CN105853240A - Preparation method of antibacterial tooth repair material - Google Patents
Preparation method of antibacterial tooth repair material Download PDFInfo
- Publication number
- CN105853240A CN105853240A CN201610347352.3A CN201610347352A CN105853240A CN 105853240 A CN105853240 A CN 105853240A CN 201610347352 A CN201610347352 A CN 201610347352A CN 105853240 A CN105853240 A CN 105853240A
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- Prior art keywords
- repair material
- mixture
- preparation
- antibacterial
- antioxidant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/898—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/84—Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/891—Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/891—Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61K6/896—Polyorganosilicon compounds
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- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dental Preparations (AREA)
Abstract
The invention discloses a preparation method of an antibacterial tooth repair material. A raw material is firstly weighed, and a part of the raw material is added to a mixing machine and is evenly stirred to obtain a mixture; then, the mixture is subjected to ultrasonic wave crushing; finally, another part of the raw material is added to the mixture subjected to ultrasonic wave crushing, finally the residual raw material is added, stirring is performed till the mixture changes into uniform paste, and the antibacterial tooth repair material can be obtained. The antibacterial tooth repair material prepared by adopting the scheme improves tissue compatibility and blood compatibility, has antibacterial properties, improves mechanic, mechanical and physical properties, is not easily abraded and is durable. The preparation method of the antibacterial tooth repair material has the advantages of being simple in process, easy to operate, high in yield, small in environmental pollution and the like.
Description
Technical field
The present invention relates to the preparation method of a kind of antibacterial dental repair material.
Technical background
Tooth is the organ of mankind's laboratory rodent chow.Tooth is the organ that human body is the hardest.It is said that in general, tooth is white, quality is hard.The variously-shaped of tooth is applicable to multiple use, including tear, grate foods.Human language pronunciation is closely related with the upper and lower tooth in front row in mouth.Tooth is organ the hardest in human body, is divided into corona, neck and root of the tooth three part.It is divided into again enamel, dentin, dental pulp etc..It is mainly composed of calcium hydroxy phosphate: i.e. alkali calcium phosphate, the key component of human teeth.
Dental caries is commonly called as dental caries, decayed tooth, is bacterial disease, even can cause alveolar bone and inflammation of jaws with secondary pulpitis and periapical periodontitis.As treated not in time, pathological changes continues development, forms cavity, destroys disappearance eventually to corona completely, and the final result of its development is loss of tooth.Untreated cavity will not self-heal, its development final result be loss of tooth.Dental caries is bacterial disease, and therefore it even can cause alveolar bone and inflammation of jaws with secondary pulpitis and periapical periodontitis.The method that treatment dental caries uses is mainly filling, will remove clean by the bad tissue of dental caries, be made certain hole shape, after cleaning, sterilizing, fills with filler, and recovers the profile of tooth defect.The most shallow dental caries filling effect is best, middle dental caries and the treatment of deep dental caries, after removing the bad tissue of dental caries, sometimes close to dental pulp at the bottom of hole, it is necessary to protect marrow agent refill adding one layer at the bottom of hole.Sometimes deep dental caries dental pulp after removing the bad tissue of dental caries just exposes, it is necessary to first takes endodontic treatment, then could fill.Filler is mainly with silver amalgam or complex filling gum.
Composite resin, compared with the repair materials such as Silver amalgam, has excellent biology, performance mechanical and attractive in appearance, it has also become the topmost mode of current various tissue of tooth defect repair.But microenvironment is complicated, and influence factor is numerous.The graduate survey result of US National dentistry shows: existing resin dummy more than 50% needs to change, and the clinical life of resin bonding dummy was less than 6 years, and only the U.S. is every year for changing the spending the most up to 5,000,000,000 dollars of the vertex-gluing graph body of defect.Formed firm and lasting bonding between resin material with tissue of tooth, be the determiner determining resin dummy service life, but either hat side still root pipe dentin, the problem that all there is long-term bonding instability.
