CN105767531A - Feed additive and feed - Google Patents
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- CN105767531A CN105767531A CN201610161081.2A CN201610161081A CN105767531A CN 105767531 A CN105767531 A CN 105767531A CN 201610161081 A CN201610161081 A CN 201610161081A CN 105767531 A CN105767531 A CN 105767531A
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Abstract
The invention provides a feed additive. The feed additive comprises a Houttuyfonate homologen shown in the formula (I). The Houttuyfonate homologen provided by the invention is used as a feed additive which has the functions of replacing feed antibiotics, regulating immunity, resisting bacteria and viruses as well as preventing animal diarrhea and disease occurrence. The invention further provides a feed; and the feed comprises the feed additive and accessory ingredients.
Description
Technical field
The present invention relates to field of feed, particularly relate to a kind of feed additive and a kind of feedstuff.
Background technology
Houttuynine sodium bisulfite is decanoylacetaldehyde, and it is the main active ingredient of saururaceae plant houttuynia cordata (being commonly called as Herba Houttuyniae).
Decanoylacetaldehyde is very unstable, reacts the metastable decanoylacetaldehyde sodium hydrosulfite of generation with sodium sulfite.Synthesized again lauroyl acetaldehyde sulfurous hydracid sodium later, it is referred to as neo-houttuyninum, both of which has effect of antibacterial, antiviral, antipyretic, town pain, antiinflammatory and antitussive, notable loose intestinal smooth, several functions diarrhoea can be treated, in the past few decades, it is applied to field of medicaments, for treating some disease of the mankind always.
But above-mentioned substance nature is unstable, easily it is polymerized, sensitization is often had to occur, secondly because this kind of material dissolubility in water is little, even indissoluble or insoluble, injection production technology adds the Tween 80 solubilising of several times of tens times amount, and tween 80 has haemolysis, and aquatic animal is had overt toxicity.
Clinical medicine application Herba Houttuyniae injectio is likely to occur anaphylactic shock, systemic anaphylaxis, uncomfortable in chest, cardiopalmus, dyspnea, serious symptom rash, even dead.Ending on May 31st, 2006, untoward reaction case report has reached 5000 unnecessary examples, within 6th, discloses " about 7 injections such as Herba Houttuyniae injectio about processing the notice determined " in JIUYUE in 2006.
Sodium New Houttuyfonate is easy to polyreaction, generates the neo-houttuyninum dimer with formula (II) structure, has the trimer of the neo-houttuyninum of formula (III) structure；
Above-mentioned substance is had good inhibition by polymerization inhibitor polyhydric phenols, substituted phenol, hydroquinone monomethyl ether, copper acetate, ferric chloride or quinones, but the health of the mankind is had impact by them, even toxic effect, can not be used in injection, therefore, houttuynine sodium bisulfite cannot solve in the pharmaceutical applications of the mankind；Simultaneously again owing to its bacteriostasis of Houttuyfonate homologues is far away from most antibiotic, oral medication dosage is big, takes effect slow, and doctor and patient seldom use；Herba Houttuyniae homologue R-CO-CH2-CHOH-SO3The defect of this auto polymerization of Na own, trend inevitable when injection is stopped using in human medicine, it is also inevitable for naturally withering away in oral medicine.
In in the past few decades, even if in field of veterinary, houttuynine sodium bisulfite and neo-houttuyninum also rarely have application, topmost reason one is that houttuynine sodium bisulfite class material itself is very unstable, two is whether decanoylacetaldehyde sodium hydrosulfite, or Sodium New Houttuyfonate, price is all sufficiently expensive, and people have more more excellent selection to give up the compound of this instability.Add catalogue and veterinary drug catalogue at China's pharmaceutical feed over the years, all never Sodium Houttuyfonate homologue is included in application category.Applying the injection pulvis that natural Herba Houttuyniae extract is made, started from 2007, owing to Herba Houttuyniae extract injection, the quality uncontrollability of pulvis itself and curative effect can not be stablized, many production licences are constantly revoked.
The natural Herba Houttuyniae collection of even handlebar among the people adds in feedstuff after drying, but to the Herba Houttuyniae after drying in a large number no matter how, all inspection does not measure decanoylacetaldehyde, and application has little effect, and for these reasons, this application provides a kind of feed additive.
Summary of the invention
Present invention solves the technical problem that and be in that to provide a kind of feed additive, the Houttuyfonate homologues that the application provides, as feed additive, has replacement feeding antibiotic, immunomodulating, pre-anti-virus and animal diarrhea and the pathogenetic function of disease.
In view of this, this application provides a kind of feed additive, including the such as Houttuyfonate homologues shown in formula I；
Wherein, R is C1～C25Alkyl or C1～C25Unsaturated alkyl.
Preferably, described feed additive also includes diluent, it is 100:(0.001～100000 that described diluent is selected from the mass ratio of one or more in stone powder, glucose, Semen Maydis powder, corn starch and wheat flour, described Houttuyfonate homologues and described diluent).
Preferably, also including antibiotic substance in described feed additive, described antibiotic substance is selected from one or more in cinnamic aldehyde, Oleum Bulbus Allii, eugenol, Herba Origani oil, thymol, O-p-Cymene-5-alcohol, carvacrol, glycerol monolaurate, enramycin, kitasamycin, oxytetracycline, chlortetracycline, bacitracin zinc, colistine sulfate, Salinomycin, avilamycin, nosiheptide, bambermycin, dimension element Buddhist nun Asia mycin, tylosin phosphonate, AI3-29795, lincomycin hydrochloride, Avilamycin and antibacterial peptide.
Preferably, described Houttuyfonate homologues is 100:(0.001～100000 with the mass ratio of described antibiotic substance).
Preferably, described in formula IIncluding such as formula (I1-1) shown in acetyl group, such as formula (I1-2) shown in propiono, such as formula (I1-3) shown in bytyry, such as formula (I1-4) shown in valeryl, such as formula (I1-5) shown in caproyl, such as formula (I1-6) shown in heptanoyl group, such as formula (I1-7) shown in caprylyl, such as formula (I1-8) shown in pelargonyl group, such as formula (I1-9) shown in capryl, such as formula (I1-10) shown in undecanoyl, such as formula (I1-11) shown in lauroyl, such as formula (I1-12) shown in tridecanoyl, such as formula (I1-13) shown in myristoyl, such as formula (I1-14) shown in pentadecanoyl, such as formula (I1-15) palmityl, such as formula (I1-16) shown in heptadecanoyl base, such as formula (I1-17) shown in stearyl, such as formula (I1-18) shown in 19 acyl groups, such as formula (I1-19) shown in 20 acyl groups, such as formula (I1-20) shown in two undecanoyl, such as formula (I1-21) shown in two dodecanoyls, such as formula (I1-22) shown in two tridecanoyl, such as formula (I1-23) shown in two myristoyl, such as formula (I1-24) shown in two pentadecanoyl, 2; 2-Dimethylpropanoyl, 2-ethyl hexyl acyl group, methylacryloyl, 2-ethyl-2,5-dimethyl caproyl, cinnamoyl, linolenyl, arachidonic acyl group, sub-oleoyl, eicosapentaenoic acyl group, two dodecahexaene acyl groups, conjugation Asia oleoyl or oleoyl；
Preferably, described formula (I1-8) described in one in the following formula of the isomers of pelargonyl group:
Preferably, described formula (I1-9) described in one in the following formula of the isomers of capryl:
Preferably, described Houttuyfonate homologues is selected from one or more in decanoylacetaldehyde sodium hydrosulfite, lauroyl syntheticum, new decanoylacetaldehyde sodium hydrosulfite and new nonanoyl syntheticum.
Present invention also provides a kind of feedstuff, including the feed additive described in such scheme and adjuvant.
Preferably, described feedstuff is the feedstuff of the feedstuff of pig, cattle, sheep, chicken, duck, goose, fish, shrimp, Eriocheir sinensis, Canis familiaris L., cat, ermine, deer, Testudinis or Monopteri albi and their different growth phases；The form of described feedstuff is selected from one or more in mixed feed, mixed fodder, concentrated feed, mineral trace element premixed feed, vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk and customization material；Described Houttuyfonate homologues content in feedstuff is 0.001～10000mg/kg.
The invention provides a kind of feed additive, it includes Houttuyfonate homologues, add the polymerization inhibitors such as the tert-butyl hydroquinone of feedstuff license, copper acetate, ferric chloride and can successfully solve its auto polymerization problem, make the feed additive of 50%, store 365 days, working substance retention ratio is still up to 98.3%, almost without loss, it is applied to feed manufacturing transporting procedures, finished feed retention rate is 97.9%, feed storage 60 days, retention rate still has 95.68%, fully meets requirements of the requirements of feed additive.The Houttuyfonate homologues that the application provides has replacement feeding antibiotic, immunomodulating, anti-bacteria and anti-virus and prevention animal diarrhea and the pathogenetic function of disease as feed additive.Be example with lauroyl acetaldehyde sulfurous hydracid sodium, new decanoylacetaldehyde sulfurous hydracid sodium, and caprinoyl acetyl sulfurous hydracid sodium, its disconnected piglet, broiler chicken, substitute antibiotics test in all obtain good effect.It addition, the application Houttuyfonate homologues as feed additive production cost than original technique save more than 95%, widely use in feedstuff for this product and provide probability.
Detailed description of the invention
In order to be further appreciated by the present invention, below in conjunction with embodiment, the preferred embodiment of the invention is described, but it is to be understood that these describe simply as further illustrating the features and advantages of the present invention, rather than limiting to the claimed invention.
The embodiment of the invention discloses a kind of feed additive, including the such as Houttuyfonate homologues shown in formula I；
Wherein, R is C1～C25Alkyl or C1～C25Unsaturated alkyl.
The feed additive Houttuyfonate homologues that the application provides, it has replacement feeding antibiotic, immunomodulating, pre-anti-virus and animal diarrhea and the pathogenetic function of disease.
Herein described Houttuyfonate homologues is prepared according to art methods, and this application is had no particular limits.R in herein described Houttuyfonate homologues is C1～C25Alkyl or C1～C25Unsaturated alkyl；Preferably, in described formula IIncluding such as formula (I1-1) shown in acetyl group, such as formula (I1-2) shown in propiono, such as formula (I1-3) shown in bytyry, such as formula (I1-4) shown in valeryl, such as formula (I1-5) shown in caproyl, such as formula (I1-6) shown in heptanoyl group, such as formula (I1-7) shown in caprylyl, such as formula (I1-8) shown in pelargonyl group, such as formula (I1-9) shown in capryl, such as formula (I1-10) shown in undecanoyl, such as formula (I1-11) shown in moon capryl, such as formula (I1-12) shown in tridecanoyl, such as formula (I1-13) shown in myristoyl, such as formula (I1-14) shown in pentadecanoyl, such as formula (I1-15) palmityl, such as formula (I1-16) shown in heptadecanoyl base, such as formula (I1-17) shown in stearyl, such as formula (I1-18) shown in 19 acyl groups, such as formula (I1-19) shown in 20 acyl groups, such as formula (I1-20) shown in two undecanoyl, such as formula (I1-21) shown in two dodecanoyls, such as formula (I1-22) shown in two tridecanoyl, such as formula (I1-23) shown in two myristoyl, such as formula (I1-24) shown in two pentadecanoyl, 2; 2-Dimethylpropanoyl, 2-ethyl hexyl acyl group, methylacryloyl, 2-ethyl-2,5-dimethyl caproyl, cinnamoyl, linolenyl, arachidonic acyl group, sub-oleoyl, eicosapentaenoic acyl group, two dodecahexaene acyl groups, conjugation Asia oleoyl or oleoyl；
Above-mentioned molecular formula (I1-1)～(I1-24) in every kind of molecular formula can include multiple different isomers respectively, described isomers is conventional group well known to those skilled in the art, and this application is had no particular limits.Example, described formula (I1-8) described in pelargonyl group include such as following formula (I1-8-1)～(I1-8-47) shown in isomers；Described formula (I1-9) described in capryl include such as following formula (I1-9-1)～(I1-9-106) shown in isomers, isomers the application of other molecular formula no longer repeats one by one, is isomers well known to those skilled in the art；
In an embodiment, described Houttuyfonate homologues is preferably one or more in decanoylacetaldehyde sulfurous hydracid sodium, lauroyl syntheticum, new decanoylacetaldehyde sulfurous hydracid sodium and new nonanoyl syntheticum.
Herein described feed additive also includes diluent, described diluent is diluent well known to those skilled in the art, preferably, described diluent is preferably selected from one or more in stone powder, glucose, Semen Maydis powder, corn starch, maltodextrin and wheat flour, and described diluent is preferably corn starch and maltodextrin；The mass ratio of described Houttuyfonate homologues and described diluent is 100:(0.001～100000), preferably, the mass ratio of described Houttuyfonate homologues and described diluent is preferably 100:(1～100000).
In order to make Houttuyfonate homologues have better antibacterial effect as feed additive, herein described feed additive also includes other antibiotic substance, described antibiotic substance is selected from cinnamic aldehyde, Oleum Bulbus Allii, eugenol, Herba Origani oil, o-p-Cymene-5-alcohol, carvacrol, thymol, glycerol monolaurate, enramycin, kitasamycin, oxytetracycline, chlortetracycline, bacitracin zinc, colistine sulfate, Salinomycin, avilamycin, nosiheptide, bambermycin, dimension element Buddhist nun Asia mycin, tylosin phosphonate, AI3-29795, lincomycin hydrochloride, one or more in Avilamycin and antibacterial peptide, in an embodiment, described antibiotic substance is preferably cinnamic aldehyde and carvacrol.The mass ratio of herein described Houttuyfonate homologues and described antibiotic substance is preferably 100:(0.001～100000), preferably, described Houttuyfonate homologues is preferably 100:(10～100000 with the mass ratio of described antibiotic substance).
Present invention also provides a kind of feedstuff, it includes the feed additive Houttuyfonate homologues described in such scheme and adjuvant.Described adjuvant is adjuvant well known to those skilled in the art, for instance one or more in stone powder, glucose, Semen Maydis powder, corn starch and maltodextrin.
Herein described feedstuff can know the feedstuff of animal as those skilled in the art, such as: herein described feedstuff can as the feedstuff of pig, cattle, sheep, chicken, duck, goose, fish, shrimp, Eriocheir sinensis, Canis familiaris L., cat, ermine, deer, Testudinis or Monopteri albi, it is also possible to as the feedstuff of above-mentioned animal different growth phases.
The form of herein described feedstuff is form well known to those skilled in the art, for instance: the form of described feedstuff is preferably selected from one or more in mixed feed, mixed fodder, concentrated feed, mineral trace element premixed feed, vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk and customization material.
Preferably, in herein described feedstuff, the content of Houttuyfonate homologues is preferably 0.001～10000mg/kg, more preferably 1～5000mg/kg, in an embodiment, more preferably 20～200mg/kg.
In order to be further appreciated by the present invention, below in conjunction with embodiment, feed additive provided by the invention being described in detail, protection scope of the present invention is not limited by the following examples.
Embodiment 1
Application corn starch, maltodextrin, antioxidant tertiary butyl hydroquinone (100mg/kg) and polymerization inhibitor copper acetate (500mg/kg) successively with lauroyl syntheticum, new decanoylacetaldehyde sodium hydrosulfite, new nonanoyl syntheticum, decanoylacetaldehyde sodium hydrosulfite make respectively containing 60% lauroyl syntheticum, 60% new decanoylacetaldehyde sodium hydrosulfite, 60% new nonanoyl syntheticum, 60% decanoylacetaldehyde sulfurous hydracid stable sodium feed additive.
Embodiment 2
Toasting 60 seconds under 60 DEG C in an oven, 70 DEG C, 80 DEG C, 90 DEG C, 100 DEG C states of four kinds of additive products embodiment 1 produced, detect the loss amount of above-mentioned four kinds of additives, testing result is as shown in table 1,
The loss amount tables of data of 1 four kinds of additives of table
As seen from the above table, having good stability of four kinds of feed additives, high-temperature baking loss is little not yet, and feed manufacturing process has granulation process, and temperature is 80-90 DEG C, about 10-30 time second, at once cooling, convulsion after granulation, and these four material is all salts substances, volatility almost without, thus, their stability meets the requirement of feed additive.
Embodiment 3
Four kinds of additives embodiment 1 produced add 300 grams/T in feedstuff, in finished product feedstuff, the material containing these four is 180 g ton, four kinds of feedstuffs are placed 90 days, respectively 15 days, 30 days, 45 days, 60 days, within 90 days, detect the content of various additive, and calculate the storage losses of corresponding time, result is as shown in table 2:
The storage losses tables of data of 2 four kinds of additives of table
Visible, through the storage of 90 days, four kinds of materials lose in feedstuff can be ignored.
Embodiment 4
Choose the close 21 age in days ablactational baby pig of size 60, it is divided into five groups, often three repetitions of group, each repetition four-head pig, male and female half and half, it is set to antibiotic matched group successively, matched group feedstuff per ton adds the kangdisu sulfas 200 grams of the Salinomycin 300 gram+10% of the 6-acetamido-1,2-dithiolo[4,3-b 300 gram+10% of 50% olaquindox 100 gram+25%, test group feedstuff per ton adds decanoylacetaldehyde sodium hydrosulfite 300 grams successively, new decanoylacetaldehyde sodium hydrosulfite 300 grams, new nonanoyl syntheticum 300 grams, test group is not added with any antibiotic, other feedstuff, uniform component causes, feeding and management condition is consistent, feed observation 30 days, its result is as shown in table 3:
Table 3 matched group and experimental group feed situation tables of data
Test shows, four kinds of Sodium Houttuyfonate sodium, is applied in swine rations, and pig feed intake, daily gain, feedstuff-meat ratio, diarrhea rate do not have significant difference, completely can substitute antibiotics.
Embodiment 5
Choose 28 age in days about 8kg wean three way cross piglets 100, close according to body weight.The principle of male and female half and half, is divided into 5 groups, often 4 repetitions of group, each repetition 5.Set comparison antibiotic group respectively, antibiotic group adds 10% kangdisu sulfas, 500 gram of+4% enramycin of 200 gram of+25% chlortetracycline 200 grams, test group adds decanoylacetaldehyde sodium hydrosulfite 15 grams+cinnamic aldehyde of 100 grams+carvacrol 50 grams respectively, new decanoylacetaldehyde sodium hydrosulfite 15 grams+cinnamic aldehyde of 100 grams+carvacrol 50 grams, lauroyl syntheticum 15 grams+cinnamic aldehyde of 100 grams+carvacrol 50 grams, new nonanoyl syntheticum 15 grams+cinnamic aldehyde of 100 grams+carvacrol 50 grams.
Table 4 basal diet composition and trophic level tables of data
| Raw material | Proportioning (%) | Nutritional labeling | Trophic level |
| Semen Maydis | 58.4 | Digestive enzyme (mg/kg) | 13.63 |
| Semen Glycines powder | 27.6 | Crude protein (%) | 19.95 |
| Imported fish meal | 5.2 | Calcium (%) | 0.8 |
| Milk extract powder | 3.8 | Available phosphorus | 0.4 |
| Oleum Glycines | 1.0 | Lysine | 1.15 |
| Additive premix | 4.0 | Methionine+cystine | 0.07 |
Note: the premix material of 4% is containing Cu, Fe, Mn, Zn, I, Se, VA, VD, VE, VK, VB1、VB6, folic acid, VB12, Vc, choline chloride, lysine, methionine, calcium formate, calcium hydrogen phosphate and Sal；
Feeding and management is consistent, feeds 30 days, and result is as shown in table 5:
Table 5 matched group and experimental group feed situation tables of data
More than test shows, four kinds of Herba Houttuyniae homologues are share in the feed for piglet with cinnamic aldehyde, carvacrol, obtain slightly good than antibiotic test effect, Houttuyfonate homologues R-CO-CH is described2-CHOH-SO3Na can replace antibiotic completely in suckling piglet daily ration, lower than antibiotic piglet diarrhea rate.
Embodiment 6
Choose 1 age in days Ai Wei bacterium broiler 150, it is divided into five groups, often 5 repetitions of group, 6 chickens of each repetition, male and female half and half, set matched group respectively as antibiotic group, adding the Salinomycin 500 grams of 50 gram of+10% kangdisu sulfas of 11% kitasamycin 100 gram+10%, test group adds decanoylacetaldehyde sodium hydrosulfite 50 grams, new decanoylacetaldehyde sodium hydrosulfite 50 grams respectively, lauroyl syntheticum 50 grams, new nonanoyl syntheticum 50 grams, other composition is consistent with basal diet, same feeding and management, feeding 28 days, result is as shown in table 6:
Table 6 matched group and experimental group feed situation tables of data
Result shows, four kinds of Sodium Houttuyfonate homologues are not notable with antibiotic group difference to test Broiler performance, completely can substitute antibiotics, its thymus, fabricius bursa weight ratio antibiotic group increase, IgA, IgB also significantly improve than antibiotic group, it was demonstrated that broiler chicken immunologic function is had adjustment effect by four kinds of Herba Houttuyniae homologues.IgM mainly plays pioneer's immunization infecting early stage, but the half-life is short, it is possible to it is low to infect the concentration regulating it successively, illustrates that infection occurrence frequency is low.
The explanation of above example is only intended to help to understand method and the core concept thereof of the present invention.It should be pointed out that, for those skilled in the art, under the premise without departing from the principles of the invention, it is also possible to the present invention carries out some improvement and modification, these improve and modify in the protection domain also falling into the claims in the present invention.
Described above to the disclosed embodiments, makes professional and technical personnel in the field be capable of or uses the present invention.The multiple amendment of these embodiments be will be apparent from for those skilled in the art, and generic principles defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention is not intended to be limited to the embodiments shown herein, and is to fit to the widest scope consistent with principles disclosed herein and features of novelty.
Claims (10)
1. a feed additive, including the such as Houttuyfonate homologues shown in formula I；
Wherein, R is C1～C25Alkyl or C1～C25Unsaturated alkyl.
2. feed additive according to claim 1, it is characterized in that, described feed additive also includes diluent, it is 100:(0.001～100000 that described diluent is selected from the mass ratio of one or more in stone powder, glucose, Semen Maydis powder, corn starch and wheat flour, described Houttuyfonate homologues and described diluent).
3. feed additive according to claim 1 and 2, it is characterized in that, described feed additive also includes antibiotic substance, described antibiotic substance is selected from cinnamic aldehyde, Oleum Bulbus Allii, eugenol, Herba Origani oil, thymol, O-p-Cymene-5-alcohol, carvacrol, glycerol monolaurate, enramycin, kitasamycin, oxytetracycline, chlortetracycline, bacitracin zinc, colistine sulfate, Salinomycin, avilamycin, nosiheptide, bambermycin, dimension element Buddhist nun Asia mycin, tylosin phosphonate, AI3-29795, lincomycin hydrochloride, one or more in Avilamycin and antibacterial peptide.
4. feed additive according to claim 3, it is characterised in that the mass ratio of described Houttuyfonate homologues and described antibiotic substance is 100:(0.001～100000).
5. feed additive according to claim 1, it is characterised in that described in formula IIncluding such as formula (I1-1) shown in acetyl group, such as formula (I1-2) shown in propiono, such as formula (I1-3) shown in bytyry, such as formula (I1-4) shown in valeryl, such as formula (I1-5) shown in caproyl, such as formula (I1-6) shown in heptanoyl group, such as formula (I1-7) shown in caprylyl, such as formula (I1-8) shown in pelargonyl group, such as formula (I1-9) shown in capryl, such as formula (I1-10) shown in undecanoyl, such as formula (I1-11) shown in lauroyl, such as formula (I1-12) shown in tridecanoyl, such as formula (I1-13) shown in myristoyl, such as formula (I1-14) shown in pentadecanoyl, such as formula (I1-15) palmityl, such as formula (I1-16) shown in heptadecanoyl base, such as formula (I1-17) shown in stearyl, such as formula (I1-18) shown in 19 acyl groups, such as formula (I1-19) shown in 20 acyl groups, such as formula (I1-20) shown in two undecanoyl, such as formula (I1-21) shown in two dodecanoyls, such as formula (I1-22) shown in two tridecanoyl, such as formula (I1-23) shown in two myristoyl, such as formula (I1-24) shown in two pentadecanoyl, 2; 2-Dimethylpropanoyl, 2-ethyl hexyl acyl group, methylacryloyl, 2-ethyl-2,5-dimethyl caproyl, cinnamoyl, linolenyl, arachidonic acyl group, sub-oleoyl, eicosapentaenoic acyl group, two dodecahexaene acyl groups, conjugation Asia oleoyl or oleoyl；
6. feed additive according to claim 5, it is characterised in that described formula (I1-8) described in one in the following formula of the isomers of pelargonyl group:
7. feed additive according to claim 5, it is characterised in that described formula (I1-9) described in one in the following formula of the isomers of capryl:
8. the feed additive according to any one of claim 1～7, it is characterized in that, described Houttuyfonate homologues is selected from one or more in decanoylacetaldehyde sodium hydrosulfite, lauroyl syntheticum, new decanoylacetaldehyde sodium hydrosulfite and new nonanoyl syntheticum.
9. a feedstuff, including the feed additive described in any one of claim 1～8 and adjuvant.
10. feedstuff according to claim 9, it is characterised in that described feedstuff is the feedstuff of the feedstuff of pig, cattle, sheep, chicken, duck, goose, fish, shrimp, Eriocheir sinensis, Canis familiaris L., cat, ermine, deer, Testudinis or Monopteri albi and their different growth phases；The form of described feedstuff is selected from one or more in mixed feed, mixed fodder, concentrated feed, mineral trace element premixed feed, vitamin premixed feed, compound premixed feed, expanded pellet diet, substitute breast milk and customization material；Described Houttuyfonate homologues content in feedstuff is 0.001～10000mg/kg.
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| CN106234771A (en) * | 2016-07-28 | 2016-12-21 | 湖南晶天科技实业有限公司 | A kind of feed additive, its application and a kind of feedstuff |
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