CN105938731B - Neutron-capture therapy device - Google Patents
Neutron-capture therapy device Download PDFInfo
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- CN105938731B CN105938731B CN201610118023.1A CN201610118023A CN105938731B CN 105938731 B CN105938731 B CN 105938731B CN 201610118023 A CN201610118023 A CN 201610118023A CN 105938731 B CN105938731 B CN 105938731B
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- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 48
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims abstract description 179
- 229910052796 boron Inorganic materials 0.000 claims abstract description 179
- 230000001678 irradiating effect Effects 0.000 claims abstract description 11
- 238000001514 detection method Methods 0.000 claims description 30
- 238000012360 testing method Methods 0.000 claims description 29
- 230000033228 biological regulation Effects 0.000 claims description 14
- 239000002245 particle Substances 0.000 description 29
- 206010028980 Neoplasm Diseases 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 201000011510 cancer Diseases 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 230000005251 gamma ray Effects 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229910052790 beryllium Inorganic materials 0.000 description 1
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000003831 deregulation Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 229910001338 liquidmetal Inorganic materials 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/06—Generating neutron beams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- High Energy & Nuclear Physics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The present invention provides a kind of neutron-capture therapy device, and it can realize the raising of the reliability of boron neutron-capture therapy.The neutron-capture therapy device (1) of the present invention irradiates neutron beam (N) to irradiated body (M), reacted the boron in irradiated body (M) and neutron, the neutron-capture therapy device (1) is following structure, is possessed：Neutron beam irradiation portion (4), neutron beam (N) is irradiated to irradiated body (M)；And boron concentration mensuration portion (32), the concentration of boron when irradiating neutron beam (N) by neutron beam irradiation portion (4) in the real time measure irradiated body (M).
Description
Technical field
The application advocate based on March 5th, 2015 in Japanese publication Japanese patent application 2015-043840 it is preferential
Power.The full content of the Japanese publication is by reference to being applied at the application.
The present invention relates to a kind of neutron-capture therapy device.
Background technology
As one kind of the radiation cure in cancer treatment etc., have and carried out by the irradiation of neutron beam in the boron of cancer treatment
Son catches therapy (BNCT；Boron Neutron Capture Therapy).In boron neutron-capture therapy, absorb cancer cell
Boron and neutron beam is irradiated to affected part, boron and neutron is produced reaction to destroy cancer cell in cancer cell.
The neutron-capture therapy device for carrying out the boron neutron-capture therapy possesses：Charged particle beam generating unit, generation are powered
The particle beams；And neutron beam generating unit, by the way that in target, charged particle beam irradiation is generated into neutron beam (such as referenced patent document 1).
In the neutron-capture therapy device, measure is irradiated to the current value of the charged particle beam of target, thus calculates and is irradiated in real time
The neutron beam of patient.
Patent document 1：International Publication No. 2012/014671
In boron neutron-capture therapy, treated due to the reaction by neutron beam and the boron of patient's body, therefore i.e.
Make real-time and accurately to have grasped the neutron dose for being irradiated to patient, can when the concentration of the boron of patient's body is not according to treatment plan
Also treatment can not can be performed according to treatment plan.
The content of the invention
It is an object of the invention to provide a kind of neutron of the raising for the reliability that can realize boron neutron-capture therapy to catch
Catch Treatment subtraction units.
The present invention is to irradiate neutron beam, the neutron capture for being reacted the boron in irradiated body and neutron to irradiated body
Therapy device, it possesses：Neutron beam irradiation portion, neutron beam is irradiated to irradiated body；And boron concentration mensuration portion, irradiated by neutron beam
The concentration of boron when neutron beam is irradiated in portion in the real time measure irradiated body.
In the neutron-capture therapy device, due to irradiation neutron beam when the real time measure irradiated body in boron concentration,
Therefore measurement result is based on, will appreciate that whether the concentration of the boron in irradiated body plans according to irradiation.As a result, it can realize
The raising of the reliability of boron neutron-capture therapy.
Also, boron concentration mensuration portion can also be following structure, have：Gamma-rays test section, detection with from irradiated body
The relevant information of the gamma-rays of interior releasing；And boron concentration calculating part, it is relevant with gamma-rays from being detected by gamma-rays test section
Information calculate irradiated body in boron concentration.Irradiation neutron beam and boron and neutron in irradiated body produce γ when being reacted
Ray.In neutron capture Treatment subtraction units, the detection information relevant with the gamma-rays released out of irradiated body, from what is detected
The information relevant with gamma-rays calculates the boron concentration in irradiated body.Thus, when irradiating neutron beam, detection is relevant with gamma-rays
Information, in real time calculate irradiated body in boron concentration.
Also, gamma-rays test section can also be following structure, have noise remove portion, from being released from irradiation body
The relevant information of gamma-rays removes the information relevant with the gamma-rays as noise.According to the structure, gone by noise remove portion
Except the information relevant with the gamma-rays as noise, therefore improve the inspection of the information relevant with the gamma-rays released out of irradiation body
Precision is surveyed, so as to improve the accuracy of detection of the concentration of boron.
