CN105749165A - Traditional Chinese medicine preparation containing folium artemisiae argyi for treating steatohepatitis with hyperlipidemia - Google Patents
Traditional Chinese medicine preparation containing folium artemisiae argyi for treating steatohepatitis with hyperlipidemia Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation containing folium artemisiae argyi for treating steatohepatitis with hyperlipidemia. The preparation is prepared from the following raw materials in parts by weight: 23-34 parts of folium artemisiae argyi, 22-32 parts of radix paeoniae rubra, 18-25 parts of rivier giantarum rhizome, 18-26 parts of silybum marianum, 18-25 parts of haws, 17-26 parts of rhizoma alismatis, 18-24 parts of zea mays, 13-19 parts of flos sophorae, 12-19 parts of rhizoma curcumae longae, 15-20 parts of angelica sinensis, 14-21 parts of dendrobium nobile and 6-15 parts of licorice roots. The traditional Chinese medicine composition has the characteristics of good effect, root cause and symptom treatment, small toxic and side effect and the like in the aspect of steatohepatitis with hyperlipidemia treatment. The preparation process is simple, convenient and feasible, and the preparation has stable medicinal effect and wide application range and is easy to popularize.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, particularly relate to a kind for the treatment of fat hepatitis containing tarragon and merge the Chinese medicine system of hyperlipemia
Agent.
Background technology
In recent years, along with raising and the change of dietary structure of people's living standard, fat hepatitis merges the incidence of disease of hyperlipemia day by day
Raise, have become as the common disease in daily life, frequently-occurring disease.Hyperlipemia is the pathologic basis that atherosclerotic is main, is also fat
One of cause of disease of fat liver.Epidemiological study shows, the hyperlipemia of 20%-92% merges fatty liver.Scholar's research is had to find China
Patients with Fatty Liver in mainly based on NASH.Patients with Fatty Liver there is a certain proportion of patient can develop into liver fibrosis
And cirrhosis, have a strong impact on quality of life.
Although doctor trained in Western medicine research in terms of the cause of disease and pathogenesis of fat hepatitis merging hyperlipemia is goed deep into, but not yet has in terms for the treatment of
Well way, mainly based on reducing blood lipid, incremental fat-reducing, control diabetes, liver protecting therapy, and has one with a lot of fat-reducing medicaments
Fixed hepatotoxicity wind agitation, also can make lipid accumulate in liver while promoting Liver Lipid Metabolism, and weight fat liver further.Still do not have at present
There is the specific medicament merging hyperlipemia treatment for fat hepatitis.And traditional Chinese medicine prevention fat hepatitis merges hyperlipemia good effect,
Side effect is little, the overall regulating body function of energy, has its characteristic and clear superiority.
Fat hepatitis merges hyperlipemia and belongs to the categories such as traditional Chinese medicine " phlegm is turbid ", " extravasated blood ", " hypochondriac pain ", " long-pending card ".Wherein
Cure the desease machine, the most duties in liver depression, insufficiency of the spleen, phlegm is turbid, blood stasis, treat with soothing the liver, invigorating the spleen, reduce phlegm, invigorate blood circulation as basic therapy.
In recent years, Chinese medicine compound prescription and Chinese patent drug are used for fat hepatitis and merge the intervention study of hyperlipemia by some scholars, and the therapy of application is most
For soothing liver and strengthening spleen, eliminate the phlegm and invigorate blood circulation, report in this respect be there is no for removing toxic substances therapy.It is many because of overfeeding cream that fat hepatitis merges hyperlipemia
Fine strain of millet delicious food savoury, disorder of emotion, inadequate natural endowment or old renal failure, poisoning such as are hindered at the disease, and its basic pathogenesis is asthenia in origin and asthenia in superficiality, the most also
It is not directed to three dirty-liver,spleen,kidneys.Its this void, the liver,spleen,kidney of duty, there is the genus that the deficiency of vital energy, the deficiency of Yin, the deficiency of yang, essence are lost；It marks real, has
Phlegm is turbid, and high, the stagnation of QI due to depression of the liver of sun, aleverzang-fire symptom-complex are not；If real the staying for a long time of mark is not gone, poor vein, extravasated blood is kept；The turbid knot of fighting with fire-evil of phlegm,
The turbid poison of variable life, or heat poison, be also important mark real example.
Summary of the invention
It is an object of the invention to overcome weak point of the prior art, it is provided that a kind for the treatment of fat hepatitis containing tarragon merges high fat of blood
The Chinese medicine preparation of disease, described Chinese medicine preparation has soothing liver-gallbladder, the effect of blood fat of invigorating the spleen and benefiting qi, reduce, and can overcome simultaneously and control at present
It is poor to there is result for the treatment of in the medicine for the treatment of fat hepatitis merging hyperlipemia, the defect that side effect is many.
For realizing the purpose of the present invention, technical solution of the present invention is as follows:
Chinese medicine preparation of the present invention is made up of the raw material of following parts by weight:
Tarragon 23-34 part, radix paeoniae rubrathe 22-32 part, konjaku 18-25 part, milk thistle 18-26 part, hawthorn 18-25 part, rhizoma alismatis 17-26 part,
Popcorn 18-24 part, sophora flower 13-19 part, turmeric 12-19 part, Radix Angelicae Sinensis 15-20 part, stem of noble dendrobium 14-21 part and Radix Glycyrrhizae 6-15 part.
Preferably, the described treatment fat hepatitis containing tarragon merges the Chinese medicine preparation of hyperlipemia by the raw material group of following parts by weight
Become:
Tarragon 23 parts, the radix paeoniae rubrathe 22 parts, konjaku 18 parts, milk thistle 18 parts, hawthorn 18 parts, rhizoma alismatis 17 parts, popcorn 18 parts, Chinese scholartree
Spend 13 parts, 12 parts of turmeric, Radix Angelicae Sinensis 15 parts, the stem of noble dendrobium 14 parts and 6 parts of Radix Glycyrrhizae.
Preferably, the described treatment fat hepatitis containing tarragon merges the Chinese medicine preparation of hyperlipemia by the raw material group of following parts by weight
Become:
Tarragon 34 parts, the radix paeoniae rubrathe 32 parts, konjaku 25 parts, milk thistle 26 parts, hawthorn 25 parts, rhizoma alismatis 26 parts, popcorn 24 parts, Chinese scholartree
Spend 19 parts, 19 parts of turmeric, Radix Angelicae Sinensis 20 parts, the stem of noble dendrobium 21 parts and 15 parts of Radix Glycyrrhizae.
Preferably, the described treatment fat hepatitis containing tarragon merges the Chinese medicine preparation of hyperlipemia by the raw material group of following parts by weight
Become:
Tarragon 28 parts, the radix paeoniae rubrathe 27 parts, konjaku 22 parts, milk thistle 22 parts, hawthorn 21 parts, rhizoma alismatis 21 parts, popcorn 22 parts, Chinese scholartree
Spend 16 parts, 15 parts of turmeric, Radix Angelicae Sinensis 17 parts, the stem of noble dendrobium 18 parts and 10 parts of Radix Glycyrrhizae.
Further, it is granule, tablet, capsule that the described treatment fat hepatitis containing tarragon merges the Chinese medicine preparation of hyperlipemia
Agent, gel, cream or powder.
Additionally, the present invention also provides for the preparation method of described Chinese medicine preparation, it comprises the steps of
S1: weigh respectively tarragon, the radix paeoniae rubrathe, konjaku, milk thistle, hawthorn, rhizoma alismatis, popcorn, sophora flower, turmeric, Radix Angelicae Sinensis, the stem of noble dendrobium,
Radix Glycyrrhizae, dry, pulverize, and obtains medicinal material coarse powder；
S2: the ingredients meal prepared by S1 merges, and adds total medicinal material 5-8 times amount water soaking 1-2 hour, decocts 1-3 hour；
Filtering, filter residue adds total medicinal material 2-5 times amount water, decocts 1-2 hour；Filtering, merge twice filtrate, filtrate is concentrated at 50 DEG C-60 DEG C
Relative density is the thick paste of 1.20-1.30, drying under reduced pressure, crosses 100-200 mesh sieve, obtains fine medicinal material powder；
S3: add auxiliary material in the fine medicinal material powder that S2 prepares, make the Chinese medicine preparation of finished product.
Ingredients nature and flavor in Chinese medicine preparation prescription of the present invention, return through and effect:
Tarragon: this product is the dry leaf of feverfew Chinese mugwort；Taste is pungent, bitter, warm in nature；Return spleen, liver, kidney channel；Warming channel for arresting bleeding, dissipates cold stopping
Bitterly.
The radix paeoniae rubrathe: this product is ranunculaceae plant Chinese herbaceous peony or the river radix paeoniae rubrathe is dried root；Bitter, cold nature；Return Liver Channel；Clearing heat and cooling blood, only dissipates the stasis of blood
Bitterly.
Konjaku: this product is Araeceae Amorphophallus plant konjaku, is used as medicine with spherical tuber；Taste is pungent, cold in nature；The thoughts of returning home, Liver Channel；Detumescence
Dissipating bind, pain relieving of detoxifying, reducing phlegm, it is long-pending to disappear.
Milk thistle: this product is composite family Silybum plant milk thistle, is used as medicine with achene；Bitter；Cool in nature；Clearing heat and promoting diuresis, soothing liver-gallbladder.
Hawthorn: this product is the dry mature fruit of rosaceous plant large-fruited Chinese hawthorn；Taste is sour, sweet, slightly warm in nature；Return spleen, stomach, Liver Channel；Disappear
Food stomach invigorating, promoting the circulation of qi dissipates the stasis of blood.
Rhizoma alismatis: this product is Notes On Alism At Aceae rhizoma alismatis. dry tuber；Taste is sweet, cold in nature；Return kidney, bladder warp；Diuresis, clearing away damp-heat.
Popcorn: this product is grass zeistic male flower fringe；Taste is sweet；Cool in nature；Return Liver Channel；Soothing liver-gallbladder.
Sophora flower: this product is the dry flower and alabastrum of legume Chinese scholartree；Bitter, cold nature；Return liver, large intestine channel；Cooling blood and hemostasis, clearing liver
Purging intense heat.
Turmeric: this product is the dry rhizome of zingiberaceous plant turmeric；Taste is pungent, bitter, warm in nature；Return spleen, Liver Channel；Broken blood gas, only stimulates the menstrual flow
Bitterly.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica；Taste is sweet, pungent, warm in nature；Return liver, the heart, the spleen channel；Replenishing and activating blood, adjusts
Meridian and relieving pain, relaxes bowel.
The stem of noble dendrobium: this product is orchid dendrobium loddigesii Rolfe, stem of Eyeshaped Dendrobium, HERBA DENDROBII., dendrobium candidum or HERBA DENDROBII fresh or dry
Stem；Taste is sweet, cold nature；Return stomach, kidney channel；Reinforcing stomach reg fluid is nourishing Yin and clearing heat.
Radix Glycyrrhizae: this product is glycyrrhizic legume, swollen fruit Radix Glycyrrhizae or the dry root of glycyrrhiza glabra.Taste is sweet, and property is put down；The thoughts of returning home, lung, spleen,
Stomach warp；Invigorate the spleen and benefit qi, clearing heat and detoxicating, coordinating the drug actions of a prescription.
The prescription analysis of Chinese medicine preparation of the present invention:
Chinese medicine preparation of the present invention is with tarragon, the radix paeoniae rubrathe as monarch drug in a prescription, warming channel for arresting bleeding, eliminating cold to stop pain, clearing heat and cooling blood；With konjaku, milk thistle,
Hawthorn, rhizoma alismatis are ministerial drug, dispersing swelling and dissipating binds, and pain relieving of detoxifying, reducing phlegm, it is long-pending to disappear, clearing heat and promoting diuresis, soothing liver-gallbladder；With popcorn, sophora flower, ginger
Huang, Radix Angelicae Sinensis, the stem of noble dendrobium are adjutant, mental-tranquilization, pus draining and toxin expelling；With Radix Glycyrrhizae for making medicine, the coordinating the drug actions of a prescription property of medicine, all medicines coordinate, Xiang Fuxiang
Become, synergy, play soothing liver-gallbladder altogether, invigorate the spleen and benefit qi, reduce the effect such as blood fat, reinforcing stomach reg fluid, fat hepatitis is merged high fat of blood
Disease has significant curative effect.
Compared with prior art, beneficial effects of the present invention is summarized as follows:
The prescription of the Chinese medicine preparation that the present invention provides is the traditional Chinese medicine ingredients of pure natural, has no adverse reaction, and toxic and side effect is low；Animal experiment
Result shows, Chinese medicine preparation of the present invention can significantly reduce fat hepatitis merge the triglycerides in hyperlipemia rat blood serum, T-CHOL,
The content of the MDA in glutamic-oxalacetic transaminease, glutamic-pyruvic transaminase and liver, increases containing of the superoxide dismutase in liver and glutathione
Amount, has significant anti peroxidation of lipid and effect for reducing blood fat, and liver is had protective effect, and fat hepatitis is merged hyperlipemia
There is more significant curative effect.Additionally, the synergy of ingredients is strong in Chinese medicine preparation prescription of the present invention, taking dose is little, simultaneously will not
Produce drug dependence.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example.Within the scope of the invention or
Person without departing from present disclosure, spirit and scope, the change that carries out the present invention, combines or replaces, for the technology of this area
It is apparent from for personnel, and is included within the scope of the present invention.
Embodiment 1
The Chinese medicine preparation of the embodiment of the present invention 1 is made up of the raw material of following parts by weight:
Tarragon 23 parts, the radix paeoniae rubrathe 22 parts, konjaku 18 parts, milk thistle 18 parts, hawthorn 18 parts, rhizoma alismatis 17 parts, popcorn 18 parts, Chinese scholartree
Spend 13 parts, 12 parts of turmeric, Radix Angelicae Sinensis 15 parts, the stem of noble dendrobium 14 parts and 6 parts of Radix Glycyrrhizae.
Preparation method:
S1: weigh tarragon, the radix paeoniae rubrathe, konjaku, milk thistle, hawthorn, rhizoma alismatis, popcorn, sophora flower, turmeric, Radix Angelicae Sinensis, the stem of noble dendrobium, Radix Glycyrrhizae,
Dry, pulverize, obtain medicinal material coarse powder；
S2: the fine powder prepared by S1, adds total medicinal material 5 times amount water soaking 1 hour, decocts 1 hour；Filtering, filter residue adds total medicine
Material 2 times amount water, decocts 1 hour；Filtering, merge twice filtrate, it is the thick paste of 1.20 that filtrate is concentrated into relative density at 50 DEG C, decompression
It is dried, crosses 100 mesh sieves, obtain fine medicinal material powder；
S3: add auxiliary material in the fine medicinal material powder that S2 prepares, make capsule.
Embodiment 2
The Chinese medicine preparation of the embodiment of the present invention 2 is made up of the raw material of following parts by weight:
Tarragon 34 parts, the radix paeoniae rubrathe 32 parts, konjaku 25 parts, milk thistle 26 parts, hawthorn 25 parts, rhizoma alismatis 26 parts, popcorn 24 parts, Chinese scholartree
Spend 19 parts, 19 parts of turmeric, Radix Angelicae Sinensis 20 parts, the stem of noble dendrobium 21 parts and 15 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3
The Chinese medicine preparation of the embodiment of the present invention 3 is made up of the raw material of following parts by weight:
Tarragon 28 parts, the radix paeoniae rubrathe 27 parts, konjaku 22 parts, milk thistle 22 parts, hawthorn 21 parts, rhizoma alismatis 21 parts, popcorn 22 parts, Chinese scholartree
Spend 16 parts, 15 parts of turmeric, Radix Angelicae Sinensis 17 parts, the stem of noble dendrobium 18 parts and 10 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Chinese medicine preparation pharmacodynamic study of the present invention:
Chinese medicine preparation of the present invention merges hyperlipemia rat effect to fat hepatitis.
1. experimental animal: SD rat (in Zhongshan University animal used as test provide) 72, body weight 350 ± 20g, male and female half and half, female greatly
Mouse is all without pregnant.
2. test method: 72 SD rats are randomly divided into 6 groups, respectively normal group, model group, positive controls, test A,
B, C group, often group 12.In addition to normal group, remaining each group gives fat emulsion gavage (10ml kg-1) while feeding normal diet,
Normal group is feeding the isopyknic purified water of gavage while normal diet, every day gavage 1 time, continuous gavage 4 weeks, stop fatty after 4 weeks
Emulsion gavage, each group rat starts to be administered, and administering mode is: positive controls gavage to blood fat recovery capsule (traditional Chinese medicines quasi-word H44024853,
Beijing WBL Peking University Biotech Co., Ltd), dosage is 60mg/kg/d；Test A, B, the other gavage of component C are real to the present invention
Executing the solution that the prepared capsule of example 1-3 is made, dosage is 50mg/kg/d；Normal group and model group gavage give isopyknic physiology salt
Water, each group gavage every day 2 times, continuous gavage 4 weeks, put to death rat after off-test, take serum and liver, measure respectively in serum
MDA (MDA) in triglycerides (TG), T-CHOL (TC), glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST) content and liver,
Superoxide dismutase (SOD) and the content of glutathione (GSH), and liver is carried out pathologic finding.
3. experimental result:
The comparision contents of TG, TC, ALT and AST in rat blood serum respectively organized by table 1
| Group | TG/mmol·L-1 | TC/mmol·L-1 | ALT/U·L-1 | AST/U·L-1 |
| Normal group | 0.48±0.08 | 1.40±0.16 | 26.62±8.56 | 24.25±8.12 |
| Model group | 0.86±0.13## | 2.65±0.37## | 43.40±13.37# | 40.55±12.30# |
| Positive controls | 0.67±0.08* | 1.77±0.23* | 28.75±9.42* | 27.25±7.02* |
| Test A group | 0.56±0.07** | 1.45±0.15** | 27.83±8.80* | 26.03±7.36* |
| Test B group | 0.55±0.05** | 1.43±0.18** | 27.25±8.13* | 25.52±7.70* |
| Test C group | 0.50±0.09**△ | 1.40±0.19** | 26.80±9.25* | 24.20±8.32* |
Note: compare with normal group,#P ＜ 0.05,##P ＜ 0.01；Compare with model group,*P ＜ 0.05,**P ＜ 0.01；Compare with positive controls,△P ＜ 0.05.
The comparision contents of MDA, SOD and GSH in rat liver respectively organized by table 2
| Group | MDA/nmol·mL-1 | SOD/NU·mL-1 | GSH/mg·L-1 |
| Normal group | 7.72±1.08 | 455.30±80.25 | 51.24±10.12 |
| Model group | 15.02±2.60## | 277.72±31.08## | 26.12±6.25## |
| Positive controls | 9.80±1.22* | 381.45±60.12* | 38.45±6.15* |
| Test A group | 7.58±1.00** | 400.45±58.67* | 47.65±7.61** |
| Test B group | 7.63±1.07** | 412.30±57.23* | 45.89±8.03** |
| Test C group | 7.50±1.10** | 415.30±58.05* | 50.89±7.13**△ |
Note: compare with normal group,##P ＜ 0.01；Compare with model group,*P ＜ 0.05,**P ＜ 0.01；Compare with positive controls,△P ＜ 0.05.
From Tables 1 and 2, the Chinese medicine preparation that the embodiment of the present invention 1,2,3 prepares all can significantly reduce fat hepatitis and merge high blood
TG, TC, ALT and AST content in fat disease rat blood serum, significantly reduces liver MDA content simultaneously, increases liver SOD and GSH
Content, its effect is more notable than the effect of positive drug blood fat recovery capsule, and wherein test C group reduces TG content and increase liver in serum
The effect of the content of GSH and the effectiveness comparison of blood fat recovery capsule, have significant difference, and result above shows that Chinese medicine preparation of the present invention has
Significantly anti peroxidation of lipid and effect for reducing blood fat, and liver is had protective effect, therefore, Chinese medicine preparation of the present invention is for fatty liver
The scorching hyperlipemia that merges has more significant curative effect, is suitably applied treatment fat hepatitis and merges hyperlipemia.
Below it is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as limitation of the present invention,
Protection scope of the present invention should be as the criterion with claim limited range.For those skilled in the art, not
Depart from the spirit and scope of the present invention, it is also possible to making some improvements and modifications, these improvements and modifications also should be regarded as the protection of the present invention
Scope.
Claims (6)
1. one kind containing tarragon treatment fat hepatitis merge hyperlipemia Chinese medicine preparation, it is characterised in that described Chinese medicine preparation by
The raw material composition of following parts by weight:
Tarragon 23-34 part, radix paeoniae rubrathe 22-32 part, konjaku 18-25 part, milk thistle 18-26 part, hawthorn 18-25 part, rhizoma alismatis 17-26 part,
Popcorn 18-24 part, sophora flower 13-19 part, turmeric 12-19 part, Radix Angelicae Sinensis 15-20 part, stem of noble dendrobium 14-21 part and Radix Glycyrrhizae 6-15 part.
Treatment fat hepatitis the most according to claim 1 merges the Chinese medicine preparation of hyperlipemia, it is characterised in that described Chinese medicine
Preparation is made up of the raw material of following parts by weight:
Tarragon 23 parts, the radix paeoniae rubrathe 22 parts, konjaku 18 parts, milk thistle 18 parts, hawthorn 18 parts, rhizoma alismatis 17 parts, popcorn 18 parts,
13 parts of sophora flower, 12 parts of turmeric, Radix Angelicae Sinensis 15 parts, the stem of noble dendrobium 14 parts and 6 parts of Radix Glycyrrhizae.
Treatment fat hepatitis the most according to claim 1 merges the Chinese medicine preparation of hyperlipemia, it is characterised in that described Chinese medicine
Preparation is made up of the raw material of following parts by weight:
Tarragon 34 parts, the radix paeoniae rubrathe 32 parts, konjaku 25 parts, milk thistle 26 parts, hawthorn 25 parts, rhizoma alismatis 26 parts, popcorn 24 parts,
19 parts of sophora flower, 19 parts of turmeric, Radix Angelicae Sinensis 20 parts, the stem of noble dendrobium 21 parts and 15 parts of Radix Glycyrrhizae.
Treatment fat hepatitis the most according to claim 1 merges the Chinese medicine preparation of hyperlipemia, it is characterised in that described Chinese medicine
Preparation is made up of the raw material of following parts by weight:
Tarragon 28 parts, the radix paeoniae rubrathe 27 parts, konjaku 22 parts, milk thistle 22 parts, hawthorn 21 parts, rhizoma alismatis 21 parts, popcorn 22 parts,
16 parts of sophora flower, 15 parts of turmeric, Radix Angelicae Sinensis 17 parts, the stem of noble dendrobium 18 parts and 10 parts of Radix Glycyrrhizae.
5. merge the Chinese medicine preparation of hyperlipemia according to the arbitrary described treatment fat hepatitis of claim 1-4, it is characterised in that described
Chinese medicine preparation is granule, tablet, capsule, gel, cream or powder.
6. merge the Chinese medicine preparation of hyperlipemia according to the arbitrary described treatment fat hepatitis of claim 1-4, it is characterised in that described
The preparation method of Chinese medicine preparation comprises the steps of
S1: weigh respectively tarragon, the radix paeoniae rubrathe, konjaku, milk thistle, hawthorn, rhizoma alismatis, popcorn, sophora flower, turmeric, Radix Angelicae Sinensis, the stem of noble dendrobium,
Radix Glycyrrhizae, dry, pulverize, and obtains medicinal material coarse powder；
S2: the ingredients meal prepared by S1 merges, and adds total medicinal material 5-8 times amount water soaking 1-2 hour, decocts 1-3 hour；
Filtering, filter residue adds total medicinal material 2-5 times amount water, decocts 1-2 hour；Filtering, merge twice filtrate, filtrate is concentrated at 50 DEG C-60 DEG C
Relative density is the thick paste of 1.20-1.30, drying under reduced pressure, crosses 100-200 mesh sieve, obtains fine medicinal material powder；
S3: add auxiliary material in the fine medicinal material powder that S2 prepares, make the Chinese medicine preparation of finished product.
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