CN105816502B - Three-cavity bag-packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof - Google Patents
Three-cavity bag-packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof Download PDFInfo
- Publication number
- CN105816502B CN105816502B CN201510000508.6A CN201510000508A CN105816502B CN 105816502 B CN105816502 B CN 105816502B CN 201510000508 A CN201510000508 A CN 201510000508A CN 105816502 B CN105816502 B CN 105816502B
- Authority
- CN
- China
- Prior art keywords
- injection
- bag
- amino acid
- glucose
- olive oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention relates to a three-cavity bag-packaged olive oil fat emulsion, amino acid and glucose injection pharmaceutical composition and a preparation method thereof, belonging to the technical field of medicines. The three-cavity bag adopts three cavities separated at intervals to respectively contain the olive oil fat emulsion injection, the compound amino acid injection and the glucose injection, and the components in each compartment can be mixed together by extruding the three-cavity bag before clinical infusion, so that the three-cavity bag is convenient to use, has no special requirement on environment, and avoids the risk of microorganism and particle pollution easily caused by the traditional mixing operation method.
Description
Technical Field
The invention relates to a three-cavity bag-packaged olive oil fat emulsion, compound amino acid and glucose injection pharmaceutical composition and a preparation method thereof, belonging to the technical field of medicines.
Background
Fat, protein and sugar are three basic nutrients which are needed by the human body in the largest quantity, and when the gastrointestinal tract of the human body is not fully functional or can not sufficiently absorb the nutrients, the three basic nutrients are required to be provided in an intravenous infusion way. Therefore, fat emulsion injection, compound amino acid injection and glucose injection are widely used in clinical practice to provide fat, protein and sugar, respectively, which is so-called parenteral nutrition.
Theories and practices prove that when long-term parenteral nutrition is needed, fat emulsion, amino acid and glucose are infused into veins of a human body, so that the requirement of physiological metabolism of the human body is met, and the method has very important significance for maintaining the balance of various nutrients in the human body and normal physiological functions of the human body.
In clinical practice, the fat emulsion injection, the compound amino acid injection and the glucose injection are simultaneously infused into a human body through a mixing pipeline before use, and the three products are infused into a specially designed sterile plastic bag through an infusion port of the sterile plastic bag after mixing. Because the whole mixing process is manually operated, the sealing of the product is damaged by multiple puncture actions, and the product is easily polluted by microorganisms due to slight error, so that serious consequences such as transfusion reaction, blood infection, septicemia and the like are brought to a patient; in addition, the rubber plug is punctured for many times, rubber plug particles are inevitably generated, and capillary vessels are easily blocked after the rubber plug particles enter blood, so that microcirculation embolism is caused.
CN101015501A discloses a composition of soybean oil fat emulsion, amino acid and glucose injection packed in three-cavity bag and its preparation method, adopting three cavities separated by diaphragm to respectively fill in the fat emulsion injection, compound amino acid injection and glucose injection, when in use, the three injections can be mixed uniformly by pressing each cavity forcibly in turn or tearing the separation strip between each cavity, thus the three injections can be infused into human body vein.
Similarly, CN101019822A discloses a three-cavity bag-packaged medium/long-chain fat emulsion, amino acid and glucose injection composition and a preparation method thereof, CN101019823A discloses a three-cavity bag-packaged structural fat emulsion, amino acid and glucose injection composition and a preparation method thereof, CN102772299A discloses a three-chamber transfusion bag for packaging soybean oil fat emulsion, amino acid and glucose injection, CN102772298A discloses a three-chamber transfusion bag for packaging medium/long-chain fat emulsion, amino acid and glucose injection, CN2686625 discloses a three-chamber bag for transfusion, CN202376452U discloses a three-chamber transfusion bag for packaging medium/long-chain fat emulsion, 16 amino acids and 16% glucose injection, and CN202376451U discloses a three-chamber transfusion bag for packaging soybean oil fat emulsion, 17 amino acids and 11% glucose injection.
Because the surface tension of the fat emulsion is greatly different from that of the amino acid injection and the glucose injection, the situations of emulsion damage, fat particle enlargement, phase separation and the like are easily caused when three injections are mixed due to the fact that each chamber is squeezed by force before clinical infusion, and clinical use is affected. Through a large number of tests and researches, the invention discovers that the ratio of each component in the three injections is in a specific range, no additive, especially pH regulator, is added, the problems can not occur after the three injections are mixed to obtain the clinical injection, and the stability is very good.
