CN105748307A - Smell-masking oral care composition - Google Patents
Smell-masking oral care composition Download PDFInfo
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- CN105748307A CN105748307A CN201610185381.4A CN201610185381A CN105748307A CN 105748307 A CN105748307 A CN 105748307A CN 201610185381 A CN201610185381 A CN 201610185381A CN 105748307 A CN105748307 A CN 105748307A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention relates to a smell-masking oral care composition, and discloses a spice ingredient for the oral care composition containing metal salt, the composition containing the spice ingredient and a preparing and application method of the composition. The spice ingredient comprises a smell-masking agent containing cinnamyl aldehyde, eugenol and eudesmol and one or more aromatic agents selected from L-menthol, N-ethyl-p-menthyl-3-formamide, anethole, peppermint oil, spearmint oil and wild peppermint oil, and particularly, the metal salt is zinc citrate.
Description
The application is filing date on February 15th, 2011, Application No. 201180067627.3 (international application no is PCT/US2011/024874), the divisional application of the application for a patent for invention of invention entitled " oral care composition of taste masking ".
Background of invention
Just there iing now the demand of the taste profile of the oral care composition improving metalline.
Invention summary
Some embodiments of the present invention provide the fragrance component of the oral care composition for metalline, and described fragrance component includes: odor mask；With one or more aromatic.
Other embodiment provides the composition comprising arbitrary fragrance component described herein.Further embodiment provides preparation and the method using fragrance component described herein and composition.
Detailed Description Of The Invention
As used throughout this article, scope is used as and the writing a Chinese character in simplified form of each and each value in the range of describing.In the range of any value can be selected as the terminal of scope.
All references data is by being incorporated in full herein with reference to it.
When definition in the disclosure and the definition of all references quoted have conflict, it is as the criterion with the disclosure.
In some embodiments, the present invention is provided to the fragrance component of the oral care composition of metalline, comprising: odor mask, including: cinnamic acid, eugenol and eucalyptol；With selected from following one or more aromatic: MENTHOL, N-ethyl-p-menthyl-3-formamide, anethole, peppermint oil, spearmint oil, wild mint oil (corn mint oil)；And two or more combination.
In some embodiments, one or more aromatic at least one be MENTHOL.In some embodiments, one or more aromatic at least one be N-ethyl-p-menthyl-3-formamide.In further embodiment, one or more aromatic at least one be anethole.In another embodiment, one or more aromatic at least one be peppermint oil.Other other embodiments provide fragrance component, wherein one or more aromatic at least one be spearmint oil.And other embodiment provide fragrance component, wherein one or more aromatic at least one be wild mint oil.
Some embodiments comprise the MENTHOL being more than 29.5% by weight.Other embodiment comprises the N-ethyl-p-menthyl-3-formamide being more than 4.5% by weight.Further embodiment comprises the anethole being less than 14.5% by weight.In some embodiments, fragrance component comprises the peppermint oil being less than 40.5% by weight.The embodiment also having other comprises the spearmint oil being less than 5.5% by weight.Some embodiments comprise the wild mint oil being more than 4.5% by weight.
In some embodiments, the present invention is provided to the fragrance component of the oral care composition of metalline, it comprises: MENTHOL, N-ethyl-p-menthyl-3-formamide, anethole, cinnamic acid, eugenol, eucalyptol, peppermint oil, spearmint oil and wild mint oil.
Some embodiments provide fragrance component, comprise: the MENTHOL more than 29.5% by weight；N-ethyl-p-menthyl-3-formamide more than 4.5% by weight；Anethole less than 14.5% by weight；Cinnamic acid more than 0.1% by weight；Eugenol more than 0.1% by weight；Eucalyptol more than 0.5% by weight；Peppermint oil less than 40.5% by weight；Spearmint oil less than 5.5% by weight；Wild mint oil more than 4.5% by weight.
In some embodiments, fragrance component comprises: by weight from the MENTHOL of about 30 to about 50%；By weight from the N-ethyl of about 5 to about 10%-p-menthyl-3-formamide；By weight from the anethole of about 5 to about 14%；By weight from the cinnamic acid of about 0.1 to about 1%；By weight from the eugenol of about 0.1 to about 1%；By weight from the eucalyptol of about 1 to about 5%；By weight from the peppermint oil of about 20 to about 40%；By weight from the spearmint oil of about 1 to about 5%；Wild mint oil from about 5 to about 10% by weight.
Some embodiments provide fragrance component to comprise: by weight from the MENTHOL of about 35 to about 45%；By weight from the N-ethyl of about 5 to about 8%-p-menthyl-3-formamide；By weight from the anethole of about 8 to about 12%；By weight from the cinnamic acid of about 0.5 to about 0.9%；By weight from the eugenol of about 0.5 to about 0.9%；By weight from the eucalyptol of about 2 to about 4%；By weight from the peppermint oil of about 22 to about 27%.
Some embodiments provide oral care composition, and it comprises: arbitrary fragrance component described herein；One or more slaine selected from following: zinc salt, calcium salt, mantoquita, molysite, magnesium salts, manganese salt；And the combination of two or more；With oral cavity acceptable carrier.
In some embodiments, at least one one or more slaines are selected from following zinc salt: zinc oxide, zinc sulfate, zinc chloride, zinc citrate, zinc lactate, zinc gluconate, zinc malate, zinc tartrate, zinc carbonate, trbasic zinc phosphate；And two or more combination.In some embodiments, described zinc salt is selected from: zinc oxide, zinc citrate, zinc gluconate, zinc lactate；And two or more combination.In another embodiment, described zinc salt is selected from: zinc oxide, zinc citrate；And two or more combination.In some embodiments, described zinc salt is zinc citrate.
In some embodiments, slaine is to exist from the concentration of about 0.01% to about 5% based on the weight of composition.In another embodiment, slaine exists by concentration from about 0.1 to about 4% based on the weight of composition.And other embodiment provides composition, slaine therein exists with concentration from about 1 to about 3% by weight.In some embodiments, slaine by based on the weight of composition about 2% concentration exist.
In some embodiments, perfume oil ingredient exists with concentration from about 0.5 to about 2.5% by weight.Some embodiments provide composition, and perfume oil ingredient therein exists with concentration from about 0.8 to about 1.5% by weight.Other embodiment provides composition, and perfume oil ingredient therein exists with the concentration of by weight about 1%.
In some embodiments, described composition comprises selected from following one or more components further: fluoride sources, tartar control agents, buffer, grinding agent, and two or more combination.In some embodiments, one or more components at least one be selected from following fluoride sources: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, prodan, ammonium fluosilicate, amine fluoride, ammonium fluoride, and two or more combination.
Include the amount of fragrance component in the composition of metalline in, typically and be functionally described as effectively sheltering the amount of the taste of slaine.In some embodiments, fragrance component alleviates the negative characteristics of slaine, and the consumer's acceptance level to product that do not detracts.
Other optional additives can be included.In such optional additive, the additive of following characteristic is provided: to change outward appearance or aesthetic appeal including those, and/or make final products anticorrosion, and/or for taste/cosmetics demand and/or as treating and preventing the composition of oral health, preventing or treat that oral cavity is hard or the illness of soft tissue or disorder, or prevention or treat physiologic disorders or illness.
