CN105848625B - Beverage cartridge comprising pharmaceutically active substance - Google Patents
Beverage cartridge comprising pharmaceutically active substance Download PDFInfo
- Publication number
- CN105848625B CN105848625B CN201480064906.8A CN201480064906A CN105848625B CN 105848625 B CN105848625 B CN 105848625B CN 201480064906 A CN201480064906 A CN 201480064906A CN 105848625 B CN105848625 B CN 105848625B
- Authority
- CN
- China
- Prior art keywords
- cylinder
- childproof
- another example
- children
- capping
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000013543 active substance Substances 0.000 title claims abstract description 25
- 235000013361 beverage Nutrition 0.000 title description 43
- 238000012360 testing method Methods 0.000 claims abstract description 46
- 238000012216 screening Methods 0.000 claims abstract description 19
- 230000035515 penetration Effects 0.000 claims description 15
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 11
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 10
- 229960005489 paracetamol Drugs 0.000 claims description 10
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 229960000520 diphenhydramine Drugs 0.000 claims description 7
- 239000011888 foil Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 229920000092 linear low density polyethylene Polymers 0.000 claims description 6
- 239000004707 linear low-density polyethylene Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 229920001684 low density polyethylene Polymers 0.000 claims description 4
- 239000004702 low-density polyethylene Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000003351 stiffener Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 28
- 239000010410 layer Substances 0.000 description 100
- 239000011149 active material Substances 0.000 description 41
- 238000004806 packaging method and process Methods 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 230000009467 reduction Effects 0.000 description 13
- 239000000853 adhesive Substances 0.000 description 10
- 230000001070 adhesive effect Effects 0.000 description 10
- 230000004888 barrier function Effects 0.000 description 10
- -1 polytrifluorochloroethylene Polymers 0.000 description 10
- 230000003014 reinforcing effect Effects 0.000 description 9
- 206010022000 influenza Diseases 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 229920000728 polyester Polymers 0.000 description 6
- 241001122767 Theaceae Species 0.000 description 5
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 5
- 230000007613 environmental effect Effects 0.000 description 5
- 235000013355 food flavoring agent Nutrition 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- 239000005030 aluminium foil Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- IKZZIQXKLWDPCD-UHFFFAOYSA-N but-1-en-2-ol Chemical compound CCC(O)=C IKZZIQXKLWDPCD-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229940126534 drug product Drugs 0.000 description 4
- 229920001903 high density polyethylene Polymers 0.000 description 4
- 239000004700 high-density polyethylene Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 3
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 3
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 229960001985 dextromethorphan Drugs 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229920008790 Amorphous Polyethylene terephthalate Polymers 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- KBAUFVUYFNWQFM-UHFFFAOYSA-N Doxylamine succinate Chemical compound OC(=O)CCC(O)=O.C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 KBAUFVUYFNWQFM-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 235000020965 cold beverage Nutrition 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 229960005008 doxylamine succinate Drugs 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000003862 health status Effects 0.000 description 2
- 235000012171 hot beverage Nutrition 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 229940105623 neo-synephrine Drugs 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000003813 thumb Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 238000009941 weaving Methods 0.000 description 2
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
- 239000004821 Contact adhesive Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 229920010126 Linear Low Density Polyethylene (LLDPE) Polymers 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920006687 PET, APET Polymers 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000008921 facial expression Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 230000035929 gnawing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229960003088 loratadine Drugs 0.000 description 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002365 multiple layer Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 1
- 229960003908 pseudoephedrine Drugs 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000009517 secondary packaging Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000007725 thermal activation Methods 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 229940117958 vinyl acetate Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
- B65D85/70—Containers, packaging elements or packages, specially adapted for particular articles or materials for materials not otherwise provided for
- B65D85/804—Disposable containers or packages with contents which are mixed, infused or dissolved in situ, i.e. without having been previously removed from the package
- B65D85/8043—Packages adapted to allow liquid to pass through the contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1406—Septums, pierceable membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2027—Separating means having frangible parts
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Packages (AREA)
- Apparatus For Making Beverages (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Laminated Bodies (AREA)
Abstract
The invention discloses a kind of suitable for the cylinder for the Childproof being used together with automatic brewing apparatus.Cylinder has base portion and capping.Base portion may include pharmaceutically active substance.Capping can be the multilayer laminate with outer layer and internal layer.Cylinder can be by being enough to prevent 70% children to be made during Childproof screening test close to the tear-resistant material of the content of three or more.
Description
Technical field
The present invention relates to a kind of beverage cartridges, and more specifically, a kind of beverage suitable for preparing comprising pharmaceutically active substance
Cylinder.
Background technique
Currently, there are a variety of cylinders used in the automatic brewing apparatus of preparation one cup beverage products such as coffee or tea.So
And current cylinder is not suitable for being used together with pharmaceutically active substance, because active material is to environmental condition such as humidity and oxygen
Sensitivity, and active material is degraded in current cylinder.In addition, Consumer Product Safety Commission (CPSC) requires, if cylinder includes
Certain active constituents such as paracetamol and diphenhydramine, then primary package is Childproof.
Be suitable for the cylinder used in automatic brewing apparatus therefore, there is still a need for a kind of, this tin be both Childproof and
For the barrier with environmental condition, to provide the long-time stability of pharmaceutically active substance.
Summary of the invention
A kind of cylinder for the Childproof being adapted to fit in automatic brewing apparatus, comprising: (a) base portion, wherein base portion include
Pharmaceutically active substance;(b) it covers, wherein capping includes multilayer laminate, which includes outer layer and internal layer;Wherein
Cylinder is by being enough to prevent 70% children close to the resistance to of the content of five or more cylinders during Childproof screening test
Tearing material is made.
A kind of multilayer laminate capping of the Childproof suitable for cylinder, comprising: (a) outer layer;(b) internal layer;Wherein
Capping is by being enough to prevent 70% children from covering by piercing through close to five or more during Childproof screening test
The tear-resistant material of the content of cylinder is made and wherein covers and can be penetrated by the syringe needle of automatic brewing apparatus or other penetration devices.
A kind of cylinder for the Childproof being adapted to fit in automatic brewing apparatus, comprising: (a) base portion, wherein base portion include
Pharmaceutically active substance;(b) it covers;Wherein cylinder prevents 70% children from approaching by being enough during Childproof screening test
The tear-resistant material of the content of five or more cylinders is made.
Detailed description of the invention
Fig. 1 is the three-dimensional, exploded view of beverage cartridge;
Fig. 2 is the side sectional view of the beverage cartridge of Fig. 1;
Fig. 3 is the side sectional view of the capping for beverage cartridge;
Fig. 4 A is the capping for beverage cartridge;
Fig. 4 B is the capping for beverage cartridge;
Fig. 5 is that there are two the side sectional views of the beverage cartridge of compartment for tool;
Fig. 6 is the example of the side sectional view of the beverage cartridge with two chambers;And
Fig. 7 is the exemplary three dimensional exploded view of the beverage cartridge with filter.
Specific embodiment
Many consumers like drinking hot drink or cold drink with pharmaceutically active substance.Prepare one cup hot drink or cold drink just
Sharp and easy way is using the automatic brewing apparatus with cylinder.However, current cylinder is unsuitable for due to two and medicine
Active substances are used together.Firstly, current cylinder does not provide enough barriers to environmental condition to prevent from degrading.Secondly, working as
Preceding cylinder is not Childproof.It has been observed that children can open in the following manner current cylinder: utilizing theirs
Tooth and then using their finger peel off capping with approach content or by using they thumb to capping apply
Pressure covers to pierce through.As soon as once he can quickly open other cylinder in addition, children have understood how to open a cylinder.
Cylinder of the invention can provide and enough barriers of environmental condition and can be for Childproof, the environmental condition
Including humidity and gas, including oxygen.The structure and/or material of bottom and/or capping can provide the long-term of pharmaceutically active substance
Stability and/or Childproof.Cylinder can have base portion and closure construction.In one example, base portion can be multiple-layer laminated
Body may include polytrifluorochloroethylene (PCTFE), adhesive and the polyethylene terephthalate with glycol modification agent
(PETG).In another example, capping can be multilayer laminate structure, may include aluminium foil, adhesive and plastics.Base
Portion and/or capping can be tear-resistant.Although the bottom of base portion and/or capping still may be used in addition, being Childproof
To be that can be penetrated by the syringe needle of automatic brewing apparatus or penetration device.
This tin can meet the Childproof according to U.S.'s gas defence packaging bill (16C.F.R. § 1700.14) in 1970
Restriction.Specifically, cylinder can meet the restriction of the F=3 according to Childproof as described herein test.In another example
In, cylinder can meet according to Childproof test F=1, in another example F=2, in another example F=4,
F=5 and the restriction of F=6 in another example in another example.In one example, in the feelings of not secondary package
Under condition, only cylinder itself meets the restriction of Childproof.
Cylinder is applicable to automaton, the automatic brewing apparatus of such as one cup.Some in these machines have penetration device or
Syringe needle, the penetration device or syringe needle, which can penetrate, to be covered and then provides the stream of the water (usually hot water) by the hole in capping
It is dynamic, while the second penetration device or syringe needle squeeze through the bottom of base portion to receive the outflow of beverage and assign it to cup or container
In.Although base portion and capping layer are Childproofs, in some instances, they can be by the penetration device or needle of brewing apparatus
Head penetrates.In another example, Childproof and/or barrier characteristics do not interfere the normal operating of automatic brewing apparatus.
As used herein, " active material " or " pharmaceutically active substance " includes that can be used in mammal especially people
The whole compounds and composition for the treatment of and/or prevention disease and/or offer general health and healthy and beneficial effect.Specifically have
The non-limiting example of active material includes the work of active material and prescription after over the counter (OTC) active material, sales counter
Property substance, vitamin, minerals, the substance of plant origin, energy excitation substance, probiotics, fiber, prebiotics and they
Combination.
As used herein, " Childproof " refer to be designed or be configured to make child open within reasonable time or
Obtain the substance addition difficult wherein included of toxic or harmful amount, and cylinder not difficult for proper use of adult or
Other packagings, but not refer to that all such children cannot open or obtain within reasonable time the packet of toxic or harmful amount
Dress.
As used herein, " dissolution ", which refers to, gradually becomes solution.
As used herein, " decomposition ", which refers to, is broken into fraction.
As used herein, " permanently engage " refers to that wherein first element is fixed to second element, so that not at least
These elements usually can not configuration separated from each other in the case where partly destroying one or both of these elements.
As used herein, " primary package " refer to or the package member that can directly be contacted with dosage form.
As used herein, it " is releasably engaged " and refers to that wherein first element is fixed to second element, so that first element
With second element can be separated in the case where not damaging or minimally damaging first element and second element configuration.
As used herein, " tear-resistant " be refer to experience reasonable level stress and/or deformation and do not suffer from integrality
Significant loss.Stress and/or deformation can be applied by multi-motion, including but not limited to bite, pull at cylinder, shelling, stabbing,
It pushes away and/or discloses.In one example, any of these movements can be carried out by children, and tear-resistant be referred to be subjected to can
When the power applied by children, material can undergo reasonable level stress and/or deformation and do not suffer from the significant loss of integrality.
In one example, children are six years old or smaller, in another example five years old or smaller, in another example four years old or more
It is small, three years old or smaller in another example, two years old or smaller in another example, and 18 months in another example
Or it is smaller.In one example, although cylinder be it is tear-resistant, still can be used automatic brewing apparatus syringe needle or penetration device by it
It pierces through.
As used herein, term " processing " (treat or treating) includes prevention, alleviates, improves, inhibits or mitigate
One or more health status of mammal (especially people and such as adult).The non-limiting example of health status can
Including respiratory passage diseases.
As used herein, "one" and "an" of article be understood to claimed or description one kind or
Multiple material, for example, " a kind of active material " or " compartment ".
Fig. 1 shows the exploded view of cylinder 1 and Fig. 2 shows the side sectional views of cylinder 1.Cylinder 1 includes base portion 10 and capping 20.Base
Portion 10 includes the edge 13 of opening 11 and facing external.Base portion 10 can have cup, cylinder, bowl or inverted truncated cone
Shape.Base portion 10 may include component 12, and component 12 may include active material and/or excipient.In one example, the component
It can be powder.The bottom 15 of base portion 10 can be pierced device during use or syringe needle penetrates.
With reference to Fig. 2, the edge 13 of base portion 10 can be permanently joined at sealing 25 by covering 20 inner surface 26.Envelope
Lid can be bonded to base portion by any suitable method.In one example, capping have thermal activation coating, thus make its
The edge of base portion is attached to when being exposed to heat.In another example, it covers and supersonic frequency attachment can be used, and at another
In example, covers and induction heating attachment can be used.Alternatively, capping can be attached with contact adhesive.
Capping 20 can be the lamilate of the Childproof with outer layer 21 and internal layer 22.Outer layer 21 can provide child-resistant and open
Opening property and can be to be tear-resistant, while still can be penetrated by the syringe needle of automatic brewing apparatus or other penetration devices.In an example
In, outer layer 21 may include reinforcing lines 24, can provide other Childproof.Reinforcing lines 24 can be in entire capping 20
Upper formation mesh sheet, and in one example, at the position that capping is intended to be pierced through by syringe needle or penetration device, mesh sheet can be opening
's.In one example, it reinforces in the lamilate of the embeddable Childproof of lines.In another example, lines are reinforced to exist
Below outer layer.In another example, reinforcing lines can be below internal layer.In another example, reinforcing lines can be in outer layer
Between internal layer.In another example, it reinforces in the embeddable outer layer of lines and/or internal layer.Reinforcing lines can be by any suitable
Material be made, including nylon, polypropylene, glass fibre and their combination.
Internal layer 22 can reduce the amount into the gas (including oxygen) of cylinder 1.Internal layer 22 can be made of any suitable material,
And in one example, internal layer 22 can be made of aluminium foil.Internal layer 22 can be to be opaque, this can provide other child-resistant and opens
Qi Xing.In another example, internal layer 22 may also include ink.In one example, outer layer 21 and internal layer 22 pass through adhesive forever
Engage to long property.
Capping may be either Childproof, and can provide enough barriers with gas and humidity, while still can be by certainly
The syringe needle or other penetration devices of dynamic brewing apparatus penetrate.In one example, it covers as lamilate.Lamilate can have any number
Layer.In one example, lamilate is at least two layers, in another example at least three layers, in another example
In at least four layers, and at least five layers in another example.In another example, capping can be only one layer.?
In one example, one or more layers of capping can be opaque, and in another example, the one or more of capping
Layer can be transparent.
Fig. 3 is the example of the side sectional view of the capping 30 for beverage cartridge.Capping 30 may include outer layer 32, the second layer
33, third layer 34 and internal layer 35.In one example, outer layer 32 may include polyethylene terephthalate (PET), second
Layer 33 may include oriented polyamide (OPA), and third layer 34 may include aluminium, and internal layer 35 may include polyethylene vinylacetate
(PE-EVA).In another example, internal layer 35 may include linear low density polyethylene (LLDPE).In one example, each
Layer is attached to adjacent layer using adhesive.In another example, ink is between outer layer and the second layer.In another example
In, ink print is on outer layer.In another example, heat seal coating partly or completely all standing internal layer.
Fig. 4 A and 4B are the examples with the capping of atenuator region.The region of reduction can be at being intended to by automatic brewing apparatus
In the region that syringe needle or other penetration devices pierce through.It is Childproof that the region of this reduction, which allows capping, while still
Allow to cover and be penetrated by syringe needle or penetration device.The region of reduction can partially or completely extend through one or more of lamilate capping
A layer.In one example, the region of reduction is on the outer layer of capping.In another example, the region of reduction is not at
On the outer layer of capping, because children may can be appreciated that the region of reduction and be approached or picked up at the edges of regions of reduction
And it removes.In one example, the region of reduction does not penetrate internal layer.In another example, the region of reduction only penetrates or portion
Divide and penetrates outer layer.In one example, the region of reduction can be to be sufficiently small, so that children are difficult with its content close to cylinder
Object.In one example, the region of reduction is about 1mm to about 12mm at its widest point, be in another example about 2mm extremely
About 10mm, and be in another example about 3mm to about 8mm.
Fig. 4 A is the region with reduction, the i.e. example of the capping 40 in hole 42.The hole can be any suitable shape.Shape
Non-limiting example may include circle, square, diamond shape, rectangle, triangle, star, cross, ellipse and they
Combination.
Fig. 4 B is the region with reduction, the i.e. example of the capping 45 of knurled portion 47.Knurled portion 47 can be for above-listed
Any of shape out, and " x ", intersecting hachure, Duo Gedian and their combination.
Fig. 5 is the example of the side sectional view of the beverage cartridge 5 with more than one compartment.It, will be some for some components
It can be advantageous that ingredient, which separates until they will be consumed,.In one example, active material and/or excipient are not
Stability compatible and that they are separately extended to these components.In another example, the component is in different conditions,
Such as a kind of group be divided into solid and another group is divided into liquid.In another example, a compartment includes active object
The component of matter and another compartment include the component with flavoring agent, this allows more steady flavor delivery, especially
When flavoring agent is liquid.
In Fig. 5, beverage cartridge 5 have the first compartment 51 comprising the first component 53 and second comprising the second component 54 every
Room 52.First compartment 51 and second compartment 52 are separated by separator 55.
Separator can be any suitable material.In one example, when being exposed to hot water or cold water, separation sections
Or it is completely dissolved or partially or completely decomposes.In another example, separator can be when group is divided into solid by component point
The mesh material or weaving material opened, but when component is dissolved in water, solution may pass through mesh material or weaving material.Another
In one example, syringe needle or penetration device puncture separator from automatic brewing apparatus can be used.When separator is pierced, water and
Two components can flow to first compartment from second compartment.
Beverage cartridge can have multiple compartments.In one example, beverage cartridge can have at least two compartments, show at another
At least three compartments in example, and at least four compartment in another example.Compartment can extend in any direction, including water
It is flat across cylinder, from base bottom vertically to capping, diagonally or their combination.
Fig. 6 is the example of the side sectional view of the beverage cartridge 6 with multiple chambers.Cylinder 6, which has, includes the first component 63
First chamber 61 and second chamber 62 comprising the second component 64.Chamber can not only keep component to separate until that will use it
Before, and they allow which kind of active material user's selection wants in its beverage.
In one example, automatic brewing apparatus can have a top syringe needle 66, approximate to pierce through capping 65 and not at center
Pierce through first chamber 61 or second chamber 62.Meanwhile lower needle 67 pierces through bottom 68 and the chamber 63 of base portion 69.Lower needle
67 do not pierce through the centre of base portion 67, its opposite eccentric puncture.Therefore, there is specific orientation in brewing apparatus by arrangement cylinder 6,
One chamber can be destroyed, while another chamber keeps complete.In one example, chamber can be made simultaneously of friable material
And/or person can preparatory indentation, so as to when lower needle pierce through chamber when, chamber cracks or fractures into two or more portions completely
Point.The non-limiting example of friable material may include starch basement membrane, water-soluble modified cellulose membrane such as hydroxyethyl cellulose, second
Base vinylacetate film and their combination.When brewed beginning, water will flow out top syringe needle and around complete chamber
Flowing, while being mixed with the component of rupture chamber and preparing the beverage with desired component.
For example, first chamber may include the active material to treat pain, such as paracetamol or brufen, and
And second chamber may include the active material for treating cough, such as dextromethorphan.If consumer does not cough, she
Cylinder can be located in automatic brewing apparatus, so that only penetrating the chamber with the active material for pain by bottom syringe needle.
However, if consumer want two kinds of active materials, she can it is brewed twice, pierce through two chambers.
In another example, chamber may include different flavoring agent, so that user be allowed to select the taste of its beverage.
In another example, top syringe needle can pierce two chambers.Lower needle only pierces through a chamber and comes from
The liquid of top syringe needle is flowable into two chambers, but beverage will only be able to flow from the chamber pierced through by lower needle
Out.Therefore, consumer can prepare the beverage with desired component.
Cylinder can have any suitable number of chamber.In one example, cylinder can have at least two chambers, at another
At least three chamber in example, and at least four chamber in another example.In one example, cylinder can have single chamber
Room, allowing consumer's preparation, only there are two types of the beverages of component for the beverage of the component with exterior thereto or preparation tool.
In another example, chamber can be used for separately incompatible component.
Fig. 7 is the example of the cylinder 7 with base portion 70, capping 71 and filter 72.Filter 72 includes component 73.When
Filter can be used in infusion beverage such as coffee or tea time.For water by the essence of percolating filter and extraction components, solid particle will
It keeps in the filter.In one example, when water passes through filter, active material and/or other excipient be can dissolve
In water.In one example, the brewed coffee or tea comprising active material of cylinder with filter can be used.
In one example, cylinder does not include filter.
In another example, at least one is component packaged prepares in autonomous container and by consumer or for consumer
The people of beverage adds before or after through automatic brewing apparatus beverage brewed.In one example, which can be flavoring agent,
And in another example, which may include one or more active materials.In one example, autonomous container can be small
Bag.In one example, autonomous container may include liquid.In another example, autonomous container may include solid, wherein solid
It can be powder, sugared grain, capsule, tablet or their combination.In another example, consumer is pierced using automatic brewing system
Wear the top of cylinder, but before beverage brewed, consumer reopen machine and the hole that is prepared by automatic brewing apparatus to
The ingredient of independent packaging is added in cylinder, and machine is then re-closing off simultaneously beverage brewed.
Base portion can be made of any suitable material, the material provide desired barrier property and Childproof and
It can still be penetrated by the syringe needle of automatic brewing apparatus or penetration device.The non-limiting of the material that can be coupled in the laminate of base portion is shown
Example may include high density polyethylene (HDPE) (HDPE), cyclic olefin copolymer (COC), Biaxially orientated polyamide (OPA), polypropylene
(PP), polyester (PET), amorphous polyethylene terephthalate (APET), polyvinyl chloride (PVC), polyethylene (PE), aluminium foil,
And their combination.In another example, lamilate may include gathering inclined vinylidene chloride coating, and show at another
In example, lamilate may include ethyl vinyl alcohol (EVOH).In one example, base portion can be transparent, in another example,
Base portion can be opaque.
In one example, base portion can be for by polytrifluorochloroethylene (PCTFE), optional adhesive and glycol modification
Polyethylene terephthalate (PETG) made of lamilate.In one example, PETG can be about 25 μm to about 1.5mm
Thickness is about 50 μm in another example to about 1mm, is in another example about 100 μm to about 500 μm, and another
It is about 200 μm to about 300 μm in a example.In another example, PCTFE can be about 10 μm to about 250 μm, show at another
It is about 25 μm to about 150 μm in example, is in another example about 30 μm to about 100 μm, and be in another example about
40 μm to about 75 μm.
In one example, base portion can be the lamilate with internal layer and outer layer.In one example, internal layer can be
EVOH or children are difficult to another material for piercing through or tearing.The internal layer and outer layer of base portion can be releasably engaged.Work as children
It when attempting to open container, such as by puncture, tearing or bites, internal layer can be separated with outer layer.It is this separately children to be made to subtract
Slowly, this can give parent or tender more times to interfere and prevent children close to cylinder.It is this separately also children to be made to feel
Feel that they achieve progress on opening packaging, and the two layer of layering in fact do not help to obtain the close of component,
Because children cannot break internal layer and/or outer layer.
In one example, the maximum gauge of base material can be greater than current pharmaceutical product barrier material (such as blister card
On chamber) maximum gauge because cylinder have greater than typical pharmaceutical product shell size.When forming the base portion of cylinder, make
Sufficient thickness is provided with the base material with bigger initial thickness, because the bottom of the material towards cylinder base portion is stretched
Bigger degree.
Current capping can be removed by children using the combination for biting and plugging.Therefore, capping can be tear-resistant.?
In one example, cover as multilayer laminate.The non-limiting example for the material that can be coupled in the laminate of capping can wrap
Include aluminium foil, PCTFE, EVOH, HDPE, OPA, COC, PP, PET, APET, PVC, PE and their combination.
For the lamilate and both base portions in capping layer, the layer of lamilate can be attached by adhesive phase, adhesive phase
It may include polyolefine material, such as low density polyethylene (LDPE) (LDPE).
In one example, lamilate can have outer layer, the second layer and internal layer.Outer layer can be PET, and the second layer can be
Foil, and internal layer can be LLDPE.
In one example, outer layer or pet layer can be about 5 μm to about 40 μ m-thicks, be in another example about 10 μm extremely
About 35 μ m-thicks are about 15 μm in another example to about 30 μ m-thicks, and are in another example about 20 μm to about 25 μm
It is thick.In another example, outer layer or pet layer can be greater than about 8 μm, greater than about 11 μm in another example, show at another
Greater than about 16 μm in example, greater than about 20 μm in another example, and it is greater than about 22 μm in another example.
In another example, the second layer or layers of foil can be about 3 μm to about 30 μm, be in another example about 8 μm extremely
About 25 μ m-thicks, and be in another example about 15 μm to about 22 μ m-thicks.In another example, the second layer or layers of foil can be big
In about 5 μ m-thicks, greater than about 8 μ m-thicks in another example, greater than about 12 μ m-thicks in another example, in another example
Greater than about 15 μ m-thicks, and it is greater than about 17 μ m-thicks in another example.
In another example, internal layer or LLDPE layers can be about 10 μm to about 40 μ m-thicks, in another example be about 15
It is in another example about 20 μm to about 30 μ m-thicks, and be in another example about 22 μm to about μm to about 35 μ m-thicks
27 μ m-thicks.In another example, internal layer or LLDPE layers can be greater than about 8 μ m-thicks, in another example greater than about 13 μ m-thicks,
It is greater than about 18 μ m-thicks in another example, in another example greater than about 20 μ m-thicks, in another example greater than about 22 μ
M is thick, and is greater than about 24 μ m-thicks in another example.
Base portion, capping, and/or cylinder can provide effective barrier.In one example, base portion, capping, and/or cylinder
The final moisture transmission that can have is about 2 × 10-5To about 2 × 10-3G//day, be about 1 × 10 in another example-4Extremely
About 6 × 10-4G//day, and be in another example about 2 × 10-4To about 3 × 10-4G//day, such as pass through United
States Pharmacopeial (USP)<671>(on August 1st, 2013) is measured.It follows for Single-Unit
The method 1 of the program of Containers and Unit-Dose Containers for Capsules and Tablets.
Cylinder can provide long-time stability for pharmaceutically active substance.In one example, the pharmaceutically active substance in cylinder has
Shelf life be at least about 1 year, at least about 18 months in another example, at least about 2 years in another example, and
At least about 2.5 years in another example.As used herein, " shelf life " refers to a period of time, the drug in this period
Product is estimated to be maintained within the shelf life of approval, and precursor conditions are that it is stored up under conditions of limiting in containers labels
It deposits.The locating condition of building shelf life test, specific measurement and it is available, suitable for consuming or minimum essential requirement for sale
It can disclose by government or set by regulatory authorities and in directive document, such as United States
Pharmacopeial (USP) or ICH Harmonised Tripartite Guideline Stability Testing of
New Drug Substances and Products Q1A (R2), step 4, on 2 6th, 2003 announcement versions.
In one example, pharmaceutically active substance is at least about the 90% of label, continues at least 1 year, shows at another
At least about 1.5 years in example, at least about 2 years in another example, and at least about 3 years in another example.At another
In example, pharmaceutically active substance is at least about the 95% of label, continues at least 1 year or at least about 1.5 years or at least about 2
Year.Cylinder can by keep pharmaceutically active substance be greater than about 80% or label continue at least about 1 year or at least about 1.5 years or
At least long-time stability are provided over 2 years.
Cylinder can be in secondary package.In one example, secondary package can be standard cardboard case, it includes about 1 to
About 12 cylinders, and about 3 to about 6 cylinders in another example.In another example, secondary package can be Childproof
's.In one example, secondary package can be conducive to the overall Childproof of cylinder.In another example, secondary package
It can be packed for F=1 Childproof, F=2 Childproof is packed in another example, and F=in another example
3 Childproofs packaging.In another example, each cylinder is individually wrapped in secondary package.In another example, secondary
Packaging can provide other barrier properties to help to extend the stability of component.
In one example, cylinder can be used together with automatic brewing apparatus and may be adapted to be assemblied in automatic brewing apparatus.?
In another example, cylinder can use in the case where not automatic brewing apparatus.
In one example, cylinder is disposable, it means that cylinder can be disposed or be lost after limited access times
It abandons.In one example, cylinder can be used five times or less times, in another example three times or less secondary, in another example
In it is twice or less secondary, and in another example cylinder be used only it is primary.In another example, cylinder is recycling and can
It is refilled with the component comprising active material and/or excipient.
Component may include one or more active materials and/or one or more excipient.Component can be at any suitable
Form, including but not limited to powder, liquid, gel or tablet.The non-limiting example of excipient may include flavoring agent, sweet tea
Taste agent, disintegrating agent, filler, pigment, lubricant, glidant, adsorbent, preservative, sensory agent and their combination.One
In a example, group is divided into the powder dissolved when water passes through cylinder.In another example, group be divided into when water pass through cylinder when can be dilute
The concentrated liquid released.In another example, component is only partly solubilized or is extracted to prepare beverage.
Cylinder may include one or more active materials.In one example, the beverage comprising active material can by adult and
12 years old or more children markets.In another example, the beverage comprising active material can be intended to usually be existed by children market
Under adult monitoring.
Active material can treat a variety of symptoms, including but not limited to the symptom as caused by flu, influenza or allergy.Activity
The non-limiting example of substance may include decongestant, expectorant, antihistamine, antitussive, antalgesic and their group
It closes.
In one example, more symptoms that cylinder can provide flu and/or flu symptom, which mitigate and can be intended for night, to be made
With.During single brew cycle, cylinder can deliver about 650mg paracetamol, about 30mg dextromethorphan HBr, about 10mg and go
Oxygen adrenaline, about 30 to about 60mg pseudoephedrine, and/or about 12.5mg doxylamine succinate.
In some instances, deliver that how many active material are not necessarily mean that this tin includes the active material of this amount.
Cylinder may be comprising than being delivered to the more active materials of user, because in some instances, and not all active material will be from
Cylinder is transferred to beverage.In addition, according to statutory regulation such as USP, the delivering amount of active material can thematic discussion amount 10% it
It is interior.
In another example, this tin can help to mitigate insomnia once in a while and/or can help if your difficulty falling asleep
Reduce the time fallen asleep.Cylinder can provide about 50mg diphenhydramine HCl or about 25mg doxylamine succinate.
In another example, which can help user to treat allergic symptom.The cylinder can deliver about 25mg to about 50mg
Diphenhydramine HCl, about 10mg Loratadine, about 650mg are more to about 1000mg paracetamol, about 7.5mg to about 12.5mg
Hila is quick, and/or about 10mg neo-synephrine.
In another example, cylinder can be sold in conjunction with other products, especially comprising over the counter active material or dimension life
The product of element and/or minerals.In one example, this tin may include being intended for catching a cold and/or night of flu symptom subtracts
Light active material and cylinder can be intended for catching a cold and/or the active material of flu symptom mitigated in the daytime is (such as to second
Acylamino- phenol, dextromethorphan and neo-synephrine) it combines packaging or sells.In another example, cylinder may include dimension life
Element, such as the tea comprising vitamin, and it can be with over the counter active material, such as the day comprising flu and/or flu symptom
Between and/or night mitigate active material combine packaging or sell.Over the counter active material can be any dosage form, including but unlimited
In liquid, solid dosage forms such as iquid capsule or tablet or cassette dosage form.
Automatic brewing apparatus can distribute the active material of entire dosage, as measured by disquisition.Therefore, brewed
When, active material is rapidly dissolvable or can be extracted in water.In one example, cylinder may include discussing dosage more than special topic
Active material has correct dosage in the cup to ensure consumer.Beverage can be any volume.In one example, it drinks
Material is about 100mL to about 500mL, is in another example about 125mL to about 250mL, is in another example about 130mL
It to about 250mL, and is in another example about 150mL to about 200mL.In one example, beverage is about 6 ounce fluid ounces
(177.41mL), and in another example, beverage is about 8 ounce fluid ounces (236.59mL).
In one example, after every use, automatic brewing apparatus can be rinsed with water or clean in other ways with
Remove remaining active material and/or excipient.For example, can in the machine without cylinder in the case where carried out by consumer it is brewed
Period.In one example, automatic brewing apparatus can be cleaned with water.In another example, detergent can be used, such as includes vinegar
Detergent cleans automatic brewing apparatus.Some consumers may also want to clean brewing apparatus before beverage brewed.
In one example, cylinder can for Childproof and the grading of referred to as F value can be given.F value refers to list
The quantity of position dosage, the unit dose close to the quantity are considered as test crash." F " subsequent number refers to based on 25 pounds
There may be serious personal injury or the quantity of the unit dose of serious disease by the children of (11.4kg).
Childproof test is a standard testing and is found in 1700 gas defence of 16C.F.R. § packaging.Show at one
In example, Childproof is packaged as F=1 packaging, is in another example F=2 packaging, is in another example F=3 packet
Dress is in another example F=4 packaging, and packs in another example for F=5.
In one example, non-accessible 5 cylinders of about 80% or more children or more in Childproof test
Content in few cylinder, in another example, the content in non-accessible 5 cylinders of about 70% or more children or less cylinder
Object, in another example, the content in non-accessible 5 cylinders of about 60% or more children or less cylinder.At another
In example, Childproof test in non-accessible 4 cylinders of about 80% or more children or less cylinder in content,
In another example, the content in non-accessible 4 cylinders of about 70% or more children or less cylinder, in another example
In, the content in non-accessible 4 cylinders of about 60% or more children or less cylinder.In another example, child-resistant is opened
The content in non-accessible 3 cylinders of about 80% or more children or less cylinder in the test of opening property, in another example,
Content in non-accessible 3 cylinders of about 70% or more children or less cylinder, in another example, about 60% or more
Non-accessible 3 cylinders of children or less cylinder in content.In another example, the pact in Childproof test
Content in non-accessible 2 cylinders of 80% or more children or less cylinder, in another example, about 70% or more
Content in non-accessible 2 cylinders of children or less cylinder, in another example, about 60% or more children are non-accessible
Content in 2 cylinders or less cylinder.
Test method
Childproof test
Can be the 16th according to Code of Federal Regulations: the 1700th part carries out Childproof test.
Childproof screening test
It can carry out as follows Childproof screening test:
For Childproof screening test, children are between the 42-51 monthly age.Boy is selected with the quantity of approaches uniformity
And girl.
Test crash is defined as obtaining close any children to cylinder content.For following experiment, if any youngster
Child during entire 10 minutes of test close to the content of three or more, then test crash.As used herein,
" acquisition pair ... close " refers to that active material has been taken out or can be removed completely or partially.For cylinder, if
The active material that cylinder is inverted former any quantity can spill outside cylinder, then active material can be removed.If cylinder or packaging are destroyed simultaneously
And content is not removed but can be removed, then this be still considered as it is close.
Once two children of test.Two children are accompanied to test zone and take a seat them, so as in children and survey
There is no physical barriers between examination person.Tester will talk with children so that they loosen.Not to children in contest or the sense of match
Feel, do not awarded to them, and does not tell that their tests are that game or test are interesting.To start to test, tester should be given
The identical cylinder of children and say " please attempt that me is helped to open this ".If children refuse to participate in after test has begun, that
Tester should comfort children and softly children be encouraged to attempt.If children continue to refuse, tester should be required
It is above-knee until another children terminates that cylinder is placed on his/her by child.This should not remove children from result, unless refusal
Children upset the participation of another children.
Each children will be given 5 minutes to open his/her cylinder.Tester should make to minimize with the talk of children, as long as
They continue to attempt to open their cylinder.Tester should not prevent children with language form or using facial expression.If
Children become dejected or bored and cease attempt to open his/her cylinder, then tester should comfort children and softly rouse
Children are encouraged to keep punching.Children should be allowed to move freely the cylinder to be dedicated to them, as long as two children can be seen i.e. in tester
It can (such as they can stand, be sitting on floor or fiercely attack or agitate packaging).Children should be allowed to talk to each other about cylinder is opened
And them should be allowed to look to attempt to open packaging each other.If children open his/her cylinder, tester should say " thank you " simultaneously
And open cylinder is taken away from children and gives children's cylinder that another is not switched on.
At the end of 5 minutes section, tester should require children to put down their cylinder and then should show how to beat
Open cylinder.By carry out how machine (K75Platinum Edition brewing apparatus) in using the displaying of cylinder come into
This displaying of row.During showing the period, children should not be allowed to continue to attempt to open their cylinder.Tester, which should say, " sees me
Use this packaging ".Once tester obtains whole concerns of children, tester should hold demonstration packaging from about two English of children
Ruler and with normal speed open pack, just as tester will use content.There should not be excessive open movement.It surveys
Examination person should not discuss or describe how to open packaging.After opening packaging, tester should be to children's display packing.
Then, attempt to open their cylinder to second five-minute period section of children.Tester by says " it is present you
Attempt to open your cylinder " start five minutes periods.If two children first during 5 minutes without using him
Tooth attempt to open their cylinder, then tester should be just before starting second 5 minutes section or at it
Say " your tooth can be used in you, if you think " immediately later.This is that tester should be about using tooth institute
The unique statement done.Test should continue another five minutes or until two children open their packaging, whichever
It arrives first.
Embodiment 1
Embodiment 1 shows the result from Childproof screening test.It follows as previously discussed for Childproof
The program of screening test.Test uses Swiss Miss(on October 25th, 2013 is bought on Keurig.com,
Lot number 6696PL120, January 17 2015 validity period).Following table 1, which is shown, to be opened how many cylinder and opens what each spent
Time.Table 2 describes how open each cylinder is approached.
Table 1
* giving children, there is the cylinder for reinforcing top to continue second five minute testing time section.It is fiber reinforced using utilizing
Packaging strip reinforce top.Band is attached to Swiss MissCapping on and using hot plate item is brought into
One step is bonded to capping.
Table 2
Utilize Swiss MissChildproof screening test have 65% percent of pass.If youngster
Child opens two or less cylinders, then container passes through.For comprising drug products, especially including paracetamol or benzene
For the beverage products of the product of extra large Lamine, this is that unacceptable Childproof is horizontal.It is nearly all close to content
Children used their tooth pierce through capping.Therefore, in order to prepare the cylinder of Childproof, having can not be by biting
It pierces through or the capping of tearing may be important.One children by with his thumb apply stable pressure pierce through foil capping come
Open packaging.Therefore, if capping not readily passes through extruding and is opened, it can also be prepared to Childproof.
In addition what is interesting is noticing after children watch and show and be apprised of the tooth that they can be used, more
Children obtain to the close of the content of cylinder.In addition, he or she usually can be very if children can open a cylinder
Quickly open remaining cylinder.Therefore, in order to enable cylinder is Childproof, it may be necessary to so that cylinder is tear-resistant.
Although not being Childproof with the cylinder that packaging strip is reinforced, it takes children's longer time really
Carry out the content close to these.Therefore, if heat seal is stronger, the Childproof characteristic of packaging can be improved.
Although receiving has two children of the cylinder for reinforcing top can be close to content, they cannot be by biting
Or it pierces through reinforcing strip in other ways and brings close to content.On the contrary, they can by stripping by reinforcing strip band with
Capping separates.Therefore, if packaging strip is more firmly attached to capping, such as in laminate structure, then foot can be realized
Enough Childproofs are horizontal.
Embodiment 2
Embodiment 2 shows from the second Childproof screening test as a result, the test is using it is believed that better than embodiment 1
The middle lamilate closure construction those of tested.Follow the program for being used for Childproof screening test as previously discussed.It should
Embodiment uses base portion same as Example 1;However capping has different laminate structures.Lamilate has outer layer, the
Two layers and internal layer.Outer layer is 12 μm of PET, and the second layer is 9 μm of foils, and internal layer is 25 μm of LLDPE.Outer layer utilizes bonding
Agent is connected to the second layer and the second layer is connected to internal layer using adhesive.Cylinder is filled with(lot number #
401158801G).Following table 3, which is shown, to be opened how many cylinder and opens each time spent.Table 4 is described to be opened in child-resistant
Method used in each children of three or more is opened during opening screening test.Age group is as follows: the A=42-44 month is big,
The B=45-48 month is big, and the C=49-51 month is big.
Table 3
The mode of the product of the product of the close method for being used to prepare the prototype sample for test of * children discovery.
It is believed that normal manufacture would not allow for this mean of access success.
Table 4
#12 children are counted in 75% using this Childproof screening test that the lamilate of embodiment 2 covers
Percent of pass, and if he is excluded with 80% percent of pass.If children open three or less cylinders, container
Pass through.For comprising drug products, for the beverage products of the product especially comprising paracetamol or diphenhydramine,
75% is that unacceptable Childproof is horizontal (80% is minimum acceptable level).Nearly all youngster close to content
Child has used their tooth or finger to pierce through capping.Therefore, in order to prepare the cylinder of Childproof, having can not be by gnawing
The capping for stinging puncture or tearing may be important.
Embodiment 3
Embodiment 3 shows from third Childproof screening test as a result, the test is using it is believed that better than embodiment 1
With the new wrapper component material those of tested in embodiment 2.It follows and is surveyed as previously discussed for Childproof screening
The program of examination.Test uses base portion same as Example 1;However capping has different laminate structures.Lamilate has
Outer layer, the second layer and internal layer.Outer layer is 23 μm of PET, and the second layer is 18 μm of foils, and internal layer is 25 μm of LLDPE.Outer layer
The second layer is connected to using adhesive and the second layer is connected to internal layer using adhesive.Cylinder is filled with(lot number #
401158801G).Following table 5, which is shown, to be opened how many cylinder and opens each time spent.Table 6 is described to be opened in child-resistant
Method used in each children of three or more is opened during opening screening test.Age group is as follows: the A=42-44 month is big,
The B=45-48 month is big, and the C=49-51 month is big.
Table 5
Table 6
There is 90% percent of pass using this Childproof screening test that the lamilate of embodiment 3 covers.Such as
Fruit children open three or less cylinders, then container passes through.For comprising drug products, especially including paracetamol
Or for the beverage products of the product of diphenhydramine, 90% is acceptable Childproof level, and (80% is minimum connect
By level).
It is to be appreciated that dimension disclosed herein and value, which are not intended to, is strictly limited to cited exact numerical.On the contrary, unless
Otherwise indicated, otherwise each such dimension is intended to indicate that described value and the range functionally equivalent around the value.For example, public
It opens and is intended to indicate that " about 40mm " for the dimension of " 40mm ".
It is limited unless expressly excluded or in other ways, each document cited herein, including any intersection
Reference or related patents or application and the application is claimed priority to it or any patent application or patent of its advantages,
It is incorporated by reference and is incorporated herein accordingly.The reference of any document is not to it as disclosed herein or by right
The prior art of any invention of claim protection or its individually or any combination with any other bibliography, or
With reference to, propose, suggest or disclose the approval of any such invention.In addition, when the present invention in term any meaning or definition with
In file incorporated by reference any meaning of same term or define contradiction when, should obey in the present invention assign should
The meaning or definition of term.
Although specific embodiments of the present invention have had been illustrated and described, those skilled in the art are come
It says it is readily apparent that a number of other changes and modification can be made without departing substantially from spirit and scope of the present invention.Cause
This, is intended to all these changes and the modification covered in appended claims and belonged in the scope of the invention.
Claims (9)
1. a kind of suitable for the cylinder for the Childproof being used together with automatic brewing apparatus, comprising:
A. base portion, wherein the base portion includes pharmaceutically active substance;With
B. cover, wherein it is described capping include multilayer laminate, the multilayer laminate include PET outer layer, the foil second layer and
LLDPE internal layer;
Wherein the cylinder prevents 90% children close to the content of more than three cylinder during Childproof screening test;
Wherein the outer layer is at least 23 μ m-thicks, and the second layer is at least 18 μ m-thicks, and wherein the internal layer is at least 25 μ
M is thick, and the layer is bonded together using LDPE;And
Wherein the capping does not include mesh sheet stiffener, and
Wherein the capping includes atenuator region, and from 3mm to 8mm, the atenuator region does not exist the widest point of the atenuator region
It can be penetrated on the outer layer of the capping and by the syringe needle of automatic brewing apparatus or other penetration devices.
2. the cylinder of Childproof according to claim 1, wherein the cylinder includes 2 × 10-5To 2 × 10-3G//day
Final moisture transmission.
It further include excipient and the wherein excipient and described 3. the cylinder of Childproof according to claim 1
Pharmaceutically active substance is powder.
It further include excipient and the wherein excipient and described 4. the cylinder of Childproof according to claim 1
Pharmaceutically active substance is concentrated liquid.
5. the cylinder of Childproof according to claim 1, wherein the base portion further includes first compartment and second compartment,
The first compartment includes the pharmaceutically active substance, and the second compartment includes the second pharmaceutically active substance, wherein described the
One compartment and the second compartment are separated by separator.
6. the cylinder of Childproof according to claim 5, wherein the separator is mesh sheet.
7. the cylinder of Childproof according to claim 5, wherein the pharmaceutically active substance and second drug are living
Property substance is incompatible.
8. the cylinder of Childproof according to claim 1, wherein the pharmaceutically active substance includes paracetamol
And wherein the cylinder can deliver the paracetamol of 650mg during brew cycle.
9. the cylinder of Childproof according to claim 1, wherein the cylinder contains pharmaceutically active substance, the drug is living
Property substance include diphenhydramine and optionally paracetamol, and wherein the cylinder can deliver during brew cycle
The diphenhydramine of 50mg.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361909556P | 2013-11-27 | 2013-11-27 | |
US61/909,556 | 2013-11-27 | ||
PCT/US2014/067518 WO2015081145A1 (en) | 2013-11-27 | 2014-11-26 | Beverage cartridge containing pharmaceutical actives |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105848625A CN105848625A (en) | 2016-08-10 |
CN105848625B true CN105848625B (en) | 2019-07-09 |
Family
ID=52014447
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Application Number | Title | Priority Date | Filing Date |
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CN201480064906.8A Expired - Fee Related CN105848625B (en) | 2013-11-27 | 2014-11-26 | Beverage cartridge comprising pharmaceutically active substance |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP3073981B1 (en) |
CN (1) | CN105848625B (en) |
AU (2) | AU2014354787B2 (en) |
CA (1) | CA2929863A1 (en) |
MX (1) | MX2016006449A (en) |
RU (1) | RU2669392C1 (en) |
WO (1) | WO2015081145A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102015011169B4 (en) * | 2015-09-01 | 2018-12-20 | LigaLife GmbH & Co. KG | Capsule for a production of a liquid food |
DE102015115250A1 (en) * | 2015-09-10 | 2017-03-16 | Pester Pac Automation Gmbh | Use of a packaging |
US20170280929A1 (en) | 2016-03-30 | 2017-10-05 | Eco 2, Llc | Descaling device for a beverage machine and method of descaling a beverage machine |
IT201600111266A1 (en) * | 2016-11-04 | 2018-05-04 | Safta Spa | CAPSULE, MANUFACTURING METHOD, MULTILAYER FILM |
US10881582B2 (en) * | 2018-06-11 | 2021-01-05 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Individual dose pack |
WO2020039411A2 (en) * | 2019-09-28 | 2020-02-27 | Famatek Gmbh | Capsule comprising a main and a supplemental precursor ingredient, method for production of said capsule and method for preparing a beverage |
GR1010650B (en) * | 2023-01-17 | 2024-03-12 | Ιουλια Κλεωνος Τσετη | Pharmaceutical water-soluble paraketamol composition contained in a hermetically closed container for the preparation of beverages |
Citations (3)
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CN102018446A (en) * | 2004-02-18 | 2011-04-20 | Mds环球控股有限公司 | Dispensing of a substance |
CN102753062A (en) * | 2009-12-18 | 2012-10-24 | 绿山咖啡烘培公司 | Beverage formation apparatus and method using sonic energy |
CN102843938A (en) * | 2010-02-01 | 2012-12-26 | 绿山咖啡烘培公司 | Method and apparatus for cartridge-based carbonation of beverages |
Family Cites Families (4)
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US9936834B2 (en) * | 2010-02-01 | 2018-04-10 | Bedford Systems Llc | Method and apparatus for cartridge-based carbonation of beverages |
DE102011052149A1 (en) * | 2011-07-26 | 2013-01-31 | Cavonic GmbH | Packaging container, manufacturing method and manufacturing device |
ES2675313T3 (en) * | 2012-03-26 | 2018-07-10 | Sarong Societa' Per Azioni | Beverage capsule and methods for manufacturing said capsule |
WO2014127467A1 (en) * | 2013-02-25 | 2014-08-28 | 2266170 Ontario Inc. | Single serve capsule for improved extraction efficiency and flavor retention |
-
2014
- 2014-11-26 RU RU2016118811A patent/RU2669392C1/en not_active IP Right Cessation
- 2014-11-26 EP EP14809262.0A patent/EP3073981B1/en not_active Not-in-force
- 2014-11-26 AU AU2014354787A patent/AU2014354787B2/en not_active Ceased
- 2014-11-26 CA CA2929863A patent/CA2929863A1/en not_active Abandoned
- 2014-11-26 MX MX2016006449A patent/MX2016006449A/en active IP Right Grant
- 2014-11-26 WO PCT/US2014/067518 patent/WO2015081145A1/en active Application Filing
- 2014-11-26 CN CN201480064906.8A patent/CN105848625B/en not_active Expired - Fee Related
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2017
- 2017-10-12 AU AU2017245390A patent/AU2017245390B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102018446A (en) * | 2004-02-18 | 2011-04-20 | Mds环球控股有限公司 | Dispensing of a substance |
CN102753062A (en) * | 2009-12-18 | 2012-10-24 | 绿山咖啡烘培公司 | Beverage formation apparatus and method using sonic energy |
CN102843938A (en) * | 2010-02-01 | 2012-12-26 | 绿山咖啡烘培公司 | Method and apparatus for cartridge-based carbonation of beverages |
Also Published As
Publication number | Publication date |
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CA2929863A1 (en) | 2015-06-04 |
AU2014354787A1 (en) | 2016-05-19 |
MX2016006449A (en) | 2016-07-19 |
RU2016118811A (en) | 2017-12-28 |
AU2017245390B2 (en) | 2019-03-07 |
AU2014354787B2 (en) | 2017-08-10 |
AU2017245390A1 (en) | 2017-11-02 |
EP3073981A1 (en) | 2016-10-05 |
RU2669392C1 (en) | 2018-10-11 |
WO2015081145A1 (en) | 2015-06-04 |
EP3073981B1 (en) | 2019-07-24 |
CN105848625A (en) | 2016-08-10 |
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