulse length, launches pulse recurrence frequency, launches pulse mode, and line density.
Described tranmitting frequency, its English full name is Frequency, and it is for regulating exomonental mid frequency, and its adjustable extent is usually 1.6 to 6.3MHZ；
Described emitting voltage, its English full name is Transmit Voltage, and by regulation emitting voltage, to control transmitting sound power and mechanical index, under the international standard of diagnostic ultrasound, described transmitting sound power is with IsptaRepresent, Ispta< 720 mW/cm2, mechanical index MI < 1.9；
Launching pulse length, also referred to as pulse width, its English full name is Pulse Length, and it is for regulating exomonental periodicity, and its adjustable extent was usually for 1 ~ 100 cycle；
Launching pulse recurrence frequency, its english abbreviation is PRF: in the case of transmitting pulse length determines, launching pulse recurrence frequency is the time interval between regulation same position twice emitting pulse；
Launching pulse mode, it includes two kinds, i.e. same scan line is used single emission pulse or repeatedly launches pulse；
Line density: during scanning, the ultrasonic scanning line density of transmitting, described scanning density, can the most specifically regulate, not be described in detail at this.
In the embodiment of the invention, the default result of the control parameter of the imaging scanning acoustic pressure of described imaging region is as follows:
The interval of described tranmitting frequency is: 1.7-5.0MHz；
The interval of described emitting voltage is: 5.0-12.0V；
The interval of described transmitting pulse length is: the 1-3 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-30Hz；
Described transmitting pulse mode: impulse ejection at least twice；
The distribution density of the line density of described imaging region is less than the line density of described microvesicle cavitation zone.
The default result of the control parameter of the microvesicle cavitation scanning acoustic pressure of described microvesicle cavitation zone is as follows:
The interval of described tranmitting frequency is: 1.0-6.3MHz；
The interval of described emitting voltage is: 10.0-20.0V；
The interval of described transmitting pulse length is: the 1-50 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-100Hz；
Described transmitting pulse mode: single or multiple impulse ejection；
The line density of described microvesicle cavitation zone is more than the line density of described imaging region.
In an embodiment of the present invention, described method also includes:
In predetermined interval, by control parameter timesharing independent scan imaging region or the microvesicle cavitation zone of respective scanning acoustic pressure.
As in figure 2 it is shown, in the present invention one preferred implementation, described method specifically includes:
Judge whether the attribute of current scanning zone changes, and adjust scanning acoustic pressure and the scanning mode of described ultrasonic microbubble cavitation device according to current scanning zone attribute in real time；So, the demand of user can be met more accurately.
Described current scanning zone attribute generation transformation includes: imaging region is transitioned into microvesicle cavitation zone；Or microvesicle cavitation zone is transitioned into imaging region；
If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, then adjust the control parameter adaptation microvesicle cavitation zone of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to microvesicle cavitation zone；
And restart timing, record the microvesicle cavitation zone scanning persistent period, it is judged that whether the described microvesicle cavitation zone scanning persistent period is equal to system the first predetermined threshold value；
If so, stopping scanning microvesicle cavitation zone, adjust the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
If it is not, continue scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning persistent period；
Described first predetermined threshold value is a fixed numbers, and it can regulate the most voluntarily, in present embodiment, can adjust described system the first predetermined threshold value according to the transmitting pulse mode of described microvesicle cavitation zone and transmitting pulse recurrence frequency；
Described first predetermined threshold value=transmitting pulse number/pulse recurrence frequency.
If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone；
Then adjusting the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
Scanning result according to described imaging region reacquires imaging region and microvesicle cavitation zone, and adjusts the control parameter of the scanning acoustic pressure of described ultrasonic microbubble cavitation device.In present embodiment, described method also includes: scanning imaging region starts, the persistent period of record scanning imaging region, it is judged that whether the scanning persistent period of described scanning imaging region is equal to system the second predetermined threshold value；If so, stop scanning imaging region, adjust the control parameter adaptation microvesicle cavitation zone of scanning acoustic pressure, and be scanned.
Described second predetermined threshold value is similarly a fixed numbers, and it can regulate the most voluntarily, is not described in detail at this.
