CN105837524B - A kind of synthetic method of 5- azepines cytimidine - Google Patents
A kind of synthetic method of 5- azepines cytimidine Download PDFInfo
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- CN105837524B CN105837524B CN201610271929.7A CN201610271929A CN105837524B CN 105837524 B CN105837524 B CN 105837524B CN 201610271929 A CN201610271929 A CN 201610271929A CN 105837524 B CN105837524 B CN 105837524B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
Abstract
The invention discloses a kind of synthetic methods of 5 azepine cytimidine, include the following steps：(1) dicyandiamide, formic acid and catalyst p-methyl benzenesulfonic acid are added into confined reaction device, milk is obtained after heating reaction；(2) 5 azepine cytimidines be can be obtained after the product obtained with hydrochloric acid purification step (1).The present invention is to utilize autoclave, under the conditions of Catalyzed by p-Toluenesulfonic Acid, significantly reduce the dehydration temperature of dicyandiamidines formates, directly using the anhydrous formic acid in system as dehydrating agent, the step of simplifying synthesis technology reduces the generation of side reaction, ensure that product to quality, yield is improved, reaction yield is higher than 80% in terms of dicyandiamide.
Description
Technical field
The invention belongs to organic synthesis field more particularly to a kind of synthetic methods of 5- azepines cytimidine.
Background technology
5- azepine cytimidines are the basic materials of chemical synthesis azasugar aminoglycoside.Using 5- azepines cytimidine as raw material
Medicine has 5-azacitidine, trade name Vidaza.Also decitabine, trade name
Decitabine.They belong to demethylation drug, the therapy mechanism with unique methylated transferase inhibitor.Its
Clinically for myelodysplastic syndrome, marrow chronic myeloid leukemia, sickle-cell anemia and in some entity tumors
In curative effect obtained the certification of U.S. FDA.
In past clinical practice, the effect of 5-azacitidine class drug and safety has obtained continuous verification,
Indication extends also with the development of various application studies, is gradually available for the treatment of a variety of different malignant tumours, achieves
Good therapeutic effect.With the rapid development of economy, the transformation of people's lives mode and the acceleration of aging of population process,
Cancer has become the non-communicable diseases for seriously affecting people's health that ranked second position after cardiovascular and cerebrovascular disease.Cause
The exploitation of the 5- azepine cytimidine synthesis technologies of this green low cost will be helpful to 5-azacitidine class drug and further face
Bed application study is carried out, while effectively reducing the cost of China's malignant tumor patient treatment.
The report about 5- azepine cytimidines is a kind of method that Orundmann et al. was reported in 1954 earliest
(Grundmann et al.Zur Kenntnis der Amino-triazine Chemische Berichte, 1954 (87),
19-23.)：After dicyandiamide and formic acid are directly mixed, after being reacted 3 hours under conditions of 130 DEG C in flask, obtain a large amount of
Pasty solid, be added ethyl alcohol washing, finally obtain 5- azepines cytimidine (chemical equation is as follows), the yield of this method is not
Foot 20%, and a large amount of dicyandiamide copolymers are generated during the reaction, it is difficult to separating-purifying.
Another scheme is that (PCT Patent, Bigatti, Ettore et are reacted with triethyl orthoformate using dicyandiamidines
Al, WO2010017374. United States Patent (USP), Bigatti, E.et al.；US201035354；Czech patents, Piskala, Alois
Et al.CZ269077), reflux acquisition 5- azepine cytimidines, the yield of this reaction can reach 28% in DMF.Guo Gang etc.
People (G.Guo, Synthesis and antiproliferative activities of 5-azacytidine analogs
In human leukemia cells, molecules, 13 (7), 2008,1487-1500) utilize trimethyl orthoformate for raw material
85% yield can be obtained.But unstable chemcial property has been used in reaction process and has been not belonging to the amidino groups of large marketable material
Urea is opposite to synthesize (chemical equation is as follows) with high costs.
(Niedballa U, the and Vobr H.A General Synthesis of N- such as Niedballa
glycosides V.Synthesis of 5-Azacytidines.Journal of Organic Chemistry,1974,
39,3762-3764.) 140 DEG C of reflux 2h in acetic anhydride using dicyanamide and formic acid as raw material, obtain 5- azepine cytimidines, yield
34.6% (chemical equation is as follows).This scheme has used three kinds of raw materials, follow-up byproduct to be difficult to recycle.
Vujjini(Vujjini,S.K.An Improved and Scalable Process for the
Synthesis of 5-Azacytidine:An Antineoplastic Drug,Organic Process Research&
Development, 17 (2), 2013,303-306, Zhang Wensheng etc., 5- azepine cytimidine synthesis technologies, Wuhan University Journal (reason
Learn version), 2003,49 (4), 454-456) et al. use two-step process, using dicyandiamide and formic acid as raw material, first reaction obtain in
Between product dicyandiamidines formates, dehydration after purification prepares 5- azepines cytimidine (chemical equation is as follows), and synthesis yield can reach
To 60%.
In recent years, as international whole Fine Chemical Industry is shifted to China, the medical material medicine industry development in China is fast
The yield of speed, domestic azacytidine class drug rises year by year.The technique used at present is substantially to be with dicyandiamide and formic acid
Raw material selects suitable solvent to carry out liquid phase synthesis.But the debirs and waste water generated during the reaction are more, and environment is dirty
It is big to contaminate pressure.Especially in its final products subtractive process use a large amount of alcohol, to process safety control and liquid waste processing all
Difficulty increases.Therefore green low emission is the main direction of studying of current such material medicine new technique for synthesizing exploitation.
Invention content
The purpose of the present invention is exactly to solve the above-mentioned problems, to provide a kind of synthetic method of 5- azepines cytimidine, it has
Feed intake simplicity, and side reaction is few, and production cost is low, can realize industrialized production advantage.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of synthetic method of 5- azepines cytimidine, includes the following steps：
(1) dicyandiamide, formic acid and catalyst p-methyl benzenesulfonic acid are added into confined reaction device, breast is obtained after heating reaction
Shape object；
(2) 5- azepine cytimidines be can be obtained after the product obtained with hydrochloric acid purification step (1).
Specific chemical equation is as follows：
It is preferred that：The step (1) carries out in autoclave.
It is preferred that：The mass ratio that feeds intake of the formic acid and dicyandiamide is (1-2)：(2-4), more preferable 3：5.
It is preferred that：The addition of the toluenesulfonic acid is the 0.1%-0.5% of dicyandiamide quality, more preferable 0.2%.
It is preferred that：The mass fraction of the formic acid is 98%-99.5%.
It is preferred that：Reaction condition in step (1)：Reaction temperature is 100-120 DEG C (more preferable：100 DEG C), the reaction time is
1-2 hours (more preferably：1.5 hours).
It is preferred that：The mass fraction of hydrochloric acid is 5% in the step (2), feed intake volume and the first in step (1) of the hydrochloric acid
Acid feeds intake volume ratio as (7-10):1 (more preferably：8:1), the temperature of the hot-air oven drying is 80-85 DEG C.
It is preferred that：The specific steps of the step (2)：The product that step (1) obtains is transferred in reaction kettle, dilute salt is added
Acid is heated to reflux to solution to become and clarify, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, filtrate is added ammonium hydroxide in crystallization kettle and adjusts
After pH, white crystal is precipitated, after centrifugation, can be obtained 5- azepine cytimidines through hot-air oven drying.
It is preferred that：The mass fraction of the ammonium hydroxide is 30%, adjusts pH to 5-7 (more preferable pH is 6).
It is preferred that the formic acid, dicyandiamide, p-methyl benzenesulfonic acid, hydrochloric acid, ammonium hydroxide are that chemistry is pure.
For the present invention using formic acid, dicyandiamide as raw material, p-methyl benzenesulfonic acid is catalyst, using high pressure reaction assembly, utilizes first
The heat generated in acid and dicyandiamide reaction process increases autoclave body pressure, reduces the reaction temperature of formic acid system, avoids double
The generation of the polymerization side reactions of cyanamide.Mother liquor can recycle, and realize the greenization of entire synthesis technology.
Formic acid reacts generation 5- azepines cytimidine with dicyandiamide and is divided into two steps from the angle of kinetics, is double first
Cyano aquation generates dicyandiamidines to cyanamide in acid condition, and then dicyandiamidines reacts life with the intermolecular dehydration cyclization of formic acid generation again
At 5- azepine cytimidines.The first step of reaction needs water as reactive material, and can be sloughed between second step formic acid and dicyandiamidines
The water of two molecules.If water is excessive in system, under strongly acidic conditions, cyano can further be hydrolyzed to carboxyl and make dicyandiamide
Ammonification is decomposed under the high temperature conditions.Therefore the co-catalysis agent present invention adds p-methyl benzenesulfonic acid as dehydration and hydrolysis, carries
The high efficiency of second condensation dehydration of reaction, the water participation first step dicyandiamide aquation for directly utilizing second step dehydration to generate,
The generation of the possible side reaction of system is avoided simultaneously.
Generally use two-step method is synthesized in the prior art, and formic acid prepares dicyandiamidines formates with dicyandiamide first, so
Dehydration obtains 5- azepine cytimidines under the conditions of dicyandiamidines formates is existing for the strong dehydrating agent such as high temperature or acetic anhydride afterwards.Wherein due to
Dicyandiamidines formates stability itself is insufficient, and cyan-hydrolysis byproduct is more, therefore final whole yield is relatively low.
Two-step reaction is combined into one by the present invention, on the one hand simplifies dosing procedure, improves production efficiency, on the other hand
Micro water causes after dicyandiamide aquation is dicyandiamidines in the anhydrous formic acid of addition, using anhydrous formic acid itself as dehydrating agent,
Dehydration production 5- azepine cytimidines under the conditions of Catalyzed by p-Toluenesulfonic Acid, the water of abjection further promotes dicyandiamide aquation, to water
Solution preocess play a dual role of promote plus protection, reduce production cost, reduce side reaction generate, improve reaction yield and
Product purity.
The invention has the advantages that
1, the present invention under the conditions of Catalyzed by p-Toluenesulfonic Acid, significantly reduces dicyandiamidines first to utilize autoclave
The dehydration temperature of hydrochlorate the step of simplifying synthesis technology, subtracts directly using the anhydrous formic acid in system as dehydrating agent
The generation for having lacked side reaction ensure that product to quality, improves yield, reaction yield is higher than 80% in terms of dicyandiamide.
2, the present invention is slightly excessive in anhydrous formic acid, can effectively improve dicyandiamide conversion yields, greatly
Ground reduces the production cost of 5- azepine cytimidines.
3, entire reaction carries out in closed reaction system, almost three-waste free discharge in production process, purifying technique mistake
The waste liquid that journey generates can isolate ammonium chloride by concentrating cooling.A small amount of efflux wastewater is easy to biochemical degradation processing.
Description of the drawings
Fig. 1 is the 1H NMR spectras of 1 synthetic product of the embodiment of the present invention；
Fig. 2 is the FTIR spectrograms of 1 synthetic product of the embodiment of the present invention；
Fig. 3 is the high-efficient liquid phase chromatogram of 1 synthetic product of the embodiment of the present invention, chromatographic condition：Detection wavelength 317nm, stream
Mutually pure methanol is moved, test sample purity is higher than 95%；
Fig. 4 is the high-efficient liquid phase chromatogram of 2 synthetic product of comparative example of the present invention, chromatographic condition：Detection wavelength 317nm, stream
Mutually pure methanol is moved, test sample purity is higher than 95%.
Specific implementation mode
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
Embodiment 1
(1) anhydrous formic acid (99.5%) 1.5Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene
Sulfonic acid catalyst (0.005Kg).In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 110 DEG C, reaction terminates
Afterwards, reaction temperature is slowly reduced to room temperature, obtains white solid.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.8kg through hot-air oven drying
(with dicyandiamide rate of collecting for 85%).
The product that it can be seen from Fig. 1 and Fig. 2 prepared by the present invention is 5- azepine cytimidines, is obtained by Fig. 3, by efficient
Liquid chromatogram can be seen that purity is higher than 95%.
Embodiment 2
(1) anhydrous formic acid (98%) 1.3Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene sulphur
Acid catalyst (0.005Kg).In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 100 DEG C, after reaction,
Reaction temperature is slowly reduced to room temperature, obtains white solid.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.65kg through hot-air oven drying
(with dicyandiamide rate of collecting for 80%).
It is obtained by Fig. 4, by high-efficient liquid phase chromatogram it can be seen that purity is higher than 95%.
Embodiment 3
(1) anhydrous formic acid (99.5%) 2.0Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene
Sulfonic acid catalyst (0.005Kg).In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 120 DEG C, reaction terminates
Afterwards, reaction temperature is slowly reduced to room temperature, obtains white solid.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.8kg through hot-air oven drying
(with dicyandiamide rate of collecting for 85%).
Embodiment 4
(1) anhydrous formic acid (99.5%) 1.5Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene
Sulfonic acid catalyst 0.0025Kg.In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 110 DEG C, after reaction,
Reaction temperature is slowly reduced to room temperature, obtains white solid.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 1.9kg through hot-air oven drying
(with dicyandiamide rate of collecting for 58%).
Embodiment 5
(1) anhydrous formic acid (99.5%) 1.5Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene
Sulfonic acid catalyst 0.01Kg.In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 110 DEG C, after reaction, delayed
The slow reaction temperature that reduces obtains white solid to room temperature.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.7kg through hot-air oven drying
(with dicyandiamide rate of collecting for 81%).
Embodiment 6
(1) anhydrous formic acid (99.5%) 1.5Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene
Sulfonic acid catalyst 0.005Kg.In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to reaction temperature, reaction terminates
Afterwards, reaction temperature is slowly reduced to room temperature, obtains white solid.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 5, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.4kg through hot-air oven drying
(with dicyandiamide rate of collecting for 72%).
Embodiment 7
(1) anhydrous formic acid (99.5%) 1.5Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene
Sulfonic acid catalyst 0.005Kg.In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 110 DEG C, after reaction,
Reaction temperature is slowly reduced to room temperature, obtains white solid.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 7, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.8kg through hot-air oven drying
(with dicyandiamide rate of collecting for 85%).
Embodiment 8
(1) anhydrous formic acid (98%) 1.5Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene sulphur
Acid catalyst 0.005Kg.In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 110 DEG C, after reaction, delayed
The slow reaction temperature that reduces obtains white solid to room temperature.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.4kg through hot-air oven drying
(with dicyandiamide rate of collecting for 72%).
Embodiment 9
(1) anhydrous formic acid (99.5%) 1.5Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene
Sulfonic acid catalyst (0.005Kg).In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 100 DEG C, reaction terminates
Afterwards, reaction temperature is slowly reduced to room temperature, obtains white solid.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.0kg through hot-air oven drying
(with dicyandiamide rate of collecting for 60%).
Embodiment 10
(1) anhydrous formic acid (99.5%) 1.5Kg, dicyandiamide 2.5Kg is sequentially added into 10L autoclaves and to toluene
Sulfonic acid catalyst (0.005Kg).In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 130 DEG C, reaction terminates
Afterwards, reaction temperature is slowly reduced to room temperature, obtains white solid.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 2.8kg through hot-air oven drying
(with dicyandiamide rate of collecting for 85%).
Contrast experiment 1
(1) anhydrous formic acid (98%) 1.5Kg, dicyandiamide 2.5Kg are sequentially added into 10L autoclaves, not plus are catalyzed
Agent.In the case where sealing stirring, reaction kettle is pressurizeed and is to slowly warm up to 130 DEG C, after reaction, slowly reduces reaction temperature
To room temperature, white solid is obtained.
(2) white solid is transferred in 50L glass reaction kettles, addition 10L mass concentrations are 5% dilute hydrochloric acid.Add
Heat reflux becomes for 30 minutes to solution clarifies, and by mixed liquor through filter cylinder heat filtering to crystallization kettle, 30% ammonia is added in crystallization kettle in filtrate
Water adjusts pH to 6, and white crystal is precipitated, and after centrifugation, can be obtained 5- azepine cytimidines 1.1kg through hot-air oven drying
(with dicyandiamide rate of collecting for 33%).
Contrast experiment 2
(1) 99.% anhydrous formic acid 100mL is added in 1000mL three-necked flasks, dicyandiamide 84g is then added portionwise, rises
Temperature to 118-120 DEG C react 3 hours, then in obtained thick white object be added 95% ethyl alcohol of 100ml, after stirring evenly
Precipitation is filtered out, is ground after drying, straticulation is spread out, is put into baking oven at 145 DEG C and toasts 2 hours, obtain white solid.
(2) crude product obtained in the previous step is added to the dilute hydrochloric acid of 300mL5% in 1000mL flasks, is heated to reflux, it is living
Property carbon decoloring processing after, filter while hot, a large amount of white crystals are precipitated with 30% aqueous ammonia conditions pH to 6. cooling and standings in filtrate.
Filtering, washing, obtains 60.3g 5- azepines cytimidine after drying (with dicyandiamide rate of collecting 54%).
The result shows that：Technical solution synthesis 5- azepines cytimidine using the present invention is substantially better than in comprehensive yield and cost
The production technology of existing document report.Embodiment illustrates that the core of technical solution of the present invention is toluene compared with comparative example
The use of sulfonic acid catalyst, significantly reduces the dehydration temperature of dicyandiamidines formates, directly utilizes anhydrous in system
Formic acid is as dehydrating agent so that the hydration reaction of dicyandiamide and the dehydration of dicyandiamidines formates can assist under hydrothermal conditions
With progress.The step of simplifying synthesis technology reduces the generation of side reaction, ensure that product to quality, improves yield, instead
Yield is answered to be higher than 80% in terms of dicyandiamide.
Above-mentioned, although the foregoing specific embodiments of the present invention is described with reference to the accompanying drawings, not protects model to the present invention
The limitation enclosed, those skilled in the art should understand that, based on the technical solutions of the present invention, those skilled in the art are not
Need to make the creative labor the various modifications or changes that can be made still within protection scope of the present invention.
Claims (6)
1. a kind of synthetic method of 5- azepines cytimidine, it is characterized in that：Include the following steps：
(1) dicyandiamide, formic acid and catalyst p-methyl benzenesulfonic acid are added into confined reaction device, emulsus is obtained after heating reaction
Object；
(2) 5- azepine cytimidines be can be obtained after the product obtained with hydrochloric acid purification step (1)；
The step (1) carries out in autoclave；
The mass fraction of the formic acid is 98%-99.5%；
The addition of the p-methyl benzenesulfonic acid is the 0.1%-0.5% of dicyandiamide quality；
The specific steps of the step (2)：The product that step (1) obtains is transferred in reaction kettle, dilute hydrochloric acid is added, heats back
It flow to solution and becomes clarification, by mixed liquor through filter cylinder heat filtering to crystallization kettle, filtrate is precipitated after ammonium hydroxide adjusting pH is added in crystallization kettle
White crystal after centrifugation, can be obtained 5- azepine cytimidines through hot-air oven drying.
2. synthetic method as described in claim 1, it is characterized in that：The mass ratio that feeds intake of the formic acid and dicyandiamide is (1-2):
(2-4)。
3. synthetic method as described in claim 1, it is characterized in that：Reaction condition in step (1)：Reaction temperature is 100-
120 DEG C, the reaction time is 1-2 hours.
4. synthetic method as described in claim 1, it is characterized in that：The mass fraction of hydrochloric acid is 5% in the step (2).
5. synthetic method as described in claim 1, it is characterized in that：The volume that feeds intake of the hydrochloric acid is thrown with formic acid in step (1)
Expect that volume ratio is (7-10):1.
6. synthetic method as described in claim 1, it is characterized in that：The mass fraction of the ammonium hydroxide is 30%.
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