CN1058885C

CN1058885C - Drug-stopping addiction-removing capsule

Info

Publication number: CN1058885C
Application number: CN96122934A
Authority: CN
Inventors: 张玉祖; 张之道; 潘常忠
Original assignee: Kunming Compulsory Detoxification Institute
Current assignee: Kunming Compulsory Detoxification Institute
Priority date: 1996-10-09
Filing date: 1996-10-09
Publication date: 2000-11-29
Anticipated expiration: 2016-10-09
Also published as: CN1179949A

Abstract

The present invention relates to a drug-stopping addiction-removing capsule. According to the principle of determining the treatment based on the differentiation of symptoms and signs of the Chinese medicine, aiming at the harmful effect of the existing drug-stopping medicines on organisms of addicts and through wide sieving, ten-odd Chinese herbal medicines of clematis root, lysimachia capillipes, giant knotweed, dutchmanspipe vine, etc. are adopted and processed according to a certain proportion to obtain the capsule. Pharmacodynamics experiments about abstinence reaction symptoms, skipping phenomenon, dependence and acute toxicity are carried out, and clinical application to more than 7600 people shows that the drug-stopping rate reaches 100%; the capsule has the advantages of rapid control of abstinence syndromes, little abstinence pain, no dependence production, rapid rehabilitation, unique therapeutic effect, convenient carrying and administration, and low cost; the capsule is a relatively ideal drug-stopping medicine at present.

Description

Drug-stopping addiction-removing capsule

The present invention relates to a kind ofly utilize Chinese medicine among the people, carry out the Chinese medicine preparation of detoxification and addiction-removing for the patient who sucks opiates and other psychotropic substances.

The medicine that at present is used to quit drug abuse both at home and abroad mainly is a chemicals, in addition, also has some Chinese medicine preparation, and concrete grammar mainly contains substitution method, poison amount diminishing method, Yadong dormancy method, deprives jus voluntarium; Or reach the purpose of drug rehabilitation with certain some of body of damage people.The used medicine of these methods mainly is the withdrawal symptom (symptomatic treatment) that alleviates the patient.But, also do not reach and alleviate or get rid of dependency addiction drugs to addict's body disease.CN1120949A discloses a kind of " addiction-eliminating and body resistance-strengthening capsule ", CN116946A discloses a kind of " medicine for abstaining from drugs and compound method thereof ", and disclosed drug-breaking medicine is to be processed into by kinds of traditional Chinese medicines substantially, though certain effect is arranged, effect is not ideal.

The objective of the invention is to overcome the deficiency that existing anti-additive medicament exists, provide a kind of national folk Chinese herbal medicine that utilizes to optimize compatibility, refine the capsule make through processing, be used for the addict is alleviated or gets rid of dependency addiction to drugs, make it to get well fast.

Above-mentioned purpose is achieved in that the weight portion with Radix Psammosilenes is the drug-stopping addiction-removing capsule of radix, consists of: 0.25～1 part of 7 2～5 parts of Flos Daturae of 1 portion of Semen Pisi sativi of 2～5 parts of Radix Psammosileness of 2～5 parts of Flos Inulaes of 2～4 portions of Rhizoma Polygonati Odorati of 2～4 parts of Radix Aconiti Kusnezoffii Preparatas of 1～4 part of Radix Aconiti Preparata of 2～4 parts of Radix Flos Jasmini Sambacs of 7.5～12 parts of Rhizoma Typhonii (processed) of 75～12 portions of Caulis Sargentodoxae of 10～14 portions of Caulis Fibraureaes of 10～14 parts of Radix Crepidis Ligneaes of 2～6 parts of MANSHANXIANG of 75～12 parts of Rhizoma Pinelliae Preparatum of 7.5～12 portions of Fructus Xanthii of 10～14 parts of Herba Asaris of 10～14 parts of Herba Aristolochiaes of 12～16 parts of Rhizoma Polygoni Cuspidati of Radix Clematidis.

The processing technique of drug-stopping addiction-removing capsule is as follows: get the fine powder that Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Rhizoma Typhonii (processed), Radix Flos Jasmini Sambac, Semen Pisi sativi seven, Flos Daturae were ground into 100 mesh sieves, by weight mixing 1.; 2 get 13 flavor Chinese herbal medicine such as remaining Radix Clematidis, MANSHANXIANG, Rhizoma Polygoni Cuspidati, Radix Crepidis Ligneae selects separately to eluriate and dries, and is ground into the coarse granule of 10 mesh sieves, feeds intake by recipe quantity, after the abundant moistening standing over night of 75% ethanol, the percolator of evenly packing into 75% ethanol percolation in accordance with the law, is collected percolate, after percolate reclaims ethanol, be concentrated into proportion and be 1.3～1.35 standby, medicinal residues decoct with water secondary, each 2 hours, merging filtrate is concentrated into 1.3～1.35, with twice thick paste merge, mixing is standby; With the fine powder and the thick paste mix homogeneously of mixing, dry below 100 ℃, be ground into the fine powder of 100 mesh sieves, granulate, sterilization, be distributed into capsule, bubble-cap, outsourcing and get final product.

Drug-stopping addiction-removing capsule, because adopting the national folk Chinese herbal medicine makes, raw material sources are wide, cost is low, carried out 7600 person-times clinical experiment through units such as Kunming Compulsory Detoxification Institute, eastern station narcotic house of interwined dragon branch office of Kunming Public Security Bureau, Baoan district of Shenzhen city narcotic house, Lufeng, Guangdong Province county narcotic houses, after taking this medicine, all can withdrawal in 5 days, the withdrawal rate reaches 100%, can control withdrawal symptom rapidly, gives up painful little, do not produce dependence, appetite is promoted, and makes weight increase very fast, the rapid and special effect of rehabilitation.

Below in conjunction with accompanying drawing and take curative effect embodiments of the invention are described in further detail

Fig. 1 is the process chart of drug-stopping addiction-removing capsule

Embodiment 1:

Weight portion with Radix Psammosilenes is the drug-stopping addiction-removing capsule of radix, consists of: 1 part of 75 parts of Flos Daturae of 1 portion of Semen Pisi sativi of 5 parts of Radix Psammosileness of 5 parts of Flos Inulaes of 4 portions of Rhizoma Polygonati Odorati of 2.5 parts of Radix Aconiti Kusnezoffii Preparatas of 2.5 parts of Radix Aconiti Preparatas of 3 parts of Radix Flos Jasmini Sambacs of 10 parts of Rhizoma Typhonii (processed) of 10 portions of Caulis Sargentodoxae of 12 portions of Caulis Fibraureaes of 12 parts of Radix Crepidis Ligneaes of 2 parts of MANSHANXIANG of 7.5 parts of Rhizoma Pinelliae Preparatum of 7.5 portions of Fructus Xanthii of 10 parts of Herba Asaris of 10 parts of Herba Aristolochiaes of 12 parts of Rhizoma Polygoni Cuspidati of Radix Clematidis.

The processing technique of drug-stopping addiction-removing capsule is as follows: get the fine powder that Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Rhizoma Typhonii (processed), Radix Flos Jasmini Sambac, Semen Pisi sativi seven, Flos Daturae were ground into 100 mesh sieves, by weight mixing 1.; 2. get 13 flavor Chinese herbal medicine such as remaining Radix Clematidis, MANSHANXIANG, Rhizoma Polygoni Cuspidati, Radix Crepidis Ligneae and select separately to eluriate and dry, be ground into the coarse granule of 10 mesh sieves, feed intake by recipe quantity, after the abundant moistening standing over night of 75% ethanol, the percolator of evenly packing into 75% ethanol percolation in accordance with the law, is collected percolate, after percolate reclaims ethanol, be concentrated into proportion and be 1.3～1.35 standby, medicinal residues decoct with water secondary, each 2 hours, merging filtrate is concentrated into 1.3～1.35, with twice thick paste merge, mixing is standby; With the fine powder and the thick paste mix homogeneously of mixing, dry below 100 ℃, be ground into the fine powder of 100 mesh sieves, granulate, sterilization, be distributed into capsule, bubble-cap, outsourcing and get final product.

The king * *, man, 27 years old.Unmarried.High chinesization, people from Kunming, individuality will be instigateed suction heroin since the end of the year 88, one month habit-forming, every day 3～5 times, every day about 0.6 gram, dosage gradually later on.Change intravenous injection in January, 92 into, inject 4～6 every day after in April, 93, and average 1.5 grams were gone into narcotic house and once injected about 0.5 gram of 1 pin in preceding 3 hours every day.Be typical drug abuse looks when having a physical examination, the laboratory checks that the urine morphine is qualitative positive, takes this medicine after going into institute, withdrawal symptom alleviates gradually to disappearance after the 3rd day, and diet, sleep recover normal, residence 32 days after the 5th day, 16 kilograms of weight increase, each side is all better after two months.

Embodiment 2:

Weight portion with Radix Psammosilenes is the drug-stopping addiction-removing capsule of radix, consists of: 0.6 part of 7 3.5 parts of Flos Daturae of 1 portion of Semen Pisi sativi of 3.5 parts of Radix Psammosileness of 3.5 parts of Flos Inulaes of 3 portions of Rhizoma Polygonati Odorati of 2 parts of Radix Aconiti Kusnezoffii Preparatas of 1 part of Radix Aconiti Preparata of 2 parts of Radix Flos Jasmini Sambacs of 7.5 parts of Rhizoma Typhonii (processed) of 7.5 portions of Caulis Sargentodoxae of 10 portions of Caulis Fibraureaes of 10 parts of Radix Crepidis Ligneaes of 6 parts of MANSHANXIANG of 12 parts of Rhizoma Pinelliae Preparatum of 12 portions of Fructus Xanthii of 14 parts of Herba Asaris of 14 parts of Herba Aristolochiaes of 16 parts of Rhizoma Polygoni Cuspidati of Radix Clematidis.

Its processing technique is constant, the Therefore, omited.

The Meng * *, the woman is 24 years old, married, because of inhale, injection heroin 3 years is surplus, goes into narcotic house's drug rehabilitation on April 4th, 94, this patient instigates suction heroin since in April, 89, changes intravenous injection into so far in 92 years, every day three times after in August, 93, each 0.3 gram is gone into the first two hour and was once injected once.Check when going into institute that extremity all have the entry needle scar, laboratory assay, routine blood test is normal, checks that the urine morphine is qualitative positive, is diagnosed as heroin and relies on, give this medicine after 5 days, the physical withdrawal transference cure, clinical withdrawal, health enters convalescence, residence 28 daily weights increase by 6 kilograms, and rehabilitation goes out institute after two months.

Embodiment 3:

Weight portion with Radix Psammosilenes is the drug-stopping addiction-removing capsule of radix, consists of: 1 part of 75 parts of Flos Daturae of 1 portion of Semen Pisi sativi of 5 parts of Radix Psammosileness of 5 parts of Flos Inulaes of 4 portions of Rhizoma Polygonati Odorati of 2 parts of Radix Aconiti Kusnezoffii Preparatas of 1 part of Radix Aconiti Preparata of 2 parts of Radix Flos Jasmini Sambacs of 7.5 parts of Rhizoma Typhonii (processed) of 7.5 portions of Caulis Sargentodoxae of 10 portions of Caulis Fibraureaes of 10 parts of Radix Crepidis Ligneaes of 4 parts of MANSHANXIANG of 9 parts of Rhizoma Pinelliae Preparatum of 9 portions of Fructus Xanthii of 12 parts of Herba Asaris of 12 parts of Herba Aristolochiaes of 14 parts of Rhizoma Polygoni Cuspidati of Radix Clematidis.

Its processing technique is constant, and the medicine of producing with this prescription carries out clinical verification, and its effect is all good, and its model case is as follows:

The king * *, woman, 26 years old, first chinesization, self-employed entrepreneurs, this patient sucks heroin since in August, 90, every day 1, gram was inhaled 6～8 every day, and is habit-forming after one month, change intravenous injection into after 1 year, the serious sleep disorder of drug abuse future trouble, orthobiosis, pattern was broken, DB.Check when going into narcotic house: sanity, the drug abuse face, abdomen is soft, the visible new and old injection pinprick of extremity and bilateral groin, local nothing infects, and the laboratory checks that the urine morphine is qualitative positive.Be diagnosed as the heroin dependence according to medical history and sign result of laboratory test.Go into institute back and give this medicine treatment, symptom after taking medicine obviously alleviates, and second day obvious symptom has xerostomia, dysphoria, myasthenia of limbs, night difficulty falling asleep, the time gape is arranged, shiver with cold.Third and fourth day, main symptom was weak, and sleep takes a turn for the better, and idol has thirsty, five, six days main symptoms have: sleep, diet recover normally substantially, the physical withdrawal transference cure, and subjective symptoms is clearly better, do not have special discomfort, health enters convalescence, goes out institute behind the one and a half months.

Claims

1. drug-stopping addiction-removing capsule is characterized in that it is made by following method:

A, get 2～4 parts of Radix Aconiti Preparatas, 2～4 parts of Radix Aconiti Kusnezoffii Preparatas, 2～4 parts of Rhizoma Typhonii (processed), 1～4 part of Radix Flos Jasmini Sambac, 7 2～5 parts of Semen Pisi sativis, 0.25～1 part of Flos Daturae, be ground into the fine powder mixing of 100 mesh sieves;

B, get 12～16 parts of Radix Clematidis, 10～14 parts of Rhizoma Polygoni Cuspidati, 10～14 parts of Herba Aristolochiaes, 7.5～12 parts of Herba Asaris, 7.5～12 parts of Fructus Xanthii, 2～6 parts of Rhizoma Pinelliae Preparatum, 10～14 parts of MANSHANXIANG, 10～14 parts of Radix Crepidis Ligneaes, 7.5～12 parts of Caulis Fibraureaes, 7.5～12 parts of Caulis Sargentodoxae, 2～5 parts of Rhizoma Polygonati Odorati, 2～5 parts of Flos Inulaes, 1 part of Radix Psammosilenes, 13 flavor Chinese medicines are selected elutriation separately to be dried, be ground into the coarse granule of 10 mesh sieves, feed intake by recipe quantity, with the abundant moistening standing over night of 75% ethanol, the percolator of evenly packing into, with 75% ethanol percolation in accordance with the law, collect percolate, after percolate reclaims ethanol, be concentrated into proportion and be 1.3～1.35 standby, medicinal residues decoct with water secondary, each 2 hours, merging filtrate was concentrated into 1.3～1.35, and twice thick paste merged, mixing is standby;

C, with the fine powder and the thick paste mix homogeneously of mixing, dry below 100 ℃, be ground into the fine powder of 100 mesh sieves, granulate, sterilization, be distributed into capsule, bubble-cap, outsourcing.