Gamma-rays test section possesses：Collimater, formed with the reducing diameter part to diminish from the lateral outlet side internal diameter of entrance and
It is connected to reducing diameter part and becomes the through hole of big wide diameter portion from the lateral outlet side internal diameter of entrance；1st detector, with going out for through hole
Mouth is arranged opposite, the 1st gamma-rays information that the detection information relevant with gamma-rays is included；And the 2nd detector, it is configured at expanding
The internal face in portion, the 2nd gamma-rays information that the detection information relevant with gamma-rays is included, noise remove portion can be from the 1st γ
Ray information, which removes, compares the 1st gamma-rays information and the 2nd gamma-rays information and the common information relevant with gamma-rays, by
This removes the information relevant with the gamma-rays as noise.According to the 1st detector, except relevant with by the gamma-rays of through hole
Information outside, also detect with colliding the internal face of through hole and scatter and information that the gamma-rays of energy reduction is relevant etc..
2nd detector is arranged at the internal face of the wide diameter portion of through hole, therefore does not detect the γ extremely exported by the entrance of through hole and penetrate
Line, but the gamma-rays that detection is passed through in a manner of crossing wide diameter portion.In noise remove portion, removed from the 1st gamma-rays information
It will be compared by the 1st detector the 1st gamma-rays information detected and the 2nd gamma-rays information detected by the 2nd detector
And both common gamma-rays information.Thereby, it is possible to remove the information relevant with the gamma-rays as noise, so that gamma-rays
Accuracy of detection improve, make boron concentration accuracy of detection improve.
Also, neutron-capture therapy device can also be following structure, be also equipped with：Treatment plan information storage part, storage
The information relevant with treatment plan；Boron dispensing portion, boron is launched to irradiated body；And control unit, the action in control boron dispensing portion, with
The setting value of concentration comprising the boron in irradiated body in the relevant information for the treatment of plan, control unit control boron dispensing portion, so as to
It is inconsistent relative to the setting value of the concentration of the boron included in the information relevant with treatment plan in the concentration of the boron determined
Or when not falling within the poor scope of regulation, adjust the amount for the boron launched to irradiated body.Thus, though irradiation neutron beam N when quilt
The concentration of boron in irradiation body changes with deviateing from treatment plan is larger, can also be adjusted in a manner of eliminating its variation illuminated
The concentration of internal boron.As a result, it can be treated according to treatment plan.
Also, neutron-capture therapy device can also be following structure, be also equipped with：Treatment plan information storage part, storage
The information relevant with treatment plan；And control unit, the action of neutron beam irradiation portion is controlled, is wrapped in the information relevant with treatment plan
The setting value of concentration containing the boron in irradiated body, control unit control neutron beam irradiation portion, so as in the concentration of the boron determined
Relative to the setting value of the concentration of the boron included in the information relevant with treatment plan it is inconsistent or do not fall within regulation difference model
When enclosing interior, the time from neutron beam irradiation portion irradiation neutron beam is adjusted.Thus, although the concentration of the boron in irradiated body
When changing the concentration for the boron that can not also adjust in irradiated body with deviateing from treatment plan is larger, it can also be entered according to treatment plan
Row treatment.Even if adjustment also needs to the amount for the boron launched in irradiated body untill the concentration of the boron in irradiated body is adjusted
Want a certain degree of time.Therefore, the concentration of the boron at the end of close on treatment time in irradiated body is larger from treatment plan
When deviateing ground variation, the concentration that the boron in irradiated body is adjusted within treatment time is more difficult.Then, neutron is irradiated by adjusting
The time of beam, adjust the reacting dose of neutron beam and the boron in irradiated body.As a result, even if the boron in irradiated body is not adjusted
Concentration, it can also be treated according to treatment plan.
Also, neutron-capture therapy device can also be following structure, be also equipped with：Treatment plan information storage part, storage
The information relevant with treatment plan；And control unit, the action of neutron beam irradiation portion is controlled, is wrapped in the information relevant with treatment plan
The setting value of concentration containing the boron in irradiated body, control unit control neutron beam irradiation portion, so as in the concentration of the boron determined
Relative to the setting value of the concentration of the boron included in the information relevant with treatment plan it is inconsistent or do not fall within regulation difference model
When enclosing interior, stop the irradiation of the neutron beam from neutron beam irradiation portion.Adjusting the amount that boron is launched to irradiated body, adjusting from neutron
When beam irradiation portion irradiates the time of neutron beam, if the concentration that can not tackle the boron in irradiated body changes significantly from treatment plan
When, continue to treat, then may not turn into the treatment according to treatment plan.Controlled by the irradiation and interruption that stop neutron beam
Treat, the deterioration that can prevent actual therapeutic from being changed from treatment plan.
The effect of invention
In accordance with the invention it is possible to a kind of concentration due to that can grasp the boron in irradiated body in real time is provided, therefore can be real
The neutron-capture therapy device of the raising of the reliability of existing boron neutron-capture therapy.
Brief description of the drawings
Fig. 1 is the schematic diagram for the neutron-capture therapy device for representing one embodiment of the present invention.
Fig. 2 is the block diagram for the neutron-capture therapy device for representing one embodiment of the present invention.
Fig. 3 is the sectional view for representing gamma-rays test section.
Fig. 4 is the flow chart for the control operation for representing control unit.
The explanation of symbol
1 ... neutron-capture therapy device, 4 ... neutron beam irradiation portions, 17 ... boron dispensing portions, 32 ... boron concentration mensuration portions,
33 ... gamma-rays test sections, 35 ... gamma-rays detection collimater, 35a ... through holes, 35b ... entrances, 35c ... outlets, 35d ...
Reducing diameter part, 35e ... wide diameter portions, 36 ... the 1st detectors, 37 ... the 2nd detectors, 38 ... noise remove portions, M ... patients are (illuminated
Body), N ... neutron beams.
