CN105732247B - 一种应用乙酰丙酮铜合成医药中间体菲化合物的方法 - Google Patents
一种应用乙酰丙酮铜合成医药中间体菲化合物的方法 Download PDFInfo
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- CN105732247B CN105732247B CN201610217169.1A CN201610217169A CN105732247B CN 105732247 B CN105732247 B CN 105732247B CN 201610217169 A CN201610217169 A CN 201610217169A CN 105732247 B CN105732247 B CN 105732247B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
- C07B37/10—Cyclisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/266—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions of hydrocarbons and halogenated hydrocarbons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2/00—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms
- C07C2/86—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by condensation between a hydrocarbon and a non-hydrocarbon
- C07C2/861—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by condensation between a hydrocarbon and a non-hydrocarbon the non-hydrocarbon contains only halogen as hetero-atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/127—Preparation from compounds containing pyridine rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610217169.1A CN105732247B (zh) | 2015-03-06 | 2015-03-06 | 一种应用乙酰丙酮铜合成医药中间体菲化合物的方法 |
Applications Claiming Priority (2)
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CN201610217169.1A CN105732247B (zh) | 2015-03-06 | 2015-03-06 | 一种应用乙酰丙酮铜合成医药中间体菲化合物的方法 |
CN201510100568.5A CN104692986B (zh) | 2015-03-06 | 2015-03-06 | 一种医药中间体菲类化合物的合成方法 |
Related Parent Applications (1)
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CN201510100568.5A Division CN104692986B (zh) | 2015-03-06 | 2015-03-06 | 一种医药中间体菲类化合物的合成方法 |
Publications (2)
Publication Number | Publication Date |
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CN105732247A CN105732247A (zh) | 2016-07-06 |
CN105732247B true CN105732247B (zh) | 2018-09-21 |
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CN201610217169.1A Active CN105732247B (zh) | 2015-03-06 | 2015-03-06 | 一种应用乙酰丙酮铜合成医药中间体菲化合物的方法 |
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CN (1) | CN105732247B (zh) |
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2015
- 2015-03-06 CN CN201610217169.1A patent/CN105732247B/zh active Active
Non-Patent Citations (2)
Title |
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2,3-Dichloro-5,6-dicyano-para-benzoquinone (DDQ)/ Methanesulfonic Acid (MsOH)-Mediated Intramolecular Arene-Alkene Oxidative Coupling;Ko Hoon Kim等;《Advanced Synthesis & Catalysis》;20140220;第356卷(第4期);参见第701页左栏倒数第2行至右栏第3行以及Scheme5 * |
Ligand-Free Heck Reaction: Pd(OAc)2 as an Active Catalyst Revisited;Qingwei Yao等;《The Journal of Organic Chemistry》;20030816;第68卷;第7529-7531页表1-4 * |
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Address after: No. 168, Changjiang Road, Donghu street, Pizhou City, Xuzhou City, Jiangsu Province Co-patentee after: Hu Shuting Patentee after: Huang Zhemin Address before: 518000 21 Nanshan District Deng Liang Road, Shenzhen, Guangdong Co-patentee before: Hu Shuting Patentee before: Huang Zhemin |
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