During described ultrasonic microbubble cavitation device scanning scanning, after scanning first, the area identification delimited, actively judge the area attribute of current scanning zone, and the scanning acoustic pressure of described ultrasonic microbubble cavitation device is adjusted according to described area attribute, the contrast agent microbubble making imaging region is in pressure condition in a low voice, reduces the breakage of microvesicle to increase intensity and the persistent period of microvesicle itself of nonlinear echoes as far as possible；And the contrast agent microbubble of microvesicle cavitation zone is in relatively high sound pressure state, the cavitation biological effect produced by the implosion of microvesicle, reach the purpose for the treatment of；That is: described ultrasonic microbubble cavitation device is made to be provided simultaneously with checking and the function of diagnosis and treatment.
In another embodiment of the present invention, during described method may also include that a scanning, the attribute of the scanning zone that real-time judge is current is imaging region or microvesicle cavitation zone, and adjusts the scanning acoustic pressure of described ultrasonic microbubble cavitation device in real time according to current scanning zone attribute；
During described ultrasonic microbubble cavitation device scanning scanning, after scanning first, the area identification delimited, actively judge the area attribute of current scanning zone, and the scanning acoustic pressure of described ultrasonic microbubble cavitation device is adjusted according to described area attribute, the contrast agent microbubble making imaging region is in pressure condition in a low voice, reduces the breakage of microvesicle to increase intensity and the persistent period of microvesicle itself of nonlinear echoes as far as possible；And the contrast agent microbubble of microvesicle cavitation zone is in relatively high sound pressure state, the cavitation biological effect produced by the implosion of microvesicle, reach the purpose for the treatment of；That is: described ultrasonic microbubble cavitation device is made to be provided simultaneously with checking and the function of diagnosis and treatment.
Further, after a scanning completes, reacquire imaging region and microvesicle cavitation zone, and adjust the scanning acoustic pressure of described ultrasonic microbubble cavitation device.So, the demand of user can be met more accurately.
In both the above embodiment, in one of which scheme, ultrasonic microbubble cavitation device is within the same time, complete independently is to imaging region or the scanning of microvesicle cavitation zone, wherein in another kind of scheme, within the same time period, complete imaging region and the scanning of microvesicle cavitation zone simultaneously.Both the above mode all can make ultrasonic microbubble cavitation device possess two kinds of functions, it is achieved simple, saves and manufactures and use cost, is not described in detail at this.
Shown in Fig. 3, the imaging processing system of the ultrasonic microbubble cavitation device provided in an embodiment of the present invention, described system includes: data acquisition module 100, data processing module 200；
Data acquisition module 100 is used for obtaining imaging region and microvesicle cavitation zone；
Described imaging region and the size of described microvesicle cavitation zone, shape, position can be arbitrarily designated by user, it is also possible to by equipment active obtaining；
In a concrete example of the present invention, described ultrasonic microbubble cavitation device is provided simultaneously with two kinds of functions, and a kind of for traditional ultrasonic scan function, one is emerging technology, ultrasonic microbubble cavitation treatment function.
Under original state, start ultrasonic microbubble cavitation device, it is automatically to needing the region identified to be scanned, and judge whether the scanning result of current scanning zone exists exception according to scanning result, if data acquisition module 100, it is planned to microvesicle cavitation zone, if it is not, be planned to imaging region.
