CN105935372A - Preparation method of qi-blood Kang oral liquid - Google Patents

Abstract

The invention relates to a preparation method of a qi-blood Kang oral liquid. The preparation method comprises the steps: A, taking fresh pseudo-ginseng or pseudo-ginseng, ginseng, and radix puerariae or pachyrhizua angulatus, mixing, percolating a fluid extract agent and an extract agent through a percolation method, collecting a percolate, and carrying out decompression concentration; and firstly, adjusting the pH value and then concentrating to obtain a spare extract 1, or firstly, concentrating the filtrate and then diluting and adjusting the pH value to 6-14 to obtain a spare filtrate 1; B, decocting radix astragali with water, filtering, concentrating the filtrate, adding ethanol, allowing to stand, and then filtering; and firstly, adjusting the pH value of the filtrate and then concentrating to obtain a spare extract 2, or firstly, concentrating the filtrate and then diluting and adjusting the pH value to 6-14 to obtain a spare filtrate 2; and C, mixing the spare extract 1 and the spare extract 2 with an auxiliary material, or mixing the spare filtrate 1 and the spare filtrate 2 with an auxiliary material; and quantifying, then boiling, adjusting the pH value to 4-6, carrying out microporous filtration treatment to obtain the qi-blood Kang oral liquid. The method is simple and easy to operate, the concentration of retained pharmaceutical effective ingredients is high, and the stability of medicine quality is good.

Description

A kind of preparation method of QIXUEKANG KOUFUYE

Technical field

The present invention relates to the preparation method of a kind of Chinese patent medicine, be specifically related to the preparation method of a kind of QIXUEKANG KOUFUYE.

Quality representated by each parts by weight constant same standard volume in same technical scheme when understanding in the present invention, such as 1 gram, 1 kilogram etc..

Background technology

QIXUEKANG KOUFUYE is recorded in the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation the 13rd, and original name is FUFANG SANQI KOUFUYE.Former National Drug Administration sends the documents " notice (state's pencil notes [2000] No. 169) renamed about national drug standards some Chinese Patent Medicines kind " on April 26th, 2000, FUFANG SANQI KOUFUYE is renamed as QIXUEKANG KOUFUYE, title execution from 1 day June in 2000 after change.QIXUEKANG KOUFUYE has anti-ageing, the body resistance strengthening and constitution consolidating, invigorates vital energy and reinforce the heart, and spleen invigorating consolidates, nourshing Yin and drynsessmoistening prescription, cough-relieving of promoting the production of body fluid；And it is improved the effect of immunity of organisms, leukocyte increasing and hematochrome.Tired weak for god, cardiopalmus of breathing hard, deficiency of YIN Tianjin is few, dry mouth and tougue；It is also used for tumour patient void to decline and radiotherapy, all deficient syndromes of chemotherapy Post operation appearance.

QIXUEKANG KOUFUYE dosage form is mixture, and single dose fill person is also referred to as " oral liquid ".Specifying under four mixture items of " Chinese Pharmacopoeia " version in 2015, outside place states otherwise, mixture should be clarified, it is allowed to has the fugitive precipitation shaken on a small quantity.

Raw material in QIXUEKANG KOUFUYE prescription is after pre-treatment and extracting, after finished dosage form made by addition adjuvant, precipitation and turbidity easily occurs, a large amount of precipitation and turbidity i.e. occurred for the most several days by one month, the clarity making QIXUEKANG KOUFUYE does not reaches drug standard requirement, so that product quality is defective, the active ingredient in medicine runs off in a large number simultaneously, not only affect the industrialized production of medicine but also have impact on the therapeutic effect of medicine, it is difficult to meet the demand of doctor and patient.

Summary of the invention

The present invention is directed to QIXUEKANG KOUFUYE of the prior art and easily occur that precipitation causes clarity undesirable, affect drug quality and the problem such as industrialized production, there is provided a kind of simple and easy to do, retain active ingredient concentration high, the preparation method of the QIXUEKANG KOUFUYE of drug quality good stability.

The above-mentioned purpose of the present invention is achieved through the following technical solutions: the preparation method of a kind of QIXUEKANG KOUFUYE, and described preparation method comprises the steps:

Take fresh Radix Notoginseng or Radix Notoginseng, Radix Ginseng, Radix Puerariae or Pachyrhizua angulatus mixing, according to fluid extract and the percolation ethanol as solvent with concentration as 45-75% under extractum item, impregnate 24 hours, slowly percolation, collect percolate medical material amount 6-20 times, reclaiming ethanol, being evaporated to relative density at 50-60 DEG C is the extracting solution of 1.02-1.06；By extracting solution by first adjust pH value to 6-14, reconcentration obtains standby extractum 1, or is first stood by extracting solution, filters, then filtrate is condensed into extractum then by extractum dilute after adjust pH value to 6-14, obtain standby filtrate 1；

Taking the Radix Astragali, soak by water for several times, filters, and it is the clear paste of 1.10-1.15 that filtrate is concentrated into relative density at 50-60 DEG C, adds 80-95% ethanol, makes concentration of alcohol reach 45-75%, stands 48 hours, filters, filtrate recycling ethanol；By first filtrate being regulated pH value to 6-14, then filtrate is concentrated to give standby extractum 2, or by adjusting pH value to 6-14 after filtrate is first condensed into extractum being diluted by extractum again, obtains standby filtrate 2；

Standby extractum 1 and standby extractum 2 are mixed with the adjuvant of QIXUEKANG KOUFUYE, or standby filtrate 1 and standby filtrate 2 are mixed with the adjuvant of QIXUEKANG KOUFUYE；Adding in mixed material after purified water makes ormal weight and boil, regulation pH value is to 4.0-6.0, and last microporous filter processes and prepares QIXUEKANG KOUFUYE.

In the preparation method of above-mentioned QIXUEKANG KOUFUYE, use K₂CO₃、KHCO₃, NaOH, KOH, lime water [Ca (OH)₂]、Na₂CO₃、NaHCO₃, strong aqua ammonia, Ba (OH)₂In the mixture regulation pH value of any ratio of one or more to 6-14.

In the preparation method of above-mentioned QIXUEKANG KOUFUYE, QIXUEKANG KOUFUYE includes main material and adjuvant, main material includes fresh Radix Notoginseng or Radix Notoginseng, the Radix Astragali, Radix Ginseng, Radix Puerariae or Pachyrhizua angulatus, main material consists of: fresh Radix Notoginseng 17-1700 part (or Radix Notoginseng 4-450g), Radix Astragali 10-1000 part, Radix Ginseng 2-200 part, Radix Puerariae or Pachyrhizua angulatus 1-140 part.

As preferably, in described QIXUEKANG KOUFUYE, main material consists of: fresh Radix Notoginseng 34-850 part (or Radix Notoginseng 9-225g), Radix Astragali 20-500 part, Radix Ginseng 4-100 part, Radix Puerariae or Pachyrhizua angulatus 3-70 part.

