CN105854089A - Method for preparing absorbable biomedical film - Google Patents
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- CN105854089A CN105854089A CN201610202119.6A CN201610202119A CN105854089A CN 105854089 A CN105854089 A CN 105854089A CN 201610202119 A CN201610202119 A CN 201610202119A CN 105854089 A CN105854089 A CN 105854089A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/045—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Materials For Medical Uses (AREA)
Abstract
The present invention provides a method for preparing an absorbable biomedical film. The method is as below: first adding polycaprolactone, polytetrafluoroethylene, vegetable starch, chitosan, paraffin, glycerol and barium stearate to a mixer, mixing and stirring, and then transferring the obtained material to a reaction vessel, adding acrylamide, poly hydroxyethyl methacrylate, poly(butylene succinate), soy lecithin, citric acid and polyethylene wax, heating and stirring, cooling to room temperature, then adding an antioxidant into the obtained material, granulating in a twin-screw extruder, finally blowing the obtained pellets into film by ablowing machine. The absorbable biomedical film has tensile strength of 18MPa, elongation at break of 12% and vitrification temperature of 10 DEG C, not only has good mechanical properties, but also has excellent initial resistance to degradation.
Description
Technical field
The invention belongs to biological medicine field of material technology, be specifically related to the preparation method of a kind of absorbable biological medicinal membrane.
Background technology
Adhesion is the common complication that a danger is high.Adhesion can be understood as internal cicatrization, due to tissue damaged
After need to carry out reparation and reinvent.Under inflammation chemotaxis, transforming factor and cytokine promote to stimulate fibroblasts to secrete big
Caused by amount collagen, local deposits, its mechanism has a lot of problem the clearest and the most definite.It is reported: in abdominal first, have height
The patient reaching 93% finds adhesion in various degree when second-look laparoscopy.The post-operative complication that adhesion can cause, including little
Intestinal obstruction, secondary infertility and abdomen pelvic pain.The therapeutic choice that adhesion is also possible to as patient is following brings puzzlement.Hands
The sequela that postoperative tissue adhesion brings is: operative site constant pain, postoperative epilepsy, loses partial function, and adds
The difficulty again performed the operation and the potentiality that complication occurs.
Operation antiblocking film is also called absorbable medical film, and the macromolecule being made up of degradable medical materials such as polylactic acid is medical
Functional material forms, and can be degraded to CO within the intended time2And H2The little molecule such as O is absorbed by the body or excretes.
In surgical operation, utilize " temporary barrier " of film to act on, be isolated in wound surface between surrounding tissue, glue with prevention of postoperative
Generation even.Biological antiadhesion barrier is applicable to a lot of diseases, including common surgical operation, obstetrics and gynecology operation, bone surgery.
At present clinical practice has a variety of for preparing the material of operation antiblocking, as hyaluronate sodium, polylactic acid, chitosan,
Oxidized regenerated cellulose and hydroxymethyl cellulose etc., but above-mentioned material limited pliability, be unfavorable for actual application.Studies in China
More is, and absorbable polylactic acid-based solid material reaches isolate wound surface and reduce the purpose of adhesion, but owing to it is higher strong
Degree and rigidity, poor pliability and impact resistance, its Clinical practice effect is the most unsatisfactory.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art to provide the preparation method of a kind of absorbable biological medicinal membrane, this can
Organism-absorbing medical films not only has good mechanical property, also has the initial stage anti-degradation capability of excellence.
The preparation method of a kind of absorbable biological medicinal membrane, comprises the following steps:
Step 1, by weight part, by polycaprolactone 3～10 parts, politef 2～7 parts, plant amylum 1～6 parts,
Chitosan 0.8～1.5 parts, paraffin 3～10 parts, glycerol 2～6 parts and barium stearate 1～7 parts are added to blender, and mixing is stirred
Mix, obtain material A；
Step 2, in parts by weight, forwards in reactor by step 1 gained material A, adds acrylamide 2～7 parts, poly-
Hydroxyethyl methylacrylate 1～5 parts, poly butylene succinate 3～8 parts, soybean lecithin 1～5 parts, citric acid 2～6
Part, Tissuemat E 3～7 parts, heated and stirred, it is down to room temperature, obtains material B；
Step 3, in parts by weight, adds antioxidant 0.5～1.2 parts in step 2 gained material B, and in twin screw
Extruder extruding pelletization, obtains pellet；
Step 4, by step 3 gained pellet by plastic film blowing machine blown film, to obtain final product.
Further, the one during plant amylum is corn starch, wheaten starch, potato starch or tapioca in step 1.
Further, in step 2, heating-up temperature is 60～70 DEG C, and speed of agitator is 600～800rpm, mixing time be 30～
50min。
Further, the one during antioxidant is antioxidant 1076, irgasfos 168 or antioxidant 1010 in step 3.
Further, in step 3, the condition of extruding pelletization is extrusion temperature 180～200 DEG C, screw speed 18～25rpm.
Further, in step 4 blown film condition be inflation film manufacturing machine barrel back segment temperature be 230～240 DEG C, barrel front-end temperature is
240～250 DEG C, blow-up ratio is 1.5～2.0, screw speed 25～35rpm, hauling speed 20～25m/min.
Further, also need in step 2 add gelatin 0.5～1.2 parts.
The absorbable biological medicinal membrane hot strength of the present invention is at 18MPa, and elongation at break is 12%, and vitrification point is 10
DEG C, not only there is good mechanical property, also there is the initial stage anti-degradation capability of excellence.
Detailed description of the invention
Embodiment 1
The preparation method of a kind of absorbable biological medicinal membrane, comprises the following steps:
Step 1, by weight part, by polycaprolactone 3 parts, politef 2 parts, plant amylum 1 part, chitosan
0.8 part, 3 parts of paraffin, glycerol 2 parts and barium stearate 1 part are added to blender, mix and blend, obtain material A；
Step 2, in parts by weight, forwards in reactor by step 1 gained material A, adds acrylamide 2 parts, poly-first
Base 2-(Acryloyloxy)ethanol 1 part, poly butylene succinate 3 parts, soybean lecithin 1 part, citric acid 2 parts, Tissuemat E 3
Part, heated and stirred, it is down to room temperature, obtains material B；
Step 3, in parts by weight, adds antioxidant 0.5 part in step 2 gained material B, and in double screw extruder
Extruding pelletization, obtains pellet；
Step 4, by step 3 gained pellet by plastic film blowing machine blown film, to obtain final product.
Wherein, in step 1, plant amylum is corn starch；In step 2, heating-up temperature is 60 DEG C, and speed of agitator is 800rpm,
Mixing time is 30min；In step 3, antioxidant is antioxidant 1076, and the condition of extruding pelletization is extrusion temperature 180 DEG C,
Screw speed 25rpm；In step 4 blown film condition be inflation film manufacturing machine barrel back segment temperature be 230 DEG C, barrel front-end temperature is 240
DEG C, blow-up ratio is 1.5, screw speed 25rpm, hauling speed 25m/min.
Embodiment 2
The preparation method of a kind of absorbable biological medicinal membrane, comprises the following steps:
Step 1, by weight part, by polycaprolactone 7 parts, politef 4 parts, plant amylum 2 parts, chitosan
1.2 parts, 7 parts of paraffin, glycerol 4 parts and barium stearate 5 parts are added to blender, mix and blend, obtain material A；
Step 2, in parts by weight, forwards in reactor by step 1 gained material A, adds acrylamide 6 parts, poly-first
Base 2-(Acryloyloxy)ethanol 4 parts, poly butylene succinate 5 parts, soybean lecithin 3 parts, citric acid 4 parts, Tissuemat E 6
Part, heated and stirred, it is down to room temperature, obtains material B；
Step 3, in parts by weight, adds antioxidant 0.9 part in step 2 gained material B, and in double screw extruder
Extruding pelletization, obtains pellet；
Step 4, by step 3 gained pellet by plastic film blowing machine blown film, to obtain final product.
Wherein, in step 1, plant amylum is potato starch；In step 2, heating-up temperature is 65 DEG C, and speed of agitator is 700rpm,
Mixing time is 40min；In step 3, antioxidant is antioxidant 1010, and the condition of extruding pelletization is extrusion temperature 190 DEG C,
Screw speed 20rpm；In step 4 blown film condition be inflation film manufacturing machine barrel back segment temperature be 240 DEG C, barrel front-end temperature is 250
DEG C, blow-up ratio is 1.8, screw speed 30rpm, hauling speed 20m/min.
Embodiment 3
The preparation method of a kind of absorbable biological medicinal membrane, comprises the following steps:
Step 1, by weight part, by polycaprolactone 9 parts, politef 6 parts, plant amylum 5 parts, chitosan
1.3 parts, 4 parts of paraffin, glycerol 5 parts and barium stearate 6 parts are added to blender, mix and blend, obtain material A；
Step 2, in parts by weight, forwards in reactor by step 1 gained material A, adds acrylamide 6 parts, poly-first
Base 2-(Acryloyloxy)ethanol 4 parts, poly butylene succinate 7 parts, soybean lecithin 3 parts, citric acid 5 parts, Tissuemat E 6
Part, heated and stirred, it is down to room temperature, obtains material B；
Step 3, in parts by weight, adds antioxidant 0.6 part in step 2 gained material B, and in double screw extruder
Extruding pelletization, obtains pellet；
Step 4, by step 3 gained pellet by plastic film blowing machine blown film, to obtain final product.
Wherein, in step 1, plant amylum is tapioca；In step 2, heating-up temperature is 70 DEG C, and speed of agitator is 600rpm,
Mixing time is 50min；In step 3, antioxidant is irgasfos 168, and the condition of extruding pelletization is extrusion temperature 200 DEG C,
Screw speed 18rpm；In step 4 blown film condition be inflation film manufacturing machine barrel back segment temperature be 230 DEG C, barrel front-end temperature is 250
DEG C, blow-up ratio is 2.0, screw speed 35rpm, hauling speed 20m/min.
Embodiment 4
The preparation method of a kind of absorbable biological medicinal membrane, comprises the following steps:
Step 1, by weight part, by polycaprolactone 3 parts, politef 2 parts, plant amylum 1 part, chitosan
0.8 part, 3 parts of paraffin, glycerol 2 parts and barium stearate 1 part are added to blender, mix and blend, obtain material A；
Step 2, in parts by weight, forwards in reactor by step 1 gained material A, adds acrylamide 2 parts, poly-first
Base 2-(Acryloyloxy)ethanol 1 part, poly butylene succinate 3 parts, soybean lecithin 1 part, citric acid 2 parts, Tissuemat E 3
Part, heated and stirred, it is down to room temperature, obtains material B；
Step 3, in parts by weight, adds antioxidant 0.5 part in step 2 gained material B, and in double screw extruder
Extruding pelletization, obtains pellet；
Step 4, by step 3 gained pellet by plastic film blowing machine blown film, to obtain final product.
Wherein, in step 1, plant amylum is corn starch；In step 2, heating-up temperature is 60 DEG C, and speed of agitator is 800rpm,
Mixing time is 30min；In step 3, antioxidant is antioxidant 1076, and the condition of extruding pelletization is extrusion temperature 180 DEG C,
Screw speed 25rpm；In step 4 blown film condition be inflation film manufacturing machine barrel back segment temperature be 2300 DEG C, barrel front-end temperature is 240
DEG C, blow-up ratio is 1.5, screw speed 25rpm, hauling speed 25m/min.
