CN105902653A - Plaster special for upper respiratory tract cough in children induced by respiratory syncytial virus infection - Google Patents
Plaster special for upper respiratory tract cough in children induced by respiratory syncytial virus infection Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract
The invention relates to an ointment for external application, and more specifically relates to a plaster special for upper respiratory tract cough in children induced by respiratory syncytial virus infection. The plaster is prepared by the following raw materials in parts by weight: 60-80 parts of osmanthus fruits, 20-25 parts of Zanthoxylum armatum, 80-90 parts of Origanum majorana, 50-55 parts of masson pine leaves, 10-12 parts of lecithin, 1.8-2.4 parts of choline, and 3-5 parts of carotene, wherein condensed extract liquid of the osmanthus fruits, Zanthoxylum armatum, Origanum majorana and masson pine leaves is used. The plaster special for upper respiratory tract cough in children induced by respiratory syncytial virus infection is directly applied to affected parts, active components have good permeability, and the plaster has good effects for killing respiratory syncytial virus, preventing protein synthesis of respiratory syncytial virus, promoting sticky and purulent secretion discharge, and eliminating inflammation; the plaster has the advantages of low raw material cost, usage convenience, and substantial curative effects; clinic experiments prove that the plaster can be continuously applied for four times in order to play the efficacy for relieving cough generally, and the plaster has usage safety and does not have irritation as well as toxic and side effects for children.
Description
Technical field
The present invention relates to a kind of external application medical ointment, be specifically related to the upper respiratory tract special emplastrum of cough that a kind of children respiratory syncytial virus infection causes.
Background technology
Cough is a kind of protectiveness respiration reflex action of human body, and Respiratory Syncytial Virus(RSV) is a kind of RNA virus, belongs to Paramyxoviridae.This disease is propagated through the air spittle and close contact.It is more common in neonate and the baby within 6 months.3 ~ 7 days incubation periods.Infant's symptom is heavier, can have high heat, rhinitis, pharyngitis and laryngitis, show as capillary bronchitis and pneumonia later.Minority sick child can concurrently tympanitis, pleurisy and myocarditis etc..After adult and older children infect, mainly show as the infection of the upper respiratory tract, mostly the arch-criminal of children's upper respiratory tract cough is virus, antibiotics is primarily directed to bacterium and infects, invalid to virus, not only during cough, abuse of antibiotics does not improves symptom, and bacterium can be promoted on the contrary to produce drug resistance, when real generation is infected, medicine is possible to lose curative effect.
Summary of the invention
It is an object of the invention to provide that a kind of cost is relatively low, easy to use, curative effect children's cold emplastrum faster.
The technical solution used in the present invention is, the upper respiratory tract special emplastrum of cough that a kind of children respiratory syncytial virus infection causes, and this emplastrum is made up of the raw material of following parts by weight,
Cassia bud 60-80 part, rattan green pepper 20-25 part, ink angle orchid 80-90 part, Pinus massoniana 50-55 part, soft phosphatidase 1 0-12 part, choline 1.8-2.4 part, carrotene 3-5 part.
During making,
Cassia bud is broken to 80 mesh, add the ethanol microwave abstracting of its weight 8-10 times, extraction power is 460-465W for the first time, extraction time is 95s, and second time extraction power is 390-400W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60-70s, taking extract, filter, it is the medicinal extract of 1.08-1.11 that filtrate is concentrated into the relative density when 65 DEG C；
Rattan green pepper is crushed to 80 mesh, add the ethanol microwave abstracting of its weight 8-10 times, extraction power is 470-480W for the first time, extraction time is 120s, and second time extraction power is 400-410W, and extraction time is 80s, extraction for the first time and second time extraction time interval 80-85s, taking extract, filter, it is the medicinal extract of 1.21-1.23 that filtrate is concentrated into the relative density when 65 DEG C；
Ink angle orchid is broken to 80 mesh, add the water microwave abstracting of its weight 6-8 times, extraction power is 340-360W for the first time, extraction time is 100s, and second time extraction power is 280-300W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60-70s, taking extract, filter, it is the medicinal extract of 1.17-1.18 that filtrate is concentrated into the relative density when 65 DEG C；
Pinus massoniana is broken to 80 mesh, add the water microwave abstracting of its weight 6-8 times, extraction power is 380-400W for the first time, extraction time is 60s, and second time extraction power is 320-340W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60-70s, taking extract, filter, it is the medicinal extract of 1.24-1.25 that filtrate is concentrated into the relative density when 65 DEG C；
By soft phosphatide and cassia bud medicinal extract, rattan green pepper medicinal extract, ink angle orchid medicinal extract, Pinus massoniana medicinal extract, choline, carrotene mixing and stirring, obtain the upper respiratory tract special emplastrum of cough that children respiratory syncytial virus infection causes.
Children's cold emplastrum with emplastrum in use, is coated at infant neck by this children's cold, wipes with hot towel after 20-30 minute.
The upper respiratory tract special emplastrum of cough that children's upper respiratory tract syncytial virus infection of the present invention causes directly acts on affected part, and active ingredient permeability is strong, has Respiratory Syncytial Virus(RSV) and kills more by force effect, and Respiratory Syncytial Virus(RSV) albumen can be stoped to synthesize, promote that glutinous purulent secretion is discharged, diminish inflammation, this emplastrum low raw-material cost, easy to use, evident in efficacy, through clinical trial certificate, stick four times the most continuously and just can play cough-relieving effect, use safety, the non-stimulated and toxic and side effect to children.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be described:
Embodiment 1, the upper respiratory tract that a kind of children respiratory syncytial virus infection causes coughs special emplastrum, and this emplastrum is made up of the raw material of following parts by weight,
Cassia bud 60 parts, rattan green pepper 20 parts, blue 80 parts of ink angle, Pinus massoniana 50 parts, soft phosphatidase 10 part, 1.8 parts of choline, carrotene 3 parts.
During making,
Cassia bud is broken to 80 mesh, add the ethanol microwave abstracting of its weight 8 times, extraction power is 460W for the first time, extraction time is 95s, and second time extraction power is 390W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60s, taking extract, filter, it is the medicinal extract of 1.08 that filtrate is concentrated into the relative density when 65 DEG C；
Rattan green pepper is crushed to 80 mesh, add the ethanol microwave abstracting of its weight 8 times, extraction power is 470W for the first time, extraction time is 120s, and second time extraction power is 400W, and extraction time is 80s, extraction for the first time and second time extraction time interval 80s, taking extract, filter, it is the medicinal extract of 1.21 that filtrate is concentrated into the relative density when 65 DEG C；
Ink angle orchid is broken to 80 mesh, add the water microwave abstracting of its weight 6 times, extraction power is 340W for the first time, extraction time is 100s, and second time extraction power is 280W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60s, taking extract, filter, it is the medicinal extract of 1.17 that filtrate is concentrated into the relative density when 65 DEG C；
Pinus massoniana is broken to 80 mesh, add the water microwave abstracting of its weight 6 times, extraction power is 380W for the first time, extraction time is 60s, and second time extraction power is 320W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60s, taking extract, filter, it is the medicinal extract of 1.24 that filtrate is concentrated into the relative density when 65 DEG C；
By soft phosphatide and cassia bud medicinal extract, rattan green pepper medicinal extract, ink angle orchid medicinal extract, Pinus massoniana medicinal extract, choline, carrotene mixing and stirring, obtain the upper respiratory tract special emplastrum of cough that children respiratory syncytial virus infection causes.
The upper respiratory tract that embodiment 2, a kind of children respiratory syncytial virus infection cause is coughed special emplastrum, and this emplastrum is made up of the raw material of following parts by weight,
Cassia bud 80 parts, rattan green pepper 25 parts, blue 90 parts of ink angle, Pinus massoniana 55 parts, soft phosphatidase 12 parts, 2.4 parts of choline, carrotene 5 parts.
During making,
Cassia bud is broken to 80 mesh, add the ethanol microwave abstracting of its weight 10 times, extraction power is 465W for the first time, extraction time is 95s, and second time extraction power is 400W, and extraction time is 60s, extraction for the first time and second time extraction time interval 70s, taking extract, filter, it is the medicinal extract of 1.11 that filtrate is concentrated into the relative density when 65 DEG C；
Rattan green pepper is crushed to 80 mesh, add the ethanol microwave abstracting of its weight 10 times, extraction power is 480W for the first time, extraction time is 120s, and second time extraction power is 410W, and extraction time is 80s, extraction for the first time and second time extraction time interval 80s, taking extract, filter, it is the medicinal extract of 1.21 that filtrate is concentrated into the relative density when 65 DEG C；
Ink angle orchid is broken to 80 mesh, add the water microwave abstracting of its weight 8 times, extraction power is 360W for the first time, extraction time is 100s, and second time extraction power is 300W, and extraction time is 60s, extraction for the first time and second time extraction time interval 70s, taking extract, filter, it is the medicinal extract of 1.18 that filtrate is concentrated into the relative density when 65 DEG C；
Pinus massoniana is broken to 80 mesh, add the water microwave abstracting of its weight 8 times, extraction power is 400W for the first time, extraction time is 60s, and second time extraction power is 340W, and extraction time is 60s, extraction for the first time and second time extraction time interval 70s, taking extract, filter, it is the medicinal extract of 1.25 that filtrate is concentrated into the relative density when 65 DEG C；
By soft phosphatide and cassia bud medicinal extract, rattan green pepper medicinal extract, ink angle orchid medicinal extract, Pinus massoniana medicinal extract, choline, carrotene mixing and stirring, obtain the upper respiratory tract special emplastrum of cough that children respiratory syncytial virus infection causes.
The upper respiratory tract that embodiment 3, a kind of children respiratory syncytial virus infection cause is coughed special emplastrum, and this emplastrum is made up of the raw material of following parts by weight,
Cassia bud 70 parts, rattan green pepper 22 parts, blue 85 parts of ink angle, Pinus massoniana 53 parts, soft phosphatidase 11 part, 2 parts of choline, carrotene 4 parts.
During making,
Cassia bud is broken to 80 mesh, add the ethanol microwave abstracting of its weight 9 times, extraction power is 462W for the first time, extraction time is 95s, and second time extraction power is 395W, and extraction time is 60s, extraction for the first time and second time extraction time interval 65s, taking extract, filter, it is the medicinal extract of 1.1 that filtrate is concentrated into the relative density when 65 DEG C；
Rattan green pepper is crushed to 80 mesh, add the ethanol microwave abstracting of its weight 9 times, extraction power is 475W for the first time, extraction time is 120s, and second time extraction power is 405W, and extraction time is 80s, extraction for the first time and second time extraction time interval 82s, taking extract, filter, it is the medicinal extract of 1.22 that filtrate is concentrated into the relative density when 65 DEG C；
Ink angle orchid is broken to 80 mesh, add the water microwave abstracting of its weight 7 times, extraction power is 350W for the first time, extraction time is 100s, and second time extraction power is 290W, and extraction time is 60s, extraction for the first time and second time extraction time interval 65s, taking extract, filter, it is the medicinal extract of 1.175 that filtrate is concentrated into the relative density when 65 DEG C；
Pinus massoniana is broken to 80 mesh, add the water microwave abstracting of its weight 6-8 times, extraction power is 390W for the first time, extraction time is 60s, and second time extraction power is 330W, and extraction time is 60s, extraction for the first time and second time extraction time interval 65s, taking extract, filter, it is the medicinal extract of 1.245 that filtrate is concentrated into the relative density when 65 DEG C；
By soft phosphatide and cassia bud medicinal extract, rattan green pepper medicinal extract, ink angle orchid medicinal extract, Pinus massoniana medicinal extract, choline, carrotene mixing and stirring, obtain the upper respiratory tract special emplastrum of cough that children respiratory syncytial virus infection causes.
Choose health, the big white mouse 80 of close 15 ages in days of body weight, respectively with 0.1ml/ RSV suspension collunarium inoculation big white mouse, one time 1 day, for three days on end, after 3 days, big white mouse is randomly divided into A, B, C, D tetra-groups, often group 20, A group clear water is applied at rat neck；The upper respiratory tract special emplastrum of cough that B group children respiratory of the present invention syncytial virus infection causes is applied at rat neck；C group herbs ' water-decoctum is applied at rat neck, the raw material of the following parts by weight of this herbs ' water-decoctum is made, cassia bud 60-80 part, rattan green pepper 20-25 part, ink angle orchid 80-90 part, Pinus massoniana 50-55 part, this herbs ' water-decoctum is when making, by cassia bud, rattan green pepper, ink angle is blue, Pinus massoniana adds 60-80 times of soak by water 30 minutes, D group Chinese medical concrete is applied at rat neck, the raw material of the following parts by weight of this Chinese medical concrete is made, cassia bud 60-80 part, rattan green pepper 20-25 part, ink angle orchid 80-90 part, Pinus massoniana 50-55 part, this Chinese medical concrete preparation method is identical with control group B.
After tetra-groups of rat process of A, B, C, D terminate, with 3% yellow Jackets 0.5ml intraperitoneal injection of anesthesia, back of the body position is fixed rat, is cut off skin of neck, blunt separation escape pipe, cutting a little orotracheal tube with scissors, sutures is fastened fixing, and the conduit other end is connected with respiratory-flow transducer, reason of delivering a child signal acquiring processing system, being connected with computer, by computer disposal, detection obtains tri-groups of rat mean airway resistances of A, C, D and is respectively 0.582cmH2O/(ml·s)、0.553 cmH2O/(ml·s) 、0.422 cmH2O/ (ml s), B group rat mean airway resistance is respectively 0.301cmH2O/(ml·s)。
All being put to death by three groups of rats, the aseptic lung tissue of rats that takes, and be soaked in 10% formalin solution fixing, conventional dehydration, specimens paraffin embedding slices, HE dyes, and observes lung tissue of rats pathological change situation；
As a result, big amount lymphocyte, thick liquid cell, Eosinophil Infiltration seen from two groups of interstitial lungs of A, C, in alveolar wall, thickness thickens 2-3 level；
D group interstitial lung has a small amount of lymphocyte, thick liquid cell, Eosinophil Infiltration, and in alveolar wall, thickness thickens 1 grade；
B group alveolar wall is without thickening, and without obvious inflammatory cell infiltration, without congested, completely, tunica mucosa bronchiorum epithelium is complete for bronchus, lung tissue structure.
Claims (2)
1. the upper respiratory tract special emplastrum of cough that a children respiratory syncytial virus infection causes, it is characterised in that this emplastrum is made up of the raw material of following parts by weight,
Cassia bud 60-80 part, rattan green pepper 20-25 part, ink angle orchid 80-90 part, Pinus massoniana 50-55 part, soft phosphatidase 1 0-12 part, choline 1.8-2.4 part, carrotene 3-5 part.
The upper respiratory tract special emplastrum of cough that a kind of children respiratory syncytial virus infection the most according to claim 1 causes, it is characterised in that this children's cold emplastrum making step is as follows:
Cassia bud is broken to 80 mesh, add the ethanol microwave abstracting of its weight 8-10 times, extraction power is 460-465W for the first time, extraction time is 95s, and second time extraction power is 390-400W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60-70s, taking extract, filter, it is the medicinal extract of 1.08-1.11 that filtrate is concentrated into the relative density when 65 DEG C；
Rattan green pepper is crushed to 80 mesh, add the ethanol microwave abstracting of its weight 8-10 times, extraction power is 470-480W for the first time, extraction time is 120s, and second time extraction power is 400-410W, and extraction time is 80s, extraction for the first time and second time extraction time interval 80-85s, taking extract, filter, it is the medicinal extract of 1.21-1.23 that filtrate is concentrated into the relative density when 65 DEG C；
Ink angle orchid is broken to 80 mesh, add the water microwave abstracting of its weight 6-8 times, extraction power is 340-360W for the first time, extraction time is 100s, and second time extraction power is 280-300W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60-70s, taking extract, filter, it is the medicinal extract of 1.17-1.18 that filtrate is concentrated into the relative density when 65 DEG C；
Pinus massoniana is broken to 80 mesh, add the water microwave abstracting of its weight 6-8 times, extraction power is 380-400W for the first time, extraction time is 60s, and second time extraction power is 320-340W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60-70s, taking extract, filter, it is the medicinal extract of 1.24-1.25 that filtrate is concentrated into the relative density when 65 DEG C；
By soft phosphatide and cassia bud medicinal extract, rattan green pepper medicinal extract, ink angle orchid medicinal extract, Pinus massoniana medicinal extract, choline, carrotene mixing and stirring, obtain the upper respiratory tract special emplastrum of cough that children respiratory syncytial virus infection causes.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096698A (en) * | 1994-02-05 | 1994-12-28 | 谢时亮 | The compound method that is used for the anti-nasal drops that cures cold |
| CN102302685A (en) * | 2011-05-13 | 2012-01-04 | 暨南大学 | Common lophatherum herb extract and preparation method and application thereof |
| CN104435294A (en) * | 2014-10-16 | 2015-03-25 | 北京东方运嘉科技发展有限公司 | Traditional Chinese medicine for treating respiratory viral infection and pharmaceutical application thereof |
| CN104758362A (en) * | 2015-04-26 | 2015-07-08 | 淄博齐鼎立专利信息咨询有限公司 | Application of Chinese traditional medicine composition in preparing medicine for resisting respiratory syncytial viruses |
-
2016
- 2016-06-03 CN CN201610385966.0A patent/CN105902653A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096698A (en) * | 1994-02-05 | 1994-12-28 | 谢时亮 | The compound method that is used for the anti-nasal drops that cures cold |
| CN102302685A (en) * | 2011-05-13 | 2012-01-04 | 暨南大学 | Common lophatherum herb extract and preparation method and application thereof |
| CN104435294A (en) * | 2014-10-16 | 2015-03-25 | 北京东方运嘉科技发展有限公司 | Traditional Chinese medicine for treating respiratory viral infection and pharmaceutical application thereof |
| CN104758362A (en) * | 2015-04-26 | 2015-07-08 | 淄博齐鼎立专利信息咨询有限公司 | Application of Chinese traditional medicine composition in preparing medicine for resisting respiratory syncytial viruses |
Non-Patent Citations (1)
| Title |
|---|
| 王运芳等: "活血化淤与清热解毒药同用治疗小儿病毒肺炎80例疗效观察(附动物实验结果)", 《医学通讯》 * |
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Application publication date: 20160831 |