Described ultrasonic microbubble cavitation technique is a kind of emerging technology, when ultrasound wave is by liquid, such as: blood, and the change of liquid acoustic pressure meeting generating period everywhere.Correspondingly, the microvesicle core in liquid also can be with the vibration of supersonic frequency generating period；Under the low sound intensity, the radial oscillation of bubble is vibrated repeatedly by acoustic pressure control, microbubble along about equilibrium radius, will produce radiation pressure and microbeam stream around each microbubble vibrated；Microbeam stream can produce the highest shear stress power near bubble surface, makes bubble deformation even rupture, and causes neighbouring cell or biomacromolecule to be affected, produces certain biological effect；This microvesicle does periodic oscillating movement with its radius for equilibrium radius with acoustic pressure and is referred to as stable cavitation；When effect the sound intensity increase, make bubble oscillation amplitude can comparable with its balance dimension time, the vibration of bubble i.e. then controlled by the inertia of medium about；Cavitation nucleus expanded rapidly in the ultrasonic field negative pressure phase half period, and was drastically contracted to implosion in the malleation phase half period, and this cavitation is referred to as transient cavitation or inertial cavitation.During transient cavitation, bubble oscillation is very fierce, and initial bubble explosion type before this ground expands, and withers the most rapidly；Wither the stage finally, localized hyperthermia, high-pressure phenomena can be produced；Pressure and temperature within Pao can reach hundreds of thousands of atmospheric pressure and thousands of open, additionally with powerful shock wave, high-speed micro-jet, the generation of free radical；The biological activity to Normocellular structure and enzyme that formed of these extreme physical conditions and chemical group has great destruction, but can effectively kill tumor cell simultaneously；Compared with stable cavitation, transient cavitation, in addition to microbubble occurs violent collapse, another difference is that the generation of transient cavitation must have certain threshold value, i.e. when ultrasonic acoustic pressure reaches certain value, just can cause transient cavitation；Research shows, under transient cavitation, cell and tissue are higher by the danger of biological damage；The pressure wave of high intensity can make cell injury, rupture, DNA fracture, and blood haemolysis, tissue injury, hemorrhage etc..
Data processing module 200 is used for: be configured the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone respectively；
In the present invention one preferred implementation, data processing module 200 specifically for: preset the scanning acoustic pressure of described ultrasonic microbubble cavitation device according to the size and location of described imaging region and described microvesicle cavitation zone；Described scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure；Wherein, described imaging scanning acoustic pressure is less than described microvesicle cavitation scanning acoustic pressure.
In an embodiment of the present invention, the control parameter of described scanning acoustic pressure includes: tranmitting frequency, emitting voltage, launches pulse length, launches pulse recurrence frequency, launches pulse mode, and line density.
Described tranmitting frequency, its English full name is Frequency, and it is for regulating exomonental mid frequency, and its adjustable extent is usually 1.6 to 6.3MHZ；
Described emitting voltage, its English full name is Transmit Voltage, and by regulation emitting voltage, to control transmitting sound power and mechanical index, under the international standard of diagnostic ultrasound, described transmitting sound power is with IsptaRepresent, Ispta< 720 mW/cm2, mechanical index MI < 1.9；
Launching pulse length, also referred to as pulse width, its English full name is Pulse Length, and it is for regulating exomonental periodicity, and its adjustable extent was usually for 1 ~ 100 cycle；
Launching pulse recurrence frequency, its english abbreviation is PRF: in the case of transmitting pulse length determines, launching pulse recurrence frequency is the time interval between regulation same position twice emitting pulse；
Launching pulse mode, it includes two kinds, i.e. same scan line is used single emission pulse or repeatedly launches pulse；
Line density: during scanning, the ultrasonic scanning line density of transmitting, described scanning density, can the most specifically regulate, not be described in detail at this.
In the embodiment of the invention, the default result of the control parameter of the imaging scanning acoustic pressure of described imaging region is as follows:
The interval of described tranmitting frequency is: 1.7-5.0MHz；
The interval of described emitting voltage is: 5.0-12.0V；
The interval of described transmitting pulse length is: the 1-3 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-30Hz；
Described transmitting pulse mode: impulse ejection at least twice；
The distribution density of the line density of described imaging region is less than the line density of described microvesicle cavitation zone.
The default result of the control parameter of the microvesicle cavitation scanning acoustic pressure of described microvesicle cavitation zone is as follows:
The interval of described tranmitting frequency is: 1.0-6.3MHz；
The interval of described emitting voltage is: 10.0-20.0V；
The interval of described transmitting pulse length is: the 1-50 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-100Hz；
Described transmitting pulse mode: single or multiple impulse ejection；
The line density of described microvesicle cavitation zone is more than the line density of described imaging region.
Further, in an embodiment of the present invention, data processing module 200 is additionally operable to: in predetermined interval, by control parameter timesharing independent scan imaging region or the microvesicle cavitation zone of respective scanning acoustic pressure.