In prior art, the phenomenon that the implant being filled in tooth often falls off due to the effect of external force, the most not only make troubles to patient, there is also bigger economic loss simultaneously.Since 20th century invention sixties photocuring dental resin material, this class material, due to attractive in appearance nontoxic, easy to use, develops very fast.But owing to occurring volume contraction in dental resin polymerization process, the sickness rate of patient's Secondary cases dental caries is higher, and the abrasive resistance of macromolecule resin and mechanical strength limited, therefore significantly limit the service life of dental resin material.Along with dental materials understanding is deepened by people, develop a kind of high abrasion, mechanical strength is big, cubical contraction is little novel dental resin material is particularly important.
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that a kind of not only easily machine-shaping but also meet the preparation method of antibacterial dental repair material of requirement of strength.
It is an object of the invention to be achieved through the following technical solutions: the preparation method of a kind of antibacterial dental repair material, said method comprising the steps of: first weigh each raw material of following weight parts: epoxy resin 50-88 part, sodium carboxymethyl cellulose 10-25 part, antioxidant 5-12 part, Ethylene glycol dimethacrylate 4-10 part, silver source compound 5-10 part, silicone rubber particles 6-9 part, polyacrylic acid N-butyl 10-16 part, k eratin 6-15 parts, propylene glycol alginate 4-15 part, inorganic filler 4-5 part, consisting of phase-transferring agent 4-8 part, calcium polyphosphate 10-15 part, will be except Ethylene glycol dimethacrylate, antioxidant, silver source compound, each raw material beyond keratin and sodium carboxymethyl cellulose adds in mixer, mixture is obtained after stirring；Then by mixture power at ultrasonic disruption 1-2 hour of 50-55W；Again Ethylene glycol dimethacrylate, antioxidant and silver source compound are added in the mixture after ultrasonic disruption, temperature be 65-72 DEG C, rotating speed be 500-600 rev/min under the conditions of stir 0.5-1h, it is eventually adding keratin and sodium carboxymethyl cellulose, temperature be 25-37 DEG C, under the conditions of rotating speed is 900-1200 rev/min, stirring can be prepared by antibacterial dental repair material when being uniform paste body shape to mixture.
Described inorganic filler is calcium phosphate.
Described silver source compound is actol.
Described consisting of phase-transferring agent is positive tetrabutyl ammonium bromide.
Described antioxidant is dibenzylatiooluene.
Beneficial effect: scheme of the present invention is prepared antibacterial dental repair material and improved histocompatibility and blood compatibility；There is antibiotic property, improve and improve mechanics, machinery, physical property, the most easy to wear durable；It is simple that its preparation method has technique, easily operates, and productivity is high, the advantages such as environmental pollution is little.
Detailed description of the invention
Embodiment
1
A kind of preparation method of antibacterial dental repair material, said method comprising the steps of: first weigh each raw material of following weight parts: epoxy resin 50 parts, sodium carboxymethyl cellulose 10 parts, 5 parts of antioxidant, Ethylene glycol dimethacrylate 4 parts, silver source compound 5 parts, silicone rubber particles 6 parts, polyacrylic acid N-butyl 10 parts, k eratin 6 part, propylene glycol alginate 4 parts, inorganic filler 4 parts, consisting of phase-transferring agent 4 parts, calcium polyphosphate 10 parts, will be except Ethylene glycol dimethacrylate, antioxidant, silver source compound, each raw material beyond keratin and sodium carboxymethyl cellulose adds in mixer, mixture is obtained after stirring；Then by mixture power at ultrasonic disruption 1-2 hour of 50-55W；Again Ethylene glycol dimethacrylate, antioxidant and silver source compound are added in the mixture after ultrasonic disruption, temperature be 65-72 DEG C, rotating speed be 500-600 rev/min under the conditions of stir 0.5-1h, it is eventually adding keratin and sodium carboxymethyl cellulose, temperature be 25-37 DEG C, under the conditions of rotating speed is 900-1200 rev/min, stirring can be prepared by antibacterial dental repair material when being uniform paste body shape to mixture.Wherein inorganic filler is calcium phosphate.Silver source compound is actol.Consisting of phase-transferring agent is positive tetrabutyl ammonium bromide.Antioxidant is dibenzylatiooluene.
