CN105919558A - Multi-modal imaging system and method based on structure imaging and functional imaging - Google Patents
Multi-modal imaging system and method based on structure imaging and functional imaging Download PDFInfo
- Publication number
- CN105919558A CN105919558A CN201610349251.XA CN201610349251A CN105919558A CN 105919558 A CN105919558 A CN 105919558A CN 201610349251 A CN201610349251 A CN 201610349251A CN 105919558 A CN105919558 A CN 105919558A
- Authority
- CN
- China
- Prior art keywords
- imaging
- imaged
- biological sample
- pet
- functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/032—Transmission computed tomography [CT]
- A61B6/035—Mechanical aspects of CT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/037—Emission tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/10—Application or adaptation of safety means
- A61B6/107—Protection against radiation, e.g. shielding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/44—Constructional features of apparatus for radiation diagnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
- A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
- A61B6/5247—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/54—Control of apparatus or devices for radiation diagnosis
Abstract
The invention provides a multi-modal imaging system and method based on structure imaging and functional imaging. The multi-modal imaging system based on the structure imaging and the functional imaging comprises a CT (computed tomography) imaging device, an even number of PET (position emission tomography) imaging devices, an SPECT (single photon emission computed tomography) imaging device, a photoacoustic imaging device, a rotating device and a control device, wherein accommodating space for accommodating to-be-imaged biological samples is formed by means of the rotating device, and the rotating device can rotate relative to the to-be-imaged biological samples; the CT imaging device, an even number of PET imaging devices and the photoacoustic imaging device surround the accommodating space, are arranged on the rotating device at intervals and are electrically connected with the control device; an even number of PET imaging devices are symmetrically arranged relative to the to-be-imaged biological samples. The multi-modal imaging system solves the problem that multiple unimodal technologies cannot be combined in time and space to form medical imaging technologies with complementary advantages in the prior art.
Description
Technical field
The present invention relates to medical imaging technology field, in particular it relates to one becomes with function based on structure imaging
The multi-mode imaging system of picture and formation method thereof.
Background technology
Information acquired in conventional single-mode state imaging has some limitations, it is impossible to reflect organism completely
Complicated specificity.Although the CT imaging device density resolution of single mode is higher, using the teaching of the invention it is possible to provide anatomical structure
Information, but well soft tissue can not be carried out imaging；The MRI imaging device of single mode has the softest
Tissue resolution capability, using the teaching of the invention it is possible to provide Physiology and biochemistry information, but the display to bony structures is relatively poor；Single
The radio nuclide imaging device of mode has higher specificity, using the teaching of the invention it is possible to provide functional metabolism information, but this device
Involve great expense, and sensitivity and resolution relatively low；The PET imaging device of single mode and SPECT imaging
Device is not limited by investigation depth, image sensitivity high and is prone to quantitative, but spatial resolution is relatively low；
Single-mode optical imaging device is highly sensitive, "dead", specificity is good and low cost, using the teaching of the invention it is possible to provide cell
The physiological and pathological information of molecular level, but spatial resolution is relatively low, imaging depth is limited.Therefore, it can see
Going out derived techniques and be respectively arranged with pluses and minuses, single image mode is not provided that comprehensive and accurate information.
The biggest complementarity is had between different image modes.Such as, the positron of nuclear medicine molecular image is sent out
Penetrate the image that fault imaging (PET)/single photon emission tomographic imaging (SPECT) obtains and lack high-resolution three
Dimension anatomical information, needs the structural images ability relying on computer tomography (CT) to obtain the most accurate
Really provide complete organism physiology or pathological information for pre-clinic and clinical research；For dividing at bulk optics
For sub-image, if lacking the high-resolution three-dimension anatomical information that CT obtains, then cannot be accurate
Really characterize distribution and the strength information in organism internal light source region.
But, still cannot be by CT imaging technique, PET imaging technique and photoacoustic imaging technology in prior art
Combine to form the medical imaging techniques of mutual supplement with each other's advantages over time and space.
