CN105832318A - Renal arterial stent based pressure difference monitoring device and renal arterial stent based pressure difference monitoring method - Google Patents

Renal arterial stent based pressure difference monitoring device and renal arterial stent based pressure difference monitoring method Download PDF

Info

Publication number
CN105832318A
CN105832318A CN201610392986.0A CN201610392986A CN105832318A CN 105832318 A CN105832318 A CN 105832318A CN 201610392986 A CN201610392986 A CN 201610392986A CN 105832318 A CN105832318 A CN 105832318A
Authority
CN
China
Prior art keywords
renal artery
stent
integrated circuit
rf transceiver
renal arterial
Prior art date
Application number
CN201610392986.0A
Other languages
Chinese (zh)
Inventor
任勇
吴巍巍
史清宇
刘磊
王景璟
李�灿
孟越
马骏
Original Assignee
任勇
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 任勇 filed Critical 任勇
Priority to CN201610392986.0A priority Critical patent/CN105832318A/en
Publication of CN105832318A publication Critical patent/CN105832318A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031Implanted circuitry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007Evaluating blood vessel condition, e.g. elasticity, compliance
    • A61B5/02014Determining aneurysm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/0215Measuring pressure in heart or blood vessels by means inserted into the body
    • A61B5/02158Measuring pressure in heart or blood vessels by means inserted into the body provided with two or more sensor elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6862Stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6876Blood vessel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts

Abstract

The invention relates to a renal arterial stent based pressure difference monitoring device and a renal arterial stent based pressure difference monitoring method. The device is characterized by comprising a renal arterial stent, two integrated circuits and external processing equipment; the renal arterial stent serves as an antenna, and the two integrated circuits are fixed to a vascular inlet and a vascular outlet of the renal arterial stent respectively; each integrated circuit comprises an energy supply module, a pressure sensor, a memory, a data processor and a first radio-frequency transceiving module, and each energy supply module is used for supplying power to the corresponding integrated circuit; each pressure sensor transmits detected blood pressure signals to the corresponding data processor through the corresponding memory, and then each data processor converts the blood pressure signals into digital signals and transmits the digital signals to the external processing equipment through the renal arterial stent by the aid of the corresponding first radio-frequency transceiving module. The renal arterial stent based pressure difference monitoring device and the renal arterial stent based pressure difference monitoring method can be widely applied to condition monitoring of renal arterial diseases.

Description

基于肾动脉支架的压强差监测装置及其方法 Based on the difference between the renal artery stenting pressure monitoring apparatus and method

技术领域 FIELD

[0001] 本发明是关于一种基于肾动脉支架的压强差监测装置及其方法,涉及医疗监测技术领域。 [0001] The present invention relates to an apparatus and method for monitoring the pressure differential renal Stent based, relates to a technical field of medical monitoring.

背景技术 Background technique

[0002] 近年来血管疾病呈高发态势,动脉硬化是其中一种重要疾病,其中的肾动脉硬化的主要病因是在肾动脉内膜一些脂类物质堆积而成白色斑块,造成动脉腔狭窄,使血流受阻,导致肾部组织缺血。 [0002] In recent years, vascular diseases as a high momentum, which is an important disease of atherosclerosis, a major cause of renal arteriosclerosis which is deposited in the renal artery intima made of some white patches of lipids, resulting in arterial stenosis, the blocked blood flow, resulting in kidney tissue ischemia.

[0003] 肾动脉支架是治疗肾动脉栓塞的重要手段,肾动脉支架介入手术完成后,需要进行定期复查。 [0003] Renal artery stenting is an important means of treatment of renal artery embolism, renal artery stents procedure is completed, the need for periodic review. 目前,肾动脉支架一般是独立介入,其上不再附加任何其他部件。 Currently, stents are generally independent of the renal artery intervention, no longer attached to any other member thereon.

发明内容 SUMMARY

[0004] 针对上述问题,本发明的目的是提供一种体积小,辐射小,同时可以对肾动脉支架血压进行实时监测的基于肾动脉支架的压强差监测装置及其方法。 [0004] In view of the above problems, an object of the present invention is to provide a small, low radiation, and can be a pressure difference monitoring device and a method based on real-time monitoring of renal artery stenting of the renal artery stenting blood pressure.

[0005] 为实现上述目的,本发明采取以下技术方案:一种基于肾动脉支架的压强差监测装置,其特征在于,该监测装置包括一肾动脉支架、两集成电路和一外部处理设备; [0005] To achieve the above object, the present invention adopts the following technical solutions: A differential pressure monitoring means based on renal artery stent, characterized in that the monitoring device comprises a renal artery stenting, two integrated circuits and an external processing device;

[0006] 所述肾动脉支架作为天线使用,两所述集成电路分别固定设置在所述肾动脉支架的血管的入口和出口处;每一所述集成电路均包括一能量供应模块、一压力传感器、一存储器、一数据处理器和一第一射频收发模块,每一所述能量供应模块用于为所述集成电路供电;所述压力传感器将检测到的血压信号经所述存储器传输至所述数据处理器,所述数据处理器将血压信号转化为数字信号,并通过所述第一射频收发模块将数字信号经所述肾动脉支架传输到所述外部处理设备。 [0006] The renal artery stent used as an antenna, are fixed to the two integrated circuits provided at the inlet and outlet of the renal artery vascular stents; each of said integrated circuit comprises a power supply module, a pressure sensor , a memory, a data processor and a first RF transceiver module, each of said means for supplying energy to power the integrated circuit; said blood pressure sensor via the memory to transmit the signal detected a data processor, the data processor the blood pressure signal into a digital signal, and the digital signal transmitted via the renal artery stent to said external processing apparatus via said first RF transceiver module.

[0007] 进一步,所述外部处理设备包括发射天线、接收天线、第二射频收发模块、处理器、 传输模块和工作站,由所述第二射频收发模块经所述发射天线向体内的所述集成电路发射电磁波传输能量,同时经所述接收天线接收体内所述集成电路发向体外的血压信号,所述射频收发模块将接收到的血压信号经所述处理器和传输模块发送至所述工作站。 [0007] Further, the external processing apparatus comprises a transmitting antenna, a receiving antenna, a second RF transceiver module, a processor module, and the transmission station by the RF transceiver module via the second transmission antenna to the integrated body transmission circuit transmits electromagnetic energy while the body via the receiving antennas sent to the integrated circuit in vitro blood pressure signal, the RF transceiver module to the blood pressure signal received via said processor module and sent to the transmitting station.

[0008] 进一步,所述肾动脉支架包括两个以上的横向支撑结构和若干纵向支撑结构,每一所述横向支撑结构均由一金属丝弯曲形成环形支架,相邻两所述环形支架之间通过若干交错设置的所述纵向支撑结构固定连接,使支架撑开后形成网状结构,所述肾动脉支架由等长的两节支架构成,每节所述支架的一端均与一所述集成电路输出端连接,每节所述支架的另一端分别设置有绝缘材料。 [0008] Further, the renal artery stent comprises two or more lateral support structure and a plurality of longitudinal support structure, each of said lateral support structure is formed by bending a metal wire ring-shaped holder, between the two adjacent annular holder said longitudinal support structure by a plurality of staggered arranged fixedly connected to form a network structure of the stent after the expansion, the renal artery is constituted by two holder brackets of equal length, one end of each section are integrated with the holder a output of the circuit, and the other end of each section of the bracket are respectively provided with an insulating material.

[0009] 进一步,所述环形支架采用正弦波结构或锯齿波结构。 [0009] Further, the annular stent using a sine wave or a sawtooth structure.

[0010] 进一步,所述肾动脉支架作为天线的谐振频率f设置为: [0010] Further, the renal artery stent as the resonant frequency f of the antenna is set to:

Figure CN105832318AD00041

[0012]式中,N为环形支架的数量、η为环形支架中波形的起伏数量、1为纵向支撑结构的长度、Cl、C2和C3均为正系数。 [0012] In the formula, N is the number of annular support, [eta] is the number of undulating annular support of the waveform, 1 is the length of the longitudinal support structure, Cl, C2 and C3 are positive coefficients.

[0013] 进一步,两所述集成电路设置在一长条形结构上,长条形集成电路沿所述肾动脉支架轴向布置。 [0013] Further, the integrated circuit provided on a two elongated structures, the elongated integrated circuit disposed axially along the renal artery stent.

[0014] 进一步,每一所述集成电路均采用分段式结构,分段式集成电路沿肾动脉支架轴向布置。 [0014] Further, each of the integrated circuit sub-structure are used, the integrated circuit segmented axially along the renal artery stent deployment.

[0015] 进一步,每一所述集成电路均采用方形结构,包裹在其外部的生物可兼容性外壳采用圆形结构。 [0015] Further, each of the integrated circuit with a square configuration are wrapped using a circular structure outside thereof are biocompatible housing.

[0016] 进一步,每一所述集成电路均采用环形结构,环形集成电路所在平面与所述肾动脉支架的切面平行。 [0016] Further, each of the integrated circuit are used annular structure, the annular section and the plane of the integrated circuit to the renal artery stent parallel.

[0017] -种基于所述压强差监测装置的监测方法,其特征在于,包括以下内容:1)设置一包括有压力传感器、数据处理器、第一射频收发模块和外部处理设备的压强差监测装置,其中,外部处理设备包括接收天线、第二射频收发模块、处理器、传输模块和工作站;2)两个压力传感器分别采集肾动脉支架血管两端的血压信号,并分别通过相应数据处理器处理后传输至第一射频收发模块,两第一射频收发模块对接收的血压信号分别进行调制后通过天线发送到外部处理设备;3)接收天线将接收到的肾动脉支架血管两端的血压信号经第二射频收发模块进行解调后并经处理器处理后发送到工作站。 [0017] - monitoring method based on the kinds of pressure differential monitoring device, comprising the following: 1) is provided with a differential pressure monitor comprises a pressure sensor, a data processor, a first RF transceiver module and an external processing device apparatus, wherein the external processing apparatus includes a receiving antenna, a second RF transceiver module, a processor, workstation, and a transmission module; 2) were collected from the two pressure sensors blood pressure signal across the renal artery stent graft, and through each respective data processor after the transmission is transmitted to the first RF transceiver module, a first RF transceiver module of the two blood pressure signal received by the antenna are modulated to an external processing apparatus; 3) receive antennas the received signal of renal artery blood vessel stent ends after two and demodulates RF transceiver module transmits to the processor after the workstation.

[0018] 本发明由于采取以上技术方案,其具有以下优点:1、本发明包括肾动脉支架、两集成电路和外部处理设备,两集成电路分别固定设置在肾动脉支架血管的入口和出口处对肾动脉支架两端的动脉内血压进行监测,可以获得肾动脉内局部血压情况,通过肾动脉支架血管两端的压强差能够有效地对肾动脉支架的工作状态进行监测。 [0018] As a result of the present invention, the above technical solution, which has the following advantages: 1, the present invention comprises a renal artery stents, two external processing devices and integrated circuits, two integrated circuits provided respectively fixed to the inlet and the outlet of the renal artery stent graft arterial blood pressure across the monitor renal artery stent, local blood pressure can be obtained within the renal artery, by the pressure difference across the renal artery stent graft can be effectively operating state monitoring renal artery stenting. 2、本发明由于采取实时检测的方式,病人无需去医院做造影即可了解自身健康状况,降低了成本和风险,减少了患者的痛苦,使医生得到的反馈更加快速有效。 2, due to the present invention take the form of real-time detection, the patient need not go to the hospital for angiography to understand their own health status, reducing the cost and risk, reduce the suffering of patients, the doctors get feedback more quickly and efficiently. 3、本发明可以在手术治疗植入支架的同时植入集成电路,避免病人二次手术的痛苦。 3, the present invention may be implanted in an integrated circuit while the stent implantation surgery, the patient to avoid a second surgery pain. 本发明可以广泛应用于肾动脉疾病的状态监测中。 The present invention can be widely applied to the renal artery disease status monitoring.

附图说明 BRIEF DESCRIPTION

[0019] 图1是本发明的集成电路结构示意图; [0019] FIG. 1 is a schematic view of an integrated circuit structure according to the present invention;

[0020] 图2是本发明的数据处理器采用NRF51822芯片时的结构示意图; [0020] FIG. 2 is a schematic structural view of the present invention, the data processor chip NRF51822 employed;

[0021 ]图3是本发明的外部处理设备结构示意图; [0021] FIG. 3 is a schematic view of an external processing device structure of the present invention;

[0022] 图4是本发明肾动脉支架采用锯齿波形状结构示意图。 [0022] FIG. 4 is a schematic view of a sawtooth-shaped structure of the present invention employs the renal artery stenting.

具体实施方式 Detailed ways

[0023] 以下结合附图来对本发明进行详细的描绘。 [0023] The present invention reference to the following detailed depiction binding. 然而应当理解,附图的提供仅为了更好地理解本发明,它们不应该理解成对本发明的限制。 However, it should be understood that the drawings only provide a better understanding of the present invention, they should not be construed as limiting the present invention.

[0024] 如图1所示,本发明的基于肾动脉支架的压强差监测装置,包括一肾动脉支架、两集成电路和一外部处理设备;肾动脉支架作为天线用于进行能量和信号传输,两集成电路分别固定设置在肾动脉支架血管的入口和出口处,每一集成电路均包括一能量供应模块、 一压力传感器、一存储器、一数据处理器和一第一射频收发模块。 [0024] As shown, the differential pressure monitoring device 1 of the present invention based on the renal artery stenting, renal artery stenting comprising a two integrated circuits and an external processing device; renal Stent as an antenna for the energy and signal transmission, fixing two integrated circuits provided respectively at the inlet and outlet of the renal artery stent graft, each integrated circuit includes a power supply module, a pressure sensor, a memory, a data processor and a first RF transceiver module. 每一能量供应模块经作为天线的肾动脉支架通过第一射频收发模块接收由外部处理设备辐射至体内的电磁波,通过无线射频能量收集的方式为集成电路上其他部件供电。 Each power supply module is used as an antenna to receive radiation renal artery stent through a first RF transceiver module by the external processing device to an electromagnetic wave in the body, by way of radio frequency energy collected for other components on the integrated circuit power. 压力传感器将检测到的血压信号传输至存储器进行存储,数据处理器可从存储器读取数据,将其转化为数字信号,并加载集成电路ID、时间戳等信息,通过第一射频收发模块将数字信号经作为肾动脉支架的天线传输到外部处理设备,完成数据测量、信号发射功能。 The blood pressure sensor transmitting detected signals to a memory for storage, the data processor can read data from the memory, it converted to a digital signal, and load the integrated circuit ID, time stamp information, by a first digital RF transceiver module signal via the transmission antenna as the renal artery stent to external processing apparatus, data measurement is completed, the signal transmitting function. 其中,能量供应模块还可以采用微型电池作为替代,以便直接为集成电路上的各部件供电。 Wherein the energy supply module miniature batteries may also be employed as an alternative to directly power the components on the integrated circuit.

