CN105852832A - Blood pressure real-time measurement device and method for measuring mean blood pressure - Google Patents
Blood pressure real-time measurement device and method for measuring mean blood pressure Download PDFInfo
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- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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Abstract
The invention relates to a blood pressure real-time measurement device which comprises a first position pulse wave induction module, a second position pulse wave induction module and a signal processing module, wherein the first position pulse wave induction module comprises a first position first pulse wave induction module and a first position second pulse wave induction module; the second position pulse wave induction module comprises a second position first pulse wave induction module and a second position second pulse wave induction module; the signal processing module is used for calculating a first transmission signal difference delta tA between a first pulse wave signal A1 and a second pulse wave signal A2 of the first position and a second transmission signal difference delta tB between a first pulse wave signal B1 and a second pulse wave signal B2 of the second position, and obtaining mean blood pressure (MBP) of each cardiac cycle according to a difference delta t between the first transmission signal difference delta tA and the second transmission signal difference delta tB. The invention further relates to a method for measuring the mean blood pressure.
Description
Technical field
The present invention relates to the measuring method of a kind of blood pressure measuring device and mean blood pressure, particularly relate to a kind of blood
Pressure noinvasive, continuous, real-time measurement apparatus and measuring method.
Background technology
Cardiovascular disease is current developed country and the lethal main cause of developing country crowd.Hypertension
It is one of most important risk factor of cardiovascular and cerebrovascular disease, the apoplexy of 50%～70% and 40%～50%
Myocardial infarction betides blood pressure and raises relevant.The monitoring of blood pressure is for the prevention and in early days of cardiovascular and cerebrovascular disease
Find and treatment important role.Therefore, it is achieved the noinvasive of blood pressure is measured continuously, to health supervision and
Clinical research is significant.
Traditional is relatively based on pulse wave transmission time (Pulse Transit Time, PTT) measurement blood pressure
For universal non-invasive blood pressure method for continuous measuring, it is widely used on wearable device and carries out blood pressure measurement.
Its core concept is that the pulse wave according to electrocardiogram (ECG) and arterial distal obtains PTT, and PTT
There is stronger dependency with blood pressure, therefore can be calculated pressure value according to the PTT recorded.But
It is that blood pressure measuring method based on PTT needs to measure electrocardiosignal and pulse wave signal simultaneously.And the heart
The signal of telecommunication needs at human body multiple position fixed electrode, needs many electrical leads, causes measuring inconvenience.
And electrocardioelectrode is in use for some time it cannot be guaranteed that contact well with skin, it is unsuitable for long-time
(such as 24 hours/7 days) monitors blood pressure continuously.
The phase contrast (Phase Difference of Pulse Waves, PDPW) of pulse wave is the newest
The concept being suggested, refers to that two different kinds of pulse wave is (such as pressure pulse wave and volume pulsation
Ripple), due to the difference of spread speed, start to travel to the phase place that the same position of tremulous pulse is formed from ventricle
Difference.It is embodied as the time difference between two kinds of pulse wave characteristic points.The time difference of pulse wave contains rich
Rich information, itself may be used for non-invasive blood pressure and measures.
Prior art carries out phase difference measurement by single position, but, owing to measuring process to sensing
The position that device is placed is very sensitive, and during twice measurement, the minor variations of sensing station is required for again coming
Demarcating, complex operation, cause existing error, the blood pressure accuracy at institute's calculating has much room for improvement.
Summary of the invention
In view of this, necessary offer a kind of noinvasive, blood pressure measuring device continuous, real-time, accurate
And measuring method.
A kind of blood pressure real-time measurement apparatus, it is characterised in that including: a first position pulse wave sensing
Module, including first position the first pulse wave induction module and first position the second pulse wave sense
Answer module, to sense the different types of pulse wave signal of first position；One second position pulse wave sense
Answer module, including second position the first pulse wave induction module and second position second pulse wave
Induction module, to sense the different types of pulse wave signal of second position；And a signal processing module,
For the first pulse wave signal A that first position the first pulse wave induction module is sensed1, primary importance
Locate the second pulse wave signal A of the second pulse wave induction module sensing2, second position the second pulse wave sense
Answer the first pulse wave signal B that module senses1And the sensing of second position the second pulse wave induction module
Second pulse wave signal B2Process, and calculate the first pulse wave signal A1With the second pulse wave signal
A2Between first transmission signal difference Δ tA, and the first pulse wave signal B1With the second pulse wave signal
B2Between second transmission signal difference Δ tB, simultaneously according to the first transmission signal difference Δ tAWith the second transmission letter
Number difference Δ tBBetween poor Δ t, it is thus achieved that tremulous pulse mean blood pressure MBP of each cardiac cycle.
First position pulse wave inductive module and described second position pulse wave inductive module are two
Identical module, is respectively arranged at different sensed positions, to obtain each cardiac cycle of various location
Pulse wave signal.
Described different types of pulse wave signal is selected from pressure pulse wave, photoplethysmographic or Hemodynamic environment
Degree pulse wave.
Described first position the first pulse wave signal A1With second position the first pulse wave signal B1For
The pulse wave signal of same type, described first position the second pulse wave signal A2With second position
Second pulse wave signal B2Pulse wave signal for same type.
Described first position pulse wave inductive module farther includes one first D/A converter module, is used for
To first position the first pulse wave signal A1With first position the second pulse wave signal A2Filter
Ripple, signal amplify and analog digital conversion, and the signal after conversion is transferred to signal processing module；Described
Two position pulse wave inductive module farther include one second digital-to-analogue conversion module, for the second position
Locate the first pulse wave signal B1With second position the second pulse wave signal B2Be filtered, signal amplifies
And analog digital conversion, and the signal after conversion is transferred to signal processing module.
Described first transmission signal difference Δ tAWith the second transmission signal difference Δ tBBetween poor Δ t and mean blood pressure
Relation between MBP is:
Wherein, k and c is two calibration parameters.
A kind of method utilizing blood pressure real-time measurement apparatus as above to measure blood pressure, including following step
Rapid:
S1, obtains the first pulse wave signal A of human body first position1And the second pulse wave signal A2；
S2, obtains the first pulse wave signal B of human body second position1And the second pulse wave signal B2；
S3, calculates the first pulse wave signal A1With the second pulse wave signal A2Between transmission time difference
ΔtA；
S4, calculates the first pulse wave signal B1With the second pulse wave signal B2Between transmission time difference
ΔtB；
S5, obtains transmission time difference Δ tAWith transmission time difference Δ tBBetween poor Δ t；And
S6, according to this transmission time difference Δ tAWith transmission time difference Δ tBBetween poor Δ t calculate mean blood pressure
Value.
Compared with prior art, the blood pressure real-time measurement apparatus of present invention offer and measuring method, by adopting
The pulse wave phase information of collection two positions of human body calculates mean blood pressure, has the advantages that
Two pulse wave phase informations are extracted from two different positions, and average according to its mathematic interpolation
Blood pressure, eliminates the interference that measurement is brought by a certain position sensor minor variations, and operation simplifies a lot；
It addition, the position that pulse wave gathers is without fixing, can select reasonably according to the concrete condition of tested person
Collection point.
Accompanying drawing explanation
The functional block diagram of the blood pressure real-time measurement apparatus that Fig. 1 provides for the embodiment of the present invention.
Fig. 2 obtains the functional block of two-way pulse wave device for the first position that the embodiment of the present invention provides
Figure.
Fig. 3 obtains the functional block of two-way pulse wave device for the second position that the embodiment of the present invention provides
Figure.
The flow chart of the method measuring blood pressure in real time that Fig. 4 provides for the embodiment of the present invention.
The waveform of the different pulse waves that the human body primary importance measurement that Fig. 5 embodiment of the present invention provides obtains
And phase contrast.
The waveform of the different pulse waves that the human body second position measurement that Fig. 6 embodiment of the present invention provides obtains
And phase contrast.
Main element symbol description
Blood pressure real-time measurement apparatus 10
First position pulse wave inductive module 12
Second position pulse wave inductive module 14
Signal processing module 16
First position the first pulse wave induction module 122
First position the second pulse wave induction module 124
First analog-to-digital conversion module 126
Second position the first pulse wave induction module 142
Second position the second pulse wave induction module 144
Second analog-to-digital conversion module 146
Following detailed description of the invention will further illustrate the present invention in conjunction with above-mentioned accompanying drawing.
Detailed description of the invention
The blood pressure real-time measurement apparatus that the embodiment of the present invention provides is described in detail below with reference to accompanying drawing.
Seeing also Fig. 1 to Fig. 3, the embodiment of the present invention provides a kind of blood pressure real-time measurement apparatus 10,
This blood pressure real-time measurement apparatus 10 includes first position pulse wave inductive module 12, second position arteries and veins
Ripple inductive module 14 of fighting and signal processing module 16.
Described first position pulse wave inductive module 12 and described second position pulse wave inductive module
14 is two identical modules, can be respectively arranged at the diverse location of human body, is used for obtaining human body not coordination
Put the pulse wave signal locating each cardiac cycle, such as first position and second position each week aroused in interest
The two-way pulse wave signal of phase.Described first position pulse wave inductive module 12 includes a primary importance
Locate first pulse wave induction module 122, first position the second pulse wave induction module 124 and
First analog-to-digital conversion module 126.Described second position pulse wave inductive module 14 includes a second position
Locate first pulse wave induction module 142, second position the second pulse wave induction module 144 and
Two analog-to-digital conversion modules 146.
The position of described pulse wave induction module needs tremulous pulse distance epidermis relatively near or rich in capillary tremulous pulse, easily
In detection, include but not limited at oar finger tips, tremulous pulse, at carotid artery, at ear-lobe or dorsal artery of foot
The positions such as place.Described first position pulse wave inductive module 12 and described second position pulse wave sense
The sensed position answering module 14 to arrange is different.The first position that present invention embodiment selects is left arm
At radial artery, second position is left arm finger tips.
Described first position the first pulse wave induction module 122 is for obtaining the people of each cardiac cycle
Body first position the first pulse wave signal A1, described second position the first pulse wave induction module 142
For obtaining second position the first pulse wave signal B of each cardiac cycle1；Described first position
Two pulse wave induction modules 124 are for obtaining first position second pulse wave signal of each cardiac cycle
A2, described second position the second pulse wave induction module 144 is for obtaining the second of each cardiac cycle
Position the second pulse wave signal B2.Described first position the first pulse wave induction module 122 and first
The pulse wave type of position the second pulse wave induction module 124 sensing is different, different types of to measure
Pulse wave；Same, second position the first pulse wave induction module 142 and second position the second arteries and veins
The type of the pulse wave of ripple induction module 144 of fighting sensing is the most different, to measure different types of pulse wave.
Described first position the first pulse wave signal A1With second position the first pulse wave signal B1It can be phase
With the pulse wave signal of type, described first position the second pulse wave signal A2With second position
Two pulse wave signal B2It can be the pulse wave signal of same type.
The type of described pulse wave can include pressure pulse wave, photoplethysmographic or blood flow rate pulse
Ripple.Correspondingly, described first position the first pulse wave induction module 122, second position the first arteries and veins
Fight ripple induction module 142 and first position the second pulse wave induction module 124, second position second
Pulse wave induction module 144 can be respectively pressure pulse wave induction module, photoplethysmographic sensing
One in module and blood flow rate pulse wave induction module, as long as ensureing first position the first pulse wave
It is mutual that induction module 122 and first position the second pulse wave induction module 124 choose pulse wave sensing type
The induction apparatus differed, described second position the first pulse wave induction module 142 and second position the
Two pulse wave induction modules 144 choose the pulse wave sensing mutually different induction apparatus of type.
Described pressure pulse wave induction module is for sensing the pressure pulse wave of each cardiac cycle.Described pressure
Power pulse wave induction module can be realized by pressure transducer.Described pressure transducer includes that piezoelectric membrane passes
At least one in sensor and silica-based piezoresistance sensor.Can turning to signal of described pressure transducer sensing
The chemical conversion signal of telecommunication is transferred to described first analog-to-digital conversion module 126 and the second analog-to-digital conversion module 146, and
It is converted into digital data transmission to signal processing module 16.
Described photoplethysmographic induction module is for sensing the photoelectricity volume pulsation of each cardiac cycle
Ripple.The light intensity cardiac cycle sense that described photoplethysmographic induction module can be received by photo-detector
Survey the volume change optical signal that change is obtained in pulsating nature of blood in the tremulous pulse of position through photodetection
Device is converted to the signal of telecommunication and obtains described photoplethysmographic.Described photoplethysmographic induction module can
Including photocell and photodetector.Described photocell can be light emitting diode.Described photodetection
Device can be transmission type photoelectric detector or reflection photo-electric detector, can be according to selected measurement position
Determine.Preferably, reflection photo-electric detector is used to detect the optical signal of reflection,arterial.Described light
The operating wavelength range of fulgurite and photodetector can be the infrared region of 600nm to 1000nm.
Preferably, the operating wavelength range of described photocell and photo-detector is 800nm to 960nm.
Described blood flow rate pulse wave induction module is for sensing the blood flow rate pulse of each cardiac cycle
Ripple.Described blood flow rate pulse wave induction module can be magnetic sensing blood Flow Velocity pulse wave induction module or
Other can measure the induction apparatus of blood flow rate pulse wave of each cardiac cycle.Preferably, described blood flow
Velocity pulse ripple induction module uses magnetic sensing blood Flow Velocity pulse wave induction module.Described magnetic sensing blood flow
Velocity pulse ripple induction module can include biasing magnetic sheet and Magnetic Sensor.Described biasing magnetic sheet is arranged at dynamic
Arteries and veins position, is used for producing bias magnetic field, and described Magnetic Sensor senses the blood flow rate of each cardiac cycle
Change causes the signal of sensing position changes of magnetic field.Described induced signal changes into the signal of telecommunication and is transferred to institute
State the first analog-to-digital conversion module 126 and the second analog-to-digital conversion module 146, and be converted into digital data transmission
To signal processing module 16.Described Magnetic Sensor can be giant magneto-resistance sensor, tunnel magneto-resistive sensor or
Hall magnetic sensor.
The pulse wave induction module of first position first described in first embodiment of the invention 122, second
Put place's the first pulse wave induction module 142 for pressure pulse wave induction module；Described first position second
Pulse wave induction module 124, second position the second pulse wave induction module 144 are photoelectricity volume pulsation
Ripple induction module.
The pulse wave induction module of first position first described in second embodiment of the invention 122, second
Put place's the first pulse wave induction module 142 for blood flow rate pulse wave induction module, described first position
Second pulse wave induction module 124, second position the second pulse wave induction module 144 are photoelectricity volume
Pulse wave induction module.
The pulse wave induction module of first position first described in third embodiment of the invention 122, second
Put place's the first pulse wave induction module 142 for pressure pulse wave induction module, described first position second
Pulse wave induction module 124, second position the second pulse wave induction module 144 are blood flow rate pulse
Ripple induction module.
Described first analog-to-digital conversion module the 126, second analog-to-digital conversion module 146 can farther include a filter
Ripple and signal amplification module, for advanced to the first pulse wave signal received and the second pulse wave signal
Row filtering and signal amplify, and carry out analog digital conversion the most again.Described filtering and signal amplification module can use
Filter circuit and signal amplifier realize.Further, described first analog-to-digital conversion module 126, second
Analog-to-digital conversion module 146 can be integrated in signal processing module 16.
