CN105832873B - 一种润肺、止咳的牛大力组合物及其制备方法和应用 - Google Patents
一种润肺、止咳的牛大力组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明涉及保健品领域,公开了一种润肺、止咳的牛大力组合物及其制备方法和应用。本发明所述的润肺、止咳组合物包括以下组分:牛大力,诃子,鱼腥草,陈皮,白术,紫苑花,栀子花。本发明同时公开了其制备方法。本发明所述的润肺、止咳的牛大力组合物,各种药材药效相互补充、互相促进,达到标本兼治的目的。本发明提供的制备方法,简便易行,所制的成品便于保存。上述组合物可用于制备具有润肺止咳作用的制剂,疗效显著。
Description
技术领域
本发明涉及保健品领域,特别是指一种润肺、止咳的牛大力组合物及其制备方法和应用。
背景技术
随着环境不断恶化,空气污染加剧,空气中的有害气体以及悬浮颗粒不断增加,刺激呼吸道以及肺,导致各种呼吸系统疾病的发病率不断增加。尤其是进入秋冬季节,由于降水的减少,空气中的悬浮物大量增加,刺激呼吸系统,咽喉肿痛、咳嗽、胸痛、哮喘等呼吸系统疾病更是频繁发生,严重影响了人们工作和日常生活。
牛大力,别名猪脚笠、金钟根、山莲藕、倒吊金钟、大力薯。为豆科豆科崖豆藤属植物美丽崖豆藤MillettiaspecisoaChamp.。牛大力以根入药,其性甘、平,归肺、肾经,是一种常用的中草药,广东、广西等地经常用来煲汤。现代药物化学研究证明,其根中含有多种黄酮类化合物,已确定结构有:蔓性千斤拔素(flemiphilippinin)C、D。此外还含5,7,3',4'-四羟基-6,8-双异戊烯基异黄酮(5,7,3',4'-tetrahydroxy-6,8-diprenylisoflavone),千斤拔素(flemichin)D,羽扇豆醇(lupeol),β-谷甾醇(β-sitosterol)以及碳原子数为22-30的正烷酸。此外,还含有蛋白质、淀粉质及生物碱等。
发明内容
本发明提出了一种润肺、止咳的牛大力组合物及其制备方法,可以滋养肺阴、缓解咽喉不适感,具有显著的润肺及止咳的功效。
本发明的技术方案是这样实现的:
一种润肺、止咳的牛大力组合物,包括以下组分:牛大力、诃子、鱼腥草、陈皮、白术、紫苑花和栀子花。
进一步,上述润肺、止咳的牛大力组合物各组分的重量份数为:牛大力20-50份,诃子12-30份,鱼腥草10-30份,陈皮5-20份,白术1-20份,紫苑花1-20份,栀子花1-20份。
一种润肺、止咳的药物,为以上所述的牛大力组合物的水提物。
一种润肺、止咳的药物的制备方法,包括以下步骤:取以上所述的牛大力组合物加水煎煮,取水提物,浓缩干燥,即得。
进一步,上述制备方法包括以下步骤:取上述牛大力组合物中的牛大力、诃子、鱼腥草、陈皮和白术,清洗后烘干、粉碎,加水,煎煮20-30min后,加入权利要求1或2所述的牛大力组合物中的紫苑花和栀子花,继续煎煮20-30min,过滤除去药渣得滤液;药渣重复煎煮2-3次,合并滤液,干燥即得本发明所述的润肺、止咳的牛大力组合物。
进一步,牛大力、诃子、鱼腥草、陈皮和白术烘干过程中控制温度60-80℃,粉碎至粒径30-50目;水的加入量为所有药材总质量的5-10倍;滤液干燥采用喷雾干燥或者冷冻干燥的方法。
以上所述的润肺止咳的牛大力组合物、或润肺止咳的药物、或采用上述制备方法制备的润肺止咳的药物在制备润肺、止咳的制剂方面的应用。
一种润肺、止咳的制剂,包含上述润肺止咳的组合物、或润肺止咳的药物、或采用上述制备方法制备的润肺止咳的药物。
进一步,所述的制剂为袋泡茶、速溶茶、胶囊剂、片剂、颗粒剂、或糖浆。
本发明的有益效果:
牛大力归肺、肾经,具有补虚润肺,强筋活络之功效。常用于治疗肺热、肺虚咳嗽、肺结核等,尤其适用于经常咳嗽或者患有急慢性支气管炎及吸烟和吸入厨房油烟人士。
诃子味苦,酸,涩,性平;具有敛肺止咳、降火利咽之功效,多用于肺虚喘咳,久嗽不止,咽痛音哑。
鱼腥草味辛,性寒凉,归肺经,具有清热解毒、化痰排脓、健胃消食之功效,常用于治疗肺痈吐脓、痰热喘咳。
陈皮性温,味辛、味苦,入脾经、胃经、肺经;具有理气健脾、调中化痰之功效,对于痰湿壅肺之咳嗽气喘,胸脘胀满,食少吐泻,咳嗽痰多具有较好的治疗效果。
白术苦、甘,温,归脾、胃经;具有健脾益气、燥湿利水的功效,用于脾虚食少、腹胀泄泻、痰饮眩悸,能够除胃热,强脾胃,进饮食,和胃。
紫苑花苦、甘,微温。归肺经,具有润肺下气、消痰止咳的功效,对于痰多喘咳,新久咳嗽,劳嗽咳血均有较好的疗效。
栀子花性寒味甘苦入肺、肝经,具有清肺止咳、凉血止血的功效,对肺热咳嗽、鼻咯、痰肿毒等病症均有疗效。
本发明所述的润肺、止咳的牛大力组合物,以传统中医理论为基础,选择不同功效的药材搭配使用,其药效相互补充、互相促进,具有补肺虚、润肺燥、化痰止咳的多重功效。牛大力、诃子、鱼腥草、紫苑花和栀子花配合使用,具有显著的润肺、止咳的效果,可以清虚热,有利于恢复机体内的阴阳平衡。而白术和陈皮可以调理机体内的气机,增强脾胃功能,提高机体运化水谷的能力,从而增强体质,提高机体自身的免疫力。上述药材通过组方配伍,其作用互相协调,具有相益相加的效果,在外可以化痰止咳,消除疾病症状,在内可以补肺虚、润肺燥、清虚热,平衡阴阳,全面调理肺脏功能,达到标本兼治的效果。此外,本发明所述的组合物还可以调理脏腑气机,增强脾胃功能,增强机体体质,从而增强呼吸系统自身的防御能力,提高和巩固药效。而肺脏阴阳平衡的恢复和调理,又有有助于脏腑平衡的恢复,有助于机体气机的通畅。通过本发明提供的制备方法,简便易行,所制的成品便于保存,并可以添加一定的辅料制成多种剂型,如袋泡茶、速溶茶、胶囊剂、片剂、颗粒剂或糖浆等,服用方便,疗效显著。
具体实施方式
下面将结合本发明实施例,对本发明中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种润肺、止咳的牛大力组合物,包括以下重量份数的组分:牛大力20g,诃子10g,鱼腥草10g,陈皮5g,白术1g,紫苑花1g,栀子花1g。
一种润肺、止咳组合的制备方法,包括以下步骤:
(1)取配方量的牛大力、诃子、鱼腥草、陈皮和白术,清洗后60℃烘干,粉碎至粒径30目,加水,煎煮20min后,加入配方量的紫苑花和栀子花,继续煎煮20min,过滤除去药渣得滤液;重复2g次,合并滤液;水的加入量为所有药材总质量的5g倍;
(2)将步骤(1)所得的滤液喷雾干燥即得本发明所述的润肺、止咳的牛大力组合物。
实施例2
一种润肺、止咳的牛大力组合物,包括以下重量份数的组分:牛大力50g,诃子30g,鱼腥草30g,陈皮20g,白术20g,紫苑花20g,栀子花20g。
一种润肺、止咳组合的制备方法,包括以下步骤:
(1)取配方量的牛大力、诃子、鱼腥草、陈皮和白术,清洗后80℃烘干,粉碎至粒径50目,加水,煎煮30min后,加入配方量的紫苑花和栀子花,继续煎煮30min,过滤除去药渣得滤液;重复3次,合并滤液;水的加入量为所有药材总质量的10倍;
(2)将步骤(1)所得的滤液冷冻干燥即得本发明所述的润肺、止咳的牛大力组合物。
实施例3
一种润肺、止咳的牛大力组合物,包括以下重量份数的组分:牛大力30g,诃子15g,鱼腥草20g,陈皮15g,白术10g,紫苑花10g,栀子花10g。
一种润肺、止咳组合的制备方法,包括以下步骤:
(1)取配方量的牛大力、诃子、鱼腥草、陈皮和白术,清洗后70℃烘干,粉碎至粒径40目,加水,煎煮25min后,加入配方量的紫苑花和栀子花,继续煎煮25min,过滤除去药渣得滤液;重复3次,合并滤液;水的加入量为所有药材总质量的8倍;
(2)将步骤(1)所得的滤液喷雾干燥即得本发明所述的润肺、止咳的牛大力组合物。
实施例4
一种润肺、止咳的袋泡茶,包括以下重量份数的组分:牛大力40g,诃子15g,鱼腥草15g,陈皮10g,白术15g,紫苑花15g,栀子花15g。制备方法如下:取上述药材,清洗后烘干,粉碎至30-50目,消毒装袋即得所述的润肺、止咳的袋泡茶。
实施例5
一种润肺、止咳的速溶茶,制备方法如下:取实施例1-3任一项制得的润肺、止咳的牛大力组合物,粉碎,加入糖粉、麦芽糊精,以重量份数计,牛大力组合物10份,糖粉20份,麦芽糊精10份;混合均匀,过150目筛,即得所述的润肺、止咳的速溶茶。
实施例6
一种润肺、止咳的胶囊剂,制备方法如下:取实施例1-3任一项制得的润肺、止咳的牛大力组合物,粉碎过70目筛,加入玉米淀粉,以重量份数计,牛大力组合物10份,玉米淀粉30份;混合均匀,灌装,即得所述的胶囊剂。
实施例7
一种润肺、止咳的片剂,制备方法如下:取实施例1-3任一项制得的润肺、止咳的牛大力组合物,粉碎过100目筛,加入糖粉和矫味剂,以重量份数计,牛大力组合物10份,糖粉20份,矫味剂1份,混合均匀,压片,即得所得的片剂。
实施例8
一种润肺、止咳的颗粒剂,制备方法如下:取实施例1-3任一项制得的润肺、止咳的牛大力组合物,粉碎过100目筛,加入糖粉、糊精,以重量份数计,牛大力组合物10份,糖粉10份,麦芽糊精10份;加水混合制成软才,喷雾干燥即得所述的颗粒剂。
实施例9
一种润肺、止咳的糖浆剂,制备方法如下:取取实施例1-3任一项制得的润肺、止咳的牛大力组合物,粉碎,加入少量甘油研磨均匀,加入单糖浆,以重量份数计,牛大力组合物10份,单糖浆30份,混匀过滤除去不容物,即得所述的糖浆剂。
本发明所述的组合物止咳效果考察
NIH小鼠80只,体重18-22g,雌雄各半,实验前禁食12h,随机分为8组,实验组按以下配比给药,给药剂量按25g/kg,灌胃给药;药物对照组给予咳必清,空白对照组给予生理盐水,对照组和空白对照组按25mL/kg灌胃给药。以上小鼠给药1h后,单个置于容积为1L的密闭玻璃罩内,用超声雾化装置从底部持续喷入25%的氨水20秒,取出记录咳嗽潜伏期及5min内咳嗽次数,每组数据取其平均值,其实验结果如表1所示。
实验组1:给予实施例1所制得的润肺、止咳组合物;
实验组2:给予实施例2所制得的润肺、止咳组合物;
实验组3:给予实施例3所制得的润肺、止咳组合物;
实验组4:实施例2的组方中去掉诃子和鱼腥草,其余与实施例2相同;
实验组5:实施例2的组方中去掉牛白术和陈皮,其余与实施例2相同;
实验组6:实施例2的组方中去掉紫苑花和栀子花,其余与实施例2相同;
表1本发明所述的组合物止咳组合物效果考察
由表1可以看出,本发明3个实施例所制得的润肺、止咳组合物可以显著延长咳嗽潜伏期,减少咳嗽次数,其作用效果与空白对照组相比有显著差异。与咳必清相比,其咳嗽潜伏期明显延长,实验组2作用效果尤其显著;而咳嗽次数相差不大。说明本发明3个实施例制得的润肺、止咳组合物具有很好的止咳效果。同时,由表1还可以看出,实验组4-6的咳嗽潜伏期和咳嗽次数虽然比空白对照组均有一定程度的改善,但是其作用效果明显低于实验组1-3,存在显著的差异。说明本发明所述的润肺、止咳组合物,其组方中的药材通过配伍,药效相互促进、相互补充,具有明显的协同增效的作用,去掉其中的一种或者两者都无法达到完整组方的作用效果。
本发明所述的组合物人体试食实验
患者黄某某,女,56岁,症状:咳嗽,咽喉干痒、红肿,胸闷;服用本发明实施例5所制得的润肺、止咳速溶茶,一日3次,连用7天。上述症状均消失。
患者李某,男,23岁,症状:喉咙发炎,干咳无痰,有轻微的盗汗的症状;服用本发明实施例4润肺、止咳袋泡茶,一日3次,连用10天,喉咙发炎,干咳症状消失,盗汗症状有明显改善。
患者王某某,女,67岁,症状:有哮喘病史,咳喘气短,晚上睡眠质量差,疲倦乏力,抵抗力差;服用本发明实施例4所制得的润肺、止咳袋泡茶,一日3次,连用3个月,疲倦乏力症状明显改善,睡眠质量显著提高,哮喘发作次数明显减少,咳喘气短现象有所减轻。
患者胡某,男,55岁,症状:舌红口干,干咳少痰,失眠;服用本发明实施例7所制得润肺、止咳片剂,一日2次,连用1个月,舌红口干、干咳少痰症状完全消失,失眠症状有明显改善,精神状态明显好转。
患者黄某,女,19岁,症状:喉咙肿痛,咳嗽,有清痰,食欲不振;服用本发明实施例9所得的润肺、止咳糖浆剂,一日3次,3天后喉咙肿痛症状消失,7天后上述症状基本消失。
患者李某某,女,35岁,症状:声音嘶哑,咽痛,有浓痰,胸闷;服用本发明实施例8所制得的颗粒剂,一日3次,连用5天,上述症状全部消失。
患者张某,男,20岁,症状:舌红,口干,咽痛,干咳,精神不振,乏力,有轻微失眠症状。服用本发明实施例6所制得的胶囊剂,一日3次,连用一周,口干、咽痛、干咳症状均有明显改善,10天后症状消失,失眠、乏力症状明显改善,精神专利明显好转。
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (5)
1.一种润肺、止咳的药物的制备方法,其特征在于,包括以下步骤:取牛大力组合物中的牛大力、诃子、鱼腥草、陈皮和白术,清洗后烘干、粉碎,加水,煎煮20-30min后,加入牛大力组合物中的紫苑花和栀子花,继续煎煮20-30min,过滤除去药渣得滤液;药渣重复煎煮2-3次,合并滤液,干燥即得润肺、止咳的药物;所述的牛大力组合物,包括以下重量份数的组分:牛大力20-50份,诃子12-30份,鱼腥草10-30份,陈皮5-20份,白术1-20份,紫苑花1-20份,栀子花1-20份。
2.如权利要求1所述的一种润肺、止咳的药物的制备方法,其特征在于:牛大力、诃子、鱼腥草、陈皮和白术烘干过程中控制温度60-80℃,粉碎至粒径30-50目;水的加入量为所有药材总质量的5-10倍;滤液干燥采用喷雾干燥或者冷冻干燥的方法。
3.如权利要求1或2所述润肺、止咳的药物的制备方法制备的润肺止咳的药物在制备润肺、止咳的制剂方面的应用。
4.一种润肺、止咳的制剂,其特征在于:包含权利要求1-3中任意一项所述制备方法制备的润肺、止咳的药物。
5.如权利要求4所述的一种润肺、止咳的制剂,其特征在于:所述的制剂为袋泡茶、速溶茶、胶囊剂、片剂、颗粒剂、或糖浆。
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