CN105770532A - Medicine for treating exogenous cold and endogenous heat type cold and preparation method thereof - Google Patents
Medicine for treating exogenous cold and endogenous heat type cold and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a medicine for treating exogenous cold and endogenous heat type cold and a preparation method thereof, belonging to the technical field of medicines. The medicine comprises the following raw materials in parts by weight: 15-20 parts of commelina communis, 6-12 parts of indian bread pink epidermis, 3-9 parts of common perilla fruit, 10-18 parts of herba gerberae piloselloidis, 13-17 parts of echinopsis tubiflora, 9-15 parts of bolbitis heteroclite, 10-15 parts of serissa japonica, 6-15 parts of water shield, 2-8 parts of notholirion bulbuliferum, 6-12 parts of lily and 10-15 parts of vernonia cinerea. The medicine has the effects of opening the inhibited lung-energy and dispelling cold, clearing heat and relieving cough, regulating vital energy and soothing nerves and the like, has an obvious curative effect in treatment of exogenous cold and endogenous heat type cold, is mild in drug property and high in safety and does not have any toxic or side effect, and the cold is difficult to reoccur after curing.
Description
[technical field]
The present invention relates to pharmaceutical technology field, a kind of treat medicine of pattern of fever flu and preparation method thereof in exogenous cold.
[technical background]
Flu is a kind of the most harmful extremely common disease, and it is divided into common cold and influenza.Common cold is by multiple
A kind of respiratory tract commonly encountered diseases that virus causes, it is mainly in early winter, but any season is all likely to occur, and the sense of Various Seasonal
The Causative virus emitted is the most just the same.Influenza is the Acute respiratory infectious disease caused by influenza virus, and virus exists
In the respiratory tract of patient Yu, giving others when patient's cough, sneeze through droplet infection, influenza is typically at the machine that winter-spring season is popular
Can be more.Flu is mainly infected by virus or antibacterial and causes, and suffers from cold, drenches with rain or the risk factor such as fatigue, makes whole body or exhale
Inhale road local defense function reduce time, former be present in upper respiratory tract or from the external world invade virus or antibacterial breed rapidly, also can
Cause morbidity.Flu may cause the complication such as acute sinusitis, rhinitis, otitis media, tonsillitis, tracheitis and bronchitis,
Some patients is also possible to the diseases such as secondary rheumatism, glomerulonephritis, myocarditis.
At present, the medicine major part used by treatment flu is Western medicine, such as aspirin, acetaminophen etc., although these Western medicine
Treatment flu curative effect is fast, but long-term taking can produce toxic and side effects to human body.Chinese medicine is different with the principle of Western medicine, and Western medicine often exists
In treatment, and Chinese medicine is conditioning, and for catching a cold other symptomes complices caused and the impact on human body integrality, Chinese medicine
It is more suitable for nursing one's health comprehensively.
Flu reason of curing the disease various, in exogenous cold pattern of fever flu is a relatively conventional type, its cardinal symptom is: aversion to cold without
Antiperspirant, limb aching pain, vexed, cough out of breath, hoarseness, laryngopharynx swelling and pain, the micro-Huang of red tip of the tongue tongue, rapid pulse etc..At present, still
Without specific aim medicine of pattern of fever flu in treating exogenous cold, most is broadly to use some antibacterial, antiviral and enhancing
Immunity class medicine is treated, and some weak curative effect of these medicines, the course for the treatment of are long, and some is then cured the symptoms, not the disease, and easily recurs after healing,
Some also has certain side effect, and effect can not allow patient satisfied.
[summary of the invention]
For posed problems above, the invention provides and a kind of treat medicine of pattern of fever flu and preparation method thereof in exogenous cold, should
Medicine for treating pattern of fever flu in exogenous cold and have that effect is notable, control difficulty in relapse after healing, have no side effect, safe and reliable spy
Point.
In order to realize above-mentioned purpose, the technical solution adopted in the present invention is:
A kind for the treatment of the medicine of pattern of fever flu in exogenous cold, it includes the raw material of following weight portion: Herba Commelinae 15-20 part, Poria
6-12 part, Fructus Perillae Frutescentis 3-9 part, Herba Gerberae Piloselloidis 10-18 part, Caulis Echinopsis Multiplicis 13-17 part, Bolbitis heteroclita (Presl) Ching. 9-15 part, Serissa foetida
10-15 part, Chara fragilis Desv. 6-15 part, Bullus Notholirionis Bulbuliferi 2-8 part, Bulbus Lilii 6-12 part, Herba Vernoniae Cinereae 10-15 part.
Further, described medicine includes the raw material of following weight portion: Herba Commelinae 17-19 part, Poria 8-10 part, Fructus Perillae Frutescentis
5-7 part, Herba Gerberae Piloselloidis 12-16 part, Caulis Echinopsis Multiplicis 14-16 part, Bolbitis heteroclita (Presl) Ching. 11-13 part, Serissa foetida 12-14 part, Chara fragilis Desv.
8-12 part, Bullus Notholirionis Bulbuliferi 4-6 part, Bulbus Lilii 8-10 part, Herba Vernoniae Cinereae 12-14 part.
Further, described medicine includes the raw material of following weight portion: Herba Commelinae 18 parts, Poria 9 parts, Fructus Perillae Frutescentis 6 parts,
Herba Gerberae Piloselloidis 14 parts, Caulis Echinopsis Multiplicis 15 parts, Bolbitis heteroclita (Presl) Ching. 12 parts, Serissa foetida 13 parts, Chara fragilis Desv. 10 parts, Bullus Notholirionis Bulbuliferi 5 parts, hundred
Close 9 parts, Herba Vernoniae Cinereae 13 parts.
Further, the preparation method of described medicine comprises the following steps:
1) described raw material is picked according to above-mentioned weight portion；
2) by step 1) taken raw material clean dry after, by Herba Commelinae, Poria, Herba Gerberae Piloselloidis, Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching.,
Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi, the disconnected length that is broken to of Herba Vernoniae Cinereae, less than 1cm, then mix with Fructus Perillae Frutescentis and Bulbus Lilii, put into decoction and hold
In device, addition raw material gross weight 5-6 times and the alcohol solution dipping 30-40min that volumetric concentration is 70-80%, then reflux, extract,
2 times, each 1-2h, merge twice and extract gained filtrate, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol
Extract dry powder；The medicinal residues reservation that alcohol extraction is remaining, standby；
3) by step 2) the remaining medicinal residues of alcohol extraction add the water of raw material gross weight 3-5 times, heating and refluxing extraction 2 times,
Every time 1-2h, merges twice extracting solution, and then carries out concentrating, is dried, pulverizes, and obtains water extract dry powder；
4) by step 2) gained alcohol extraction thing dry powder and step 3) gained water extract dry powder blend is uniform, and add and pharmaceutically may be used
With the adjuvant received, make corresponding dosage form by the preparation technology of required dosage form.
Instructions of taking: each take the medicine of the present invention that effective dose is 1-2g, daily 3 times, early, middle and late after meal half
Hour decoction being taken warmly, 5 days is a course for the treatment of, and period of taking medicine withdraws other drug, and avoid eating anything raw or cold, pungent, the food that stimulates.
Chinese medicine details of the present invention is as follows:
Herba Commelinae: for the dry aerial parts of Commelianaceae plant Herba Commelinae.Sweet in the mouth, light, cold in nature.Return lung meridian, stomach warp, wing
Guang warp.There is row water heat clearing away, effect of removing pathogenic heat from blood and toxic substance from the body.Harness the river swollen, tinea pedis, dysuria, flu, erysipelas, parotitis,
Icterohepatitis, hematodiarrhoea, malaria, epistaxis, hematuria, metrorrhagia, leucorrhea, laryngopharynx swelling and pain, carbuncle furuncle." Traditional Chinese Medicine in Sichuan will ":
Energy clearing away heat and promoting diuresis, lung moistening.Controlling traumatic injury, bones and muscles pain, dribbling urination is had a pain.
Poria: for the pale red part of the dry sclerotia Jin Wai skin zone of Polyporaceae plant Poria, dry.Slightly sweet flavor, property is put down.
Enter the heart, spleen, bladder warp.There is row water, effect of dampness removing heat.Control dysuria, stranguria with turbid discharge, dysentery." book on Chinese herbal medicine is the newest ": benefit
The motive, strong neutralization spleen, lung moistening, dampness.Control dysentery.
Fructus Perillae Frutescentis: for the fruit of dicotyledon medicine labiate common perilla.Acrid in the mouth, property is put down.Return lung, stomach, large intestine channel.Tool
There are expectorant, the therapeutic method to keep the adverse QI flowing downwards, lung moistening, effect of wide intestinal.For cough with dyspnea, phlegm dyspnea, stagnation of QI constipation.
Herba Gerberae Piloselloidis: for the herb of feverfew Herba Gerberae Piloselloidis.Bitter in the mouth is pungent, and property is put down.Enter liver, lung two warp.Have heat-clearing and toxic substances removing,
Lung qi dispersing cough-relieving, effect of promoting flow of QI and blood.The main cough due to common cold, epigastric distending pain, have loose bowels, dysentery, edema, stranguria with turbid discharge, furuncle toxic swelling,
Treating swelling and pain by traumatic injury, venom." classifying herbal ": cold expelling, control cough, rheumatism." conventional glossary of Herbs and Drugs among the people "；Lung qi dispersing gas,
Diaphoresis, cold expelling pathogenic wind expelling, relieving cough and relieving asthma, only pertussis.
Caulis Echinopsis Multiplicis: for the stem of Cactaeous plants Caulis Echinopsis Multiplicis, remove the peel, sting, using fresh herb.Slightly sweet flavor, property is put down.Attach to the lung and stomach meridians.
There is effect of clearing and antitussive, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain.Control cough due to lung-heat, sputum mixed with blood, carbuncle, burn." Luchuan
Book on Chinese herbal medicine ": clear away heart-fire lung, hemostasis.Control cough due to lung-heat, sputum mixed with blood.
Bolbitis heteroclita (Presl) Ching.: for the herb of real Pteridiaceae plant Bolbitis heteroclita (Presl) Ching., dry.Lightly seasoned；Cool in nature.Return lung, liver, kidney, large intestine channel.
There is effect of clearing and antitussive, cooling blood for hemostasis.Main cough due to lung-heat, spitting of blood, dysentery, burn and scald, venom.
Serissa foetida: for Maguireothamnus speciosus Radix Serissae or the herb of Serissa foetida.Bitter in the mouth is pungent, cool in nature.Return Liver Channel；Spleen channel.Have and dispel
Wind, dampness removing, heat clearing away, effect of removing toxic substances.Dispelling the wind and dampness pathogens lumbago and skelalgia, dysentery, edema, conjunctival congestion and swelling pain, laryngalgia, toothache, women
Leucorrhea, carbuncle, scrofula." the SHENGCAO property of medicine is standby to be wanted ": cure the wound cold, heatstroke, gibberish of going mad, fire disease, also move back fever of the body." south of the Five Ridges is adopted
Medicine is recorded ": solving summer-heat, removing food stagnancy is stagnant, dysentery relieving disease；And it is cold to cure the wound, epidemic disease, carbuncle on the back skin ulcer, eliminating carbuncle cellulitis, draw out pus by applying a plaster to the affected part.
Chara fragilis Desv.: for the frond of the crisp charophyta of Characeae plant.Salty in the mouth, pungent；Property flat.Return lung meridian.Have and eliminate the phlegm, cough-relieving, relieving asthma
Effect.Main cough, abundant expectoration, uncomfortable in chest.
Bullus Notholirionis Bulbuliferi: for the bulb of liliaceous plant Bulbus Notholirionis hyacinthini, dry in the shade.Acrid in the mouth, hardship；Slightly warm in nature.Have the chest stuffiness relieving promoting the circulation of QI, stomach invigorating,
Preventing or arresting vomiting, analgesia, effect of cough-relieving.Treat for stomachache abdominal distention, uncomfortable in chest, vomit regurgitation, cough due to wind and cold, infantile convulsion.
Bulbus Lilii: for the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium.Sweet in the mouth, micro-hardship；Cold nature.Return
Heart channel；Lung meridian.There is effect of nourishing YIN and moistening the lung, cough-relieving, clearing away heart-fire for tranquillization.Control the dryness of the lung or deficiency of YIN chronic cough, cough and spit expectorant blood；Calentura
Rear waste heat comes clear, and fidgets due to deficiency is palpitated with fear, staring spells；Beriberi edema.
Herba Vernoniae Cinereae: for the herb of feverfew Herba Vernoniae Cinereae, dry.Lightly seasoned, cool in nature.There is wind-dispelling heat-dissipating, removing pathogenic heat from blood and toxic substance from the body, peace
Effect of god.For cold, fever, cough, dysentery, icterohepatitis, neurasthenia；Carbuncle furuncle and phyma poison, venom are controlled in external.
Guangzhou army " conventional Chinese herbal medicine handbook ": liver heat removing is brought down a fever, calmness of calming the nerves.Cure cold heating, cough, acute icterohepatitis,
Neurasthenia, insomnia, children's's nocturia, furuncle swelling toxin.
The invention provides and a kind of treat medicine of pattern of fever flu and preparation method thereof in exogenous cold, compared with prior art, have with
Lower beneficial effect:
In treatment exogenous cold provided by the present invention, the medicine of pattern of fever flu makes up a prescription according to the pathogenesis of pattern of fever flu in exogenous cold,
With Herba Commelinae, Poria, Fructus Perillae Frutescentis, Herba Gerberae Piloselloidis, Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching., Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi, Bulbus Lilii,
Herba Vernoniae Cinereae is primary raw material, and wherein Herba Commelinae, Poria, Fructus Perillae Frutescentis, Herba Gerberae Piloselloidis have the effects such as lung qi dispersing cold expelling, invigorating the spleen and benefiting QI；
Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching., Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi can heat-clearing and toxic substances removing, relieving cough and asthma, expelling wind and removing dampness；Herba Vernoniae Cinereae, hundred
Conjunction can nourishing the liver, clear away heart-fire, calm the nerves.The most all medicine compatibilities, bring out the best in each other, and plays lung qi dispersing cold expelling, clearing and antitussive altogether, regulates the flow of vital energy and calm the nerves
Effect, can fundamentally treat pattern of fever flu in exogenous cold, evident in efficacy, controls difficulty in relapse after healing, and the property of medicine is gentle, and nontoxic pair
Effect, safe and reliable.
[detailed description of the invention]
The following examples can help those skilled in the art to be more completely understood by the present invention, but cannot limit by any way
The present invention processed.
Embodiment 1
A kind for the treatment of the medicine of pattern of fever flu in exogenous cold, it includes the raw material of following weight portion: Herba Commelinae 15 parts, Poria 6 parts,
Fructus Perillae Frutescentis 3 parts, Herba Gerberae Piloselloidis 10 parts, Caulis Echinopsis Multiplicis 13 parts, Bolbitis heteroclita (Presl) Ching. 9 parts, Serissa foetida 10 parts, Chara fragilis Desv. 6 parts, the whitest
2 parts of rice, Bulbus Lilii 6 parts, Herba Vernoniae Cinereae 10 parts.Concrete preparation method comprises the following steps:
1) described raw material is picked according to above-mentioned weight portion；
2) by step 1) taken raw material clean dry after, by Herba Commelinae, Poria, Herba Gerberae Piloselloidis, Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching.,
Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi, the disconnected length that is broken to of Herba Vernoniae Cinereae, less than 1cm, then mix with Fructus Perillae Frutescentis and Bulbus Lilii, put into decoction and hold
In device, addition raw material gross weight 5 times and the alcohol solution dipping 30min that volumetric concentration is 70%, then reflux, extract, 2 times, often
Secondary 2h, merges twice and extracts gained filtrate, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry powder；
The medicinal residues reservation that alcohol extraction is remaining, standby；
3) by step 2) the remaining medicinal residues of alcohol extraction add the water of raw material gross weight 3 times, heating and refluxing extraction 2 times, often
Secondary 1h, merges twice extracting solution, and then carries out concentrating, is dried, pulverizes, and obtains water extract dry powder；
4) by step 2) gained alcohol extraction thing dry powder and step 3) gained water extract dry powder blend is uniform, and add and pharmaceutically may be used
With the adjuvant received, make corresponding dosage form by the preparation technology of required dosage form.
Embodiment 2
A kind for the treatment of the medicine of pattern of fever flu in exogenous cold, it includes the raw material of following weight portion: Herba Commelinae 17 parts, Poria 8 parts,
Fructus Perillae Frutescentis 5 parts, Herba Gerberae Piloselloidis 12 parts, Caulis Echinopsis Multiplicis 14 parts, Bolbitis heteroclita (Presl) Ching. 11 parts, Serissa foetida 12 parts, Chara fragilis Desv. 8 parts, too
Rice 4 parts, Bulbus Lilii 8 parts, Herba Vernoniae Cinereae 12 parts.Concrete preparation method comprises the following steps:
1) described raw material is picked according to above-mentioned weight portion；
2) by step 1) taken raw material clean dry after, by Herba Commelinae, Poria, Herba Gerberae Piloselloidis, Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching.,
Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi, the disconnected length that is broken to of Herba Vernoniae Cinereae, less than 1cm, then mix with Fructus Perillae Frutescentis and Bulbus Lilii, put into decoction and hold
In device, addition raw material gross weight 5 times and the alcohol solution dipping 30min that volumetric concentration is 80%, then reflux, extract, 2 times, often
Secondary 1h, merges twice and extracts gained filtrate, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry powder；
The medicinal residues reservation that alcohol extraction is remaining, standby；
3) by step 2) the remaining medicinal residues of alcohol extraction add the water of raw material gross weight 3 times, heating and refluxing extraction 2 times, often
Secondary 1h, merges twice extracting solution, and then carries out concentrating, is dried, pulverizes, and obtains water extract dry powder；
4) by step 2) gained alcohol extraction thing dry powder and step 3) gained water extract dry powder blend is uniform, and add and pharmaceutically may be used
With the adjuvant received, make corresponding dosage form by the preparation technology of required dosage form.
Embodiment 3
A kind for the treatment of the medicine of pattern of fever flu in exogenous cold, it includes the raw material of following weight portion: Herba Commelinae 18 parts, Poria 9 parts,
Fructus Perillae Frutescentis 6 parts, Herba Gerberae Piloselloidis 14 parts, Caulis Echinopsis Multiplicis 15 parts, Bolbitis heteroclita (Presl) Ching. 12 parts, Serissa foetida 13 parts, Chara fragilis Desv. 10 parts, too
Rice 5 parts, Bulbus Lilii 9 parts, Herba Vernoniae Cinereae 13 parts.Concrete preparation method comprises the following steps:
1) described raw material is picked according to above-mentioned weight portion；
2) by step 1) taken raw material clean dry after, by Herba Commelinae, Poria, Herba Gerberae Piloselloidis, Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching.,
Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi, the disconnected length that is broken to of Herba Vernoniae Cinereae, less than 1cm, then mix with Fructus Perillae Frutescentis and Bulbus Lilii, put into decoction and hold
In device, addition raw material gross weight 5 times and the alcohol solution dipping 35min that volumetric concentration is 75%, then reflux, extract, 2 times, often
Secondary 2h, merges twice and extracts gained filtrate, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry powder；
The medicinal residues reservation that alcohol extraction is remaining, standby；
3) by step 2) the remaining medicinal residues of alcohol extraction add the water of raw material gross weight 4 times, heating and refluxing extraction 2 times, often
Secondary 2h, merges twice extracting solution, and then carries out concentrating, is dried, pulverizes, and obtains water extract dry powder；
4) by step 2) gained alcohol extraction thing dry powder and step 3) gained water extract dry powder blend is uniform, and add and pharmaceutically may be used
With the adjuvant received, make corresponding dosage form by the preparation technology of required dosage form.
Embodiment 4
A kind of treat the medicine of pattern of fever flu in exogenous cold, it include the raw material Herba Commelinae 19 parts of following weight portion, Poria 10 parts,
Fructus Perillae Frutescentis 7 parts, Herba Gerberae Piloselloidis 16 parts, Caulis Echinopsis Multiplicis 16 parts, Bolbitis heteroclita (Presl) Ching. 13 parts, Serissa foetida 14 parts, Chara fragilis Desv. 12 parts, too
Rice 6 parts, Bulbus Lilii 10 parts, Herba Vernoniae Cinereae 14 parts.Concrete preparation method comprises the following steps:
1) described raw material is picked according to above-mentioned weight portion；
2) by step 1) taken raw material clean dry after, by Herba Commelinae, Poria, Herba Gerberae Piloselloidis, Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching.,
Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi, the disconnected length that is broken to of Herba Vernoniae Cinereae, less than 1cm, then mix with Fructus Perillae Frutescentis and Bulbus Lilii, put into decoction and hold
In device, addition raw material gross weight 6 times and the alcohol solution dipping 40min that volumetric concentration is 70%, then reflux, extract, 2 times, often
Secondary 1.5h, merges twice and extracts gained filtrate, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry
Powder；The medicinal residues reservation that alcohol extraction is remaining, standby；
3) by step 2) the remaining medicinal residues of alcohol extraction add the water of raw material gross weight 5 times, heating and refluxing extraction 2 times, often
Secondary 1.5h, merges twice extracting solution, and then carries out concentrating, is dried, pulverizes, and obtains water extract dry powder；
4) by step 2) gained alcohol extraction thing dry powder and step 3) gained water extract dry powder blend is uniform, and add and pharmaceutically may be used
With the adjuvant received, make corresponding dosage form by the preparation technology of required dosage form.
Embodiment 5
A kind for the treatment of the medicine of pattern of fever flu in exogenous cold, it includes the raw material of following weight portion: Herba Commelinae 20 parts, Poria 12
Part, Fructus Perillae Frutescentis 9 parts, Herba Gerberae Piloselloidis 18 parts, Caulis Echinopsis Multiplicis 17 parts, Bolbitis heteroclita (Presl) Ching. 15 parts, Serissa foetida 15 parts, Chara fragilis Desv. 15 parts,
Bullus Notholirionis Bulbuliferi 8 parts, Bulbus Lilii 12 parts, Herba Vernoniae Cinereae 15 parts.Concrete preparation method comprises the following steps:
1) described raw material is picked according to above-mentioned weight portion；
2) by step 1) taken raw material clean dry after, by Herba Commelinae, Poria, Herba Gerberae Piloselloidis, Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching.,
Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi, the disconnected length that is broken to of Herba Vernoniae Cinereae, less than 1cm, then mix with Fructus Perillae Frutescentis and Bulbus Lilii, put into decoction and hold
In device, addition raw material gross weight 6 times and the alcohol solution dipping 30min that volumetric concentration is 80%, then reflux, extract, 2 times, often
Secondary 2h, merges twice and extracts gained filtrate, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol extraction thing dry powder；
The medicinal residues reservation that alcohol extraction is remaining, standby；
3) by step 2) the remaining medicinal residues of alcohol extraction add the water of raw material gross weight 5 times, heating and refluxing extraction 2 times, often
Secondary 2h, merges twice extracting solution, and then carries out concentrating, is dried, pulverizes, and obtains water extract dry powder；
4) by step 2) gained alcohol extraction thing dry powder and step 3) gained water extract dry powder blend is uniform, and add and pharmaceutically may be used
With the adjuvant received, make corresponding dosage form by the preparation technology of required dosage form.
Clinical observation statistics
1, the object of observation:
In selecting the exogenous cold made a definite diagnosis, pattern of fever cold patients 300 example carries out clinical observation, and cardinal symptom has: aversion to cold is lossless, limbs acid
Bitterly, vexed, cough out of breath, hoarseness, laryngopharynx swelling and pain, the micro-Huang of red tip of the tongue tongue, rapid pulse etc..It is randomly divided into treatment group and right
According to group, treatment group 150 example, wherein male 74 example, women 76 example, age 14-58 year；Matched group 150 example, wherein,
Male 75 example, women 75 example, age 15-58 year.Treatment group and the sex of two groups of cases of matched group, age, the state of an illness are basic
Unanimously, without significant difference, there is comparability.
2, Therapeutic Method
Treatment group: medicine of the present invention for oral administration, three times a day, each takes the medicine that effective dose is 1-2g, early, middle and late meal
Half an hour after decoction being taken warmly, 5 days is a course for the treatment of, observes after taking 1-3 the course for the treatment of, and period of taking medicine withdraws other drug, and
Avoid eating anything raw or cold, pungent, stimulate food.
Matched group: the medicine (such as aspirin, acetaminophen etc.) of pattern of fever flu in the oral treatment exogenous cold bought on the market,
Taking according to taking explanation, carry out Synchronous with treatment group, period of taking medicine withdraws other drug, and avoid eating anything raw or cold, pungent,
The food stimulated.
4, treatment standard
Cure: the various transference cures of pattern of fever flu in exogenous cold；Effective: in exogenous cold, pattern of fever cold symptoms substantially alleviates；Invalid:
After medication, in the exogenous cold of patient, pattern of fever cold symptoms has no improvement.
5, therapeutic outcome
Treatment group and matched group clinical treatment outcome are as shown in table 1:
Table 1 treatment group and matched group clinical treatment outcome
| n | Recovery from illness | Effectively | Invalid | Total effective rate (%) | |
| Treatment group | 150 | 64 | 70 | 16 | 89.4 |
| Matched group | 150 | 37 | 69 | 44 | 70.7 |
By the clinical treatment outcome of upper table 1 treatment group and matched group it can be seen that treatment group 150 example, take outside the present invention treats
In cold after 1-3 the course for the treatment of of medicine of pattern of fever flu, curing 64 examples (accounting for sum 42.7%), effective 70 examples (account for total 46.7%),
Invalid 16 examples, total effective rate is 89.4%；Matched group 150 example, takes pattern of fever cold medicine in presently commercially available treatment exogenous cold,
Synchronization carrying out observing with treatment group, cure 37 examples (accounting for sum 24.7%), effective 69 examples (account for sum 46.0%), invalid
46 examples, total effective rate is 70.7%；Visible, in medicine of the present invention is used for treating exogenous cold, pattern of fever flu effect is substantially better than matched group
Marketed drugs, cure rate is high.
Although, the present invention is described in detail the most with a general description of the specific embodiments, but in the present invention
On the basis of, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore, not
Deviate these modifications or improvements on the basis of spirit of the present invention, belong to the scope of protection of present invention.
Claims (4)
1. treat the medicine of pattern of fever flu in exogenous cold for one kind, it is characterised in that described medicine includes the raw material of following weight portion: the duck sole of the foot
Grass 15-20 part, Poria 6-12 part, Fructus Perillae Frutescentis 3-9 part, Herba Gerberae Piloselloidis 10-18 part, Caulis Echinopsis Multiplicis 13-17 part, come into leaves reality
Herba pteridii latiusculi 9-15 part, Serissa foetida 10-15 part, Chara fragilis Desv. 6-15 part, Bullus Notholirionis Bulbuliferi 2-8 part, Bulbus Lilii 6-12 part, Herba Vernoniae Cinereae 10-15 part.
2. the medicine of pattern of fever flu in treatment exogenous cold as claimed in claim 1, it is characterised in that described medicine includes following weight
The raw material of part: Herba Commelinae 17-19 part, Poria 8-10 part, Fructus Perillae Frutescentis 5-7 part, Herba Gerberae Piloselloidis 12-16 part, Caulis Echinopsis Multiplicis
14-16 part, Bolbitis heteroclita (Presl) Ching. 11-13 part, Serissa foetida 12-14 part, Chara fragilis Desv. 8-12 part, Bullus Notholirionis Bulbuliferi 4-6 part, Bulbus Lilii 8-10
Part, Herba Vernoniae Cinereae 12-14 part.
3. the medicine of pattern of fever flu in treatment exogenous cold as claimed in claim 2, it is characterised in that described medicine includes following weight
Part raw material: Herba Commelinae 18 parts, Poria 9 parts, Fructus Perillae Frutescentis 6 parts, Herba Gerberae Piloselloidis 14 parts, Caulis Echinopsis Multiplicis 15 parts, come into leaves reality
Herba pteridii latiusculi 12 parts, Serissa foetida 13 parts, Chara fragilis Desv. 10 parts, Bullus Notholirionis Bulbuliferi 5 parts, Bulbus Lilii 9 parts, Herba Vernoniae Cinereae 13 parts.
4. the preparation method of the medicine of pattern of fever flu in the treatment exogenous cold as described in claim 1-3 is arbitrary, it is characterised in that described
Preparation method comprises the following steps:
1) described raw material is picked according to above-mentioned weight portion；
2) by step 1) taken raw material clean dry after, by Herba Commelinae, Poria, Herba Gerberae Piloselloidis, Caulis Echinopsis Multiplicis, Bolbitis heteroclita (Presl) Ching.,
Serissa foetida, Chara fragilis Desv., Bullus Notholirionis Bulbuliferi, the disconnected length that is broken to of Herba Vernoniae Cinereae, less than 1cm, then mix with Fructus Perillae Frutescentis and Bulbus Lilii, put into decoction and hold
In device, addition raw material gross weight 5-6 times and the alcohol solution dipping 30-40min that volumetric concentration is 70-80%, then reflux, extract,
2 times, each 1-2h, merge twice and extract gained filtrate, decompression recycling ethanol, then carry out concentrating, be dried, pulverize, obtain alcohol
Extract dry powder；The medicinal residues reservation that alcohol extraction is remaining, standby；
3) by step 2) the remaining medicinal residues of alcohol extraction add the water of raw material gross weight 3-5 times, heating and refluxing extraction 2 times,
Every time 1-2h, merges twice extracting solution, and then carries out concentrating, is dried, pulverizes, and obtains water extract dry powder；
4) by step 2) gained alcohol extraction thing dry powder and step 3) gained water extract dry powder blend is uniform, and add and pharmaceutically may be used
With the adjuvant received, make corresponding dosage form by the preparation technology of required dosage form.
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Citations (3)
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|---|---|---|---|---|
| CN101301446A (en) * | 2008-06-06 | 2008-11-12 | 王丽城 | Oral Chinese medicine for treating cough due to pathogenic wind-cold |
| CN102580042A (en) * | 2012-03-20 | 2012-07-18 | 河南九势制药股份有限公司 | Traditional Chinese medicine composition for treating wind-cold type of common cold and preparation method of traditional Chinese medicine composition |
| CN105396039A (en) * | 2015-12-15 | 2016-03-16 | 叶宗耀 | Pharmaceutical composition preventing children from repeated cold and preparation method therefor |
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2016
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|---|---|---|---|---|
| CN101301446A (en) * | 2008-06-06 | 2008-11-12 | 王丽城 | Oral Chinese medicine for treating cough due to pathogenic wind-cold |
| CN102580042A (en) * | 2012-03-20 | 2012-07-18 | 河南九势制药股份有限公司 | Traditional Chinese medicine composition for treating wind-cold type of common cold and preparation method of traditional Chinese medicine composition |
| CN105396039A (en) * | 2015-12-15 | 2016-03-16 | 叶宗耀 | Pharmaceutical composition preventing children from repeated cold and preparation method therefor |
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| 吴幸周: "藿香正气散治疗感冒挟湿的临床研究", 《中国博士学位论文全文数据库 医药卫生科技辑》 * |
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