Embodiment 5
The present embodiment is with the difference of embodiment 2: also need in step 2 add gelatin 0.5～1.2 parts.
The preparation method of a kind of absorbable biological medicinal membrane, comprises the following steps:
Step 1, by weight part, by polycaprolactone 7 parts, politef 4 parts, plant amylum 2 parts, chitosan
1.2 parts, 7 parts of paraffin, glycerol 4 parts and barium stearate 5 parts are added to blender, mix and blend, obtain material A；
Step 2, in parts by weight, forwards in reactor by step 1 gained material A, adds acrylamide 6 parts, poly-first
Base 2-(Acryloyloxy)ethanol 4 parts, poly butylene succinate 5 parts, soybean lecithin 3 parts, citric acid 4 parts, Tissuemat E 6
Part, 0.5 part of gelatin, heated and stirred, it is down to room temperature, obtains material B；
Step 3, in parts by weight, adds antioxidant 0.9 part in step 2 gained material B, and in double screw extruder
Extruding pelletization, obtains pellet；
Step 4, by step 3 gained pellet by plastic film blowing machine blown film, to obtain final product.
Wherein, in step 1, plant amylum is potato starch；In step 2, heating-up temperature is 65 DEG C, and speed of agitator is 700rpm,
Mixing time is 40min；In step 3, antioxidant is antioxidant 1010, and the condition of extruding pelletization is extrusion temperature 190 DEG C,
Screw speed 20rpm；In step 4 blown film condition be inflation film manufacturing machine barrel back segment temperature be 240 DEG C, barrel front-end temperature is 250
DEG C, blow-up ratio is 1.8, screw speed 30rpm, hauling speed 20m/min.
Embodiment 1 to 5 gained medical films is carried out performance test, and result is as follows:
| Hot strength/MPa | Elongation at break/% | Vitrification point/DEG C | Degradation time (simulated body fluid)/d | |
| Embodiment 1 | 23 | 13 | 12 | 54 |
| Embodiment 2 | 18 | 16 | 14 | 49 |
| Embodiment 3 | 21 | 14 | 10 | 45 |
| Embodiment 4 | 20 | 12 | 11 | 50 |
| Embodiment 5 | 34 | 23 | 13 | 52 |
As seen from the above table, the absorbable biological medicinal membrane hot strength of the present invention is at 18MPa, and elongation at break is 12%, glass
Glass temperature is 10 DEG C, and the degradation time in SBF (simulated body fluid) is 45d.Embodiment 1 to 4 gained membrane material exists
SBF (simulated body fluid) soaks and within 25 days, i.e. starts to corrode, and membrane material 32 talent of embodiment 5 starts corrosion, this
Illustrate that in embodiment 5, the addition of gelatin is possible not only to improve the mechanical property of membrane material, moreover it is possible to the initial stage anti-fall of reinforcing membrane material
Solution ability.
Claims (7)
1. the preparation method of an absorbable biological medicinal membrane, it is characterised in that: comprise the following steps:
Step 1, by weight part, is added to blender, mix and blend by polycaprolactone 3～10 parts, politef 2～7 parts, plant amylum 1～6 parts, chitosan 0.8～1.5 parts, paraffin 3～10 parts, glycerol 2～6 parts and barium stearate 1～7 parts, obtains material A；
Step 2, in parts by weight, step 1 gained material A is forwarded in reactor, add acrylamide 2～7 parts, poly hydroxy ethyl acrylate 1～5 parts, poly butylene succinate 3～8 parts, soybean lecithin 1～5 parts, citric acid 2～6 parts, Tissuemat E 3～7 parts, heated and stirred, it is down to room temperature, obtains material B；
Step 3, in parts by weight, adds antioxidant 0.5～1.2 parts in step 2 gained material B, and in double screw extruder extruding pelletization, obtains pellet；
Step 4, by step 3 gained pellet by plastic film blowing machine blown film, to obtain final product.
The preparation method of absorbable biological medicinal membrane the most according to claim 1, it is characterised in that: the one during plant amylum is corn starch, wheaten starch, potato starch or tapioca in step 1.
The preparation method of absorbable biological medicinal membrane the most according to claim 1, it is characterised in that: in step 2, heating-up temperature is 60～70 DEG C, and speed of agitator is 600～800rpm, and mixing time is 30～50min.
The preparation method of absorbable biological medicinal membrane the most according to claim 1, it is characterised in that: the one during antioxidant is antioxidant 1076, irgasfos 168 or antioxidant 1010 in step 3.
The preparation method of absorbable biological medicinal membrane the most according to claim 1, it is characterised in that: in step 3, the condition of extruding pelletization is extrusion temperature 180～200 DEG C, screw speed 18～25rpm.
The preparation method of absorbable biological medicinal membrane the most according to claim 1, it is characterized in that: in step 4 blown film condition be inflation film manufacturing machine barrel back segment temperature be 230～240 DEG C, barrel front-end temperature is 240～250 DEG C, blow-up ratio is 1.5～2.0, screw speed 25～35rpm, hauling speed 20～25m/min.
The preparation method of absorbable biological medicinal membrane the most according to claim 1, it is characterised in that: also need in step 2 add gelatin 0.5～1.2 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610202119.6A CN105854089A (en) | 2016-03-31 | 2016-03-31 | Method for preparing absorbable biomedical film |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610202119.6A CN105854089A (en) | 2016-03-31 | 2016-03-31 | Method for preparing absorbable biomedical film |
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| CN201610202119.6A Pending CN105854089A (en) | 2016-03-31 | 2016-03-31 | Method for preparing absorbable biomedical film |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111282141A (en) * | 2020-03-05 | 2020-06-16 | 安徽健邦宏扬医疗科技有限公司 | Disposable injection type cervical dilator |
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|---|---|---|---|---|
| CN101381480A (en) * | 2008-10-23 | 2009-03-11 | 梁二宝 | Medical high molecular compound complete biodegradable plastics |
| CN101623517A (en) * | 2009-08-11 | 2010-01-13 | 广州迈普再生医学科技有限公司 | Medical anti-sticking membrane and preparation method thereof |
| CN104371171A (en) * | 2014-11-07 | 2015-02-25 | 苏州维泰生物技术有限公司 | Medical high-temperature-resistant antistatic film and preparation method thereof |
| CN105111561A (en) * | 2015-08-27 | 2015-12-02 | 江苏蓝湾生物科技有限公司 | Preparation method of medical anti-atomization film |
| CN105131474A (en) * | 2015-09-23 | 2015-12-09 | 江苏蓝湾生物科技有限公司 | Preparation method of medical film having sterilizing function |
-
2016
- 2016-03-31 CN CN201610202119.6A patent/CN105854089A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101381480A (en) * | 2008-10-23 | 2009-03-11 | 梁二宝 | Medical high molecular compound complete biodegradable plastics |
| CN101623517A (en) * | 2009-08-11 | 2010-01-13 | 广州迈普再生医学科技有限公司 | Medical anti-sticking membrane and preparation method thereof |
| CN104371171A (en) * | 2014-11-07 | 2015-02-25 | 苏州维泰生物技术有限公司 | Medical high-temperature-resistant antistatic film and preparation method thereof |
| CN105111561A (en) * | 2015-08-27 | 2015-12-02 | 江苏蓝湾生物科技有限公司 | Preparation method of medical anti-atomization film |
| CN105131474A (en) * | 2015-09-23 | 2015-12-09 | 江苏蓝湾生物科技有限公司 | Preparation method of medical film having sterilizing function |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111282141A (en) * | 2020-03-05 | 2020-06-16 | 安徽健邦宏扬医疗科技有限公司 | Disposable injection type cervical dilator |
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