CN105919932A - Altrenogest oral liquid and preparation method thereof - Google Patents
Altrenogest oral liquid and preparation method thereof Download PDFInfo
- Publication number
- CN105919932A CN105919932A CN201610414292.2A CN201610414292A CN105919932A CN 105919932 A CN105919932 A CN 105919932A CN 201610414292 A CN201610414292 A CN 201610414292A CN 105919932 A CN105919932 A CN 105919932A
- Authority
- CN
- China
- Prior art keywords
- altrenogest
- oral liquid
- preparation
- antioxidant
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to altrenogest oral liquid. The oral liquid comprises the following components in percentages by mass: 0.2-0.8% of altrenogest, 1-3% of a preservative, 0.005-0.05% of an antioxidant 1, 0.005-0.05% of an antioxidant 2, and the balance of vegetable oil, and the sum of the mass percentages of the components is 100%. The invention also relates to a preparation method of the altrenogest oral liquid. By the altrenogest oral liquid and the preparation method thereof, a preparation technology is simple, raw materials are low in cost and easy to obtain, and properties of a preparation are stable. The altrenogest oral liquid is suitable for industrial mass production, and therefore, the application prospect is wide.
Description
Technical field
The present invention relates to veterinary drug technical field, particularly relate to a kind of estrogens pharmaceutic preparation for livestock, specifically refer to a kind of alkene
Third pregnant element oral liquid and preparation method thereof.
Background technology
Altrenogest is the C of a kind of synthesis21Alkene progestogen, belong to 19-demethyl-testosterone, and it is that the activity that can be administered orally is pregnant
Hormone.Altrenogest by suppression endogenous promoting sexual gland hormone, LH and FSH concentration in blood, make increase follicle (> 20～
25 millimeters) shrink back, and then blocking-up is oestrused and is ovulated.In the rear half stage of medication treatment, after all increase follicles are shunk back, tightly
And then there will be the peak of a FSH secretion, this will start new round ovarian follicular growth and maturation.Phase can follower after the treatment
The regular increase of LH secretion, promotes growth and the maturation of follicle.This endocrine effect can make subject young female animal exist
Enter after drug withdrawal and oestrus.
Altrenogest is a kind of oral type activity progestogen, and it is to be similar to the binding mode of Natural progesterone to suppress promoting sexual gland hormone
Release.If taking altrenogest with the dosage of 15～20mg/d to gilt in continuous 14～18d, can successfully make it same
Step is oestrused, and can improve the reproductive performance of gilt.Due to altrenogest in water insoluble, and to light and heat less stable,
This preparation uses vegetable oil to be solvent to solve problem above, and adds corresponding adjuvant and prepare altrenogest oral liquid,
Stable in properties technique is simple.
Summary of the invention
It is an object of the invention to the shortcoming overcoming above-mentioned prior art, it is provided that a kind of better stability of preparation, preparation technology are simple
Altrenogest oral liquid and preparation method thereof.
To achieve these goals, altrenogest oral liquid of the present invention and preparation method thereof is as follows:
The altrenogest oral liquid of the present invention, it is mainly characterized by, including each component of following mass percent:
It is preferred that the mass percentage content of described altrenogest is 0.2～0.5%.
It is preferred that described preservative is benzyl alcohol.
It is preferred that described antioxidant 1 is tertiary butyl-4-hydroxy methoxybenzene.
It is preferred that described antioxidant 2 is 2,6 ditertiary butyl p cresol.
It is preferred that described vegetable oil is oral level soybean oil.
The preparation method of altrenogest oral liquid of the present invention, it is mainly characterized by, and described preparation method includes following step
Rapid:
Step (1): take described altrenogest and described preservative mixed dissolution by described mass percent, obtains
One solution；
Step (2): add the antioxidant 1 of described mass percent and described antioxidant after described vegetable oil heating
2, stirring and dissolving, obtain the second solution；
Step (3): add the first solution in the second described solution, obtains described altrenogest oral liquid after stirring.
It is preferred that the heating-up temperature in described step (2) is 40～60 DEG C.
Have employed altrenogest oral liquid in the present invention and preparation method thereof, compared with prior art, the allyl that the present invention provides
Pregnant element oral liquid preparation technology is simple, and raw material is cheap and easy to get, and preparation nature is stable, is suitable for industrialized great production, therefore has wide
Wealthy application prospect.
Detailed description of the invention
In order to more clearly describe the technology contents of the present invention, conduct further description below in conjunction with specific embodiment.
It is that the present invention is illustrated below in conjunction with embodiment and comparative example, it should be understood that it is real that the present invention is not limited to these
Execute example, also include the combination in any between specific embodiments.
The altrenogest oral liquid of the present invention, it is mainly characterized by, including each component of following mass percent:
The mass percentage content of altrenogest of the present invention is 0.2～0.5%；Described preservative is benzyl alcohol；Described
Antioxidant 1 is tertiary butyl-4-hydroxy methoxybenzene；Described antioxidant 2 is DBPC 2,6 ditertiary butyl p cresol；Described vegetable oil is
Oral level soybean oil.
The preparation method of altrenogest oral liquid of the present invention, it is mainly characterized by, and described preparation method includes following step
Rapid:
Step (1): take described altrenogest and described preservative mixed dissolution by described mass percent, obtains
One solution；
Step (2): add the antioxidant 1 of described mass percent and described antioxidant after described vegetable oil heating
2, stirring and dissolving, obtain the second solution；
Step (3): add the first solution in the second described solution, obtains described altrenogest oral liquid after stirring.
Wherein, the described heating-up temperature in step (2) is 40～60 DEG C；
Embodiment 1:
Each raw material (as a example by total amount is as 100mL) is weighed by following mass percent:
The altrenogest taking recipe quantity adds the preservative dissolving of recipe quantity；The vegetable oil taking recipe quantity adds recipe quantity
BHA/BHT is heated to 40～60 DEG C of dissolvings；Add altrenogest and benzyl alcohol solution, after stirring and get final product.
Embodiment 2:
Each raw material (as a example by total amount is as 100mL) is weighed by following mass percent:
The altrenogest taking recipe quantity adds the preservative dissolving of recipe quantity；The vegetable oil taking recipe quantity adds recipe quantity
BHA/BHT is heated to 40～60 DEG C of dissolvings；Add altrenogest and antiseptic solution, after stirring and get final product.
Embodiment 3:
Each raw material (as a example by total amount is as 100mL) is weighed by following mass percent:
The altrenogest taking recipe quantity adds the preservative dissolving of recipe quantity；The vegetable oil taking recipe quantity adds recipe quantity
BHA/BHT is heated to 40～60 DEG C of dissolvings；Add altrenogest and antiseptic solution, after stirring and get final product.
The outward appearance of observation above example gained altrenogest oral liquid, and carry out the mensuration of content, result is as shown in table 1.
Table 1
| Embodiment | Character | Content (%) |
| 1 | Pale yellow oily liquid body | 100.3 |
| 2 | Pale yellow oily liquid body | 99.7 |
| 3 | Pale yellow oily liquid body | 100.5 |
As shown in Table 1, the present invention provide altrenogest oral liquid in, medicaments uniformity is dispersed in disperse medium, be one relatively
Stable liquid preparation.
Have employed altrenogest oral liquid in the present invention and preparation method thereof, compared with prior art, the allyl that the present invention provides
Pregnant element oral liquid preparation technology is simple, and raw material is cheap and easy to get, and preparation nature is stable, is suitable for industrialized great production, therefore has wide
Wealthy application prospect.
In this description, the present invention is described with reference to its specific embodiment.But it is clear that still can make various
Amendment and conversion are without departing from the spirit and scope of the present invention.Therefore, description is regarded in an illustrative, rather than a restrictive.
Claims (8)
1. an altrenogest oral liquid, it is characterised in that described oral liquid includes each component of following mass percent:
Altrenogest oral liquid the most according to claim 1, it is characterised in that the mass percent of described altrenogest
Content is 0.2～0.5%.
Altrenogest oral liquid the most according to claim 1, it is characterised in that described preservative is benzyl alcohol.
Altrenogest oral liquid the most according to claim 1, it is characterised in that described antioxidant 1 is the tert-butyl group-4-
BHA.
Altrenogest oral liquid the most according to claim 1, it is characterised in that described antioxidant 2 is 2, the tertiary fourth of 6-bis-
Base paracresol.
Altrenogest oral liquid the most according to claim 1, it is characterised in that described vegetable oil is oral level soybean oil.
7. the preparation method of the altrenogest oral liquid according to any one of a claim 1 to 6, it is characterised in that described
Preparation method comprise the following steps:
Step (1): take described altrenogest and described preservative mixed dissolution by described mass percent, obtains
One solution；
Step (2): add the antioxidant 1 of described mass percent and described antioxidant after described vegetable oil heating
2, stirring and dissolving, obtain the second solution；
Step (3): add the first solution in the second described solution, obtains described altrenogest oral liquid after stirring.
