CN105853659A - Traditional Chinese medicine composition for treating polycystic ovarian syndrome - Google Patents
Traditional Chinese medicine composition for treating polycystic ovarian syndrome Download PDFInfo
- Publication number
- CN105853659A CN105853659A CN201610431771.5A CN201610431771A CN105853659A CN 105853659 A CN105853659 A CN 105853659A CN 201610431771 A CN201610431771 A CN 201610431771A CN 105853659 A CN105853659 A CN 105853659A
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- fructus
- polycystic ovarian
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating a polycystic ovarian syndrome. Roasted herba epimedii and rhizoma acori graminei serve as monarch drugs, kidney tonifying and phlegm reducing are regarded as equally important, and elimination and supplementary are simultaneously implemented. Amethysts, cornu cervi degelatinatum, semen cuscutae, rhizoma pinelliae and fructus aurantii immaturus serve as ministerial drugs, amethysts, cornu cervi degelatinatum and semen cuscutae complement one another to achieve mutual promotion with roasted herba epimedii for use, and therefore the effect of tonifying the kidney to strengthen yang of roasted herba epimedii is improved; rhizoma pinelliae and fructus aurantii immaturus complement each other to achieve mutual promotion with rhizoma acori graminei for use, and therefore the effects of reducing phlegm and removing dampness of rhizoma acori graminei are enhanced. Fructus trichosanthis, bile arisaema, rhizoma atractylodis, prepared rhizoma cyperi, radix salvia miltiorrhiza and fructus leonuri jointly serve as adjuvant drugs, fructus trichosanthis, bile arisaema and rhizoma atractylodis have the effects of clearing heat and reducing phlegm, and prepared rhizoma cyperi, radix salvia miltiorrhiza and fructus leonuri have the effect of promoting blood circulation for regulating menstruation. Licorice roots are used for moderating the property of all the herbs and serve as a guide drug. All the drugs jointly achieve the effects of tonifying the kidney, reducing the phlegm and promoting blood circulation to promote menstruation. The traditional Chinese medicine composition for treating the polycystic ovarian syndrome is exact in treatment effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition treating polycystic ovarian syndrome, belong to traditional Chinese medicine field.
Background technology
In polycystic ovarian syndrome (polycystic ovary syndrome, PCOS) is a kind of common women
Dyssecretosis disease, the syndrome being characterized with hyperandrogenism, ovulation failure and polycystic ovary.Cause
This patient's menstruation irregularis, infertile, fat, hirsutism etc. perplex and occur diabetes, cardiovascular disease in the recent period
And the risk of the multiple long term complication such as carcinoma of endometrium, it has also become affect women physically and mentally healthy and quality of life
One of most common and most important disease.
In recent years, the clinical prevalence of this disease is in rising trend, primary disease typically in all women patient be about
1%-4%；In Women of Childbearing Age, prevalence is 6%-8%.In PCOS patient, incidence of infertility there are about 35%-95%.
Early, sickness rate is high, with hyperandrogenism, chronic anovulation and ovary polycystic change etc. for this disease age of onset
Some row show as diagnostic criteria.After women of child-bearing age's ovulation treatment, pregnancy rate is low, there is no effective treatment at present
Method, has a strong impact on WomanHealth.
The Therapeutic Method of PCOS is mainly had by modern medicine: western medicine, operative treatment, Chinese traditional treatment etc..
Western medicine has certain dependency, and after drug withdrawal, symptom is the most repeatedly, and operation has the risk etc. that attachment area adhesion occurs.And
Chinese medicine can integrally-regulated organism endocrine function, few side effects.
There is the report of the Chinese medicine for treating polycystic ovarian syndrome of being correlated with at present, such as CN201510022570.5
Treatment polycystic ovarian syndrome Chinese medicine composition, be made up of following material medicine: Radix Rehmanniae Preparata 22-26g,
Herba Epimedii 13-17g, Semen Cuscutae 27-33g, Rhizoma Atractylodis Macrocephalae 13-17g, Poria 13-17g, Pericarpium Citri Reticulatae 8-12g, Rhizoma Zingiberis Recens half
Summer 7-11g, Rhizoma Cyperi 5-7g, Radix Cyathulae 13-17g, Radix Salviae Miltiorrhizae 27-33g and Semen Sinapis Albae 8-12g, have the kidney warming
Spleen invigorating, dissipating phlegm and removing blood stasis, the merit of regulating menstruation and assisting pregnancy, be effective to treat polycystic ovarian syndrome, good effect, medication
Safety, has no side effect, and stable curative effect is safe and reliable.CN201510385406.0 discloses a kind for the treatment of
The Chinese medicine composition of polycystic ovarian syndrome, is made up of the material medicine of following parts by weight meter: Radix Cudraniae 12-
25 parts, Fructus Crataegi 10-40 part, Radix Salviae Miltiorrhizae 10-25 part, Calyx seu Fructus physalis 5-15 part, Semen Coicis 10-30 part, Pericarpium Citri Reticulatae
6-15 part, Arisaema Cum Bile 5-10 part, Semen Cuscutae 10-30 part and Herba Epimedii 5-15 part, be effective to treatment many
Capsule Ovary Syndrome.But still do not have pertinent literature to report that the present invention treated in polycystic ovarian syndrome at present
Drug composition.
Summary of the invention
It is an object of the invention to the deficiency overcome in traditional treatment, it is provided that a kind of polycystic ovarian syndrome for the treatment of
Chinese medicine composition.
Technical solution of the present invention is as follows: a kind of Chinese medicine composition treating polycystic ovarian syndrome, in parts by weight,
Crude drug including following component: Fluoritum 20-30 part, processs Herba Epimedii 10-15 part, Rhizoma Atractylodis 10-20 part,
Rhizoma Acori Graminei 10-20 part, Fructus Aurantii Immaturus 10-15 part, Rhizoma Pinelliae 6-12 part, Arisaema Cum Bile 5-10 part, Cornu Cervi Degelatinatum 10-20
Part, Fructus Trichosanthis 10-20 part, Fructus Leonuri 10-20 part, Semen Cuscutae 10-20 part, Rhizoma Cyperi (processed) 10-20 part, Radix Salviae Miltiorrhizae
10-20 part, Radix Glycyrrhizae Preparata 5-10 part.
