CN101381480A - Medical high molecular compound complete biodegradable plastics - Google Patents
Medical high molecular compound complete biodegradable plastics Download PDFInfo
- Publication number
- CN101381480A CN101381480A CNA2008101581618A CN200810158161A CN101381480A CN 101381480 A CN101381480 A CN 101381480A CN A2008101581618 A CNA2008101581618 A CN A2008101581618A CN 200810158161 A CN200810158161 A CN 200810158161A CN 101381480 A CN101381480 A CN 101381480A
- Authority
- CN
- China
- Prior art keywords
- medical
- biodegradable plastics
- molecular compound
- high molecular
- complete biodegradable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/04—Particle-shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/92—Measuring, controlling or regulating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2948/00—Indexing scheme relating to extrusion moulding
- B29C2948/92—Measuring, controlling or regulating
- B29C2948/92504—Controlled parameter
- B29C2948/92704—Temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2948/00—Indexing scheme relating to extrusion moulding
- B29C2948/92—Measuring, controlling or regulating
- B29C2948/92819—Location or phase of control
- B29C2948/92857—Extrusion unit
- B29C2948/92876—Feeding, melting, plasticising or pumping zones, e.g. the melt itself
- B29C2948/92895—Barrel or housing
Abstract
The invention discloses a method for producing macromolecular compound medical fully biodegradable plastics. The macromolecular compound medical fully biodegradable plastics are prepared by adoption of amylase as a base material, addition of an additive and an auxiliary agent into the amylase, cold and hot mixing through a high-speed mixer, modification and plasticization of the amylase, and kneading and extruding granulation. The method can be widely applied to medical film materials, medicine package, medical appliances, medical fiber, medical catheters, infusion containers, medicine bottles, trays, medical polymer microspheres and so on; the biocompatibility of products is good; and the products are fully biodegradable after being used, and are safe to use.
Description
Technical field
The present invention relates to the production method in medical macromolecular materials field, particularly a kind of medical high molecular compound complete biodegradable plastics.
Prior art
Our medical macromolecular materials of country's use are various in style at present, and medical polyester, medical gelatin, medical fibre, medical polyethylene, polypropylene for medical article, medical polystyrene, polypropylene for medical article nitrile, medical PVA etc. are arranged.Medical macromolecular materials are divided into three classes, and a class is a surface contact class; Two classes are of short duration contact class; Three classes are implant into body and blood plasma contact material.Medical macromolecular materials mostly are the plastics class, and specification of quality is extremely tight, should reach biocompatibility and reach nontoxic, clean, no anaphylaxis, non-carcinogenesis again, do not produce thrombus, do not destroy hemocyte and change plasma protein composition etc.To medical macromolecular materials, can use by the Biological Detection and the test of necessity according to different service requirementss.
Above-mentioned medical macromolecular materials, majority is made for petrochemical complex plastics and synthetic plastics.Though medical macromolecular materials use the petrochemical complex plastics comparatively safe but be not to be perfectly safe.Malpractice all appearred because of medical macromolecular materials are defective as disposable injection bottle, biological suture line, baby bottles etc.
Summary of the invention
The present invention is some defectives that exist for the medical macromolecular materials that overcome present use, and a kind of production method that contacts the medical high molecular compound complete biodegradable plastics that is perfectly safe with human body is provided:
The present invention is achieved in that with corn amylose starch, polyvinyl alcohol be main raw material, adds phase solvent, additive, auxiliary agent, by high-speed mixing, knead, a kind of medical high molecular compound complete biodegradable plastics particle that extruding pelletization is made.
Its weight proportion is:
Straight chain corn starch 33-40%
Carboxamide 4-6%
Edible glycerol 13-16%
Compatilizer 5-9%
Polyvinyl alcohol 10-15%
Polycaprolactone 30-33%
Polyethylene wax 3-5%
Gelatin 1-3%
Chitosan 1-3%
The production method is altogether:
1, by formula ratio straight chain corn starch is joined and have heat and mix in the high-speed mixer of cold mixed function, low speed mixing 3-5 minutes, the water ratio that detects straight chain corn starch adds edible glycerol low speed mixing less than till 3%.To mixing machine, during material temperature rise to 80 ℃, add carboxamide, compatilizer, polyethylene wax, continue low speed mixing.When material temperature rise to 100 ℃, carry out cold mixing after adding polyvinyl alcohol, polycaprolactone, gelatin, chitosan, the material temperature is progressively descended, during material temperature drop to 40 ℃, low speed heats up and mixes again, when the material temperature rises to 100 ℃, changes high-speed mixing, to expecting that temperature reaches 120 ℃, stop to mix, at once blowing.Emit material at normal temperatures (20 ℃) left standstill 24 hours, be compound.
2, the compound that will leave standstill is sent into S type kneading machine, kneads 30 minutes at a high speed.
3, the material of will kneading is sent in the special-purpose two spiral shell material forcing machines of starch plastic, and control material temperature adopts air-cooled fervent granulation at 150-165 ℃, promptly makes qualified medical high molecular compound complete biodegradable plastics.
The beneficial effect that the present invention produces is: the complete biology of medical high molecular compound falls degradative plastics and is used for food product pack; medical packaging and contact human body parts use and are perfectly safe; do not contain harmful material; particularly curable product is disposable more; use the back discontinued product; fully biodegradable, the protection environment has solved " white pollution " problem after the curable product use is discarded.
Embodiment
1, straight chain corn starch is 3.3 kilograms, 0.4 kilogram of carboxamide, 1.3 kilograms of edible glycerol, 0.5 kilogram of compatilizer, 3 kilograms of polycaprolactones, 1 kilogram of polyvinyl alcohol, 0.3 kilogram of polyethylene wax, 0.1 kilogram in gelatin, 0.1 kilogram of chitosan; Earlier straight chain corn starch is put into the miniature high-speed mixing machine, low speed mixing 3-5 minutes detects the straight chain corn starch water ratio and is lower than at 3% o'clock, add edible glycerol low speed mixing, when expecting that temperature reaches 80 ℃, add carboxamide, compatilizer, polyethylene wax, continue low speed mixing.When material temperature rise to 100 ℃, carry out cold mixing after adding polyvinyl alcohol, pla-pcl, gelatin, chitosan.When material temperature drop to 40 ℃, heat up again and mix, during material temperature rise to 100 ℃, change high-speed mixing, when expecting that temperature reaches 120 ℃, stop to mix blowing at once.At room temperature left standstill 24 hours; To leave standstill material and send into kneading machine, knead 30 minutes at a high speed; The material of will kneading is sent in the special-purpose twin screw extruder of starch plastics, and 150-165 ℃ of temperature controls adopt air-cooled fervent granulation, promptly make medical high molecular compound complete biodegradable plastics.
2, straight chain corn starch is to adopt 400 orders above edible cornstarch and content 25% above n-butanol aqueous solution stirring and dissolving to make.Be dissolved in butanol solution for the side chain W-Gum, be insoluble to butanol solution and sedimentaryly be straight chain corn starch.The ratio of edible corn starch and butanol solution is 1:3, and butanol solution can use repeatedly.
3, the carboxamide in the prescription is a nitrogen content greater than 46% product.
4, the edible glycerol in the prescription is food grade saponification glycerine.
5, the compatilizer in the prescription is EVOH, 140-150 ℃ of fusing points, and ethylene content is at 30-40% product.
6, the pla-pcl in the prescription is aliphatics H7, the granulated product of molecular weight more than 70000.
7, the polyvinyl alcohol in the prescription requires alcoholysis degree to reach 99.7-100% water tolerance resin.
8, the polyethylene wax in the prescription is TLIJ-1 type, the product of viscosity-average molecular weight 6000-7000.
Claims (2)
1, a kind of medical high molecular compound complete biodegradable plastics, be to be main raw material by food grade straight chain corn starch, polycaprolactone, polyvinyl alcohol, add compatilizer, edible glycerol, carboxamide, gelatin, chitosan, by a kind of medical macromolecular materials that high temperature and high speed mixes, kneads, extruding pelletization is made.
2, medical high molecular compound complete biodegradable plastics, its technical characterictic is:
1. medical high molecular compound complete biodegradable plastics adopts following prescription:
Amylose tri 3-40%
Carboxamide 4-6%
Edible glycerol 13-16%
Compatilizer 5-9%
Polyvinyl alcohol 10-15%
Polycaprolactone 30-33%
Polyethylene wax 3-5%
Gelatin 1-3%
Chitosan 1-3%
2. the production method of medical high molecular compound complete biodegradable plastics is:
Straight chain corn starch is joined in the high-speed mixer with the mixed cold mixed function of heat by formula ratio, low speed mixing 3-5 minute, detect the straight chain corn starch water ratio less than 3% o'clock, add edible glycerol low speed mixing, to mixing machine during material temperature rise to 80 ℃, add carboxamide, compatilizer, polyethylene wax continues low speed mixing, during material temperature rise to 100 ℃, add polyvinyl alcohol, polycaprolactone, gelatin, carry out cold mixing behind the chitosan, the material temperature is progressively descended, when material temperature drop to 40 ℃, low speed heats up and mixes again, when the material temperature rises to 100 ℃, changes high-speed mixing, stop to mix when material temperature rise to 120 ℃, blowing at room temperature left standstill 24 hours at once; The compound that leaves standstill is sent into S type kneading machine, kneaded 30 minutes at a high speed; The material of will kneading is sent in the special-purpose twin screw extruder of starch plastics, and temperature control 150-165 ℃, adopt air-cooled fervent granulation, promptly make medical high molecular compound complete biodegradable plastics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101581618A CN101381480A (en) | 2008-10-23 | 2008-10-23 | Medical high molecular compound complete biodegradable plastics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101581618A CN101381480A (en) | 2008-10-23 | 2008-10-23 | Medical high molecular compound complete biodegradable plastics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101381480A true CN101381480A (en) | 2009-03-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101581618A Pending CN101381480A (en) | 2008-10-23 | 2008-10-23 | Medical high molecular compound complete biodegradable plastics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101381480A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102181077A (en) * | 2011-03-14 | 2011-09-14 | 珠海市比格尔生物科技有限公司 | Fully biodegradable film meeting EN13432 standard and preparation method thereof |
| CN103319813A (en) * | 2013-07-02 | 2013-09-25 | 河南惠强新能源材料科技有限公司 | Composite material for medicinal tray and preparation method thereof |
| CN105694478A (en) * | 2016-03-31 | 2016-06-22 | 青岛百瑞吉生物工程有限公司 | Preparation method of degradable biological medical composite material |
| CN105754150A (en) * | 2016-04-08 | 2016-07-13 | 苏州市鼎立包装有限公司 | Degradable medical packaging material and preparation method thereof |
| CN105854089A (en) * | 2016-03-31 | 2016-08-17 | 青岛百瑞吉生物工程有限公司 | Method for preparing absorbable biomedical film |
| CN105885116A (en) * | 2016-06-24 | 2016-08-24 | 安徽德琳环保发展（集团）有限公司 | Polylactic acid-caprolactone-starch extrusion blown film and preparation method thereof |
| CN106065090A (en) * | 2016-08-22 | 2016-11-02 | 太湖华强科技有限公司 | Caprolactone starch degradable thin film that a kind of polyvinyl alcohol strengthens and preparation method thereof |
| CN106317473A (en) * | 2016-08-22 | 2017-01-11 | 太湖华强科技有限公司 | Temperature-resistant caprolactone-grafted starch degradable film and preparation method thereof |
| CN106317474A (en) * | 2016-08-22 | 2017-01-11 | 太湖华强科技有限公司 | High-breathability caprolactone grafted starch degradable thin film and preparation method thereof |
| CN107501624A (en) * | 2017-09-14 | 2017-12-22 | 南通荣成医药化工有限公司 | A kind of pharmaceutical packaging bag |
-
2008
- 2008-10-23 CN CNA2008101581618A patent/CN101381480A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102181077A (en) * | 2011-03-14 | 2011-09-14 | 珠海市比格尔生物科技有限公司 | Fully biodegradable film meeting EN13432 standard and preparation method thereof |
| CN103319813A (en) * | 2013-07-02 | 2013-09-25 | 河南惠强新能源材料科技有限公司 | Composite material for medicinal tray and preparation method thereof |
| CN103319813B (en) * | 2013-07-02 | 2016-05-04 | 河南惠强新能源材料科技有限公司 | A kind of composite and preparation method thereof for medicinal pallet |
| CN105694478A (en) * | 2016-03-31 | 2016-06-22 | 青岛百瑞吉生物工程有限公司 | Preparation method of degradable biological medical composite material |
| CN105854089A (en) * | 2016-03-31 | 2016-08-17 | 青岛百瑞吉生物工程有限公司 | Method for preparing absorbable biomedical film |
| CN105754150A (en) * | 2016-04-08 | 2016-07-13 | 苏州市鼎立包装有限公司 | Degradable medical packaging material and preparation method thereof |
| CN105885116A (en) * | 2016-06-24 | 2016-08-24 | 安徽德琳环保发展（集团）有限公司 | Polylactic acid-caprolactone-starch extrusion blown film and preparation method thereof |
| CN106065090A (en) * | 2016-08-22 | 2016-11-02 | 太湖华强科技有限公司 | Caprolactone starch degradable thin film that a kind of polyvinyl alcohol strengthens and preparation method thereof |
| CN106317473A (en) * | 2016-08-22 | 2017-01-11 | 太湖华强科技有限公司 | Temperature-resistant caprolactone-grafted starch degradable film and preparation method thereof |
| CN106317474A (en) * | 2016-08-22 | 2017-01-11 | 太湖华强科技有限公司 | High-breathability caprolactone grafted starch degradable thin film and preparation method thereof |
| CN107501624A (en) * | 2017-09-14 | 2017-12-22 | 南通荣成医药化工有限公司 | A kind of pharmaceutical packaging bag |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090311 |