CN105853997A - Medicine composition used for treating osteomalacia - Google Patents
Medicine composition used for treating osteomalacia Download PDFInfo
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- CN105853997A CN105853997A CN201610204556.1A CN201610204556A CN105853997A CN 105853997 A CN105853997 A CN 105853997A CN 201610204556 A CN201610204556 A CN 201610204556A CN 105853997 A CN105853997 A CN 105853997A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
The invention relates to the field of Chinese patent medicines and in particular relates to a medicine composition used for treating osteomalacia. The medicine composition is characterized by being prepared from the following raw materials: 200-400U of natural vitamin D3, 4-8mg of natural vitamin A and 50g of whey protein. The medicine composition has the effect of solving the technical problem in existing main calcium supplementary treatment that absorption of related medicines is insufficient, and acts on wounded parts via mutual coordination of vitamin A, vitamin D and whey protein. The technical innovation points are as follows: a nano-scale ultra-fine process is applied in raw material mixing, and better absorption can be achieved by using a 80 DEG C constant temperature drying method to ensure that trace elements in the raw materials, such as vitamins, maintain the best biological activities. The medicine composition has the characteristics of reliable curative effect, quickness in effect taking, no side effect, and the like.
Description
Technical field
The present invention relates to the compound preparation that original new drug field is new, a kind of drug regimen for treating osteomalacia.
Background technology
Osteomalacia all has at different age brackets, is concentrated mainly on children and middle-aged and elderly people colony.Child mainly shows as rickets.Teenager mainly shows as O shape lower limb etc., and middle-aged and elderly people mainly shows as osteomalacia, osteoid tissue hypertrophy, textured bone.The cause of disease mostly is vitamin D and calcium, phosphorus lack.
On market a lot of for the product replenished the calcium, it is mainly composed of calcium carbonate, although price is cheap, but absorbance is the highest, calcium carbonate human body the most only absorbs 15 ~ 21%, it is impossible to effectively treating the comprehensive complication of amyotrophy, the joint wear etc. brought by osteomalacia, osteomalacia severe one has pain and tenderness at the near-end position of spinal column, pelvis and extremity, muscle weakness is unable, is even duck step during action.Not having obvious wound also to there will be fracture, occurring most frequently fracture site is neck of femur, pubis branch and rib.Because of the multiple tenderness of vertebral body, height can shorten.
Natural complex D3 and lactalbumin all can effectively supplement the various nutrition needed for skeleton growth, easier absorption more more scientific than traditional calcium carbonate.Natural vitamin A also possesses biosynthesis and the differentiation of osteocyte promoting protein.But there is presently no a kind of medicine by three's reasonable compatibility, with compound preparation form of therapy osteomalacia, all with folk prescription form or supplementary form, dosage is less, it is impossible to reach the purpose cured.
Summary of the invention
It is an object of the invention to provide a kind of drug regimen for treating osteomalacia, it solves the technical problems such as the related drugs incomplete absorption that occurs in above-mentioned existing main calcium supplementary treatment, mutually acts synergistically on affected part by vitamin A, vitamin D and lactalbumin.Innovation point is to use nano level superfine technique to apply in raw material mixes, by 80 degree of seasoning modes of constant temperature, ensure that the trace element such as the vitamin in raw material keep optimal biological activity, can realize absorbing more preferably have that curative effect is reliable, instant effect, the feature such as have no side effect.
For solving above-mentioned technical problem, the present invention is achieved in that
A kind of drug regimen for treating osteomalacia, it is characterised in that: it is made up of following raw material: natural complex D3 200U ~ 400U, natural vitamin A 4mg ~ 8mg, lactalbumin 50 grams.
The described drug regimen for treating osteomalacia, it is characterized in that: its preparation method is, in proportion by natural complex D3, natural vitamin A, mix with lactalbumin powder, selecting the average diameter nano level superfine breaking drier processing less than 10 μm, 80 degree of constant temperature 15 minutes also forms powder.
Detailed description of the invention
It is further described the present invention below in conjunction with embodiment.
Embodiment 1
Raw material: natural complex D3 400U, natural vitamin A 4mg, lactalbumin 50 grams.
Ratio, by natural complex D3, natural vitamin A, mixes with lactalbumin powder, selects the average diameter nano level superfine breaking drier processing less than 10 μm, and 80 degree of constant temperature 15 minutes also forms powder.
Case 1: female Lee, 18 years old, serves as and joins dance work, and every day will go to the village fair, and the degeneration change that symptom of aching, cartilage injury cause occurs in result knee, and including the swelling of cartilage, fragmentation, comes off and the pathological changes such as corrosion and the series of symptoms that produces.Coordinate the measures such as affected part arthrodesis, use the present embodiment 1, brew with warm water and take, three times on the one.Under vitamin D3 lactoferrin in lactalbumin and vitamin A regulation, erythrocyte, hematochrome and oxygen transportation maintained and strengthened, osteoblast and chondrocyte proliferation promoted, after one week, the level of plasma calcium and blood plasma phosphorus reaches degree of saturation, constantly promotes cartilage-derived growth and skeleton calcification.After two weeks, osteomalacia is controlled.After 1 month, cartilaginous lesion site heals again, with consolidating again one month, thoroughly fully recovers, so far no recurrence.
Embodiment 2
Raw material: natural complex D3 300U, natural vitamin A 8mg, lactalbumin 50 grams.
Ratio, by natural complex D3, natural vitamin A, mixes with lactalbumin powder, selects the average diameter nano level superfine breaking drier processing less than 10 μm, and 80 degree of constant temperature 15 minutes also forms powder.
