CN105919576A - Pressure difference monitoring device based on femoral artery stent and method based on pressure difference monitoring device - Google Patents

Pressure difference monitoring device based on femoral artery stent and method based on pressure difference monitoring device Download PDF

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CN105919576A
CN105919576A CN201610393367.3A CN201610393367A CN105919576A CN 105919576 A CN105919576 A CN 105919576A CN 201610393367 A CN201610393367 A CN 201610393367A CN 105919576 A CN105919576 A CN 105919576A
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femoral artery
stent
integrated circuit
based
rf transceiver
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CN201610393367.3A
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Chinese (zh)
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任勇
吴巍巍
史清宇
刘磊
王景璟
李�灿
孟越
马骏
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任勇
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Publication of CN105919576A publication Critical patent/CN105919576A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031Implanted circuitry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007Evaluating blood vessel condition, e.g. elasticity, compliance
    • A61B5/02014Determining aneurysm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/0215Measuring pressure in heart or blood vessels by means inserted into the body
    • A61B5/02158Measuring pressure in heart or blood vessels by means inserted into the body provided with two or more sensor elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6862Stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6876Blood vessel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts

Abstract

The invention relates to a pressure difference monitoring device based on a femoral artery stent and a method based on the pressure difference monitoring device. The pressure difference monitoring device is characterized by comprising the femoral artery stent, two integrated circuits and external processing equipment, wherein the femoral artery stent is utilized as an antenna, and the two integrated circuits are fixedly arranged at an inlet and an outlet of a blood vessel of the femoral artery stent respectively; each integrated circuit comprises an energy supply module, a pressure sensor, a storage device, a data processor and a first radio frequency transceiving module, the energy supply module is used for supplying electric power to the integrated circuit, the pressure sensor is used for transmitting detected blood pressure signals to the data processor through the storage device, the data processor is used for converting the blood pressure signals to digital signals, and the first radio frequency transceiving module is used for transmitting the digital signals to the external processing equipment through the femoral artery stent. The device and the method can be widely applied to condition monitoring of femoral artery diseases.

Description

基于股动脉支架的压强差监测装置及其方法 Based femoral artery stents differential pressure monitoring apparatus and method

技术领域 FIELD

[0001] 本发明是关于一种基于股动脉支架的压强差监测装置及其方法,设及医疗监测技术领域。 [0001] The present invention relates to a femoral artery stents based on pressure differential monitoring apparatus and method, and provided medical monitoring technical field.

背景技术 Background technique

[0002] 近年来股动脉疾病呈高发态势,动脉硬化是其中一种重要疾病,股动脉硬化的主要病因是在股动脉内膜一些脂类物质堆积而成白色斑块,造成动脉腔狭窄,使血流受阻,导致下肢组织缺血。 [0002] In recent years, the femoral artery disease as a high momentum, which is an important disease of atherosclerosis, a major cause of arteriosclerosis stocks in the femoral artery intima lipids deposited by a number of white patches, resulting in arterial stenosis, so that blocked blood flow, resulting in lower limb ischemia.

[0003] 股动脉支架是治疗股动脉栓塞的重要手段,股动脉支架介入手术完成后,需要进行定期复查。 [0003] femoral artery stenting is an important means of treatment of femoral artery thrombosis after femoral artery stents procedure is completed, the need for periodic review. 目前,股动脉支架一般是独立介入,其上不再附加任何其他部件。 Currently, stents are generally independent of femoral artery intervention, no longer attached to any other member thereon.

发明内容 SUMMARY

[0004] 针对上述问题,本发明的目的是提供一种体积小,福射小,同时可W对股动脉支架血压进行实时监测的基于股动脉支架的压强差监测装置及其方法。 [0004] In view of the above problems, an object of the present invention is to provide a small-volume, small-fu shot, while the stent W femoral artery blood pressure monitoring real-time monitoring of the pressure differential apparatus and method based on femoral artery stents.

[0005] 为实现上述目的,本发明采取W下技术方案:一种基于股动脉支架的压强差监测装置,其特征在于,该监测装置包括一股动脉支架、两集成电路和一外部处理设备;所述股动脉支架作为天线使用,两所述集成电路分别固定设置在所述股动脉支架的血管的入口和出口处;每一所述集成电路均包括一能量供应模块、一压力传感器、一存储器、一数据处理器和一第一射频收发模块,每一所述能量供应模块用于为所述集成电路供电;所述压力传感器将检测到的血压信号经所述存储器传输至所述数据处理器,所述数据处理器将血压信号转化为数字信号,并通过所述第一射频收发模块将数字信号经所述股动脉支架传输到所述外部处理设备。 [0005] To achieve the above object, the present invention adopts the technical scheme W: one kind of the pressure differential monitoring means based on femoral artery stent, characterized in that the monitoring device comprises an arterial stent, two integrated circuits and an external processing device; the femoral artery stent used as an antenna, are fixed to the two integrated circuits provided at the inlet and outlet of the femoral artery vascular stents; each of said integrated circuit comprises a power supply module, a pressure sensor, a memory , a data processor and a first RF transceiver module, each of said means for energy supply to the integrated circuit power supply; the pressure sensor detects the blood pressure via a memory transfer signal to the data processor , the data processor the blood pressure signal into a digital signal, and transmits the digital signals via the femoral artery to the bracket by the external processing device of the first RF transceiver module.

