CN105902694A - Medicine composition for assisting coronary heart disease postoperative recovery - Google Patents
Medicine composition for assisting coronary heart disease postoperative recovery Download PDFInfo
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- CN105902694A CN105902694A CN201610297948.7A CN201610297948A CN105902694A CN 105902694 A CN105902694 A CN 105902694A CN 201610297948 A CN201610297948 A CN 201610297948A CN 105902694 A CN105902694 A CN 105902694A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/55—Linaceae (Flax family), e.g. Linum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a medicine composition for assisting coronary heart disease postoperative recovery and a preparation method thereof. The medicine composition is prepared from the following medicine in parts by weight: marrubium incisum, diaphragma juglandis, stachyurus pith, puffball, linseeds, crinis carbonisatus, herba polygoni avicularis, Chinese violet, radix serratulae chinensis, trichosanthes palmate, menthol and flos magnolia through the processes of water boiling and alcohol soaking. After the treatment on 360 cases of coronary heart disease postsurgical patients, the total effectiveness rate reaches 94.4 percent; the effect is obvious; the adverse effects and toxic and side effects are not discovered; the result shows that the medicine composition has the obvious curative effect on coronary heart disease postsurgical recovery, and has good popularization values.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to pharmaceutical composition of a kind of aided coronary heart disease post-operative recovery and preparation method thereof.
Background technology
Coronary heart disease is a kind of myocardial ischemia-anoxemia (angina pectoris) caused by coronary heart disease organic (atherosclerosis or dynamic property vasospasm) stenosis or occlusion or the heart disease of myocardial necrosis (myocardial infarction), also known as ischemic heart desease.The coronary heart disease majority that we say at ordinary times is tremulous pulse organic stenosis or obstruction causes, also known as coronary heart disease atherosclerotic heart disease.Its coronary heart disease narrow polyphyly fatty material is piled up caused along blood vessel, and this process is referred to as arteriosclerosis.Arteriosclerosis develops into a certain degree, and coronary heart disease is narrow gradually to be increased the weight of, and limits the blood flow flowing into cardiac muscle.Heart can not get enough oxygen supplies, chest will be occurred uncomfortable, i.e. angina pectoris.The angina pectoris attacks performance of different people differs.Majority describe that it is, and " some patients's sensation is diffused to bilateral shoulder, back, cervical region, bottleneck throat, has a rest or buccal nitroglycerin is alleviated for pressure in chest, " vexed swollen sense " " sense of feeling oppressed ".Myocardial infarction is the another kind of performance of coronary heart disease, and its chest pain symptom is lasting and serious, has a rest or buccal nitroglycerin is invalid.Coronary heart disease total blockage during myocardial infarction, this part cardiac muscle is downright bad because not having blood oxygen.Most due to narrow form blood clot, atheromatous plaque ruptures or the factor such as vasospasm causes.Along with the development of medical science, coronary heart disease is taked implant coronary heart disease support, the netted tubule that coronary heart disease support is made up of particulate metal, after it delivers to the place that coronary heart disease is narrow, it can be by vascular opening so that blood flow keep unimpeded, myocardial ischemia thus alleviate.But support can only relief of symptoms, can not fundamentally suppress atherosclerosis.Therefore, no matter how good effect is to put support, does not all replace the effect of medicine.Patient must adhere to Long-term taking medicine, stops disease progression, prevents coronary heart disease restenosis.Additionally for the patient using drug stent, the about patient of one of percentage left and right there will be thrombosis, thus cause myocardial infarction so we to be preferably minimized the probability of thrombosis within 1 year, need Aspirin and Plavix 1 year (specifically following the doctor's advice).In addition to support itself, need prevent other position of arteria coronaria narrow go out new problem, so must note after stenting preventing for a long time.
Therefore to strengthen postoperative effect, the present inventor have developed a kind of new drug.
Summary of the invention
It is an object of the invention to provide the pharmaceutical composition of a kind of aided coronary heart disease post-operative recovery.
It is a further object of the present invention to provide the preparation method of the pharmaceutical composition of a kind of aided coronary heart disease post-operative recovery.
The pharmaceutical composition of the aided coronary heart disease post-operative recovery that the present invention provides is made up of the medicine of following weight portion: Herba lagopsis supinae 10-50 part, Partition in Fructus Juglandis 10-45 part, Medulla Stachyuri (Medulla Helwingiae) 15-35 part, Lasiosphaera Seu Calvatia 12-36 part, Semen Lini 10-25 part, Crinis Carbonisatus 10-35 part, Herba Polygoni Avicularis 10-45 part, Herba Violae 10-48 part, Radix Serratulae Chinensis 10-40 part, Radix Stephaniae Cepharanthae 10-43 part, Mentholum 10-65 part, Flos Magnoliae 10-35 part.
Preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Herba lagopsis supinae 15-45 part, Partition in Fructus Juglandis 15-40 part, Medulla Stachyuri (Medulla Helwingiae) 18-32 part, Lasiosphaera Seu Calvatia 15-32 part, Semen Lini 12-23 part, Crinis Carbonisatus 12-30 part, Herba Polygoni Avicularis 15-40 part, Herba Violae 15-45 part, Radix Serratulae Chinensis 12-35 part, Radix Stephaniae Cepharanthae 12-40 part, Mentholum 15-60 part, Flos Magnoliae 12-30 part.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Herba lagopsis supinae 20-40 part, Partition in Fructus Juglandis 18-35 part, Medulla Stachyuri (Medulla Helwingiae) 20-30 part, Lasiosphaera Seu Calvatia 18-31 part, Semen Lini 14-22 part, Crinis Carbonisatus 14-28 part, Herba Polygoni Avicularis 18-38 part, Herba Violae 20-40 part, Radix Serratulae Chinensis 15-30 part, Radix Stephaniae Cepharanthae 15-35 part, Mentholum 20-55 part, Flos Magnoliae 15-28 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Herba lagopsis supinae 25-35 part, Partition in Fructus Juglandis 22-30 part, Medulla Stachyuri (Medulla Helwingiae) 22-28 part, Lasiosphaera Seu Calvatia 20-30 part, Semen Lini 15-21 part, Crinis Carbonisatus 15-25 part, Herba Polygoni Avicularis 20-35 part, Herba Violae 25-35 part, Radix Serratulae Chinensis 18-28 part, Radix Stephaniae Cepharanthae 20-30 part, Mentholum 30-42 part, Flos Magnoliae 18-25 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Herba lagopsis supinae 28 parts, Partition in Fructus Juglandis 26 parts, Medulla Stachyuri (Medulla Helwingiae) 26 parts, Lasiosphaera Seu Calvatia 25 parts, Semen Lini 18 parts, Crinis Carbonisatus 20 parts, Herba Polygoni Avicularis 28 parts, Herba Violae 30 parts, Radix Serratulae Chinensis 23 parts, Radix Stephaniae Cepharanthae 25 parts, Mentholum 35 parts, Flos Magnoliae 22 parts.
Pharmaceutical composition of the present invention is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is solid preparation or liquid preparation, and described solid preparation is tablet, capsule, granule or pill；Described liquid preparation is oral liquid.
The method of pharmaceutical composition of the present invention comprises the following steps: Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Crinis Carbonisatus, Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum, Flos Magnoliae pulverize and sieve, mix homogeneously with pharmaceutically acceptable carrier or diluent, be prepared as preparation.
The method of pharmaceutical composition of the present invention comprises the following steps:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 10-15 times amount soak by water 2-4 time, each 0.5-3 hour, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding soak with ethanol 10-20 hour of 6-10 times amount 65-85%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds adjuvant, make pharmaceutically acceptable dosage form.
Preferably, the method for pharmaceutical composition of the present invention comprises the following steps:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 12 times amount soak by water 3 times, each 1.5 hours, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 15 hours of 8 times amount 75%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds adjuvant, make pharmaceutically acceptable dosage form.
Described parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose；
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide, Pulvis Talci or magnesium stearate；
Described surfactant is smooth selected from dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fatty acid Pyrusussuriensis or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The invention have the advantages that
Treatment coronary heart disease postoperative patients 360 example, total effective rate reaches 94.4%, and effect is obvious, and does not finds untoward reaction and toxic and side effects, illustrates that pharmaceutical composition of the present invention is evident in efficacy in aided coronary heart disease post-operative recovery, has good promotional value.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: Herba lagopsis supinae 10g, Partition in Fructus Juglandis 10g, Medulla Stachyuri (Medulla Helwingiae) 15g, Lasiosphaera Seu Calvatia 12g, Semen Lini 10g, Crinis Carbonisatus 10g, Herba Polygoni Avicularis 10g, Herba Violae 10g, Radix Serratulae Chinensis 10g, Radix Stephaniae Cepharanthae 10g, Mentholum 10g, Flos Magnoliae 10g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 10 times amount soak by water 2 times, each 0.5 hour, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 10 hours of 6 times amount 65%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, load capsule, make capsule.
Embodiment 2
Prescription: Herba lagopsis supinae 50g, Partition in Fructus Juglandis 45g, Medulla Stachyuri (Medulla Helwingiae) 35g, Lasiosphaera Seu Calvatia 36g, Semen Lini 25g, Crinis Carbonisatus 35g, Herba Polygoni Avicularis 45g, Herba Violae 48g, Radix Serratulae Chinensis 40g, Radix Stephaniae Cepharanthae 43g, Mentholum 65g, Flos Magnoliae 35g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 15 times amount soak by water 4 times, each 3 hours, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 20 hours of 10 times amount 85%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, load capsule, make capsule.
Embodiment 3
Prescription: Herba lagopsis supinae 15g, Partition in Fructus Juglandis 15g, Medulla Stachyuri (Medulla Helwingiae) 18g, Lasiosphaera Seu Calvatia 15g, Semen Lini 12g, Crinis Carbonisatus 12g, Herba Polygoni Avicularis 15g, Herba Violae 15g, Radix Serratulae Chinensis 12g, Radix Stephaniae Cepharanthae 12g, Mentholum 15g, Flos Magnoliae 12g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 12 times amount soak by water 3 times, each 1 hour, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 12 hours of 8 times amount 70%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 4
Prescription: Herba lagopsis supinae 45g, Partition in Fructus Juglandis 40g, Medulla Stachyuri (Medulla Helwingiae) 32g, Lasiosphaera Seu Calvatia 32g, Semen Lini 23g, Crinis Carbonisatus 30g, Herba Polygoni Avicularis 40g, Herba Violae 45g, Radix Serratulae Chinensis 35g, Radix Stephaniae Cepharanthae 40g, Mentholum 60g, Flos Magnoliae 30g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 14 times amount soak by water 3 times, each 2 hours, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 18 hours of 8 times amount 80%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 5
Prescription: Herba lagopsis supinae 20g, Partition in Fructus Juglandis 18g, Medulla Stachyuri (Medulla Helwingiae) 20g, Lasiosphaera Seu Calvatia 18g, Semen Lini 14g, Crinis Carbonisatus 14g, Herba Polygoni Avicularis 18, Herba Violae 20g, Radix Serratulae Chinensis 15g, Radix Stephaniae Cepharanthae 15g, Mentholum 20g, Flos Magnoliae 15g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 12 times amount soak by water 3 times, each 1.5 hours, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 15 hours of 8 times amount 75%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, load capsule, make capsule.
Embodiment 6
Prescription: Herba lagopsis supinae 40g, Partition in Fructus Juglandis 35g, Medulla Stachyuri (Medulla Helwingiae) 30g, Lasiosphaera Seu Calvatia 31g, Semen Lini 22g, Crinis Carbonisatus 28g, Herba Polygoni Avicularis 38g, Herba Violae 40g, Radix Serratulae Chinensis 30g, Radix Stephaniae Cepharanthae 35g, Mentholum 55g, Flos Magnoliae 28g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 12 times amount soak by water 3 times, each 1.5 hours, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 15 hours of 8 times amount 75%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, load capsule, make capsule.
Embodiment 7
Prescription: Herba lagopsis supinae 25g, Partition in Fructus Juglandis 22g, Medulla Stachyuri (Medulla Helwingiae) 22g, Lasiosphaera Seu Calvatia 20g, Semen Lini 15g, Crinis Carbonisatus 15g, Herba Polygoni Avicularis 20g, Herba Violae 25g, Radix Serratulae Chinensis 18g, Radix Stephaniae Cepharanthae 20g, Mentholum 30g, Flos Magnoliae 18g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 12 times amount soak by water 3 times, each 1.5 hours, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 15 hours of 8 times amount 75%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 8
Prescription: Herba lagopsis supinae 35g, Partition in Fructus Juglandis 30g, Medulla Stachyuri (Medulla Helwingiae) 28g, Lasiosphaera Seu Calvatia 30g, Semen Lini 21g, Crinis Carbonisatus 25g, Herba Polygoni Avicularis 35g, Herba Violae 35g, Radix Serratulae Chinensis 28g, Radix Stephaniae Cepharanthae 30g, Mentholum 42g, Flos Magnoliae 25g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 12 times amount soak by water 3 times, each 1.5 hours, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 15 hours of 8 times amount 75%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 9
Prescription: Herba lagopsis supinae 28g, Partition in Fructus Juglandis 26g, Medulla Stachyuri (Medulla Helwingiae) 26g, Lasiosphaera Seu Calvatia 25g, Semen Lini 18g, Crinis Carbonisatus 20g, Herba Polygoni Avicularis 28g, Herba Violae 30g, Radix Serratulae Chinensis 23g, Radix Stephaniae Cepharanthae 25g, Mentholum 35g, Flos Magnoliae 22g.
Preparation method:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum being added 12 times amount soak by water 3 times, each 1.5 hours, filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae adding the soak with ethanol 15 hours of 8 times amount 75%, filters, filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds the starch accounting for mix homogeneously fine powder weight 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
In order to sketch beneficial effects of the present invention further, inventor provide clinical trial data, specific as follows:
1, case source
Randomly select 360 postoperative patients of coronary heart disease in 6 hospitals to test, be divided into 9 groups, there was no significant difference between each group, age 23～60 years old, clinical symptoms: cardiopalmus, chest pain, uncomfortable in chest, dyspnea.
2, Therapeutic Method
Use above-mentioned prepared embodiment 1-9 pharmaceutical composition, oral, a 3g, one day 3 times, observes curative effect.
3, criterion of therapeutical effect
Efficacy assessment standard: efficacy assessment standard is formulated with reference to " Chinese medicine Clinical Researches of New Drugs guideline ": cure: Clinical symptom and sign disappears；
Effective: Clinical symptom and sign substantially or mostly disappears；
Effective: Clinical symptom and sign has and alleviates or alleviate；
Invalid: Clinical symptom and sign is without improving.
4, experimental result
Most patients is using about 15 days symptoms of medicine alleviating according to the inventive method, after taking 30 days, the results are shown in Table 1:
Table 1 curative effect statistical table
| Group | Clinical recovery | Effective | Effectively | Invalid | Add up to | Effective percentage (%) |
| Embodiment 1 | 18 | 12 | 8 | 2 | 40 | 95.0% |
| Embodiment 2 | 19 | 9 | 9 | 3 | 40 | 92.5% |
| Embodiment 3 | 20 | 8 | 9 | 3 | 40 | 92.5% |
| Embodiment 4 | 21 | 8 | 9 | 2 | 40 | 95.0% |
| Embodiment 5 | 18 | 8 | 11 | 3 | 40 | 92.5% |
| Embodiment 6 | 20 | 8 | 11 | 1 | 40 | 97.5% |
| Embodiment 7 | 17 | 12 | 9 | 2 | 40 | 95.0% |
| Embodiment 8 | 18 | 8 | 12 | 2 | 40 | 95.0% |
| Embodiment 9 | 20 | 9 | 9 | 2 | 40 | 95.0% |
Treatment coronary heart disease postoperative patients 360 example, total effective rate reaches 94.4%, and effect is obvious, and does not finds untoward reaction and toxic and side effects, illustrates that pharmaceutical composition of the present invention is evident in efficacy in aided coronary heart disease post-operative recovery, has good promotional value.
Although, use general explanation, detailed description of the invention and test, the present invention is described in detail, but on the basis of the present invention, it can be made some amendments or improve, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (10)
1. the pharmaceutical composition of an aided coronary heart disease post-operative recovery, it is characterised in that this drug regimen
Thing is made up of the medicine of following weight portion: Herba lagopsis supinae 10-50 part, Partition in Fructus Juglandis 10-45 part, Medulla Stachyuri (Medulla Helwingiae)
15-35 part, Lasiosphaera Seu Calvatia 12-36 part, Semen Lini 10-25 part, Crinis Carbonisatus 10-35 part, Herba Polygoni Avicularis 10-45
Part, Herba Violae 10-48 part, Radix Serratulae Chinensis 10-40 part, Radix Stephaniae Cepharanthae 10-43 part, Mentholum 10-65
Part, Flos Magnoliae 10-35 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that this pharmaceutical composition by
The medicine of following weight portion is made: Herba lagopsis supinae 15-45 part, Partition in Fructus Juglandis 15-40 part, Medulla Stachyuri (Medulla Helwingiae) 18-32
Part, Lasiosphaera Seu Calvatia 15-32 part, Semen Lini 12-23 part, Crinis Carbonisatus 12-30 part, Herba Polygoni Avicularis 15-40 part,
Herba Violae 15-45 part, Radix Serratulae Chinensis 12-35 part, Radix Stephaniae Cepharanthae 12-40 part, Mentholum 15-60 part,
Flos Magnoliae 12-30 part.
Pharmaceutical composition the most according to claim 2, it is characterised in that this pharmaceutical composition by
The medicine of following weight portion is made: Herba lagopsis supinae 20-40 part, Partition in Fructus Juglandis 18-35 part, Medulla Stachyuri (Medulla Helwingiae) 20-30
Part, Lasiosphaera Seu Calvatia 18-31 part, Semen Lini 14-22 part, Crinis Carbonisatus 14-28 part, Herba Polygoni Avicularis 18-38 part,
Herba Violae 20-40 part, Radix Serratulae Chinensis 15-30 part, Radix Stephaniae Cepharanthae 15-35 part, Mentholum 20-55 part,
Flos Magnoliae 15-28 part.
Pharmaceutical composition the most according to claim 3, it is characterised in that this pharmaceutical composition by
The medicine of following weight portion is made: Herba lagopsis supinae 25-35 part, Partition in Fructus Juglandis 22-30 part, Medulla Stachyuri (Medulla Helwingiae) 22-28
Part, Lasiosphaera Seu Calvatia 20-30 part, Semen Lini 15-21 part, Crinis Carbonisatus 15-25 part, Herba Polygoni Avicularis 20-35 part,
Herba Violae 25-35 part, Radix Serratulae Chinensis 18-28 part, Radix Stephaniae Cepharanthae 20-30 part, Mentholum 30-42 part,
Flos Magnoliae 18-25 part.
Pharmaceutical composition the most according to claim 4, it is characterised in that this pharmaceutical composition by
The medicine of following weight portion is made: Herba lagopsis supinae 28 parts, Partition in Fructus Juglandis 26 parts, Medulla Stachyuri (Medulla Helwingiae) 26 parts, Lasiosphaera Seu Calvatia
25 parts, Semen Lini 18 parts, Crinis Carbonisatus 20 parts, Herba Polygoni Avicularis 28 parts, Herba Violae 30 parts, Radix Serratulae Chinensis
23 parts, Radix Stephaniae Cepharanthae 25 parts, Mentholum 35 parts, Flos Magnoliae 22 parts.
6. according to the pharmaceutical composition described in any one of claim 1-5, it is characterised in that this medicine
Compositions is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition the most according to claim 6, it is characterised in that described pharmaceutical composition
For solid preparation or liquid preparation, described solid preparation is tablet, capsule, granule or pill；
Described liquid preparation is oral liquid.
8. the method preparing pharmaceutical composition described in any one of claim 1-5, its feature exists
In, the method comprises the following steps: Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, blood
Remaining charcoal, Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum, Flos Magnoliae pulverize and sieve, with medicine
On, acceptable carrier or diluent mix homogeneously, be prepared as preparation.
9. the method preparing pharmaceutical composition described in any one of claim 1-5, its feature exists
In, the method comprises the following steps:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum are added 10-15 times amount soak by water
2-4 time, each 0.5-3 hour, filtering, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder,
Standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae are added 6-10 times amount 65-85%
Soak with ethanol 10-20 hour, filter, filtrate concentrate, dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds adjuvant, make pharmaceutically acceptable
Dosage form.
The preparation method of pharmaceutical composition the most according to claim 9, it is characterised in that should
Method comprises the following steps:
1) medicine of weight portion is weighed, standby；
2) Crinis carbonisatus powder is broken into fine powder, standby；
3) Herba Polygoni Avicularis, Herba Violae, Radix Serratulae Chinensis, Radix Stephaniae Cepharanthae, Mentholum are added 12 times amount soak by water 3
Secondary, each 1.5 hours, to filter, merging filtrate, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) Herba lagopsis supinae, Partition in Fructus Juglandis, Medulla Stachyuri (Medulla Helwingiae), Lasiosphaera Seu Calvatia, Semen Lini, Flos Magnoliae are added 8 times amount 75%
Soak with ethanol 15 hours, filters, and filtrate concentrates, and dry, pulverize into fine powder standby；
5) by step 2) 3) 4) standby fine powder merges, adds adjuvant, make pharmaceutically acceptable
Dosage form.
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| CN106310193A (en) * | 2016-09-23 | 2017-01-11 | 李同磊 | Medicine composition for assisting postoperative recovery of heart diseases |
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Application publication date: 20160831 |