Further preferably, in described QIXUEKANG KOUFUYE, main material consists of: fresh Radix Notoginseng 85-340 part (or Radix Notoginseng 22-90g), Radix Astragali 50-200 part, Radix Ginseng 10-40 part, Radix Puerariae or Pachyrhizua angulatus 7-28 part.

Further preferred, in described QIXUEKANG KOUFUYE, main material consists of: fresh Radix Notoginseng 170 parts (or Radix Notoginseng 45g), the Radix Astragali 100 parts, Radix Ginseng 20 parts, Radix Puerariae or Pachyrhizua angulatus 14 parts.

As preferably, it is 50-500 part that described adjuvant amounts to (in terms of parts by weight), including correctives, preservative.

Further preferably, described correctives includes the mixture of one or more any ratios of Mel, simple syrup, sucrose, aspartame, stevioside, saccharin sodium, acesulfame potassium (acesulfame potassium), cyclamate, protein sugar, glucose.

Further preferred, described correctives is a kind of or mixture of both any ratios in Mel, sucrose.

Further preferred, described correctives be Mel, both sucrose arbitrarily than mixture.

The described fresh Radix Notoginseng in QIXUEKANG KOUFUYE main material is fresh and the rhizome of panax araliaceae plant Parmx notoginseng (Burk.) F.H.Chen；Radix Notoginseng is dry root and the rhizome of panax araliaceae plant Parmx notoginseng (Burk.) F.H.Chen, and processed product cooked Radix Notoginseng；The Radix Astragali is leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or the dry root of Radix Astragali Astragalus membranaceus (Fisch.) Bge., and processed product Radix Astragali (processed with Mel)；Radix Ginseng is dry root and the rhizome of Araliaceae Radix Ginseng Panax ginseng C.A.Mey., and processed product Radix Ginseng Rubra；Pachyrhizua angulatus is the dry root of leguminous plant Radix Puerariae rattan Puerariathomsonii Benth., and processed product；Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi, and processed product.

In the preparation method of above-mentioned QIXUEKANG KOUFUYE, it is 0.1-10 μm that microporous filter processes the aperture of film used.

As preferably, it is 0.15-8 μm that microporous filter processes the aperture of film used.

Further preferably, microporous filter processes the aperture of film used is 0.2-5 μm.

Further preferred, it is 0.4-3 μm that microporous filter processes the aperture of film used.

As preferably, the preparation method of QIXUEKANG KOUFUYE comprises the steps:

Take fresh Radix Notoginseng or Radix Notoginseng, Radix Ginseng, Radix Puerariae or Pachyrhizua angulatus mixing, according to fluid extract and the percolation ethanol as solvent with concentration as 45-75% under extractum item, impregnate 24 hours, slowly percolation, collect percolate medical material amount 6-20 times, reclaim ethanol, being evaporated to relative density at 50-60 DEG C is 1.02-1.06, adjusts pH value to 6-14, stands, filters, it is the extractum of 1.15-1.20 that filtrate is concentrated into relative density at 50-60 DEG C, standby extractum 1；

Take the Radix Astragali, use soak by water respectively 1-3 time, each 1-3 hour, filtering, it is the clear paste of 1.10-1.15 that filtrate is concentrated into relative density at 50-60 DEG C, adds 80-95% ethanol, concentration of alcohol is made to reach 45-75%, stand 48 hours, filter, filtrate recycling ethanol, regulation pH value is to 6-14, standing, filter, it is the extractum of 1.20-1.25 that filtrate is concentrated into relative density at 50-60 DEG C, standby extractum 2；

Standby extractum 1, standby extractum 2 being mixed with the adjuvant of QIXUEKANG KOUFUYE, add after purified water makes ormal weight and boil, regulation pH value to 4.0-6.0, last microporous filter processes and prepares final QIXUEKANG KOUFUYE.

As preferably, the preparation method of above-mentioned QIXUEKANG KOUFUYE comprises the steps:

Take fresh Radix Notoginseng or Radix Notoginseng, Radix Ginseng, Radix Puerariae or Pachyrhizua angulatus mixing, according to fluid extract and the percolation ethanol as solvent with concentration as 45-75% under extractum item, impregnate 24 hours, slowly percolation, collect percolate medical material amount 6-20 times, reclaim ethanol, being evaporated to relative density at 50-60 DEG C is 1.02-1.06, stand, filter, filtrate is concentrated into the extractum 3 that relative density at 50-60 DEG C is 1.15-1.20, after being diluted by standby extractum, regulation pH value is to 6-14, stands, filters to obtain standby filtrate 1；

Take the Radix Astragali, use soak by water respectively 1-3 time, each 1-3 hour, filter, it is the clear paste of 1.10-1.15 that filtrate is concentrated into relative density at 50-60 DEG C, adds 80-95% ethanol, makes concentration of alcohol reach 45-75% ethanol, stand 48 hours, filtering, filtrate recycling ethanol, filtrate is concentrated into the extractum 4 that relative density at 50-60 DEG C is 1.20-1.25, after the dilution of standby extractum 4, regulation pH value is to 6-14, stands, filters to obtain standby filtrate 2；

Standby filtrate 1, standby filtrate 2 being mixed with the adjuvant of QIXUEKANG KOUFUYE, add after purified water makes ormal weight and boil, regulation pH value to 4.0-6.0, last microporous filter processes and prepares final QIXUEKANG KOUFUYE.

QIXUEKANG KOUFUYE preparation technology compares with tradition, the preparation method of QIXUEKANG KOUFUYE of the present invention adds pH value control and microporous filter technique, both solved medicine and precipitation had easily occurred, the problem of clarity difference, reservation active ingredient concentration can be made again high, and it is more suitable for industrialized production, make drug quality stable.After testing, the Ginsenoside Rg1 in QIXUEKANG KOUFUYE of the present invention, ginsenoside Rg1, ginsenoside Rb1's content are greatly improved, and can improve 50%-120%, and the QIXUEKANG KOUFUYE prepared can keep the clear and bright fugitive precipitation only occurring and shaking on a small quantity in 2 years.

Detailed description of the invention

In order to make technical problem solved by the invention, technical scheme and beneficial effect clearer, below in conjunction with specific embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.

Embodiment 1

Take fresh Radix Notoginseng 1000K part, Radix Astragali 800K part, Radix Ginseng 3k part, Radix Puerariae 2K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng and Radix Puerariae and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 50% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 10050K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), pH value is regulated to 13 with the NaOH aqueous solution of 1mol/L, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with the soak by water 1 time of 8 times amount, decoct 2 hours, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 80% ethanol, makes concentration of alcohol reach 55% ethanol, stand 48 hours, filter, filtrate recycling ethanol, regulate pH value to 13 with the NaOH of 1mol/L, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2.

Take standby extractum 1, standby extractum 2, sucrose 40K part, add a certain amount of hot water, after melting, pour material-compound tank mixing into；Take benzoic acid 1.5K part, after adding appropriate 95% ethanol dissolving, after hot water dissolves, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 40 minutes；Regulate liquid pH value about 5.5 in material-compound tank after cooling, by 5 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 2

Take fresh Radix Notoginseng 30K part, Radix Astragali 15K part, Radix Ginseng 120K part, Pachyrhizua angulatus 120K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng and Pachyrhizua angulatus and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 70% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 5700K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum 1 with after 3 times amount purified water dilutions, with NaOH:KOH (1:1) aqueous solution regulation pH value to 10, stand more than 48 hours, filter, standby filtrate 1；

Take the Radix Astragali respectively with 6 times, the soak by water of 5 times amount 2 times, 3 hours for the first time, for the second time 1 hour, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 95% ethanol, concentration of alcohol is made to reach 70% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 2 with after 3 times amount purified water dilutions, with NaOH:KOH (1:1) aqueous solution regulation pH value to 10, stand more than 48 hours, filter, standby filtrate 2；

By 2-in-1 also to standby filtrate 1, standby filtrate, add Mel 300K part of filtering and impurity removing, pour material-compound tank mixing into；Take sodium benzoate 2K part, after adding appropriate 90% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 35 minutes；Regulate liquid pH value about 6 in material-compound tank after cooling, by 3 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 3

Take fresh Radix Notoginseng 600K part, Radix Astragali 400K part, Radix Ginseng 8K part, Radix Puerariae 6K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng and Radix Puerariae and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 75% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 15200K part, reclaim ethanol, be evaporated to relative density 1.02～1.06 (50～60 DEG C), with saturated limewater [Ca (OH)₂] regulation pH value to 8, stands more than 48 hours, filtration, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 4 times, 4 times, the soak by water of 5 times amount 3 times, decoct 3,2,2 hours according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 90% ethanol, makes concentration of alcohol reach 65% ethanol, stand 48 hours, filtering, filtrate recycling ethanol, with saturated limewater [Ca (OH)₂] regulation pH value to 6.5, stands more than 48 hours, filters, filtrate is concentrated into relative density be 1.20～1.25 extractum of (50～60 DEG C of heat surveys), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take acesulfame potassium (acesulfame potassium) 70K part, add addition material-compound tank after appropriate purified water is dissolved；Take methyl parahydroxybenzoate (methyl hydroxybenzoate) 1K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 45 minutes；Regulate liquid pH value about 4.5 in material-compound tank after cooling, by 1 μm filtering with microporous membrane, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 4

Take fresh Radix Notoginseng 60K part, Radix Astragali 40K part, Radix Ginseng Rubra 80K part, Pachyrhizua angulatus 60K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng Rubra and Pachyrhizua angulatus and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 45% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 4800K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum with 7 with after 2 times amount purified water dilutions, use Na₂CO₃Aqueous solution regulation pH value, to 8, stands more than 48 hours, filters, standby filtrate 1；

Take the Radix Astragali respectively with 6 times, 4 times, the soak by water of 3 times amount 3 times, decoct 2 hours, 2 hours, 1 hour every time, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 85% ethanol, concentration of alcohol is made to reach 60% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 2 with after 1 times amount purified water dilution, use Na₂CO₃Aqueous solution regulation pH value, to 8, stands more than 48 hours, filters, standby filtrate 2；

Standby filtrate 1, standby filtrate are 2-in-1 also, add with appropriate water-soluble saccharin sodium-glucose mixture (arbitrarily than), pour material-compound tank into and mix；Take ethylparaben (ethyl hydroxybenzoate) 0.5K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 35 minutes；Regulate liquid pH value about 4 in material-compound tank after cooling, by 0.5 μm filtering with microporous membrane, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 5

Take fresh Radix Notoginseng 300K part, Radix Astragali (processed with Mel) 180K part, Radix Ginseng 15K part, Radix Puerariae 12K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng and Radix Puerariae and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 60% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 9200K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), with strong aqua ammonia regulation pH value to 6, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take Radix Astragali (processed with Mel) respectively with 3 times, the soak by water of 3 times amount 2 times, decoct 1 hour, 1 hour according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 95% ethanol, makes concentration of alcohol reach 60% ethanol, stand 48 hours, filter, filtrate recycling ethanol, with strong aqua ammonia regulation pH value to 6, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take simple syrup, aspartame, saccharin sodium each 20K part, add addition material-compound tank after appropriate purified water is dissolved；Take propyl p-hydroxybenzoate (propylparaben) 0.8K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 33 minutes；Regulate liquid pH value about 5 in material-compound tank after cooling, by 0.2 μm filtering with microporous membrane, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 6

Take fresh Radix Notoginseng 120K part, Radix Astragali 80K part, Radix Ginseng 30K part, Pachyrhizua angulatus 25K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng Rubra and Pachyrhizua angulatus and is respectively crushed into coarse powder, three is mixed and with 68% ethanol as solvent, impregnates 24 hours, slowly percolation according to percolation under fluid extract and extractum item, collect percolate about 3570K part, reclaim ethanol, be evaporated to relative density 1.02～1.06 (50～60 DEG C), stand more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum, and 1；

Take the Radix Astragali respectively with 7 times, the soak by water of 5 times amount 2 times, decoct 3 hours, 1 hour every time, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 88% ethanol, concentration of alcohol is made to reach 58% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；

By standby extractum with 1 with after 1 times amount purified water dilution, with Ba (OH)₂Aqueous solution regulation pH value, to 9.5, stands more than 48 hours, filters, standby filtrate 1；Standby extractum 2 is with after 2 times amount purified water dilutions, with Ba (OH)₂Aqueous solution regulation pH value, to 9.5, stands more than 48 hours, filters, standby filtrate 2；

Standby filtrate 1, standby filtrate are 2-in-1 also, add with appropriate water-soluble stevioside 50K part, pour material-compound tank into and mix；Take butyl p-hydroxybenzoate (butoben) 0.6K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 38 minutes；Regulate liquid pH value about 5 in material-compound tank after cooling, by 0.8 μm filtering with microporous membrane, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 7

Take fresh Radix Notoginseng 200K part, Radix Astragali 150K part, Radix Ginseng Rubra 15k part, Radix Puerariae 10K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng Rubra and Radix Puerariae and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 68% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 6000K part, reclaim ethanol, be evaporated to relative density 1.02～1.06 (50～60 DEG C), use NaHCO₃Aqueous solution regulation pH value, to 7, stands more than 48 hours, filters, and filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 4 times, 2 times, the soak by water of 1 times amount 3 times, decoct 3 hours, 2 hours, 1 hour according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 88% ethanol, makes concentration of alcohol reach 66% ethanol, stand 48 hours, filter, filtrate recycling ethanol, use NaHCO₃Aqueous solution regulation pH value, to 7, stands more than 48 hours, filters, and filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take cyclamate 20K part, protein sugar 30K part, add addition material-compound tank after appropriate purified water is dissolved；Take butyl p-hydroxybenzoate (butoben) 0.6K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 35 minutes；Regulate liquid pH value about 5.5 in material-compound tank after cooling, by 0.8 μm filtering with microporous membrane, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 8