Altrenogest oral liquid the most according to claim 7, it is characterised in that the described heating temperature in step (2)
Degree is 40～60 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610414292.2A CN105919932A (en) | 2016-06-13 | 2016-06-13 | Altrenogest oral liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610414292.2A CN105919932A (en) | 2016-06-13 | 2016-06-13 | Altrenogest oral liquid and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105919932A true CN105919932A (en) | 2016-09-07 |
Family
ID=56832977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610414292.2A Pending CN105919932A (en) | 2016-06-13 | 2016-06-13 | Altrenogest oral liquid and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105919932A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042485A (en) * | 2017-11-08 | 2018-05-18 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation and preparation method thereof |
| CN109260208A (en) * | 2018-08-30 | 2019-01-25 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation for animals and preparation method thereof |
| CN109464400A (en) * | 2018-12-29 | 2019-03-15 | 佛山市南海东方澳龙制药有限公司 | Altrenogest solid pharmaceutical preparation and its preparation method and application |
| CN114344242A (en) * | 2022-01-04 | 2022-04-15 | 北京菲繁生物技术有限公司 | Alsopreglin soft sweets and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214035A (en) * | 1992-04-16 | 1993-05-25 | Hoechst-Roussel Agri-Vet Company | Thixotropic formulations |
| CN101522025A (en) * | 2006-08-22 | 2009-09-02 | 生物释放科技有限责任公司 | Suppression of estrus in mares by a single injection method |
| CN101541301A (en) * | 2006-11-20 | 2009-09-23 | 欧加农股份有限公司 | Helically-shaped drug delivery system |
-
2016
- 2016-06-13 CN CN201610414292.2A patent/CN105919932A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214035A (en) * | 1992-04-16 | 1993-05-25 | Hoechst-Roussel Agri-Vet Company | Thixotropic formulations |
| CN101522025A (en) * | 2006-08-22 | 2009-09-02 | 生物释放科技有限责任公司 | Suppression of estrus in mares by a single injection method |
| CN101541301A (en) * | 2006-11-20 | 2009-09-23 | 欧加农股份有限公司 | Helically-shaped drug delivery system |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042485A (en) * | 2017-11-08 | 2018-05-18 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation and preparation method thereof |
| CN108042485B (en) * | 2017-11-08 | 2018-11-27 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation and preparation method thereof |
| CN109260208A (en) * | 2018-08-30 | 2019-01-25 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation for animals and preparation method thereof |
| CN109260208B (en) * | 2018-08-30 | 2021-04-30 | 宁波三生生物科技有限公司 | Veterinary altrenogest preparation and preparation method thereof |
| CN109464400A (en) * | 2018-12-29 | 2019-03-15 | 佛山市南海东方澳龙制药有限公司 | Altrenogest solid pharmaceutical preparation and its preparation method and application |
| CN114344242A (en) * | 2022-01-04 | 2022-04-15 | 北京菲繁生物技术有限公司 | Alsopreglin soft sweets and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105919932A (en) | Altrenogest oral liquid and preparation method thereof | |
| JP2012511035A5 (en) | ||
| CN100556413C (en) | Oil-soluble propolis soft capsule and preparation method thereof | |
| EP2699336A1 (en) | Process and device for adding hops in beer manufacture, and also hop product | |
| EP2664327A1 (en) | Topical pharmaceutical compositions comprising terbinafide and urea | |
| CN102132698A (en) | Green solvent for pesticide and application of green solvent | |
| CN101485625B (en) | Amoluofen emulsifiable paste | |
| CN110464702A (en) | A kind of ointment and preparation method thereof of gram of vertical boron sieve | |
| CN1899567A (en) | Wanhua oil spray for traumatic injury and preparing method | |
| CN104161723A (en) | Diclazuril solution and preparation method thereof | |
| CN108077930B (en) | Hold Omega-3 fatty acid microemulsion and preparation method thereof | |
| CN101862423A (en) | Preparation method for coix seed oil microemulsion | |
| CN103520101B (en) | A kind of vitamin A nano-emulsion and preparation method thereof | |
| CN103393754B (en) | A kind of Cinnamomum longepaniculatum leaf volatile oil emulsion in water | |
| CN104886072A (en) | Tebuconazole emulsion in water | |
| CN101467960B (en) | Terbinafine hydrochloride emulsifiable paste and preparation method thereof | |
| CN104173227B (en) | Gel skin care item preparation method and making apparatus based on glycerine and odium stearate | |
| CN106176769A (en) | Long-acting veterinary Ursocycline injection and preparation method thereof | |
| CN101797388B (en) | Matrix of suppository or paste medicine for treating prostatitis and preparation method thereof | |
| CN114028325B (en) | Tacrolimus ointment preparation | |
| CN104434990A (en) | Male silkworm moth oil micro-emulsion | |
| CN103127138A (en) | Halometasone preparation containing protective agent and preparation method thereof | |
| CN101513531B (en) | Soft capsule matrix and preparation method thereof | |
| CN105708842B (en) | A topical pharmaceutical composition | |
| CN107822908A (en) | A kind of fruits and vegetables elite face message cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160907 |
|
| RJ01 | Rejection of invention patent application after publication |