On the other hand, since long-chain fat emulsion derived from soybean oil can provide an excessive amount of polyunsaturated fatty acids (PUFA), the fatty acid composition is abnormal, lipid peroxidation is increased, and the production of eicosanoid derivatives is unbalanced. The three-cavity bag-packaged olive oil fat emulsion (the other long-chain fat emulsion based on olive oil), compound amino acid and glucose injection pharmaceutical composition provided by the invention can overcome the defect.
Disclosure of Invention
The invention aims to provide a three-cavity bag-packaged olive oil fat emulsion, a compound amino acid and glucose injection pharmaceutical composition and a preparation method thereof.
The technical scheme of the invention is as follows:
the invention provides a three-cavity bag packaged olive oil fat emulsion, compound amino acid and glucose injection pharmaceutical composition, wherein three cavities of a three-cavity bag are respectively filled with a fat emulsion injection, a compound amino acid injection and a glucose injection by adopting three cavities separated at intervals; wherein the olive oil fat emulsion comprises olive oil for injection, soybean oil for injection, lecithin for injection, glycerol for injection, sodium oleate and water for injection; the compound amino acid injection comprises L-alanine, L-arginine, L-aspartic acid, L-glutamic acid, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine (or L-lysine acetate), L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine and water for injection.
The olive oil fat emulsion injection contains the following components in each 1000 mL:
the rest is water for injection;
the compound amino acid injection contains the following components in each 1000 mL:
the rest is injection water; wherein L-lysine can also be replaced by L-lysine acetate, and the dosage of L-lysine acetate is 13.49-30.34g per 1000 mL;
the glucose injection contains 122.00-228.00g of anhydrous glucose or 134.00-251.00g of monohydrate glucose per 1000 mL.
Further, the compound amino acid injection may also contain per 1000 mL:
the invention relates to olive oil fat emulsion, compound amino acid and glucose injection packaged in three-cavity bags, wherein the volume of each cavity bag injection is respectively as follows: 255mL of olive oil fat emulsion injection, 300mL of compound amino acid injection and 885mL of glucose injection; it can also be: 250mL of olive oil fat emulsion injection, 500mL of compound amino acid injection and 500mL of glucose injection.
The invention also provides a preparation method of the olive oil fat emulsion, compound amino acid and glucose injection pharmaceutical composition packaged by the three-cavity bag, which comprises the following steps:
step one, bag making:
taking a plastic film for the inner bag, pressing the plastic film on a bag-making hot press to form, and connecting a filling opening;
taking the outer bag, pressing and forming the outer bag on a bag-making hot press, and leaving one side open;
step two, preparing liquid:
a. preparing an olive oil fat emulsion injection:
weighing the olive oil and the soybean oil for injection according to the prescription amount under the protection of nitrogen, stirring and mixing uniformly, filtering by a 0.22 mu m polypropylene filter element, heating to 60-80 ℃, adding the lecithin according to the prescription amount, and quickly stirring until the lecithin is uniformly dispersed to prepare an oil phase;
adding the injection water into the injection glycerol of the prescription amount, mixing uniformly, filtering by a 0.22 mu m polyethersulfone filter core, adding the sodium oleate of the prescription amount according to the prescription amount, stirring until the sodium oleate is completely dissolved, and preparing a glycerol aqueous solution (water phase) at the temperature of 60-70 ℃;
slowly adding the obtained oil phase into the prepared glycerin aqueous solution (water phase) under the protection of nitrogen and rapid stirring, uniformly mixing to form primary emulsion, and maintaining the temperature at 50-60 ℃;
homogenizing the prepared primary emulsion by a homogenizer, wherein the primary emulsion is firstly homogenized at a low pressure of 160bar for one time and then homogenized at a high pressure of 600bar for 4-6 times, and the temperature of each homogenization is controlled to be 45-55 ℃;
after the emulsion is qualified, filtering the emulsion by a polypropylene folding filter element with the diameter of 3 mu m to obtain the olive oil fat emulsion injection;
b. preparing a compound amino acid injection:
adding the components into pre-deoxygenated 60-90 deg.C water for injection one by one according to the prescription amount, stirring under nitrogen protection until dissolving, controlling the dissolved oxygen concentration in the liquid medicine not to be higher than 100ppm, and diluting to constant volume to obtain compound amino acid injection;
c. preparing a glucose injection:
dissolving anhydrous glucose or monohydrate glucose in water for injection according to a prescription, and diluting to a constant volume to obtain a glucose injection;
step three, filling, sealing and bagging outside:
respectively connecting the prepared fat emulsion injection, compound amino acid injection and glucose injection to a filling machine with three pipelines and filling units through a liquid medicine filter, vacuumizing the inner bag, filling with nitrogen gas, measuring the liquid medicine, controlling the filling amount and sealing;
filling the sealed inner bag into an outer bag, adding an oxygen absorbent between the inner bag and the outer bag, and removing oxygen between the inner bag and the outer bag and performing heat sealing by a heat sealing machine with the functions of vacuumizing the outer bag and filling nitrogen;
step four, sterilization:
spreading the packaged product on shelf of superheated water circulation spray type sterilizer, pressurizing the circulation water for sterilization, heating to high temperature, spraying onto the product, and maintaining at high temperature for 12-18 min.
The three-cavity bag-packaged olive oil fat emulsion, compound amino acid and glucose injection pharmaceutical composition provided by the invention does not need to be added with a pH regulator, and has the advantages of good stability, no damage to the emulsion during clinical infusion and mixing, stable oil particles, no phase separation and the like; the defect of unbalance of the fatty emulsion, the amino acid and the glucose injection fatty acid packaged by the existing three-cavity bag is overcome; the product of the invention has simple preparation process, controllable operation and easy realization of industrialization.
Detailed Description
The invention will now be further described by way of the following examples, which are not intended to limit the scope of the invention in any way. It will be understood by those skilled in the art that the equivalent substitutions and modifications made in the present disclosure are within the scope of the present invention.
EXAMPLE 1 preparation of three-chambered bag-packaged olive oil fat emulsion, Compound amino acid and glucose injection
The prescription of the olive oil fat emulsion injection:
the compound amino acid injection formula:
the prescription of the glucose injection comprises:
122.10g of anhydrous glucose (or 134.10g of monohydrate glucose),
water for injection was added to a total volume of 1L.
The preparation method comprises the following steps:
step one, bag making:
taking a plastic film for the inner bag, pressing the plastic film on a bag-making hot press to form, and connecting a filling opening;
taking the outer bag, pressing and forming the outer bag on a bag-making hot press, and leaving one side open;
step two, preparing liquid:
a. preparing an olive oil fat emulsion injection:
weighing the olive oil and the soybean oil for injection according to the prescription amount under the protection of nitrogen, stirring and mixing uniformly, filtering by a 0.22 mu m polypropylene filter element, heating to 60-80 ℃, adding the lecithin according to the prescription amount, and quickly stirring until the lecithin is uniformly dispersed to prepare an oil phase;
adding the injection water into the injection glycerol of the prescription amount, mixing uniformly, filtering by a 0.22 mu m polyethersulfone filter core, adding the sodium oleate of the prescription amount according to the prescription amount, stirring until the sodium oleate is completely dissolved, and preparing a glycerol aqueous solution (water phase) at the temperature of 60-70 ℃;
slowly adding the obtained oil phase into the prepared glycerin aqueous solution (water phase) under the protection of nitrogen and rapid stirring, uniformly mixing to form primary emulsion, and maintaining the temperature at 50-60 ℃;
homogenizing the prepared primary emulsion by a homogenizer, wherein the primary emulsion is firstly homogenized at a low pressure of 160bar for one time and then homogenized at a high pressure of 600bar for 4-6 times, and the temperature of each homogenization is controlled to be 45-55 ℃;
after the emulsion is qualified, filtering the emulsion by a polypropylene folding filter element with the diameter of 3 mu m to obtain the olive oil fat emulsion injection;
b. preparing a compound amino acid injection:
adding the components into pre-deoxygenated 60-90 deg.C water for injection one by one according to the prescription amount, stirring under nitrogen protection until dissolving, controlling the dissolved oxygen concentration in the liquid medicine not to be higher than 100ppm, and diluting to constant volume to obtain compound amino acid injection;
c. preparing a glucose injection:
dissolving anhydrous glucose or monohydrate glucose in water for injection according to a prescription, and diluting to a constant volume to obtain a glucose injection;
step three, filling, sealing and bagging outside:
respectively connecting the prepared fat emulsion injection, compound amino acid injection and glucose injection to a filling machine with three pipelines and filling units through a liquid medicine filter, vacuumizing the inner bag, filling with nitrogen gas, measuring the liquid medicine, controlling the filling amount and sealing;
filling the sealed inner bag into an outer bag, adding an oxygen absorbent between the inner bag and the outer bag, and removing oxygen between the inner bag and the outer bag and performing heat sealing by a heat sealing machine with the functions of vacuumizing the outer bag and filling nitrogen;
step four, sterilization:
spreading the packaged product on shelf of superheated water circulation spray type sterilizer, pressurizing the circulation water for sterilization, heating to high temperature, spraying onto the product, and maintaining at high temperature for 12-18 min.