Preferably, a kind of Chinese medicine composition treating polycystic ovarian syndrome of the present invention, in parts by weight, including
The crude drug of following component: Fluoritum 24 parts, processs Herba Epimedii 12 parts, Rhizoma Atractylodis 15 parts, Rhizoma Acori Graminei 15 parts,
Fructus Aurantii Immaturus 12 parts, the Rhizoma Pinelliae 9 parts, Arisaema Cum Bile 6 parts, Cornu Cervi Degelatinatum 15 parts, Fructus Trichosanthis 15 parts, Fructus Leonuri 18 parts,
Semen Cuscutae 15 parts, Rhizoma Cyperi (processed) 15 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Glycyrrhizae Preparata 6 parts.
Preparation method: be decocted in water for oral dose, potion on the one, divides and sooner or later takes for twice.
Chinese medicine composition of the present invention can also be prepared as the dosage forms such as Chinese medicine capsules, granule, tablet, powder.
Therefore, the present invention also provide for the Chinese medicine composition of above-mentioned treatment polycystic ovarian syndrome in preparation prevention and
/ or treatment Obesity-type Polycystic Ovary Syndrome medicine in application.
Traditional Chinese Medicine is thought, menstruation is-kidney-sky decyl-punching appoints-effect of uterus Reproductive Axis, be menses, internal organs dirty,
QI and blood, meridians coordinative role are in the physiological phenomenon of uterus.Fu Qingzhu speech " through this in kidney ", " going out all kidneys through water ".
Illustrate that the material source of menstruation is originally in kidney.POCS patient or because of congenital deficiency of kidney-QI, or because damaging spleen kidney the day after tomorrow,
Normal cause stagnation of phlegm-damp punching is appointed, and stops up stagnant uterus, has upset the physiological action of kidney-sky decyl-punching times-uterus, the moon has occurred
Through dilute, amenorrhea.Phlegm-dampness constitution person has itself can damage kidney yang, the two reciprocal causation.It is considered that POCS
Main pathogenesis characteristics be deficiency in origin and excess in superficiality, deficiency in origin for suffering from a deficiency of the kidney, mark actually stop in blood stasis, stagnation of phlegm-damp, therefore this
Inventor is reduced phlegm with the kidney invigorating, and promoting blood circulation to restore menstrual flow is that the rule for the treatment of has been invented the present invention capsule that disappears and educated heir's soup, Chinese prescription of the present invention
Rationally, Fang Yi is explained as follows:
Monarch drug: process Herba Epimedii, Rhizoma Acori Graminei.Process Herba Epimedii acrid in the mouth, sweet, warm in nature.Return liver, kidney channel.Function is mended
Kidney yang, bone and muscle strengthening, wind-damp dispelling." herbal classic ": " main impotence is hindered absolutely, pains in the penis.Diuresis, physical strength profiting,
Qiang Zhi." " Japan hanako materia medica " " controlling all cold wind consumptive disease, mend waist knee joint, heart tonifying power, husband's sun absolutely does not rises,
The cloudy absolutely loss of fecundity of woman, muscles and bones contraction is anxious, and extremity are not appointed, and the octogenarian of old man's dusk, the middle age is forgetful." " Elementary Medicine ":
" the kidney invigorating is empty, supporing yang.Controlling hemiplegia hands and feet caused by paralysis, limbs skin is meciless." Rhizoma Acori Graminei acrid in the mouth, hardship, warm in nature.
GUIXIN, stomach warp.Function removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Essentials of Matea Medica: " the tonifying liver benefit heart,
Drying by wind, expectorant removing food stagnancy, whet the appetite alleviating distention in middle-JIAO.Treatment is kept silent a mouthful fulminant dysentery, migratory arthralgia infantile convulsion." two medicines share, the kidney invigorating with
Reducing phlegm and lay equal stress on, resolving and invigoration therapies being applied simultaneously, is monarch drug altogether.
Ministerial drug: Fluoritum, Cornu Cervi Degelatinatum, Semen Cuscutae, the Rhizoma Pinelliae, Fructus Aurantii Immaturus.Fluoritum sweet in the mouth, temperature, GUIXIN, lung,
Kidney channel.Function warming the kidney to activate YANG, tranquilizing mind, warming the lung are relievingd asthma.Shennong's Herbal: " main trusted subordinate's cough with dyspnea is evil
Gas, tonifying for the deficiency, woman's wind and cold in uterus, the most pregnant ten years loss of fecundity.Take warming middle-JIAO for a long time, make light of one's life by commiting suicide and prolong life ".Fang Zhongchong
With Fluoritum, to increase the power of its warming the kidney to activate YANG.Cornu Cervi Degelatinatum salty in the mouth, temperature.Return liver, kidney channel.Warming the kidney to activate YANG, receives
Hold back hemostasis.Semen Cuscutae acrid-sweet flavor, property is put down.Enter liver, kidney channel.Invigorating the liver and kidney, benefit marrow, improving eyesight.Fluoritum,
Cornu Cervi Degelatinatum, Semen Cuscutae three medicine are mutually auxiliary with to process Herba Epimedii mutual reinforcement between be use, increase the merit of its reinforcing the kidney and supporting YANG.The Rhizoma Pinelliae is pungent, temperature,
Poisonous, enter spleen, stomach warp.Function drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, " curing mainly secret wanting ": " dry
Stomach is wet, reduces phlegm.Strengthening the spleen gastric qi, dispersing swelling and dissipating binds, removes sputum in the heart." Fructus Aurantii Immaturus, bitter in the mouth, pungent, sour, warm in nature,
Return spleen, stomach, large intestine channel.Function dispelling the stagnated QI removing food stagnancy, the painful abdominal mass that disappears of reducing phlegm." Amplification on Materia Medica addendum ": " Fructus Aurantii Immaturus rushes down expectorant,
Can rush wall and fall wall, sliding key rushes down the medicine of gas also ".The Rhizoma Pinelliae, Fructus Aurantii Immaturus are mutually auxiliary, are use with Rhizoma Acori Graminei mutual reinforcement between, strengthen stone
The power of the eliminating phlegm and removing dampness of Rhizoma Acori Graminei.Therefore, Fluoritum, Cornu Cervi Degelatinatum, Semen Cuscutae, the Rhizoma Pinelliae, Fructus Aurantii Immaturus, be Fang Zhongchen altogether
Medicine.
Adjuvant drug: Fructus Trichosanthis, Arisaema Cum Bile, Rhizoma Atractylodis, Rhizoma Cyperi (processed), Radix Salviae Miltiorrhizae, Fructus Leonuri.Fructus Trichosanthis, property hardship sweet, micro-,
Cold in nature, return lung, stomach, large intestine channel.Function removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, loosening bowel to relieve constipation." product remittance essence is wanted ":
" disappear knot expectorant, dissipates carbuncle poison." " medicine will is planted in Jiangsu ": " harness the river swollen." Arisaema Cum Bile bitter in the mouth is cold, micro-pungent, cool.
Return lung, liver, spleen channel.Function removing heat-phlegm, dispelling wind and relieving convulsion." book on Chinese herbal medicine is just ": " Arisaema Cum Bile, seven system nine persons processed
Fang Jia.Cool in nature than Rhizoma Arisaematis bitter in the mouth, therefore kind solution wind-phlegm heat stagnation." " herbal classic is met former ": " Rhizoma Arisaematis, the Rhizoma Pinelliae are all
Control expectorant medicine also.So Rhizoma Arisaematis specially walks meridians, thus apoplexy, paralysis with as guide；The intestines and stomach specially walked by the Rhizoma Pinelliae, therefore vomiting,
Have loose bowels with as guide." Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel.Function is drying damp and strengthening spleen, dispel
Wind, dissipating cold." pearl sac ": " stomach invigorating can pacify spleen, non-this of all damp-edema can not remove." Li Gao thinks that this medicine " removes
Wet diaphoresis, stomach invigorating peace spleen, control flaccidity key medicine." Rhizoma Cyperi (processed), Radix Salviae Miltiorrhizae, Fructus Leonuri promoting blood flow to regulate menstruation, altogether for side makes
Medicine.
Make medicine: Radix Glycyrrhizae Preparata.Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, with for making.
There is advantages that
(1) to treat polycystic ovarian syndrome evident in efficacy for the present invention, and effective percentage reaches 98.39%, is better than existing
Treatment polycystic ovarian syndrome Chinese medicine.
(2) safety of the present invention, has no side effect, and during clinical treatment, has no adverse reaction, liver after treatment,
Renal function is without exception.
(3) in prescription of the present invention menstrual period, non-menstrual period all can be taken, not affected by menstrual cycle, simple and convenient.
It is especially suitable for making form of Chinese drug, popularization and application.
Below in conjunction with clinical practice, effect of the present invention is described further.
One, clinical data
1 data and method
1.1 physical data
Select in March ,-2016 in January, 2015 in 62 example PCOS patients of the court's reproduction outpatient clinic, year
Age 14～32 years old, average (22.9 ± 2.9) year；The course of disease is the shortest 6 months, the longest 6 years, average (2.9 ± 1.9)
Year.
1.2 case inclusive criterias
1. menoxenia (dilute, amenorrhea or dripping clean, with or without hirsutism, acne, obesity),
Infertile；2. serum testosterone (T) level >=2.2nmol/L；Lutropin (LH)/follicule-stimulating hormone (FSH) (FSH) >=
2.0；3. ultrasound diagnosis bilateral ovaries at least 10 diameter above are the follicle of 2～8mm, and Ovarian Volume increases
Greatly.
1.3 case exclusion standards
1. suffer from the endocrinopathyes such as hyperprolactinemia, thyroid disease, Ke's Cotard, diabetes；②
Nearly 3 months once long-term steroid class medicines；3. hepatic and renal function is abnormal.
1.4 Therapeutic Method
Giving Chinese medicinal formulae of the present invention treatment, every day 1 dose, be decocted in water for oral dose, each menstrual cycle is 1 course for the treatment of, altogether
3 courses for the treatment of.
1.5 statistical method
SPSS11.0 software is used to carry out statistical analysis.
2 results
2.1 treatment standards
Recovery from illness: menstruation rule, 30-35 day a line (later stage follows up a case by regular visits to), menstrual blood volume chromaticness can, painless warp, nothing
Diarrhoea etc., lose weight, abdominal circumference standard, and hair reduces, and acne disappears.Red tongue, white and thin fur, normal pulse.
Endocrine basis is normal, and gynecological's color ultrasound prompting follicular development is normal
Effective: menstruation more rule, 30-45 days a line, menstrual blood volume showed increased, slight dysmenorrhea, under body weight
Fall, abdominal circumference reduces, and acne significantly reduces, red tongue, and tongue is white, stringy pulse.Endocrine basis is normal, woman
Section's color ultrasound points out the follicular development that has superiority
Effective: menstrual cycle improves, and 30-50 days a line (non-hormone medicine effect), menstrual blood volume chromaticness is light
Micromodification is apt to, and dysmenorrhea alleviates, and body weight, abdominal circumference slightly decrease, and acne slightly alleviates, red tongue, white, slippery and moist fur, arteries and veins
Stringy and rapid pulse.Mild symptoms micromodification is apt to, and Endocrine basis display testosterone reduces, and gynecological's color ultrasound points out the follicular development that has superiority.
Invalid: the confusion of the menstrual cycle, 20-90 days, menstrual blood volume chromaticness was without improving, and body weight, abdominal circumference are constant
Or increase, acne is not improved or is increased, and hair increases, especially pubes, red tongue, and moist and slippery fur is greasy, wiry and frequent pulse.
Symptom is not improved, and endocrine and gynecological's color ultrasound present polycystic ovarian syndrome typical characteristic.
TCM syndrome comparitive study before and after 2.2 treatments
Table 1 TCM syndrome comparitive study
Two, model case
Case 1.
First visit: 2015-12-25, river XX, female, 19 years old, 13 years old, 4-7/40-90, menstrual blood volume can, color
Dim, slight dysmenorrhea is with soreness of waist and knee joint；Hirsutism, acne, central obesity；Red tongue, moist and slippery fur is greasy, thready pulse
Number；2015-12-20 (MC:3) endocrine is shown: FSH:5.18miu/mL, LH:24.73miu/mL, PRL:
10.23ng/mL, E2.49pg/ml, T:2.1ng/ml, P:0.98ng/ml；2015-12-25 gynecological color ultrasound
Show: bilateral ovaries a diameter of 2～follicle >=20 piece of 8mm.
Tcm diagnosis: menstruation postponement (phlegm-damp of suffering from a deficiency of the kidney card) Western medicine diagnose: polycystic ovarian syndrome
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the present invention capsule that disappears: Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei
15g, Fructus Aurantii Immaturus 12g, Rhizoma Pinelliae 9g, Arisaema Cum Bile 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Herba cuscutae
Sub-15g, Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae Preparata 6g.14 doses, be decocted in water for oral dose, day potion.
Two examine: 2016-01-13 readme medicine-feeding is the most capable, without significant discomfort symptom.Because of examination nearly, insomnia is received
Difference, symptom of diarrhea is obvious.Body of the tongue is light red, and moist and slippery fur is greasy, stringy and thready pulse.