Described signal processing module 16 receives described first position pulse wave inductive module 12 and second
Put four road pulse wave signal A of place's pulse wave inductive module 14 transmission1、A2、B1、B2, and can obtain
The described first pulse wave signal A that first position receives1With the second pulse wave signal A2Between first
Transmission time difference Δ tA, the described first pulse wave signal B of second position reception1With the second pulse wave letter
Number B2Between the second transmission time difference Δ tB, further according to first position and two differences of second position
The tremulous pulse mean blood pressure of the poor Δ t each cardiac cycle of acquisition of the transmission time difference of sensed position, wherein,
Δ t=| Δ tA-ΔtB|.Further, described first pulse wave signal A1With the second pulse wave signal A2Between
Transmission time difference Δ tAThe first pulse wave signal A can be passed through1With the second pulse wave signal A2Between phase place
Difference Δ PAObtain；It is similar to, described first pulse wave signal B1With the second pulse wave signal B2Between
Transmission time difference Δ tBThe first pulse wave signal B can be passed through1With the second pulse wave signal B2Between phase place
Difference Δ PBObtain.The then transmission time difference of first position and two different sensed positions of second position
Difference Δ t can be by phase difference P of first positionAPhase difference P with second positionBPoor PDD
Obtain, wherein, PDD=| Δ PA-ΔPB|。
Described signal processing module 16 is calculating from i.e. primary importance or the second position at same position
Phase difference P of two-way pulse wave signalA、ΔPBTime, the first wave peak dot of two kinds of pulse waves can be used,
As shown in Figure 5, Figure 6.
Described signal processing module 16 calculate neither with sensed position i.e. primary importance and the second position it
Between the poor Δ t of transmission time difference time, directly neither transmission time difference with sensed position is subtracted each other.
When the tremulous pulse mean blood pressure of described each cardiac cycle is transmitted from described different sensed position pulse waves
Between the poor inversely proportional relation of Δ t of difference, namely the poor PDD of the phase contrast from different sensed position pulse waves
Inversely proportional relation.
The poor Δ t of different sensed position pulse wave transmission time differences described in the embodiment of the present invention and average blood
The relation of pressure is:
Wherein, MBP is mean blood pressure.K and c is two calibration parameters, can be obtained by demarcating module.
Simultaneously as the corresponding relation between Δ t and PDD, the then phase place of different sensed position pulse waves
The poor PDD of difference meets with the relation of mean blood pressure:
Described signal processing module 16 can farther include a demarcating module, and this demarcating module is used for determining
Described calibration parameter k and c.This demarcating module can perform a calibrating procedure, and this calibrating procedure includes:
The blood pressure measuring method measurement standard utilizing standard shrinks pressure (PS) and standard diastolic pressure (PD)
To organizing normal data more；
And record phase difference P of the first position simultaneously recordedAPhase difference P with second positionB
Poor PDD；
By the contraction pressure (P of described calibration gainedS) and diastolic pressure (PD) calculating of application experience formula is averagely
Blood pressure, empirical equation is:
Mean blood pressure MBP calibrated and calculated gone out is fitted with the corresponding PDD recorded, and calculates parameter
K and c.
The blood pressure measuring method of described standard can be to utilize the mercurial sphygmomanometer of standard to measure to obtain.This mark
Determine process operation simple, convenient and the accuracy of blood pressure measurement can be improved.In the present embodiment, use 5
Group normal data.It is appreciated that described calibrating procedure is only specific embodiment, it is possible to existing by other
Some scaling methods obtain k and c.
Described blood pressure real-time measurement apparatus 10 can farther include a display module, to show survey in real time
The pressure value measured or pressure value curve.
Described blood pressure real-time measurement apparatus 10 can farther include a transport module, for the reality that will record
Time pressure value be transferred to an intelligent terminal with further research and application.
Described transport module can be preferably wireless transport module.The transmission that described wireless transport module uses
Mode can be at least one in Bluetooth transmission, infrared transmission and radio frequency transmission.Described intelligent terminal
Can be that a monitoring device measures, for monitoring in real time, the pressure value arrived.Additionally, described intelligent terminal also may be used
To receive described pulse wave transmission time difference by described transport module, and calculated by this intelligent terminal
The mean arterial blood pressure of each cardiac cycle.
As a example by described first position pulse wave inductive module 12, can be by described first position
One pulse wave induction module 122, first position the second pulse wave induction module 124 and the first modulus
Modular converter 126 is integrated on a printed circuit board.This printed circuit board is preferably flexible printed circuit
Plate, so that this blood pressure real-time measurement apparatus 10 can be a flexible apparatus.In like manner, described second
Putting place's pulse wave inductive module 14 also can be the most integrally disposed.
Described first position pulse wave inductive module 12 and second position pulse wave inductive module 14 can
Include a body respectively, by described first position the first pulse wave induction module 122, second position
First pulse wave induction module 142, first position the second pulse wave induction module 124, the second position
Locate the second pulse wave induction module 144 and first analog-to-digital conversion module the 126, second analog-to-digital conversion module
146 encapsulation are wherein.Preferably, described body can be easy to be fixed on described blood pressure real-time measurement apparatus 10
Artery position.Preferably, described body can be a Wearable structure.Additionally, described body can also
It is a SMD structure, for described body apparatus being attached at the skin surface position close to tremulous pulse.
Described signal processing module 16, transport module even display module can also be integrally disposed.Preferably
Ground, can be integrated into first position by described signal processing module 16, transport module even display module
At pulse wave inductive module 12 or at second position pulse wave inductive module 14.
Referring to Fig. 4, the embodiment of the present invention further provides for one and utilizes above-mentioned blood pressure real-time measurement apparatus
10 methods measuring blood pressure in real time, comprise the following steps:
S1, obtains the first pulse wave signal A of human body first position1And the second pulse wave signal A2；
S2, obtains the first pulse wave signal B of human body second position1And the second pulse wave signal B2；
S3, calculates the first pulse wave signal A1With the second pulse wave signal A2Between transmission time difference
ΔtA；
S4, calculates the first pulse wave signal B1With the second pulse wave signal B2Between transmission time difference
ΔtB；
S5, obtains transmission time difference Δ tAWith transmission time difference Δ tBBetween poor Δ t；
S6, according to this transmission time difference Δ tAWith transmission time difference Δ tBBetween poor Δ t calculate mean blood pressure
Value.
In the method, transmission time difference and phase contrast are corresponding relation, and phase contrast is to survey at same position
The time to peak interval of the two paths of signals measured, as transmission time difference.Obtaining of described transmission time difference
The corresponding relation taken between mode and blood pressure and transmission time difference is introduced the most, does not repeats them here.
Embodiment 1
Described blood pressure real-time measurement apparatus 10 includes first position pulse wave inductive module 12, second
Put place's pulse wave inductive module 14 and signal processing module 16 and wireless transport module (not shown).
Described first position pulse wave inductive module 12, signal processing module 16 and wireless transport module collection
Become be arranged at a flexible PCB and form a wrist strap, be arranged at wrist, measure wrist oar in real time
Arteriotony value.Described second position pulse wave induction module 14 is fixed with medical 3M adhesive tape
In middle fingertip.Wherein, described first position the first pulse wave induction module 122, second position
First pulse wave induction module 142 is pressure pulse wave induction module, first position the second pulse wave sense
Module 124, second position the second pulse wave induction module 144 is answered to sense mould for photoplethysmographic
Block.
Referring to Fig. 5, Fig. 5 is the pressure pulse wave signal that records of first position and photoelectricity volume pulsation
Ripple signal.Wherein, the phase between some cardiac cycle, first position pulse wave difference pulse wave
Potential difference Δ PAFor the time interval between above two pulse wave primary peak, it is thus achieved that the pulse wave transmission time
Difference Δ tA.After testing, Δ tAFor 33.75ms.
Referring to Fig. 6, Fig. 6 is the pressure pulse wave signal that records of second position and photoelectricity volume pulsation
Ripple signal.Phase place wherein, at some cardiac cycle, between the dissimilar pulse wave of second position
Difference Δ PBFor the time interval between above two pulse wave primary peak, obtain pulse wave transmission time difference
ΔtB.After testing, Δ tBFor-35.25ms.
Calibration parameter k=0.048, c=79.2277, the mean blood pressure calculating this cardiac cycle of acquisition is
89.31mmHg。
Embodiment 2
The basic phase of blood pressure real-time measurement apparatus of the blood pressure real-time measurement apparatus of this embodiment and embodiment 1
With, difference is, in the present embodiment, and described first position the first pulse wave induction module 122, the
Two position the first pulse wave induction modules 142 are blood flow rate pulse wave induction module, first position
Second pulse wave induction module 124, second position the second pulse wave induction module 144 are photoelectricity volume
Pulse wave induction module.
After testing, Δ tAFor 42.33ms, Δ tBFor 22.15ms, calibrate parameter k=0.0116, c=65.3333,
The mean blood pressure calculating this cardiac cycle of acquisition is 93.8183mmHg.
Embodiment 3
The basic phase of blood pressure real-time measurement apparatus of the blood pressure real-time measurement apparatus of this embodiment and embodiment 1
With, difference is, in the present embodiment, and described first position the first pulse wave induction module 122, the
Two position the first pulse wave induction modules 142 are blood flow rate pulse wave induction module, first position
Second pulse wave induction module 124, second position the second pulse wave induction module 144 are pressure pulse
Ripple induction module.
After testing, Δ tAFor 12.45ms, Δ tBFor 55.27ms, calibrate parameter k=0.0514, c=60.25,
The mean blood pressure calculating this cardiac cycle of acquisition is 88.2830mmHg.
The present invention calculates mean blood pressure, tool by gathering the pulse wave phase information of two positions of human body
There is following advantage: first, it is not necessary to gather electrocardiosignal and calculate PTT, it is not necessary to electrode Long contact time health,
Many electrical leads will not be produced；Secondly, the difference of pulse wave phase contrast namely the difference of transmission time difference are utilized
With the relation of blood pressure, sensor is convenient to be obtained, suitable sense invariably during somatometry；Furthermore, from two
Two pulse wave phase informations are extracted in individual different position, obtain pulse wave transmission time difference, and
According to its mathematic interpolation mean blood pressure, eliminate single position sensor minor variations to measuring bring dry
Disturbing, operation simplifies a lot；Finally, the position that pulse wave gathers, can be according to tested person's without fixing
Concrete condition selects rational collection point.
Change it addition, those skilled in the art can also do other in spirit of the present invention, certainly, these
The change done according to present invention spirit, within all should being included in scope of the present invention.
Claims (10)
1. a blood pressure real-time measurement apparatus, it is characterised in that including:
One first position pulse wave inductive module, including first position the first pulse wave induction module
And first position the second pulse wave induction module, to sense the different types of pulse wave of first position
Signal；
One second position pulse wave inductive module, including second position the first pulse wave induction module
And second position the second pulse wave induction module, to sense the different types of pulse wave of second position
Signal；And
One signal processing module, for the first arteries and veins to the sensing of first position the first pulse wave induction module
Fight ripple signal A1, first position the second pulse wave induction module sensing the second pulse wave signal A2,
First pulse wave signal B of two position the second pulse wave induction module sensings1And second position the second arteries and veins
Second pulse wave signal B of ripple induction module of fighting sensing2Process, and calculate the first pulse wave signal
A1With the second pulse wave signal A2Between first transmission signal difference Δ tA, and the first pulse wave signal B1
With the second pulse wave signal B2Between second transmission signal difference Δ tB, simultaneously according to the first transmission signal difference
ΔtAWith the second transmission signal difference Δ tBBetween poor Δ t, it is thus achieved that the tremulous pulse mean blood pressure of each cardiac cycle
MBP。
2. blood pressure real-time measurement apparatus as claimed in claim 1, it is characterised in that first position pulse wave sense
Answering module is two identical modules with described second position pulse wave inductive module, is respectively arranged at not
Same sensed position, to obtain the pulse wave signal of each cardiac cycle of various location.
3. blood pressure real-time measurement apparatus as claimed in claim 1, it is characterised in that described different types of pulse
Ripple signal is selected from pressure pulse wave, photoplethysmographic or blood flow rate pulse wave.
4. blood pressure real-time measurement apparatus as claimed in claim 3, it is characterised in that described first position first
Pulse wave signal A1With second position the first pulse wave signal B1For the pulse wave signal of same type,
Described first position the second pulse wave signal A2With second position the second pulse wave signal B2For identical
The pulse wave signal of type.
5. blood pressure real-time measurement apparatus as claimed in claim 3, it is characterised in that described first position pulse
Ripple inductive module farther includes one first D/A converter module, for first position the first pulse wave
Signal A1With first position the second pulse wave signal A2Be filtered, signal amplifies and analog digital conversion,
And the signal after conversion is transferred to signal processing module；Described second position pulse wave inductive module is entered
One step includes one second digital-to-analogue conversion module, for second position the first pulse wave signal B1With second
Position the second pulse wave signal B2Be filtered, signal amplifies and analog digital conversion, and by the letter after conversion
Number it is transferred to signal processing module.
6. blood pressure real-time measurement apparatus as claimed in claim 1, it is characterised in that described first transmission signal difference
ΔtAWith the second transmission signal difference Δ tBBetween poor Δ t and mean blood pressure MBP between relation be:
Wherein, k and c is two calibration parameters.
7. blood pressure real-time measurement apparatus as claimed in claim 6, it is characterised in that described signal processing module enters
One step includes a demarcating module, and this demarcating module is used for determining described calibration parameter k and c, this calibration mold
Block includes calibrating procedure, and this calibration process is:
The blood pressure measuring method measurement standard utilizing standard shrinks pressure PSWith standard diastolic pressure PDObtain many groups
Normal data；
And record phase difference P of the first position simultaneously recordedAPhase difference P with second positionB
Poor PDD；
P is pressed in the contraction of described calibration gainedSWith diastolic pressure PDApplication experience formula calculates mean blood pressure, warp
Testing formula is:
Mean blood pressure MBP calibrated and calculated gone out is fitted with the corresponding PDD recorded, and calculates parameter
K and c.
8. utilize the method that the blood pressure real-time measurement apparatus described in claim 1-7 any one measures blood pressure,
Comprise the following steps:
S1, obtains the first pulse wave signal A of human body first position1And the second pulse wave signal A2；
S2, obtains the first pulse wave signal B of human body second position1And the second pulse wave signal B2；
S3, calculates the first pulse wave signal A1With the second pulse wave signal A2Between transmission time difference
ΔtA；
S4, calculates the first pulse wave signal B1With the second pulse wave signal B2Between transmission time difference
ΔtB；
S5, obtains transmission time difference Δ tAWith transmission time difference Δ tBBetween poor Δ t；And
S6, according to this transmission time difference Δ tAWith transmission time difference Δ tBBetween poor Δ t calculate mean blood pressure
Value.
9. the method measuring blood pressure as claimed in claim 8, it is characterised in that described first position pulse wave
Inductive module is arranged at wrist, is used for measuring wrist radial artery pressure value；Described second position pulse
Ripple inductive module is arranged at finger tip.
10. the method measuring blood pressure as claimed in claim 8, it is characterised in that described first pulse wave signal
A1With the second pulse wave signal A2Between transmission time difference Δ tABy the first pulse wave signal A1With
Two pulse wave signal A2Between phase difference PAObtain；Described first pulse wave signal B1With the second arteries and veins
Fight ripple signal B2Between transmission time difference Δ tBBy the first pulse wave signal B1With the second pulse wave letter
Number B2Between phase difference PBObtain；First position and two different sensed positions of second position
The poor Δ t of transmission time difference phase difference P by first positionAPhase difference P with second positionB
Poor PDD obtain, wherein, PDD=| Δ PA-ΔPB|。
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