Take Radix Notoginseng (fresh) 150K part, Radix Astragali (processed with Mel) 90K part, Radix Ginseng 25k part, Pachyrhizua angulatus 20K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng and Pachyrhizua angulatus and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 48% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 5700K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum with 1 with after 1.5 times amount purified water dilutions, with NaOH, Na₂CO₃Mixed aqueous solution regulation pH value, to 11, stands more than 48 hours, filters, standby filtrate 1；

Take Radix Astragali (processed with Mel) respectively with 6 times, the soak by water of 3 times amount 2 times, decoct 2 hours, 2 hours every time, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 86% ethanol, concentration of alcohol is made to reach 72% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 2 with after 2.5 times amount purified water dilutions, with NaOH, Na₂CO₃Mixed aqueous solution regulation pH value, to 11, stands more than 48 hours, filters, standby filtrate 2；

By 2-in-1 also to standby filtrate 1, standby filtrate, add with appropriate water-soluble sucrose 80K part, aspartame 3K part, pour material-compound tank into and mix；Take sorbic acid 1.5K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 38 minutes；Regulate liquid pH value about 4 in material-compound tank after cooling, by 1.5 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 9

Take Radix Notoginseng (fresh) 170K part, Radix Astragali 100K part, Radix Ginseng 20K part, Radix Puerariae 14K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng and Radix Puerariae and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 60% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 3040K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), with NaOH aqueous solution regulation pH value to 10, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 6 times, 6 times, the soak by water of 6 times amount 3 times, according to this decoct 2.5 hours, 2.5 hours, 2.5 hours, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), add 95% ethanol, concentration of alcohol is made to reach 60% ethanol, stand 48 hours, filtering, filtrate recycling ethanol, NaOH aqueous solution regulation pH value is to 10, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take Mel 233K part, sucrose 20K part, add after appropriate purified water dissolves filtration and add material-compound tank；Take sodium benzoate 1.5K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 5 in material-compound tank after cooling, by 1.5 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 10

Take Radix Notoginseng (fresh) 170K part, Radix Astragali 100K part, Radix Ginseng 20K part, Pachyrhizua angulatus 14K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng and Pachyrhizua angulatus and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 60% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 3040K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum 1 with after 1 times amount purified water dilution, with NaOH aqueous solution regulation pH value to 10, filter, standby filtrate 1；

Take the Radix Astragali respectively with 6 times, 6 times, the soak by water of 6 times amount 3 times, decoct 2.5 hours, 2.5 hours, 2.5 hours every time, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 95% ethanol, concentration of alcohol is made to reach 60% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 20 with after 1 times amount purified water dilution, with NaOH aqueous solution regulation pH value to 10, stand more than 48 hours, filter, standby filtrate 2；

Standby filtrate 1, standby filtrate are 2-in-1 also, add with appropriate water-soluble Mel 233K part, sucrose 20K part, pour material-compound tank into and mix；Take sodium benzoate 1.5K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 4.5 in material-compound tank after cooling, by 1.5 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 11

Take Radix Notoginseng 400K part, Radix Astragali 800K part, Radix Ginseng 3k part, Radix Puerariae 2K part.Radix Notoginseng, Radix Ginseng and Radix Puerariae are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 65% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 10000K part, reclaim ethanol, be evaporated to relative density 1.02～1.06 (50～60 DEG C), with NaOH, Ba (OH)₂Mixed aqueous solution regulation pH value, to 12, stands more than 48 hours, filters, and filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 4 times, the soak by water of 4 times amount 2 times, decoct 2 hours, 1 hour according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 90% ethanol, makes concentration of alcohol reach 56% ethanol, stand 48 hours, filtering, filtrate recycling ethanol, with NaOH, Ba (OH)₂Mixed aqueous solution regulation pH value, to 10.5, stands more than 48 hours, filters, and filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take sucrose 50K part, cyclamate 20K part, add addition material-compound tank after appropriate purified water is dissolved；Take methyl parahydroxybenzoate (methyl hydroxybenzoate), propyl p-hydroxybenzoate (propylparaben) each 0.3K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 30 minutes；Regulate liquid pH value about 5.2 in material-compound tank after cooling, by 1.8 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 12

Take Radix Notoginseng 5K part, Radix Astragali 15K part, Radix Ginseng 120k part, Pachyrhizua angulatus 120K part.Radix Notoginseng, Radix Ginseng and Pachyrhizua angulatus are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 55% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 3000K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum 1 with after 2 times amount purified water dilutions, with NaOH, dense ammonia mixed aqueous solution regulation pH value to 10, stand more than 48 hours, filter, standby filtrate 1；

Take the Radix Astragali respectively with 8 times, the soak by water of 4 times amount 2 times, decoct 2 hours, 2 hours every time, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 90% ethanol, concentration of alcohol is made to reach 63% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 2 with after 2 times amount purified water dilutions, with NaOH, dense ammonia mixed aqueous solution regulation pH value to 10, stand more than 48 hours, filter, standby filtrate 2；

By 2-in-1 also to standby filtrate 1, standby filtrate, add with appropriate water-soluble Mel 80K part, saccharin sodium 30K part, pour material-compound tank into and mix；Take ethylparaben (ethyl hydroxybenzoate), butyl p-hydroxybenzoate (butoben) each 0.2K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 31 minutes；Regulate liquid pH value about 5.6 in material-compound tank after cooling, by 1 μm filtering with microporous membrane, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 13

Take Radix Notoginseng 150K part, Radix Astragali 400K part, Radix Ginseng 8K part, Radix Puerariae 6K part.Radix Notoginseng, Radix Ginseng and Radix Puerariae are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 55% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 5000K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), with KOH, dense ammonia mixed aqueous solution regulation pH value to 11, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 5 times, the soak by water of 4 times amount 2 times, decoct 1 hour, 1 hour according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), add 92% ethanol, concentration of alcohol is made to reach 65% ethanol, stand 48 hours, filter, filtrate recycling ethanol, with KOH, dense ammonia mixed aqueous solution regulation pH value to 11, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take Mel 100K part, acesulfame potassium (acesulfame potassium) 10K part, add addition material-compound tank after appropriate purified water is dissolved；Take ethylparaben (ethyl hydroxybenzoate) 0.2K part, propyl p-hydroxybenzoate (propylparaben) 0.3K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 33 minutes；Regulate liquid pH value about 4.8 in material-compound tank after cooling, by 2 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 14