Embodiment
2
A kind of preparation method of antibacterial dental repair material, said method comprising the steps of: first weigh each raw material of following weight parts: epoxy resin 88 parts, sodium carboxymethyl cellulose 25 parts, 12 parts of antioxidant, Ethylene glycol dimethacrylate 10 parts, silver source compound 10 parts, silicone rubber particles 6-9 part, polyacrylic acid N-butyl 16 parts, keratin 15 part, propylene glycol alginate 15 parts, inorganic filler 5 parts, consisting of phase-transferring agent 8 parts, calcium polyphosphate 15 parts, will be except Ethylene glycol dimethacrylate, antioxidant, silver source compound, each raw material beyond keratin and sodium carboxymethyl cellulose adds in mixer, mixture is obtained after stirring；Then by mixture power at ultrasonic disruption 1-2 hour of 50-55W；Again Ethylene glycol dimethacrylate, antioxidant and silver source compound are added in the mixture after ultrasonic disruption, temperature be 65-72 DEG C, rotating speed be 500-600 rev/min under the conditions of stir 0.5-1h, it is eventually adding keratin and sodium carboxymethyl cellulose, temperature be 25-37 DEG C, under the conditions of rotating speed is 900-1200 rev/min, stirring can be prepared by antibacterial dental repair material when being uniform paste body shape to mixture.Wherein inorganic filler is calcium phosphate.Silver source compound is actol.Consisting of phase-transferring agent is positive tetrabutyl ammonium bromide.Antioxidant is dibenzylatiooluene.
Embodiment
3
A kind of preparation method of antibacterial dental repair material, said method comprising the steps of: first weigh each raw material of following weight parts: epoxy resin 68 parts, sodium carboxymethyl cellulose 18 parts, 8 parts of antioxidant, Ethylene glycol dimethacrylate 7 parts, silver source compound 7 parts, silicone rubber particles 8 parts, polyacrylic acid N-butyl 13 parts, Keratin 11 part, propylene glycol alginate 9 parts, inorganic filler 4 parts, consisting of phase-transferring agent 6 parts, calcium polyphosphate 13 parts, will be except Ethylene glycol dimethacrylate, antioxidant, silver source compound, each raw material beyond keratin and sodium carboxymethyl cellulose adds in mixer, mixture is obtained after stirring；Then by mixture power at ultrasonic disruption 1-2 hour of 50-55W；Again Ethylene glycol dimethacrylate, antioxidant and silver source compound are added in the mixture after ultrasonic disruption, temperature be 65-72 DEG C, rotating speed be 500-600 rev/min under the conditions of stir 0.5-1h, it is eventually adding keratin and sodium carboxymethyl cellulose, temperature be 25-37 DEG C, under the conditions of rotating speed is 900-1200 rev/min, stirring can be prepared by antibacterial dental repair material when being uniform paste body shape to mixture.Wherein inorganic filler is calcium phosphate.Silver source compound is actol.Consisting of phase-transferring agent is positive tetrabutyl ammonium bromide.Antioxidant is dibenzylatiooluene.
The resin composite materials preparing above-described embodiment 1-3 carries out following test, and above-described embodiment prepares composite and meets the mechanical property requirements of dental resin material, and reduces cubical contraction to a certain extent；This material is through antibacterial test simultaneously, to the antibiotic rate of staphylococcus aureus more than 99%.
