CN105769594A - Cosmetic for treating small-area leucoderma - Google Patents
Cosmetic for treating small-area leucoderma Download PDFInfo
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- CN105769594A CN105769594A CN201410828082.9A CN201410828082A CN105769594A CN 105769594 A CN105769594 A CN 105769594A CN 201410828082 A CN201410828082 A CN 201410828082A CN 105769594 A CN105769594 A CN 105769594A
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Abstract
The invention discloses a cosmetic for treating small-area leucoderma and relates to the field of medicinal cosmetics.The cosmetic is prepared from dimethyl fumarate and moisturizer.The moisturizer is prepared from Vaseline and glycerinum.Small-area leucoderma can be effectively treated, aiming at generalized leucoderma, the immunity of a patient can be adjusted in cooperation with oral medicine, no corticosteroid hormone is contained, the side effects of skin acne, epifolliculitis, hairiness, even atrophoderma and the like caused by long use of hormone ointment are effectively avoided, and the cosmetic is suitable for wide leucoderma patients.The cosmetic has the advantages of being easy to prepare, stable in property, convenient to use, good in treatment effect, low in cost and free of obvious side effect, holding moisture, moistening skin and the like.
Description
Technical field
The invention belongs to cosmetic field, relate to a kind of cosmeceutical, treat the leukodermic cosmetics of little area more particularly to one.
Background technology
Vitiligo is a kind of common idiopathic local skin dyschromicum dermatosis, the traditional Chinese medical science is called " leucoderma " or " vitiligo ", due to local skin pigment obstacle, the hypofunction of cheese ammonia enzyme system in the melanocyte of skin and hair follicle, cause epidermis substantially to lack melanocyte, skin pigment depigmentation is made to cause, may occur in which the circle differed in size or oval white macula, sharpness of border on skin, edge pigment is deeper, apart from skin, eye, ear etc. can also be involved.This disease no conscious sympton, the course of disease slowly is difficult to cure, though not threat to life, but it is exposed to the position such as face, cervical region, have a strong impact on beauty treatment, patient is caused great psychic pain.
Treat leukodermic medicine at present, cosmetics a lot, but all do not reach and effectively effect a radical cure effect, though most patient is through treatment depigmentation not further expansion, but white macula is difficult to disappear.Such as, the following formula about activity of tyrosinase: patent of invention CN102430059B discloses a kind of leukodermic outer wiping Chinese medicine composition for the treatment of being made up of Rhizoma Gastrodiae extract, Fructus Luffae (fresh) extract, Semen Phaseoli extract, Spica Prunellae extract, Semen Raphani extract；Patent of invention ZL200910306893.1 discloses the leukodermic outer wiping Chinese medicine composition of a kind for the treatment of being made up of Radix Polygoni Multiflori, Fructus Atriplicis Sibiricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Flos Carthami, Caulis Spatholobi, the Radix Angelicae Dahuricae, Semen Sesami Nigrum, Fructus Psoraleae, Testa sojae atricolor；Patent of invention CN101623330 discloses a kind of leukodermic outer wiping Chinese medicine composition for the treatment of being made up of Fructus Psoraleae, Fructus Atriplicis Sibiricae, Radix Saposhnikoviae, common fig leaf juice (fresh)；Patent of invention CN101502577 discloses the leukodermic Chinese medicine external medicinal liquid of a kind for the treatment of being made up of Fructus Mume, Semen Cuscutae, Fructus Psoraleae, Flos Carthami.The externally applied liniment of above-mentioned Chinese medicine formula has certain effect for treatment vitiligo, but the course for the treatment of is oversize, and owing to the reason of each side causes that this sick relapse rate is higher after treatment.
By volunteer's wipings of 6 years experiment on probation, the present inventor uses the present invention to treat little area vitiligo 622 example, achieves good effect.
Summary of the invention
The technical problem to be solved is to overcome the deficiencies in the prior art, it is provided that one treats the leukodermic cosmetics of little area.These cosmetics are except can except water conservation skin protection, it may also be used for treat little area vitiligo, beautifying skin；It has use safety, stable in properties, the feature such as good effect, short treating period.
To achieve these goals, the present invention is achieved by the following technical solutions:
One treats the leukodermic cosmetics of little area, and its raw material consists of dimethyl fumarate and emollient cream.
Described dimethyl fumarate is the cosmetic treatment leukodermic key component of little area of the present invention；Described emollient cream is made up of vaseline and glycerol, is the matrix components of the cosmetics of the present invention.
The raw material of the leukodermic cosmetics of the little area of described treatment, counts by weight ratio, and composition includes: dimethyl fumarate 30%～40%, emollient cream 60～70%；Wherein emollient cream includes vaseline 10～60%, glycerol 10～60%.
Preferably, the raw material of the leukodermic cosmetics of the little area of described treatment, to count by weight ratio, composition includes: dimethyl fumarate 30%, emollient cream 70%；Wherein emollient cream includes vaseline 10～60%, glycerol 10～60%.
Preferably, the raw material of the leukodermic cosmetics of the little area of described treatment, to count by weight ratio, composition includes: dimethyl fumarate 40%, emollient cream 60%；Wherein emollient cream includes vaseline 10～50%, glycerol 10～50%.
Preferably, the raw material of the leukodermic cosmetics of the little area of described treatment, to count by weight ratio, composition includes: dimethyl fumarate 35%, emollient cream 65%；Wherein emollient cream includes vaseline 25～35%, glycerol 30～40%.
Preferably, the raw material of the leukodermic cosmetics of the little area of described treatment, to count by weight ratio, composition includes: dimethyl fumarate 35%, emollient cream 65%；Wherein emollient cream includes vaseline 30%, glycerol 35%.
The preparation method of the leukodermic cosmetics of the little area of described treatment, specifically includes following steps:
(1) weighing glycerol and vaseline by weight ratio respectively, both successively added in containers, heating is to 80～100 DEG C, and stirring makes it be completely melt, mixes, and is cooled to 60～70 DEG C, obtains skin moistening base fluid, standby；
(2) weigh dimethyl fumarate by weight ratio, be slowly added in above-mentioned skin moistening base fluid, and stirring makes it mix, control temperature to 28-32 DEG C, when starting to precipitate out white little crystal grain in beaker, stop heating, continue stirring, making its natural cooling, obtain white paste, this paste is gained.
The leukodermic cosmetics of the little area of described treatment, are exclusively used in treatment the suffered from white spot area of the patient leukodermic liniment less than body surface area 10 ‰ for a kind of.During for treating large area vitiligo, pain or pain aggravation can be produced.
The leukodermic mechanism of action of cosmetic treatment of the present invention:
The main active dimethyl fumarate of the present invention penetrates the cell membrane of the dysfunction melanocyte at affected skin tissue place smoothly with molecularity, enter in cell, by contacting and stifling double route suppresses cell division effectively, and by the suppression of tricarboxylic acid cycle (TCAC) hexosephosphate approach (HMP) and the enzymatic activity of diphosphate pathway (EMP) is destroyed cellular respiration, so that dysfunction melanocyte is effectively controlled, eliminates, reach to treat leukodermic purpose.
The invention has the beneficial effects as follows:
(1) the present invention can effectively treat little area vitiligo, to general property vitiligo, endo-medicine can be coordinated to regulate the immunologic function of patient, be suitable for vast patients with vitiligo；Have the effect of water conservation skin moistening concurrently.
(2) the present invention has the features such as preparation simple, stable in properties, easy to use, low, the non-evident effect of good effect, cost.
(3) the present invention is without corticosteroid hormone, is prevented effectively from the skin acne caused by life-time service hormones ointment, folliculitis, hirsutism, even the side effect such as atrophoderma.
Detailed description of the invention
In conjunction with the embodiments and experimental example further the present invention is set forth, be not construed as limiting the invention.
Embodiment 1
One treats the leukodermic cosmetics of little area, and its raw material consists of: horse dimethyl phthalate 30g, emollient cream 70g；Wherein emollient cream includes vaseline 30g, glycerol 40g.
The preparation method of the leukodermic cosmetics of the little area of above-mentioned treatment is:
(1) weighing glycerol 40g and vaseline 30g respectively, successively add in container, heating is to 85 DEG C, and stirring makes it be completely melt, mixes, and is cooled to 60 DEG C, obtains skin moistening base fluid, standby；
(2) weigh dimethyl fumarate 30g, be slowly added in above-mentioned skin moistening base fluid, and stirring makes it mix, control temperature to 28 DEG C, when starting to precipitate out white little crystal grain in beaker, stop heating, continue to stir so that it is natural cooling, obtain white paste,.
Embodiment 2
One treats the leukodermic cosmetics of little area, and its raw material consists of: horse dimethyl phthalate 40g, emollient cream 60g；Wherein emollient cream includes vaseline 30g, glycerol 30g.
The preparation method of the leukodermic cosmetics of the little area of above-mentioned treatment is:
(1) weighing glycerol 30g and vaseline 30g respectively, successively add in container, heating is to 100 DEG C, and stirring makes it be completely melt, mixes, and is cooled to 70 DEG C, obtains skin moistening base fluid, standby；
(2) weigh dimethyl fumarate 40g, be slowly added in above-mentioned skin moistening base fluid, and stirring makes it mix, control temperature to 30 DEG C, when starting to precipitate out white little crystal grain in beaker, stop heating, continue to stir so that it is natural cooling, obtain white paste,.
Experimental example
This invention carries out wiping experiment on probation, and accepting patient is all little area (white spot area accounts for body surface area less than 10 ‰) vitiligo volunteer, totally 622 example, 15～50 years old age, average 25 years old, course of disease January to 10 years, average 5.6 years.Without gestation and women breast-feeding their children, without serious cardiopulmonary hepatorenal disease and tumor patient, without to photaesthesia patient.In volunteer equal January, system does not use oral medicine, has not used medicine for external use in March.
Arranging patient cases's data, 622 examples are divided into 2 groups, namely male patient organizes A and female patient group B, then is respectively divided into two groups by pathological changes happening part, i.e. head generating region group (A1, B1) and trunk generating region group (A2, B2)；Head generating region includes the position such as face, neck, and trunk generating region includes the regions such as extremity, back, chest.Concrete Therapeutic Method, curative effect etc. are as shown in the table in detail:
Analysis test result indicate that:
1, all patients are all had good therapeutic effect, average cure rate to be 88.7% by the present invention, and wherein the average cure rate of male patient's (A group) is 88.4%, and the average cure rate of female patient (B group) is 89.0%.
2, all there are good therapeutic effect, average cure rate in all sufferer places by the present invention is 88.7%, and wherein the average cure rate of head generating region (A1, B1) is 88.1%, and the average cure rate of trunk generating region is 89.3%.
3, the embodiment that the present invention selects all has good therapeutic effect, average cure rate to be 88.7%, and wherein the average cure rate of embodiment 1 is 87.8%, and the average cure rate of embodiment 2 is 89.6%.
4, embodiment 1 selected in above-mentioned experiment is containing effective therapeutic component 30%, embodiment 2 is containing effective therapeutic component 40%, both of which can effectively treat little area vitiligo, illustrates, when in the cosmetics of the present invention containing effective therapeutic component 30%～40%, all can effectively treat little area vitiligo.
During treating, note rational diet.All patients, when treatment or after treatment, all do not find obvious toxic-side effects.Follow up a case by regular visits to healing patient, do not find recidivist.
Claims (8)
1. the treatment leukodermic cosmetics of little area, it is characterised in that: raw material composition includes: dimethyl fumarate and emollient cream, wherein emollient cream is made up of vaseline and glycerol.
2. one as claimed in claim 1 treats the leukodermic cosmetics of little area, it is characterised in that: described raw material is counted by weight ratio, specifically includes: dimethyl fumarate 30%～40%, emollient cream 60～70%；Wherein emollient cream includes vaseline 10～60%, glycerol 10～60%.
3. one as claimed in claim 1 treats the leukodermic cosmetics of little area, it is characterised in that: described raw material is counted by weight ratio, specifically includes: dimethyl fumarate 30%, emollient cream 70%；Wherein emollient cream includes vaseline 10～60%, glycerol 10～60%.
4. one as claimed in claim 1 treats the leukodermic cosmetics of little area, it is characterised in that: described raw material is counted by weight ratio, specifically includes: dimethyl fumarate 40%, emollient cream 60%；Wherein emollient cream includes vaseline 10～50%, glycerol 10～50%.
5. one as claimed in claim 1 treats the leukodermic cosmetics of little area, it is characterised in that: described raw material is counted by weight ratio, specifically includes: dimethyl fumarate 35%, emollient cream 65%；Wherein emollient cream includes vaseline 25～35%, glycerol 30～40%.
6. one as claimed in claim 1 treats the leukodermic cosmetics of little area, it is characterised in that: described raw material is counted by weight ratio, specifically includes: dimethyl fumarate 35%, emollient cream 65%；Wherein emollient cream includes vaseline 30%, glycerol 35%.
7. a kind of preparation method treating the leukodermic cosmetics of little area as claimed in claim 1, it is characterised in that: specifically include following steps:
(1) weighing glycerol and vaseline by weight ratio respectively, both successively added in containers, heating is to 80～100 DEG C, and stirring makes it be completely melt, mixes, and is cooled to 60～70 DEG C, obtains skin moistening base fluid, standby；
(2) weigh dimethyl fumarate by weight ratio, be slowly added in above-mentioned skin moistening base fluid, and stirring makes it mix, control temperature to 28-32 DEG C, when starting to precipitate out white little crystal grain in beaker, stop heating, continue stirring, making its natural cooling, obtain white paste, this paste is gained.
8. one as claimed in claim 1 treats the leukodermic cosmetics of little area, it is characterised in that: described cosmetics are exclusively used in treatment the suffered from white spot area of the patient vitiligo less than body surface area 10 ‰.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410828082.9A CN105769594A (en) | 2014-12-26 | 2014-12-26 | Cosmetic for treating small-area leucoderma |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410828082.9A CN105769594A (en) | 2014-12-26 | 2014-12-26 | Cosmetic for treating small-area leucoderma |
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| CN105769594A true CN105769594A (en) | 2016-07-20 |
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| CN201410828082.9A Pending CN105769594A (en) | 2014-12-26 | 2014-12-26 | Cosmetic for treating small-area leucoderma |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017137576A1 (en) * | 2016-02-12 | 2017-08-17 | Universität Zürich | Dimethyl fumarate (dmf) for prevention or treatment of gout, acne, diabetes, vitiligo and/or pyoderma gangrenosum |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188832A (en) * | 2014-07-22 | 2014-12-10 | 高小娜 | Vaseline skin moisturizing cream |
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2014
- 2014-12-26 CN CN201410828082.9A patent/CN105769594A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188832A (en) * | 2014-07-22 | 2014-12-10 | 高小娜 | Vaseline skin moisturizing cream |
Non-Patent Citations (2)
| Title |
|---|
| 中国农业科学员饲料研究所: "《中国饲料原料采购指南》", 31 July 2002, 企业管理出版社 * |
| 邹志飞: "《食品添加剂使用标准之解读》", 30 September 2011, 中国标准出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017137576A1 (en) * | 2016-02-12 | 2017-08-17 | Universität Zürich | Dimethyl fumarate (dmf) for prevention or treatment of gout, acne, diabetes, vitiligo and/or pyoderma gangrenosum |
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Application publication date: 20160720 |
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