Take Radix Notoginseng 20K part, Radix Astragali 40K part, Radix Ginseng Rubra 80K part, Pachyrhizua angulatus 60K part.Radix Notoginseng, Radix Ginseng and Pachyrhizua angulatus are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 65% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 3000K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum 1 with after 1.5 times amount purified water dilutions, with KOH, lime water [Ca (OH)₂] mixed aqueous solution regulation pH value to 10.5, stands more than 48 hours, filtration, standby filtrate 1；

Take the Radix Astragali respectively with 5 times, the soak by water of 5 times amount 2 times, decoct 2 hours, 1 hour every time, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 90% ethanol, concentration of alcohol is made to reach 58% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 2 with after 1.5 times amount purified water dilutions, with KOH, lime water [Ca (OH)₂] mixed aqueous solution regulation pH value to 10.5, stands more than 48 hours, filtration, standby filtrate 2；

Standby filtrate 1, standby filtrate are 2-in-1 also, add with appropriate water-soluble Mel 80K part, cyclamate 20K part, pour material-compound tank into and mix；Take propyl p-hydroxybenzoate (propylparaben) 0.2K part, butyl p-hydroxybenzoate (butoben) 0.5K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 4.5 in material-compound tank after cooling, by 3 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 15

Take Radix Notoginseng 80K part, Radix Astragali (processed with Mel) 180K part, Radix Ginseng 15K part, Radix Puerariae 12K part.Radix Notoginseng, Radix Ginseng and Radix Puerariae are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 70% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 3000K part, reclaim ethanol, be evaporated to relative density 1.02～1.06 (50～60 DEG C), with NaOH, lime water [Ca (OH)₂] mixed aqueous solution regulation pH value to 12.5, stands more than 48 hours, filtration, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take Radix Astragali (processed with Mel) respectively with 4 times, the soak by water of 2 times amount 2 times, decoct 2 hours, 1 hour according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 95% ethanol, makes concentration of alcohol reach 70% ethanol, stand 48 hours, filtering, filtrate recycling ethanol, with NaOH, lime water [Ca (OH)₂] mixed aqueous solution regulation pH value to 12.5, stands more than 48 hours, filters, filtrate is concentrated into relative density be 1.20～1.25 extractum of (50～60 DEG C of heat surveys), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take Mel 50K part, aspartame 30K part, add addition material-compound tank after appropriate purified water is dissolved；Take ethylparaben (ethyl hydroxybenzoate) 0.2K part, propyl p-hydroxybenzoate (propylparaben) 0.6K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 6 in material-compound tank after cooling, by 2.6 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 16

Take Radix Notoginseng 30K part, Radix Astragali 80K part, Radix Ginseng 30K part, Pachyrhizua angulatus 25K part.Radix Notoginseng, Radix Ginseng and Pachyrhizua angulatus are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 63% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 3570K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum 1 with after 2 times amount purified water dilutions, with strong aqua ammonia, Ba (OH)₂Mixed aqueous solution regulation pH value, to 10, stands more than 48 hours, filters, standby filtrate 1；

Take the Radix Astragali respectively with 6 times, the soak by water of 3 times amount 2 times, decoct 2 hours, 1 hour every time, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 90% ethanol, concentration of alcohol is made to reach 66% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 2 with after 2 times amount purified water dilutions, with strong aqua ammonia, Ba (OH)₂Mixed aqueous solution regulation pH value, to 10, stands more than 48 hours, filters, standby filtrate 2；

Standby filtrate 1, standby filtrate are 2-in-1 also, add with appropriate water-soluble Mel 60K part, stevioside 5K part, pour material-compound tank into and mix；Take methyl parahydroxybenzoate (methyl hydroxybenzoate), ethylparaben (ethyl hydroxybenzoate), butyl p-hydroxybenzoate (butoben) each 0.2K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 5.5 in material-compound tank after cooling, by 3.5 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 17

Take Radix Notoginseng 50K part, Radix Astragali 150K part, Radix Ginseng Rubra 15k part, Radix Puerariae 10K part.Radix Notoginseng, Radix Ginseng and Radix Puerariae are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 50% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 2250K part, reclaim ethanol, be evaporated to relative density 1.02～1.06 (50～60 DEG C), with NaOH, K₂CO₃、KOH、Na₂CO₃Mixed aqueous solution regulation pH value, to 11, stands more than 48 hours, filters, and filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 4 times, the soak by water of 2 times amount 2 times, decoct 1 hour, 1 hour according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 90% ethanol, makes concentration of alcohol reach 65% ethanol, stand 48 hours, filtering, filtrate recycling ethanol, with NaOH, K₂CO₃、KOH、Na₂CO₃Mixed aqueous solution regulation pH value, to 11, stands more than 48 hours, filters, and filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take Mel 80K part, aspartame 10K part, saccharin sodium 5K part, add addition material-compound tank after appropriate purified water is dissolved；Take methyl parahydroxybenzoate (methyl hydroxybenzoate), ethylparaben (ethyl hydroxybenzoate), propyl p-hydroxybenzoate (propylparaben), butyl p-hydroxybenzoate (butoben) each 0.2K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 5.3 in material-compound tank after cooling, by 1.5 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 18

Take Radix Notoginseng 40K part, Radix Astragali (processed with Mel) 90K part, Radix Ginseng 25k part, Pachyrhizua angulatus 20K part.Radix Notoginseng, Radix Ginseng and Pachyrhizua angulatus are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 62% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 2000K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum with 1 with after 1 times amount purified water dilution, with NaOH, K₂CO₃、KOH、Na₂CO₃, dense ammonia mixed aqueous solution regulation pH value to 12, stands more than 48 hours, filtration, standby filtrate 1；

Take Radix Astragali (processed with Mel) respectively with 6 times, the soak by water of 2 times amount 2 times, decoct 3 hours, 1 hour every time, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 90% ethanol, concentration of alcohol is made to reach 55% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 2 with after 1 times amount purified water dilution, with NaOH, K₂CO₃、KOH、Na₂CO₃, dense ammonia mixed aqueous solution regulation pH value to 12, stands more than 48 hours, filtration, standby filtrate 2；

By 2-in-1 also to standby filtrate 1, standby filtrate, add with appropriate water-soluble Mel, sucrose, aspartame, stevioside, saccharin sodium, acesulfame potassium (acesulfame potassium) each 12K part, pour material-compound tank into and mix；Take butyl p-hydroxybenzoate (butoben) 0.2K part, potassium sorbate 0.15K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 4 in material-compound tank after cooling, by 3.6 μm filtering with microporous membranes, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 19