[0006] 进一步,所述外部处理设备包括发射天线、接收天线、第二射频收发模块、处理器、 传输模块和工作站,由所述第二射频收发模块经所述发射天线向体内的所述集成电路发射电磁波传输能量,同时经所述接收天线接收所述集成电路向体外发送的血压信号,所述射频收发模块将接收到的血压信号经所述处理器和传输模块发送至所述工作站。 [0006] Further, the external processing apparatus comprises a transmitting antenna, a receiving antenna, a second RF transceiver module, a processor module, and the transmission station by the RF transceiver module via the second transmission antenna to the integrated body transmitting electromagnetic energy transfer circuit, while the blood pressure through the receiving antennas a signal transmitted to the integrated circuit in vitro, the RF transceiver module to the blood pressure signal received via said processor module and sent to the transmitting station.

[0007] 进一步,所述股动脉支架包括两个W上的横向支撑结构和若干纵向支撑结构,每一所述横向支撑结构均由一金属丝弯曲形成环形支架,相邻两所述环形支架之间通过若干交错设置的所述纵向支撑结构固定连接,使支架撑开后形成网状结构,所述股动脉支架由等长的两节支架构成,每节所述支架的一端均与一所述集成电路输出端连接,每节所述支架的另一端分别设置有绝缘材料。 [0007] Further, the lateral femoral artery stent comprising a support structure and a plurality of W on two longitudinal support structures, each of said lateral support structure is formed by a metal wire bent annular support, the adjacent two of the annular holder between the longitudinal support structure by a plurality of staggered fixedly connected, form a network structure of the stent after the expansion, the femoral artery stent consists of two stents of equal length, each with a said one end of each section of the bracket the integrated circuit output terminal is connected, the other end of each section of the bracket are respectively provided with an insulating material.

[0008] 进一步,所述环形支架采用正弦波结构或银齿波结构。 [0008] Further, the annular stent using a sine wave or silver tooth wave structure.

[0009] 进一步,所述股动脉支架作为天线的谐振频率f设置为: [0009] Further, the femoral artery stent as the resonant frequency f of the antenna is set to:

[001 ( [001 (

Figure CN105919576AD00041

[0011]式中,N为环形支架的数量、η为环形支架中波形的起伏数量、1为纵向支撑结构的长度、Cl、C2和C3均为正系数。 [0011] In the formula, N is the number of annular support, [eta] is the number of undulating annular support of the waveform, 1 is the length of the longitudinal support structure, Cl, C2 and C3 are positive coefficients.

[0012] 进一步,两所述集成电路设置在一长条形结构上,长条形集成电路沿所述股动脉支架轴向布置。 [0012] Further, the integrated circuit provided on a two elongated structures, the elongated direction of the integrated circuit disposed axially femoral artery stents.

[0013] 进一步,每一所述集成电路均采用分段式结构,分段式集成电路沿股动脉支架轴向布置。 [0013] Further, each of the integrated circuit structure are made of segmented, segmented integrated circuit disposed axially along the femoral artery stents.

[0014] 进一步,每一所述集成电路均采用方形结构,包裹在其外部的生物可兼容性外壳采用圆形结构。 [0014] Further, each of the integrated circuit with a square configuration are wrapped using a circular structure outside thereof are biocompatible housing.

[0015] 进一步,每一所述集成电路均采用环形结构,环形集成电路所在平面与所述股动脉支架的切面平行。 [0015] Further, each of the integrated circuit are used annular structure, the annular section parallel with the plane of the integrated circuit to the femoral artery stents.

[0016] -种基于所述压强差监测装置的监测方法,其特征在于,包括W下内容:1)设置一包括有压力传感器、数据处理器、第一射频收发模块和外部处理设备的压强差监测装置,其中,外部处理设备包括接收天线、第二射频收发模块、处理器、传输模块和工作站;2)两个压力传感器分别采集股动脉支架血管两端的血压信号,并分别通过相应数据处理器处理后传输至第一射频收发模块,两第一射频收发模块对接收的血压信号分别进行调制后通过天线发送到外部处理设备;3)接收天线将接收到的股动脉支架血管两端的血压信号经第二射频收发模块进行解调后并经处理器处理后发送到工作站。 [0016] - monitoring method based on the kinds of pressure differential monitoring device, wherein the content comprises W: 1) is provided with a pressure comprises a pressure sensor, a data processor, a first RF transceiver module and an external processing apparatus difference monitoring means, wherein the external processing apparatus includes a receiving antenna, a second RF transceiver module, a processor, workstation, and a transmission module; 2) were collected from the two pressure sensors blood pressure signal across the femoral artery stent graft, respectively, by a corresponding data processor blood pressure signal across the femoral artery stent graft 3) receive antennas received; after transmitting a first RF transceiver module to transmit a first RF transceiver module of the two blood pressure signal received modulated treatment, respectively, to an external processing apparatus through the antenna after the second RF transceiver module demodulates and transmits to the workstation after processor.

[0017] 本发明由于采取W上技术方案,其具有W下优点:1、本发明包括股动脉支架、两集成电路和外部处理设备,两集成电路分别固定设置在股动脉支架血管的入口和出口处对股动脉支架血压进行监测,可W获得股动脉支架内血压情况,通过股动脉内支架两端的压强差能够有效地对股动脉支架的工作状态进行监测。 [0017] As a result of the present invention, the aspect W, W having the following advantages: 1, the present invention includes a femoral artery stents, two external processing devices and integrated circuits, two integrated circuits provided respectively at the inlet and outlet fixed to the femoral artery stent graft of the femoral artery to monitor blood pressure and stent, may be the femoral artery stent W obtained blood pressure, the operating state can be effectively femoral artery stents femoral artery was monitored by the pressure difference across the stent. 2、本发明由于采取实时检测的方式,病人无需去医院做造影即可了解自身健康状况,降低了成本和风险,减少了患者的痛苦,使医生得到的反馈更加快速有效。 2, due to the present invention take the form of real-time detection, the patient need not go to the hospital for angiography to understand their own health status, reducing the cost and risk, reduce the suffering of patients, the doctors get feedback more quickly and efficiently. 3、本发明可W在手术治疗植入支架的同时植入集成电路,避免病人二次手术的痛苦。 3, the integrated circuit of the present invention can be implanted at the same time W stent implantation surgery, the patient to avoid a second surgery pain. 本发明可W广泛应用于股动脉疾病的状态监测中。 The present invention can be widely applied to W femoral artery disease condition monitoring.

附图说明 BRIEF DESCRIPTION

[0018] 图1是本发明的集成电路结构示意图; [0018] FIG. 1 is a schematic view of an integrated circuit structure according to the present invention;

[0019] 图2是本发明的数据处理器采用NRF51822忍片时的结构示意图; [0019] FIG. 2 is a schematic structural diagram of a data processor NRF51822 tolerance sheet of the present invention employed;

[0020] 图3是本发明的外部处理设备结构示意图; [0020] FIG. 3 is a schematic view of an external processing device structure of the present invention;

[0021 ]图4是本发明股动脉支架采用银齿波形状结构示意图。 [0021] FIG. 4 is a schematic view of a silver tooth wave-shaped structure femoral artery stent using the present invention.

具体实施方式 Detailed ways

[0022] W下结合附图来对本发明进行详细的描绘。 The [0022] W to a detailed depiction of the present invention in conjunction with the accompanying drawings. 然而应当理解,附图的提供仅为了更好地理解本发明,它们不应该理解成对本发明的限制。 However, it should be understood that the drawings only provide a better understanding of the present invention, they should not be construed as limiting the present invention.

[0023] 如图1所示,本发明的基于股动脉支架的压强差监测装置,包括一股动脉支架、两集成电路和一外部处理设备;股动脉支架作为天线用于进行能量和信号传输,两集成电路分别固定设置在股动脉支架血管的入口和出口处,每一集成电路均包括一能量供应模块、 一压力传感器、一存储器、一数据处理器和一第一射频收发模块。 [0023] As shown in FIG. 1, the present invention is based on the pressure differential monitoring means femoral artery stent, the stent comprising a femoral artery, two integrated circuits and an external processing device; femoral artery stents as an antenna for the energy and signal transmission, fixing two integrated circuits provided respectively at the inlet and outlet of the femoral artery stent graft, each integrated circuit includes a power supply module, a pressure sensor, a memory, a data processor and a first RF transceiver module. 每一能量供应模块经作为天线的股动脉支架通过第一射频收发模块接收由外部处理设备福射至体内的电磁波,通过无线射频能量收集的方式为集成电路上其他部件供电。 Each power supply module is an antenna as the femoral artery stent by first RF transceiver module receives emitted by the external processing apparatus to the body Four electromagnetic waves collected by way of radio frequency energy to power the other components on the integrated circuit. 压力传感器将检测到的血压信号传输至存储器进行存储,数据处理器可从存储器读取数据,将其转化为数字信号,并加载集成电路ID、时间戳等信息,通过第一射频收发模块将数字信号经作为股动脉支架的天线传输到外部处理设备,完成数据测量、信号发射功能。 The blood pressure sensor transmitting detected signals to a memory for storage, the data processor can read data from the memory, it converted to a digital signal, and load the integrated circuit ID, time stamp information, by a first digital RF transceiver module signal via the transmission antenna as the femoral artery stent to external processing apparatus, data measurement is completed, the signal transmitting function. 其中,能量供应模块还可W采用微型电池作为替代,W便直接为集成电路上的各部件供电。 Wherein the energy supply module may be a miniature battery W Alternatively, each component W will directly supply on the integrated circuit.

[0024] 在一个优选的实施例中,如图2所示,数据处理器可W采用NORDIC公司生产的NRF51822忍片。 [0024] In a preferred embodiment, shown in Figure 2, the data processor may be employed W NORDIC sheet produced NRF51822 tolerance. 该忍片ADC转换引脚J6并联连接两压力传感器,VDD电源引脚J1连接能量供应模块,XCUXC2引脚J37-J38连接时钟电路,¥孤_口4、4饥'1、4脚2引脚130-扔2连接第一射频收发模块,P0.01引脚巧连接电源检测电路,DEC1引脚J39经第Ξ电容C3接地;VSS引脚J33、 J34并联后接地,VSS引脚J33、J34并联后连接能量供应模块,位于AVDD引脚与VSS引脚之间并联第四电容C4dDEC巧侧J29经第十电容CIO与EXP_GND引脚J49连接后接地;VSS引脚J13 接地,SWCLK引脚经第Ξ电阻R3接地。 The ADC pin tolerance J6 two parallel converter connected to the pressure sensor chip, VDD supply pin connector J1 energy supply module, XCUXC2 pin connector J37-J38 clock circuit, ¥ _ solitary hungry mouth 4,4 ', 4 foot pin 2 130- 2 is connected to throw a first RF transceiver module, P0.01 power detection circuit connected to pin Qiao, DEC1 pin J39 capacitor C3 is grounded through the first Ξ; the VSS pins J33, J34 after parallel ground, VSS functions J33, J34 parallel after connecting power supply module, positioned in parallel with the ground side of the fourth capacitor C4dDEC Qiao J29 via a tenth capacitor CIO and EXP_GND J49 between pin and VSS pin AVDD pin connector; J13 ground VSS pin, the first pin of SWCLK Ξ the resistor R3 is grounded.

[0025] 其中,时钟电路包括第一电容C1、第二电容C2和晶振XI,晶振XI控制端管脚1经第二电容C2接地,晶振XI输出端管脚2经第一电容C1接地;晶振XI控制端管脚1还连接至NRF51822忍片的XC1引脚J37,晶振XI输出端管脚2还连接至NRF51822忍片的XC2引脚J38。 [0025] wherein the clock circuit includes a first capacitor C1, second capacitor C2 and the crystal XI, the second capacitor C2 to ground terminal pin control oscillator 1 via XI, XI oscillator output terminal pin 2 is grounded via the first capacitor C1; Crystal XI control terminal is also connected to pin 1 of J37 NRF51822 tolerance pin XC1 sheet XI oscillator output terminal pin 2 is also connected to pin J38 NRF51822 XC2 tolerance sheet. [00%] 电源检测电路包括第一电阻R1、第二电阻R2和电容C13,第一电阻R1-端接高电平(即能量供应模块),第一电阻R1另一端经第二电阻R2接地;位于第二电阻R2两端并联电容C13,且第一电阻R1另一端与第二电阻R2之间通过导线连接至NRF51822忍片的P0.01引脚J5〇 [00%], the power detection circuit includes a first resistor R1, second resistor R2 and the capacitor C13, the first termination resistor R1- high (i.e., energy supply module), the other end of the first resistor R1 is grounded via a second resistor R2 ; a second resistor R2 connected in parallel at both ends of the capacitor C13, and between the other end of the first resistor R1 and second resistor R2 is connected by a wire to NRF51822 sheet P0.01 tolerance pin J5〇

[0027] 在一个优选的实施例中,如图3所示,外部处理设备包括发射天线、接收天线、第二射频收发模块、处理器、传输模块和工作站。 [0027] In a preferred embodiment, as shown, the external processing apparatus comprises a transmitting antenna, a receiving antenna, a second RF transceiver module, a processor, a workstation 3 and the transmission module. 由第二射频收发模块经发射天线向体内的集成电路发射电磁波传输能量,同时并经接收天线接收体内的集成电路向体外发出的血压信号;第二射频收发模块将接收到的血压信号经处理器、传输模块发送至工作站,W备后续使用。 Transmitted by a second RF transceiver module to the integrated circuit via the transmit antennas transmit the electromagnetic energy in the body, while the body and receives the blood pressure signal sent to the integrated circuit via the receiving antenna vitro; a second RF transceiver module received blood pressure signal processor , the transmission module transmits to the workstation, W for subsequent use. 其中,工作站可W采用智能手机、智能手表等移动终端。 Wherein W workstation smart phones, smart watch other mobile terminal.

[0028] 在一个优选的实施例中,工作站内设置有信号处理系统,信号处理系统计算安装有股动脉支架的血管两端的压强差,并判断在预设时间内获取的压强差是否在预设范围内,从而判断安装有股动脉支架的血管是否出现了再狭窄的现象。 [0028] In a preferred embodiment, the station is provided with a signal processing system, signal processing system calculates the pressure across the mounting bracket has a femoral artery vascular difference, and determines whether the pressure difference obtained within a preset time preset the range in order to determine the installation femoral artery vascular stent restenosis whether there has been a phenomenon.

[0029] 在一个优选的实施例中,如图4所示,股动脉支架包括两个W上的横向支撑结构1 和若干纵向支撑结构2,每一横向支撑结构1均由一金属丝弯曲形成环形支架;相邻两环形支架之间通过若干交错设置的纵向支撑结构2固定连接,使支架撑开后形成网状结构。 [0029] In a preferred embodiment, as shown in FIG femoral artery stent structure comprises a lateral support on two longitudinal support structure W is a number of 1 and 2, each lateral support structure 1 is formed by bending a metal wire 4 annular support; staggered longitudinal support structure 2 is connected by a plurality of fixed annular support between two adjacent mesh structure is formed after the stent distraction. 环形支架可W采用正弦波结构或银齿波结构。 Annular support structure may be a sine wave or a W silver tooth wave structure. 股动脉支架由等长的两节支架构成,每节支架的一端均与一集成电路输出端连接,由两节支架构成集成电路天线的两极进行馈电。 Femoral artery stent consists of two stents of equal length, one end of each brace are connected to an output terminal of the integrated circuit, the two poles of an integrated circuit constituting the antenna holder is fed. 其中,在每节支架的另一端分别设置有绝缘材料,通过绝缘材料固定该节支架结构的稳固性。 Wherein the other end of each brace are provided with an insulating material, the stability of the brace fixed structure by an insulating material. 在本实施例中,该股动脉支架作为天线时,其福射性能更好,频带更宽。 In the present embodiment, as the antenna when the stock artery stent, which better radio performance Fu, wider band.

[0030] 股动脉支架作为天线的谐振频率f设置为: [0030] femoral artery stents as resonance frequency f of the antenna is set to:

[0031] [0031]

Figure CN105919576AD00061

[0032] 式中,N为环形支架的数量、η为环形支架中波形的起伏数量、1为纵向支撑结构的长度、Ci、C2和C3均为正系数。 [0032] In the formula, N is the number of annular support, [eta] is the number of undulating annular support of the waveform, 1 is the length of the longitudinal support structure, Ci, C2 and C3 are positive coefficients. 其中,Ν、η和1越大,谐振频率越小。 Wherein, Ν, η 1, and the larger, the smaller the resonance frequency. 使用时,由于不能调整股动脉支架的尺寸,所W通过调整环形支架的数量Ν、环形支架中波形的起伏数量nW及纵向支撑结构的长度1来调整天线的谐振频率。 When used, because it is not resized femoral artery stent, by adjusting the number of the W v annular support, the length of the undulating waveform number nW annular support and a longitudinal support structure to adjust the antenna resonant frequency.

[0033] 在一个优选的实施例中,每一集成电路外部包裹有生物可兼容性外壳。 [0033] In a preferred embodiment, each of the integrated circuit is wrapped with the outer shell are biocompatible. 每一集成电路可W通过一固定栓固定在股动脉支架外侧,固定栓的一端焊接在集成电路的焊盘上, 另一端与股动脉支架外壁连接在一起;固定栓暴露在生物可兼容性外壳外面,生物可兼容性外壳能避免产生人体的排异反应。 W in each integrated circuit may be an integrated circuit pad, and the other end connected to the outer wall of the femoral artery by means of a bracket welded to one end of the bolt fixed to the outside femoral artery stent, fixing bolt; stationary pin exposed are biocompatible housing outside, are biocompatible casing can avoid rejection of the human body. 优选的,生物可兼容性外壳有一定柔初性,可W弯曲。 Preferably, the bio-compatibility of the housing there is a certain flexibility First, W can be bent. 生物可兼容性外壳的材料优选采用聚二甲基硅氧烷(PDMS)。 Are biocompatible housing material is preferably used polydimethylsiloxane (PDMS). 制作时,可将集成电路放在模具中,用聚二甲基硅氧烷进行填充封装,把固定栓留在外面从而制备出带生物可兼容性外壳和固定栓的集成电路。 Production, an integrated circuit may be placed in a mold, the package is filled with polydimethylsiloxane, the fixed bolt to prepare a stay outside the integrated circuit and the housing are biocompatible with the fixed bolt.

[0034] 在一个优选的实施例中,固定栓和股动脉支架的焊点处还可W覆盖有生物可兼容性药膜。 [0034] In a preferred embodiment, the solder joints and femoral arteries fixed bolt bracket may also be covered with a bio-compatible W pellicles. 由于固定栓和股动脉支架的焊接可能会破坏股动脉支架外面的生物可兼容性外壳,在固定栓和股动脉支架焊接处覆盖一层药膜,可进一步防止人体的排异反应发生。 Because the femoral artery and fixed by welding bolt holder may break out femoral artery stents are biocompatible housing, the stationary pin covered with pellicles welding femoral artery and the stent, the body can be further prevented rejection occurs.

[0035] 在一个优选的实施例中,每一集成电路均由柔性电路板和形成在该柔性电路板上由晶圆制成的各模块电路忍片制成,W适应体积限制,并能随股动脉支架形状的变化进行弯曲,但是其长度不超过股动脉支架长度,且为了不堵塞血管,其截面积不超过0.5mm X 0.5mm。 [0035] In a preferred embodiment, each integrated circuit is formed by a flexible circuit board and the circuit modules of the flexible circuit board made of a substrate wafer made of tolerance, W accommodate the volume restriction, and can with femoral artery stent changes shape bending, but not longer than the femoral artery stent length, and in order not to block blood vessels, which cross-sectional area of ​​not more than 0.5mm X 0.5mm.

[0036] 在一个优选的实施例中,两集成电路可W设置在一长条形结构上,长条形集成电路沿股动脉支架轴向布置;每一集成电路均可W采用分段式结构,分段式集成电路沿股动脉支架轴向布置,集成电路外部包裹有生物可兼容性外壳;每一集成电路均可W采用方形结构,包裹在其外部的生物可兼容性外壳采用圆形结构;每一集成电路均可W采用环形结构,环形集成电路所在平面与股动脉支架的切面平行。 [0036] In a preferred embodiment, two integrated circuit may be disposed on a W elongated structures, the elongated integrated circuit disposed axially along the femoral artery stent; each W may employ an integrated circuit sub-structure , segmented along the femoral artery stent axially integrated circuit arrangement, the integrated circuit has external wrap are biocompatible housing; each W may be an integrated circuit with a square configuration, wrapping using a circular structure outside thereof are biocompatible housing ; each W may be an integrated circuit using the ring structure, the ring section parallel with the plane of the integrated circuit femoral artery stents.

[0037] 下面通过具体实施例详细说明采用本发明的基于股动脉支架的压强差监测装置对患者的血压进行监测的具体过程: [0037] The specific procedure will be described below based on the differential pressure monitoring means monitoring the blood pressure of the femoral artery of a patient the stent according to the present invention in detail by way of specific embodiments:

[0038] 1、两个压力传感器分别采集股动脉支架血管两端的血压信号,并分别通过相应数据处理器处理后传输至第一射频收发模块,两第一射频收发模块对接收的血压信号分别进行调制后通过天线发送到外部处理设备。 [0038] 1, two pressure sensors were collected from the femoral artery blood pressure signal across the stent graft, and through the corresponding data are transmitted to the processor a first RF transceiver module, a first RF transceiver module of the two blood pressure signals are received modulated transmission through the antenna to an external processing device.

[0039] 2、接收天线将接收到的股动脉支架血管两端的血压信号经第二射频收发模块进行解调后并经处理器处理后发送到工作站。 After demodulating [0039] 2, the receiving antenna will receive the blood pressure signal by a second RF transceiver module at both ends of the femoral artery and transmitted to the stent graft after the workstation processor.

[0040] 在具体实施例中,采用本发明的基于股动脉支架的压强差监测装置对股动脉支架工作状态进行检测的过程: [0040] In one embodiment, the process based on the differential pressure detecting means femoral artery to monitor femoral artery stent holder operating state of the specific embodiment of the present invention:

[0041] 设置在工作站内的信号处理系统将接收的安装有股动脉支架的血管两端的压强差与预设值进行比较,如果在设定时间内股动脉支架血管两端的压强差处于预设范围内, 确定股动脉支架工作状态良好,认为安装有股动脉支架的血管没有发生再狭窄现象;如果在设定时间内股动脉支架血管两端的压强差不在预设范围内,确定股动脉支架工作状态出现异常,认为安装有股动脉支架的血管发生再狭窄现象。 The pressure difference across the vessel with a preset value [0041] is provided a signal processing system in the station will receive the femoral artery with a stent mounted by comparing the difference within a preset range if the pressure within the set time of femoral artery at both ends of the stent graft determining femoral artery holder in good working condition, that is attached to the femoral artery stent restenosis has not occurred; if the pressure across the femoral artery stent graft within the set time difference out of a preset range, the femoral artery to determine abnormal operating state of the stent that is attached to the femoral artery vascular stent restenosis phenomenon. 另外,可W根据获取的股动脉支架血管两端的压强差作为参考值进一步了解股动脉支架的工作情况。 In addition, W can be understood as a reference value for further work femoral artery holder according to the pressure difference across the femoral artery stent graft acquired.

[0042] 上述各实施例仅用于说明本发明,其中各部件的结构、连接方式和制作工艺等都是可W有所变化的,凡是在本发明技术方案的基础上进行的等同变换和改进,均不应排除在本发明的保护范围之外。 [0042] The above-described embodiments are merely illustrative of the invention, wherein the structure and production process of each connection member and the like are W may vary, equivalents, changes and modifications usually carried out on the basis of the technical solution of the present invention , should not be excluded from the scope of the present invention.

Claims (10)