Claims (5)
1. the preparation method of an antibacterial dental repair material, it is characterized in that, said method comprising the steps of: first weigh each raw material of following weight parts: epoxy resin 50-88 part, sodium carboxymethyl cellulose 10-25 part, antioxidant 5-12 part, Ethylene glycol dimethacrylate 4-10 part, silver source compound 5-10 part, silicone rubber particles 6-9 part, polyacrylic acid N-butyl 10-16 part, k eratin 6-15 parts, propylene glycol alginate 4-15 part, inorganic filler 4-5 part, consisting of phase-transferring agent 4-8 part, calcium polyphosphate 10-15 part, will be except Ethylene glycol dimethacrylate, antioxidant, silver source compound, each raw material beyond keratin and sodium carboxymethyl cellulose adds in mixer, mixture is obtained after stirring；Then by mixture power at ultrasonic disruption 1-2 hour of 50-55W；Again Ethylene glycol dimethacrylate, antioxidant and silver source compound are added in the mixture after ultrasonic disruption, temperature be 65-72 DEG C, rotating speed be 500-600 rev/min under the conditions of stir 0.5-1h, it is eventually adding keratin and sodium carboxymethyl cellulose, temperature be 25-37 DEG C, under the conditions of rotating speed is 900-1200 rev/min, stirring can be prepared by antibacterial dental repair material when being uniform paste body shape to mixture.
The preparation method of a kind of antibacterial dental repair material the most according to claim 1, it is characterised in that: described inorganic filler is calcium phosphate.
The preparation method of a kind of antibacterial dental repair material the most according to claim 1, it is characterised in that: described silver source compound is actol.
The preparation method of a kind of antibacterial dental repair material the most according to claim 1, it is characterised in that: described consisting of phase-transferring agent is positive tetrabutyl ammonium bromide.
The preparation method of a kind of antibacterial dental repair material the most according to claim 1, it is characterised in that: described antioxidant is dibenzylatiooluene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610347352.3A CN105853240A (en) | 2016-05-24 | 2016-05-24 | Preparation method of antibacterial tooth repair material |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610347352.3A CN105853240A (en) | 2016-05-24 | 2016-05-24 | Preparation method of antibacterial tooth repair material |
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| Publication Number | Publication Date |
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| CN105853240A true CN105853240A (en) | 2016-08-17 |
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| CN201610347352.3A Pending CN105853240A (en) | 2016-05-24 | 2016-05-24 | Preparation method of antibacterial tooth repair material |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209228A (en) * | 2006-12-27 | 2008-07-02 | 华东理工大学 | Antibiotic dental prosthetic materials and preparation method thereof |
| WO2010081104A1 (en) * | 2009-01-10 | 2010-07-15 | Medical College Of Georgia Research Institute, Inc. | Use of polymeri zable quaternary ammonium compounds to inhibit endogenous mmps in tooth dentin |
| CN105232339A (en) * | 2015-10-14 | 2016-01-13 | 苏州蔻美新材料有限公司 | Antibacterial and durable tooth filling composite material and preparation method thereof |
| CN105232340A (en) * | 2015-10-14 | 2016-01-13 | 苏州蔻美新材料有限公司 | Composite material for dental prosthesis and preparation method of composite material |
-
2016
- 2016-05-24 CN CN201610347352.3A patent/CN105853240A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209228A (en) * | 2006-12-27 | 2008-07-02 | 华东理工大学 | Antibiotic dental prosthetic materials and preparation method thereof |
| WO2010081104A1 (en) * | 2009-01-10 | 2010-07-15 | Medical College Of Georgia Research Institute, Inc. | Use of polymeri zable quaternary ammonium compounds to inhibit endogenous mmps in tooth dentin |
| CN105232339A (en) * | 2015-10-14 | 2016-01-13 | 苏州蔻美新材料有限公司 | Antibacterial and durable tooth filling composite material and preparation method thereof |
| CN105232340A (en) * | 2015-10-14 | 2016-01-13 | 苏州蔻美新材料有限公司 | Composite material for dental prosthesis and preparation method of composite material |
Non-Patent Citations (1)
| Title |
|---|
| 韩科 等: "《口腔技工学》", 31 December 2009, 北京大学医学出版社 * |
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Application publication date: 20160817 |
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