Take Radix Notoginseng 45K part, Radix Astragali 100K part, Radix Ginseng 20K part, Radix Puerariae 14K part.Radix Notoginseng, Radix Ginseng and Radix Puerariae are respectively crushed into coarse powder, three is mixed and with 60% ethanol as solvent, impregnates 24 hours, slowly percolation according to percolation under fluid extract and extractum item, collect percolate about 1790K part, reclaim ethanol, be evaporated to relative density 1.02～1.06 (50～60 DEG C), with NaOH aqueous solution regulation pH value to 10, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 6 times, 6 times, the soak by water of 6 times amount 3 times, decoct 2.5 hours, 2.5 hours, 2.5 hours according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), add 95% ethanol, concentration of alcohol is made to reach 60% ethanol, stand 48 hours, filter, filtrate recycling ethanol, with NaOH aqueous solution regulation pH value to 10, stand more than 48 hours, filtering, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take Mel 233K part, sucrose 20K part, add addition material-compound tank after appropriate purified water is dissolved；Take sodium benzoate 1.5K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 5 in material-compound tank after cooling, by 0.65 μm filtering with microporous membrane, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Embodiment 20

Take Radix Notoginseng 45K part, Radix Astragali 100K part, Radix Ginseng 20K part, Pachyrhizua angulatus 14K part.Radix Notoginseng, Radix Ginseng and Pachyrhizua angulatus are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 60% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 1790K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), stands more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；By standby extractum with 1 with after 1 times amount purified water dilution, with NaOH aqueous solution regulation pH value to 10, stand more than 48 hours, filter, standby filtrate 1；

Take the Radix Astragali respectively with 6 times, 6 times, the soak by water of 6 times amount 3 times, decoct 2.5 hours, 2.5 hours, 2.5 hours according to this, filtering, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), adds 95% ethanol, concentration of alcohol is made to reach 60% ethanol, stand 48 hours, filter, filtrate recycling ethanol, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；By standby extractum 2 with after 1 times amount purified water dilution, with NaOH aqueous solution regulation pH value to 10, stand more than 48 hours, filter, standby filtrate 2；

By 2-in-1 also to standby filtrate 1, standby filtrate, add with appropriate water-soluble stevioside, pour material-compound tank into and mix；Take Mel 233K part, sucrose 20K part, add addition material-compound tank after appropriate purified water is dissolved；Take sodium benzoate 1.5K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 5 in material-compound tank after cooling, by 0.65 μm filtering with microporous membrane, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Comparative example 1

Take Radix Notoginseng (fresh) 170K part, Radix Astragali 100K part, Radix Ginseng 20K part, Radix Puerariae 14K part.Fresh pseudo-ginseng root slices is ground into coarse powder, Radix Ginseng and Radix Puerariae and is respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 60% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 3040K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), does not process and directly stand more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 6 times, 6 times, the soak by water of 6 times amount 3 times, decoct according to this 2.5 hours, 2.5 hours, 2.5 hours, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), add 95% ethanol, make concentration of alcohol reach 60% ethanol, stand 48 hours, filter, filtrate recycling ethanol, does not process and directly stands more than 48 hours, filters, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2.

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take Mel 233K part, sucrose 20K part, add after appropriate purified water dissolves filtration and add material-compound tank；Take sodium benzoate 1.5K part, after adding ethanol in proper amount dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 5 in material-compound tank after cooling, commonly filter, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Comparative example 2

Take Radix Notoginseng 45K part, Radix Astragali 100K part, Radix Ginseng 20K part, Radix Puerariae 14K part.Radix Notoginseng, Radix Ginseng and Radix Puerariae are respectively crushed into coarse powder, three is mixed according to percolation under fluid extract and extractum item with 60% ethanol as solvent, impregnate 24 hours, slowly percolation, collect percolate about 1790K part, reclaim ethanol, it is evaporated to relative density 1.02～1.06 (50～60 DEG C), does not process and directly stand more than 48 hours, filter, filtrate is concentrated into the extractum that relative density is 1.15～1.20 (50～60 DEG C), standby extractum 1；

Take the Radix Astragali respectively with 6 times, 6 times, the soak by water of 6 times amount 3 times, decoct 2.5 hours, 2.5 hours, 2.5 hours according to this, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (50～60 DEG C), add 95% ethanol, make concentration of alcohol reach 60% ethanol, stand 48 hours, filter, filtrate recycling ethanol, does not process and directly stands more than 48 hours, filters, filtrate is concentrated into the extractum that relative density is 1.20～1.25 (50～60 DEG C of heat are surveyed), standby extractum 2；

Standby extractum 1, standby extractum 2 are separately added into a certain amount of hot water, after melting, pour material-compound tank mixing into；Take Mel 233K part, sucrose 20K part, add addition material-compound tank after appropriate purified water is dissolved；Take sodium benzoate 1.5K part, after adding appropriate 95% ethanol dissolving, pour material-compound tank into；Continuously add purified water to 1000K part volume, after stirring, boil 32 minutes；Regulate liquid pH value about 5 in material-compound tank after cooling, commonly filter, fill, sterilization, packaging, obtain QIXUEKANG KOUFUYE.

Performance test:

1, arasaponin R1, ginsenoside Rg1, ginsenoside Rb1's Simultaneous Determination: according to high effective liquid chromatography for measuring.

Chromatographic condition and system suitability: be bonded glue as filler with octadecyl silicon；With acetonitrile as mobile phase A, with water as Mobile phase B, carry out gradient elution by table 1 regulation；Detection wavelength is 203nm.Number of theoretical plate is calculated by ginsenoside Rg1 should be not less than 4000.

Table 1:

Time (minute)	Mobile phase A (%)	Mobile phase B (%)
			0～12	19	81
12～75	19→34	81→66

The preparation of reference substance solution: take arasaponin R1 reference substance, ginsenoside Rg1's reference substance and ginsenoside Rb1's reference substance appropriate, accurately weighed, add methanol and make every 1ml containing arasaponin R1 0.1mg, ginsenoside Rg1 0.4mg, the mixed solution of ginsenoside Rb1 0.4mg, to obtain final product.

The preparation of need testing solution: precision measures this product 10ml, 4 times (20ml, 20ml, 15ml, 15ml) is extracted with the shaking of water saturated n-butyl alcohol, merge n-butanol extracting liquid, with ammonia examination washing 2 times, every 20ml, discard ammonia solution, n-butyl alcohol recycling design is to dry, residue methanol dissolves and is transferred in 10ml measuring bottle, adds methanol and shakes up filtration to scale, takes continuous liquid and get final product.

Algoscopy: precision is drawn reference substance solution and supplies to try each 10 μ l respectively, injects high performance liquid chromatograph, measures, to obtain final product.

The QIXUEKANG KOUFUYE prepared in Example 9, embodiment 10, embodiment 19, embodiment 20 and comparative example 1 and comparative example 2 respectively measures content, and result is as shown in table 2.

Table 2:

Knowable to above-mentioned testing result, the QIXUEKANG KOUFUYE Panax Notoginseng saponin R compared with QIXUEKANG KOUFUYE prepared by commonsense method, in QIXUEKANG KOUFUYE of the present invention prepared by preparation method of the present invention₁, ginsenoside Rg₁, ginsenoside Rb₁Three kinds of active ingredient total contents can increase substantially, and can improve 50%-120%.

2, accelerated stability test: the QIXUEKANG KOUFUYE sample that Example 9, embodiment 10, embodiment 19, embodiment 20, comparative example 1, comparative example 2 prepare, place 6 months under the conditions of temperature 40 DEG C ± 2 DEG C, relative humidity 75% ± 5% respectively, it is accelerated stability test, respectively the 0th, 1,2,3, sampling in 6 months, carry out quality testing.Measurement result is as shown in table 3.

Table 3:

Knowable to above-mentioned accelerated stability test result, the QIXUEKANG KOUFUYE prepared by preparation method of the present invention was when acceleration for stabilization 6 months, character still keeps clear and bright and muddy or the most a small amount of fugitive precipitation of jog does not occur, and content of drug effect components is relatively stable, still higher than 0.50mg/ml.And the QIXUEKANG KOUFUYE using common preparation method to prepare occurs to precipitate in a large number when accelerating 1 month, character is the most against regulation；When accelerating 6 months, deposit clumps sinks to bottom caking, and character serious non-compliance specifies.

3, long-term stable experiment: the QIXUEKANG KOUFUYE sample that Example 9, embodiment 10, embodiment 19, embodiment 20, comparative example 1, comparative example 2 prepare, place 18 months under the conditions of temperature 25 DEG C ± 2 DEG C, relative humidity 60% ± 10% respectively, carry out long-term stable experiment, respectively the 0th, 3,6,9,12, sampling in 18 months, carry out quality testing.Measurement result is as shown in table 4.

Table 4:

Knowable to above-mentioned long-term stable experiment result, by preparation method of the present invention prepare QIXUEKANG KOUFUYE when keeping sample 18 months, character still keeps clear and bright and muddy or the most a small amount of fugitive precipitation of jog does not occur, and content of drug effect components is relatively stable, still higher than 0.50mg/ml.And the QIXUEKANG KOUFUYE using common preparation method to prepare occurs when keeping sample 1 month to precipitate in a large number, character is the most against regulation；When keeping sample 18 months, deposit clumps sinks to bottom caking, and character serious non-compliance specifies.

Case 1, Zhang, female, 35 years old, doctor.Pale white complexion is simple and unadorned, shortness of breath and palpitation, weak dizziness, and lack of appetite is indigestion and loss of appetite, light red tongue, thready pulse.Routine blood test, hepatic and renal function, normal ECG.Chinese medical discrimination belongs to deficiency of both QI and blood.Take embodiment 9 and prepare QIXUEKANG KOUFUYE, each 20ml, every day 2 times, within 7 days, be a course for the treatment of.After treatment, symptom and sign disappears substantially, and appetite recovers, and picture of the tongue, pulse condition are normal, occurs without adverse events.Routine blood test, routine urinalysis, electrocardiogram, hepatic and renal function etc. show no obvious abnormalities.

Case 2, Hu, man, 61 years old.Lusterless complexion, weak, insomnia, dizzy etc., light red tongue, white and thin fur, stringy and thready pulse.Chinese medical discrimination belongs to deficiency of both QI and blood.Taking the QIXUEKANG KOUFUYE of embodiment 10 preparation, each 20ml, every day 2 times, 7 days is a course for the treatment of.Clinical symptom disappearance after treatment, ALT, Cr, BUN, electrocardiogram blood, routine urinalysis are showed no obvious abnormalities.

Case 3, Wang, man, 55 years old.Lusterless complexion, weak, anorexia, cardiopalmus, light red tongue, white and thin fur, stringy and thready pulse.HGB115g/L, other indexs of routine blood test, routine urinalysis, hepatic and renal function etc. show no obvious abnormalities.Chinese medical discrimination belongs to deficiency of both QI and blood.Taking the QIXUEKANG KOUFUYE of embodiment 19 preparation, each 20ml, every day 2 times, 7 days is a course for the treatment of.Clinical symptom disappearance after treatment, ALT, Cr, BUN, electrocardiogram, blood, routine urinalysis all show no obvious abnormalities with comparing before treatment.

Case 4, fourth, female, 43 years old.Lustreless complexion, dizzy, uneasy sleeping at night, cardiopalmus, Na Gu reduces, light red tongue, thin fur, thready pulse.Routine blood test, routine urinalysis, hepatic and renal function etc. show no obvious abnormalities.Chinese medical discrimination belongs to deficiency of both QI and blood.Taking the QIXUEKANG KOUFUYE of embodiment 20 preparation, each 20ml, every day 2 times, 7 days is a course for the treatment of.After treatment, clinical symptoms is obviously improved, and sleep is obviously improved, and cardiopalmus is obviously improved, and Na Gu recovers, and dizziness disappears, and electrocardiogram blood, routine urinalysis are showed no obvious abnormalities.

Above scheme it can be seen that select the QIXUEKANG KOUFUYE prepared of the present invention for treating deficiency syndrome, evident in efficacy.QIXUEKANG KOUFUYE is fresh Radix Notoginseng or Radix Notoginseng, the Radix Astragali, Radix Ginseng, Radix Puerariae or the compound preparation of Pachyrhizua angulatus composition, and primary efficacy is benefiting vital QI and blood, it is adaptable to various deficiency syndrome, hypoimmunity etc..Traditional medicine is thought, qi being the governor of blood, QI invigorating then hemopoietic.QIXUEKANG KOUFUYE has boosting qi and nourishing yin hemopoietic, the body resistance strengthening and constitution consolidating, strengthening by means of tonics, spleen invigorating benefit god, anti-ageing effect, can be used for tumor patient because of the treatment of the symptom such as yin deficiency syndrome, leukopenia after Radiotherapy chemotherapy.

This programme observe altogether meet the deficiency syndrome such as 100 example QI and blood deficiency of inclusive criteria and cause lusterless complexion, spiritlessness and weakness, dizziness and blurred vision, shortness of breath and palpitation, spontaneous perspiration, the symptom such as lazy speech, insomnia, indigestion and loss of appetite, the emaciated physique of lack of appetite, in therapeutic process, the course of disease does not terminates and anaphylaxis or serious adverse reaction person occurs, research should be terminated, rejected.100 examples are divided into two groups, often organize 50 examples, and wherein treatment group takes QIXUEKANG KOUFUYE prepared by the embodiment of the present invention, and matched group takes comparative example 1, the medicine of comparative example 2 preparation.Therapeutic process is showed no obvious abnormalities and untoward reaction.

Curative effect judging standard:

1, clinical recovery: after treatment, clinical symptoms, sign disappear or substantially disappear.

2, effective: after treatment, clinical symptoms, sign are obviously improved.

3, effective: after treatment, clinical symptoms, sign all take a favorable turn.

4, invalid: after treatment, clinical symptoms, sign are all not improved, even increase the weight of.

After treatment terminates, through statistics, treatment group and matched group efficacy result are as follows:

Above-mentioned data are inputted SPSS 13.0 software, number of cases is weighted, K the independent sample inspection using non parametric tests carries out data analysis (result is as follows), understands P=0.002 ＜ 0.05 from data results, and treatment group, matched group result of the test exist significant difference.