Case 2: Zhang, 15 years old, Calf muscle powerlessness, knee osteomalacia, slight O type lower limb.Cooperation affected part arthrodesis is orthopedic waits measure, uses the present embodiment 2, brews with warm water and take, three times on the one.After one week, knee fixes orthopedic place, the orthopedic Guan Bi of cartilage tissue growth, completes skeleton calcification simultaneously.Removing orthopedic fixator after two weeks, osteomalacia is controlled, and O type lower limb is corrected.After 1 month, knee cartilage tissue Slant Rectify is as good as with normal person, with consolidating again one month, thoroughly fully recovers, and is also strengthened with whole body cartilage, the no recurrence so far of knee affected part.
Embodiment 3
Raw material: natural complex D3 200U, natural vitamin A 6mg, lactalbumin 50 grams.
Ratio, by natural complex D3, natural vitamin A, mixes with lactalbumin powder, selects the average diameter nano level superfine breaking drier processing less than 10 μm, and 80 degree of constant temperature 15 minutes also forms powder.
Case 3: Shen female, 52 years old, climacteric, diet calcium supplemented deficiency, and blood calcium, serium inorganic phosphorus lowly cause osteoporosis, soreness of the waist and knees, muscle weakness.Use the present embodiment 3, brew with warm water and take, three times on the one.After one week, blood calcium, serium inorganic phosphorus value recover normal, and bone density increases.After two weeks, muscle is strong, and serum calcium, phosphorus and alkaline phosphatase levels are normal.After 1 month, primary osteoporosis is modal to be reduced with lumbago and backache symptom.With consolidating again one month, thoroughly fully recover, also strengthened with whole body cartilage joint.
The pharmacology analysis of product of the present invention:
1, natural complex D3: cholecalciferol, is a kind of from the biological preparation of extraction in animal livers, and physiological function is to promote intestinal calcium absorption, and induction sclerotin calcium phosphorus is calm；Promote growth and skeleton calcification, promote that tooth perfects；Increased the absorption of phosphorus by intestinal wall, and increased the re-absorption of phosphorus by renal tubules；Maintain the normal level of citrate in blood；Prevent aminoacid from being lost by kidney.
2, natural vitamin A: extract essentially from cod-liver oil, belong to fatsoluble vitamin with vitamin D；Promote biosynthesis and the differentiation of osteocyte of protein；. promote bone growth, help dental growth, regeneration.
3, lactalbumin: be referred to as the king of albumen, be from milk extract a kind of protein, have be of high nutritive value, absorption easy to digest, containing the features such as various active composition, one of human body high quality protein supplement being well recognized as.Containing abundant beta lactoglobulin, alpha-lactalbumin, immunoglobulin, lactoferrin, branched-chain amino acid etc., promote cell growth, promote osteoblast and the function of chondrocyte proliferation, and its physiology content can be increased, reduce bone mineral and run off and the risk of fracture.
It is an advantage of the current invention that the vitamin raw materials that invention is used meets Pharmacopoeia of the People's Republic of China regulation, safety of medicine is reliable.Particularly produce under nano level superfine disintegrating process is in isoperibol, it is ensured that the biological activity that the trace element such as vitamin are optimal.Secondly, after vitamin and lactalbumin compound compatibility, change the feature that tradition folk prescription dosage form absorbance is low, improve absorption efficiency, add healing speed.Such as fat-soluble A and D, owing to cannot directly enter blood by intestinal absorption, result in conventional suction extremely inefficient.And after lactalbumin compatibility, while trophic factors in egg albumen powder promotes intestinal absorption protein, add vitamin A and D absorption efficiency, vitamin A and D is made to rapidly enter lymphatic circulation, it is stored in internal, blood system acts on jointly with lymphsystem, facilitates cartilage-derived growth to improve with bone density.There is treatment adult bone malacosis, rickets that prevention youngsters and children is deficient in vitamin D and is formed, O shape lower limb etc., have that curative effect is reliable, instant effect, the feature such as have no side effect.
It is only presently preferred embodiments of the present invention in sum, is not used for limiting the practical range of the present invention.The most all equivalence changes made according to the content of scope of the present invention patent and modification, all should be the technology category of the present invention.
Claims (2)
1. the drug regimen being used for treating osteomalacia, it is characterised in that: it is made up of following raw material: natural complex D3
200U ~ 400U, natural vitamin A
4mg ~ 8mg, lactalbumin 50 grams.
2.According to claim 1The described drug regimen for treating osteomalacia, it is characterized in that: its preparation method is, in proportion by natural complex D3, natural vitamin A, mix with lactalbumin powder, selecting the average diameter nano level superfine breaking drier processing less than 10 μm, 80 degree of constant temperature 15 minutes also forms powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610204556.1A CN105853997A (en) | 2016-04-05 | 2016-04-05 | Medicine composition used for treating osteomalacia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610204556.1A CN105853997A (en) | 2016-04-05 | 2016-04-05 | Medicine composition used for treating osteomalacia |
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| CN105853997A true CN105853997A (en) | 2016-08-17 |
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| CN201610204556.1A Pending CN105853997A (en) | 2016-04-05 | 2016-04-05 | Medicine composition used for treating osteomalacia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116491657A (en) * | 2023-03-17 | 2023-07-28 | 笛卡尔药业(哈尔滨)有限公司 | Calcium preparation containing vitamin D and preparation method thereof |
-
2016
- 2016-04-05 CN CN201610204556.1A patent/CN105853997A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116491657A (en) * | 2023-03-17 | 2023-07-28 | 笛卡尔药业(哈尔滨)有限公司 | Calcium preparation containing vitamin D and preparation method thereof |
| CN116491657B (en) * | 2023-03-17 | 2024-05-28 | 笛卡尔药业(哈尔滨)有限公司 | Calcium preparation containing vitamin D and preparation method thereof |
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Application publication date: 20160817 |