1. 一种基于股动脉支架的压强差监测装置,其特征在于,该监测装置包括一股动脉支架、两集成电路和一外部处理设备; 所述股动脉支架作为天线使用,两所述集成电路分别固定设置在所述股动脉支架的血管的入口和出口处;每一所述集成电路均包括一能量供应模块、一压力传感器、一存储器、 一数据处理器和一第一射频收发模块,每一所述能量供应模块用于为所述集成电路供电; 所述压力传感器将检测到的血压信号经所述存储器传输至所述数据处理器,所述数据处理器将血压信号转化为数字信号,并通过所述第一射频收发模块将数字信号经所述股动脉支架传输到所述外部处理设备。 1. Based on the differential pressure monitoring means femoral artery stents, characterized in that the monitoring device comprises an arterial stent, two integrated circuits and an external processing device; the femoral artery stent used as an antenna, the two IC are respectively fixedly provided at the inlet and outlet of the femoral artery vascular stents; each of said integrated circuit comprises a power supply module, a pressure sensor, a memory, a data processor and a first RF transceiver module, each a means for the energy supply to the integrated circuit power supply; the pressure sensor detects the blood pressure signal is transmitted to the memory of the data processor, the data processor blood pressure signal into a digital signal, and the digital signal transmitted via the femoral artery to the bracket by the external processing device of the first RF transceiver module.
2. 如权利要求1所述的基于股动脉支架的压强差监测装置,其特征在于,所述外部处理设备包括发射天线、接收天线、第二射频收发模块、处理器、传输模块和工作站,由所述第二射频收发模块经所述发射天线向体内的所述集成电路发射电磁波传输能量,同时经所述接收天线接收所述集成电路向体外发送的血压信号,所述射频收发模块将接收到的血压信号经所述处理器和传输模块发送至所述工作站。 2. Based on the differential pressure monitoring apparatus 1 of claim femoral artery stent, wherein said external processing apparatus comprises a transmitting antenna, a receiving antenna, a second RF transceiver module, a processor, a workstation, and a transmission module, a the RF transceiver module via the second transmit antennas transmit the electromagnetic energy to the body of the integrated circuit, while the blood pressure through the receiving antennas a signal transmitted to the integrated circuit in vitro, the received RF transceiver module blood pressure signals and the processor module transmits to the transmitting station.
3. 如权利要求1所述的基于股动脉支架的压强差监测装置,其特征在于,所述股动脉支架包括两个以上的横向支撑结构和若干纵向支撑结构,每一所述横向支撑结构均由一金属丝弯曲形成环形支架,相邻两所述环形支架之间通过若干交错设置的所述纵向支撑结构固定连接,使支架撑开后形成网状结构,所述股动脉支架由等长的两节支架构成,每节所述支架的一端均与一所述集成电路输出端连接,每节所述支架的另一端分别设置有绝缘材料。 3. Based on the differential pressure monitoring apparatus 1 of claim femoral artery stent, wherein the stent comprises two or more femoral artery lateral support structure and a plurality of longitudinal support structure, each of said lateral support structures were formed by a metal wire bent annular support, said longitudinal support structure by a plurality of annular support between the two adjacent staggered fixedly connected to form a network structure of the stent after the expansion, the femoral artery stent is formed of equal length two stent configuration, one end of each of said stent sections are connected to the output terminal of an integrated circuit, the other end of each section of the bracket are respectively provided with an insulating material.
4. 如权利要求3所述的基于股动脉支架的压强差监测装置,其特征在于,所述环形支架采用正弦波结构或锯齿波结构。 4. Based on differential pressure monitoring device of claim 3 to claim femoral artery stent, wherein said annular stent using a sine wave or a sawtooth structure.
5. 如权利要求3或4所述的基于股动脉支架的压强差监测装置,其特征在于,所述股动脉支架作为天线的谐振频率f设置为: 5. The differential pressure monitoring means femoral artery stent of claim 3 or 4 based on claim, wherein the femoral artery stent as the resonance frequency f of the antenna is:
Figure CN105919576AC00021
式中,N为环形支架的数量、η为环形支架中波形的起伏数量、1为纵向支撑结构的长度、 Cl、C2和C3均为正系数。 Where, N is the number of annular support, [eta] is the number of undulating annular support of the waveform, 1 is the length of the longitudinal support structure, Cl, C2 and C3 are positive coefficients.
6. 如权利要求1或2或3或4所述的基于股动脉支架的压强差监测装置,其特征在于,两所述集成电路设置在一长条形结构上,长条形集成电路沿所述股动脉支架轴向布置。 6. Based on the pressure difference monitoring device 1 or 2 or 3 or 4, wherein the femoral artery stent as claimed in claim, characterized in that the two integrated circuits disposed on an elongated structure, the elongated along the IC said axially disposed femoral artery stents.
7. 如权利要求1或2或3或4所述的基于股动脉支架的压强差监测装置,其特征在于,每一所述集成电路均采用分段式结构,所述分段式集成电路沿股动脉支架轴向布置。 7. Based on the differential pressure monitoring apparatus 1 or 2 or 3 or 4, wherein the femoral artery stent as claimed in claim wherein each of said integrated circuit structure are made of a segmented, the segmented integrated circuit along femoral artery stent axially disposed.
8. 如权利要求1或2或3或4所述的基于股动脉支架的压强差监测装置,其特征在于,每一所述集成电路均采用方形结构,包裹在其外部的生物可兼容性外壳采用圆形结构。 8. Based on the differential pressure monitoring device 1 or 2 or 3 or 4, wherein the femoral artery stent as claimed in claim wherein each of said square integrated circuit structure are used, wrapping are biocompatible housing outside thereof with circular configuration.
9. 如权利要求1或2或3或4所述的基于股动脉支架的压强差监测装置,其特征在于,每一所述集成电路均采用环形结构,环形集成电路所在平面与所述股动脉支架的切面平行。 9. Based on a pressure difference monitoring device 1 or 2 or 3 or 4, wherein the femoral artery stent as claimed in claim wherein each of said integrated circuit are used annular structure, the annular plane of the integrated circuit and the femoral artery cut parallel to the stent.
10. -种基于如权利要求1~9任一项所述压强差监测装置的监测方法,其特征在于,包括以下内容: 1)设置一包括有压力传感器、数据处理器、第一射频收发模块和外部处理设备的压强差监测装置,其中,外部处理设备包括接收天线、第二射频收发模块、处理器、传输模块和工作站; 2) 两个压力传感器分别采集股动脉支架血管两端的血压信号,并分别通过相应数据处理器处理后传输至第一射频收发模块,两第一射频收发模块对接收的血压信号分别进行调制后通过天线发送到外部处理设备; 3) 接收天线将接收到的股动脉支架血管两端的血压信号经第二射频收发模块进行解调后并经处理器处理后发送到工作站。 10. - The method of monitoring the pressure differential based on kinds of monitoring apparatus of claims 1 to 9 as one of the preceding claims, characterized in that, including the following: 1) provided a pressure sensor comprising a data processor, a first RF transceiver module and the differential pressure monitoring means external processing apparatus, wherein the external processing apparatus includes a receiving antenna, a second RF transceiver module, a processor, workstation, and a transmission module; 2) were collected from the two pressure sensors blood pressure signal across the femoral artery stent graft, and transmitting the first RF transceiver module are two blood pressure received signal modulated by the data processor corresponding to the first transmitted RF transceiver module, respectively, to an external processing apparatus through the antenna; 3) receive antennas will receive the femoral artery after demodulating the second RF transceiver module at both ends of the stent graft blood pressure signal and transmitted to the processor after the workstation.
CN201610393367.3A 2016-06-06 2016-06-06 Pressure difference monitoring device based on femoral artery stent and method based on pressure difference monitoring device CN105919576A (en)

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