[0025] 在一个优选的实施例中,如图2所示,数据处理器可以采用是NORDIC公司生产的NRF51822芯片。 [0025] In a preferred embodiment, shown in Figure 2, the data processor may be employed NORDIC produced NRF51822 chip. 该芯片ADC转换引脚J6并联连接两压力传感器,VDD电源引脚J1连接能量供应模块,XC1、XC2引脚J37-J38连接时钟电路,¥00_?厶^犯1^阶2引脚130-132连接第一射频收发模块,P0.01引脚J5连接电源检测电路,DEC1引脚J39经第三电容C3接地;VSS引脚J33、 J34并联后接地,VSS引脚J33、J34并联后连接能量供应模块,位于AVDD引脚与VSS引脚之间并联第四电容C4』EC2引脚J29经第十电容C10与EXP_GND引脚J49连接后接地;VSS引脚J13 接地,SWCLK引脚经第三电阻R3接地。 The ADC conversion chip pin J6 two pressure sensors are connected in parallel, VDD supply pin connector J1 energy supply module, XC1, XC2 pin connector J37-J38 clock circuit, ¥ 00_? 1 ^ Si ^ commit order 2 pins 130-132 connecting a first RF transceiver module, P0.01 power detection circuit connected to the pin J5, DEC1 J39 pin grounded via the third capacitor C3; the VSS pins J33, J34 after parallel ground, VSS functions J33, J34 are connected in parallel after the energy supply module, located between the VSS pin AVDD pin parallel with the fourth capacitor C4 "EC2 J29 pin grounded EXP_GND tenth capacitor C10 is connected via pin J49; J13 ground VSS pin, pin via a third resistor R3 SWCLK ground.

[0026]其中,时钟电路包括第一电容C1、第二电容C2和晶振X1,晶振X1控制端管脚1经第二电容C 2接地,晶振X1输出端管脚2经第一电容C1接地;晶振X1控制端管脚1还连接至NRF51822芯片的XC1引脚J37,晶振XI输出端管脚2还连接至NRF51822芯片的XC2引脚J38。 [0026] wherein the clock circuit includes a first capacitor C1, a second capacitor C2 and the crystal X1, Crystal, X1 pin 1 via the control terminal of the second capacitor C 2 is grounded, the output of the crystal X1 pin 2 is grounded through a first capacitor a C1; crystal X1 pin 1 is also connected to the control terminal of the chip to NRF51822 XC1 pin J37, XI oscillator output terminal pin 2 is also connected to pin J38 NRF51822 XC2 chip. [0027] 电源检测电路包括第一电阻R1、第二电阻R2和电容C13,第一电阻R1-端接高电平(即能量供应模块),第一电阻R1另一端经第二电阻R2接地;位于第二电阻R2两端并联电容C13,且第一电阻R1另一端与第二电阻R2之间通过导线连接至NRF51822芯片的P0.01引脚J5。 [0027] The power detection circuit includes a first resistor R1, second resistor R2 and the capacitor C13, the first termination resistor R1- high (i.e., energy supply module), the other end of the first resistor R1 is grounded via a second resistor R2; a second resistor R2 positioned in parallel at both ends of the capacitor C13, and between the other end of the first resistor R1 and second resistor R2 is connected to the pin J5 NRF51822 P0.01 chip via a wire.

[0028]在一个优选的实施例中,如图3所示,外部处理设备包括发射天线、接收天线、第二射频收发模块、处理器、传输模块和工作站。 [0028] In a preferred embodiment, as shown, the external processing apparatus comprises a transmitting antenna, a receiving antenna, a second RF transceiver module, a processor, a workstation 3 and the transmission module. 由第二射频收发模块经发射天线向体内的集成电路发射电磁波传输能量,同时并经接收天线接收体内的集成电路发向体外的血压信号; 第二射频收发模块将接收到的血压信号经处理器、传输模块发送至工作站,以备后续使用。 Transmitted by a second RF transceiver module to the integrated circuit via the transmit antennas transmit the electromagnetic energy in the body, while the integrated circuit and receives signals sent to the blood in vitro in vivo via the receiving antenna; a second RF transceiver module received blood pressure signal processor , the transmission module transmits to the station, for subsequent use. 其中,工作站可以采用智能手机、智能手表等移动终端。 Wherein the workstation can smart phones, smart watch other mobile terminal.

[0029]在一个优选的实施例中,工作站内设置有信号处理系统,信号处理系统计算安装有肾动脉支架的血管两端的压强差,并判断在预设时间内获取的压强差是否在预设范围内,从而判断安装有肾动脉支架的血管是否出现了再狭窄的现象。 [0029] In a preferred embodiment, the station is provided with a signal processing system, signal processing system calculates the pressure difference across the mounting renal artery vascular stents, and determines whether the pressure difference obtained within a preset time preset the range in order to determine the installation renal artery stent restenosis vascular whether there has been a phenomenon.

[0030] 在一个优选的实施例中,如图4所示,肾动脉支架包括两个以上的横向支撑结构1 和若干纵向支撑结构2,每一横向支撑结构1均由一金属丝弯曲形成环形支架;相邻两环形支架之间通过若干交错设置的纵向支撑结构2固定连接,使支架撑开后形成网状结构。 [0030] In a preferred embodiment, shown in Figure 4, comprises more than two renal artery stent structure a plurality of lateral support and longitudinal support structure 2, each lateral support structure 1 is formed by bending a metal wire loop stent; staggered longitudinal support structure 2 is connected by a plurality of fixed annular support between two adjacent mesh structure is formed after the stent distraction. 环形支架可以采用正弦波结构或锯齿波结构。 A sine wave or a sawtooth annular support structure may be employed. 肾动脉支架由等长的两节支架构成,每节支架的一端均与一集成电路输出端连接,由两节支架构成集成电路天线的两极进行馈电。 Renal Stent composed of two stents of equal length, one end of each brace are connected to an output terminal of the integrated circuit, the two poles of an integrated circuit constituting the antenna holder is fed. 其中,在每节支架的另一端分别设置有绝缘材料,通过绝缘材料固定该节支架结构的稳固性。 Wherein the other end of each brace are provided with an insulating material, the stability of the brace fixed structure by an insulating material. 在本实施例中,该肾动脉支架作为天线时,其辐射性能更好,频带更宽。 In the present embodiment, the renal artery is used as an antenna bracket, better radiation performance, a wider frequency band.

[0031] 肾动脉支架作为天线的谐振频率f设置为: [0031] As the renal artery stent resonant frequency f of the antenna is set to:

Figure CN105832318AD00061

[0033]式中,N为环形支架的数量、η为环形支架中波形的起伏数量、1为纵向支撑结构的长度、ChCdPCs均为正系数。 [0033] In the formula, N is the number of annular support, [eta] is the number of undulating annular support of the waveform, 1 is the length of the longitudinal support structure, ChCdPCs are positive coefficients. 其中,Ν、η和1越大,谐振频率越小。 Wherein, Ν, η 1, and the larger, the smaller the resonance frequency. 使用时,由于不能调整肾动脉支架的尺寸,所以通过调整环形支架的数量Ν、环形支架中波形的起伏数量η以及纵向支撑结构的长度1来调整天线的谐振频率。 In use, since the renal artery stent can not be resized, so that by adjusting the number of the annular support Ν, η annular support undulating waveform number and the length of a longitudinal support structure to adjust the antenna resonant frequency.

[0034] 在一个优选的实施例中,每一集成电路外部包裹有生物可兼容性外壳。 [0034] In a preferred embodiment, each of the integrated circuit is wrapped with the outer shell are biocompatible. 每一集成电路可以通过一固定栓固定在肾动脉支架外侧,固定栓的一端焊接在集成电路的焊盘上, 另一端与肾动脉支架外壁连接在一起;固定栓暴露在生物可兼容性外壳外面,生物可兼容性外壳能避免产生人体的排异反应。 Each integrated circuit may be fixed by a pin fixed to the outside of the renal artery stent, an end of the bolt fixed by welding on the pads of the integrated circuit, the other end of the outer wall of the renal artery stents connected together; fixed bolt exposed outside the housing are biocompatible , are biocompatible casing can avoid rejection of the human body. 优选的,生物可兼容性外壳有一定柔韧性,可以弯曲。 Preferably, the bio-compatible housing may have a certain flexibility, may be bent. 生物可兼容性外壳的材料优选采用聚二甲基硅氧烷(PDMS)。 Are biocompatible housing material is preferably used polydimethylsiloxane (PDMS). 制作时,可将集成电路放在模具中,用聚二甲基硅氧烷进行填充封装,把固定栓留在外面从而制备出带生物可兼容性外壳和固定栓的集成电路。 Production, an integrated circuit may be placed in a mold, the package is filled with polydimethylsiloxane, the fixed bolt to prepare a stay outside the integrated circuit and the housing are biocompatible with the fixed bolt.

[0035] 在一个优选的实施例中,固定栓和肾动脉支架的焊点处还可以覆盖有生物可兼容性药膜。 [0035] In a preferred embodiment, the solder plug at a fixed bracket and renal arteries may also be covered with a membrane in the biological compatibility. 由于固定栓和肾动脉支架的焊接可能会破坏肾动脉支架外面的生物可兼容性外壳,在固定栓和肾动脉支架焊接处覆盖一层药膜,可进一步防止人体的排异反应发生。 Since the fixing pin and renal artery stent welding may break out renal artery stents are biocompatible housing, the stationary pin covered with pellicles renal artery and welding the bracket, the body can be further prevented rejection occurs.

[0036] 在一个优选的实施例中,每一集成电路均由柔性电路板和形成在该柔性电路板上由晶圆制成的各模块电路芯片制成,以适应体积限制,并能随肾动脉支架形状的变化进行弯曲,但是其长度不超过肾动脉支架长度,且为了不堵塞血管,其截面积不超过〇.5mmX 0.5mm〇 [0036] In a preferred embodiment, each integrated circuit is formed by a flexible circuit board and the circuit chip on each module of the flexible circuit board made by the wafer is made to accommodate the volume constraints, and with the kidney can changes in arterial stent shape bending, but not longer than the length of the renal artery stenting, and in order not to block blood vessels, its cross-sectional area does not exceed 〇.5mmX 0.5mm〇

[0037] 在一个优选的实施例中,两集成电路可以设置在一长条形结构上,长条形集成电路沿肾动脉支架轴向布置;每一集成电路均可以采用分段式结构,分段式集成电路沿肾动脉支架轴向布置,集成电路外部包裹有生物可兼容性外壳;每一集成电路均可以采用方形结构,包裹在其外部的生物可兼容性外壳采用圆形结构;每一集成电路均可以采用环形结构,环形集成电路所在平面与肾动脉支架的切面平行。 [0037] In a preferred embodiment, two integrated circuit may be disposed on an elongated structure, an integrated circuit arranged in the elongated axially renal artery stent; are each an integrated circuit sub-structure may be employed, divided the integrated circuit stage renal stent arranged axially along the outer package housing the integrated circuit there are biocompatible; each integrated circuit structure can be a square, circular structure employed in wrapping the outside thereof are biocompatible housing; each the integrated circuit can be employed annular structure, the integrated circuit is located and an annular flat section parallel to renal artery stents.

[0038] 下面通过具体实施例详细说明采用本发明的基于肾动脉支架的压强差监测装置对患者的血压进行监测的具体过程: [0038] The specific procedure will be described below based on the differential pressure monitoring means monitoring the blood pressure of renal artery stent patients present invention in detail by way of specific embodiments:

[0039] 1、两个压力传感器分别采集肾动脉支架血管两端的血压信号,并分别通过相应数据处理器处理后传输至第一射频收发模块,两第一射频收发模块对接收的血压信号分别进行调制后通过天线发送到外部处理设备。 [0039] 1, two pressure sensors were collected from blood pressure signal across the renal artery stent graft, and through the corresponding data are transmitted to the processor a first RF transceiver module, a first RF transceiver module of the two blood pressure signals are received modulated transmission through the antenna to an external processing device.

[0040] 2、接收天线将接收到的肾动脉支架血管两端的血压信号经射频收发模块进行解调后,并经处理器处理后发送到工作站。 [0040] 2, the receiving antenna will receive the blood pressure signal across the renal artery stent graft after demodulating the RF transceiver module, and sent to the workstation by the processor.

[0041] 在具体实施例中,采用本发明的基于肾动脉支架的压强差监测装置对肾动脉支架工作状态进行检测的过程: [0041] In one embodiment, the process based on the differential pressure detection means monitoring renal artery stent renal artery stent operating state of the specific embodiment of the present invention:

[0042]设置在工作站内的信号处理系统将接收的安装有肾动脉支架的血管两端的压强差与预设值进行比较,如果在设定时间内肾动脉支架血管两端的压强差处于预设范围内, 确定肾动脉支架工作状态良好,认为安装有肾动脉支架的血管没有发生再狭窄现象;如果在设定时间内肾动脉支架血管两端的压强差不在预设范围内,确定肾动脉支架工作状态出现异常,认为安装有肾动脉支架的血管发生再狭窄现象。 [0042] The signal processing system provided in a station attached to the received value with a preset pressure differential across the renal artery vascular stents compares a preset range if the pressure difference at both ends of the renal artery stent graft within the set time in the determining renal stent good working condition, that is attached to the renal artery stent restenosis has not occurred; the renal arteries if the pressure at both ends of the stent graft within the set time difference is not within the predetermined range, the working state determining renal artery stenting abnormal that the installation renal artery vascular stent restenosis phenomenon. 另外,可以根据获取的肾动脉支架血管两端的压强差作为参考值进一步了解肾动脉支架的工作情况。 Further, as a reference value for further understanding of the operation of the stent according to the renal artery pressure difference across the renal artery stent graft acquired.

[0043]上述各实施例仅用于说明本发明,其中各部件的结构、连接方式和制作工艺等都是可以有所变化的,凡是在本发明技术方案的基础上进行的等同变换和改进,均不应排除在本发明的保护范围之外。 [0043] The above-described embodiments are merely illustrative of the invention, wherein the structure and production process of each connection member and the like can all be varied, equivalents, changes and modifications usually made on the basis of the technical solution of the present invention, should not be excluded from the scope of the present invention.

Claims (10)

1. 一种基于肾动脉支架的压强差监测装置,其特征在于,该监测装置包括一肾动脉支架、两集成电路和一外部处理设备; 所述肾动脉支架作为天线使用,两所述集成电路分别固定设置在所述肾动脉支架的血管的入口和出口处;每一所述集成电路均包括一能量供应模块、一压力传感器、一存储器、 一数据处理器和一第一射频收发模块,每一所述能量供应模块用于为所述集成电路供电; 所述压力传感器将检测到的血压信号经所述存储器传输至所述数据处理器,所述数据处理器将血压信号转化为数字信号,并通过所述第一射频收发模块将数字信号经所述肾动脉支架传输到所述外部处理设备。 A differential pressure monitoring means based on renal artery stenting, characterized in that the monitoring device comprises a renal artery stenting, two integrated circuits and an external processing device; the renal artery stent used as an antenna, the two IC are respectively fixedly provided at the inlet and outlet of the renal artery vascular stents; each of said integrated circuit comprises a power supply module, a pressure sensor, a memory, a data processor and a first RF transceiver module, each a means for the energy supply to the integrated circuit power supply; the pressure sensor detects the blood pressure signal is transmitted to the memory of the data processor, the data processor blood pressure signal into a digital signal, and the digital signal transmitted via the renal artery stent to said external processing apparatus via said first RF transceiver module.
2. 如权利要求1所述的基于肾动脉支架的压强差监测装置,其特征在于,所述外部处理设备包括发射天线、接收天线、第二射频收发模块、处理器、传输模块和工作站,由所述第二射频收发模块经所述发射天线向体内的所述集成电路发射电磁波传输能量,同时经所述接收天线接收体内所述集成电路发向体外的血压信号,所述射频收发模块将接收到的血压信号经所述处理器和传输模块发送至所述工作站。 2. The differential pressure monitoring means based on renal Stent according to claim 1, wherein said external processing apparatus comprises a transmitting antenna, a receiving antenna, a second RF transceiver module, a processor, a workstation, and a transmission module, a the RF transceiver module via the second transmit antennas transmit the electromagnetic energy to the body of the integrated circuit, while the receiving antennas through the body of the blood pressure signal sent to the integrated circuit in vitro, the received RF transceiver module blood pressure signals to the processor module and sent to the transmitting station.
3. 如权利要求1所述的基于肾动脉支架的压强差监测装置,其特征在于,所述肾动脉支架包括两个W上的横向支撑结构和若干纵向支撑结构,每一所述横向支撑结构均由一金属丝弯曲形成环形支架,相邻两所述环形支架之间通过若干交错设置的所述纵向支撑结构固定连接,使支架撑开后形成网状结构,所述肾动脉支架由等长的两节支架构成,每节所述支架的一端均与一所述集成电路输出端连接,每节所述支架的另一端分别设置有绝缘材料。 3. The apparatus as claimed in pressure difference based on the monitoring of the renal artery stent 1, each of said lateral support structure, characterized in that said bracket comprises a renal artery on both lateral support structure and a plurality of longitudinal support structure W, is formed by a curved annular support wire, is fixedly connected adjacent the longitudinal support structure by a plurality of staggered arranged between said two ring-shaped holder, the holder forms a network structure after the expansion, the stent is formed as long as the renal artery composed of two brackets, one end of each of said stent sections are connected to the output terminal of an integrated circuit, the other end of each section of the bracket are respectively provided with an insulating material.
4. 如权利要求3所述的基于肾动脉支架的压强差监测装置,其特征在于,所述环形支架采用正弦波结构或银齿波结构。 4. The differential pressure monitoring means based on renal Stent according to claim 3, characterized in that the annular stent using a sine wave or silver tooth wave structure.
5. 如权利要求3或4所述的基于肾动脉支架的压强差监测装置,其特征在于,所述肾动脉支架作为天线的谐振频率f设置为: 5. The differential pressure monitoring means renal artery stent of claim 3 or 4 based on claim, wherein said stent renal artery as the resonance frequency f of the antenna is:
Figure CN105832318AC00021
式中,N为环形支架的数量、η为环形支架中波形的起伏数量、1为纵向支撑结构的长度、 Cl、C2和C3均为正系数。 Where, N is the number of annular support, [eta] is the number of undulating annular support of the waveform, 1 is the length of the longitudinal support structure, Cl, C2 and C3 are positive coefficients.
6. 如权利要求1或2或3或4所述的基于肾动脉支架的压强差监测装置,其特征在于,两所述集成电路设置在一长条形结构上,长条形集成电路沿所述肾动脉支架轴向布置。 6. The differential pressure monitoring means based on renal artery stent 1 or 2 or 3 or claim 4, characterized in that the two integrated circuits disposed on an elongated structure, the elongated along the IC said axially disposed renal artery stents.
7. 如权利要求1或2或3或4所述的基于肾动脉支架的压强差监测装置,其特征在于,每一所述集成电路均采用分段式结构,分段式集成电路沿肾动脉支架轴向布置。 7. The differential pressure monitoring means based on renal artery stent 1 or 2 or 3 or claim 4, wherein each of said integrated circuit structure are made of segmented, segmented along the renal artery IC stand axially disposed.
8. 如权利要求1或2或3或4所述的基于肾动脉支架的压强差监测装置,其特征在于,每一所述集成电路均采用方形结构,包裹在其外部的生物可兼容性外壳采用圆形结构。 8. The differential pressure monitoring means based on renal artery stent 1 or 2 or 3 or claim 4, wherein each of said square integrated circuit structure are used, wrapping are biocompatible housing outside thereof with circular configuration.
9. 如权利要求1或2或3或4所述的基于肾动脉支架的压强差监测装置,其特征在于,每一所述集成电路均采用环形结构,环形集成电路所在平面与所述肾动脉支架的切面平行。 9. The differential pressure monitoring means based on renal artery stent 1 or 2 or 3 or claim 4, wherein each of said integrated circuit are used annular structure, the annular plane of the integrated circuit and the renal artery cut parallel to the stent.
10. -种基于如权利要求1~9任一项所述压强差监测装置的监测方法,其特征在于,包括W下内容: 1)设置一包括有压力传感器、数据处理器、第一射频收发模块和外部处理设备的压强差监测装置,其中,外部处理设备包括接收天线、第二射频收发模块、处理器、传输模块和工作站; 2) 两个压力传感器分别采集肾动脉支架血管两端的血压信号,并分别通过相应数据处理器处理后传输至第一射频收发模块,两第一射频收发模块对接收的血压信号分别进行调制后通过天线发送到外部处理设备; 3) 接收天线将接收到的肾动脉支架血管两端的血压信号经第二射频收发模块进行解调后并经处理器处理后发送到工作站。 10. - The method of monitoring the pressure differential based on kinds of monitoring apparatus of claims 1 to 9 as one of the preceding claims, characterized in that it comprises contents W: 1) is provided comprising a pressure sensor, a data processor, the first RF transceiver pressure differential monitoring device module and an external processing device, wherein the external processing apparatus includes a receiving antenna, a second RF transceiver module, a processor, workstation, and a transmission module; 2) were collected from the two pressure sensors blood pressure signal across the renal artery stent graft after the transmission, and a first RF transceiver module are two blood pressure received signal modulated by the data processor corresponding to the first transmitted RF transceiver module, respectively, to an external processing apparatus through the antenna; 3) receive antennas the received kidney after the arterial blood pressure signal across a second stent graft is demodulated by RF transceiver module after the workstation and sent to the processor.
CN201610392986.0A 2016-06-06 2016-06-06 Renal arterial stent based pressure difference monitoring device and renal arterial stent based pressure difference monitoring method CN105832318A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610392986.0A CN105832318A (en) 2016-06-06 2016-06-06 Renal arterial stent based pressure difference monitoring device and renal arterial stent based pressure difference monitoring method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610392986.0A CN105832318A (en) 2016-06-06 2016-06-06 Renal arterial stent based pressure difference monitoring device and renal arterial stent based pressure difference monitoring method

Publications (1)

Publication Number Publication Date
CN105832318A true CN105832318A (en) 2016-08-10

Family

ID=56576433

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610392986.0A CN105832318A (en) 2016-06-06 2016-06-06 Renal arterial stent based pressure difference monitoring device and renal arterial stent based pressure difference monitoring method

Country Status (1)

Country Link
CN (1) CN105832318A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5967986A (en) * 1997-11-25 1999-10-19 Vascusense, Inc. Endoluminal implant with fluid flow sensing capability
CN104382676A (en) * 2014-11-21 2015-03-04 清华大学深圳研究生院 In-vivo wireless communication device based on vascular stent and wireless communication system
WO2015068167A2 (en) * 2013-11-06 2015-05-14 Enopace Biomedical Ltd. Wireless endovascular stent-based electrodes
CN105193529A (en) * 2015-10-20 2015-12-30 清华大学深圳研究生院 In vivo wireless sensing system based on cardiovascular stent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5967986A (en) * 1997-11-25 1999-10-19 Vascusense, Inc. Endoluminal implant with fluid flow sensing capability
WO2015068167A2 (en) * 2013-11-06 2015-05-14 Enopace Biomedical Ltd. Wireless endovascular stent-based electrodes
CN104382676A (en) * 2014-11-21 2015-03-04 清华大学深圳研究生院 In-vivo wireless communication device based on vascular stent and wireless communication system
CN105193529A (en) * 2015-10-20 2015-12-30 清华大学深圳研究生院 In vivo wireless sensing system based on cardiovascular stent

Similar Documents

Publication Publication Date Title
Bashirullah Wireless implants
US8382677B2 (en) Anchored implantable pressure monitor
Panescu Emerging technologies [wireless communication systems for implantable medical devices]
JP4845964B2 (en) mri resonator system with a stent-graft
US8615284B2 (en) Method for acoustic information exchange involving an ingestible low power capsule
AU2002357055B2 (en) Apparatus and method for monitoring a condition inside a body cavity
ES2232412T3 (en) BIOTELEMETRY passive.
US5394882A (en) Physiological monitoring system
US8475374B2 (en) Intra-occular pressure sensor
US8489199B2 (en) Bio-medical unit with power harvesting module and RF communication
EP0984742B1 (en) Stents for blood vessels
US9265428B2 (en) Implantable wireless sensor
US6475170B1 (en) Acoustic biosensor for monitoring physiological conditions in a body implantation site
US8588887B2 (en) Ingestible low power sensor device and system for communicating with same
Hao et al. Wireless body sensor networks for health-monitoring applications
KR101006650B1 (en) Telemetric strain sensing system
AU2011200363B2 (en) Coupling loop and method for positioning coupling loop
US6486588B2 (en) Acoustic biosensor for monitoring physiological conditions in a body implantation site
JP5763342B2 (en) Adhesive patch for measuring acoustic signals
US8412352B2 (en) Communication dipole for implantable medical device
US10205227B2 (en) Antenna device
CN1289160C (en) Stent
US20100161004A1 (en) Wireless dynamic power control of an implantable sensing device and methods therefor
Ullah et al. A review of wireless body area networks for medical applications
JP5567723B2 (en) Data collection system in two of the wrist

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination