CN105832651A - 具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放 - Google Patents
具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放 Download PDFInfo
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Abstract
本发明涉及一种具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放,该方法包括以下步骤:配制阿司匹林掺杂聚吡咯/蒙脱土的聚合液、制备阿司匹林掺杂聚吡咯/蒙脱土复合材料以及不同电位条件下的药物体外释放。本发明的有益效果:聚吡咯/蒙脱土复合材料具有电刺激敏感性的药物释放行为,可以电调控药物的释放,且材料的制备方法简便易行,其延缓了药物的释放,使药效在体内维持较长的时间。
Description
技术领域
本发明涉及一种具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放,属于材料合成和生物医药领域。
技术背景
在过去的几十年中,具有电刺激响应特征的智能型药物缓释系统已经引起了科研工作者极大的兴趣。最近,导电高分子作为基体材料广泛地应用于药物缓释系统,其引起了人们的关注。在众多的导电高分子中,因为聚吡咯具有可逆的氧化还原性能和良好的生物相容性,它已经成为了优良的药物载体材料。然而,导电高分子较小的比表面积限制了其对药物的负载能力,阻碍了其在药物缓释领域的应用。
为了提高药物缓释系统对药物的负载能力,通过增加基体材料的比表面积来提高材料对药物的负载能力。蒙脱土不仅表现出良好的稳定性能,而且具有较高的吸附能力和较大的比表面积。这些优点使蒙脱土成为药物缓释系统的理想载体材料。综上所述,研究合成聚吡咯/蒙脱土复合材料以及将其应用于电刺激药物的释放有着巨大的意义。本发明利用电化学氧化法原位聚合吡咯的技术,合成了蒙脱土修饰的聚吡咯复合材料。该复合材料结合了聚吡咯和蒙脱土的各自优点,较为方便地制备了一种具有电刺激响应的聚吡咯/蒙脱土复合材料,并将其应用于电调控药物的释放。
发明内容
本发明的目的在于提供一种具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放。阿司匹林作为药物模型和阴离子掺杂剂,掺杂到聚吡咯的骨架中和插入到蒙脱土的层间。获得优异电学性能的聚吡咯/蒙脱土复合材料,拓宽了蒙脱土在生物医药领域的应用范围。本发明利用聚吡咯对电刺激具有敏感性和蒙脱土具有较大比表面积的特点,制备了具有对电刺激敏感药物缓释材料。
本发明所述一种具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放,包括以下步骤:
a、配制阿司匹林掺杂聚吡咯/蒙脱土的聚合液:称取0.06~0.08g的阿司匹林溶于25mL的磷酸盐缓冲溶液(PBS)中,随后将0.5~0.7g的蒙脱土分散于上述溶液中。将含有阿司匹林和蒙脱土的PBS超声分散1h后,加入0.3~0.5mL的吡咯单体并磁力搅拌10~40min。在电化学聚合之前,向溶液中通氮气10~30min,以除去溶液中的氧气;
b、制备阿司匹林掺杂聚吡咯/蒙脱土复合材料:将处理好的导电玻璃(1cm×3cm)电极浸到步骤a配制的聚合液中,施加0.6~0.8V的电位使吡咯发生聚合,聚合时间为300~600s。随后,用去离子水彻底冲洗制备完成的阿司匹林掺杂聚吡咯/蒙脱土复合材料,室温干燥;
c、不同电位条件下的药物体外释放:配制磷酸盐缓冲溶液(PBS)用于模拟人体环境,并恒温释放,在25mL PBS中,对步骤b制备的复合材料施加-0.6~-0.8V的电位,通过电刺激触发阿司匹林的释放,每隔一定的时间,从溶液中吸取一定体积的溶液,通过测定阿司匹林在223nm处的吸光度,并结合郎伯-比尔定律计算阿司匹林的释放量,同时往溶液中补充相同体积的PBS。作为对比实验,在不施加电位的条件下进行阿司匹林的自然释放。
进一步地,步骤a中掺杂的药物阿司匹林也可以为水杨酸、紫杉醇、喜树碱、阿霉素、甲氨蝶呤、依托泊苷等阴离子或阳离子药物。
进一步地,步骤a中的磷酸盐缓冲溶液由磷酸氢二钠和磷酸二氢钠配制而成,浓度为0.1mol/L,pH为3.5~7.5。
进一步地,步骤c中的磷酸盐缓冲溶液由磷酸氢二钠和磷酸二氢钠配制而成,浓度为0.1mol/L,pH为3.4~11.4。
进一步地,步骤c中模拟人体环境,并恒温释放,其温度为36.5℃~37.5℃。
本发明的有益效果:聚吡咯/蒙脱土复合材料具有电刺激响应的药物释放行为,可以电调控药物的释放,且材料的制备方法简便易行,其延缓了药物的释放,使药效在体内维持较长时间。
附图说明
下面结合附图对本发明进一步说明。
图1为实施例一中蒙脱土的扫描电子显微镜照片;
图2为实施例一中制备的水杨酸掺杂聚吡咯/蒙脱土复合材料的扫描电子显微镜照片;
图3为实施例二中不同电位条件下水杨酸掺杂聚吡咯/蒙脱土复合材料的药物缓释性能图;
图4为对比例二中相同电场条件下水杨酸掺杂聚吡咯/蒙脱土复合材料和水杨酸掺杂聚吡咯材料的药物缓释性能图。
具体实施方式
现在结合具体实施例对本发明做进一步说明,以下实施例旨在说明本发明而不是对本发明的进一步限定。
实施例一:
制备具有电刺激响应的聚吡咯/蒙脱土复合材料包括以下几个步骤:
(1)称取0.075g的阿司匹林溶于25mL的磷酸盐缓冲溶液(PBS,pH 3.5)中,随后将0.56g的蒙脱土分散于上述溶液中。将含有阿司匹林和蒙脱土的PBS超声分散1h后,加入0.34mL的吡咯单体并磁力搅拌30min。在电化学聚合之前,向溶液中通氮气10min,以除去溶液中的氧气;
(2)将处理好的导电玻璃(1cm×3cm)电极浸到步骤(1)配制的聚合液中,施加0.8V的电位使吡咯发生聚合,聚合时间为500s。随后,用去离子水彻底冲洗制备完成的阿司匹林掺杂聚吡咯/蒙脱土复合材料,室温干燥。由于蒙脱土层间的范德华力、静电作用等,其为层状结构,如图1所示。复合材料的电镜图(图2)显示出花椰菜形状的聚吡咯涂覆在蒙脱土表面,结果表明我们成功地合成了聚吡咯/蒙脱土复合材料。
对比例一:
制备具有电刺激响应的聚吡咯材料包括以下几个步骤:
(1)称取0.075g的阿司匹林溶于25mL的磷酸盐缓冲溶液(PBS,pH 3.5)中,将含有阿司匹林的PBS超声分散1h后,加入0.34mL的吡咯单体并磁力搅拌30min。在电化学聚合之前,向溶液中通氮气10min,以除去溶液中的氧气;
(2)将处理好的导电玻璃(1cm×3cm)电极浸到步骤(1)配制的聚合液中,施加0.8V的电位使吡咯发生聚合,聚合时间为500s。随后,用去离子水彻底冲洗制备完成的阿司匹林掺杂聚吡咯材料,室温干燥。
实施例二:
不同电位条件下药物的体外释放包括以下几个步骤:
水杨酸掺杂聚吡咯/蒙脱土复合材料的制备过程与实施例一相同。
配制磷酸盐缓冲溶液(PBS,pH 7.4)用于模拟人体环境,并恒温释放,在25mL PBS(pH7.4)中,对水杨酸掺杂聚吡咯/蒙脱土复合材料施加-0.6V的电位,通过电刺激触发阿司匹林的释放,每隔一定的时间,从溶液中吸取一定体积的溶液,通过测定阿司匹林在223nm处的吸光度,并结合郎伯-比尔定律计算阿司匹林的释放量,同时往溶液中补充相同体积的PBS。作为对比实验,在不施加电位的条件下进行阿司匹林的自然释放。如图3所示,载药复合材料的累积释药量高达70.4μg/mL,而自然释放的累积释放药量只有32.8μg/mL。结果表明,通过施加外部电刺激可以控制阿司匹林的释放,此材料具有电调控药物释放的能力。
对比例二:
相同电位条件下不同材料的药物体外释放包括以下几个步骤:
水杨酸掺杂聚吡咯/蒙脱土复合材料的制备过程与实施例一相同,水杨酸掺杂聚吡咯材料的制备过程与对比例一相同。
配制磷酸盐缓冲溶液(PBS,pH 7.4)用于模拟人体环境,并恒温释放,在25mL PBS(pH7.4)中,分别对水杨酸掺杂聚吡咯/蒙脱土复合材料和水杨酸掺杂聚吡咯材料施加-0.6V的电位,通过电刺激触发阿司匹林的释放,每隔一定的时间,从溶液中吸取一定体积的溶液,通过测定阿司匹林在223nm处的吸光度,并结合郎伯-比尔定律计算阿司匹林的释放量,同时往溶液中补充相同体积的PBS。如图4所示,载药聚吡咯的累积释药量只有57.3μg/mL,与载药复合材料的累积释药量(70.4μg/mL)相比,释药量降低。结果表明,蒙脱土提高了缓释系统对药物的负载能力,又提高了药物的释放效率。
Claims (5)
1.一种具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放,其特征在于:步骤如下:
a、配制阿司匹林掺杂聚吡咯/蒙脱土的聚合液:称取0.06~0.08g的阿司匹林溶于25mL的磷酸盐缓冲溶液(PBS)中,随后将0.5~0.7g的蒙脱土分散于上述溶液中。将含有阿司匹林和蒙脱土的PBS超声分散1h后,加入0.3~0.5mL的吡咯单体并磁力搅拌10~40min。在电化学聚合之前,向溶液中通氮气10~30min,以除去溶液中的氧气;
b、制备阿司匹林掺杂聚吡咯/蒙脱土复合材料:将处理好的导电玻璃(1cm×3cm)电极浸入到步骤a配制的聚合液中,施加0.6~0.8V的电位使吡咯发生聚合,聚合时间为300~600s。随后,用去离子水彻底冲洗制备完成的阿司匹林掺杂聚吡咯/蒙脱土复合材料,室温干燥;
c、不同电位条件下的药物体外释放:配制磷酸盐缓冲溶液(PBS)用于模拟人体环境,并恒温释放,在25mL PBS中,对步骤b制备的复合材料施加-0.6~-0.8V的电位,通过电刺激触发阿司匹林的释放,每隔一定的时间,从溶液中吸取一定体积的溶液,通过测定阿司匹林在223nm处的吸光度,并结合郎伯-比尔定律计算阿司匹林的释放量,同时往溶液中补充相同体积的PBS。作为对比实验,在不施加电位的条件下进行阿司匹林的自然释放。
2.根据权利要求1所述具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放,其特征在于:所述步骤a中掺杂的药物阿司匹林也可以为水杨酸、紫杉醇、喜树碱、阿霉素、甲氨蝶呤、依托泊苷等阴离子或阳离子药物。
3.根据权利要求1所述具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放,其特征在于:所述步骤a中的磷酸盐缓冲溶液由磷酸氢二钠和磷酸二氢钠配制而成,浓度为0.1mol/L,pH为3.5~7.5。
4.根据权利要求1所述具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放,其特征在于:所述步骤c中的磷酸盐缓冲溶液由磷酸氢二钠和磷酸二氢钠配制而成,浓度为0.1mol/L,pH为3.4~11.4。
5.根据权利要求1所述具有电刺激响应的聚吡咯/蒙脱土复合材料的制备及其应用于电调控药物的释放,其特征在于:所述步骤c中模拟人体环境,并恒温释放,其温度为36.5℃~37.5℃。
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CN110201296A (zh) * | 2019-05-20 | 2019-09-06 | 北京化工大学 | 一种用于可控药物释放的导电高分子微针贴片及其制备方法 |
CN114561118A (zh) * | 2022-03-31 | 2022-05-31 | 哈尔滨工程大学 | 一种聚吡咯包裹石墨烯缓蚀剂容器及其制备方法和一种复合涂料及其应用 |
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CN110201296A (zh) * | 2019-05-20 | 2019-09-06 | 北京化工大学 | 一种用于可控药物释放的导电高分子微针贴片及其制备方法 |
CN114561118A (zh) * | 2022-03-31 | 2022-05-31 | 哈尔滨工程大学 | 一种聚吡咯包裹石墨烯缓蚀剂容器及其制备方法和一种复合涂料及其应用 |
CN114561118B (zh) * | 2022-03-31 | 2022-11-29 | 哈尔滨工程大学 | 一种聚吡咯包裹石墨烯缓蚀剂容器及其制备方法和一种复合涂料及其应用 |
US11795330B1 (en) | 2022-03-31 | 2023-10-24 | Harbin Engineering University | Polypyrrole encapsulated graphene corrosion inhibitor container and its preparation method and composite coating and its application |
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