CN105853881A

CN105853881A - Medicine capable of being used for treating virus hepatitis and preparation method thereof

Info

Publication number: CN105853881A
Application number: CN201610292059.1A
Authority: CN
Inventors: 张蛟
Original assignee: Chengdu Yishengke Biotechnology Co Ltd
Current assignee: Chengdu Yishengke Biotechnology Co Ltd
Priority date: 2016-05-05
Filing date: 2016-05-05
Publication date: 2016-08-17

Abstract

The invention discloses a medicine capable of being used for treating virus hepatitis and a preparation method thereof. The medicine is prepared from medicine terminalia fruits, radix rehmanniae preparata, aconitum pulchellum, aconitum tanguticum, aconitum tangutcum, herba dracocephali tangutici, calculus bovis, natural calculus bovis, fel ursi, white sandalwood, red sandalwood, agilawood, musk, iron powder, silver ash, copper ash, vermiculite, tabasheer, tophus, red coral, pearl, lapis lazuli, vermilion, potassium nitrate, crabs, pokeberry roots, corydalis impatiens, trogopterus dung paste, rhizoma corydalis, emblic leafflower fruits, saffron crocus, safflower, pomegranate seeds, clove, black borneol, Amomum tsao-ko, Swertia chirayita, common vladimiria roots, herpetospermum seeds, mango seeds, semen holarrhenae, fructus piperis longi, Chinese parsley, the roots of kudzu vine, cassia seeds, myrsine semiserrata wall, myrrh, phlomis betonicoides, meconopsis, Coptes teeta, Myricariaprostrata, birthwort, jasmine and sugar. The medicine has the advantages of being stable in quality, safe to use, convenient to take, rapid in curative effect, high in curative effect and low in recurrence rate and has the functions of clearing heat, promoting diuresis, soothing the liver, regulating the spleen, dispersing blood stasis and removing stasis.

Description

A kind of medicine that can be used for treatment virus hepatitis and preparation method thereof

Technical field

The present invention relates to biological pharmacy technical field, specifically, be a kind of medicine that can be used for treating virus hepatitis And preparation method thereof.

Background technology

Virus hepatitis is a kind of infectious disease based on hepatic disease caused by multiple hepatitis viruse.Clinically with food Be intended to go down, feel sick, epigastric discomfort, pain in the hepatic region, weak for main performance.Some patients can have jaundice heating and hepatomegaly with liver Functional lesion.Some patient can chronicity, even develop into cirrhosis, minority can develop into liver cancer.

The Etiologic Classification of virus hepatitis, the most putative have first, second, third, fourth, penta 5 kinds of hepatitis viruses, point Not writing HAV, HBV, HCV, HDV, HEV, in addition to hepatitis type B virus is DNA virus, remaining is RNA virus.Own type hepatitis Once had been reported that, but pathogen separation was unsuccessful so far.In recent years report, belong to the hepatovirus and the TTV of single stranded DNA and people in heptan of flavivirus The relation of class hepatitis remains in dispute.

Clinical manifestation

1. oxyhepatitis

Be divided into acute icteric hepatitis and acute anicteric hepatitis, incubation period between 15～45 days, average 25 days, total course of disease 2～4 months.

(1) have pre-icterus stage chilly, heating, weak, lose the appetite, feel sick, detest oil, abdominal discomfort, pain in the hepatic region, urine look Gradually deepen, average 5～7 days of current period.

(2) stage of icterus heat is moved back, sclera, xanthochromia, and jaundice occurs and subjective symptoms has taken a turn for the better, and hepatomegaly is accompanied tenderness, kowtowed Hit pain, splenomegaly that some patients is slight, current period 2～6 weeks.

(3) convalescence jaundice gradually disappears, and symptom alleviates so that disappearing, and liver spleen recovers normal, and liver function is gradually recovered, Current period continues 2 thoughtful 4 months, average 1 month.

2. chronic hepatitis

Previously having B-mode, the third type, hepatitis D or HBsAg is that unit carried history or the oxyhepatitis course of disease more than 6 months, and current Still there are hepatitis symptom, sign and dysfunction of liver person, chronic hepatitis can be diagnosed as.Common sympton is weak, general malaise, food Be intended to go down, uncomfortable liver area or pain, abdominal distension, low-heat, sign is dim complexion, icteric sclera, can have spider angioma or liver palms, liver Greatly, quality is medium or sense of fulfillment, kowtows pain, splenomegaly severe patient, can have jaundice intensification, seroperitoneum, edema of lower extremity, hemorrhagic tendency And hepatic encephalopathy, can be divided into according to the liver damage level clinic:

(1) the slight state of an illness is relatively light, though symptom is inconspicuous or has a symptom and sign, but only 1～2 mile abnormality person of biochemical indicator.

(2) moderate symptoms, sign, occupy person between slight and severe.Liver function has abnormal change.

(3) severe has obvious or lasting hepatitis symptom, as weak, receive poor, abdominal distension, loose stool etc., can be with hepatopathy face Appearance, liver palms, spider angioma or hepatosplenomegaly, and get rid of other reasons and without portal hypertension person.Laboratory examination serum, Gu Bingzhuan Ammonia enzyme raises repeatedly or persistently: albumin lowers or A/g is unit abnormal proportion, and gamma globulin is significantly raised, all albumin ≤ 32g is unit/L, bilirubin > 85.5 μm ol/L, Prothrombin activity 60%～40%, three detections there is a person, i.e. Diagnosable for severely chronic hepatitis.

3. heavy type hepatitis

(1) acute severe hepatitis onset is anxious, and progress is fast, and jaundice is deep, and liver is little.In rising 10 days after being ill, psychoneural occurs rapidly Symptom, hemorrhagic tendency substantially and may occur in which that liver is smelly, seroperitoneum, hepatorenal syndrome, Prothrombin activity are got rid of less than 40% Other reasons person, cholesterol is low, and liver function is substantially abnormal.

(2) subacute severe hepatitis is after onset 10 days, still have extremely the most weak, receive poor, severe jaundice (bilirubin > 171 μm ol/L), abdominal distension seroperitoneum formed, have obvious bleeding, general liver to reduce and do not highlight more, hepatic encephalopathy is common Seriously damage in later stage liver function: Serum ALT raises or raises inconspicuous, and total bilirubin is significantly raised i.e.: courage enzyme separates, A/ G is that unit ratio is inverted, and gamma globulin raises, prolonged prothrombin, Prothrombin activity < 40%.

(3) chronic severe hepatitis has chronic hepatitis liver cirrhosis or has HBsAg carriers history, iconography, abdomen Chamber spectroscopy or liver puncture support chronic hepatitis shower, and occur that the clinical manifestation of subacute hepatitis sequestrans and laboratory change For chronic severe hepatitis.

4. cholestatic hepatitis

Onset is similar to acute icteric hepatitis, but subjective symptoms is the lightest, has obvious hepatomegaly, pruitus, stool look shallow, serum Alkaline phosphatase, γ-transpeptidase, cholesterol all have and substantially increase, and jaundice is deep, and bilirubin raises directly to increase, and turns ammonia Enzyme ascensional range is little, and prothrombin time and Prothrombin activity are normal.Lighter clinical symptoms and deep icterus irrelevancy Its feature of behavior.

5. posthepatitic cirrhosis

Early-phase hepatocirrhosis must rely on pathological diagnosis, ultrasonic and CT examination etc., and celioscopy most has reference value.Clinical diagnosis Cirrhosis, refers to that chronic hepatitis patient has portal hypertension to show, and such as stomach wall and varices of esophagus, seroperitoneum, liver reduce, spleen Greatly, portal vein, Dsv are broadening, and eliminating other reasons can cause portal hypertension person, is divided into work according to hepatitis active level Dynamic property and inactive liver cirrhosis.

Check

1. Liver function grade

(1) serum enzyme detection ALT (ALT) concentration in liver cell is higher 104 times than serum, as long as having 1% necrosis of liver cells can make serum-concentration raise 1 times, and oxyhepatitis positive rate reaches 80%～100%.AST (AST) in cardiac muscle, concentration is the highest, thus judge on liver function when affecting, first should get rid of the impact of heart disease.AST 80% in liver cell mitochondria, and generally, hepatic injury rises a height of master with ALT, if serum AST substantially increases, often represents liver Cell severe necrosis.In mitochondria, AST is released into blood, and the degree that serum transaminase increases is substantially equal with lesion severity OK, but during serious hepatitis, may occur in which that bilirubin constantly increases, and transaminase declines on the contrary, i.e. courage enzyme separates, and prompting liver cell is bad Dead serious.

(2) haemocyanin detection the most often using haemocyanin as the biochemical indicator of liver protein metabolism, chronic hepatitis During cirrhosis, often having seralbumin to decline, globulin levels raises, and rises a height of master with gamma globulin.

(3) serum bilirubin detection liver has picked-up transhipment in bilirubin metabolism, and in conjunction with the function of excretion, liver function is damaged Wound causes bilirubin level and raises, and in addition to cholestatic hepatitis, bilirubin level is directly proportional to the hepatic injury order of severity.

(4) prothrombin time (PT) can synthesize factor II, the situation of VII, Ⅸ, Ⅹ, hepatopathy by sensitivity response liver Time PT length be proportionate with hepatic injury degree.

2. mark of hepatitis virus detection

(1) hepatitis A oxyhepatitis patient, the anti-HAVIg of serum is that the unit M positive can be diagnosed as HAV recent infection, anti- HAV-Ig be unit g be unit positive prompting previous infection and existing immunity.

(2) hepatitis B 1. HBsAg be unit and Anti-HBs antibody: HBsAg be the unit positive show HBV be currently in infection rank Section, Anti-HBs antibody is that the immunoprotective antibody positive is shown and produced the immunity to HBV.Chronic HBsAg is examining of unit carrier Disconnected according to be that without any clinical symptoms and sign, liver function normally HBsAg is more than 6 months persons of unit lasting masculin.② HBeAg be unit with anti-HBe:HBeAg be the unit positive be that HBV enlivens duplication and the strong index of infectiousness, tested serum from HBeAg be unit positive shift be the anti-HBe positive represent disease have alleviation infectivity weaken.3. HBcAg is that unit is with anti- HBc:HBcAg is that the prompting of the unit positive exists complete HBV particle and directly reacts, and HBV is active to be replicated owing to detection method is complicated Clinical few use.Anti-HBc is the mark of HBV infection, and anti-HBc Ig is that the prompting of the unit M positive is in infection in early days, internal ill Poison replicates.Chronic mild hepatitis B and HBsAg be in unit carrier HBsAg be unit, HBeAg be unit and anti-HBc Three equal positives have hyperinfection index and are difficult to cloudy turning.

Mark of molecular biology: with molecule hybridization or the detection of PCR method, serum HBV DNA is positive, and directly reaction HBV lives The duplication that jumps has infectiousness.

(3) hepatitis C due in blood amount of antigen cannot measure very little, therefore can only detect antibody anti-HCV be HCV infection mark, It it not protection antibody.Detecting by shell type reverse transcription PCR method, the serum HCV-RNA positive shows that virus is enlivened duplication and had infectiousness.

(4) hepatitis D HDV is defective virus, and relying on HBsAg is unit just reproducible, can behave as HDV-HBV simultaneously Infect, HDAg is that unit only occurs a couple of days in blood, occur therewith Ig be the anti-HD of unit M type, chronic HDV infection anti-HD Ig Be that unit persistently raises for unit g, detect in serum HDV-RNA be then more directly, more special diagnostic method.

(5) Hepatitis E oxyhepatitis patient, detecting anti-HEVIg in serum is unit M antibody, Ig in convalescent serum Be that unit antibody titer is the lowest for unit g, anti-HEV Ig be unit g be to be shorter than 1 year unit duration in serum, therefore anti- HEV Ig be unit M, anti-HEV Ig be unit g be that unit all can be as HEV recent infection index.

(6) hepatitis G RT-PCR technology can detect Hg is unit V RNA, is that Hg is the early diagnosis of unit V and monitors disease Toxemic effective ways, anti-Hg be the Ig of unit V be unit M and Ig be unit g be that unit antibody is the most ripe, deposit Low in recall rate and with the feature such as RT-PCR result does not corresponds.

3. liver wears biopsy

It is the leading indicator of diagnosis Various Types of Hepatitis, is also the conclusive evidence of diagnosis early-phase hepatocirrhosis, but because is wound Property inspection still can not be popularized also not as first-selection.

The most ultrasonic and CT scan (CT)

Ultrasonic examination apply widely, chronic hepatitis, the diagnosis index of hepatitis cirrhosis, clearly and can help cirrhosis and Liver cancer and the discriminating of jaundice.CT examination also has important value to above-mentioned diagnosis.

Summary of the invention

It is an object of the invention to design a kind of medicine treating virus hepatitis and preparation method thereof that can be used for, described Medicine has steady quality, uses safety, taking convenience, and curative effect is fast, and cure rate is high, and recurrence rate is low, has clearing heat and promoting diuresis, soothing the liver Reason spleen, the function of blood stasis-eliminating and stagnation-dissipating, and take, according to difference, the compatibility that period employing is different, it is possible to make curative effect of medication perform to pole Excellent depth, is a kind of medicine to virus hepatitis with significant curative effect；The present invention can be different according to media for preparing Time of Administration section and use the viral hepatitis treatment medicine of different compatibility and specifically developed preparation method, by different periods Medication is prepared respectively, and user can be made in each administration time section by optimized for drug effect absorption.

The present invention is achieved through the following technical solutions: a kind of medicine that can be used for treating virus hepatitis, described medicine Compatibility is by myrobalan, terminaliae billericae,fructus, Aconitum pulchellum Hand.-Mazz, aconitum tanguticumStapf, Tangut aconite, Herba Dracocephali Tangutici, horse bezoar, natural ox gallstone, bear gall, white Santal, santal, agalloch eaglewood, Moschus, iron powder, silver grey, copper is grey, vermiculite, Tabasheer, turquoise, red coral, pearl, lapis lazuli, silver Zhu, nitre, crab, Phytolacca acinosa, match north corydalis, slag tame and docile cream, corydalis tuber, emblic, safflower, safflower, seed of pomegranate, cloves, black Borneol, tsaoko, Indian Herba Swertiae bimaculatae, radix jurineae, Semen Herpetospermi, mango core, seed of Cortex Holarrhenae Antidysentericae, the Bi roots of grass, coriander, the root of kudzu vine, cassia seed, tooth Leaf iron son, myrrh, Radix Gentianae Macrophyllae, green suede wormwood artemisia, Hong Lian, German tamarisk, birthwort, cape jasmine and sugar composition.

Further the most described medicine, uses following set-up mode: described medicine is for joining especially 5 is size-reduced, sieves, facing-up, mixing, and filling or pill, polishing, envelope are moulded, quality examination, the technique of finished product warehouse-in are prepared from.

Further the most described medicine, uses following set-up mode: described compatibility is by every especially It medicine time section difference be formulated as Part I, Part II, Part III and Part IV, and every part in contained Medicinal material is that unit proportioning is prepared by following weight g:

Part I

Myrobalan 58.00 Aconitum pulchellum Hand.-Mazz 20.00

Iron powder 58.00 Phytolacca acinosa 20.00

Moschus 1.45 slag tames and dociles cream 20.00

Vermiculite 18.00 corydalis tuber 19.00

Crab 18.00 terminaliae billericae,fructus 20.00

Emblic 20.00 matches north corydalis 18.00

Tabasheer 17.15 turquoise 12.20

Safflower 17.00 red coral 12.25

Cloves 17.55 lapis lazuli 12.25

Tsaoko 17.50 Indian Herba Swertiae bimaculatae 12.50

Radix jurineae 16.5 Semen Herpetospermi 13.00

Mango core 21.00 seed of Cortex Holarrhenae Antidysentericae 12.75

The Santalum album 21.00 Bi roots of grass 11.00

Santal 18.50 coriander 11.50

Agalloch eaglewood 20.50 cassia seed 10.20

Vermilion 18.05 tingia sub-iron son 7.55

Tangut aconite 19.50 myrrh 7.00

Radix Gentianae Macrophyllae 12.00 horse bezoar 6.75

Natural ox gallstone 8.00 bear gall 8.50

Pearl 12.75 root of kudzu vine 20.00

Cape jasmine 21.50

Part II

Safflower 11.00 Indian Herba Swertiae bimaculatae 80.00

Safflower 74.00 Radix Gentianae Macrophyllae 82.00

Match north corydalis 72.50 Semen Herpetospermi 52.00

Bear gall 6.50 Tabasheer 72.50

Green suede wormwood artemisia 75.45 dried feces of Sus scrofa L 51.25

Nitre 31.25 slag tames and dociles cream 75.45

Silver grey 3.20 radix jurineaes 74.10

Aconitum tanguticumStapf 75.50 seed of pomegranate 15.00

Part III

Indian Herba Swertiae bimaculatae 78.00 safflower 11.11

Safflower 42.25 aconitum tanguticumStapf 58.75

Myrobalan 48.40 Radix Gentianae Macrophyllae 50.00

Terminaliae billericae,fructus 52.00 matches north corydalis 41.20

Emblic 52.25 Herba Dracocephali Tangutici 55.55

Flood even 41.20 slags tame and docile cream 42.10

Seed of pomegranate 38.70 coriander 44.20

German tamarisk 40.20 bronze medal ash 13.50

Turquoise 18.80 seed of Cortex Holarrhenae Antidysentericae 42.50

Green suede wormwood artemisia 44.40 Semen Herpetospermi 61.25

Cape jasmine 30.00

Part IV

Natural ox gallstone 12.00 radix jurineae 75.00

Safflower 70.00 birthwort 101.10

Safflower 14.50 matches north corydalis 102.50

Green suede wormwood artemisia 96.50 Semen Herpetospermi 8.70

Indian Herba Swertiae bimaculatae 78.00 sugar 45.9

Slag tames and dociles cream 101.11 bear gall 7.20.

Further the most described medicine, the especially following set-up mode of employing: described myrobalan and Mao Myrobalan has been myrobalan and the terminaliae billericae,fructus of core, and described crab is the river crab that lives.

A kind of process for preparing medicine that can be used for treating virus hepatitis, the compatibility of described medicine is by section medicine time every day Difference be formulated as Part I, Part II, Part III and Part IV, and in every part contained medicinal material by following heavy Amount g is that unit proportioning is prepared:

Part I

Myrobalan 58.00 Aconitum pulchellum Hand.-Mazz 20.00

Iron powder 58.00 Phytolacca acinosa 20.00

Moschus 1.45 slag tames and dociles cream 20.00

Vermiculite 18.00 corydalis tuber 19.00

Crab 18.00 terminaliae billericae,fructus 20.00

Emblic 20.00 matches north corydalis 18.00

Tabasheer 17.15 turquoise 12.20

Safflower 17.00 red coral 12.25

Cloves 17.55 lapis lazuli 12.25

Tsaoko 17.50 Indian Herba Swertiae bimaculatae 12.50

Radix jurineae 16.5 Semen Herpetospermi 13.00

Mango core 21.00 seed of Cortex Holarrhenae Antidysentericae 12.75

The Santalum album 21.00 Bi roots of grass 11.00

Santal 18.50 coriander 11.50

Agalloch eaglewood 20.50 cassia seed 10.20

Vermilion 18.05 tingia sub-iron son 7.55

Tangut aconite 19.50 myrrh 7.00

Radix Gentianae Macrophyllae 12.00 horse bezoar 6.75

Natural ox gallstone 8.00 bear gall 8.50

Pearl 12.75 root of kudzu vine 20.00

Cape jasmine 21.50

Part II

Safflower 11.00 Indian Herba Swertiae bimaculatae 80.00

Safflower 74.00 Radix Gentianae Macrophyllae 82.00

Match north corydalis 72.50 Semen Herpetospermi 52.00

Bear gall 6.50 Tabasheer 72.50

Green suede wormwood artemisia 75.45 dried feces of Sus scrofa L 51.25

Nitre 31.25 slag tames and dociles cream 75.45

Silver grey 3.20 radix jurineaes 74.10

Aconitum tanguticumStapf 75.50 seed of pomegranate 15.00

Part III

Indian Herba Swertiae bimaculatae 78.00 safflower 11.11

Safflower 42.25 aconitum tanguticumStapf 58.75

Myrobalan 48.40 Radix Gentianae Macrophyllae 50.00

Terminaliae billericae,fructus 52.00 matches north corydalis 41.20

Emblic 52.25 Herba Dracocephali Tangutici 55.55

Flood even 41.20 slags tame and docile cream 42.10

Seed of pomegranate 38.70 coriander 44.20

German tamarisk 40.20 bronze medal ash 13.50

Turquoise 18.80 seed of Cortex Holarrhenae Antidysentericae 42.50

Green suede wormwood artemisia 44.40 Semen Herpetospermi 61.25

Cape jasmine 30.00

Part IV

Natural ox gallstone 12.00 radix jurineae 75.00

Safflower 70.00 birthwort 101.10

Safflower 14.50 matches north corydalis 102.50

Green suede wormwood artemisia 96.50 Semen Herpetospermi 8.70

Indian Herba Swertiae bimaculatae 78.00 sugar 45.9

Slag tames and dociles cream 101.11 bear gall 7.20；

Described preparation method includes:

1) respectively by the medicinal material of Part I, Part II, Part III and Part IV by regulation Processing methods；

2) expensive thin medicinal material natural ox gallstone, bear gall, Moschus, safflower are developed respectively, sieve for subsequent use；

3) remaining pulverizing medicinal materials in addition to cow-bezoar, bear gall, Moschus, safflower becomes fine powder, sieves；

4) cow-bezoar, bear gall, Moschus, safflower fine powder facing-up are added, mixing；

5) filling capsule, every 0.3g is unit；Or parcel sugar-coat make pill；

6) mould through polishing, envelope again, quality examination, finished product warehouse-in, obtain brown powder, the micro-perfume (or spice) of gas, the encapsulated pharmaceuticals of bitter or Wrap up in outward the pill medicine of sugar-coat.

The present invention compared with prior art, has the following advantages and beneficial effect:

Medicine of the present invention has steady quality, uses safety, taking convenience, and curative effect is fast, and cure rate is high, and recurrence rate is low, tool There are clearing heat and promoting diuresis, soothing the liver reason spleen, the function of blood stasis-eliminating and stagnation-dissipating, and take, according to difference, the compatibility that period employing is different, it is possible to make Curative effect of medication performs to the most excellent depth, is a kind of medicine to virus hepatitis with significant curative effect；The present invention is for preparing The viral hepatitis treatment medicine of different compatibility can be used and specifically developed preparation according to media difference Time of Administration section Method, prepares respectively by the medication of different periods, and user can be made in each administration time section, drug effect is optimum The absorption changed.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.

Embodiment 1:

A kind of medicine that can be used for treating virus hepatitis, the compatibility of described medicine is by myrobalan, terminaliae billericae,fructus, Aconitum pulchellum Hand.-Mazz, Gan Qing The rhizome of Chinese monkshood, Tangut aconite, Herba Dracocephali Tangutici, horse bezoar, natural ox gallstone, bear gall, Santalum album, santal, agalloch eaglewood, Moschus, iron powder, silver Ash, copper ash, vermiculite, Tabasheer, turquoise, red coral, pearl, lapis lazuli, vermilion, nitre, crab, Phytolacca acinosa, match north corydalis, slag Tame and docile cream, corydalis tuber, emblic, safflower, safflower, seed of pomegranate, cloves, dried feces of Sus scrofa L, tsaoko, Indian Herba Swertiae bimaculatae, radix jurineae, ripple Rib melon seeds, mango core, seed of Cortex Holarrhenae Antidysentericae, the Bi roots of grass, coriander, the root of kudzu vine, cassia seed, tingia sub-iron son, myrrh, Radix Gentianae Macrophyllae, green suede wormwood artemisia, Hong Lian, German tamarisk, birthwort, cape jasmine and sugar composition.

Embodiment 2:

The present embodiment is to optimize further on the basis of above-described embodiment, the most described medicine Thing, uses especially following set-up mode: described medicine is that compatibility is size-reduced, sieves, facing-up, mixing, filling or pill, polishing, Envelope mould, quality examination, finished product warehouse-in technique be prepared from.

Embodiment 3:

The present embodiment is to optimize further on the basis of any of the above-described embodiment, institute the most to better implement the present invention State medicine, use especially following set-up mode: described compatibility by the difference of section medicine time every day be formulated as Part I, second Partly, in Part III and Part IV, and every part, contained medicinal material is that unit proportioning is prepared by following weight g:

Part I

Myrobalan 58.00 Aconitum pulchellum Hand.-Mazz 20.00

Iron powder 58.00 Phytolacca acinosa 20.00

Moschus 1.45 slag tames and dociles cream 20.00

Vermiculite 18.00 corydalis tuber 19.00

Crab 18.00 terminaliae billericae,fructus 20.00

Emblic 20.00 matches north corydalis 18.00

Tabasheer 17.15 turquoise 12.20

Safflower 17.00 red coral 12.25

Cloves 17.55 lapis lazuli 12.25

Tsaoko 17.50 Indian Herba Swertiae bimaculatae 12.50

Radix jurineae 16.5 Semen Herpetospermi 13.00

Mango core 21.00 seed of Cortex Holarrhenae Antidysentericae 12.75

The Santalum album 21.00 Bi roots of grass 11.00

Santal 18.50 coriander 11.50

Agalloch eaglewood 20.50 cassia seed 10.20

Vermilion 18.05 tingia sub-iron son 7.55

Tangut aconite 19.50 myrrh 7.00

Radix Gentianae Macrophyllae 12.00 horse bezoar 6.75

Natural ox gallstone 8.00 bear gall 8.50

Pearl 12.75 root of kudzu vine 20.00

Cape jasmine 21.50

Part II

Safflower 11.00 Indian Herba Swertiae bimaculatae 80.00

Safflower 74.00 Radix Gentianae Macrophyllae 82.00

Match north corydalis 72.50 Semen Herpetospermi 52.00

Bear gall 6.50 Tabasheer 72.50

Green suede wormwood artemisia 75.45 dried feces of Sus scrofa L 51.25

Nitre 31.25 slag tames and dociles cream 75.45

Silver grey 3.20 radix jurineaes 74.10

Aconitum tanguticumStapf 75.50 seed of pomegranate 15.00

Part III

Indian Herba Swertiae bimaculatae 78.00 safflower 11.11

Safflower 42.25 aconitum tanguticumStapf 58.75

Myrobalan 48.40 Radix Gentianae Macrophyllae 50.00

Terminaliae billericae,fructus 52.00 matches north corydalis 41.20

Emblic 52.25 Herba Dracocephali Tangutici 55.55

Flood even 41.20 slags tame and docile cream 42.10

Seed of pomegranate 38.70 coriander 44.20

German tamarisk 40.20 bronze medal ash 13.50

Turquoise 18.80 seed of Cortex Holarrhenae Antidysentericae 42.50

Green suede wormwood artemisia 44.40 Semen Herpetospermi 61.25

Cape jasmine 30.00

Part IV

Natural ox gallstone 12.00 radix jurineae 75.00

Safflower 70.00 birthwort 101.10

Safflower 14.50 matches north corydalis 102.50

Green suede wormwood artemisia 96.50 Semen Herpetospermi 8.70

Indian Herba Swertiae bimaculatae 78.00 sugar 45.9

Slag tames and dociles cream 101.11 bear gall 7.20.

Embodiment 4:

The present embodiment is to optimize further on the basis of any of the above-described embodiment, institute the most to better implement the present invention State medicine, use following set-up mode especially: described myrobalan and terminaliae billericae,fructus have been myrobalan and the terminaliae billericae,fructus of core, described crab For the river crab that lives.

Embodiment 5:

A kind of process for preparing medicine that can be used for treating virus hepatitis, the compatibility of described medicine is by section medicine time every day not With being formulated as Part I, Part II, Part III and Part IV, and medicinal material contained by every part is by following weight g Prepare for unit proportioning:

Part I

Myrobalan 58.00 Aconitum pulchellum Hand.-Mazz 20.00

Iron powder 58.00 Phytolacca acinosa 20.00

Moschus 1.45 slag tames and dociles cream 20.00

Vermiculite 18.00 corydalis tuber 19.00

Crab 18.00 terminaliae billericae,fructus 20.00

Emblic 20.00 matches north corydalis 18.00

Tabasheer 17.15 turquoise 12.20

Safflower 17.00 red coral 12.25

Cloves 17.55 lapis lazuli 12.25

Tsaoko 17.50 Indian Herba Swertiae bimaculatae 12.50

Radix jurineae 16.5 Semen Herpetospermi 13.00

Mango core 21.00 seed of Cortex Holarrhenae Antidysentericae 12.75

The Santalum album 21.00 Bi roots of grass 11.00

Santal 18.50 coriander 11.50

Agalloch eaglewood 20.50 cassia seed 10.20

Vermilion 18.05 tingia sub-iron son 7.55

Tangut aconite 19.50 myrrh 7.00

Radix Gentianae Macrophyllae 12.00 horse bezoar 6.75

Natural ox gallstone 8.00 bear gall 8.50

Pearl 12.75 root of kudzu vine 20.00

Cape jasmine 21.50

Part II

Safflower 11.00 Indian Herba Swertiae bimaculatae 80.00

Safflower 74.00 Radix Gentianae Macrophyllae 82.00

Match north corydalis 72.50 Semen Herpetospermi 52.00

Bear gall 6.50 Tabasheer 72.50

Green suede wormwood artemisia 75.45 dried feces of Sus scrofa L 51.25

Nitre 31.25 slag tames and dociles cream 75.45

Silver grey 3.20 radix jurineaes 74.10

Aconitum tanguticumStapf 75.50 seed of pomegranate 15.00

Part III

Indian Herba Swertiae bimaculatae 78.00 safflower 11.11

Safflower 42.25 aconitum tanguticumStapf 58.75

Myrobalan 48.40 Radix Gentianae Macrophyllae 50.00

Terminaliae billericae,fructus 52.00 matches north corydalis 41.20

Emblic 52.25 Herba Dracocephali Tangutici 55.55

Flood even 41.20 slags tame and docile cream 42.10

Seed of pomegranate 38.70 coriander 44.20

German tamarisk 40.20 bronze medal ash 13.50

Turquoise 18.80 seed of Cortex Holarrhenae Antidysentericae 42.50

Green suede wormwood artemisia 44.40 Semen Herpetospermi 61.25

Cape jasmine 30.00

Part IV

Natural ox gallstone 12.00 radix jurineae 75.00

Safflower 70.00 birthwort 101.10

Safflower 14.50 matches north corydalis 102.50

Green suede wormwood artemisia 96.50 Semen Herpetospermi 8.70

Indian Herba Swertiae bimaculatae 78.00 sugar 45.9

Slag tames and dociles cream 101.11 bear gall 7.20；

Described preparation method includes:

5) filling capsule, every 0.3g is unit；Or parcel sugar-coat make pill；

The above, be only presently preferred embodiments of the present invention, and the present invention not does any pro forma restriction, every depends on Any simple modification of being made above example according to the technical spirit of the present invention, equivalent variations, each fall within the protection of the present invention Within the scope of.

Claims

1. one kind can be used for treat virus hepatitis medicine, it is characterised in that: the compatibility of described medicine by myrobalan, terminaliae billericae,fructus, Aconitum pulchellum Hand.-Mazz, aconitum tanguticumStapf, Tangut aconite, Herba Dracocephali Tangutici, horse bezoar, natural ox gallstone, bear gall, Santalum album, santal, agalloch eaglewood, Moschus, iron powder, silver grey, copper is grey, vermiculite, Tabasheer, turquoise, red coral, pearl, lapis lazuli, vermilion, nitre, crab, business Land, match north corydalis, slag tame and docile cream, corydalis tuber, emblic, safflower, safflower, seed of pomegranate, cloves, dried feces of Sus scrofa L, tsaoko, India river deer Tooth dish, radix jurineae, Semen Herpetospermi, mango core, seed of Cortex Holarrhenae Antidysentericae, the Bi roots of grass, coriander, the root of kudzu vine, cassia seed, tingia sub-iron son, myrrh, white Flower bark of ash, green suede wormwood artemisia, Hong Lian, German tamarisk, birthwort, cape jasmine and sugar composition.

A kind of medicine that can be used for treating virus hepatitis the most according to claim 1, it is characterised in that: described medicine Size-reduced for compatibility, to sieve, facing-up, mixing, filling or pill, polishing, envelope are moulded, prepared by quality examination, the technique of finished product warehouse-in Form.

A kind of medicine that can be used for treating virus hepatitis the most according to claim 1 and 2, it is characterised in that join described in: 5 are formulated as Part I, Part II, Part III and Part IV, and an often part by the difference of section medicine time every day Medicinal material contained by is that unit proportioning is prepared by following weight g:

Part I

Myrobalan 58.00 Aconitum pulchellum Hand.-Mazz 20.00

Iron powder 58.00 Phytolacca acinosa 20.00

Moschus 1.45 slag tames and dociles cream 20.00

Vermiculite 18.00 corydalis tuber 19.00

Crab 18.00 terminaliae billericae,fructus 20.00

Emblic 20.00 matches north corydalis 18.00

Tabasheer 17.15 turquoise 12.20

Safflower 17.00 red coral 12.25

Cloves 17.55 lapis lazuli 12.25

Tsaoko 17.50 Indian Herba Swertiae bimaculatae 12.50

Radix jurineae 16.5 Semen Herpetospermi 13.00

Mango core 21.00 seed of Cortex Holarrhenae Antidysentericae 12.75

The Santalum album 21.00 Bi roots of grass 11.00

Santal 18.50 coriander 11.50

Agalloch eaglewood 20.50 cassia seed 10.20

Vermilion 18.05 tingia sub-iron son 7.55

Tangut aconite 19.50 myrrh 7.00

Radix Gentianae Macrophyllae 12.00 horse bezoar 6.75

Natural ox gallstone 8.00 bear gall 8.50

Pearl 12.75 root of kudzu vine 20.00

Cape jasmine 21.50

Part II

Safflower 11.00 Indian Herba Swertiae bimaculatae 80.00

Safflower 74.00 Radix Gentianae Macrophyllae 82.00

Match north corydalis 72.50 Semen Herpetospermi 52.00

Bear gall 6.50 Tabasheer 72.50

Green suede wormwood artemisia 75.45 dried feces of Sus scrofa L 51.25

Nitre 31.25 slag tames and dociles cream 75.45

Silver grey 3.20 radix jurineaes 74.10

Aconitum tanguticumStapf 75.50 seed of pomegranate 15.00

Part III

Indian Herba Swertiae bimaculatae 78.00 safflower 11.11

Safflower 42.25 aconitum tanguticumStapf 58.75

Myrobalan 48.40 Radix Gentianae Macrophyllae 50.00

Terminaliae billericae,fructus 52.00 matches north corydalis 41.20

Emblic 52.25 Herba Dracocephali Tangutici 55.55

Flood even 41.20 slags tame and docile cream 42.10

Seed of pomegranate 38.70 coriander 44.20

German tamarisk 40.20 bronze medal ash 13.50

Turquoise 18.80 seed of Cortex Holarrhenae Antidysentericae 42.50

Green suede wormwood artemisia 44.40 Semen Herpetospermi 61.25

Cape jasmine 30.00

Part IV

Natural ox gallstone 12.00 radix jurineae 75.00

Safflower 70.00 birthwort 101.10

Safflower 14.50 matches north corydalis 102.50

Green suede wormwood artemisia 96.50 Semen Herpetospermi 8.70

Indian Herba Swertiae bimaculatae 78.00 sugar 45.9

Slag tames and dociles cream 101.11 bear gall 7.20.

The most according to claim 3 a kind of can be used for treat virus hepatitis medicine, it is characterised in that: described myrobalan and Terminaliae billericae,fructus has been myrobalan and the terminaliae billericae,fructus of core, and described crab is the river crab that lives.

A kind of medicine that can be used for treating virus hepatitis the most according to claim 1 and 2, it is characterised in that scold described in: Son and terminaliae billericae,fructus have been myrobalan and the terminaliae billericae,fructus of core, and described crab is the river crab that lives.

6. a kind of preparation method that can be used for treating the medicine of virus hepatitis as described in any one of claim 1-5, it is special Levy and be: the compatibility of described medicine by the difference of section medicine time every day be formulated as Part I, Part II, Part III and In Part IV, and every part, contained medicinal material is that unit proportioning is prepared by following weight g:

Part I

Myrobalan 58.00 Aconitum pulchellum Hand.-Mazz 20.00

Iron powder 58.00 Phytolacca acinosa 20.00

Moschus 1.45 slag tames and dociles cream 20.00

Vermiculite 18.00 corydalis tuber 19.00

Crab 18.00 terminaliae billericae,fructus 20.00

Emblic 20.00 matches north corydalis 18.00

Tabasheer 17.15 turquoise 12.20

Safflower 17.00 red coral 12.25

Cloves 17.55 lapis lazuli 12.25

Tsaoko 17.50 Indian Herba Swertiae bimaculatae 12.50

Radix jurineae 16.5 Semen Herpetospermi 13.00

Mango core 21.00 seed of Cortex Holarrhenae Antidysentericae 12.75

The Santalum album 21.00 Bi roots of grass 11.00

Santal 18.50 coriander 11.50

Agalloch eaglewood 20.50 cassia seed 10.20

Vermilion 18.05 tingia sub-iron son 7.55

Tangut aconite 19.50 myrrh 7.00

Radix Gentianae Macrophyllae 12.00 horse bezoar 6.75

Natural ox gallstone 8.00 bear gall 8.50

Pearl 12.75 root of kudzu vine 20.00

Cape jasmine 21.50

Part II

Safflower 11.00 Indian Herba Swertiae bimaculatae 80.00

Safflower 74.00 Radix Gentianae Macrophyllae 82.00

Match north corydalis 72.50 Semen Herpetospermi 52.00

Bear gall 6.50 Tabasheer 72.50

Green suede wormwood artemisia 75.45 dried feces of Sus scrofa L 51.25

Nitre 31.25 slag tames and dociles cream 75.45

Silver grey 3.20 radix jurineaes 74.10

Aconitum tanguticumStapf 75.50 seed of pomegranate 15.00

Part III

Indian Herba Swertiae bimaculatae 78.00 safflower 11.11

Safflower 42.25 aconitum tanguticumStapf 58.75

Myrobalan 48.40 Radix Gentianae Macrophyllae 50.00

Terminaliae billericae,fructus 52.00 matches north corydalis 41.20

Emblic 52.25 Herba Dracocephali Tangutici 55.55

Flood even 41.20 slags tame and docile cream 42.10

Seed of pomegranate 38.70 coriander 44.20

German tamarisk 40.20 bronze medal ash 13.50

Turquoise 18.80 seed of Cortex Holarrhenae Antidysentericae 42.50

Green suede wormwood artemisia 44.40 Semen Herpetospermi 61.25

Cape jasmine 30.00

Part IV

Natural ox gallstone 12.00 radix jurineae 75.00

Safflower 70.00 birthwort 101.10

Safflower 14.50 matches north corydalis 102.50

Green suede wormwood artemisia 96.50 Semen Herpetospermi 8.70

Indian Herba Swertiae bimaculatae 78.00 sugar 45.9

Slag tames and dociles cream 101.11 bear gall 7.20；

Described preparation method includes:

5) filling capsule, every 0.3g is unit；Or parcel sugar-coat make pill；