EXAMPLE 2 preparation of three-chambered bag-packaged olive oil fat emulsion, Compound amino acid and glucose injection
The prescription of the olive oil fat emulsion injection:
the compound amino acid injection formula:
the prescription of the glucose injection comprises:
187.10g of anhydrous glucose (or 205.82g of monohydrate glucose),
water for injection was added to a total volume of 1L.
The preparation method is the same as example 1.
EXAMPLE 3 preparation of three-chambered bag-packaged olive oil fat emulsion, Compound amino acid and glucose injection
The prescription of the olive oil fat emulsion injection:
the compound amino acid injection formula:
the prescription of the glucose injection comprises:
227.78g of anhydrous glucose (or 250.56g of monohydrate glucose),
water for injection was added to a total volume of 1L.
The preparation method is the same as example 1.
EXAMPLE 4 preparation of three-chambered bag-packaged olive oil fat emulsion, Compound amino acid and glucose injection
The prescription of the olive oil fat emulsion injection:
the compound amino acid injection formula:
the prescription of the glucose injection comprises:
227.78g of anhydrous glucose (or 250.56g of monohydrate glucose),
water for injection was added to a total volume of 1L.
The preparation method is the same as example 1.
EXAMPLE 5 preparation of three-Chamber bag-packaged Olive oil fat emulsion, Compound amino acid and glucose injection
The prescription of the olive oil fat emulsion injection:
the compound amino acid injection formula:
the prescription of the glucose injection comprises:
178.97g of anhydrous glucose (or 196.87g of monohydrate glucose),
water for injection was added to a total volume of 1L.
The preparation method is the same as example 1.
EXAMPLE 6 preparation of three-chamber bagged olive oil fat emulsion, Compound amino acid and glucose injection
The prescription of the olive oil fat emulsion injection:
the compound amino acid injection formula:
the prescription of the glucose injection comprises:
178.97g of anhydrous glucose (or 196.87g of monohydrate glucose),
water for injection was added to a total volume of 1L.
The preparation method is the same as example 1.
Example 7 three-chambered bag mix Performance review and comparison
The results of the examination of the simulated clinical application of the three-cavity bag-packaged olive oil fat emulsion, compound amino acid and glucose injection samples prepared in examples 1, 3 and 5 of the invention and the three-cavity bag-packaged fat emulsion, amino acid and glucose injection samples prepared in example 1 of CN101015501A, CN101019822A and CN101019823A are shown in table 1 below.
TABLE 1 Performance examination and comparison of several three-chamber bag injections after mixing
Note: "+" indicates the presence of phase separation, "+" indicates the degree of phase separation, and "-" indicates no phase separation
As can be seen from Table 1, the CN101015501A, CN101019822A and CN101019823A samples show phase separation after being mixed and placed at room temperature and 4 ℃, the phase separation is more serious after 6 months at 40 ℃, the samples of the invention do not show phase separation after being placed at room temperature, 4 ℃ and 6 months at 40 ℃, and the particle size of the milk particles is obviously smaller than that of the CN101015501A, CN101019822A and CN101019823A samples, thus showing better stability.
According to the technical scheme, tests such as abnormal toxicity, allergy, hemolysis, local stimulation and the like of the prepared olive oil fat emulsion, compound amino acid and glucose injection pharmaceutical composition packaged by the three-cavity bag meet standard requirements through biological detection, and indexes such as content, pH, free fatty acid, bacterial endotoxin and the like are qualified through chemical detection.
Claims (1)
1. A three-cavity bag-packaged olive oil fat emulsion, compound amino acid and glucose injection pharmaceutical composition is characterized in that: the three-cavity bag adopts three cavities separated at intervals and is respectively filled with a fat emulsion injection, a compound amino acid injection and a glucose injection;
the olive oil fat emulsion injection contains the following components in each 1000 mL:
the rest is water for injection;
the compound amino acid injection contains the following components in each 1000 mL:
the rest is injection water; the L-lysine can also be replaced by L-lysine acetate, and the dosage of the L-lysine acetate is 13.50g per 1000 mL;
the glucose injection contains 122.10g of anhydrous glucose or 134.10g of monohydrate glucose per 1000 mL;
the preparation method of the olive oil fat emulsion, compound amino acid and glucose injection pharmaceutical composition packaged by the three-cavity bag comprises the following steps:
step one, bag making:
taking a plastic film for the inner bag, pressing the plastic film on a bag-making hot press to form, and connecting a filling opening;
taking the outer bag, pressing and forming the outer bag on a bag-making hot press, and leaving one side open;
step two, preparing liquid:
a. preparing an olive oil fat emulsion injection:
weighing the olive oil and the soybean oil for injection according to the prescription amount under the protection of nitrogen, stirring and mixing uniformly, filtering by a 0.22 mu m polypropylene filter element, heating to 60-80 ℃, adding the lecithin according to the prescription amount, and quickly stirring until the lecithin is uniformly dispersed to prepare an oil phase;
adding the injection water into the injection glycerol in the formula amount, mixing uniformly, filtering by using a 0.22 mu m polyether sulfone filter element, adding the sodium oleate in the formula amount according to the formula amount, stirring until the sodium oleate is completely dissolved, and preparing a glycerol aqueous solution, wherein the temperature is maintained at 60-70 ℃;
slowly adding the obtained oil phase into the prepared glycerin aqueous solution under the protection of nitrogen and rapid stirring, uniformly mixing to form primary emulsion, and maintaining the temperature at 50-60 ℃;
homogenizing the prepared primary emulsion by a homogenizer, wherein the primary emulsion is firstly homogenized at a low pressure of 160bar for one time and then homogenized at a high pressure of 600bar for 4-6 times, and the temperature of each homogenization is controlled to be 45-55 ℃;
after the emulsion is qualified, filtering the emulsion by a polypropylene folding filter element with the diameter of 3 mu m to obtain the olive oil fat emulsion injection;
b. preparing a compound amino acid injection:
adding the components into pre-deoxygenated 60-90 deg.C water for injection one by one according to the prescription amount, stirring under nitrogen protection until dissolving, controlling the dissolved oxygen concentration in the liquid medicine not to be higher than 100ppm, and diluting to constant volume to obtain compound amino acid injection;
c. preparing a glucose injection:
dissolving anhydrous glucose or monohydrate glucose in water for injection according to a prescription, and diluting to a constant volume to obtain a glucose injection;
step three, filling, sealing and bagging outside:
respectively connecting the prepared fat emulsion injection, compound amino acid injection and glucose injection to a filling machine with three pipelines and filling units through a liquid medicine filter, vacuumizing the inner bag, filling with nitrogen gas, measuring the liquid medicine, controlling the filling amount and sealing;
filling the sealed inner bag into an outer bag, adding an oxygen absorbent between the inner bag and the outer bag, and removing oxygen between the inner bag and the outer bag and performing heat sealing by a heat sealing machine with the functions of vacuumizing the outer bag and filling nitrogen;
step four, sterilization:
spreading the packaged product on shelf of superheated water circulation spray type sterilizer, pressurizing the circulation water for sterilization, heating to high temperature, spraying onto the product, and maintaining at high temperature for 12-18 min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510000508.6A CN105816502B (en) | 2015-01-04 | 2015-01-04 | Three-cavity bag-packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510000508.6A CN105816502B (en) | 2015-01-04 | 2015-01-04 | Three-cavity bag-packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105816502A CN105816502A (en) | 2016-08-03 |
| CN105816502B true CN105816502B (en) | 2019-12-27 |
Family
ID=56986721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510000508.6A Active CN105816502B (en) | 2015-01-04 | 2015-01-04 | Three-cavity bag-packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105816502B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102443962B1 (en) * | 2020-07-21 | 2022-09-20 | (주)엠지 | 3-chamber bag infusion preparation |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015501A (en) * | 2007-02-28 | 2007-08-15 | 华瑞制药有限公司 | Injection composition of fat milk, amino acid and glucose packed with three-cavity bag and preparing method thereof |
| CN101019823A (en) * | 2007-03-23 | 2007-08-22 | 华瑞制药有限公司 | Separately packed structural fatty milk, aminoacid and glucose injection composition and the prepn process |
| CN101019822A (en) * | 2007-03-23 | 2007-08-22 | 华瑞制药有限公司 | Separately packed fatty milk, amino acid and glucose injection composition and the prepn process |
| CN103720741A (en) * | 2014-01-07 | 2014-04-16 | 辽宁海思科制药有限公司 | Medium-and-long-chain fat emulsion/amino acid (16)/glucose (16 percent) composition for injection |
| CN103735607A (en) * | 2014-01-07 | 2014-04-23 | 辽宁海思科制药有限公司 | Novel injection composition for packaging fat emulsion and amino acid (17) glucose (11 percent) |
-
2015
- 2015-01-04 CN CN201510000508.6A patent/CN105816502B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015501A (en) * | 2007-02-28 | 2007-08-15 | 华瑞制药有限公司 | Injection composition of fat milk, amino acid and glucose packed with three-cavity bag and preparing method thereof |
| CN101019823A (en) * | 2007-03-23 | 2007-08-22 | 华瑞制药有限公司 | Separately packed structural fatty milk, aminoacid and glucose injection composition and the prepn process |
| CN101019822A (en) * | 2007-03-23 | 2007-08-22 | 华瑞制药有限公司 | Separately packed fatty milk, amino acid and glucose injection composition and the prepn process |
| CN103720741A (en) * | 2014-01-07 | 2014-04-16 | 辽宁海思科制药有限公司 | Medium-and-long-chain fat emulsion/amino acid (16)/glucose (16 percent) composition for injection |
| CN103735607A (en) * | 2014-01-07 | 2014-04-23 | 辽宁海思科制药有限公司 | Novel injection composition for packaging fat emulsion and amino acid (17) glucose (11 percent) |
Non-Patent Citations (1)
| Title |
|---|
| 长链脂肪乳注射液;戴德银等;《实用新药特药手册》;人民军医出版社;20120531;第1076页"长链脂肪乳注射液" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105816502A (en) | 2016-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102661782B1 (en) | Reconstitution devices, systems, and methods for administering drugs in appropriate boluses | |
| CN101015501B (en) | Injection composition of fat milk, amino acid and glucose packed with three-cavity bag and preparing method thereof | |
| CN104013571B (en) | A kind of ornidazole injection and preparation method thereof | |
| JP2008513105A (en) | Bypass line connector for mixing systems | |
| CN100467012C (en) | Separately packed structural fatty milk, aminoacid and glucose injection composition and the prepn process | |
| CN102631665B (en) | Pharmaceutical composition of alanyl glutamine injection and compound amino acid injection | |
| CN101019822A (en) | Separately packed fatty milk, amino acid and glucose injection composition and the prepn process | |
| CN105816502B (en) | Three-cavity bag-packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof | |
| CN106794163A (en) | Aqueous formulation comprising paracetamol and brufen | |
| CN103040740A (en) | Ornidazole injection and preparation technology thereof | |
| CN113301882A (en) | Reconstitution system for administering drugs via high vacuum vial using integrated airway tube | |
| KR20210021029A (en) | Reconstitution system for administering drugs through high vacuum bottles | |
| CN106265857B (en) | Preparation method of fat emulsion, amino acid and glucose injection packaged in three-cavity bag | |
| CN111603442A (en) | Fat emulsion, compound amino acid and glucose injection and preparation method thereof | |
| CN103720741A (en) | Medium-and-long-chain fat emulsion/amino acid (16)/glucose (16 percent) composition for injection | |
| CN102228428A (en) | Large volume injection composition containing vinpocetine and preparation method thereof | |
| CN104622895B (en) | A kind of preparation method for the Mannitol sodium chloride injection packed with Double-cavity bag | |
| CN202376452U (en) | Novel three-chamber transfusion bag used for packaging medium-long-chain fat emulsion, 16 amino acids and 16% dextrose injection | |
| CN108329440B (en) | Low drug adsorption TPS and preparation method and application thereof | |
| CN106902144A (en) | The preparation method and said composition of a kind of middle long chain fat emulsion, amino acid and glucose injection composition | |
| CN208877295U (en) | A kind of three chamber infusion bags for long chain fat emulsion, amino acid and compound glucose electrolyte injection in packing | |
| CN208541574U (en) | A kind of packaging olive oil Fat Emulsion, amino acid and compound glucose injection multi-cavity chamber infusion bag | |
| CN106265856B (en) | Preparation method of fat emulsion, amino acid and glucose injection packaged in three-cavity bag | |
| CN102697716A (en) | Double-cavity bagged vitamin C injection and preparation method thereof | |
| CN208574074U (en) | A kind of multi-chambered transfusion bag for packing Fat Emulsion, amino acid and compound glucose injection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |