CN105796645A - Concealed nasal patch capable of reliving rhinobyon and preparation method of concealed nasal patch - Google Patents
Concealed nasal patch capable of reliving rhinobyon and preparation method of concealed nasal patch Download PDFInfo
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- CN105796645A CN105796645A CN201610353652.2A CN201610353652A CN105796645A CN 105796645 A CN105796645 A CN 105796645A CN 201610353652 A CN201610353652 A CN 201610353652A CN 105796645 A CN105796645 A CN 105796645A
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- quintessence oil
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- flos magnoliae
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000000341 volatile oil Substances 0.000 claims abstract description 15
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- 239000008273 gelatin Substances 0.000 claims abstract description 13
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- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 13
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- 238000001467 acupuncture Methods 0.000 claims abstract description 8
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- 238000005516 engineering process Methods 0.000 claims abstract description 4
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- IAXUQWSLRKIRFR-SAABIXHNSA-N chembl2104696 Chemical compound C1C[C@@H](CNC(=N)N)CC[C@@H]1C(=O)OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 IAXUQWSLRKIRFR-SAABIXHNSA-N 0.000 claims description 12
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 6
- 229920002674 hyaluronan Polymers 0.000 claims description 6
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
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- 239000001116 FEMA 4028 Substances 0.000 abstract description 5
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract description 5
- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract description 5
- 229960004853 betadex Drugs 0.000 abstract description 5
- 150000001875 compounds Chemical class 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000012620 biological material Substances 0.000 abstract description 2
- 241000218394 Magnolia liliiflora Species 0.000 abstract 1
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000001102 lavandula vera Substances 0.000 abstract 1
- 235000018219 lavender Nutrition 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
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- 229940010747 sodium hyaluronate Drugs 0.000 abstract 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 abstract 1
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- 229940079593 drug Drugs 0.000 description 6
- 206010002198 Anaphylactic reaction Diseases 0.000 description 4
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- 206010015544 Eustachian tube obstruction Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a concealed nasal patch capable of reliving rhinobyon and a preparation method of the concealed nasal patch. The nasal patch is composed of an elastic biocolloid body and a transparent back patch body, wherein the elastic biocolloid body is prepared from a biological framework material and a medicinal beta-cyclodextrin inclusion compound; the biological framework material is prepared from a matrix material (namely, gelatin or polyving akohol), an adhesive (namely, sodium hyaluronate or polyethylene glycol), and a humectant (namely, glycerol or propylene glycol); the medicinal beta-cyclodextrin inclusion compound is prepared from volatile oil of magnolia liliflora, peppermint essential oil and lavender essential oil through a beta-cyclodextrin inclusion technology. The elastic biocolloid body is in the shape of a hemisphere or a semiellipse tallying with the Yingxiang acupuncture point, and has the diameter being 2-5 mm. The nasal patch takes a macromolecular biological material as a carrier, has the advantages that the efficacy is stable, the medicine release time is prolonged, the structure is small and exquisite as well as concealed, the use is convenient and comfortable, the targeted drug delivery can be realized at the acupuncture point, the efficacy is significant, the effects are rapid, etc.
Description
Technical field
The present invention relates to a kind of stealthy nose patch alleviating nasal obstruction and preparation method thereof.
Background technology
According to epidemiologic data, In Guangdong Province examinee's allergic rhinitis prevalence of growing up is 15.6%.Particularly, by haze
Weather affects, and PM2.5 is inhaled into human body, makes patients with rhinitis in rising trend.
Rhinitis is nasal mucosa or sub-mucosal tissues because virus or antibacterial infect and foreign body stimulation etc., causes caused by tissue damaged
Acute and chronic inflammation.Rhinitis can produce too much mucus, generally causes the symptom such as watery nasal discharge, nasal obstruction.And have a stuffy nose because of nose breathing not
Freely, make patient do not feel like oneself, thus have impact on sleep, working and learning;Nasal obstruction may result in eustachian tube obstruction, even audition
Going down, child is especially prevalent;Nasal obstruction also can cause snoring, insomnia and hypertension, and health is formed threat greatly.
At present, more effective Therapeutic Method is to find out anaphylactogen, fights off this anaphylactogen of contact, to reduce morbidity.West
Doctor there is no specific medicament and method to this disease.Treatment nasal obstruction would generally use oral drugs, but oral drugs can not be in short-term
The interior problem solving nasal obstruction.Because oral drugs need to cause the peak of medicine through absorbing and filtering processes such as stomach, liver and kidneys
Paddy phenomenon, brings the medicine source hurt to whole body, causes the side effect such as medication person's immunity degradation, and onset is slow.
Also have the ventilating nasal for alleviating nasal obstruction to paste on market, but there is skin allergy, comfortableness is poor, effective drug duration is short, make
By inconvenient, the problem such as unsightly.
Summary of the invention
For overcoming disadvantages described above, the invention provides a kind of stealthy nose patch alleviating nasal obstruction and preparation method thereof.This nose pastes, choosing
Being carrier with polymeric biomaterial, have efficacy stability, extend drug release time, compact structure is stealthy, easy to use comfortable,
Can be at acupuncture point target administration, the advantages such as drug effect is notable, and onset is rapid.
This nose patch includes elastic biological colloid and transparent back of the body patch material.
Elastic biological colloid is made up of with medicine Benexate Hydrochloride biological skeleton material.
Biological skeleton material is then made up of host material, adhesive and wetting agent;The preferred gelatin of host material or polyvinyl alcohol (in
Viscosity) in one or both;Adhesive preferably clear matter is sour or one or both in medical Polyethylene Glycol;Wetting agent is excellent
Select in glycerol or propylene glycol one or both.Wherein, host material, adhesive and wetting agent by mass fraction ratio are
2-4:1-2:1-2。
Medicine Benexate Hydrochloride divides daily type and night using type, daily type to be Flos Magnoliae quintessence oil and Peppermint essential oil compositions;Night
It is Flos Magnoliae quintessence oil and Herba Lysimachiae foenum-graeci quintessence oil compositions by type.Above-mentioned composition and beta-schardinger dextrin-by inclusion technique make medicine β-
Cyclodextrin clathrate, optimum ratio by volume/mass ratio is calculated as 1:2-20.
In Flos Magnoliae quintessence oil and Peppermint essential oil compositions, optimum ratio is 1-10:1-5 by volume.
In Flos Magnoliae quintessence oil and Herba Lysimachiae foenum-graeci quintessence oil compositions, optimum ratio is 1-10:1-5 by volume.
This nose pastes by Yingxiang acupuncture point transdermal administration, and elastic biological colloid is to agree with that the semicircle at Yingxiang acupuncture point is spherical or half elliptic,
Diameter 2-5mm.
The preparation method of described stealthy nose patch, comprises the following steps:
(1), the preparation of medicine Benexate Hydrochloride, use saturated water solution method or ultrasonic method that beta-schardinger dextrin-is dissolved in steaming
Distilled water makes saturated solution, adds Flos Magnoliae quintessence oil and the compositions of Peppermint essential oil or Flos Magnoliae quintessence oil and the compositions of Herba Lysimachiae foenum-graeci quintessence oil,
Make medicine Benexate Hydrochloride;
(2) preparation of elastic biological colloid, by the most complete for the host material gelatin and polyvinyl alcohol preparing biological skeleton material
It is dissolved in water;Under the conditions of water-bath 70-80 DEG C, after aqueous gelatin solution is completely dissolved in polyvinyl alcohol water solution, reduce the temperature to
50-60℃;Add adhesive hyaluronic acid or medical Polyethylene Glycol, wetting agent glycerol or propylene glycol and medicine beta-schardinger dextrin-
Clathrate, stirs and makes elastic biological colloid;
(3) elastic biological colloid is poured into film applicator press-in plastic packaging template, makes target product.
Mold Making can be made into that the small semicircle agreeing with acupuncture point of diameter 2-5mm is spherical or half elliptic.The life of back of the body patch material transparent
Fibres element film, diameter 5-10mm, it is coated with hydrophilic viscous coating, color is consistent with skin, plays the effect of stealth.
Compared with prior art, the method have the advantages that
1, the present invention is with tcm theory as foundation, the nose patch natural plant volatile oil containing special compatibility, point daily type and night
By type, add Peppermint essential oil formula with Flos Magnoliae quintessence oil daytime, alleviate outside nasal obstruction, itching-relieving action, moreover it is possible to refreshment;Night is used
Flos Magnoliae quintessence oil, with addition of Herba Lysimachiae foenum-graeci quintessence oil formula, is dredged clearing the nasal passage, is effectively improved sleep;
2, the present invention is combined by beta-cyclodextrin inclusion compound technology and biological skeleton material, makes the laminating cave of diameter 5-10mm
The special construction of position so that it is slowly discharge at fragrant cave, Transdermal absorption, plays massage, expansion nasal passage, clearing the nasal passage
Function;
3, the present invention passes through the use of stealth material and special moulding process, and structure is small, and material color is consistent with skin,
Play the effect of stealth, due to patch small volume, even can also be attached to nasal cavity, easy to use comfortable.
4, being proved by specific safety test, the nose of the present invention pastes not allergy non-stimulated to skin, efficacy stability, is up to
8-12 hour.
Accompanying drawing explanation
Accompanying drawing is the nose patch structural representation of the present invention.
Detailed description of the invention
Technical scheme is further illustrated below by way of specific embodiment.
Embodiment 1
Use saturated water solution method, take Flos Magnoliae quintessence oil and compositions 1mL that Peppermint essential oil (volume ratio 4: 1) forms, add nothing
Water-ethanol 1ml mixes.Separately taking beta-schardinger dextrin-8g, be dissolved in 100mL distilled water, heating in water bath dissolves, and is cooled to 40 DEG C,
It is placed in constant temperature blender with magnetic force, adds volatile oil ethanol, be slowly dropped in beta-schardinger dextrin-solution with syringe, add
Plug, stirs 1h, the cold 24h that puts, sucking filtration, and petroleum ether rinses 3 times, is deposited in 40 DEG C of vacuum drying 6h, obtains β-ring and stick with paste
Inclusion compounds.
Take gelatin 10g add water 10-30ml soak 6-12 hour, polyvinyl alcohol 5g add water 10-20ml soak 6-12 hour,
Stirring poly-vinyl alcohol solution under the conditions of water-bath 80 DEG C, be slowly added into gelatin solution in time being completely dissolved, stirring and dissolving is complete
After reduce the temperature to 50 degree, add hyaluronic acid 5g, glycerol 5g, Benexate Hydrochloride 5g, after stirring fall
Enter film applicator press-in plastic packaging template, packed products.
Embodiment 2
Use ultrasonic method, weigh about beta-schardinger dextrin-4g, be dissolved in distilled water (45 DEG C) preparation saturated solution.Add Flos Magnoliae essence
The compositions 1ml mixing of oil and Herba Lysimachiae foenum-graeci quintessence oil (volume ratio 9: 1), 45 DEG C of thermostatic ultrasonics process 30min, put in refrigerator
Cold preservation 24h, takes out sucking filtration, with a little absolute ethanol washing 3 times.Powder is put vacuum desiccator is dried 24h, to obtain final product
Benexate Hydrochloride.
Take gelatin 5g add water 10-20ml soak 4-8 hour, polyvinyl alcohol 5g add water 10-20ml soak 4-8 hour,
Stir poly-vinyl alcohol solution under the conditions of water-bath 70 DEG C, in time being completely dissolved, be slowly added into gelatin solution, after stirring and dissolving is complete
Reduce the temperature to 50 degree, add hyaluronic acid 10g, glycerol 10g, Benexate Hydrochloride 5g, fall after stirring
Enter film applicator press-in plastic packaging template, packed products.
Embodiment 3
Using saturated water solution method, compositions 2ml taking Flos Magnoliae quintessence oil and Peppermint essential oil (volume ratio 9: 1) adds anhydrous second
Alcohol 2ml mixes, and separately takes beta-schardinger dextrin-10g, dissolves, be cooled to 40 DEG C, put after being dissolved in distilled water 100mL heating in water bath
In constant temperature blender with magnetic force, add compositions ethanol, be slowly dropped in cyclodextrin solution with syringe, jump a queue, stir
Mixing 2h, the cold 24h that puts, sucking filtration, petroleum ether rinses 3 times, is deposited in 40 DEG C of vacuum drying 6h, obtains beta-schardinger dextrin-bag
Compound.
Take gelatin 10g add water 10-30ml soak 6-12 hour, polyvinyl alcohol 5g add water 10-20ml soak 6-12 hour,
Whisking gelatin solution under the conditions of water-bath 80 DEG C, is slowly added into poly-vinyl alcohol solution in time being completely dissolved, and stirring and dissolving is complete
After reduce the temperature to 60 DEG C, add hyaluronic acid 5g, glycerol 5g, Benexate Hydrochloride 10g, after stirring fall
Enter film applicator press-in plastic packaging template, packed products.
Embodiment 4
Manufacture method: mould makes that the small semicircle agreeing with Yingxiang acupuncture point shape of diameter 2-5mm is spherical or half elliptic, will system
It is central that the colloid plane become sticks in back of the body patch.
As shown in drawings, 1 is elastic biological colloid to the structure of nose of the present invention patch, and semicircle is spherical or half elliptic, diameter 2-5mm;
2 is back of the body patch material, for transparent biological cellulose membrane, diameter 5-10mm, is coated with hydrophilic viscous coating.
Embodiment 5
Local irritation and anaphylaxis evaluation: with reference to " Chinese medicine, natural drug zest and hemolytic investigative technique guideline "
2005.3, irritation test, result shows: intact skin and the damaged skin of white rabbit are not produced by this clearing the nasal passage nose patch
Raw zest, prompting nose patch external does not produce irritative response.
With reference to " technological guidance's principle that Chinese medicine, natural drug immunotoxicity (anaphylaxis, photo sensitive reaction) are studied " 2005.3,
Actively skin anaphylactic test, result shows: this clearing the nasal passage nose patch does not produce anaphylaxis to guinea pig skin, and prompting nose patch external is not
Produce anaphylaxis.
Claims (6)
1. the stealthy nose patch alleviating nasal obstruction, pastes including elastic biological colloid and the transparent back of the body, it is characterised in that: described
Elastic biological colloid is made up with medicine Benexate Hydrochloride of biological skeleton material, described medicine Benexate Hydrochloride
Compositions and beta-schardinger dextrin-by Flos Magnoliae quintessence oil and the compositions of Peppermint essential oil or Flos Magnoliae quintessence oil and Herba Lysimachiae foenum-graeci quintessence oil pass through inclusion
Technology is made.
2. as claimed in claim 1 stealthy nose patch, it is characterised in that: described biological skeleton material by host material,
Adhesive and wetting agent are made;Described host material includes one or both in gelatin or polyvinyl alcohol;Described bonding
Agent includes one or both in hyaluronic acid or medical Polyethylene Glycol;Described wetting agent includes in glycerol or propylene glycol
One or both.
3. the most stealthy nose patch, it is characterised in that: described host material, adhesive and moisturizing
Agent by mass fraction ratio is: 2-4:1-2:1-2.
4. the most stealthy nose patch, it is characterised in that: described elastic biological colloid is diameter 2-5mm,
Agree with that the semicircle at Yingxiang acupuncture point is spherical or half elliptic.
5. the stealthy nose patch as described in claims 1 to 4, it is characterised in that: described Flos Magnoliae quintessence oil and Peppermint essential oil
Compositions in the proportioning of Flos Magnoliae quintessence oil and Peppermint essential oil be 1-10:1-5 by volume;Described Flos Magnoliae quintessence oil and lavandula angustifolia
In the compositions of quintessence oil, the proportioning of Flos Magnoliae quintessence oil and Herba Lysimachiae foenum-graeci quintessence oil is 1-10:1-5 by volume;Described compositions and β-
The proportioning of cyclodextrin by volume/mass ratio is 1:2-20.
6. the preparation method of stealthy nose patch as described in claim 1 to 4, it is characterised in that comprise the following steps:
(1) preparation of medicine Benexate Hydrochloride, uses saturated water solution method or ultrasonic method that beta-schardinger dextrin-is dissolved in distillation
Water makes saturated solution, adds Flos Magnoliae quintessence oil and the compositions of Peppermint essential oil or Flos Magnoliae quintessence oil and the compositions of Herba Lysimachiae foenum-graeci quintessence oil,
Make medicine Benexate Hydrochloride;
(2) preparation of elastic biological colloid, by the most complete for the host material gelatin or polyvinyl alcohol preparing biological skeleton material
It is dissolved in water;Under the conditions of water-bath 70-80 DEG C, after aqueous gelatin solution is completely dissolved in polyvinyl alcohol water solution, reduce the temperature to
50-60℃;Add adhesive hyaluronic acid or medical Polyethylene Glycol, wetting agent glycerol or propylene glycol and medicine beta-schardinger dextrin-
Clathrate, stirs and makes elastic biological colloid;
(3) elastic biological colloid is poured into film applicator press-in plastic packaging template, makes target product.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106727443A (en) * | 2016-12-08 | 2017-05-31 | 武汉大学 | Preoperative calm stealthy nose paste preparation of a kind of pediatric anesthesia and preparation method thereof |
CN108211108A (en) * | 2018-03-01 | 2018-06-29 | 中南民族大学 | A kind of microvesicle patch and preparation method being administered continuously for acupuncture point |
CN112843197A (en) * | 2021-03-16 | 2021-05-28 | 长春中医药大学附属医院(吉林省中医院) | Epidemic prevention nose patch formula extracted from traditional Chinese medicine and preparation process |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN101884668A (en) * | 2010-07-06 | 2010-11-17 | 山东赛克赛斯药业科技有限公司 | Composition for preventing and treating allergic rhinitis and preparation method thereof |
CN102319292A (en) * | 2011-08-04 | 2012-01-18 | 张玲环 | The essential oil component and the application thereof of treatment rhinitis |
CN104997847A (en) * | 2015-08-19 | 2015-10-28 | 成都善嘉生物医药有限责任公司 | Medical cold compress nose paste for relieving nasal plug and realizing nose ventilation |
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2016
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101884668A (en) * | 2010-07-06 | 2010-11-17 | 山东赛克赛斯药业科技有限公司 | Composition for preventing and treating allergic rhinitis and preparation method thereof |
CN102319292A (en) * | 2011-08-04 | 2012-01-18 | 张玲环 | The essential oil component and the application thereof of treatment rhinitis |
CN104997847A (en) * | 2015-08-19 | 2015-10-28 | 成都善嘉生物医药有限责任公司 | Medical cold compress nose paste for relieving nasal plug and realizing nose ventilation |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106727443A (en) * | 2016-12-08 | 2017-05-31 | 武汉大学 | Preoperative calm stealthy nose paste preparation of a kind of pediatric anesthesia and preparation method thereof |
CN108211108A (en) * | 2018-03-01 | 2018-06-29 | 中南民族大学 | A kind of microvesicle patch and preparation method being administered continuously for acupuncture point |
CN108211108B (en) * | 2018-03-01 | 2024-03-15 | 中南民族大学 | Microbubble patch for acupoint sustained drug administration and preparation method thereof |
CN112843197A (en) * | 2021-03-16 | 2021-05-28 | 长春中医药大学附属医院(吉林省中医院) | Epidemic prevention nose patch formula extracted from traditional Chinese medicine and preparation process |
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Application publication date: 20160727 |