Ranks

Test Statistics(a)

a Grouping Variable:group

In place of this place embodiment is to the claimed non-limit of technical scope midrange, the most all in the scope of protection of present invention.

The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all any amendment, equivalent and improvement etc. made within the spirit and principles in the present invention, should be included within the scope of the present invention.

Claims (10)

1. the preparation method of a QIXUEKANG KOUFUYE, it is characterised in that described preparation method comprises the steps:

Take fresh Radix Notoginseng or Radix Notoginseng, Radix Ginseng, Radix Puerariae or Pachyrhizua angulatus mixing, according to fluid extract and the percolation ethanol as solvent with concentration as 45-75% under extractum item, impregnate 24 hours, slowly percolation, collect percolate medical material amount 6-20 times, reclaiming ethanol, being evaporated to relative density at 50-60 DEG C is the extracting solution of 1.02-1.06；By extracting solution by first adjust pH value to 6-14, reconcentration obtains standby extractum 1, or is first stood by extracting solution, filters, then filtrate is condensed into extractum then by extractum dilute after adjust pH value to 6-14, obtain standby filtrate 1；

Taking the Radix Astragali, soak by water for several times, filters, and it is the clear paste of 1.10-1.15 that filtrate is concentrated into relative density at 50-60 DEG C, adds 80-95% ethanol, makes concentration of alcohol reach 45-75%, stands 48 hours, filters, filtrate recycling ethanol；Filtrate is regulated pH value to 6-14, then filtrate is concentrated to give standby extractum 2, or first filtrate is condensed into after extractum is diluted by extractum again and adjusts pH value to 6-14, obtain standby filtrate 2；

Standby extractum 1 and standby extractum 2 are mixed with the adjuvant of QIXUEKANG KOUFUYE, or standby filtrate 1 and standby filtrate 2 are mixed with the adjuvant of QIXUEKANG KOUFUYE；Adding in mixed material after purified water makes ormal weight and boil, regulation pH value is to 4.0-6.0, and last microporous filter processes and prepares QIXUEKANG KOUFUYE.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 1, it is characterised in that use K₂CO₃、KHCO₃, NaOH, KOH, lime water [Ca (OH)₂]、Na₂CO₃、NaHCO₃, strong aqua ammonia, Ba (OH)₂In one or more any ratios mixture regulation pH value.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 1, it is characterized in that, QIXUEKANG KOUFUYE includes main material and adjuvant, main material includes fresh Radix Notoginseng or Radix Notoginseng, the Radix Astragali, Radix Ginseng, Radix Puerariae or Pachyrhizua angulatus, main material consists of: fresh Radix Notoginseng 17-1700 part (or Radix Notoginseng 4-450g), Radix Astragali 10-1000 part, Radix Ginseng 2-200 part, Radix Puerariae or Pachyrhizua angulatus 1-140 part.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 3, it is characterized in that, the main material of QIXUEKANG KOUFUYE consists of: fresh Radix Notoginseng 34-850 part (or Radix Notoginseng 9-225g), Radix Astragali 20-500 part, Radix Ginseng 4-100 part, Radix Puerariae or Pachyrhizua angulatus 3-70 part.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 4, it is characterized in that, in described QIXUEKANG KOUFUYE, main material consists of: fresh Radix Notoginseng 85-340 part (or Radix Notoginseng 22-90g), Radix Astragali 50-200 part, Radix Ginseng 10-40 part, Radix Puerariae or Pachyrhizua angulatus 7-28 part.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 1 or 5, it is characterised in that it is 50-500 part that described adjuvant amounts to (in terms of parts by weight), including correctives, preservative.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 1, it is characterised in that it is 0.1-10 μm that microporous filter processes the aperture of film used.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 7, it is characterised in that it is 0.15-8 μm that microporous filter processes the aperture of film used.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 1, it is characterised in that the preparation method of QIXUEKANG KOUFUYE comprises the steps:

Take fresh Radix Notoginseng or Radix Notoginseng, Radix Ginseng, Radix Puerariae or Pachyrhizua angulatus mixing, according to fluid extract and the percolation ethanol as solvent with concentration as 45-75% under extractum item, impregnate 24 hours, slowly percolation, collect percolate medical material amount 6-20 times, reclaim ethanol, being evaporated to relative density at 50-60 DEG C is 1.02-1.06, adjusts pH value to 6-14, stands, filters, it is the extractum of 1.15-1.20 that filtrate is concentrated into relative density at 50-60 DEG C, standby extractum 1；

Take the Radix Astragali, use soak by water respectively 1-3 time, each 1-3 hour, filtering, it is the clear paste of 1.10-1.15 that filtrate is concentrated into relative density at 50-60 DEG C, adds 80-95% ethanol, concentration of alcohol is made to reach 45-75%, stand 48 hours, filter, filtrate recycling ethanol, regulation pH value is to 6-14, standing, filter, it is the extractum of 1.20-1.25 that filtrate is concentrated into relative density at 50-60 DEG C, standby extractum 2；

Standby extractum 1, standby extractum 2 being mixed with the adjuvant of QIXUEKANG KOUFUYE, add after purified water makes ormal weight and boil, regulation pH value is to 4.0-6.0, and last microporous filter processes and prepares QIXUEKANG KOUFUYE.

The preparation method of QIXUEKANG KOUFUYE the most according to claim 1, it is characterised in that the preparation method of QIXUEKANG KOUFUYE comprises the steps:

Take fresh Radix Notoginseng or Radix Notoginseng, Radix Ginseng, Radix Puerariae or Pachyrhizua angulatus mixing, according to fluid extract and the percolation ethanol as solvent with concentration as 45-75% under extractum item, impregnate 24 hours, slowly percolation, collect percolate medical material amount 6-20 times, reclaim ethanol, being evaporated to relative density at 50-60 DEG C is 1.02-1.06, stands, filters, and filtrate is concentrated into the extractum 3 that relative density at 50-60 DEG C is 1.15-1.20, after being diluted by standby extractum, regulation pH value is to 6-14, stands, filters to obtain standby filtrate 1；

Take the Radix Astragali, use soak by water respectively 1-3 time, each 1-3 hour, filter, it is the clear paste of 1.10-1.15 that filtrate is concentrated into relative density at 50-60 DEG C, adds 80-95% ethanol, makes concentration of alcohol reach 45-75% ethanol, stand 48 hours, filtering, filtrate recycling ethanol, filtrate is concentrated into the extractum 4 that relative density at 50-60 DEG C is 1.20-1.25, after the dilution of standby extractum 4, regulation pH value is to 6-14, stands, filters to obtain standby filtrate 2；

Standby filtrate 1, standby filtrate 2 being mixed with the adjuvant of QIXUEKANG KOUFUYE, add after purified water makes ormal weight and boil, regulation pH value is to 4.0-6.0, and last microporous filter processes and prepares QIXUEKANG KOUFUYE.