In the present invention one preferred implementation, data processing module 200 specifically for:
Judge whether the attribute of current scanning zone changes, and adjust scanning acoustic pressure and the scanning mode of described ultrasonic microbubble cavitation device according to current scanning zone attribute in real time；So, the demand of user can be met more accurately.
Described current scanning zone attribute generation transformation includes: imaging region is transitioned into microvesicle cavitation zone；Or microvesicle cavitation zone is transitioned into imaging region；
If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, data processing module 200 is for adjusting the control parameter adaptation microvesicle cavitation zone of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to microvesicle cavitation zone；And restart timing, record the microvesicle cavitation zone scanning persistent period, it is judged that whether the described microvesicle cavitation zone scanning persistent period is equal to system the first predetermined threshold value；
If so, stopping scanning microvesicle cavitation zone, adjust the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
If it is not, continue scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning persistent period；
Described first predetermined threshold value is a fixed numbers, and it can regulate the most voluntarily, in present embodiment, can adjust described system the first predetermined threshold value according to the transmitting pulse mode of described microvesicle cavitation zone and transmitting pulse recurrence frequency；
Described first predetermined threshold value=transmitting pulse number/pulse recurrence frequency.
If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone；
Data processing module 200 is used for: adjust the control parameter adaptation imaging region of scanning acoustic pressure, and after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
Scanning result according to described imaging region reacquires imaging region and microvesicle cavitation zone, and adjusts the control parameter of the scanning acoustic pressure of described ultrasonic microbubble cavitation device.
In present embodiment, data processing module 200 is additionally operable to after scanning imaging region starts, the persistent period of record scanning imaging region, it is judged that whether the scanning persistent period of described scanning imaging region is equal to system the second predetermined threshold value；If so, stop scanning imaging region, adjust the control parameter adaptation microvesicle cavitation zone of scanning acoustic pressure, and be scanned.
Described second predetermined threshold value is similarly a fixed numbers, and it can regulate the most voluntarily, is not described in detail at this.
During described ultrasonic microbubble cavitation device scanning scanning, after data processing module 200 is according to scanning first, the area identification delimited, actively judge the area attribute of current scanning zone, and the scanning acoustic pressure of described ultrasonic microbubble cavitation device is adjusted according to described area attribute, the contrast agent microbubble making imaging region is in pressure condition in a low voice, reduces the breakage of microvesicle to increase intensity and the persistent period of microvesicle itself of nonlinear echoes as far as possible；And the contrast agent microbubble of microvesicle cavitation zone is in relatively high sound pressure state, the cavitation biological effect produced by the implosion of microvesicle, reach the purpose for the treatment of；That is: described ultrasonic microbubble cavitation device is made to be provided simultaneously with checking and the function of diagnosis and treatment.
In another embodiment of the present invention, data processing module 200 is additionally operable to: during a scanning, the attribute of the scanning zone that real-time judge is current is imaging region or microvesicle cavitation zone, and adjusts the scanning acoustic pressure of described ultrasonic microbubble cavitation device in real time according to current scanning zone attribute；
During described ultrasonic microbubble cavitation device scanning scanning, after data processing module 200 is according to scanning first, the area identification delimited, actively judge the area attribute of current scanning zone, and the scanning acoustic pressure of described ultrasonic microbubble cavitation device is adjusted according to described area attribute, the contrast agent microbubble making imaging region is in pressure condition in a low voice, reduces the breakage of microvesicle to increase intensity and the persistent period of microvesicle itself of nonlinear echoes as far as possible；And the contrast agent microbubble of microvesicle cavitation zone is in relatively high sound pressure state, the cavitation biological effect produced by the implosion of microvesicle, reach the purpose for the treatment of；That is: described ultrasonic microbubble cavitation device is made to be provided simultaneously with checking and the function of diagnosis and treatment.
Further, after a scanning completes, data processing module 200 reacquires imaging region and microvesicle cavitation zone, and adjusts the scanning acoustic pressure of described ultrasonic microbubble cavitation device.So, the demand of user can be met more accurately.
