CN105748736A - 一种治疗慢性鼻窦炎的中药组合物及其制备方法和用途 - Google Patents
一种治疗慢性鼻窦炎的中药组合物及其制备方法和用途 Download PDFInfo
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Abstract
本发明公开了一种治疗慢性鼻窦炎的中药组合物,由以下按照重量份的原料组成:桔梗1216份、柴胡710份、辛夷花1519份、苍耳子811份、连翘1216份、路路通1013份、败酱草2025份、蒲公英35份、熟地710份、金银花1620份、刺蒺藜58份、川芎46份、蔓荆子58份、细辛59份、薄荷79份、甘草811份、白头翁1014份、豨莶草912份。本发明还提供了所述治疗慢性鼻窦炎的中药组合物的制备方法。本发明制备的中药组合物对鼻窦炎疗效显著,无耐药性及毒副作用,能够彻底治愈鼻窦炎,容易被患者接受,且成本较低。
Description
技术领域
本发明涉及中药领域,具体是一种治疗慢性鼻窦炎的中药组合物及其制备方法和用途。
背景技术
慢性鼻窦炎是临床常见病、多发病,主要表现为鼻塞、流涕、头晕、头闷痛、嗅觉减退、注意力不集中、记忆力下降等症状,严重影响患者学习、生活。慢性鼻窦炎的发病是多种致病因素共同作用的结果,包括局部致病菌感染、机体变态反应性增高、微循环障碍口鼻道复合体畸形及全身免疫力低下等,导致鼻粘膜水肿、增厚及息肉样变、囊性改变,或纤维组织增生、血管阻塞,腺体萎缩,粘膜萎缩。
西医主要为对症治疗如:局部滴药(常用血管收缩剂滴鼻和皮质类固醇激素,改善鼻腔通气)和引流;在正规的保守治疗无效后方可采用鼻腔病变手术以解除中鼻道及其附近区域的阻塞,改善鼻窦引流和通气,促进鼻窦炎症的消退,如中鼻甲、下鼻甲部分切除术和鼻中隔偏曲矫正术等。西医治疗本病虽有一定疗效,但存在易复发,西药副作用较大,手术治疗患者往往不易接受等问题。
中医学将本病归属“鼻渊”、“脑漏”等范畴。中医学认为该病是外邪湿热,由表入里,经过肝胆上移于脑,或风湿伏郁,活肺肾虚弱,影响全身发热头痛,其湿热流窜于鼻腔内,引发了鼻腔内的系列病变。虽表现于鼻,实则反应腑脏,反应经络的病变。中医以健脾益肺,温肾通窍,活血排脓为治则。常见症状为,鼻流浊涕而量多,常伴有头痛,鼻塞,嗅觉减退,鼻内粘膜红赤或淡红肿胀,在两眉间或颧部有压痛等。
市场上有很多治疗慢性鼻窦炎的中成药,但这些中成药疗效参差不齐,且普遍存在药效差、起效慢等缺陷,市场上需求一种安全有效、疗效显著的治疗鼻窦炎的中药制剂。
发明内容
本发明的目的在于提供一种治疗慢性鼻窦炎的中药组合物及其制备方法和用途,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
一种治疗慢性鼻窦炎的中药组合物,由以下按照重量份的原料组成:桔梗12-16份、柴胡7-10份、辛夷花15-19份、苍耳子8-11份、连翘12-16份、路路通10-13份、败酱草20-25份、蒲公英3-5份、熟地7-10份、金银花16-20份、刺蒺藜5-8份、川芎4-6份、蔓荆子5-8份、细辛5-9份、薄荷7-9份、甘草8-11份、白头翁10-14份、豨莶草9-12份。
作为本发明进一步的方案:由以下按照重量份的原料组成:桔梗13-14份、柴胡8-9份、辛夷花16-18份、苍耳子9-10份、连翘13-15份、路路通11-12份、败酱草21-24份、蒲公英4-5份、熟地8-9份、金银花17-19份、刺蒺藜6-7份、川芎4-5份、蔓荆子6-7份、细辛6-8份、薄荷7-8份、甘草9-10份、白头翁11-13份、豨莶草10-11份。
作为本发明再进一步的方案:由以下按照重量份的原料组成:桔梗14份、柴胡8份、辛夷花17份、苍耳子9份、连翘14份、路路通12份、败酱草23份、蒲公英4份、熟地9份、金银花18份、刺蒺藜7份、川芎5份、蔓荆子6份、细辛7份、薄荷8份、甘草10份、白头翁12份、豨莶草11份。
所述治疗慢性鼻窦炎的中药组合物的制备方法,步骤如下:
1)称取桔梗、柴胡、辛夷花、蔓荆子、细辛、薄荷、甘草、白头翁,加入12-15倍量的食用酒精,浸泡1-2h后,加热回流提取1-2h,过滤,获得第一提取液,将滤渣再次加入6-8倍量的食用酒精,浸泡0.5-1h后,加热回流提取0.5-1h,过滤,获得第二提取液,将第一提取液与第二提取液合并,获得提取总液,备用;
2)称取豨签草,加入8-10倍量的食用酒精,浸泡2-3h后,超声波提取55-60min,获得超声波提取液,备用;
3)称取苍耳子、连翘、路路通、败酱草、蒲公英、熟地、金银花、刺蒺藜、川芎,加入10-12倍量的水,浸泡1-2h后,煮沸1-2h,分离一次煎煮液,将药渣再次加入6-8倍量的水,浸泡1-2h后,煮沸0.5-1h,分离二次煎煮液,将一次煎煮液和二次煎煮液合并,过滤,获得煎煮总液;
4)将提取总液、超声波提取液和煎煮总液合并,混合均匀,并在蒸发器中蒸发浓缩为稠膏;
5)将稠膏烘干后粉碎,过150-200目筛,将获得的细末加入适量淀粉及糊精,制成片剂或胶囊。
上述中药组合物能够用于治疗慢性鼻窦炎。
与现有技术相比,本发明的有益效果是:
本发明制备的中药组合物对鼻窦炎疗效显著,与西药相比,其无耐药性及毒副作用,且能够彻底治愈鼻窦炎,治愈后不易复发。与手术治疗相比,更容易被患者接受,且成本较低。
具体实施方式
下面结合具体实施方式对本发明的技术方案作进一步详细地说明。
实施例1
一种治疗慢性鼻窦炎的中药组合物,由以下按照重量份的原料组成:桔梗12份、柴胡7份、辛夷花15份、苍耳子8份、连翘12份、路路通10份、败酱草20份、蒲公英3份、熟地7份、金银花16份、刺蒺藜5份、川芎4份、蔓荆子5份、细辛5份、薄荷7份、甘草8份、白头翁10份、豨莶草9份。
所述治疗慢性鼻窦炎的中药组合物的制备方法,步骤如下:
1)称取桔梗、柴胡、辛夷花、蔓荆子、细辛、薄荷、甘草、白头翁,加入12倍量的食用酒精,浸泡1h后,加热回流提取1h,过滤,获得第一提取液,将滤渣再次加入6倍量的食用酒精,浸泡0.5h后,加热回流提取0.5h,过滤,获得第二提取液,将第一提取液与第二提取液合并,获得提取总液,备用;
2)称取豨签草,加入8倍量的食用酒精,浸泡2h后,超声波提取55min,获得超声波提取液,备用;
3)称取苍耳子、连翘、路路通、败酱草、蒲公英、熟地、金银花、刺蒺藜、川芎,加入10倍量的水,浸泡1h后,煮沸1h,分离一次煎煮液,将药渣再次加入6倍量的水,浸泡1h后,煮沸0.5h,分离二次煎煮液,将一次煎煮液和二次煎煮液合并,过滤,获得煎煮总液;
4)将提取总液、超声波提取液和煎煮总液合并,混合均匀,并在蒸发器中蒸发浓缩为稠膏;
5)将稠膏烘干后粉碎,过150目筛,将获得的细末加入适量淀粉及糊精,制成片剂。
实施例2
一种治疗慢性鼻窦炎的中药组合物,由以下按照重量份的原料组成:桔梗13份、柴胡10份、辛夷花16份、苍耳子8份、连翘15份、路路通11份、败酱草20份、蒲公英5份、熟地8份、金银花16份、刺蒺藜8份、川芎5份、蔓荆子8份、细辛7份、薄荷7份、甘草11份、白头翁12份、豨莶草10份。
所述治疗慢性鼻窦炎的中药组合物的制备方法,步骤如下:
1)称取桔梗、柴胡、辛夷花、蔓荆子、细辛、薄荷、甘草、白头翁,加入14倍量的食用酒精,浸泡2h后,加热回流提取1.5h,过滤,获得第一提取液,将滤渣再次加入6倍量的食用酒精,浸泡0.5h后,加热回流提取0.5h,过滤,获得第二提取液,将第一提取液与第二提取液合并,获得提取总液,备用;
2)称取豨签草,加入9倍量的食用酒精,浸泡3h后,超声波提取56min,获得超声波提取液,备用;
3)称取苍耳子、连翘、路路通、败酱草、蒲公英、熟地、金银花、刺蒺藜、川芎,加入11倍量的水,浸泡1.5h后,煮沸1.5h,分离一次煎煮液,将药渣再次加入8倍量的水,浸泡2h后,煮沸1h,分离二次煎煮液,将一次煎煮液和二次煎煮液合并,过滤,获得煎煮总液;
4)将提取总液、超声波提取液和煎煮总液合并,混合均匀,并在蒸发器中蒸发浓缩为稠膏;
5)将稠膏烘干后粉碎,过200目筛,将获得的细末加入适量淀粉及糊精,制成胶囊。
实施例3
一种治疗慢性鼻窦炎的中药组合物,由以下按照重量份的原料组成:桔梗14份、柴胡8份、辛夷花17份、苍耳子9份、连翘14份、路路通12份、败酱草23份、蒲公英4份、熟地9份、金银花18份、刺蒺藜7份、川芎5份、蔓荆子6份、细辛7份、薄荷8份、甘草10份、白头翁12份、豨莶草11份。
所述治疗慢性鼻窦炎的中药组合物的制备方法,步骤如下:
1)称取桔梗、柴胡、辛夷花、蔓荆子、细辛、薄荷、甘草、白头翁,加入14倍量的食用酒精,浸泡1.5h后,加热回流提取1.5h,过滤,获得第一提取液,将滤渣再次加入7倍量的食用酒精,浸泡1h后,加热回流提取1h,过滤,获得第二提取液,将第一提取液与第二提取液合并,获得提取总液,备用;
2)称取豨签草,加入9倍量的食用酒精,浸泡2.5h后,超声波提取58min,获得超声波提取液,备用;
3)称取苍耳子、连翘、路路通、败酱草、蒲公英、熟地、金银花、刺蒺藜、川芎,加入11倍量的水,浸泡1.5h后,煮沸1.5h,分离一次煎煮液,将药渣再次加入7倍量的水,浸泡1.5h后,煮沸1h,分离二次煎煮液,将一次煎煮液和二次煎煮液合并,过滤,获得煎煮总液;
4)将提取总液、超声波提取液和煎煮总液合并,混合均匀,并在蒸发器中蒸发浓缩为稠膏;
5)将稠膏烘干后粉碎,过180目筛,将获得的细末加入适量淀粉及糊精,制成胶囊。
实施例4
一种治疗慢性鼻窦炎的中药组合物,由以下按照重量份的原料组成:桔梗15份、柴胡7份、辛夷花15份、苍耳子11份、连翘14份、路路通12份、败酱草23份、蒲公英5份、熟地8份、金银花20份、刺蒺藜6份、川芎4份、蔓荆子7份、细辛8份、薄荷7份、甘草8份、白头翁11份、豨莶草10份。
所述治疗慢性鼻窦炎的中药组合物的制备方法,步骤如下:
1)称取桔梗、柴胡、辛夷花、蔓荆子、细辛、薄荷、甘草、白头翁,加入13倍量的食用酒精,浸泡1.5h后,加热回流提取1h,过滤,获得第一提取液,将滤渣再次加入8倍量的食用酒精,浸泡0.5h后,加热回流提取0.5h,过滤,获得第二提取液,将第一提取液与第二提取液合并,获得提取总液,备用;
2)称取豨签草,加入9倍量的食用酒精,浸泡3h后,超声波提取55min,获得超声波提取液,备用;
3)称取苍耳子、连翘、路路通、败酱草、蒲公英、熟地、金银花、刺蒺藜、川芎,加入11倍量的水,浸泡2h后,煮沸1h,分离一次煎煮液,将药渣再次加入6倍量的水,浸泡2h后,煮沸0.5h,分离二次煎煮液,将一次煎煮液和二次煎煮液合并,过滤,获得煎煮总液;
4)将提取总液、超声波提取液和煎煮总液合并,混合均匀,并在蒸发器中蒸发浓缩为稠膏;
5)将稠膏烘干后粉碎,过160目筛,将获得的细末加入适量淀粉及糊精,制成片剂。
实施例5
一种治疗慢性鼻窦炎的中药组合物,由以下按照重量份的原料组成:桔梗16份、柴胡10份、辛夷花19份、苍耳子11份、连翘16份、路路通13份、败酱草25份、蒲公英5份、熟地10份、金银花20份、刺蒺藜8份、川芎6份、蔓荆子8份、细辛9份、薄荷9份、甘草11份、白头翁14份、豨莶草12份。
所述治疗慢性鼻窦炎的中药组合物的制备方法,步骤如下:
1)称取桔梗、柴胡、辛夷花、蔓荆子、细辛、薄荷、甘草、白头翁,加入15倍量的食用酒精,浸泡2h后,加热回流提取2h,过滤,获得第一提取液,将滤渣再次加入8倍量的食用酒精,浸泡1h后,加热回流提取1h,过滤,获得第二提取液,将第一提取液与第二提取液合并,获得提取总液,备用;
2)称取豨签草,加入10倍量的食用酒精,浸泡3h后,超声波提取60min,获得超声波提取液,备用;
3)称取苍耳子、连翘、路路通、败酱草、蒲公英、熟地、金银花、刺蒺藜、川芎,加入12倍量的水,浸泡2h后,煮沸2h,分离一次煎煮液,将药渣再次加入8倍量的水,浸泡2h后,煮沸1h,分离二次煎煮液,将一次煎煮液和二次煎煮液合并,过滤,获得煎煮总液;
4)将提取总液、超声波提取液和煎煮总液合并,混合均匀,并在蒸发器中蒸发浓缩为稠膏;
5)将稠膏烘干后粉碎,过200目筛,将获得的细末加入适量淀粉及糊精,制成胶囊。
临床试验
1、在患者自愿的情况下,选取确诊的慢性鼻窦炎患者104例,年龄在17-63岁,平均年龄30.5岁,病程在半年到10年间。
2、诊断标准参照《实用耳喉鼻科学》中“慢性鼻窦炎”诊断标准拟定。(1)症状:鼻塞、流脓、嗅觉减退或者消失,且多伴有头痛、头晕、头胀。(2)体征:鼻道中有脓性分泌物流出,鼻甲肥大、水肿或者息肉样改变。(3)辅助检查:所有病例均摄柯、华氏X线片检查显示符合慢性鼻窦炎性改变。排除鼻窦其它性质病变。
3、治疗方法
确诊的104例慢性鼻窦炎患均服用实施例3所制备的胶囊,每日三次,每次2粒,10天一个疗程,治疗5个疗程后,统计治疗结果。
4、疗效判断
治愈:症状消失,鼻内镜检查窦口开放良好,窦腔茹膜上皮化,无脓性分泌物;
好转:症状明显改善,鼻内镜检查见窦腔勤膜部分区域水肿、肥厚或肉芽组织形成,有少量脓性分泌物;
无效:症状改善,鼻内镜检查见术腔粘连、窦口狭窄或闭锁、息肉形成,有脓性分泌物。
5、治疗结果
104例患者经5个疗程治疗后,治愈86例,好转16例,无效2例,治愈率为82.7%,总有效率为98%。
6、不良反应
治疗过程中,104例患者均未发现与药物相关的不良反应。
本发明制备的中药组合物对鼻窦炎疗效显著,与西药相比,其无耐药性及毒副作用,且能够彻底治愈鼻窦炎,治愈后不易复发。与手术治疗相比,更容易被患者接受,且成本较低。
上面对本发明的较佳实施方式作了详细说明,但是本发明并不限于上述实施方式,在本领域的普通技术人员所具备的知识范围内,还可以在不脱离本发明宗旨的前提下作出各种变化。
Claims (5)
1.一种治疗慢性鼻窦炎的中药组合物,其特征在于,由以下按照重量份的原料组成:桔梗12-16份、柴胡7-10份、辛夷花15-19份、苍耳子8-11份、连翘12-16份、路路通10-13份、败酱草20-25份、蒲公英3-5份、熟地7-10份、金银花16-20份、刺蒺藜5-8份、川芎4-6份、蔓荆子5-8份、细辛5-9份、薄荷7-9份、甘草8-11份、白头翁10-14份、豨莶草9-12份。
2.根据权利要求1所述的治疗慢性鼻窦炎的中药组合物,其特征在于,由以下按照重量份的原料组成:桔梗13-14份、柴胡8-9份、辛夷花16-18份、苍耳子9-10份、连翘13-15份、路路通11-12份、败酱草21-24份、蒲公英4-5份、熟地8-9份、金银花17-19份、刺蒺藜6-7份、川芎4-5份、蔓荆子6-7份、细辛6-8份、薄荷7-8份、甘草9-10份、白头翁11-13份、豨莶草10-11份。
3.根据权利要求2所述的治疗慢性鼻窦炎的中药组合物,其特征在于,由以下按照重量份的原料组成:桔梗14份、柴胡8份、辛夷花17份、苍耳子9份、连翘14份、路路通12份、败酱草23份、蒲公英4份、熟地9份、金银花18份、刺蒺藜7份、川芎5份、蔓荆子6份、细辛7份、薄荷8份、甘草10份、白头翁12份、豨莶草11份。
4.一种如权利要求1-3任一所述的治疗慢性鼻窦炎的中药组合物的制备方法,其特征在于,步骤如下:
1)称取桔梗、柴胡、辛夷花、蔓荆子、细辛、薄荷、甘草、白头翁,加入12-15倍量的食用酒精,浸泡1-2h后,加热回流提取1-2h,过滤,获得第一提取液,将滤渣再次加入6-8倍量的食用酒精,浸泡0.5-1h后,加热回流提取0.5-1h,过滤,获得第二提取液,将第一提取液与第二提取液合并,获得提取总液,备用;
2)称取豨签草,加入8-10倍量的食用酒精,浸泡2-3h后,超声波提取55-60min,获得超声波提取液,备用;
3)称取苍耳子、连翘、路路通、败酱草、蒲公英、熟地、金银花、刺蒺藜、川芎,加入10-12倍量的水,浸泡1-2h后,煮沸1-2h,分离一次煎煮液,将药渣再次加入6-8倍量的水,浸泡1-2h后,煮沸0.5-1h,分离二次煎煮液,将一次煎煮液和二次煎煮液合并,过滤,获得煎煮总液;
4)将提取总液、超声波提取液和煎煮总液合并,混合均匀,并在蒸发器中蒸发浓缩为稠膏;
5)将稠膏烘干后粉碎,过150-200目筛,将获得的细末加入适量淀粉及糊精,制成片剂或胶囊。
5.如权利要求1-3任一所述的中药组合物在制备治疗慢性鼻窦炎药物中的用途。
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CN102552556A (zh) * | 2012-03-05 | 2012-07-11 | 哈尔滨济博生物技术开发有限公司 | 一种治疗慢性鼻炎的药物 |
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CN102552556A (zh) * | 2012-03-05 | 2012-07-11 | 哈尔滨济博生物技术开发有限公司 | 一种治疗慢性鼻炎的药物 |
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