Summary of the invention
It is an object of the invention to provide a kind of multi-mode imaging system based on structure imaging and functional imaging and
Its formation method, it is intended to solving cannot by multiple single mode imaging techniques over time and space in prior art
The problem combining to form the medical imaging techniques of mutual supplement with each other's advantages.
For solving above-mentioned technical problem, the technical scheme is that a kind of multi-modality imaging of offer, including:
CT imaging device, even number PET imaging device, opto-acoustic imaging devices, rotary apparatus and control device,
Described rotary apparatus is formed for placing the receiving space of biological sample to be imaged, described rotary apparatus relative to
Described biological sample to be imaged is rotatable, PET imaging device described in described CT imaging device, even number with
And described opto-acoustic imaging devices around described receiving space and is spaced apart and arranged on described rotary apparatus, described
PET imaging device described in CT imaging device, even number and described opto-acoustic imaging devices respectively with described control
Device processed electrically connects, and wherein, PET imaging device described in even number is relative to described biological sample pair to be imaged
Claim to arrange.
Alternatively, described CT imaging device includes CT bulb and CT detector, described CT bulb and institute
State CT detector to be installed on described rotary apparatus, and described CT bulb is relative with described CT detector
Being symmetrical arranged in described biological sample to be imaged, wherein, described CT detector is electrically connected with described control device
Connect.
Alternatively, described opto-acoustic imaging devices includes ultrasonic transducer and laser instrument, and described ultrasonic transducer is pacified
Being contained on described rotary apparatus, described laser instrument is fixedly installed relative to described biological sample to be imaged, wherein,
Described ultrasonic transducer electrically connects with described controller.
Alternatively, the line between described biological sample to be imaged and described laser instrument is horizontal axis, described
Rotary apparatus turns in the perpendicular being perpendicular to described horizontal axis relative to described biological sample to be imaged
Dynamic.
Alternatively, the line between described biological sample to be imaged and described laser instrument is vertical axis, described
Rotary apparatus turns in the horizontal plane being perpendicular to described vertical axis relative to described biological sample to be imaged
Dynamic.
Alternatively, described multi-mode imaging system based on structure imaging Yu functional imaging also includes life to be imaged
Thing sample load bearing seat, this biological sample load bearing seat to be imaged is at described biological sample to be imaged and described laser instrument
Between the direction of line be movably disposed, and in carrying out imaging operation, be positioned at described receiving space
In.
Alternatively, described multi-mode imaging system based on structure imaging Yu functional imaging also includes protective shield of radiation
Covering cover, described rotary apparatus is arranged in described radiation-resistance mask, and described control device is positioned at described anti-spoke
Penetrate outside radome.
According to a further aspect in the invention, it is provided that a kind of based on structure imaging and functional imaging multi-modal become
Image space method, this multi-modality imaging method uses aforesaid multi-modality imaging based on structure imaging Yu functional imaging
System carries out imaging operation, and described multi-modality imaging method includes following operating procedure:
Step S10: based on structure imaging and functional imaging described in placement biological sample to be imaged is positioned over
In the receiving space that the rotary apparatus of multi-mode imaging system is formed；
Step S20: first open described PET based on structure imaging Yu the multi-mode imaging system of functional imaging
Imaging device gathers the PET scan data of described biological sample to be imaged, is then turned on described based on knot composition
As CT imaging device and opto-acoustic imaging devices with the multi-mode imaging system of functional imaging, and open described
Rotary apparatus based on structure imaging Yu the multi-mode imaging system of functional imaging make described CT imaging device and
Opto-acoustic imaging devices rotates around described biological sample to be imaged, to gather the CT of described biological sample to be imaged
Scan data and optical acoustic scanning data；
Step S30: described control device root based on structure imaging Yu the multi-mode imaging system of functional imaging
It is analyzed according to described PET scan data, described CT scan data and described optical acoustic scanning data and rebuilds
The three-dimensional multimode state image of described biological sample to be imaged.
Alternatively, in the imaging operation of described step S20, first move described PET imaging device and lean on
Nearly described biological sample to be imaged, to gather the PET scan data of described biological sample to be imaged, is gathering
After becoming described PET scan data, mobile described PET imaging device resets, and wherein, described PET imaging fills
Put and can move along the radial direction of described rotary apparatus.
Alternatively, in the imaging operation of described step S20, described PET imaging device is around described
Biological sample to be imaged constitutes closed area, sweeps gathering the PET of the full angle of described biological sample to be imaged
Retouch data；Or, described PET imaging device constitutes the envelope of predetermined angular around described biological sample to be imaged
Closed region, to gather the PET scan data of the limited angular of described biological sample to be imaged.
In the present invention, by CT imaging device, PET imaging device and opto-acoustic imaging devices at rotary apparatus
On treat Imaging biological samples in same time, the same space position and carry out respective imaging data information and carry out
Gathering, the three-dimensional rebuilding biological sample to be imaged after being analyzed the most uniformly processing in controlling device is many
Modality images.Therefore, it is somebody's turn to do application based on structure imaging Yu the multi-mode imaging system of functional imaging, it is possible to
Solve multiple single mode imaging techniques cannot be combined to form advantage by prior art over time and space
The problem of complementary medical imaging techniques.
Accompanying drawing explanation
Fig. 1 is the master based on structure imaging Yu the embodiment of the multi-mode imaging system of functional imaging of the present invention
TV structure schematic diagram；
Fig. 2 is the right TV structure schematic diagram of Fig. 1.
In the accompanying drawings:
11, CT bulb；12, CT detector；20, PET imaging device；
41, ultrasonic transducer；42, laser instrument；50, rotary apparatus；
60, biological sample to be imaged.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with accompanying drawing and reality
Execute example, the present invention is further elaborated.Only should be appreciated that specific embodiment described herein
Only in order to explain the present invention, it is not intended to limit the present invention.
It should be noted that when element is referred to as " being fixed on " or " being arranged at " another element, and it can
With directly on another element or be connected on this another element.When an element is referred to as " connecting
In " another element, it can be directly to another element or be indirectly connected to this another yuan
On part.
Also, it should be noted the orientation term such as left and right, upper and lower in the present embodiment, it it is only phase each other
To concept or with the normal operating condition of product as reference, and should not be regarded as restrictive.
As depicted in figs. 1 and 2, the multi-modality imaging system based on structure imaging Yu functional imaging of the present embodiment
System includes CT imaging device, even number PET imaging device 20, opto-acoustic imaging devices, rotary apparatus 50
And control device.Should be formed by rotary apparatus 50 based on structure imaging with the multi-mode imaging system of functional imaging
For placing the receiving space of biological sample 60 to be imaged, rotary apparatus 50 is relative to biological sample to be imaged
60 is rotatable, and CT imaging device, even number PET imaging device 20 and opto-acoustic imaging devices are around receiving
Space and being spaced apart and arranged on rotary apparatus 50, CT imaging device, even number PET imaging device 20
And opto-acoustic imaging devices electrically connects with control device respectively, wherein, even number PET imaging device 20 phase
Biological sample 60 to be imaged is symmetrical arranged.
By CT imaging device, PET imaging device 20 and opto-acoustic imaging devices on rotary apparatus 50
Same time, the same space position are treated Imaging biological samples 60 and are carried out respective imaging data information and adopt
Collection, the three-dimensional rebuilding biological sample 60 to be imaged after being analyzed the most uniformly processing in controlling device is many
Modality images.Therefore, it is somebody's turn to do application based on structure imaging Yu the multi-mode imaging system of functional imaging, it is possible to
Solve multiple single mode imaging techniques cannot be combined to form advantage by prior art over time and space
The problem of complementary medical imaging techniques, it is achieved that to function and divide from simple histoorgan morphology imaging
The development of sub-image.
In the present embodiment, CT imaging device includes CT bulb 11 and CT detector 12, CT bulb
11 are used for producing X-ray, treat Imaging biological samples 60 by X-ray and are irradiated, and CT detects
Device 12 is for collecting the X-ray signal after biological sample 60 to be imaged.CT bulb 11 and CT is visited
Survey device 12 to be respectively mounted on the spinning device, and CT bulb 11 and CT detector 12 is relative to life to be imaged
Thing sample 60 is symmetrical arranged, so that X-ray just can horse back quilt after irradiating biological sample 60 to be imaged
CT detector 12 is received and is carried out data message collection, and without arriving again after X-ray is changed
CT detector 12 and cause weakening of X-ray energy.Wherein, CT detector 12 is electrically connected with controlling device
Connecing, the X-ray signal collected is sent to control device and carries out the analysis of data message by CT detector 12
Process.
As in figure 2 it is shown, the opto-acoustic imaging devices of the present embodiment includes ultrasonic transducer 41 and laser instrument 42.
Laser instrument 42 is used for sending short-pulse laser to be treated Imaging biological samples 60 and is irradiated, thus produces corresponding
Ultrasound data information；Ultrasonic transducer is used for gathering short-pulse laser and acts on biological sample 60 to be imaged
The ultrasound wave sent, thus ultrasound wave is converted to the energy information data message as photoacoustic imaging.Super
Sonic transducer 41 is arranged on rotary apparatus 50, and laser instrument 42 is fixed relative to biological sample 60 to be imaged
Arranging, wherein, ultrasonic transducer 41 is electrically connected with the controller.
Specifically, the line between biological sample to be imaged 60 and the laser instrument 42 of the present embodiment is trunnion axis
Line, rotary apparatus 50 turns in the perpendicular being perpendicular to horizontal axis relative to biological sample 60 to be imaged
Dynamic, i.e. rotary apparatus 50 rotates in a counter-clockwise direction around biological sample 60 to be imaged in vertical plane.As
Shown in Fig. 2, setting up rectangular coordinate system in space xyz with laser instrument 42 for initial point, coordinate system x-axis is trunnion axis,
Coordinate system y-axis is vertical axes, and coordinate system z-axis is between biological sample 60 to be imaged and laser instrument 42
Line be horizontal axis, rotary apparatus 50 rotate perpendicular be parallel to the plane that x-axis y-axis determines,
Rotary apparatus 50 rotates around z-axis.
In the present embodiment, in order to convenient, stably place biological sample 60 to be imaged, therefore based on
Structure imaging also includes biological sample load bearing seat to be imaged with the multi-mode imaging system of functional imaging, and this is treated into
As the direction of biological sample load bearing seat line between biological sample 60 to be imaged and laser instrument 42 may move
Ground is arranged, and before placing biological sample 60 to be imaged, biological sample load bearing seat to be imaged is within accommodating space
Being moved along the z-axis direction, after placement completes biological sample 60 to be imaged, biological sample to be imaged holds
Carry seat to move into along the z-axis direction in receiving space together with biological sample 60 to be imaged, and carry out imaging
Always situated in accommodating in space in operating process.
Preferably due to this multi-mode imaging system based on structure imaging with functional imaging is being operated
The process of collection information, the personal safety of staff can be produced and damage by some radioactive rays, therefore,
Multi-mode imaging system based on structure imaging Yu functional imaging also includes radiation-resistance mask, this protective shield of radiation
It is horizontally disposed for covering cover, and rotary apparatus 50 is arranged in radiation-resistance mask, controls device and is positioned at radioprotective
Outside radome, thus protect staff not by the radiation damage of radioactive ray, it is ensured that the people of staff
Body is healthy.
In the embodiment that another is feasible, compared with above-described embodiment, there is following difference.Treat
Line between Imaging biological samples 60 and laser instrument 42 is vertical axis, and rotary apparatus 50 is relative to treating into
As biological sample 60 rotates in the horizontal plane being perpendicular to vertical axis.Now, rectangular coordinate system in space
The z-axis of xyz is vertical axes, and x-axis y-axis determines that a horizontal plane, rotary apparatus 50 rotate counterclockwise jointly
The plane-parallel that plane determines with x-axis y-axis, biological sample load bearing seat to be imaged is for be vertically arranged along z-axis
And z-axis direction moves up and down.In addition to above-mentioned difference, remaining structure is the most identical, does not repeats them here
According to a further aspect in the invention, it is provided that a kind of multi-modality imaging method.This multi-modality imaging method
Aforesaid multi-mode imaging system based on structure imaging Yu functional imaging is used to carry out imaging operation, multi-modal
Formation method includes following operating procedure:
Step S10: be positioned over based on structure imaging and functional imaging many by placing biological sample 60 to be imaged
In the receiving space that the rotary apparatus 50 of modality imaging system is formed, when need imaging to as if disease suffer from
During person, patient can lie low or stand on biological sample load bearing seat to be imaged, biological sample the most to be imaged
Load bearing seat is mobile as accommodated in space together with patient；
Step S20: first open PET imaging based on structure imaging Yu the multi-mode imaging system of functional imaging
Device 20 gathers the PET scan data of biological sample 60 to be imaged, is then turned on based on structure imaging and merit
The CT imaging device of the multi-mode imaging system of energy imaging and opto-acoustic imaging devices, and open based on knot composition
As the rotary apparatus 50 of the multi-mode imaging system with functional imaging makes CT imaging device and opto-acoustic imaging devices
Rotate around biological sample 60 to be imaged, to gather CT scan data and the light of biological sample 60 to be imaged
Sound scan data；
Step S30: control device based on structure imaging and the multi-mode imaging system of functional imaging according to
PET scan data, CT scan data and optical acoustic scanning data are analyzed and rebuild biological sample to be imaged
Three-dimensional multimode state image
Wherein, in the imaging operation of step S20 of this method, first move PET imaging device 20 and lean on
Nearly biological sample to be imaged 60, to gather the PET scan data of biological sample 60 to be imaged, completes in collection
After PET scan data, mobile PET imaging device 20 resets, and wherein, PET imaging device 20 can be along rotation
The radial direction of device 50 moves.
Additionally, in the imaging operation of step S20, PET imaging device 50 is around biology to be imaged
Sample 60 constitutes closed area, to gather the PET scan data of the full angle of biological sample 60 to be imaged；
Or, PET imaging device 50 constitutes the closed area of predetermined angular around biological sample 60 to be imaged, with
Gather the PET scan data of the limited angular of biological sample to be imaged.
In the present invention, even number PET imaging device 20 is preferably four.
These are only presently preferred embodiments of the present invention, not in order to limit the present invention, all the present invention's
Any amendment, equivalent and the improvement etc. made within spirit and principle, should be included in the guarantor of the present invention
Within the scope of protecting.
Claims (10)
1. a multi-mode imaging system based on structure imaging Yu functional imaging, it is characterised in that including:
CT imaging device, even number PET imaging device, opto-acoustic imaging devices, rotary apparatus and control device,
Described rotary apparatus is formed for placing the receiving space of biological sample to be imaged, described rotary apparatus relative to
Described biological sample to be imaged is rotatable, PET imaging device described in described CT imaging device, even number with
And described opto-acoustic imaging devices around described receiving space and is spaced apart and arranged on described rotary apparatus, described
PET imaging device described in CT imaging device, even number and described opto-acoustic imaging devices respectively with described control
Device processed electrically connects, and wherein, PET imaging device described in even number is relative to described biological sample pair to be imaged
Claim to arrange.
2. multi-mode imaging system based on structure imaging Yu functional imaging as claimed in claim 1, it is special
Levying and be, described CT imaging device includes CT bulb and CT detector, described CT bulb and described CT
Detector is installed on described rotary apparatus, and described CT bulb and described CT detector are relative to described
Biological sample to be imaged is symmetrical arranged, and wherein, described CT detector electrically connects with described control device.
3. multi-mode imaging system based on structure imaging Yu functional imaging as claimed in claim 1, it is special
Levying and be, described opto-acoustic imaging devices includes that ultrasonic transducer and laser instrument, described ultrasonic transducer are arranged on
On described rotary apparatus, described laser instrument is fixedly installed relative to described biological sample to be imaged, wherein, and institute
State ultrasonic transducer to electrically connect with described controller.
4. multi-mode imaging system based on structure imaging Yu functional imaging as claimed in claim 3, it is special
Levying and be, the line between described biological sample to be imaged and described laser instrument is horizontal axis, described rotation
Device rotates in the perpendicular being perpendicular to described horizontal axis relative to described biological sample to be imaged.
5. multi-mode imaging system based on structure imaging Yu functional imaging as claimed in claim 3, it is special
Levying and be, the line between described biological sample to be imaged and described laser instrument is vertical axis, described rotation
Device rotates in the horizontal plane being perpendicular to described vertical axis relative to described biological sample to be imaged.
6. the multi-mode imaging system based on structure imaging Yu functional imaging as described in claim 4 or 5,
It is characterized in that, described multi-mode imaging system also includes biological sample load bearing seat to be imaged, this life to be imaged
The direction of thing sample load bearing seat line between described biological sample to be imaged and described laser instrument is movably
Arrange, and in carrying out imaging operation, be positioned at described receiving space.
7. multi-mode imaging system based on structure imaging Yu functional imaging as claimed in claim 6, it is special
Levying and be, it is described that described multi-mode imaging system also includes that radiation-resistance mask, described rotary apparatus are arranged on
In radiation-resistance mask, described control device is positioned at outside described radiation-resistance mask.
8. a multi-modality imaging method based on structure imaging Yu functional imaging, it is characterised in that this multimode
It is many based on structure imaging and functional imaging that state formation method uses according to any one of claim 1 to 7
Modality imaging system carries out imaging operation, and described multi-modality imaging method includes following operating procedure:
Step S10: based on structure imaging and functional imaging described in placement biological sample to be imaged is positioned over
In the receiving space that the rotary apparatus of multi-mode imaging system is formed；
Step S20: first open described PET based on structure imaging Yu the multi-mode imaging system of functional imaging
Imaging device gathers the PET scan data of described biological sample to be imaged, is then turned on described based on knot composition
As CT imaging device and opto-acoustic imaging devices with the multi-mode imaging system of functional imaging, and open described
Rotary apparatus based on structure imaging Yu the multi-mode imaging system of functional imaging make described CT imaging device and
Opto-acoustic imaging devices rotates around described biological sample to be imaged, to gather the CT of described biological sample to be imaged
Scan data and optical acoustic scanning data；
Step S30: described control device root based on structure imaging Yu the multi-mode imaging system of functional imaging
It is analyzed according to described PET scan data, described CT scan data and described optical acoustic scanning data and rebuilds
The three-dimensional multimode state image of described biological sample to be imaged.
9. multi-modality imaging method as claimed in claim 8, it is characterised in that in described step S20
In imaging operation, first move described PET imaging device near described biological sample to be imaged to gather institute
State the PET scan data of biological sample to be imaged, mobile described after collection completes described PET scan data
PET imaging device resets, and wherein, described PET imaging device can move along the radial direction of described rotary apparatus
Dynamic.
10. multi-modality imaging method as claimed in claim 8, it is characterised in that in described step S20
Imaging operation in,
Described PET imaging device constitutes closed area around described biological sample to be imaged, treats described in gathering
The PET scan data of the full angle of Imaging biological samples；
Or, described PET imaging device constitutes the enclosed area of predetermined angular around described biological sample to be imaged
Territory, to gather the PET scan data of the limited angular of described biological sample to be imaged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610349251.XA CN105919558A (en) | 2016-05-24 | 2016-05-24 | Multi-modal imaging system and method based on structure imaging and functional imaging |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610349251.XA CN105919558A (en) | 2016-05-24 | 2016-05-24 | Multi-modal imaging system and method based on structure imaging and functional imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105919558A true CN105919558A (en) | 2016-09-07 |
Family
ID=56841102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610349251.XA Pending CN105919558A (en) | 2016-05-24 | 2016-05-24 | Multi-modal imaging system and method based on structure imaging and functional imaging |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105919558A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111068186A (en) * | 2018-10-22 | 2020-04-28 | 清华大学 | CT imaging and image-guided radiotherapy device |
| CN114034670A (en) * | 2021-09-23 | 2022-02-11 | 山东第一医科大学(山东省医学科学院) | Multi-mode fluorescence-terahertz dual-channel imaging system, imaging method and algorithm |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007041452A2 (en) * | 2005-09-30 | 2007-04-12 | New York University | Methods for preparation of live body tissue for examination |
| US20070160271A1 (en) * | 2005-12-29 | 2007-07-12 | R2 Technology, Inc. | Facilitating comparison of medical images |
| CN103389273A (en) * | 2013-08-01 | 2013-11-13 | 中国科学院自动化研究所 | Photo-acoustic and optical integrated multi-mode imaging system |
| CN103815925A (en) * | 2014-03-06 | 2014-05-28 | 北京锐视康科技发展有限公司 | Multi-modal homomorphic isochronic medical image imaging system and method |
-
2016
- 2016-05-24 CN CN201610349251.XA patent/CN105919558A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007041452A2 (en) * | 2005-09-30 | 2007-04-12 | New York University | Methods for preparation of live body tissue for examination |
| US20070160271A1 (en) * | 2005-12-29 | 2007-07-12 | R2 Technology, Inc. | Facilitating comparison of medical images |
| CN103389273A (en) * | 2013-08-01 | 2013-11-13 | 中国科学院自动化研究所 | Photo-acoustic and optical integrated multi-mode imaging system |
| CN103815925A (en) * | 2014-03-06 | 2014-05-28 | 北京锐视康科技发展有限公司 | Multi-modal homomorphic isochronic medical image imaging system and method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111068186A (en) * | 2018-10-22 | 2020-04-28 | 清华大学 | CT imaging and image-guided radiotherapy device |
| CN114034670A (en) * | 2021-09-23 | 2022-02-11 | 山东第一医科大学(山东省医学科学院) | Multi-mode fluorescence-terahertz dual-channel imaging system, imaging method and algorithm |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2634622C2 (en) | Protocol with dose optimisation for attenuation correction and location determination on hybrid scanners | |
| CN105078495B (en) | PET-CT scanning imaging method and related imaging method | |
| US10130320B2 (en) | X-ray CT apparatus and image diagnostic apparatus | |
| Beyer et al. | The future of hybrid imaging—part 3: PET/MR, small-animal imaging and beyond | |
| JP4782680B2 (en) | Calibration image alignment apparatus and method in PET-CT system | |
| AU2017420781A1 (en) | Method for improving cone-beam CT image quality using a deep convolutional neural network | |
| US20120265050A1 (en) | Omni-Tomographic Imaging for Interior Reconstruction using Simultaneous Data Acquisition from Multiple Imaging Modalities | |
| RU2596010C2 (en) | Multi-module compact bore imaging system | |
| CN108883294A (en) | System and method for monitoring structure motion in entire radiotherapy | |
| CN104323789B (en) | A kind of CT scan image rebuilding method and CT scanner | |
| JP2001502047A (en) | How to overlay multi-modality data in a medical imaging system | |
| JP6130840B2 (en) | Adaptive dual path target reconstruction and acquisition | |
| JP2003325499A (en) | Multi modality x-ray and nuclear medicine mammography imaging system and imaging method | |
| US20080009731A1 (en) | Radiotherapy device | |
| CN111566705B (en) | System and method for determining a region of interest in medical imaging | |
| CN205729389U (en) | Multi-modality imaging device and medical image system | |
| CN104220898B (en) | Method for generating PET absorption-corrected image from MR image | |
| CN110264559B (en) | Bone tomographic image reconstruction method and system | |
| JP7463395B2 (en) | DEVICE AND METHOD FOR ANALYZING PHOTOACOUS DATA, PHOTOACOUS SYSTEM AND COMPUTER PROGRAM - Patent application | |
| CN1895185B (en) | Method for displaying information of checking region of checked object and influence of drug in vivo. | |
| CN108042110A (en) | Multi-modality imaging system | |
| CN105919558A (en) | Multi-modal imaging system and method based on structure imaging and functional imaging | |
| Bowsher et al. | Onboard functional and molecular imaging: A design investigation for robotic multipinhole SPECT | |
| CN106248705A (en) | A kind of formation method mixing XRF CT and X-ray acoustic CT and system | |
| JP4385500B2 (en) | Tomographic image processing device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160907 |