In both the above embodiment, in one of which scheme, ultrasonic microbubble cavitation device is within the same time, complete independently is to imaging region or the scanning of microvesicle cavitation zone, wherein in another kind of scheme, within the same time period, complete imaging region and the scanning of microvesicle cavitation zone simultaneously.Both the above mode all can make ultrasonic microbubble cavitation device possess two kinds of functions, it is achieved simple, saves and manufactures and use cost, is not described in detail at this.
Shown in Fig. 4 A to Fig. 4 C, the present invention one should in aforementioned manners and the ultrasonic microbubble cavitation device of system；
This ultrasonic microbubble cavitation device is in use, user operation for convenience, set up main operation interface and corresponding auxiliary operation interface, during use, user can touch or click on the corresponding button on described operation interface by peripheral apparatus, afterwards, ultrasonic microbubble cavitation device can perform the instruction that the corresponding button represents automatically, automatically uses said method and system to realize the function of ultrasonic microbubble cavitation device on backstage.
As shown in Figure 4 A, it it is the main operation interface of a ultrasonic microbubble cavitation device, on this display interface, it is provided with some buttons being automatically obtained difference in functionality, wherein, after entering icon " CBI ", it can cut imaging region automatically, accordingly, described imaging region can occur multiple auxiliary display interface accordingly, and one of them auxiliary display interface is as shown in Figure 4 B；After entering icon " Vflash ", it can be cut into microvesicle cavitation zone automatically, and accordingly, described imaging region can occur multiple auxiliary display interface accordingly, and one of them auxiliary display interface is as shown in Figure 4 C.
As shown in Figure 4 B, after scanning completes as regions, microvesicle cavitation zone can be automatically switched to be scanned according to scanning result, it is also possible to selected to enter into microvesicle cavitation zone by user and be scanned, in this example, " VFLASH " button, and " exiting " button are set at CBI interface, so, user can select next step process as required voluntarily.
Such as Fig. 4 C, after entering into VFLASH interface, at VFLASH interface, START button is set, when after operation START button, " persistent period " shows the scanning time schedule of current record i.e. automatically, when " scanning time " progress bar is shown as full, represent that the described microvesicle cavitation zone scanning persistent period is equal to system the first predetermined threshold value, accordingly, also relative set is set at VFLASH interface and " exits " button, " end " button and " CBI " button, with this, according to user's needs, select next step process voluntarily, be not described in detail at this.
Shown in Fig. 5 A, 5B, the embodiment of the invention uses imaging region and the sound field three-dimensional distribution map of microvesicle cavitation zone of said system acquisition；
By diagram: all measurement result coincidence theory are expected；Sound field meets Gauss distribution in Y direction；Arc battle array is in the distribution of X-axis: be half period cosine distribution in microvesicle cavitation zone sampling window, is not distributed rectangular completely；The most weak, substantially in Gauss distribution along with distance windowsill more far sound field outside window；Linear array is in the distribution of X-axis: be distributed rectangular in microvesicle cavitation zone sampling window；The most weak, in Gauss distribution along with distance windowsill more far sound field outside window.
Those skilled in the art is it can be understood that arrive, for convenience and simplicity of description, the system of foregoing description and the specific works process of module, and the corresponding process in preceding method embodiment can reference mutually, do not repeat them here.
In sum, the image processing method of the ultrasonic microbubble cavitation device of the present invention and processing system, by dividing different regions, and preset corresponding parameter, can be so that ultrasonic microbubble cavitation device possess two kinds of functions, it is achieved simple, save and manufacture and use cost.
For convenience of description, it is divided into various module to be respectively described with function when describing apparatus above.Certainly, the function of each module can be realized in same or multiple softwares and/or hardware when implementing the application.
As seen through the above description of the embodiments, those skilled in the art is it can be understood that can add the mode of required general hardware platform by software to the application and realize.Based on such understanding, the part that prior art is contributed by the technical scheme of the application the most in other words can embody with the form of software product, this software product can be saved in preservation medium, such as ROM/RAM, magnetic disc, CD etc., including some instructions with so that a computer equipment (can be personal computer, Information Push Server, or the network equipment etc.) perform each embodiment of the application or the method described in some part of embodiment.
Device embodiments described above is only schematically, the wherein said module illustrated as separating component can be or may not be physically separate, the parts shown as module can be or may not be physical module, i.e. may be located at a place, or can also be distributed on multiple mixed-media network modules mixed-media.Some or all of module therein can be selected according to the actual needs to realize the purpose of present embodiment scheme.Those of ordinary skill in the art, in the case of not paying creative work, are i.e. appreciated that and implement.
The application can be described in the general context of computer executable instructions, such as program module.Usually, program module includes performing particular task or realizing the routine of particular abstract data type, program, object, assembly, data structure etc..The application can also be put into practice in a distributed computing environment, in these distributed computing environment, the remote processing devices connected by communication network perform task.In a distributed computing environment, during program module may be located at the local and remote computer preservation medium including preservation equipment.
It is to be understood that, although this specification is been described by according to embodiment, but the most each embodiment only comprises an independent technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should be using description as an entirety, technical scheme in each embodiment can also form, through appropriately combined, other embodiments that it will be appreciated by those skilled in the art that.
The a series of detailed description of those listed above is only for illustrating of the feasibility embodiment of the present invention; they also are not used to limit the scope of the invention, and all equivalent implementations or changes made without departing from skill of the present invention spirit should be included within the scope of the present invention.
Claims (10)
1. the image processing method of a ultrasonic microbubble cavitation device, it is characterised in that said method comprising the steps of:
Obtain imaging region and microvesicle cavitation zone；
Respectively the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone is configured；
The control parameter of described scanning acoustic pressure includes: tranmitting frequency, emitting voltage, launches pulse length, launches pulse recurrence frequency, launches pulse mode, and line density；
In predetermined interval, by control parameter timesharing independent scan imaging region or the microvesicle cavitation zone of respective scanning acoustic pressure.
The image processing method of ultrasonic microbubble cavitation device the most according to claim 1, it is characterised in that " being configured the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone respectively " specifically includes:
Size and location according to described imaging region and described microvesicle cavitation zone preset the scanning acoustic pressure of described ultrasonic microbubble cavitation device；Described scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure；
Wherein, described imaging scanning acoustic pressure is less than described microvesicle cavitation scanning acoustic pressure.
The image processing method of ultrasonic microbubble cavitation device the most according to claim 2, it is characterised in that
The control parameter of the imaging scanning acoustic pressure of described imaging region specifically includes:
The interval of described tranmitting frequency is: 1.7-5.0MHz；
The interval of described emitting voltage is: 5.0-12.0V；
The interval of described transmitting pulse length is: the 1-3 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-30Hz；
Described transmitting pulse mode: impulse ejection at least twice；
The distribution density of the line density of described imaging region is less than the line density of described microvesicle cavitation zone；
The control parameter of the microvesicle cavitation scanning acoustic pressure of described microvesicle cavitation zone specifically includes:
The interval of described tranmitting frequency is: 1.0-6.3MHz；
The interval of described emitting voltage is: 10.0-20.0V；
The interval of described transmitting pulse length is: the 1-50 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-100Hz；
Described transmitting pulse mode: single or multiple impulse ejection；
The line density of described microvesicle cavitation zone is more than the line density of described imaging region.
The image processing method of ultrasonic microbubble cavitation device the most according to claim 1, it is characterised in that " in predetermined interval, by control parameter independent scan imaging region or the microvesicle cavitation zone of respective scanning acoustic pressure " specifically includes:
Judge whether the attribute of current scanning zone changes,
Described current scanning zone attribute generation transformation includes: imaging region is transitioned into microvesicle cavitation zone；Or microvesicle cavitation zone is transitioned into imaging region；
If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, then adjust the control parameter adaptation microvesicle cavitation zone of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to microvesicle cavitation zone；
And restart timing, record the microvesicle cavitation zone scanning persistent period, it is judged that whether the described microvesicle cavitation zone scanning persistent period is equal to system the first predetermined threshold value；
If so, stopping scanning microvesicle cavitation zone, adjust the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
If it is not, continue scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning persistent period；
If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone；
Then adjusting the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
Scanning result according to described imaging region reacquires imaging region and microvesicle cavitation zone, and adjusts the control parameter of the scanning acoustic pressure of described ultrasonic microbubble cavitation device.
The image processing method of ultrasonic microbubble cavitation device the most according to claim 4, it is characterised in that described method also includes:
Transmitting pulse mode and transmitting pulse recurrence frequency according to described microvesicle cavitation zone adjust described system the first predetermined threshold value.
6. the imaging processing system of a ultrasonic microbubble cavitation device, it is characterised in that described system includes:
Data acquisition module, is used for obtaining imaging region and microvesicle cavitation zone；
Data processing module, for being configured the control parameter of the scanning acoustic pressure of imaging region and microvesicle cavitation zone respectively；The control parameter of described scanning acoustic pressure includes: tranmitting frequency, emitting voltage, launches pulse length, launches pulse recurrence frequency, launches pulse mode, and line density；
In predetermined interval, by control parameter timesharing independent scan imaging region or the microvesicle cavitation zone of respective scanning acoustic pressure.
The imaging processing system of ultrasonic microbubble cavitation device the most according to claim 6, it is characterised in that
Described data processing module specifically for: preset the scanning acoustic pressure of described ultrasonic microbubble cavitation device according to the size and location of described imaging region and described microvesicle cavitation zone；Described scanning acoustic pressure includes: imaging scanning acoustic pressure and microvesicle cavitation scanning acoustic pressure.
The imaging processing system of ultrasonic microbubble cavitation device the most according to claim 7, it is characterised in that
The control parameter of the imaging scanning acoustic pressure of described imaging region specifically includes:
The interval of described tranmitting frequency is: 1.7-5.0MHz；
The interval of described emitting voltage is: 5.0-12.0V；
The interval of described transmitting pulse length is: the 1-3 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-30Hz；
Described transmitting pulse mode: impulse ejection at least twice；
The distribution density of the line density of described imaging region is less than the line density of described microvesicle cavitation zone；
The control parameter of the microvesicle cavitation scanning acoustic pressure of described microvesicle cavitation zone specifically includes:
The interval of described tranmitting frequency is: 1.0-6.3MHz；
The interval of described emitting voltage is: 10.0-20.0V；
The interval of described transmitting pulse length is: the 1-50 cycle；
The interval of described transmitting pulse recurrence frequency is: 10-100Hz；
Described transmitting pulse mode: single or multiple impulse ejection；
The line density of described microvesicle cavitation zone is more than the line density of described imaging region.
The imaging processing system of ultrasonic microbubble cavitation device the most according to claim 6, it is characterised in that
Described data processing module specifically for:
Judge whether the attribute of current scanning zone changes,
Described current scanning zone attribute generation transformation includes: imaging region is transitioned into microvesicle cavitation zone；Or microvesicle cavitation zone is transitioned into imaging region；
If the attribute of current scanning zone is transitioned into microvesicle cavitation zone from imaging region, then adjust the control parameter adaptation microvesicle cavitation zone of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to microvesicle cavitation zone；
And restart timing, record the microvesicle cavitation zone scanning persistent period, it is judged that whether the described microvesicle cavitation zone scanning persistent period is equal to system the first predetermined threshold value；
If so, stopping scanning microvesicle cavitation zone, adjust the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
If it is not, continue scanning microvesicle cavitation zone, and record the microvesicle cavitation zone scanning persistent period；
If the attribute of current scanning zone is transitioned into imaging region from microvesicle cavitation zone；
Then adjusting the control parameter adaptation imaging region of scanning acoustic pressure, after the control parameter adjustment of described scanning acoustic pressure completes, the probe that automatically switches is scanned to imaging region；
Scanning result according to described imaging region reacquires imaging region and microvesicle cavitation zone, and adjusts the control parameter of the scanning acoustic pressure of described ultrasonic microbubble cavitation device.
The imaging processing system of ultrasonic microbubble cavitation device the most according to claim 9, it is characterised in that described data processing module is additionally operable to:
Transmitting pulse mode and transmitting pulse recurrence frequency according to described microvesicle cavitation zone adjust described system the first predetermined threshold value.
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