CN105770726A - Traditional Chinese medicine composition for preventing and treating colorectal polyps - Google Patents
Traditional Chinese medicine composition for preventing and treating colorectal polyps Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating colorectal polyps.The traditional Chinese medicine composition is prepared from roots of hairy asiabell, rhizoma atractylodis macrocephalae, milkvetch roots, semen coicis, round cardamon seeds, spreading hedyotis herb, rhizoma curcumae, panax notoginseng tablets and honey-fried licorice roots.The traditional Chinese medicine composition can effectively relieve posttreatment symptoms of patients subjected to endoscopic adenomatous colorectal polyp removing operations.It is shown through clinical data that the overall average symptom score before treatment is 3.00+/-0.96, the overall average symptom score after treatment is 0.87+/-0.62, the difference has statistical significance (the value is 13.07, P is smaller than 0.05), the numbers of patients with tubular adenoma, villous adenoma and mixed adenoma are all decreased, the clinical symptoms of the patients with the colorectal polyps can be effectively relieved, and the recurrence rate of patients subjected to endoscopic colorectal polyp removing is effectively decreased.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly to a kind of Chinese medicine composition preventing and treating colorectal polyp.
Background technology
Colorectal polyp (colorectal polyps) refers to, above mucous membrane, the neoplasm to enteric cavity of dashing forward, can have the base of a fruit,
Can also be wide base without the base of a fruit, be apt to occur in rectum and sigmoid colon, the incidence of disease is about 40%, and wherein 70%～80% is adenomatous.
Colorectal polyp is closely related with the generation of colorectal cancer, and the colorectal cancer of 50%～80% is to occur on the basis of adenoma, i.e. so-called
" adenoma one cancer " sequence.Therefore, adenomatous colorectal polyp is referred to as the precancerous lesion of colorectal cancer.Adenomatous colorectal polyp recurs
And canceration is the most relevant with its histological type, dysplasia degree, size, form and quantity.In adenomatous colorectal polyp with
Villous adenoma canceration rate is the highest, is 25%～40%, and tubular adenoma is minimum, is 3.0%～8.5%, adenoma mixed
Asking between both；The dysplasia degree of adenoma is the highest, and the danger of canceration is the biggest.Extract colorectal polyp under scope and reduce it
Recurrence rate and recurrence rate, its Postoperative recurrent rate is about 30%.Morson etc. to 1000 example Colon and rectum adenomas extract patients carry out with
Visiting, in 2 years, accumulative recurrence rate is 75.5% [11].
The colorectal polyp of clinical diagnosis include on pathology adenomatous polyp, hamartomatous polyp (juvenile polyp,
Peutz Jeghers polyp etc.), inflammatory polyp and other (metaplastic polyp and mucosal mast neoplasm).Total score is tumprigenicity
And Non-cancerous, the former is in close relations with carcinogenesis, is precancerous lesion, and the latter is less with carcinogenesis relation.Due to both
Polyp is not easy to distinguish clinically, can only clarify a diagnosis according to pathological examination, therefore often system is using colorectal polyp as diagnosis.
Due to diet and environment, the incidence of disease of colorectal polyp rises year by year.Guangdong Provincial TCM Hospital endoscope center 15
The recall rate about 5-10% of colorectal polyp in all enteroscopy crowds before year, and rise to 30-40% at present.Colorectal polyp
The incidence of disease and age have substantial connection.The incidence of disease of less than 40 years old crowds is 20%-30%, and the morbidity of more than 40 years old crowd
Rate then rises to 40%～50%.Colorectal polyp harm is relatively big, great mass of data prove the colorectal cancer of 93% derive from adenomatous greatly
Intestinal polyp, the colorectal cancer incidence rate of Colorectal Adenomas patient is higher than 4 times of normal population, and adenomatous colorectal polyp is referred to as colorectal cancer
Precancerous lesion, developing into cancer from adenoma averagely needs 3～17 years [1-2].
The main method of western medical treatment colorectal polyp gives Endoscopic removal after being diagnosis clearly at present, but for this disease
Early prevention and some common clinical symptoms after being ill, the improvement such as symptoms such as diarrhoea, stomachache, bowel habit changes is failed to understand
Aobvious or without effect and invalid to polyp postoperative recurrence.Report both at home and abroad, colorectal polyp recurrence rate 30% after excision～
50%, adenoma multiple is higher than solitary recurrence rate, and in 2 years, accumulative recurrence rate is 75.5% [3].Therefore, preventing and treating colorectal polyp art
Rear recurrence, is to reduce incidence of colorectal and improve the key of colorectal polyp life in patients.And use traditional Chinese medicine prevention big
Intestinal polyp postoperative recurrence has preferable curative effect, and shows good prospect.
Large intestine " polyp " one word, ancient books sees "Nei Jing" the earliest." Ling Shu Miraculous Pivot or Divine Axis water swelling " day: " ovarian cyst how?Qi uncle day: cold
Gas visitor, in parenteral, fights with defending gas phase, and gas must not be flourish, because there being direct bearing, addiction and interior, bad odor has been, polyp is raw." due to history
Condition limits, and forefathers cannot see concrete Colon and rectum site of pathological change, and traditional Chinese medicine is recorded without the disease of colorectal polyp.Face according to it
Bed performance, can belong to the disease categories such as the traditional Chinese medical science " ovarian cyst ", " internal medicine knurl is sick ", " enteroncus ".About its etiology and pathogenesis, mostly recognize
It is the pathogenic characteristic of this disease for asthenia in origin and asthenia in superficiality, simulataneous insufficiency and excessive.This void is " deficiency-weakness of spleen-QI ", and mark is real is damp and hot, cold-dampness, wet turbid, phlegm
The stasis of blood that is turbid and that cause therefrom is turbid, stop [4] in hemostasis.This disease clinical with stomachache, diarrhoea, constipation, have blood in stool, mucus is just for main disease
Shape, or without significant discomfort symptom, only find during enteroscopy.
Colorectal polyp is included in clinical main attack disease and is planted by Guangdong Provincial TCM Hospital GI Medicine, has included clinical path in more than 8 years.Liu
Add literary composition etc. and use cross section, Retrospective review research method, by colorectal polyp patients symptomatic's analysis and summary, thus draw it
Characteristics of TCM types.Result: colorectal polyp patient card type merely only accounts for 16.5%；Compound card type accounts for 83.5%, two of which
Card type is compound accounts for 57.8%, and 3 kinds of card types are combined and account for 25.6%, and the patient stopping card in being directed to blood stasis has 8O example, coverage rate
73.4%；Syndrome of dampness-heat in large intestine then takes second place with 71 examples, coverage rate 65.1%；Weakness of the spleen and stomach has 66 examples, coverage rate 60.5%
.Conclusion: this research prompting is weakness of the spleen and the stomach, large intestinal damp-heat is to produce the important pathologic basis of colorectal polyp, and in the with the passing of time hyperamization stasis of blood
Stop, three's common pathogenetic, produce colorectal polyp, mutually double based on two cards or three cards in clinical card type.Therefore in clinical path, greatly
The Syndrome Differentiation of Traditional Chinese Medicine of intestinal polyp is: insufficiency of the spleen wet stasis syndrome, syndrome of stagnant dampness-heat, syndrome of qi stagnation and blood stasis, and 80% colorectal polyp clinically
TCM Syndrome Type is: insufficiency of the spleen wet stasis syndrome [5].
Treating this disease answers sample actual situation to take into account, and invigorating the spleen to clear away damp pathogen, dissipating phlegm and removing blood stasis are for treating big method.Modern Chinese medicine research aspect,
Xu Fulin uses tonifying Qi stagnation resolvation, gut purge to disappear the method for knot, is main to treat colorectal polyp 30 example, result with card plus-minus with invigorating the spleen Yikang soup
Clinical cure l4 example, effective 6 examples, take a turn for the better 8 examples, invalid 2 examples [6].Ma Baihan is from intending invigorating blood circulation message soup (red sage root 30g, Radix Sangusorbae
15g, Chinese trumpet creeper 15g, Sculellaria barbata 15g, pink 12g, radix paeoniae rubrathe 12g, stir-baked SQUAMA MANITIS 12g, spina gleditsiae 12g, Rhizoma Sparganii 12g, root bark of tree peony 12g,
Sophora bud 12g, edible tulip l2g, root of bidentate achyranthes l2g), treat pipe intestinal polyp 3O example, result cures 25 examples, effective 3 examples, invalid 2 examples, puts down
All take medicine 24～65 doses [7].Huang Limei etc. calm down soup retention-enema treatment intestinal polyp with Chinese medicine and extract postoperative patient 62 example, half a year
Check intestines mirror 1 time, follows the trail of 2 years altogether, and recurrence rate is respectively 9.67% and 29.0% [8]；The foundation theory of traditional Chinese medical science such as Yan little Jun is to knot
The etiology and pathogenesis of intestines precancerous lesion, diagnose dialectical, therapeutic rule and have made extensive and intensive studies, and achieve comparatively ideal
Clinical efficacy, he thinks that accumulateing in Tianjin weakness of the spleen and the stomach, cloudy consumption wound, intestines network stasis blocking, malicious heresy is that the pathology machine of Precancerous Lesion of Colon turns.Strong
Spleen nourishing yin and activating blood heat-clearing side medicine can improve sick cell level of apoptosis, promotes sick cell apoptosis, thus blocks colon precancerosis
The development become, reverses colonic mucosa intraepithelial neoplasia (cin) [9].
Traditional Chinese medicine improve the clinical symptoms of colorectal polyp and prevention its recur, send out again, the aspect such as canceration has well
Curative effect and Research Prospects widely, but the course for the treatment of is long, and more than at least 6 months, decoction of medicinal ingredients was inconvenient, and mouthfeel is poor, little patient
Can adhere to for a long time.There is no the patent medicine of preventing and treating colorectal polyp the most both at home and abroad, pole needs this series products to plug a gap.
Bibliography:
[1] Mei Qiao, Bao Junjun, is permitted to build bright retrospective analysis [J] the Anhui medical science waiting .228 example large intestine high position adenomatous polyp,
2008；29(4): 392-394.
[2] ProMos is come. the problem [J] in the classification of colorectal polypus adenoma and diagnosis thereof. clinical and experimental pathology magazine,
2008；24 (5): 515-517.
[3] therapeutic endoscopy of the most bright coin .320 example gastrointestinal polyps and follow-up evaluation [J]. tumour, 1998；18:99
[4] high letter from home. the TCM clinical study overview [J] of colorectal polyp. modern combination of Chinese tradiational and Western medicine magazine, 2001,10 (2):
117.
[5] Liu Tianwen, Chen Yan. colorectal polyp the syndrome types of TCM the characteristic study [J]. China traditional Chinese medicine academic periodical .2010,28 (7):
1562-1564
[6] Xu Fulin. invigorating the spleen Yikang soup treatment intestinal polyp [J]. Yunnan Journal of Traditional Chinese Medicine, 1990.11 (1): 21.
[7] Ma Baihan. treatment by Chinese herbs pipe intestinal polyp 3O example [J]. the Shaanxi traditional Chinese medical science, 1991,12 (2): 58.
[8] Huang Limei, Qin little Fen. herbal enema prevention Observation on Relapse [J] after intestinal polyp enucleation. Guangxi traditional Chinese medicine,
2001,24 (2): 20.
[9] Yan little Jun, Zuo Zhengyun. the traditional Chinese medical science discussion [J] to Precancerous Lesion of Colon mechanism. Liaoning Journal of Traditional Chinese Medicine, 2007,34 (7):
905.
[10] Zhangbei County puts down, Zhao Xiying, Liu Gang. the Chinese medicine intervention study of adenomatous colorectal polyp based on " preventiveing treatment of disease " theory. in
State's general family medicine. 2012(23): 2718-2719
[11]Morson BC.Bussey HB.Management of risk for cancer in patient with
Colorectal adenomas.Br J Surg, 1985；72:23.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition preventing and treating colorectal polyp.
The technical solution used in the present invention is:
A kind of Chinese medicine composition preventing and treating colorectal polyp, its bulk drug is Radix Codonopsis, the bighead atractylodes rhizome, the Radix Astragali, the seed of Job's tears, roud cardamon seed, long-noded pit viper
Tongue grass, curcuma zedoary, pseudo-ginseng sheet and honey-fried licorice root；Preferably, the mass fraction ratio of its bulk drug is: Radix Codonopsis 12～17 parts, the bighead atractylodes rhizome 12～
17 parts, the Radix Astragali 12～17 parts, the seed of Job's tears 25～40 parts, roud cardamon seed 8～12 parts, oldenlandia diffusa 25～35 parts, curcuma zedoary 13～17 parts,
Pseudo-ginseng sheet 8～13 parts and honey-fried licorice root 2～7 parts.More preferably, the mass fraction of its bulk drug is: Radix Codonopsis 15 parts, the bighead atractylodes rhizome 15 parts, Huang
Stilbene 15 parts, the seed of Job's tears 30 parts, roud cardamon seed 10 parts, oldenlandia diffusa 30 parts, curcuma zedoary 15 parts, pseudo-ginseng sheet 10 parts and honey-fried licorice root 5 parts.
Preferably, raw material the effective elements of the medicine is its water extract.
Preferably, the formulation of Chinese medicine composition is oral agents.
A kind of preparation method preventing and treating colorectal polyp Chinese medicine composition, comprises the steps:
1) join by above-mentioned Chinese medicine composition and originally weigh Chinese medicine；
2) Chinese medicine being pulverized mixing, packing obtains Chinese medicine composition；Or use water extraction to extract the active ingredient of Chinese medicine, dry
Mix after dry and obtain Chinese medicine composition.
The invention has the beneficial effects as follows:
The Chinese medicine composition of the present invention, can be effectively improved disease after extracing adenomatous colorectal polyp patient therapy under scope, face
Bed data show, before treatment, overall average symptom integral is (3.00 ± 0.96) point, are (0.87 ± 0.62) point after treatment, and difference has
Statistical significance (=13.07, P < 0.05), after treatment, tubular adenoma, villous adenoma and mixed type adenoma patients's number of cases all subtract
Few, colorectal polyp patient clinical symptom can be effectively improved, effectively reduce the recurrence rate extracing colorectal polyp patient under scope.
Detailed description of the invention
The seed of Job's tears, Latin literary fame: Coix chinensis Tod. cries again: coix seed, the seed of jog's tears, maize, plant for grass family
The kind benevolence of thing Job's tears.
Roud cardamon seed, Latin literary fame: AIpiniatonkinensis Gagnep. is also known as Amomum cardamomum, cardamom.For Zingiber for many years
The fruit of raw herbaceous plant Amomum cardamomum, 10 ~ December, fruit was yellow green, not yet taked during cracking, and the carpopodium removing residual shines
Dry make medicinal.Take clean Amomum cardamomum, remove impurity and shell, take clean benevolence, for Amomum cardamomum benevolence, take clean Amomum cardamomum, remove impurity.
Oldenlandia diffusa (formal name used at school: Hedyotis diffusa), has another name called: HERBA HEDYOTIS DIFFUSAE, Herba Turczaninowiae Fastigiatae, Radix Picriae felterrae, for annual
Hang down loosely draft, high 15-50cm.Root is elongated, branch, spends in vain.The dry all herbal medicine of band root, tussles into bulk.
A kind of Chinese medicine composition preventing and treating colorectal polyp, its bulk drug is Radix Codonopsis, the bighead atractylodes rhizome, the Radix Astragali, the seed of Job's tears, roud cardamon seed, white
Flower HERBA HEDYOTIS DIFFUSAE, curcuma zedoary, pseudo-ginseng sheet and honey-fried licorice root；Preferably, the mass fraction ratio of its bulk drug is: Radix Codonopsis 12～17 parts, the bighead atractylodes rhizome
12～17 parts, the Radix Astragali 12～17 parts, the seed of Job's tears 25～40 parts, roud cardamon seed 8～12 parts, oldenlandia diffusa 25～35 parts, curcuma zedoary 13～
17 parts, pseudo-ginseng sheet 8～13 parts and honey-fried licorice root 2～7 parts.More preferably, the mass fraction of its bulk drug is: Radix Codonopsis 15 parts, the bighead atractylodes rhizome 15
Part, the Radix Astragali 15 parts, the seed of Job's tears 30 parts, roud cardamon seed 10 parts, oldenlandia diffusa 30 parts, curcuma zedoary 15 parts, pseudo-ginseng sheet 10 parts and honey-fried licorice root 5
Part.
Preferably, raw material the effective elements of the medicine is its water extract.Water extract
Preferably, the formulation of Chinese medicine composition is oral agents.
When taking, this Chinese medicine composition soak by water gets final product (under wherein after roud cardamon seed).Take for convenience of patient and carry,
Can be prepared into as Chinese patent drug, concrete preparation method can be as follows.
A kind of preparation method preventing and treating colorectal polyp Chinese medicine composition, comprises the steps:
1) join by above-mentioned Chinese medicine composition and originally weigh Chinese medicine；
2) Chinese medicine being pulverized mixing, packing obtains Chinese medicine composition；Or use water extraction to extract the active ingredient of Chinese medicine, dry
Mix after dry and obtain Chinese medicine composition.
For improving mouthfeel, the active ingredient that can extraction be obtained mixes with acceptable medicinal auxiliary, and preparation becomes particle
The oral formulations such as agent.
Below in conjunction with embodiment and clinical efficacy data, further illustrate technical scheme.
Embodiment 1
A kind of Chinese medicine composition preventing and treating colorectal polyp, by Radix Codonopsis 15 parts, the bighead atractylodes rhizome 15 parts, the Radix Astragali 15 parts, the seed of Job's tears 30 parts, roud cardamon seed
10 parts, oldenlandia diffusa 30 parts, curcuma zedoary 15 parts, pseudo-ginseng sheet 10 parts and honey-fried licorice root 5 parts composition；Preparation method: in weighing in proportion
Medicinal material, pulverizes, and capsule, every capsule 2g Han crude drug are made in mixing.
Embodiment 2
A kind of Chinese medicine composition preventing and treating colorectal polyp, by Radix Codonopsis 12 parts, the bighead atractylodes rhizome 14 parts, the Radix Astragali 17 parts, the seed of Job's tears 35 parts, roud cardamon seed
8 parts, oldenlandia diffusa 33 parts, curcuma zedoary 16 parts, pseudo-ginseng sheet 9 parts and honey-fried licorice root 4 parts composition.
Embodiment 3
A kind of Chinese medicine composition preventing and treating colorectal polyp, by Radix Codonopsis 14 parts, the bighead atractylodes rhizome 16 parts, the Radix Astragali 12 parts, the seed of Job's tears 40 parts, roud cardamon seed
12 parts, oldenlandia diffusa 25 parts, curcuma zedoary 13 parts, pseudo-ginseng sheet 8 parts and honey-fried licorice root 7 parts composition.
Embodiment 4
A kind of Chinese medicine composition preventing and treating colorectal polyp, by Radix Codonopsis 17 parts, the bighead atractylodes rhizome 12 parts, the Radix Astragali 14 parts, the seed of Job's tears 25 parts, roud cardamon seed
11 parts, oldenlandia diffusa 35 parts, curcuma zedoary 17 parts, pseudo-ginseng sheet 11 parts and honey-fried licorice root 5 parts composition.
Embodiment 5
A kind of Chinese medicine composition preventing and treating colorectal polyp, by Radix Codonopsis 13 parts, the bighead atractylodes rhizome 17 parts, the Radix Astragali 15 parts, the seed of Job's tears 37 parts, roud cardamon seed
10 parts, oldenlandia diffusa 30 parts, curcuma zedoary 14 parts, pseudo-ginseng sheet 13 parts and honey-fried licorice root 2 parts composition.
Clinical trial:
Inclusive criteria
(1) first diagnosis meets above colon, rectal polyp traditional Chinese and western medicine diagnostic criteria.
(2) number of polyps is less than 10 pieces, pedunculated polyp diameter < 1.2cm, sessile polyp diameter < 0.8cm.
(3) age is between 18-75 year.
1. doctor trained in Western medicine diagnosis basis: reference " practical clinical practice " (Medical Center of Fudan University writes, People's Health Publisher,
2005 the 12nd edition), " digestion mirror " (Li Yinong, Lu Xinghua chief editor, Science Press, in April, 2004 second edition) etc. guide
In one: colonoscopy finds that colon and/or rectal polyp, pathological diagnosis or chromoendoscopy are diagnosed as gland tumor-like lesion.
2. tcm diagnosis standard: according to People's Republic of China's National Diagnostic Criteria " tcm clinical practice diagnosis and treatment term disease
Part " (GB/T16751 1997), tcm diagnosis is " enteroncus " or " ovarian cyst ", " colorectal polyp ".
Exclusion standard
(1) above-mentioned Diseases of WM diagnostic criteria is not met.
(2) through proved by pathology polyp canceration.
(3) gestation or be ready for gestation women, women breast-feeding their children.
(4) the severe primary diseases such as liver, kidney, hemopoietic system, cardiopulmonary, internal system are merged.
(5) serious psychiatric patient.
Observation index
(1) morbidity and recurrence:
1. the number of adenomatous polyp: collect twice and check intestines mirror result, record the polyp number of each intestines mirror result respectively；
(2) names of disease of tcm and disease type: name of disease is with reference to National Standard of the People's Republic of China " tcm clinical practice diagnosis and treatment term "
(GB/T16751 1997)；
(3) clinical efficacy indexes:
1. general curative effect grading:
Evaluate according to twice clinical symptoms improvement situation and integral difference, symptom curative effect judging standard: recovery from illness: symptom, sign disappear
Losing or substantially disappear, symptom integration reduces 95%；Effective: symptom, sign are obviously improved, symptom integration reduces 60%；Take a turn for the better:
Symptom, sign all take a favorable turn, and symptom integration reduces 30%；Invalid: symptom, sign are not improved, symptom integration reduces deficiency
30%。
2. symptom curative effect grading: with reference to " new Chinese medicine guideline of clinical investigations " in 2002:
Stomachache:
Light: once in a while (seizure frequency is less than 3 times for 1 week)
In: often (seizure frequency 1 week 3-7 time)
Weight: continue (stomachache continues, and every day shows effect)
Times of defecation:
Light: times of defecation is less than or equal to 3 times/day or 3-4 day 1 time；
In: 3-5 times/day or 5-6 day of times of defecation is once；
Weight: times of defecation is more than or equal to 5 times/day or more than 7 days 1 time.
Have blood in stool number of times:
Light: stool is mingled with a little blood, day, number of times was less than or equal to 3 times；
In: stool mixes with blood, day number of times 4-6 time；
Weight: just blood, day, number of times was more than 6 times.
Stool:
Light: matter is the most rotten or the hardest；
In: pasty state or matter are hard；
Weight: watery stool or matter are hard such as chestnut.
Bowel habit:
Light: MC；
In: owe rule；
Weight: bowl evacuation habit seriously changes, disordered defaecation.
Note: quantify score value: asymptomatic: 0 point；Light: 1 point；In: 2 points；Weight: 3 points.Computing formula is: symptom score is poor=and controls
Integration after integration-treatment before treating.
(4) intestines mirror result
1. under twice intestines mirror, the number of adenomatous colorectal polyp compares, and calculates recurrence rate；
Statistical method
All data use SPSS17.0 statistical software to carry out entry coding, data inputting and statistical analysis.Frequency and composition are adopted
Use descriptive analysis method, between measurement data group, compare employing t inspection and variance analysis；Enumeration data uses Chi-square Test and order
And inspection.Correlation correlation analysis between each parameter.
Select April in Guangdong Provincial TCM Hospital (great virtue road Zong Yuan) 2012 September in 2010 extracing under scope of accepting for medical treatment adenomatous
Colorectal polyp patient 140 example, 18 75 years old age.According to differentiation of symptoms and signs for classification of syndrome, patient is divided into insufficiency of the spleen wet stasis of blood group (A group), dampness and heat stasis
Group (B group) and qi depression to blood stasis group (C group), often group is two subgroups further according to taking Chinese medicine, and statistics shows, subgroup
Between in terms of age, sex without significant difference.
Treatment by Chinese herbs group (A1 group) and non-treatment by Chinese herbs group (A0 group), A1 group totally 40 example, A0 group totally 36 example；
Treatment by Chinese herbs group (B1 group) and non-treatment by Chinese herbs group (B0 group), B1 group totally 22 example, B0 group totally 23 example；
Treatment by Chinese herbs group (Cl group) and non-treatment by Chinese herbs group (C0 group), C1 group totally 11 example, C0 group totally 8 example.
Treatment cycle is 6 months, checks intestines mirror after 1 year.
Treatment by Chinese herbs group takes embodiment 1 capsule, three times a day, each 8 (adding up to crude drug 16g).
Non-treatment by Chinese herbs group (control group), processing method: after giving extracing polyp under scope, do not take any preventing and treating large intestine
The Chinese medicine of polyp or Western medicine.
Efficacy experiment data:
Disease symptom score situation before and after different group treatments is as follows.
Symptom score before and after table 1 treatment
Before and after table 2 respectively organizes internal therapy, symptom score is poor
Note: * P < 0.05, result has significant difference.
As can be seen from the table, each group patient symptom after treatment is obviously improved, and before treatment, overall average symptom integral is
(3.00 ± 0.96) point, be that (0.87 ± 0.62) is divided after treatment, difference statistically significant (=13.07, P < 0.05).
Note: through Chi-square Test, Χ2< 0.05, the 140 example patients representing selected organize Chinese medicine through this for=13.07, P=0.023, P
After treatment, symptom scores is variant, and difference is statistically significant.
In each group, the recurrence of adenomatous colorectal polyp is analyzed as shown in table 3,
Table 3 respectively organizes recurrent cases number and percentage
Note: through Chi-square Test, Χ2< 0.05, difference is statistically significant for=32.62, P=0.00, P.
Through Chi-square Test, Χ2< 0.05, difference is statistically significant for=32.62, P=0.00, P.Prompting uses treatment by Chinese herbs
Group than only under scope extract group recurrence rate substantially reduce.
Spearman correlation analysis shows, adenomatous colorectal polyp number and recurrence rate be proportionate (r:0.191, P <
0.05).6 subgroup recurrence rates order from low to high is: Cl (9.1%) < A1 (12.5%) < B1 (18.2%) < A0
(30.6%) < B0 (60.9%) < CO (87.5%), minimum with insufficiency of the spleen wet stasis syndrome Patients on Recurrence rate, syndrome of qi stagnation and blood stasis patient is multiple
The rate of sending out is the highest；Each treatment by Chinese herbs subgroup recurrence rate is below the non-treatment by Chinese herbs subgroup that it is relative, and difference is the most statistically significant
(P<0.05)。
This is organized has 1 example patient that canceration occurs in 140 example patients, tubular adenoma, villous adenoma and mixed after treatment by Chinese herbs
Mould assembly adenoma patients's number of cases all reduces.Clinical laboratory data shows, the Chinese medicine composition of the present invention can be effectively improved colorectal polyp
Patient clinical symptom, effectively reduces the recurrence rate extracing colorectal polyp patient under scope.
Claims (6)
1. preventing and treating a Chinese medicine composition for colorectal polyp, its bulk drug is Radix Codonopsis, the bighead atractylodes rhizome, the Radix Astragali, the seed of Job's tears, roud cardamon seed, spends in vain
HERBA HEDYOTIS DIFFUSAE, curcuma zedoary, pseudo-ginseng sheet and honey-fried licorice root.
Chinese medicine composition the most according to claim 1, it is characterised in that: the mass fraction ratio of its bulk drug is: Radix Codonopsis 12
～17 parts, the bighead atractylodes rhizome 12～17 parts, the Radix Astragali 12～17 parts, the seed of Job's tears 25～40 parts, roud cardamon seed 8～12 parts, oldenlandia diffusa 25～35
Part, curcuma zedoary 13～17 parts, pseudo-ginseng sheet 8～13 parts and honey-fried licorice root 2～7 parts.
Chinese medicine composition the most according to claim 1, it is characterised in that: the mass fraction of its bulk drug is: Radix Codonopsis 15 parts,
The bighead atractylodes rhizome 15 parts, the Radix Astragali 15 parts, the seed of Job's tears 30 parts, roud cardamon seed 10 parts, oldenlandia diffusa 30 parts, curcuma zedoary 15 parts, pseudo-ginseng sheet 10 parts and process
5 parts of Radix Glycyrrhizae.
4. according to the Chinese medicine composition described in claims 1 to 3 any one, it is characterised in that: raw material the effective elements of the medicine is
Its water extract.
Chinese medicine composition the most according to claim 1, it is characterised in that: the formulation of Chinese medicine composition is oral agents.
6. prevent and treat a preparation method for colorectal polyp Chinese medicine composition, comprise the steps:
1) Chinese medicine composition as described in claims 1 to 3 any one weighs Chinese medicine；
2) Chinese medicine being pulverized mixing, packing obtains Chinese medicine composition；Or use water extraction to extract the active ingredient of Chinese medicine, dry
Mix after dry and obtain Chinese medicine composition.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112675223A (en) * | 2019-10-18 | 2021-04-20 | 谢岩 | Traditional Chinese medicine composition for treating multiple colon polyp, hemangioma and lipoma |
| CN114288365A (en) * | 2022-01-22 | 2022-04-08 | 周奕达 | A Chinese medicinal composition for treating polyp, and its preparation method |
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| CN103393997A (en) * | 2013-07-16 | 2013-11-20 | 怀宁县华春医院 | Traditional Chinese medicament for treating colorectal polyps and preparation method thereof |
| CN104436098A (en) * | 2014-10-27 | 2015-03-25 | 景东旭 | Traditional Chinese medicine preparation for treating multiple intestinal polyps |
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| CN103393997A (en) * | 2013-07-16 | 2013-11-20 | 怀宁县华春医院 | Traditional Chinese medicament for treating colorectal polyps and preparation method thereof |
| CN104436098A (en) * | 2014-10-27 | 2015-03-25 | 景东旭 | Traditional Chinese medicine preparation for treating multiple intestinal polyps |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112675223A (en) * | 2019-10-18 | 2021-04-20 | 谢岩 | Traditional Chinese medicine composition for treating multiple colon polyp, hemangioma and lipoma |
| CN114288365A (en) * | 2022-01-22 | 2022-04-08 | 周奕达 | A Chinese medicinal composition for treating polyp, and its preparation method |
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