CN105748047A - Minitype wireless pyrogen measuring instrument for pharmacological animal experiment - Google Patents
Minitype wireless pyrogen measuring instrument for pharmacological animal experiment Download PDFInfo
- Publication number
- CN105748047A CN105748047A CN201610085383.6A CN201610085383A CN105748047A CN 105748047 A CN105748047 A CN 105748047A CN 201610085383 A CN201610085383 A CN 201610085383A CN 105748047 A CN105748047 A CN 105748047A
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- Prior art keywords
- pyrogen
- measuring instrument
- manufacture method
- micro radio
- statistics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
- A61B5/0008—Temperature signals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
Abstract
The invention discloses a minitype wireless pyrogen measuring instrument for a pharmacological animal experiment.A high-sensitivity integrated temperature sensor is used for manufacturing a wireless temperature measuring system with high sensitivity, reliability and capacity, and therefore precision and stability of data obtained after pyrogen data collected on site is converted into voltage signals are guaranteed.By means of establishment of the novel pyrogen measuring software system, temperature information of multiple nodes will be collected for statistics, summarizing and analysis, the result is displayed visually and intuitively, and meanwhile the functions of alarming, statistics and probe calibration are achieved.The pyrogen measuring instrument is miniaturized, high in capacity and reliability and capable of achieving visual data processing.
Description
Technical field
The present invention relates to the manufacture method of a kind of pharmacology zoopery micro radio pyrogen measuring instrument, belong to equipment design and manufacturing technology field.
Background technology
Drug safety is related to the healthy of broad masses of the people and life security.According to World Health Organization's rough estimates, in disease medicament treatment in 2013,60% uses intravenous liquid therapeutic modality to carry out；China's transfusion in 2014 1 year has used 10,400,000,000 bottles, is equivalent to everyone defeated 8 bottles of liquid of 1,300,000,000 populations.As can be seen here, intravenous liquid therapeutic modality all plays a very important role in saving patients ' lives or liquid make-up etc., and the pyrogen in injection is the important symbol that injection production is qualified, if injection can cause body pyrogen reaction containing pyrogenic substances, the symptoms such as patient occurs ague, high heat in 0.5～1h, perspires, swoons, vomiting, during high heat, body temperature is up to 40 DEG C, and severe patient even can be suffered a shock.Pyrogen test is by by the test sample of doses, by being injected intravenously in rabbit body, at the appointed time, observing the situation that rabbit body temperature raises, to judge in test sample, whether the limit of contained pyrogenic substances meets a kind of method of regulation.Due to the basic simlarity of the rabbit reaction to pyrogen with people, so since half a century, rabbit pyrogen test is for ensureing that drug quality and human administration play a significant role safely.
Rabbit pyrogen test can reflect the temperature-rise period that thermal source causes mammal complicated, the method not only can detect the pyrogen of bacterial endotoxin, also the endotoxic pyrogen of non-bacterial can be detected, and it is applicable to detect the pyrogenic substances of the complicated kinds such as Chinese medicine preparation, and bacterial endotoxins test is difficult to detection Chinese medicine preparation.The basic using method of pyrogen measuring instrument commonly used on the market now is: fixing rabbit, rabbit anus is inserted with the thermal source temperature measurer with wire, carry out thermometric, by judging before and after rabbit injection that the change of temperature judges that injection is containing pyrogen limit whether conformance with standard.But the drawback of this metering system is in that powerful fixing rabbit, do not measure under a relatively quiet state smoothly, the actions such as rabbit carries the baby due to self, scaring and change body temperature, can not really reflect whether owing to medicine effect causes variations in temperature, rabbit usually comes off due to struggle or damages temperature probe simultaneously so that experiment must re-start；Moreover the facility of fixing rabbit reuses, rabbit excrement repeated contamination, it is easy to breed bacteria etc., causes measurement result unstability.
The series of malpractice that traditional pyrogen measuring instrument exists, the verity of heat source check result, reliability are had a strong impact on, test period is long simultaneously, number of repetition is many, the demand of current a large amount of thermal source experiments of measuring can not be met, therefore in the urgent need to a kind of novel easy to use, result thermal source measuring instrument accurately and reliably.Based on background above, it is contemplated that develop a kind of pharmacological research equipment for injecting drug use pyrogen test: by observing the micro radio thermal source measuring instrument that animal rabbit body temperature is affected by medicine.By developing micro radio pyrogen measuring instrument so that need not fix rabbit during measurement, being allowed to condition under the natural feeding state of rabbit-hutch and measure, the body temperature at this moment measured is nearest from true value, can reflect the true body temperature of rabbit.The miniature temperature transducer inserted in rabbit body carries out transmission of wireless signals by the data processing platform (DPP) of wireless communication chips Yu control centre, data processing platform (DPP) passes through radio receiver, the temperature signal Real-time Collection launched by temperature transducer, collects the related data of needs by special-purpose software and carries out necessary analysis.
The new micro wireless pyrogen measuring instrument of present invention research and development, the pyrogen of injection can be measured more accurately, at utmost avoid repeated trials, exploitation by the application of the present computer technology and communication technology and software design, make measurement, calculate, add up more accurate, can better judging that whether injection pyrogen is qualified, thus avoiding patient to reflect because of pyrogen, maximum possible must save patients ' lives.
Summary of the invention
It is an object of the invention to manufacture and design a kind of pharmacology zoopery micro radio pyrogen measuring instrument, finally give excellent performance, measure measurement instrument convenient, result miniaturized intelligent accurately.
The manufacture method of a kind of pharmacology zoopery micro radio pyrogen measuring instrument of the present invention, it is adopt wireless transmission method, eliminate original measurement line, new type measuring instrument considers the collaborative work of the multiple assemblies such as temperature transducer, wireless transport module, power supply, and measure the toleration of animal recipient, comfortableness etc., accomplish miniaturization, low-power consumption.
The manufacture method of above-mentioned a kind of pharmacology zoopery micro radio pyrogen measuring instrument, it is characterized in that: consider that the size of animal participating in measuring is many, various interference that the environment such as raising, experiment exists and with the distance etc. controlling computer, it is necessary to design there is bigger networking capacity, wireless system for transmitting data that capacity of resisting disturbance is strong.
The manufacture method of a kind of pharmacology zoopery micro radio pyrogen measuring instrument of the present invention, it is characterised in that: manufacture and design highly sensitive and jumbo temp measuring system (Fig. 1).
The manufacture method of above-mentioned a kind of pharmacology zoopery micro radio pyrogen measuring instrument, it is characterized in that: temperature measurement accuracy is 0.1 DEG C, thermometric resolution is 0.01 DEG C, 30 DEG C～50 DEG C scopes less than 0.5%, thus ensureing that the data precision of collection in worksite, stability, the linearity are above measurement criteria.
The manufacture method of a kind of pharmacology zoopery micro radio pyrogen measuring instrument of the present invention, it is characterized in that: manufacture and design a kind of visualization data system for handling (Fig. 2), possess the statistics of data, collect, analyze and visual intuitively show data, angularly comprehensively provide testing result from statistics and heating trend, and store and printing test report.
The manufacture method of above-mentioned a kind of pharmacology zoopery micro radio pyrogen measuring instrument, it is characterised in that: visualization data processing software is provided simultaneously with the functions such as warning, statistics and probe calibration, is a visual easy to operate software system.
Accompanying drawing explanation
Fig. 1 transmitting terminal design principle figure
Fig. 2 receiving terminal design principle figure
Detailed description of the invention
Embodiment:
The manufacture method of described a kind of pharmacology zoopery micro radio pyrogen measuring instrument: adopt wireless transmission method, eliminate original measurement line, new type measuring instrument considers the collaborative work of the multiple assemblies such as temperature transducer, wireless transport module, power supply, consider that the size of animal participating in measuring is many, various interference that the environment such as raising, experiment exists and with the distance etc. controlling computer, need to design there is bigger networking capacity, wireless system for transmitting data that capacity of resisting disturbance is strong, participate in accompanying drawing explanation in detail.
Manufacturing and designing highly sensitive and jumbo temp measuring system, temperature measurement accuracy is 0.1 DEG C, and thermometric resolution is 0.01 DEG C, 30 DEG C～50 DEG C scopes less than 0.5%, thus ensureing that the data precision of collection in worksite, stability, the linearity are above measurement criteria.
Manufacture and design a kind of visualization data system for handling (Fig. 2), possess the statistics of data, collect, analyze and visual intuitively show data, testing result is angularly comprehensively provided from statistics and heating trend, and store and printing test report, visualization data processing software is provided simultaneously with the functions such as warning, statistics and probe calibration, is a visual easy to operate software system.
Equipment field survey finds, this temperature measurer is easy and simple to handle, excellent performance, and data analysis reliably and visualizes, and is a kind of intelligence measurement device of facilitating miniaturization.
Claims (6)
1. the pharmacology zoopery manufacture method of micro radio pyrogen measuring instrument, adopt wireless transmission method, eliminate original measurement line, new type measuring instrument considers the collaborative work of the multiple assemblies such as temperature transducer, wireless transport module, power supply, and measure the toleration of animal recipient, comfortableness etc., accomplish miniaturization, low-power consumption.
2. a pharmacology zoopery manufacture method for micro radio pyrogen measuring instrument, manufactures and designs highly sensitive and jumbo temp measuring system (Fig. 1).
3. the pharmacology zoopery manufacture method of micro radio pyrogen measuring instrument, manufacture and design a kind of visualization data system for handling (Fig. 2), possess the statistics of data, collect, analyze and visual intuitively show data, angularly comprehensively provide testing result from statistics and heating trend, and store and printing test report.
4. the manufacture method of a kind of pharmacology zoopery micro radio pyrogen measuring instrument according to claim 1, it is characterized in that: consider that the size of animal participating in measuring is many, various interference that the environment such as raising, experiment exists and with the distance etc. controlling computer, it is necessary to design there is bigger networking capacity, wireless system for transmitting data that capacity of resisting disturbance is strong.
5. the manufacture method of a kind of pharmacology zoopery micro radio pyrogen measuring instrument according to claim 2, it is characterized in that temperature measurement accuracy is 0.1 DEG C, thermometric resolution is 0.01 DEG C, 30 DEG C～50 DEG C scopes less than 0.5%, thus ensureing that the data precision of collection in worksite, stability, the linearity are above measurement criteria.
6. the manufacture method of a kind of pharmacology zoopery micro radio pyrogen measuring instrument according to claim 3, it is characterized in that: visualization data processing software is provided simultaneously with the functions such as warning, statistics and probe calibration, is a visual easy to operate software system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610085383.6A CN105748047A (en) | 2016-02-15 | 2016-02-15 | Minitype wireless pyrogen measuring instrument for pharmacological animal experiment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610085383.6A CN105748047A (en) | 2016-02-15 | 2016-02-15 | Minitype wireless pyrogen measuring instrument for pharmacological animal experiment |
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| CN105748047A true CN105748047A (en) | 2016-07-13 |
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| CN201610085383.6A Pending CN105748047A (en) | 2016-02-15 | 2016-02-15 | Minitype wireless pyrogen measuring instrument for pharmacological animal experiment |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034805A (en) * | 1988-02-05 | 1989-08-16 | 清华大学 | A kind of automatic heat-original determinating and processing instrument |
| CN1056580A (en) * | 1990-05-11 | 1991-11-27 | 田边制药株式会社 | Measure the method for pyrogen content |
| CN2155204Y (en) * | 1993-04-23 | 1994-02-09 | 程小林 | Rabbit-fettering appliance for heat source examination |
| CN101477103A (en) * | 2009-01-05 | 2009-07-08 | 范能全 | Full-pyrogen detection method for pyrogenicsubstance content in injection |
| CN104622435A (en) * | 2015-02-06 | 2015-05-20 | 山东省食品药品检验研究院 | Pyrogen inspection instrument and inspection method based on implanted type body temperature telemetry technology |
-
2016
- 2016-02-15 CN CN201610085383.6A patent/CN105748047A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034805A (en) * | 1988-02-05 | 1989-08-16 | 清华大学 | A kind of automatic heat-original determinating and processing instrument |
| CN1056580A (en) * | 1990-05-11 | 1991-11-27 | 田边制药株式会社 | Measure the method for pyrogen content |
| CN2155204Y (en) * | 1993-04-23 | 1994-02-09 | 程小林 | Rabbit-fettering appliance for heat source examination |
| CN101477103A (en) * | 2009-01-05 | 2009-07-08 | 范能全 | Full-pyrogen detection method for pyrogenicsubstance content in injection |
| CN104622435A (en) * | 2015-02-06 | 2015-05-20 | 山东省食品药品检验研究院 | Pyrogen inspection instrument and inspection method based on implanted type body temperature telemetry technology |
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Application publication date: 20160713 |
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