nullColouring agent，Such as dyestuff can be that Food Drug & Cosmetic Act permits at present、Food colour additive for food and oral drug，Including dyestuff，Such as FD&C Red No. 3 (red No. 3 of FD&C) (sodium salt of tetraiodofluorescein)、Food Red 17 (Food Red 17)，6-hydroxyl-5-{ (2-methoxyl group-5-methyl-4-sulfophenyl) azo } disodium salt of the n-naphthalene sulfonic acids of-2-、Food Yellow 13 (yellow No. 13 of food)，The sodium salt of the mixture of quinophthalone (quinophtalone) or the list of 2-(2-quinolyl) indandione and disulfonic acid、FD&C Yellow No. 5 (FD&C Sunset Yellow FCF) (sodium salt of 4-p-sulfophenyl azo-1-p-sulfophenyl-5-hydroxypyrazoles-3 carboxylic acid)、FD&C Yellow No. 6 (FD&C yellow 6) (sodium salt of p-sulfophenyl azepine-B-naphthols-6-list sulphonic acid ester)、FD&C Green
3 No. (green No. 3 of FD&C) (4-{ [4-(N-ethyl-p-sulphur benzylamino)-phenyl]-(4-hydroxyl-2-sulfonium phenyl)-methylene }-[disodium salt of 1-(N-ethyl-N-p-sulphur benzyl)-.DELTA.-3,5-ring-hexadiene imines], FD&C Blue No. 1 (blue No. 1 of FD&C) (disodium salt of dibenzyl diethyl-diaminourea-triphenylcarbinol trisulfonic acid acid anhydride), FD&C Blue No. 2 (blue No. 2 of FD&C) (sodium salt of indigo disulfonic acid) and the mixture of its various ratios.Typically, if including colouring agent, then it exists with the least amount.
Sweetener includes natural and artificial sweetener.Suitable sweetener includes water-soluble sweetening agent; such as monosaccharide, disaccharide class and polysaccharide; such as wood sugar, ribose, glucose (dextrose), mannose, galactolipin, fructose (levulose), sucrose (sugared), maltose; water-soluble artificial sweetener; such as soluble sugar refined salt; i.e.; saccharin salt sodium or calcium, cyclamate dipeptide-based sweetener; as come from the sweetener of L-Aspartic acid, such as L-aspartyl L-phenylaianine methyl esters (Aspartame).Usually, the sweetener of effective dose, it is used to provide for the sweetness level required for particular composition, will depend upon which selected sweetener.This amount will normally be about 0.001% to about 5% based on the weight of composition.In some embodiments, sweetener is saccharin sodium the amount existence by based on the weight of composition about 0.01%.
Optional flavorants can be provided.The acceptable flavorants in any oral cavity can be used, include, but are not limited to zinc salt, such as zinc gluconate, zinc citrate and zinc chlorite, irisone and mixture thereof.Optionally effectively to make the total amount of breath freshening there is one or more flavorants.
Composition can optionally include tartar control (anti-calculus dentalis) agent.Tartar control agents useful herein includes phosphate and polyphosphate (such as pyrophosphate), poly amino propane sulfonic acid (polyaminopropanesulfonic acid)
(AMPS), polyolefm sulfonates, polyolefin phosphates, diphosphonate, such as azacycloparaffin-2,2-diphosphonate (as, azepan-2,2-diphosphonic acid), N-methyl azacyclopentane-2,3-diphosphonic acid, ethane-1-hydroxyl-1,1-diphosphonic acid (EHDP) and ethane-1-amino-1,1-diphosphonate, phosphorous acidic group alkanoic acid and the salt of these reagent any, such as their alkali metal and ammonium salt.Useful inorganic phosphate and polyphosphate include single alkali valency, bibasic and three alkali valency sodium phosphates, sodium tripolyphosphate, four Quadrafos, sodium pyrophosphate, disodium pyrophosphate, Sodium phosphate (Na3HP2O7) and tetrasodium pyrophosphate, sodium trimetaphosphate (sodium trimetaphosphate), calgon and mixture thereof, and sodium therein can optionally be replaced by potassium or ammonium.Other useful anti-calculus agent includes polycarboxylate (ester) polymer and polyvinyl methyl ethermaleic anhydride/maleic anhydride (PVME/MA) copolymer, and such as from ISP, Wayne, N.J are at GantrezTMUnder trade mark obtainable those.
In some embodiments, tartar control agents with by weight from about 0.01 to 10% concentration exist.In some embodiments, tartar control agents exists with the concentration of by weight about 1%.In some embodiments, sodium dihydrogen phosphate exists with concentration from about 0.01 to about 5% by weight.In some embodiments, sodium dihydrogen phosphate exists with the concentration of by weight about 1%.In some embodiments, disodium hydrogen phosphate exists with concentration from about 0.01 to about 5% by weight.In some embodiments, disodium hydrogen phosphate exists with the concentration of by weight about 0.15%.
Other optional additives include antimicrobial (e.g., antibacterial) agent.The acceptable antimicrobial in any oral cavity can be used, including triclosan (5-chloro-2-(2,4-dichlorobenzene epoxide) phenol)；Zinc and stannous ion source；Quaternary ammonium compound, such as Cetylpyridinium Chloride (CPC)；Biguanides, such as chlorhexidine；And benzalkonium chloride.The more exemplary list of the antiseptic being provided with in the U.S. Patent number 5,776,435 of Gaffar etc..
Antioxidant is another kind of optional additive.The acceptable antioxidant in any oral cavity can be used, including Butylated Hydroxyanisole (BHA), Butylated Hydroxytoluene (BHT), vitamin A, carotenoid, vitamin E, flavonoids, polyphenol, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and mixture.
Also optional saliva stimulant can be comprised, for such as improving dry.The acceptable saliva stimulant in any oral cavity can be used, include, but are not limited to food acids, such as citric acid, lactic acid, malic acid, succinic acid, ascorbic acid, adipic acid, fumaric acid and tartaric acid, and mixture.Optionally there is one or more saliva stimulant with effective saliva summation of stimuli.
Optionally comprise anti-plaque and generate (as destroyed bacterial plaque) agent.The acceptable anti-plaque in any oral cavity can be used to generate agent, including, but it is not limited to tin, copper, magnesium and strontium salt, dimethicone copolyol, such as cetyl dimethicone copolyol, papain, glucoamylase, glucose oxidase, urea, calcium lactate, glycerine calcium phosphate, polyacrylic acid strontium and mixture thereof.
Optional desensitizer includes potassium citrate, potassium chloride, potassium tartrate, saleratus, potassium oxalate, potassium nitrate, strontium salt, and mixture.
Optionally, inorganic or naturally occurring or synthetic thickener or gelling agent can be there is.In some embodiments, the amount that thickener or gelling agent exist is by weight from about 0.10 to about 5%, or by weight from about 0.2 to about 1%.The most useful suitable thickener or gelling agent include, such as, but are not limited to inorganic thickening silica, such as from Huber
Corporation is at 165 times obtainable amorphous silicas of trade name Zeodent, Irish moss (Irish moss), ι (iota)-carrageenan, bassora gum and PVP.
In some embodiments, composition comprises dental abrasive or the combination of dental abrasive known in the art.The grinding agent being suitable for the present composition includes, but are not limited to silica, the aluminum oxide of calcining, sodium acid carbonate, calcium carbonate, dicalcium phosphate and calcium pyrophosphate.If comprised, grinding agent typically exists with concentration from about 3 to about 50% by weight.
In some embodiments, surfactant is in the present composition.The suitable example of surfactant includes the water soluble salt of higher fatty acid monoglyceride ester Monosulfate, the such as sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acid, Cocoamidopropyl betaine, higher alkyl sulfates, such as NaLS, alkylaryl sulfonates, such as neopelex, senior alkyl sulfonation acetic acid esters, laruyl alcohol sulfoacetic acid ester sodium, 1, the high-grade aliphatic ester of 2-dihydroxypropane sulphonic acid ester and the most saturated higher aliphatic acylamide of lower aliphatic amino carboxylic acid compound, such as there are in aliphatic acid 12 to 16 carbon, those of alkyl or aryl etc..The example finally mentioning acid amides is N-lauroyl sarcosine and N-lauroyl, N-myristoyl, or sodium, potassium and the ethanolamine salt of N-hexadecanoyl methyl amimoacetic acid.
If comprising surfactant, then surfactant typically exists by concentration from about 0.1 to about 5% based on the weight of composition.In some embodiments, surfactant exists by concentration from about 0.5 to about 4% based on the weight of composition.In some embodiments, surfactant exists by concentration from about 1 to about 3% based on the weight of composition.In some embodiments, surfactant by based on the weight of composition about 2% concentration exist.
For the purpose illustrated, such as glycerine, sorbierite, polyethylene glycol mixing, until mixture becomes homogeneous gel phase, the composition of the present invention can be prepared by making water, wetting agent in conventional mixer.In this gel phase add slaine and, if comprised, grinding agent (s) etc..These compositions are made to mix until obtaining homogeneous phase.Thereafter add fragrance component as described herein to add together with any thickener, colouring agent and surfactant, make all compositions mix under about 20 to the 100 middle and high speed of mmHg vacuum.
Further describe embodiment of the present invention below in an example.These embodiments are only illustrative, and and limit as described never in any form and the scope of the invention of claim.
Embodiment
Embodiment
1
Being shown in table 1 below according to the fragrance component (1-11) of the present invention, the amount of component represents with weight %.Can be through being prepared by conventional methods these fragrance components.
Table
1
Embodiment
2
The exemplary present composition (composition I) and the formula of two comparing embodiments (composition X and Y) is described at table 2 (below).
Table
2
Use at home in consumer acceptability's research and evaluate composition I, X and Y.The result of research proves, compares the composition using the similar formula being different from those fragrance components described herein, and the fragrance component of the exemplary present invention provides the consumer acceptability improved.
Claims (10)
1. an oral care composition, it comprises:
A) fragrance component, described fragrance component includes:
I) odor mask, described odor mask comprises: cinnamic acid, eugenol and eucalyptol；With
Ii) one or more are selected from following aromatic: MENTHOL, N-ethyl-p-menthyl-3-formamide, anethole, Fructus Piperis peppermint oil, spearmint oil, Japanese peppermint oil, and the combination of two or more；
B) zinc oxide and zinc citrate；With
C) oral cavity acceptable carrier；
Wherein said fragrance component exists with concentration from about 0.5 to about 2.5% by weight；
The total concentration of zinc oxide and zinc citrate is from about 0.01 to about 5% based on the weight of composition；
Described fragrance component comprises the cinnamic acid being more than 0.1% by weight, is more than the eugenol of 0.1% by weight and is more than the eucalyptol of 0.5% by weight,
One or more aromatic preferably described at least one be MENTHOL,
One or more aromatic preferably described at least one be N-ethyl-p-menthyl-3-formamide,
One or more aromatic preferably described at least one be anethole,
One or more aromatic preferably described at least one be Fructus Piperis peppermint oil,
One or more aromatic preferably described at least one be spearmint oil,
One or more aromatic preferably described at least one be Japanese peppermint oil.
2. the composition of claim 1, comprises the MENTHOL by weight more than 29.5%,
Preferably comprise the N-ethyl-p-menthyl-3-formamide by weight more than 4.5%,
Preferably comprise the anethole by weight less than 14.5%,
Preferably comprise the Fructus Piperis peppermint oil by weight less than 40.5%,
Preferably comprise the spearmint oil by weight less than 5.5%,
Preferably comprise the Japanese peppermint oil by weight more than 4.5%.
3. the composition of claim 1, wherein said fragrance component comprises:
MENTHOL more than 29.5% by weight；
N-ethyl-p-menthyl-3-formamide more than 4.5% by weight；
Anethole less than 14.5% by weight；
Cinnamic acid more than 0.1% by weight；
Eugenol more than 0.1% by weight；
Eucalyptol more than 0.5% by weight；
Fructus Piperis peppermint oil less than 40.5% by weight；
Spearmint oil less than 5.5% by weight；With
Japanese peppermint oil more than 4.5% by weight.
4. the composition of claim 3, wherein said fragrance component comprises:
By weight from the MENTHOL of about 30 to about 50%；
By weight from the N-ethyl of about 5 to about 10%-p-menthyl-3-formamide；
By weight from the anethole of about 5 to about 14%；
By weight from the cinnamic acid of about 0.1 to about 1%；
By weight from the eugenol of about 0.1 to about 1%；
By weight from the eucalyptol of about 1 to about 5%；
By weight from the Fructus Piperis peppermint oil of about 20 to about 40%；
By weight from the spearmint oil of about 1 to about 5%；With
By weight from the Japanese peppermint oil of about 5 to about 10%.
5. claim 3 or the composition of claim 4, wherein said fragrance component comprises:
By weight from the MENTHOL of about 35 to about 45%；
By weight from the N-ethyl of about 5 to about 8%-p-menthyl-3-formamide；
By weight from the anethole of about 8 to about 12%；
By weight from the cinnamic acid of about 0.5 to about 0.9%；
By weight from the eugenol of about 0.5 to about 0.9%；
By weight from the eucalyptol of about 2 to about 4%；With
By weight from the Fructus Piperis peppermint oil of about 22 to about 27%.
6. the composition any one of claim 1 to 5, wherein the total concentration of zinc oxide and zinc citrate be by weight from 1 to 3% concentration exist.
7. the composition any one of claim 1 to 6, fragrance component therein exists with concentration from about 0.8 to about 1.5% by weight.
8. the composition any one of claim 1 to 7, it also comprises selected from one or more following components: fluoride sources, tartar control agents, buffer, grinding agent；And the combination of two or more.
9. according to the composition any one of claim 1 to 8, one or more components wherein said at least one be selected from following fluoride sources: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, prodan, ammonium fluosilicate, amine fluoride, ammonium fluoride, and the combination of two or more.
10., according to the composition of claim 1, essentially according to described in embodiment before, get rid of any comparative example existed.
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| CN201610185381.4A CN105748307A (en) | 2011-02-15 | 2011-02-15 | Smell-masking oral care composition |
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| CN201610185381.4A CN105748307A (en) | 2011-02-15 | 2011-02-15 | Smell-masking oral care composition |
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| CN201180067627.3A Division CN103354758B (en) | 2011-02-15 | 2011-02-15 | The oral care composition of taste masking |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309148A (en) * | 2016-09-28 | 2017-01-11 | 北京瑞济善健康科技有限公司 | Quickly released oral cavity nursing mouthwash refreshing tablet and preparation method and application thereof |
| CN114159574A (en) * | 2021-12-09 | 2022-03-11 | 郑州味千生物技术有限公司 | Product for masking bitter or off-flavors |
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| US6306372B1 (en) * | 2000-06-21 | 2001-10-23 | Noville Inc. | Oral hygiene compositions which mask the burn sensation and the astringency of eucalyptol and zinc |
| CN1333674A (en) * | 1998-11-12 | 2002-01-30 | 布洛克医药公司 | Flavour blend for masking unpleasant taste of zinc compounds |
| JP2003137755A (en) * | 2001-11-02 | 2003-05-14 | Lion Corp | Composition for oral cavity |
| WO2008005548A2 (en) * | 2006-07-07 | 2008-01-10 | The Procter & Gamble Company | Flavors for oral compositions |
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| WO1998011867A1 (en) * | 1996-09-20 | 1998-03-26 | Warner-Lambert Company | Oral compositions containing a zinc compound |
| CN1333674A (en) * | 1998-11-12 | 2002-01-30 | 布洛克医药公司 | Flavour blend for masking unpleasant taste of zinc compounds |
| US6306372B1 (en) * | 2000-06-21 | 2001-10-23 | Noville Inc. | Oral hygiene compositions which mask the burn sensation and the astringency of eucalyptol and zinc |
| JP2003137755A (en) * | 2001-11-02 | 2003-05-14 | Lion Corp | Composition for oral cavity |
| WO2008005548A2 (en) * | 2006-07-07 | 2008-01-10 | The Procter & Gamble Company | Flavors for oral compositions |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309148A (en) * | 2016-09-28 | 2017-01-11 | 北京瑞济善健康科技有限公司 | Quickly released oral cavity nursing mouthwash refreshing tablet and preparation method and application thereof |
| CN106309148B (en) * | 2016-09-28 | 2019-04-26 | 北京瑞济善健康科技有限公司 | Quick-release oral care is gargled freshening tablet and its preparation method and application |
| CN114159574A (en) * | 2021-12-09 | 2022-03-11 | 郑州味千生物技术有限公司 | Product for masking bitter or off-flavors |
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Application publication date: 20160713 |