Embodiment
Hereinafter, the preferred embodiment of the present invention is described in detail refer to the attached drawing.In addition, in the drawings to identical
Part or appropriate section add identical symbol and omit repeat specification.
Neutron-capture therapy device 1 shown in Fig. 1 and Fig. 2 is the device that cancer treatment is carried out using boron neutron-capture therapy.
In neutron-capture therapy device 1, for example, to dispensing have comprising boron (10B patient (irradiated body) M of medicament) tumour irradiation
Neutron beam N.
Neutron-capture therapy device 1 possesses：Accelerator 2, beam transmission device 3, neutron beam irradiation portion 4 and boron dispensing portion
17.Accelerator 2 is, for example, cyclotron.Accelerator 2 accelerates the charged particles such as hydrogen ion, and matter is manufactured as charged particle beam P
Beamlet (proton beamlets).This accelerator 2 for example with generation beam radius be 40mm, 60kW (=30MeV × 2mA) it is powered
Particle beams P ability.In addition, accelerator is not limited to cyclotron, such as can also add for synchrotron, synchronous convolution
Fast device, linear accelerator etc..
The charged particle beam P projected from accelerator 2 is directed to beam transmission device 3.Beam transmission device 3 has：Penetrate
Beam guide tube 5, quadrupole electromagnet 6, current monitor 7 and scanning electro-magnet 8.One side of beam conduit 5 is connected with accelerator 2,
Neutron beam irradiation portion 4 is connected with the another side of beam conduit 5.Charged particle beam P by inside beam conduit 5 to neutron beam
Irradiation portion 4 is advanced.
Quadrupole electromagnet 6 is provided with multiple along beam conduit 5, uses electromagnet to carry out charged particle beam P beam axial adjustment.
Current monitor 7 detects charged particle beam P current value (electric charge, exposure dose rate) in real time.Not shadow is used in current monitor 7
Ring charged particle beam P and the non-damage type DCCT (DC Current Transformer) of electric current can be determined.That is, current monitor
7 can not contact charged particle beam P (in a non contact fashion) and detect charged particle beam P current value.Current monitor 7 will be examined
Result is surveyed to export to control unit 20 described later.In addition, " close rate " refers to the dosage of time per unit.
Specifically, in order to which accuracy detects the charged particle beam P's for the target 9 for being irradiated in neutron beam irradiation portion 4 higher
Current value, current monitor 7 are arranged at the downstream (charged particle beam P downstream) of quadrupole electromagnet 6 and in scanning electromagnetism
The immediately front of iron 8 excludes the influence of quadrupole electromagnet 6.That is, it is because scanning electro-magnet 8 is scanned to target 9 in order to avoid right all the time
Identical place irradiation charged particle beam P, therefore need when current monitor 7 is disposed in into the downstream of scanning electro-magnet 8 big
The current monitor 7 of type.In contrast, the upstream side by the way that current monitor 7 to be arranged to scanning electro-magnet 8, can make electricity
Flow monitor 7 minimizes.
Scanning electro-magnet 8 scans charged particle beam P, and controls irradiations of the charged particle beam P to target 9.The scanning electro-magnet 8
Control irradiation positions of the charged particle beam P to target 9.
Neutron beam irradiation portion 4 is radiated on target 9 by charged particle beam P to produce neutron beam N, and neutron is projected to patient M
Beam N.Neutron beam irradiation portion 4 possesses：Target 9, shield 10, decelerating material 11 and collimater 12.
Also, neutron-capture therapy device 1 possesses control unit 20.Control unit 20 is by CPU [Central Processing
Unit], ROM [Read Only Memory], RAM [Random Access Memory] etc. form, and Comprehensive Control neutron is caught
Catch the electronic control unit of therapy device 1.
Target 9 receives charged particle beam P irradiation and generates neutron beam N.In this target 9 for example by beryllium (Be), lithium (Li), tantalum
(Ta) or tungsten (W) etc. is formed, such as is diametrically the discoideus of 160mm.Target 9 is not limited to discoideus, or other are solid
Shape, liquid material (liquid metals) can also be used.
The neutron beam N that decelerating material 11 makes to generate in target 9 slows down and reduces neutron beam N energy.Decelerating material 11 has
Stepped construction, the stepped construction include：1st decelerating material 11A, the fast neutron for being contained in neutron beam N is mainly set to slow down；And the
2 decelerating material 11B, the epithermal neutron for being contained in neutron beam N is mainly set to slow down.
Shield 10 shields caused neutron beam N, the gamma-rays generated with neutron beam N generation on target 9
The gamma-rays generated when being slowed down Deng secondary radiation and neutron beam N by decelerating material 11 in decelerating material 11 etc. is secondary to be put
Ray, suppress these radioactive ray and released to the exposure cell side for having patient M.Shield 10 is set in a manner of surrounding decelerating material 11
Put.
Collimater 12 carries out shaping, and the opening 12a passed through with neutron beam N to neutron beam N irradiation field.Collimater 12
E.g. center has opening 12a block parts.
To patient M irradiate neutron beam N when, boron dispensing portion 17 to patient M launch comprising boron (10B medicament).Boron dispensing portion 17
Transmitted with the unloading part for sending out the medicament comprising boron, the pin portion for pointing to patient and connection unloading part and pin portion comprising boron
Transport part of medicament etc..Due to being reduced by the reaction with neutron beam N and the boron in patient's M bodies, therefore boron dispensing portion 17 is being shone
Boron is supplied to patient M when hitting beamlet N and supplemented.
Here, neutron-capture therapy device 1 possesses neutron beam test section 31 and boron concentration mensuration portion 32.Neutron beam test section
31 are used for the neutron beam that the real time measure is irradiated to patient M when irradiating neutron beam by neutron beam irradiation portion 4.Neutron beam test section 31
Such as detection passes through the opening 12a of collimater 12 neutron beam N in real time.
Neutron beam test section 31 has scintillator (not shown) and photodetector.Scintillator be by the radioactive ray of injection (in
Beamlet N, gamma-rays) be converted to the fluorophor of light.Scintillator according to the dosage of the radioactive ray of injection and crystal inside turn into excite
State, produce passage of scintillation light.6Li glass scintillators, LiCAF scintillators, the plastics for being coated with 6LiF can be used as scintillator
Scintillator, 6LiF/ZnS scintillators etc..Photodetector detection light as caused by scintillator.It can such as be used as photodetector
The various light sensing devices such as photomultiplier tube, photoelectric tube.Photodetector exports electric signal (detection when light detects to control unit 20
Signal).
Boron concentration mensuration portion 32 is used for the boron when irradiating neutron beam by neutron beam irradiation portion 4 in the real time measure patient M bodies
Concentration.Detect by the gamma-rays (478kev) that the reaction of neutron and boron generates and determine boron concentration in boron concentration mensuration portion 32.Make
For boron concentration mensuration portion 32 gamma-rays of measure monoergic can be used to determine the boron deregulation measuring system (PG of boron concentration distribution
(Prompt-γ)-SPECT).Boron concentration mensuration portion 32 has：Gamma-rays test section 33, detect with being released inside patient M
The relevant information of gamma-rays；And boron concentration calculating part 34, it is relevant with gamma-rays from being detected by gamma-rays test section 33
Information calculates the boron concentration in patient's M bodies.
Scintillator, ionisation chamber and other various gamma-rays detection devices can be used as gamma-rays test section 33.At this
In embodiment, gamma-rays test section 33 is configured near patient M tumour G.Such as it is 30cm or so to be configured at from patient M
Position.
As shown in figure 3, gamma-rays test section 33 possesses gamma-rays detection collimater 35, the detection of the 1st detector the 36, the 2nd
Device 37 and noise remove portion 38.Formed with the through hole run through along center line C1 directions in gamma-rays detection collimater 35
35a.Through hole 35a has on center line C1 directions：Reducing diameter part 35d, as and then internal diameter internally preceding from entrance 35b becomes
It is small；And wide diameter portion 35e, with before from inside to outlet 35c and then internal diameter becomes big.In the section along center line C1, undergauge
Portion 35d internal face by from entrance 35b side outlet 35c sides close to center line C1 in a manner of formed, wide diameter portion 35e internal face
By from entrance 35b side outlet 35c sides away from center line C1 in a manner of formed.The through hole of gamma-rays detection collimater 35
The direction that 35a center line C1 intersects along the direction of advance with neutron beam N configures.
1st detector 36 is arranged opposite with the through hole 35a of collimater 35 outlet 35c with gamma-rays detection.In the 1st inspection
Survey in device 36 and detect：Gamma-rays GR1, gamma-rays GR1 enter through hole from gamma-rays detection with the entrance 35b of collimater 35
35a, not with through hole 35a internal face collision, come out from gamma-rays detection with the outlet 35c of collimater 35, and detected to the 1st
Device 36 advances；And gamma-rays GR2, GR3, gamma-rays GR2, GR3 run through partially by gamma-rays detection collimater 35
Hole 35a.
2nd detector 37 is configured at the through hole 35a of gamma-rays detection collimater 35 wide diameter portion 35e internal face,
And to be configured in a manner of surrounding the side (direction orthogonal with center line C1) of the 1st detector 36.In 2nd detector 37, no
Detect gamma-rays GR1, detection gamma-rays GR2, GR3.
Noise remove portion 38 electrically connects with the 1st detector 36, the 2nd detector 37 and boron concentration calculating part 34.Noise remove
Portion 38 removes the information relevant with the gamma-rays as noise from the relevant information of the gamma-rays with being released from inside patient M.
Noise remove portion 38 from the 1st gamma-rays information remove will be exported from the 1st detector 36 the 1st gamma-rays information (gamma-rays GR1~
GR3 compare) and from the 2nd gamma-rays information (gamma-rays GR2, GR3) of the 2nd detector 37 output and common have with gamma-rays
The information of pass, thus remove the information relevant with gamma-rays GR2, GR3 as noise.
Collided with the 1st detector and scatter and inject the 2nd detector gamma-rays, with the 2nd detector collide and scatter and
The gamma-rays for injecting the 1st detector is detected in synchronization by both the 1st detector 36 and the 2nd detector 37.In noise remove
In portion 38, gone in synchronization by the common signal that both the 1st detector 36 and the 2nd detector 37 detect as noise
Remove.After the information relevant with the gamma-rays as noise is removed in noise remove portion 38, the information relevant with gamma-rays is defeated
For boron concentration calculating part 34.
Boron concentration calculating part 34 is according to the relevant information (positional information of the gamma-rays with being detected by gamma-rays test section 33
And dosage information) calculate patient's M bodies in boron concentration distribution.
As shown in Fig. 2 control unit 20 has Rapid Dose Calculation portion 21 and irradiation control unit 22.Control unit 20 and current monitor
7th, neutron beam test section 31 and boron concentration calculating part 34 electrically connect.
Rapid Dose Calculation portion 21 surveys in real time according to the testing result of the current value of the charged particle beam P based on current monitor 7
Fixed (calculating) is irradiated in the charged particle beam P of target 9 dosage.Rapid Dose Calculation portion 21 is by the charged particle beam P determined electric current
Value is according to time successive integration, the real-time dosage for calculating charged particle beam P.
Moreover, testing result of the Rapid Dose Calculation portion 21 according to the neutron beam N based on neutron beam test section 31, the real time measure
The neutron beam N for the opening 12a that (calculating) passes through collimater 12 dosage.In addition, as previously described, because in neutron beam test section 31
Scintillator gamma-rays is also also converted into light in addition to neutron beam N, therefore also sent out based on gamma-ray incident data
Rapid Dose Calculation portion 21 is sent to, but by data of the known discriminating fashion discrimination based on neutron beam N and based on gamma-ray number
According to can only export the data based on neutron beam N.
Also, treatment plan information storage part 40 and display part 41 are electrically connected with control unit 20.Treatment plan information is deposited
The information relevant with patient M treatment plan made by therapy planning device (not shown) is stored with storage portion 40.With treatment
That plans per stipulated time of the treatment comprising patient M in relevant information has with neutron beam N dosage and boron concentration (distribution)
The information (setting value) of pass.
Then, the control action of control unit 20 is illustrated using the flow chart shown in Fig. 4.Control unit 20 reads in storage
In the information (step S100) relevant with treatment plan for the treatment of plan information storage part 40.Also, control unit 20 is read in by agent
Measure the measured value of the dosage for the neutron beam N that calculating part 21 calculates, and the reality of the boron concentration distribution determined by boron concentration mensuration portion 32
Measured value (step S110).
Then, control unit 20 is according to the information relevant with treatment plan, relevant with the neutron beam N of practical measurement dosage
Information and the information relevant with the boron concentration distribution of practical measurement, judge neutron beam irradiation and boron concentration distribution whether according to controlling
Treat plan (step S120).That is, control unit 20 by the setting value of the dosage of the neutron beam N in the information relevant with treatment plan and
The measured value of the neutron beam N calculated by Rapid Dose Calculation portion 21 dosage is contrasted, and judges whether both are consistent or fall providing
In the scope of difference.Such as.The setting value of the dosage of neutron beam N in the information relevant with treatment plan and by Rapid Dose Calculation portion
When the difference of the measured value of the 21 neutron beam N calculated dosage is more than decision threshold, it is judged to not falling within the scope of regulation difference.
In addition, in the measured value of neutron beam N dosage, can use according to the neutron beam N detected by neutron beam test section 31
The neutron beam N calculated dose value, but can also use based on the charged particle beam P's determined by current monitor 7
The dose value for the neutron beam N that current value calculates, both neutron beam N dose value can also be used.
Also, control unit 20 is by the setting value of the boron concentration distribution in the information relevant with treatment plan and by Peng Nong Du Measuring
The measured value for determining the boron concentration of the measure of portion 32 is contrasted, and judges whether both are consistent or fall in the scope of regulation difference.For example,
The setting value of boron concentration distribution in the information relevant with treatment plan and the boron concentration that is determined by boron concentration mensuration portion 32
When the difference of measured value is more than decision threshold, it is judged to not falling within the scope of regulation difference.Further, since boron concentration distribution is two
Distributed data in the regulation space of dimension or three-dimensional, therefore the space is divided into multiple scopes, to each scope divided
The setting value of boron concentration and the measured value of boron concentration contrasted.
The result of contrast, it is being determined as the measured value of the measured value of neutron beam N dosage and boron concentration distribution according to treatment
During plan (or falling in the scope for providing difference from treatment plan), control unit 20 makes neutron beam N irradiation continue to (step
S130).On the other hand, be determined as neutron beam N dosage measured value and boron concentration distribution measured value not according to treatment plan
When (or not falling within out of, treatment plan is regulation difference scope), the dispensing from the boron in boron dispensing portion 17 or adjustment neutron beam are adjusted
N irradiation (step S140).
Following adjustment is carried out in step S140.
(1) when the measured value of boron concentration distribution is not according to treatment plan
When the measured value of boron concentration distribution is more excessive than treatment plan, control unit 20 is with reduction from boron dispensing portion 17 to patient
The mode of the amount of the medicament comprising boron of M supplies controls boron dispensing portion 17.On the contrary, the measured value in boron concentration distribution is counted than treatment
When streaking few, control unit 20 controls boron in a manner of increasing from amount of the boron dispensing portion 17 to the patient M medicaments comprising boron supplied
Dispensing portion 17.
When the measured value of boron concentration distribution is more excessive than treatment plan, control unit 20 can be with so that from neutron beam irradiation portion 4
The mode that irradiation neutron beam N irradiation time is shorter than treatment plan controls accelerator 2 and neutron beam irradiation portion 4.It is on the contrary, dense in boron
When the measured value of degree distribution is more very few than treatment plan, control unit 20 can be with so as to irradiate neutron beam N photograph from neutron beam irradiation portion 4
Penetrate the time mode longer than treatment plan and control accelerator 2 and neutron beam irradiation portion 4.
(2) neutron beam N dosage measured value not according to treatment plan when
When the measured value of neutron beam N dosage is more too high than treatment plan, control unit 20 from neutron beam irradiation portion 4 so as to shine
The mode of the neutron beam N penetrated dosage step-down controls accelerator 2, scanning electro-magnet 8.Make the charged particle projected from accelerator 2
Beam P dosage reduces, and thus enables that the dosage reduction in neutron beam N caused by target 9, and its result can make to irradiate from neutron beam
The dosage for the neutron beam N that portion 4 is irradiated reduces.The charged particle beam P scanned by scanning electro-magnet 8 scan position is adjusted, makes band
Electrochondria beamlet P is radiated at the adjacent peripheral edges of target 9, thus enables that the agent of the neutron beam N after the generation of target 9 by collimater 12
Amount reduces, and its result can reduce the neutron beam N irradiated from neutron beam irradiation portion 4 dosage.On the contrary, in neutron beam N agent
When the measured value of amount is more too low than treatment plan, control unit 20 is so that the neutron beam N irradiated from neutron beam irradiation portion 4 dosage uprises
Mode control accelerator 2, scanning electro-magnet 8.
Control unit 20 judges whether the aggregate-value of the neutron beam N calculated by Rapid Dose Calculation portion 21 dosage reaches to be counted with treatment
Draw the aggregate-value (step S150) of the exposure dose of the neutron beam N in relevant information.When being judged to reaching, control unit 20 stops
Only neutron beam N irradiation and terminate patient M treatment (step S160).When being determined as not up to, step S110 is returned to, after
It is continuous to be treated.
In addition, in step S140, to adjust from boron dispensing portion 17 to the amounts of the patient M medicaments comprising boron supplied
Mode controls boron dispensing portion 17 or to control accelerator in a manner of adjusting the neutron beam N irradiated from neutron beam irradiation portion 4 dosage
2nd, when scanning electro-magnet 8 is more difficult, patient M treatment can be interrupted.Now, control unit 20 controls boron dispensing portion 17 to stop
The medicament of boron only is included to patient M supplies from boron dispensing portion 17, and controls accelerator 2 to stop from neutron beam irradiation portion 4
To patient M irradiation neutron beams N.
Also, control unit 20 can calculate the exposure dose of the neutron beam N in the information for reaching relevant with treatment plan
Remaining irradiation time untill aggregate-value.Control unit 20 judges the accumulative of the neutron beam N calculated by Rapid Dose Calculation portion 21 dosage
Whether value reaches the aggregate-value of the exposure dose of the neutron beam N in the information relevant with treatment plan, when being determined as not up to,
Calculate if in the information for needing how long to reach relevant with treatment plan if continuing neutron beam N irradiation according to treatment plan
The aggregate-value of neutron beam N exposure dose.
As shown in Fig. 2 display part 41 shows the image information 41a relevant with treatment plan, relevant with neutron beam N dosage
Image information 41b and with the concentration dependent image information 41c of boron.In display part 41, show in real time when irradiating neutron beam N
Show the neutron beam N actually irradiated dosage.Also, in display part 41, when irradiating neutron beam N in real time patient M bodies
Boron concentration distribution.
Then the action effect of neutron-capture therapy device 1 is illustrated.
In neutron-capture therapy device 1, due to the concentration of the boron when irradiating neutron beam N in the real time measure patient's M bodies,
Therefore the concentration of the boron in patient's M bodies can be grasped according to measurement result whether according to treatment plan.Thereby, it is possible to realize in boron
Son catches the raising of the reliability of therapy.
The concentration of the patient M boron launched is changed (during irradiation neutron beam N) in the treatment.Caught in conventional boron neutron
Catch in therapy, collection patient M blood, the concentration of the boron in the gathered blood of measure.In this case, due to when measure needs
Between, therefore gather blood and after the elapsed time, it is known that the measurement result of the concentration of boron.Therefore understand in real time inside patient M
Boron concentration to be more difficult., can be real-time when irradiating neutron beam N in the neutron-capture therapy device 1 of present embodiment
Determine the concentration of the boron to be changed with neutron beam N irradiation.
Also, in neutron-capture therapy device 1, gamma-rays test section 33 detects the γ with being released inside patient M
The relevant information of ray, boron concentration calculating part 34 calculate the boron concentration in patient's M bodies from the information relevant with gamma-rays.Thus,
The information relevant with gamma-rays can be detected when irradiating neutron beam, so as to calculate the concentration of the boron in patient's M bodies in real time.
Gamma-rays test section 33 possesses noise remove portion 38, and the noise remove portion 38 is penetrated from the γ with being released from irradiation body
The relevant information of line removes the information relevant with the gamma-rays as noise, therefore is removed by the noise remove portion 38 with turning into
The relevant information of the gamma-rays of noise.Thus, the detection essence of the information relevant with the gamma-rays released inside patient M is improved
Degree, so as to improve the accuracy of detection of the concentration of boron.As a result, the reliability of neutron-capture therapy device 1 can be improved.
Control unit 20 controls boron dispensing portion 17, to have in the concentration of the boron determined with treatment plan relative to being contained in
When the setting value of the concentration of boron in the information of pass is inconsistent or does not fall within the scope of regulation difference, adjust what patient M was launched
The amount of boron.Thus, the concentration of boron when neutron beam N is irradiated in patient M changes with deviateing from treatment plan is larger, also can
The concentration of the enough boron adjusted in a manner of eliminating its variation in patient M.As a result, it can be treated according to treatment plan.
Control unit 20 controls neutron beam irradiation portion 4, so as to the concentration of the boron determined relative to be contained in based on treatment
It is inconsistent or when not falling within the scope of regulation difference to draw the setting value of the concentration of the boron in relevant information, adjusts and is shone from neutron beam
Penetrate the time that neutron beam N is irradiated in portion 4.Thus, although the concentration of the boron in patient M becomes with deviateing from treatment plan is larger
It is dynamic, when can not also adjust the concentration of boron in patient M, it can also be treated according to treatment plan.Even if adjustment is in patient M
The amount of the boron of dispensing, the regular hour is also required to untill the concentration of the boron in patient M is adjusted.Therefore, when closing on treatment
Between at the end of the concentration of boron in patient M when being changed with deviateing from treatment plan is larger, adjusted within treatment time in patient M
Boron concentration to be more difficult.Then, by adjusting irradiation neutron beam N time, the anti-of neutron beam N and the boron in patient M is adjusted
Ying Liang.As a result, even if not adjusting the concentration of the boron in patient M, can also be treated according to treatment plan.
Control unit 20 controls neutron beam irradiation portion 4, so as to the concentration of the boron determined relative to be contained in based on treatment
It is inconsistent or when not falling within the scope of regulation difference to draw the setting value of the concentration of the boron in relevant information, stops shining from neutron beam
Penetrate the neutron beam N in portion 4 irradiation.The amount of the boron to being launched in patient M is being adjusted, is adjusting from neutron beam irradiation portion 4 and irradiates neutron
During beam N time, if the concentration of the boron in patient M can not be tackled from treatment plan during large variation, if continuing to treat,
The treatment according to treatment plan may not then be turned into.By stopping neutron beam N irradiation and interrupting treatment, reality can be prevented
Treat the deterioration changed from treatment plan.
The present invention is not limited to foregoing embodiment, can carry out without departing from the scope of spirit of the present invention such as
Following various modifications.
In above-mentioned embodiment, detect with gamma-rays caused by the reaction of neutron and boron, so as to determine the concentration of boron, but
Being can also be using other assay method come the concentration of the real time measure boron.Can be with the concentration of the real time measure boron, and gather patient M
Blood and determine the concentration of the boron in gathered blood.
Also, gamma-rays test section 33 is not limited to possess gamma-rays detection collimater 35, the 1st detector 36 and
The structure of 2 detectors 37, or the gamma-ray detector of other structures.
Also, control unit 20 can also be the structure for possessing boron concentration calculating part 34.
Claims (6)
1. a kind of neutron-capture therapy device, it irradiates neutron beam to patient, and the boron and neutron for making the patient's body are carried out instead
Should, the neutron-capture therapy device possesses：
Neutron beam irradiation portion, the neutron beam is irradiated to the patient；And
Boron concentration mensuration portion, the boron of patient's body described in the real time measure when irradiating the neutron beam as the neutron beam irradiation portion
Concentration,
The boron concentration mensuration portion has：
Gamma-rays test section, the letter relevant with the gamma-rays released from the patient's body is detected when irradiating the neutron beam
Breath；And
Boron concentration calculating part, according to calculating the information relevant with the gamma-rays detected as the gamma-rays test section
The boron concentration of patient's body.
2. neutron-capture therapy device according to claim 1, wherein,
The gamma-rays test section has noise remove portion, and the noise remove portion is penetrated from the γ with being released from the patient's body
The information relevant with the gamma-rays as noise is removed in the relevant information of line.
3. neutron-capture therapy device according to claim 2, wherein,
The gamma-rays test section possesses：
Gamma-rays detection collimater, formed with the reducing diameter part to diminish from the lateral outlet side internal diameter of entrance and being connected to described
Reducing diameter part and laterally the outlet side internal diameter becomes the through hole of big wide diameter portion from the entrance；
1st detector, arranged opposite with the outlet of the through hole, detection is contained in the of the information relevant with the gamma-rays
1 gamma-rays information；And
2nd detector, is configured at the internal face of the wide diameter portion, and detection is contained in the 2nd of the information relevant with the gamma-rays
Gamma-rays information,
The noise remove portion is removed the 1st gamma-rays information and the 2nd gamma-rays from the 1st gamma-rays information
Information compares and the common information relevant with the gamma-rays, thus removes relevant with as the gamma-rays of the noise
Information.
4. neutron-capture therapy device according to claim 1, is also equipped with：
Treatment plan information storage part, the storage information relevant with treatment plan；
Boron dispensing portion, boron is launched to the patient；And
Control unit, the action in the boron dispensing portion is controlled,
The setting value of the concentration of boron comprising the patient's body in the information relevant with the treatment plan,
Control unit control boron dispensing portion, so as in the concentration of the boron determined relative to the letter relevant with the treatment plan
When the setting value of the concentration of boron included in breath is inconsistent or does not fall within the scope of regulation difference, adjusts and the patient is launched
Boron amount.
5. neutron-capture therapy device according to claim 1, is also equipped with：
Treatment plan information storage part, the storage information relevant with treatment plan；And
Control unit, the action of the neutron beam irradiation portion is controlled,
The setting value of the concentration of boron comprising the patient's body in the information relevant with the treatment plan,
The control unit controls the neutron beam irradiation portion, so as to the concentration of the boron determined relative to the treatment plan
When the setting value of the concentration of boron included in relevant information is inconsistent or does not fall within the scope of regulation difference, adjust from described
Neutron beam irradiation portion irradiates the time of the neutron beam.
6. neutron-capture therapy device according to claim 1, is also equipped with：
Treatment plan information storage part, the storage information relevant with treatment plan；And
Control unit, the action of the neutron beam irradiation portion is controlled,
The setting value of the concentration of boron comprising the patient's body in the information relevant with the treatment plan,
The control unit controls the neutron beam irradiation portion, so as to the concentration of the boron determined relative to the treatment plan
When the setting value of the concentration of boron included in relevant information is inconsistent or does not fall within the scope of regulation difference, stop from described
The irradiation of the neutron beam of neutron beam irradiation portion.
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| Application Number | Priority Date | Filing Date | Title |
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| JP2015043840A JP6565113B2 (en) | 2015-03-05 | 2015-03-05 | Neutron capture therapy device |
| JP2015-043840 | 2015-03-05 |
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| EP3632509B1 (en) * | 2016-01-15 | 2022-08-31 | Neuboron Medtech Ltd. | Neutron capture therapy system |
| WO2018076790A1 (en) * | 2016-10-31 | 2018-05-03 | 南京中硼联康医疗科技有限公司 | Neutron capture therapy system |
| KR101862645B1 (en) * | 2016-10-31 | 2018-06-01 | 가천대학교 산학협력단 | Measuring method of boron concentration for bnct, and treatment planning method with magnetic resonance imaging |
| TWI614042B (en) | 2016-12-02 | 2018-02-11 | 財團法人工業技術研究院 | Neutron beam source generator and filter |
| WO2018168713A1 (en) * | 2017-03-13 | 2018-09-20 | 住友重機械工業株式会社 | Neutron capture therapy system and control device |
| JP6829837B2 (en) * | 2017-03-29 | 2021-02-17 | 住友重機械工業株式会社 | Neutron capture therapy system and gamma ray detector for neutron capture therapy |
| CN109925606B (en) * | 2017-12-15 | 2024-03-22 | 南京中硼联康医疗科技有限公司 | Neutron capture therapy system |
| CN109011221A (en) * | 2018-09-04 | 2018-12-18 | 东莞东阳光高能医疗设备有限公司 | A kind of the neutron capture therapy system and its operating method of dosage guidance |
| DE102018007843B3 (en) * | 2018-10-01 | 2020-01-16 | Forschungszentrum Jülich GmbH | Method for finding a target material and target material for a neutron source |
| WO2020241415A1 (en) * | 2019-05-30 | 2020-12-03 | 住友重機械工業株式会社 | Dose evaluation system |
| JP7430044B2 (en) * | 2019-09-17 | 2024-02-09 | 住友重機械工業株式会社 | radiation therapy equipment |
| CN113877078B (en) * | 2020-07-03 | 2023-06-02 | 中硼(厦门)医疗器械有限公司 | Neutron dose detection device and neutron capture treatment equipment |
| JP7485587B2 (en) * | 2020-11-13 | 2024-05-16 | 株式会社日立製作所 | Particle beam monitoring system, particle beam monitoring method, and particle beam therapy system |
| DE102022132084B4 (en) | 2022-12-02 | 2024-08-22 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Device for porating and loading cells and method therefor |
| DE102022132083B4 (en) | 2022-12-02 | 2024-08-22 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Device for porating and loading cells and method therefor |
| DE102022132082B4 (en) | 2022-12-02 | 2024-08-08 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Process for the preparation of immunocompetent cells genetically transfected and loaded with nanoparticles and/or a cytotoxic substance, as well as immunocompetent cells and medical composition. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3340949B2 (en) * | 1997-11-21 | 2002-11-05 | 関西電力株式会社 | Collimator and gamma ray detector |
| JP2004233168A (en) * | 2003-01-29 | 2004-08-19 | Japan Science & Technology Agency | Neutron shielding plate used for neutron capture therapy, neutron capture therapy performed on mammals other than human and neutron irradiation equipment for the therapy |
| CN201126720Y (en) * | 2007-12-11 | 2008-10-01 | 中国原子能科学研究院 | Gamma spectral measurement collimating device for natrium cold fast reactor |
| FR2930995B1 (en) * | 2008-05-07 | 2010-07-30 | Centre Nat Rech Scient | METHOD AND DEVICE FOR REAL-TIME MEASUREMENT OF LOCAL DOSE DURING TARGET BOMBING WITH HADRONS USING GAMMA PROMPTS |
| EP2600356B1 (en) * | 2010-07-28 | 2017-05-17 | Sumitomo Heavy Industries, Ltd. | Neutron ray irradiation device, and method for control of neutron ray irradiation device |
| JP5490651B2 (en) * | 2010-09-01 | 2014-05-14 | 住友重機械工業株式会社 | Neutron beam irradiation system |
| NL2007596C2 (en) * | 2011-10-14 | 2013-04-16 | Univ Delft Tech | A hadron radiation installation and verification method. |
| JP5630666B2 (en) * | 2012-03-30 | 2014-11-26 | 住友重機械工業株式会社 | Neutron capture therapy collimator and neutron capture therapy device |
| JP5996470B2 (en) * | 2013-03-29 | 2016-09-21 | 住友重機械工業株式会社 | Neutron capture therapy device |
| JP6042269B2 (en) * | 2013-05-22 | 2016-12-14 | 住友重機械工業株式会社 | Neutron capture therapy device and neutron beam measurement method |
-
2015
- 2015-03-05 JP JP2015043840A patent/JP6565113B2/en active Active
-
2016
- 2016-03-02 CN CN201610118023.1A patent/CN105938731B/en active Active
- 2016-03-02 TW TW105106334A patent/TWI589325B/en active
Non-Patent Citations (1)
| Title |
|---|
| Optimization Technique for a Prompt Gamma-ray SPECT Collimator System;MASAYORI ISHIKAWA,et al.;《J.RADIAT.RES》;20011231;第387-400页 * |
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| CN105938731A (en) | 2016-09-14 |
| TWI589325B (en) | 2017-07-01 |
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