Tcm diagnosis: diarrhoea (syndrome of phlegm-dampness due to spleen deficiency) Western medicine diagnose: irritability syndrome
The rule for the treatment of: spleen reinforcing eliminating phlegm and removing dampness
Side's medicine: top adds Semen Ziziphi Spinosae 10g, Cortex Albiziae 10g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Radix Codonopsis 15g.7 doses, decocting
Clothes, day potion.
Three examine: 2016-01-22 LMP:2016-01-21, hyper-menorrhea, and color is dim, has clot, the most bitterly
Warp, abdominal pain diarrhea transference cure, red tongue, white, slippery and moist fur, stringy and thready pulse.2016-01-22 (MC:2) endocrine is shown:
FSH:4.28miu/mL, LH:11.33miu/mL, PRL:8.23ng/mL, E13.49pg/ml, T:2.1ng/ml,
P:1.88ng/ml；2015-12-25 gynecological color ultrasound is shown: bilateral ovaries a diameter of 2～follicle >=20 of 8mm
Piece.
Tcm diagnosis: menstruation postponement (phlegm-damp of suffering from a deficiency of the kidney card) Western medicine diagnose: polycystic ovarian syndrome
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the present invention capsule that disappears: Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei
15g, Fructus Aurantii Immaturus 12g, Rhizoma Pinelliae 9g, Arisaema Cum Bile 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Herba cuscutae
Sub-15g, Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae Preparata 6g.14 doses, be decocted in water for oral dose, day potion.
Because of patient's household other places, medical inconvenience, therefore advise after menstruation is clean above it and take, be used in conjunction March.Rear phone
With examining, patient menstrual's more rule, 30-35 day a line, measure chromaticness, painless warp, body weight, waistline are equal
Reducing, acne disappears.
Case 2.
First visit: 2015-09-10 money XX, female, 28 years old, 12 years old, 3-6/30-50, menstrual blood volume can, color
Dim, through row diarrhoea, with soreness of the waist and knees, the unpregnancy 2 years of not practising contraception after marriage；Hirsutism, obesity；Red tongue, tongue
Yellow greasy, thready and rapid pulse；2016-03-10 (MC:4) endocrine is shown: FSH:6.238miu/mL, LH:27.34miu/mL,
PRL:9.12ng/mL, E:3.12pg/ml, T:2.3ng/ml, P:0.88ng/ml；2016-03-11 gynecological
Color ultrasound is shown: bilateral ovaries a diameter of 2～follicle >=20 piece of 8mm.
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, primary infertility
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the present invention capsule that disappears
Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei 15g, Fructus Aurantii Immaturus 12g, Rhizoma Pinelliae 9g, gallbladder
Rhizoma Arisaematis 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Semen Cuscutae 15g, Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae
15g, Radix Glycyrrhizae Preparata 6g.14 doses, be decocted in water for oral dose, day potion.
Two examine: 2015-09-25 medical history is the same, and readme medicine-feeding is the most capable, and during readme is taken medicine, gastric acid vomiting is obvious,
Diet reduces.Body of the tongue is light red, and moist and slippery fur is greasy, stringy and thready pulse.Today, row urine HCG measured: negative.
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) 3, vomiting (expectorant are postponed in menstruation
Drink internal resistance card)
Western medicine diagnose: 1, polycystic ovarian syndrome 2, primary infertility 3, chronic gastritis
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: Xiao Nangyu heir Tonga Rhizoma Pinelliae 10g of the present invention, Rhizoma Zingiberis Recens juice 12g, Poria 9g, Rhizoma Atractylodis Macrocephalae 12g.
Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei 15g, Fructus Aurantii Immaturus 12g, Rhizoma Pinelliae 9g, gallbladder
Rhizoma Arisaematis 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Semen Cuscutae 15g, Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae
15g, Radix Glycyrrhizae Preparata 6g Rhizoma Pinelliae 10g, Rhizoma Zingiberis Recens juice 12g, Poria 9g, Rhizoma Atractylodis Macrocephalae 12g.14 doses, it is decocted in water for oral dose, day
Potion.
Three examine: 2015-10-11 (MC:3) LMP:2015-10-09 medical history is the same, and readme medicine-feeding is the most capable,
Take medicine period without significant discomfort.Hyper-menorrhea, color is dim red, has clot, slight dysmenorrhea, gastric acid symptoms of emesis
Disappear, red tongue, white, slippery and moist fur, stringy and thready pulse.
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, primary infertility
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the capsule that disappears: Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei 15g, trifoliate orange
Real 12g, Rhizoma Pinelliae 9g, Arisaema Cum Bile 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Semen Cuscutae 15g,
Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae Preparata 6g.14 doses, be decocted in water for oral dose, day potion.
Other medical order treatment: 1, survey BBT 2, clomiphene 50mg qd po*5 days 3, letrozole 25mg bid
Po*5 days 4, benefit 1 bid po of extract oral liquid further consultation on the 4,10.23rd
The four diagnostic methods: 2015-10-23 medical history is the same, readme medicine-feeding is the most capable, and period of taking medicine is without significant discomfort.Today
Both transvaginal ultrasonography shows: 2,1.5*1.6 follicle in left ovary；In right ovary, 2-8mm is more than 20.
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, primary infertility
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the present invention capsule that disappears: Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei
15g, Fructus Aurantii Immaturus 12g, Rhizoma Pinelliae 9g, Arisaema Cum Bile 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Herba cuscutae
Sub-15g, Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae Preparata 6g.
Other medical order treatment: 1, survey BBT 2, benefit 1 bid po 3 of extract oral liquid, HCG8000 unit im
Qd st the same branch of a family on the 4,23,24,26th further consultation on the 5,27th
Five examine: 2015-10-27 medical history is the same, and readme medicine-feeding is the most capable, and period of taking medicine is without significant discomfort.Today
Both transvaginal ultrasonography shows: in left ovary, 2-8mm follicle is more than 20；In right ovary, 2-8mm is more than 20
Individual, the more liquid of rear vault.
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, primary infertility
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the present invention capsule that disappears: Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei
15g, Fructus Aurantii Immaturus 12g, Rhizoma Pinelliae 9g, Arisaema Cum Bile 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Herba cuscutae
Sub-15g, Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae Preparata 6g
Other medical order treatment: 1, survey BBT 2, benefit 1 bid po 3 of extract oral liquid, progesterone capsule 3
Grain qdpo*12 4,1 bag of tid po*12 of Strengthen kidney for fetus soothing ball survey urine HCG after 5, two weeks, positive, then further consultation
Prevent miscarriage；Feminine gender, then further consultation in menstrual period.
Six examine: 2015-11-16 (MC:3) LMP:2015-11-14 hyper-menorrhea, color is dim, has blood
Block, not dysmenorrhea, abdominal pain diarrhea transference cure, red tongue, white, slippery and moist fur, stringy and thready pulse.Medical history is the same, in readme
Medicine is the most capable, and period of taking medicine is without significant discomfort.Today, endocrine showed: FSH:4.18miu/mL, LH:
8.34miu/mL, PRL:11.12ng/mL, E:5.22pg/ml, T:4.3ng/ml, P:1.28ng/ml；
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, primary infertility
Other medical order treatment: 1, survey BBT 2, clomiphene 50mg qd po*5 days 3, letrozole 25mg bid
Po*5 days 4, benefit 1 bid po of extract oral liquid further consultation on the 4,10.23rd
Because of patient's household other places, medical inconvenience, advise the monitoring follicular development of its local hospital to and guide the same branch of a family, pregnant after
Prevent miscarriage.Patient's local hospital monitoring follicle March, unpregnancy, the continuous clothes of Chinese medicine.
Seven examine: 2016-03-23 medical history is the same, and readme medicine-feeding is the most capable, and period of taking medicine is without significant discomfort.Readme
The nearly two days stomachache soreness of waist, vagina bleeds on a small quantity, and poor appetite, body of the tongue is light red, white and thin fur, stringy and thready pulse.3.21 day
Test oneself and urinate HCG: the weak positive.Today blood value: E2:289pg/ml P:16.33ng/ml HCG:236mIu/mL
Tcm diagnosis: 1, early pregnancy？2, frequent fetal movement (nephrasthenia syndrome)？
Western medicine diagnose: 1, early pregnancy？2, threatened abortion？
Process:
The traditional Chinese medical science processes: ginseng stilbene SHOUTAI WAN side: Rhizoma Cyperi (processed with vinegar) 12g, Rhizoma Atractylodis Macrocephalae (parched with bran) 12g, Radix Astragali 15g, Cortex Eucommiae(processed with salt)
15g, Colla Corii Asini 11g, Semen Cuscutae 15g, prepared RADIX DIPSACI with salt solution 15g, Radix Paeoniae Alba (parched) 15g, Radix Scutellariae 12g, Radix Codonopsis 15g,
Herba Visci 15g.7 doses, be decocted in water for oral dose, day potion.
Other medical order treatment: 1,1 qd of Muhivitamin Formula With Minerals po*7 days 2, Progesterone 20mg im Qd*7 days 3,
2 qd of progesterone capsule po*7 days
Case 3.
First visit: 2016-03-03, king XX, female, 36 years old, 13 years old, 3-8/35-70 days, menstrual blood volume can,
Color is scarlet, a small amount of clot, suffers from abdominal pain with diarrhoea through property；Do not practise contraception after marriage the most pregnant 2 years；Acne, obesity；
Red tongue, moist and slippery fur is greasy, thready and rapid pulse.2016-04-10 (MC:2) endocrine is shown: FSH:4.23miu/mL,
LH:17.41miu/mL, PRL:7.90ng/mL, E:4.56pg/ml, T:2.2ng/ml, P:0.76ng/ml；
Gynecological's color ultrasound is shown: bilateral ovaries a diameter of 2～follicle >=20 piece of 8mm.
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, secondary infertility
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the present invention capsule that disappears: Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei
15g, Fructus Aurantii Immaturus 12g, Rhizoma Pinelliae 9g, Arisaema Cum Bile 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Herba cuscutae
Sub-15g, Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae Preparata 6g.21 doses, be decocted in water for oral dose, day potion.
Two examine: 2016-04-01 medical history is the same, and readme medicine-feeding is the most capable, without significant discomfort.Today, row urinated HCG
Measure: negative.LMP:2015-03-30 hyper-menorrhea, color is dim, has clot, not dysmenorrhea, abdominal pain diarrhea
Transference cure, red tongue, white, slippery and moist fur, stringy and thready pulse.Medical history is the same, and readme medicine-feeding is the most capable, and period of taking medicine is without bright
Aobvious discomfort.Today, endocrine showed: FSH:4.18miu/mL, LH:7.34miu/mL, PRL:15.22ng/mL,
E:8.42pg/ml, T:2.8ng/ml, P:2.18ng/ml；
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, secondary infertility
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the present invention capsule that disappears: Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei
15g, Fructus Aurantii Immaturus 12g, Rhizoma Pinelliae 9g, Arisaema Cum Bile 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Herba cuscutae
Sub-15g, Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae Preparata 6g.14 doses, be decocted in water for oral dose, day potion.
Three examine: 2016-04-15 medical history is the same, and readme medicine-feeding is the most capable, without significant discomfort.Today both transvaginal ultrasonography
Display: 1,1.8*1.6 follicle in left ovary, 2-8mm follicle is more than 20；2-8mm in right ovary
More than 20.
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, secondary infertility
The rule for the treatment of: the kidney invigorating is reduced phlegm, promoting blood circulation to restore menstrual flow
Side's medicine: heir's soup educated by the capsule that disappears: Fluoritum 24g, processs Herba Epimedii 12g, Rhizoma Atractylodis 15g, Rhizoma Acori Graminei 15g, trifoliate orange
Real 12g, Rhizoma Pinelliae 9g, Arisaema Cum Bile 6g, Cornu Cervi Degelatinatum 15g, Fructus Trichosanthis 15g, Fructus Leonuri 18g, Semen Cuscutae 15g,
Rhizoma Cyperi (processed) 15g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae Preparata 6g
Other medical order treatment: 1, survey BBT 2, benefit 1 bid po 3 of extract oral liquid, HCG10000 unit im
Qd st the same branch of a family on the 4,16,17,19th further consultation on the 5,20th
The four diagnostic methods: 2016-04-20 medical history is the same, readme medicine-feeding is the most capable, and period of taking medicine is without significant discomfort.Today
Both transvaginal ultrasonography shows: in left ovary, 2-8mm follicle is more than 20；In right ovary, 2-8mm is more than 20
Individual, the more liquid of rear vault.
Tcm diagnosis: 1, (phlegm-damp of suffering from a deficiency of the kidney card) 2, infertility (renal deficiency type) are postponed in menstruation
Western medicine diagnose: 1, polycystic ovarian syndrome 2, secondary infertility
Other medical order treatment: 1, survey BBT 2, benefit 1 bid po 3 of extract oral liquid, progesterone capsule 3
Grain qdpo*12 4,1 bag of tid po*12 of Strengthen kidney for fetus soothing ball survey urine HCG after 5, two weeks, positive, then further consultation
Prevent miscarriage；Feminine gender, then further consultation in menstrual period.
Five examine: 2016-05-08 medical history is the same, and readme medicine-feeding is the most capable, and period of taking medicine is without significant discomfort.Readme
The nearly two days stomachache soreness of waist, vagina bleeds on a small quantity, and poor appetite, body of the tongue is light red, white and thin fur, stringy and thready pulse.5.05 day
Test oneself and urinate HCG: the weak positive.Today blood value: E2:254pg/ml P:19.73ng/ml HCG:463mIu/mL
Tcm diagnosis: 1, early pregnancy？2, frequent fetal movement (nephrasthenia syndrome)？
Western medicine diagnose: 1, early pregnancy？2, threatened abortion？
Process:
The traditional Chinese medical science processes: ginseng stilbene SHOUTAI WAN side: Rhizoma Cyperi (processed with vinegar) 12g, Rhizoma Atractylodis Macrocephalae (parched with bran) 12g, Radix Astragali 15g, Cortex Eucommiae(processed with salt)
15g, Colla Corii Asini 11g, Semen Cuscutae 15g, prepared RADIX DIPSACI with salt solution 15g, Radix Paeoniae Alba (parched) 15g, Radix Scutellariae 12g, Radix Codonopsis 15g,
Herba Visci 15g.7 doses, be decocted in water for oral dose, day potion.
Other medical order treatment: 1,1 qd of Muhivitamin Formula With Minerals po*7 days 2, Progesterone 20mg im Qd*7 days 3,
2 qd of progesterone capsule po*7 days.
Detailed description of the invention
In order to make those skilled in the art be more fully understood that the present invention program, below in conjunction with specific embodiment party
The present invention is described in further detail for formula.
Embodiment 1. 1 kinds treats the Chinese medicine composition of polycystic ovarian syndrome, including the crude drug of following component:
Fluoritum 24 grams, processs Herba Epimedii 12 grams, Rhizoma Atractylodis 15 grams, Rhizoma Acori Graminei 15 grams, Fructus Aurantii Immaturus 12 grams, the Rhizoma Pinelliae 9
Gram, Arisaema Cum Bile 6 grams, Cornu Cervi Degelatinatum 15 grams, Fructus Trichosanthis 15 grams, Fructus Leonuri 18 grams, Semen Cuscutae 15 grams, system perfume
Attached 15 grams, Radix Salviae Miltiorrhizae 15 grams, Radix Glycyrrhizae Preparata 6 grams.
Preparation method: medical material clear water soaks half an hour, after big fire is boiled, then slow fire boiling 30 minutes, take
Head is decocted, and adds water and decocts 20 minutes, takes two and decocts, and two decoct and even, and a point morning and evening takes for twice.
Embodiment 2. 1 kinds treats the Chinese medicine composition of polycystic ovarian syndrome, including the crude drug of following component:
Fluoritum 20-30 gram, processs Herba Epimedii 10-15 gram, Rhizoma Atractylodis 10-20 gram, Rhizoma Acori Graminei 10-20 gram, Fructus Aurantii Immaturus
10-15 gram, Rhizoma Pinelliae 6-12 gram, Arisaema Cum Bile 5-10 gram, Cornu Cervi Degelatinatum 10-20 gram, Fructus Trichosanthis 10-20 gram, motherwort
Luxuriant sub-10-20 gram, Semen Cuscutae 10-20 gram, Rhizoma Cyperi (processed) 10-20 gram, Radix Salviae Miltiorrhizae 10-20 gram, Radix Glycyrrhizae Preparata 5-10
Gram.
After above-mentioned medical material is weighed by consumption, after pulverizing 50 mesh sieves, add water and make submergence medical material, soak 3 little
Shi Hou, is heated to boiling, decocts 0.5 hour, take decocting liquid.Medicinal residues decoct 2-3 time in accordance with the law, merge each decocting liquid.
After filtration, evaporation and concentration (1:1), add the ethanol of 1.5 times amount after cooling, fully mix, stand overnight,
Taking supernatant, precipitate is cleaned with a small amount of 50% ethanol, and washing liquid merges with filtrate, after decompression recycling ethanol, concentrates
Cooling stands, and after filtration, vacuum and low temperature is concentrated into thick paste, and thick paste proportion is 1.33, crosses 300 after spray drying
Mesh sieve, makes granule after adding appropriate amount of auxiliary materials.
Embodiment 3. 1 kinds treats the Chinese medicine composition of polycystic ovarian syndrome, including the crude drug of following component:
Fluoritum 20-30 gram, processs Herba Epimedii 10-15 gram, Rhizoma Atractylodis 10-20 gram, Rhizoma Acori Graminei 10-20 gram, Fructus Aurantii Immaturus
10-15 gram, Rhizoma Pinelliae 6-12 gram, Arisaema Cum Bile 5-10 gram, Cornu Cervi Degelatinatum 10-20 gram, Fructus Trichosanthis 10-20 gram, motherwort
Luxuriant sub-10-20 gram, Semen Cuscutae 10-20 gram, Rhizoma Cyperi (processed) 10-20 gram, Radix Salviae Miltiorrhizae 10-20 gram, Radix Glycyrrhizae Preparata 5-10
Gram.
After being weighed by consumption by above-mentioned medical material, all medicines take after 3/5ths of its dose pulverized 50 mesh sieves, add
Water makes submergence medical material, after soaking 3 hours, is heated to boiling, decocts 0.5 hour, take decocting liquid.Medicinal residues are decocted in accordance with the law
Boil 2-3 time, merge each decocting liquid.After filtration, evaporation and concentration (1:1), add the second of 1.5 times amount after cooling
Alcohol, fully mixes, and stands overnight, and takes supernatant, and precipitate is cleaned with a small amount of 50% ethanol, and washing liquid is closed with filtrate
And, after decompression recycling ethanol, concentrating cooling and stand, after filtration, vacuum and low temperature is concentrated into thick paste, thick paste proportion
It is 1.33 spray drying finely ground mistake 300 mesh sieves, obtains extract powder.All medicine surpluses 2/5ths are done in 80 DEG C
Dry rear micronizing, to more than 800 mesh, is filled after mixing homogeneously with extract powder and is made capsule.
Embodiment 4. 1 kinds treats the Chinese medicine composition of polycystic ovarian syndrome, including the crude drug of following component:
Fluoritum 20-30 gram, processs Herba Epimedii 10-15 gram, Rhizoma Atractylodis 10-20 gram, Rhizoma Acori Graminei 10-20 gram, Fructus Aurantii Immaturus
10-15 gram, Rhizoma Pinelliae 6-12 gram, Arisaema Cum Bile 5-10 gram, Cornu Cervi Degelatinatum 10-20 gram, Fructus Trichosanthis 10-20 gram, motherwort
Luxuriant sub-10-20 gram, Semen Cuscutae 10-20 gram, Rhizoma Cyperi (processed) 10-20 gram, Radix Salviae Miltiorrhizae 10-20 gram, Radix Glycyrrhizae Preparata 5-10
Gram.
Preparation method: be dried according to after above-mentioned weight weighting raw materials, microgranule more than micronizing to 800 mesh,
Add after appropriate dextrin stirs and make tablet.
Embodiment 5. 1 kinds treats the Chinese medicine composition of polycystic ovarian syndrome, including the crude drug of following component:
Fluoritum 24 grams, processs Herba Epimedii 12 grams, Rhizoma Atractylodis 15 grams, Rhizoma Acori Graminei 15 grams, Fructus Aurantii Immaturus 12 grams, the Rhizoma Pinelliae 9
Gram, Arisaema Cum Bile 6 grams, Cornu Cervi Degelatinatum 15 grams, Fructus Trichosanthis 15 grams, Fructus Leonuri 18 grams, Semen Cuscutae 15 grams, system perfume
Attached 15 grams, Radix Salviae Miltiorrhizae 15 grams, Radix Glycyrrhizae Preparata 6 grams, Semen Ziziphi Spinosae 10 grams, Cortex Albiziae 10 grams, Rhizoma Atractylodis Macrocephalae (parched) 15 grams,
Radix Codonopsis 15 grams.
Preparation method: medical material clear water soaks half an hour, after big fire is boiled, then slow fire boiling 30 minutes, take
Head is decocted, and adds water and decocts 20 minutes, takes two and decocts, and two decoct and even, and a point morning and evening takes for twice.
Embodiment 6. 1 kinds treats the Chinese medicine composition of polycystic ovarian syndrome, including the crude drug of following component:
Fluoritum 24 grams, processs Herba Epimedii 12 grams, Rhizoma Atractylodis 15 grams, Rhizoma Acori Graminei 15 grams, Fructus Aurantii Immaturus 12 grams, the Rhizoma Pinelliae 9
Gram, Arisaema Cum Bile 6 grams, Cornu Cervi Degelatinatum 15 grams, Fructus Trichosanthis 15 grams, Fructus Leonuri 18 grams, Semen Cuscutae 15 grams, system perfume
Attached 15 grams, Radix Salviae Miltiorrhizae 15 grams, Radix Glycyrrhizae Preparata 6 grams, the Rhizoma Pinelliae 10 grams, Rhizoma Zingiberis Recens juice 12 grams, 9 grams of Poria, the Rhizoma Atractylodis Macrocephalae
12 grams.
Preparation method: medical material clear water soaks half an hour, after big fire is boiled, then slow fire boiling 30 minutes, take
Head is decocted, and adds water and decocts 20 minutes, takes two and decocts, and two decoct and even, and a point morning and evening takes for twice.
Claims (7)
1. treat a Chinese medicine composition for polycystic ovarian syndrome, it is characterized in that, in parts by weight, former including following component
Material medicine: Fluoritum 20-30 part, processs Herba Epimedii 10-15 part, Rhizoma Atractylodis 10-20 part, Rhizoma Acori Graminei 10-20 part, Fructus Aurantii Immaturus 10-15
Part, Rhizoma Pinelliae 6-12 part, Arisaema Cum Bile 5-10 part, Cornu Cervi Degelatinatum 10-20 part, Fructus Trichosanthis 10-20 part, Fructus Leonuri 10-20 part, Herba cuscutae
Sub-10-20 part, Rhizoma Cyperi (processed) 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Radix Glycyrrhizae Preparata 5-10 part.
2. treat the Chinese medicine composition of polycystic ovarian syndrome as claimed in claim 1, it is characterized in that, in parts by weight, including
The crude drug of following component: Fluoritum 24 parts, processs Herba Epimedii 12 parts, Rhizoma Atractylodis 15 parts, Rhizoma Acori Graminei 15 parts, Fructus Aurantii Immaturus 12 parts,
The Rhizoma Pinelliae 9 parts, Arisaema Cum Bile 6 parts, Cornu Cervi Degelatinatum 15 parts, Fructus Trichosanthis 15 parts, Fructus Leonuri 18 parts, Semen Cuscutae 15 parts, Rhizoma Cyperi (processed) 15
Part, Radix Salviae Miltiorrhizae 15 parts, Radix Glycyrrhizae Preparata 6 parts.
3. treat the Chinese medicine composition of polycystic ovarian syndrome as claimed in claim 2, it is characterized in that, in parts by weight, including
The crude drug of following component: Fluoritum 24 parts, processs Herba Epimedii 12 parts, Rhizoma Atractylodis 15 parts, Rhizoma Acori Graminei 15 parts, Fructus Aurantii Immaturus 12 parts,
The Rhizoma Pinelliae 9 parts, Arisaema Cum Bile 6 parts, Cornu Cervi Degelatinatum 15 parts, Fructus Trichosanthis 15 parts, Fructus Leonuri 18 parts, Semen Cuscutae 15 parts, Rhizoma Cyperi (processed) 15
Part, Radix Salviae Miltiorrhizae 15 parts, Radix Glycyrrhizae Preparata 6 parts, Semen Ziziphi Spinosae 10 parts, Cortex Albiziae 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Radix Codonopsis 15 parts.
4. treat the Chinese medicine composition of polycystic ovarian syndrome as claimed in claim 2, it is characterized in that, in parts by weight, including
The crude drug of following component: Fluoritum 24 parts, processs Herba Epimedii 12 parts, Rhizoma Atractylodis 15 parts, Rhizoma Acori Graminei 15 parts, Fructus Aurantii Immaturus 12 parts,
The Rhizoma Pinelliae 9 parts, Arisaema Cum Bile 6 parts, Cornu Cervi Degelatinatum 15 parts, Fructus Trichosanthis 15 parts, Fructus Leonuri 18 parts, Semen Cuscutae 15 parts, Rhizoma Cyperi (processed) 15
Part, Radix Salviae Miltiorrhizae 15 parts, Radix Glycyrrhizae Preparata 6 parts, the Rhizoma Pinelliae 10 parts, Rhizoma Zingiberis Recens juice 12 parts, 9 parts of Poria, the Rhizoma Atractylodis Macrocephalae 12 parts.
5. the Chinese medicine composition of any described treatment polycystic ovarian syndrome of claim 1-4 in preparation prevention and/or treats many capsules ovum
Application in the medicine of nest syndrome.
6. treating the Chinese medicine composition for the treatment of polycystic ovarian syndrome described in claim 5, it is characterized in that, described medicine can be soup
Agent, tablet, granule, powder or capsule.
7. treat the Chinese medicine composition for the treatment of polycystic ovarian syndrome described in claim 6, it is characterized in that, the preparation of described capsule
Method is, after being weighed by consumption by above-mentioned medical material, all medicines take after 3/5ths of its dose pulverized 50 mesh sieves, add water and make submergence
Medical material, after soaking 3 hours, is heated to boiling, decocts 0.5 hour, take decocting liquid；Medicinal residues decoct 2-3 time in accordance with the law, merge each decocting liquid；
After filtration, evaporation and concentration (1:1), add the ethanol of 1.5 times amount after cooling, fully mix, stand overnight, take supernatant, heavy
Shallow lake thing is cleaned with a small amount of 50% ethanol, and washing liquid merges with filtrate, after decompression recycling ethanol, concentrates cooling and stands, after filtration, and vacuum
Cryoconcentration is to thick paste, and thick paste proportion is 1.33 spray drying finely ground mistake 300 mesh sieves, obtains extract powder；All medicine surpluses five points
Two more than 80 DEG C of dried micronizing to 800 mesh, fill after mixing homogeneously with extract powder and make capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610431771.5A CN105853659B (en) | 2016-06-15 | 2016-06-15 | Traditional Chinese medicine composition for treating polycystic ovarian syndrome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610431771.5A CN105853659B (en) | 2016-06-15 | 2016-06-15 | Traditional Chinese medicine composition for treating polycystic ovarian syndrome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105853659A true CN105853659A (en) | 2016-08-17 |
| CN105853659B CN105853659B (en) | 2021-06-18 |
Family
ID=56650807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610431771.5A Active CN105853659B (en) | 2016-06-15 | 2016-06-15 | Traditional Chinese medicine composition for treating polycystic ovarian syndrome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105853659B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334060A (en) * | 2016-11-03 | 2017-01-18 | 山东中医药大学附属医院 | Pharmaceutical composition for treating endomorphy type polycystic ovarian syndrome |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104162057A (en) * | 2014-08-26 | 2014-11-26 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating obese polycystic ovarian syndrome and applications thereof |
| CN104940740A (en) * | 2015-07-01 | 2015-09-30 | 袁明圆 | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method thereof |
| CN105031559A (en) * | 2015-06-18 | 2015-11-11 | 河南中医学院 | Traditional Chinese medicine for treating infertility due to polycystic ovarian syndromes |
| CN105250556A (en) * | 2015-11-13 | 2016-01-20 | 庄小侃 | Traditional Chinese medicine drug for treating polycystic ovarian syndrome |
| CN105477249A (en) * | 2015-12-22 | 2016-04-13 | 江苏省中医院 | Traditional Chinese medicinal composition for treating insulin resistance polycystic ovary syndrome |
-
2016
- 2016-06-15 CN CN201610431771.5A patent/CN105853659B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104162057A (en) * | 2014-08-26 | 2014-11-26 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating obese polycystic ovarian syndrome and applications thereof |
| CN105031559A (en) * | 2015-06-18 | 2015-11-11 | 河南中医学院 | Traditional Chinese medicine for treating infertility due to polycystic ovarian syndromes |
| CN104940740A (en) * | 2015-07-01 | 2015-09-30 | 袁明圆 | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method thereof |
| CN105250556A (en) * | 2015-11-13 | 2016-01-20 | 庄小侃 | Traditional Chinese medicine drug for treating polycystic ovarian syndrome |
| CN105477249A (en) * | 2015-12-22 | 2016-04-13 | 江苏省中医院 | Traditional Chinese medicinal composition for treating insulin resistance polycystic ovary syndrome |
Non-Patent Citations (1)
| Title |
|---|
| 傅超美、刘文: "《中药药剂学实验》", 28 February 2015, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334060A (en) * | 2016-11-03 | 2017-01-18 | 山东中医药大学附属医院 | Pharmaceutical composition for treating endomorphy type polycystic ovarian syndrome |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105853659B (en) | 2021-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101502634B (en) | Chinese medicinal composition for treating uterine blood flow and preparation method thereof | |
| CN101496862B (en) | Chinese medicinal composition for treating infertility and preparation method thereof | |
| CN102247585A (en) | Chinese medicinal composition for treating rheumatism, preparation thereof and preparation method thereof | |
| CN104162094B (en) | A kind of Chinese medicine composition and its pharmaceutical preparation for treating Obesity-type Polycystic Ovary Syndrome | |
| CN101502625B (en) | Chinese medicine for treating women's postpartum syndrome and preparation method thereof | |
| CN104383363A (en) | Traditional Chinese medicinal composition for treating gout | |
| CN109966462A (en) | A kind of herbal paste and preparation method thereof improving constitution | |
| CN103861074A (en) | Traditional Chinese medicinal composition for treating menopausal arthritis | |
| CN104043022A (en) | Traditional Chinese medicine composition for treating gynecologic inflammation | |
| CN109528980A (en) | A kind of Chinese medicine composition and its pharmacy application for treating Ovary reserve decline disease | |
| CN103393989A (en) | Traditional Chinese medicine composition for treating gynecologic inflammation | |
| CN103211899A (en) | Method for treating psoriasis | |
| CN101002873B (en) | Medicine for treating recurrent gout, and its preparing method | |
| CN102274445A (en) | Cassia twig common burreed rhizome tumor eliminating pills | |
| CN103083616B (en) | Traditional Chinese medicine for treating ovarian cyst | |
| CN104857455A (en) | Traditional Chinese medicine preparation for chronic interstitial nephropathy and preparation method thereof | |
| CN104998232A (en) | Dysmenorrhea patch | |
| CN105853659A (en) | Traditional Chinese medicine composition for treating polycystic ovarian syndrome | |
| CN107753880A (en) | A kind of pharmaceutical composition for treating dysmenorrhoea and preparation method thereof | |
| CN101422547B (en) | Traditional Chinese medicine for treating kidney-deficiency blood-insufficiency type amenorrhea | |
| CN104840865A (en) | Traditional Chinese medicine preparation for treating gouty arthritis | |
| CN104840891A (en) | Traditional Chinese medicine preparation used for treating alcoholic cardiomyopathy and preparation method thereof | |
| CN110201122A (en) | A kind of Chinese medicine composition and its preparation method and application for treating irregular menstruation | |
| CN101036742B (en) | Medicine for treating prostatic disease | |
| CN105853978A (en) | Method for preparing medicinal composition for treating female climacteric syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |