CN105842641A - Multi-channel three-dimensional magnetic resonance imaging method based on 1H-19F-31P nucleus - Google Patents
Multi-channel three-dimensional magnetic resonance imaging method based on 1H-19F-31P nucleus Download PDFInfo
- Publication number
- CN105842641A CN105842641A CN201610137132.8A CN201610137132A CN105842641A CN 105842641 A CN105842641 A CN 105842641A CN 201610137132 A CN201610137132 A CN 201610137132A CN 105842641 A CN105842641 A CN 105842641A
- Authority
- CN
- China
- Prior art keywords
- image
- array coil
- phased
- magnetic resonance
- nucleus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/561—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
- G01R33/5615—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Signal Processing (AREA)
- General Health & Medical Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention discloses a multi-channel three-dimensional magnetic resonance imaging method based on the 1H-19F-31P nucleus. The method comprises the steps of scanning a part to be imaged by using a multi-channel phased-array coil and a magnetic resonance pulse sequence 1H/19F/31PPANSY-COSY-3D fbSSFP, and obtaining a plurality of phased-array coil images which are a 31P nucleus image, a 1H nucleus image and a 19F nucleus image respectively; and conducting registration and image fusion processing for the plurality of phased-array coil images and then obtaining a nuclear magnetic resonance image capable of providing tumor molecule information and metabolic information. The invention not only has a great practical significance in the early diagnosis of tumor, the improvement in the quality of life of patients, the improvement in the cure rate of tumor and the like, but also has a great strategic significance for our country to get rid of the shackles of foreign medical technology, break through the monopoly of foreign medical technology, and to occupy a world leading position in medical imaging, oncology and so forth.
Description
Technical field
The present invention relates to magnetic resonance imaging method employing, in particular to one based on 1H-19F-31P nuclear multichannel three-dimensional NMR formation method.
Background technology
At present, nuclear magnetic resonance, NMR (NMR) imaging technique is widely used in medical diagnosis, and NMR (Nuclear Magnetic Resonance)-imaging is as computer technology, electronic circuit technology, the development of superconductor technology and a kind of biomagnetism nuclear spin imaging technique of developing rapidly.It is to utilize magnetic field and radio-frequency pulse to make the proton (i.e. H+) of precession in tissue occur resonance to produce radiofrequency signal, then processes and imaging through computer.Proton is the first-selected nucleic of human body imaging, and owing to the various tissue of human body all contains substantial amounts of water and Hydrocarbon, so the nmr sensitivity of proton is high, signal is strong, therefore people's first-selection proton is as human body imaging element.NMR signal intensity is relevant with proton density in sample, and the moisture ratio of the various tissue of human body is different, causes NMR signal intensity variant, utilizes this species diversity as characteristic quantity by various tissues separately, to obtain nuclear magnetic resonance image.Proton density, relaxation time T1, the difference of tri-parameters of T2 between pathological tissues between human body different tissues, in normal structure and this tissue, be that MRI is for the topmost physical basis of clinical diagnosis.
But, traditional core mr techniques can only provide dissection level image information, only tumor development just can be diagnosed to middle and advanced stage, causes a lot of tumor patient to lose tumor golden hour.Therefore, how disease is carried out molecular image diagnosis, so that pathological changes just can be detected in early days in tumor and determine lesions position, thus improve the life quality of tumor patient and improve tumor cure rate, being an important directions of those skilled in the art's future studies.
Summary of the invention
The present invention provides a kind of based on 1H-19F-31P nuclear multichannel three-dimensional NMR formation method, to obtain providing the nuclear magnetic resonance image of tumor cells information and metabolic information.
In order to achieve the above object, the invention provides a kind of based on 1H-19F-31P nuclear multichannel three-dimensional NMR formation method, comprise the following steps:
S1: multiple coil units are formed a multichannel phased-array coil；
S2: use multichannel phased-array coil and magnetic resonance pulse sequence 1H/19F/31P PANSY COSY 3D fbSSFP to be scanned being intended to imaging position, obtaining multiple phased-array coil image, multiple phased-array coil images are respectively 31P atomic nucleus image, 1H atomic nucleus image and 19F atomic nucleus image；
S3: form, the image size and resolution of multiple phased-array coil images are set to unanimously, and multiple phased-array coil images are carried out filter make an uproar process and contrast enhancement processing；
S4: multiple phased-array coil images are carried out spatial registration and geometrical registration, makes to represent the pixel of same anatomical or voxel one_to_one corresponding；
S5: with maximum mutual information for according to each phased-array coil image is carried out analysis of the accuracy, counting wrong data therein, wrong data is modified by the AM method of estimation in application robust estimation method；
S6: calculate the image variance of each several part in multiple phased-array coil image, gives different weighted values according to the size of each several part image variance to each several part.Give less weighted value to the part that image variance is bigger, give bigger weighted value to the part that image variance is smaller, wherein, be exponential function relation between described weighted value and described image variance；
Square being multiplied with the gray value of correspondence image part of S7: described weighted value, and multiple phased-array coil images are weighted, with the image after being merged；
S8: by identifying Quality Map data, from phase diagram from the beginning of mass value maximum pixel point, by the order of phase masses height, phase diagram is carried out path integral, finally launch the unreliable region that mass value is relatively low, so that inevitable error is confined in minimum zone, thus obtain preferable phase unwrapping result, separate by the residual error region of sound pollution so that it is his phase unwrapping of part is interference-free.
In one embodiment of this invention, targeting analysis and Real Time Observation fuselage state on a cellular level is reached by the fusion of multimode, reach dynamic molecular imaging, further disease is carried out molecule parting, it is finally reached " live body pathology " diagnosis, i.e. from macro and micro macroscopic view, from molecular level energies metabolism nuclear magnetic resonance.
The ultrahigh resolution nuclear magnetic resonance image that can be provided tumor cells information and metabolic information based on 1H-19F-31P nuclear multichannel three-dimensional NMR formation method that the present invention provides, therefore, it is possible to realize the diagnosis to tumor at the pathological changes initial stage.The present invention not only at early diagnosis of tumor, improve life in patients, improve the aspect such as tumor cure rate there is Great significance, and the constraint of foreign medical science technology is broken away from for China, break foreign medical science technical monopoly, and occupy rank first at the aspect such as Medical Imaging, oncology there is great strategic significance.
Detailed description of the invention
Below the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under not paying creative work premise, broadly fall into the scope of protection of the invention.
The present invention uses magnetic resonance pulse sequence 1H/19F/31P PANSY COSY 3D fbSSFP to be scanned being intended to imaging position, and its reason is that 19F core has the advantage that in NMR studies
(1) spin quantum number of 19F core is 1/2, abundance 100% at nature, 19F core has the highest sensitivity in NMR, it is the 83% of 1H sensitivity, there is stronger dipole cooperation use, can be by measuring exposing as distance restraint, the topology of analysing protein and solvent between 19F-19F and 19F-1H.
(2) in native protein, do not have 19F core, therefore there is no the interference of background signal, significant to analysing protein complex in the case of live body.
(3) being affected by paramagnetic properties, 19F is very sensitive to Van der Waals force and the electric field action power of local.Meanwhile, the chemical shift of 19F is very sensitive to surrounding, the different medium condition of H2O and D2O, it is possible to make the chemical shift of 19F change.
(4) chemical shift range of 19F is wider 100 times than 1H, adds that the sensitivity of 19F core makes 19F have good resolution in one-dimensional spectrum.
(5) one-dimensional 19F spectrum can be used for studying low concentration protein, than the sampling time much shorter of multidimensional 1H spectrum.
(6) wider chemical shift contributes to studying the kinetics of protein, because frequency domain spectra is extended to the widest scope, is conducive to detecting weak combination, folding process, the kinetics of enzyme and conformation change and relevant physically and thermally mechanical characteristic.
(7) add paramagnetic meterial and can increase the 19F chemical shift quick sexuality to microenvironment.Water solublity or hydrophobic paramagnetic probes may be used for studying topology information, as solvent exposes and hydrophobicity analysis.
(8) 19F mix the least to the structural perturbation of protein, the van der Waals radius of 19F is only than 1H big 20%.
Phosphorus is the important elements of energy metabolism, and in human body, chemical compound lot all contains phosphorus.The research biological tissue organ metabolism of this brand-new 1H-19F-31P (multinuclear) MR imaging apparatus hurtless measure, Biochemical changes and the method for compound quantitative analysis of design at present, the different metabolic between tumor and normal structure can be shown, pathologic condition can be reflected on a molecular scale.Meanwhile, the spectrum information of multiple voxel and the spatial distribution image of metabolite can be obtained, it is contemplated that after one of the important detection instrument becoming 21 century middle and late stage molecular level.
Compared with 1H, the sensitivity of 31P is the lowest, the 6.65% of only 1H, but in organism, many molecules all contain 31P, and many phosphorus-containing compounds participate in the energy metabolism of cell and the phospholipid metabolism relevant with biomembrane.The main energy metabolism reflecting human tissue cell of phosphorus spectrum changes, and the concentration of phosphide is closely related with energy metabolism, and the relative concentration of mensuration phosphorus metabolism product and distribution can determine that the energy state of cell.As far back as 1973, Moon and Richards carried out 31P frequency spectrum and has measured intact red blood cells and in vitro fresh muscle specimen.Magnetic resonance spectroscopy imaging technique grows up on the basis of MRI technique, more with better function than MRI, the physicochemical environment of sample Middle molecule internal spin core (such as 1H31P19F and 23Na13C) can be detected, can the information of pathological changes in molecular level reflection organism or in human body, improve the early diagnosis to diseases such as such as alzheimer disease, epilepsy, cerebromas and curative effect monitoring capacity.And this equipment is selected the essence on the basis of combining the existing equipment such as conventional magnetic resonance and functional MRI, merge multidisciplinary advanced technology, multiple nmr imaging technology will become one of 21 century biomedical research important detection instrument entering molecular level, the observation of organizational structure can be combined with the research of metabolic function, be one the most potential live body biochemical analysis method.
1H-19F-31P three is fused together the multiple nmr imaging designed not only can analyze image from traditional dissection aspect, more can to analyze more accurately image from molecular targeted aspect and tissue metabolism's level, thus reach the molecular diagnosis on iconography.
The invention provides a kind of based on 1H-19F-31P nuclear multichannel three-dimensional NMR formation method, comprise the following steps:
S1: multiple coil units are formed a multichannel phased-array coil；
S2: use multichannel phased-array coil and magnetic resonance pulse sequence 1H/19F/31P PANSY COSY 3D fbSSFP to be scanned being intended to imaging position, obtaining multiple phased-array coil image, multiple phased-array coil images are respectively 31P atomic nucleus image, 1H atomic nucleus image and 19F atomic nucleus image；
When desire imaging position is scanned, select corresponding scanning sequence according to the different parts of patient and the difference of position and monitoring of diseases.Owing to traditional magnetic resonance imaging sequence can only gather 1H, so must add, during scanning, the novel sequences that 31P and 19F can be gathered on the basis of original.
S3: form, the image size and resolution of multiple phased-array coil images are set to unanimously, and multiple phased-array coil images are carried out filter make an uproar process and contrast enhancement processing；
S4: multiple phased-array coil images are carried out spatial registration and geometrical registration, makes to represent the pixel of same anatomical or voxel one_to_one corresponding；
S5: with maximum mutual information for according to each phased-array coil image is carried out analysis of the accuracy, counting wrong data therein, wrong data is modified by the AM method of estimation in application robust estimation method.
Medical Image Registration based on maximum mutual information is a kind of based on image pixel gray level the method being widely used recent years.Mutual information comes from theory of information, it is used for weighing the similarity degree between two stochastic variables, it need not selection marker point or extracts the feature of image, also without assuming that in image, the gray value of pixel exists certain linear relationship, therefore, it is a kind of effective ways carrying out multimodal medical image registration.In field of medical images, mutual information is with being the number expressing another width image information with piece image, and the similarity degree of i.e. two width images, so we carry out analysis of the accuracy to each phased-array coil image on this basis.
S6: calculate the image variance of each several part in multiple phased-array coil image, gives different weighted values according to the size of each several part image variance to each several part.Give less weighted value to the part that image variance is bigger, give bigger weighted value to the part that image variance is smaller, wherein, be exponential function relation between weighted value and image variance；
The weighted value introduced herein according to the size of each several part image variance.Consider the relation between each pixel in medical image, the spatial information of two width images subject to registration is incorporated in registration process so that registration result is smoother, robustness is more preferable, it is not easy to be absorbed in local extremum.
Square being multiplied with the gray value of correspondence image part of S7: weighted value, and multiple phased-array coil images are weighted, with the image after being merged；
S8: by identifying Quality Map data, from phase diagram from the beginning of mass value maximum pixel point, by the order of phase masses height, phase diagram is carried out path integral, finally launch the unreliable region that mass value is relatively low, so that inevitable error is confined in minimum zone, thus obtain preferable phase unwrapping result, separate by the residual error region of sound pollution so that it is his phase unwrapping of part is interference-free.
Being directed to 31P, we use for reference 3D fully-balanced steady-state free precession (fbSSFP) sequence of knowing clearly.The fewest to this sequence research at home, after consulting a large amount of foreign language literature, take the lead in introducing among multiple nmr imaging sequence this.Main technical principle applies the European effect of nuclear-magnetism (NOE).NOE effect (nuclear Overhauser effect) is a kind of peculiar physical phenomenon first proposed by Overhauser nineteen fifty-three.At present, the research of NOE effect and the exploitation of experimental technique are still the focus in nuclear-magnetism field.1H-31P is associated on the basis of fbSSFP sequence by we.FbSSFP sequence can effectively improve signal to noise ratio, improves image resolution ratio.3D fbSSFP sequence applies NOE segmentation pulse and strengthens the signal of 31P, also improves the sensitivity of phosphagen monitoring in tissue simultaneously.
The present invention reaches targeting analysis and Real Time Observation fuselage state on a cellular level by the fusion of multimode, reach dynamic molecular imaging, further disease is carried out molecule parting, it is finally reached " live body pathology " diagnosis, i.e. from macro and micro macroscopic view, from molecular level energies metabolism nuclear magnetic resonance.
The ultrahigh resolution nuclear magnetic resonance image that can be provided tumor cells information and metabolic information based on 1H-19F-31P nuclear multichannel three-dimensional NMR formation method that the present invention provides, therefore, it is possible to realize the diagnosis to tumor at the pathological changes initial stage.The present invention not only at early diagnosis of tumor, improve life in patients, improve the aspect such as tumor cure rate there is Great significance, and the constraint of foreign medical science technology is broken away from for China, break foreign medical science technical monopoly, and occupy rank first at the aspect such as Medical Imaging, oncology there is great strategic significance.
Last it is noted that above example is only in order to illustrate technical scheme, it is not intended to limit；Although the present invention being described in detail with reference to previous embodiment, it will be understood by those within the art that: the technical scheme described in previous embodiment still can be modified by it, or wherein portion of techniques feature is carried out equivalent；And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (2)
1., based on a 1H-19F-31P nuclear multichannel three-dimensional NMR formation method, it is special
Levy and be, comprise the following steps:
S1: multiple coil units are formed a multichannel phased-array coil；
S2: use multichannel phased-array coil and magnetic resonance pulse sequence 1H/19F/31P PANSY
COSY 3D fbSSFP is scanned being intended to imaging position, obtains multiple phased-array coil image, multiple
Phased-array coil image is respectively 31P atomic nucleus image, 1H atomic nucleus image and 19F atomic nucleus image；
S3: form, the image size and resolution of multiple phased-array coil images are set to unanimously, and
Multiple phased-array coil images are carried out filter make an uproar process and contrast enhancement processing；
S4: multiple phased-array coil images are carried out spatial registration and geometrical registration, makes to represent same anatomical
The pixel of structure or voxel one_to_one corresponding；
S5: with maximum mutual information for according to each phased-array coil image is carried out analysis of the accuracy, unite
Counting out wrong data therein, wrong data is carried out by the AM method of estimation in application robust estimation method
Revise；
S6: calculate the image variance of each several part in multiple phased-array coil image, according to each several part figure image space
Extent gives different weighted values to each several part, gives less to the part that image variance is bigger
Weighted value, gives bigger weighted value to the smaller part of image variance, wherein, described weighted value with
It it is exponential function relation between described image variance；
Square being multiplied with the gray value of correspondence image part of S7: described weighted value, and by multiple phased array
Coil image is weighted, with the image after being merged；
S8: by identifying Quality Map data, from phase diagram from the beginning of mass value maximum pixel point, by phase place
The order of quality height carries out path integral to phase diagram, finally launches the unreliable region that mass value is relatively low,
Inevitable error to be confined in minimum zone, thus obtain preferable phase unwrapping result, point
From by the residual error region of sound pollution so that it is his phase unwrapping of part is interference-free.
The most according to claim 1 common based on 1H-19F-31P nuclear multichannel three-dimensional nuclear-magnetism
Shake formation method, it is characterised in that reaches targeting analysis and on a cellular level by the fusion of multimode
Real Time Observation fuselage state, reaches dynamic molecular imaging, further disease is carried out molecule parting, finally
Reach " live body pathology " diagnosis, i.e. from macro and micro macroscopic view, from molecular level energies metabolism
Nuclear magnetic resonance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610137132.8A CN105842641A (en) | 2016-03-10 | 2016-03-10 | Multi-channel three-dimensional magnetic resonance imaging method based on 1H-19F-31P nucleus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610137132.8A CN105842641A (en) | 2016-03-10 | 2016-03-10 | Multi-channel three-dimensional magnetic resonance imaging method based on 1H-19F-31P nucleus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105842641A true CN105842641A (en) | 2016-08-10 |
Family
ID=56587057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610137132.8A Pending CN105842641A (en) | 2016-03-10 | 2016-03-10 | Multi-channel three-dimensional magnetic resonance imaging method based on 1H-19F-31P nucleus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105842641A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111386462A (en) * | 2017-11-13 | 2020-07-07 | 慕尼黑科技大学 | Automated noninvasive determination of egg fertility |
| CN113331815A (en) * | 2020-03-02 | 2021-09-03 | 哈尔滨医科大学 | Multi-core radio frequency coil transceiving and ultrasonic array unit synchronous control device and method |
| CN113552515A (en) * | 2021-06-29 | 2021-10-26 | 上海辰光医疗科技股份有限公司 | Dual-core imaging method for animal magnetic resonance imaging |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116079A (en) * | 1994-05-31 | 1996-02-07 | 岛津制作所株式会社 | Magnetic resonance imaging device |
| CN102283649A (en) * | 2011-05-11 | 2011-12-21 | 浙江大学 | Selective excitation sequential design method for magnetic resonance imaging in three-dimensional space |
| CN102762997A (en) * | 2010-02-22 | 2012-10-31 | 皇家飞利浦电子股份有限公司 | RF antenna arrangement and method for multi nuclei MR image reconstruction involving parallel MRI |
| CN103228297A (en) * | 2010-12-10 | 2013-07-31 | 默克专利股份公司 | Aptamer labeled with F-19 nucleus for targeted molecular imaging by MRI |
| CN104107045A (en) * | 2014-06-30 | 2014-10-22 | 沈阳东软医疗系统有限公司 | Magnetic resonance imaging method and device |
| CN104156913A (en) * | 2014-07-15 | 2014-11-19 | 电子科技大学 | Automatic optic inspection method for surface defects of metal cylindrical workpieces |
-
2016
- 2016-03-10 CN CN201610137132.8A patent/CN105842641A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116079A (en) * | 1994-05-31 | 1996-02-07 | 岛津制作所株式会社 | Magnetic resonance imaging device |
| CN102762997A (en) * | 2010-02-22 | 2012-10-31 | 皇家飞利浦电子股份有限公司 | RF antenna arrangement and method for multi nuclei MR image reconstruction involving parallel MRI |
| CN103228297A (en) * | 2010-12-10 | 2013-07-31 | 默克专利股份公司 | Aptamer labeled with F-19 nucleus for targeted molecular imaging by MRI |
| CN102283649A (en) * | 2011-05-11 | 2011-12-21 | 浙江大学 | Selective excitation sequential design method for magnetic resonance imaging in three-dimensional space |
| CN104107045A (en) * | 2014-06-30 | 2014-10-22 | 沈阳东软医疗系统有限公司 | Magnetic resonance imaging method and device |
| CN104156913A (en) * | 2014-07-15 | 2014-11-19 | 电子科技大学 | Automatic optic inspection method for surface defects of metal cylindrical workpieces |
Non-Patent Citations (5)
| Title |
|---|
| 卢振泰: "《基于最大互信息量的图像自动优化分割》", 《中国图像图形学报》 * |
| 岑小林: "《质量图和残差点相结合的InSAR相位解缠方法》", 《遥感技术与应用》 * |
| 张娟: "《医学图像配准中相似性测度的研究》", 《博士论文》 * |
| 张晓秋: "《基于质量图的相位展开方法研究》", 《硕士论文》 * |
| 张雷: "《基于多权重概率图谱的脑部图像分割》", 《硕士论文》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111386462A (en) * | 2017-11-13 | 2020-07-07 | 慕尼黑科技大学 | Automated noninvasive determination of egg fertility |
| CN111386462B (en) * | 2017-11-13 | 2024-02-23 | 慕尼黑科技大学 | Automatic noninvasive determination of fertility of poultry eggs |
| CN113331815A (en) * | 2020-03-02 | 2021-09-03 | 哈尔滨医科大学 | Multi-core radio frequency coil transceiving and ultrasonic array unit synchronous control device and method |
| CN113552515A (en) * | 2021-06-29 | 2021-10-26 | 上海辰光医疗科技股份有限公司 | Dual-core imaging method for animal magnetic resonance imaging |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lerch et al. | Studying neuroanatomy using MRI | |
| Alexander et al. | Imaging brain microstructure with diffusion MRI: practicality and applications | |
| Dyrby et al. | Validation strategies for the interpretation of microstructure imaging using diffusion MRI | |
| Jelescu et al. | Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange | |
| Afzali et al. | The sensitivity of diffusion MRI to microstructural properties and experimental factors | |
| Hagmann et al. | MR connectomics: principles and challenges | |
| Mori et al. | Principles of diffusion tensor imaging and its applications to basic neuroscience research | |
| Jones | Studying connections in the living human brain with diffusion MRI | |
| Tuch et al. | Diffusion MRI of complex neural architecture | |
| Zhang et al. | Structural insights into the rodent CNS via diffusion tensor imaging | |
| Flint et al. | Cellular-level diffusion tensor microscopy and fiber tracking in mammalian nervous tissue with direct histological correlation | |
| Hansen et al. | Recent developments in fast kurtosis imaging | |
| Ma et al. | Three‐dimensional whole‐brain simultaneous T1, T2, and T1ρ quantification using MR multitasking: method and initial clinical experience in tissue characterization of multiple sclerosis | |
| WO2011130633A2 (en) | Simultaneous mapping of multiple chemicals with suppression of unwanted signals via molecular specific coherence (msc)-selmqc (selective multiple quantum coherence) | |
| Van et al. | An introduction to model-independent diffusion magnetic resonance imaging | |
| CN105842641A (en) | Multi-channel three-dimensional magnetic resonance imaging method based on 1H-19F-31P nucleus | |
| Taylor et al. | Patterns of intersecting fiber arrays revealed in whole muscle with generalized Q-space imaging | |
| Kiselev et al. | Toward quantification: Microstructure and magnetic resonance fingerprinting | |
| Emwas et al. | Theory and applications of NMR-based metabolomics in human disease diagnosis | |
| Giovannetti et al. | Sodium radiofrequency coils for magnetic resonance: From design to applications | |
| CN105785296A (en) | Multichannel three-dimensional nuclear magnetic resonance imaging method based on 1H-19F-23Na atomic nucleus | |
| Hoffman et al. | Assessing the multiscale architecture of muscular tissue with Q‐space magnetic resonance imaging | |
| Giovannetti et al. | Design and simulation of a dual-tuned 1 H/23 Na birdcage coil for MRS studies in human calf | |
| Melie-García et al. | A Bayesian framework to identify principal intravoxel diffusion profiles based on diffusion-weighted MR imaging | |
| Kundu et al. | Mapping the individual human cortex using multidimensional MRI and unsupervised learning |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Shen Baozhong Inventor after: Wu Lina Inventor after: Xiao Zunyu Inventor after: Zhang Ruixin Inventor after: Huang Tao Inventor after: Sun Xilin Inventor after: Wang Kai Inventor after: Wang Yingyi Inventor before: Shen Baozhong |
|
| COR | Change of bibliographic data | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160810 |
|
| RJ01 | Rejection of invention patent application after publication |