CN105727231B - 一种缓解肌肉紧张的玫瑰中药组合物及制备方法和应用 - Google Patents
一种缓解肌肉紧张的玫瑰中药组合物及制备方法和应用 Download PDFInfo
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Abstract
本发明属于生物医药技术领域，具体涉及一种用于缓解肌肉紧张的玫瑰中药组合物及制备方法和应用。所述玫瑰中药组合物含有玫瑰花，粉防己，独活，当归，续断，五加皮，红花，芍药，生姜。该玫瑰中药组合物可在制备缓解肌肉紧张或肌肉过度疲劳的药物中应用。
Description
技术领域
本发明属于生物医药领域，具体涉及一种用于缓解肌肉紧张的玫瑰中药组合物及制备方法和应用。
背景技术
计算机、手机等各种现代化电子产品在给人们带来方便的同时，也使人们过于沉迷和依赖于这些电子产品，每天都是面对电脑，手机等电子产品长时间使用，极易导致背部、颈肩部、手腕部肌肉过度疲劳或强直，甚至发生颈椎、肩关节、手腕关节的慢性肌肉损伤的疾病，极大威胁人类健康，严重影响人们的生活、工作。
虽然降低肌肉收缩强度或缓解肌肉过度疲劳药物包括在外科手术中搭配使用的麻醉药品以及肌肉松弛剂等，能减轻痉孪、疼痛、过度反射等症状，如常用的肌肉松弛剂苯二氮平类药物、氯唑沙宗、氯若沙宗等，但长期应用这些药物会引起眩晕、困倦、乏力、恶心、运动能力障碍、皮疹、白细胞减少，严重会引起耐受和依赖性，对人体的副作用极大，因此，提供一种能够在其工作时有效缓解肌肉紧张或肌肉过度疲劳的药物一直是本领域待解决的问题。
为解决上述问题，本发明现提供一种用于缓解肌肉紧张的玫瑰中药组合物，该玫瑰中药组合物能够舒经活血，缓解肌肉纤维受伤造成的酸痛，缓解肌肉僵硬而致的肌肉疲劳过度。本发明同时提供该玫瑰中药组合物的制备方法及应用。
发明内容
本发明的目的是提供一种用于缓解肌肉紧张的玫瑰中药组合物，该玫瑰中药组合物能够舒经活血，缓解肌肉纤维受伤造成的酸痛，缓解肌肉僵硬而致的肌肉疲劳过度。
本发明的另一个目的是提供上述玫瑰中药组合物的制备方法。
本发明的另一个目的是提供上述玫瑰中药组合物的应用。
本发明所述的上述目的是通过以下技术方案实现的：
一种用于缓解肌肉紧张的玫瑰中药组合物，所述玫瑰中药组合物含有玫瑰花，粉防己，独活，当归，续断，五加皮，红花，芍药，生姜。
一种用于缓解肌肉紧张的玫瑰中药组合物，所述玫瑰中药组合物含有以下重量比的组分：10-20份玫瑰花，6-9份粉防己，10-20份独活，15-25份当归，15-25份续断，10-15份五加皮，15-25份红花，10-15份芍药，15-30份生姜。
所述用于缓解肌肉紧张的玫瑰中药组合物的制备方法如下：
将玫瑰花，粉防己，独活，当归，续断，五加皮，红花，芍药及生姜混匀，加蒸馏水2L，80℃煎熬半小时，重复三次，合并三次水煎液并浓缩制备成膏状，即得所述玫瑰中药组合物。
所述用于缓解肌肉紧张的玫瑰中药组合物可在制备用于缓解肌肉紧张的药物中应用。其中，所述肌肉为背部、颈肩部、手腕部肌肉。
所述用于缓解肌肉紧张的玫瑰中药组合物可在制备缓解肌肉紧张或肌肉过度疲劳的药物中应用。
所述玫瑰中药组合物作为药效成分的药物制剂为霜剂、乳剂、膏剂、粉剂、洗剂、凝胶剂、气雾剂、涂膜剂、酊剂和醑剂。
本发明所述用于缓解肌肉紧张的玫瑰中药组合物，药物组方参考了多种医学药典，克服了禁忌组合的问题，具体选用草药的药理学基础为：
玫瑰花：玫瑰花味甘微苦、性微温，归肝、脾、胃经。玫瑰花含有丰富的天然维生素C、蛋白质、矿物质等。具有非常显著的美容护肤作用，能有效美白、柔软肌肤，抚平细纹，预防皱纹，能促进皮肤再生、令肌肤保持弹性与光泽。适合各种肤质，对皮肤干燥、色斑、疤痕、创伤、烧烫伤、晒伤、湿疹、老化皮肤皆有极佳功效。
粉防己：肉质主根入药，味苦辛性寒，功能祛风除湿、利尿通淋。含多种生物碱，其中粉防己碱治风湿关节炎有效。
独活：味辛、苦，性微温。功能：祛风除湿，痛痹止痛。主治：用于风寒湿痹，要洗疼痛，少阴伏风头痛，风寒挟湿头痛。
当归：性味甘，温。归肝、心、脾经。补血；活血；主治：调经止痛；润燥滑肠。主血虚诸证；月经不调；经闭；痛经；症瘕结聚；崩漏；虚寒腹痛；痿痹；肌肤麻木；肠燥便难；赤痢后重；痈疽疮疡；跌扑损伤。
续断：功效主治：补肝肾，续筋骨，调血脉。治腰背酸痛，足膝无力，胎漏，崩漏，带下，遗精，跌打损伤，金疮，痔漏，痈疽疮肿
五加皮：味辛、苦，性温。有祛风湿，补益肝肾，强筋壮骨，利水消肿的作用。主治：用于风湿痹病，筋骨痿软，小儿行迟，体虚乏力，水肿，脚气。
红花：性味辛、温。入心、肝经。功能：活血通经，去瘀止痛。主治：治经闭，症瘕，难产，死胎，产后恶露不行、瘀血作痛，痈肿，跌扑损伤。
芍药：苦，微寒。归肝经。功能：行瘀、止痛、凉血、消肿。主治：治瘀滞经闭、疝瘕积聚、腹痛、胁痛、衄血、血痢、肠风下血、目赤、痈肿、跌扑损伤。
黄芪：性味：甘，微温。其有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
生姜：味辛，性微温。解表散寒，温中止呕，温肺止咳，解毒。主治：风寒感冒，脾胃寒症，胃寒呕吐，肺寒咳嗽，解鱼蟹毒。
本发明的有益效果：
1、本发明提供的用于缓解肌肉紧张的玫瑰中药组合物，能够舒经活血，缓解肌肉纤维受伤造成的酸痛，缓解肌肉僵硬而致的肌肉疲劳过度，缓解肌肉紧张。
2、本发明提供的用于缓解肌肉紧张的玫瑰中药组合物，从通经活络、舒经活血、整体调理入手，能快速减轻患者痛苦，无副作用。
具体实施方式
实施例1：玫瑰中药组合物高剂量组的制备方法
将20g玫瑰花，9g粉防己，20g独活，25g当归，25g续断，15g五加皮，25g红花，15g芍药，30g生姜按照比例混匀，加蒸馏水2L，80℃煎熬半小时，重复三次，合并三次水煎液并浓缩制备成膏状即得。
实施例2：玫瑰中药组合物中剂量组的制备方法
将15g玫瑰花，8g粉防己，15g独活，20g当归，20g续断，10g五加皮，25g红花，12g芍药，20g生姜按照比例混匀，加蒸馏水2L，80℃煎熬半小时，重复三次，合并三次水煎液并浓缩制备成膏状即得。
实施例3：玫瑰中药组合物低剂量组的制备方法
将10g玫瑰花，6g粉防己，10g独活，15g当归，15g续断，10g五加皮，15g红花，10g芍药，15g生姜按照比例混匀，加蒸馏水2L，80℃煎熬半小时，重复三次，合并三次水煎液并浓缩制备成膏状即得。
实施例4：玫瑰中药组合物的功效验证
1.实验材料
动物：中华大蟾蜍20只，体质量50-80g。由兰州大学实验中心提供。
试剂：含葡萄糖任氏液：20％氯化钠32.5ml，10％氯化钾1.4ml，10％氯化钙1.2ml，5％碳酸氢钠4.0ml，1％磷酸二氢钠1.0ml，葡萄糖2g，蒸馏水加至1000ml。其余为常规试剂。
仪器：RM-6240C型四导生理记录仪，包括放大器、示波器(成都仪器厂)；YSD-4型药理生理多用仪(成都仪器厂)；JH-2型张力换能器(成都仪器厂)。
2.实验组
空白对照组：含葡萄糖任氏液。
黄芪五物汤对照组：将黄芪9g，桂枝9g，芍药9g，生姜18g，大枣4枚按照比例混匀，加蒸馏水2L，80℃煎熬半小时，重复三次，合并三次水煎液并浓缩制备成膏状，即得所述黄芪五物汤对照组。
玫瑰中药组合物高剂量组：制备方法如实施例1。
玫瑰中药组合物中剂量组：制备方法如实施例2。
玫瑰中药组合物低剂量组：制备方法如实施例3。
3.实验步骤
选用蟾蜍制备离体蟾蜍腓肠肌标本15块，随机分为5组，每组3块，用含葡萄糖任氏液冲洗去血污。肌肉收缩能力的测定：将腓肠肌标本放入有电磁搅拌的石蜡肌槽中，并加入25mL任氏液，静置10min后，将肌肉近坐骨神经端用细线固定于肌槽上，另一端经细线连于张力换能器上。调节肌肉处于恒定的张力状态，作为基线描记，银电极触肌肉表面，给予连续方波刺激，在四导生理记录仪上描记肌肉收缩曲线。肌槽温度20℃，刺激参数：DC10V，波宽0.3ms，频率1Hz。在给予刺激约30s后，肌肉收缩幅度达到最大值(Cmax)，停止刺激后用吸管吸出肌槽内的任氏液，实验组分别加入25mL黄芪五物汤对照组，玫瑰中药组合物高剂量组，玫瑰中药组合物中剂量组和玫瑰中药组合物低剂量组；空白对照组加入25mL含葡萄糖任氏液。
搅拌、浸泡15min后，重复给予相同刺激，描记肌肉收缩曲线。观察项目:用药前后肌肉最大收缩幅度，以Ia/Ib(其中Ib为给药前肌肉收缩最大幅度，Ia为给药后肌肉收缩最大幅度)计算增加收缩能力的倍数；肌肉收缩状态持续时间；肌肉收缩达最大幅度所需时间。
4.实验结果
(1)各组用药前后肌肉最大收缩幅度比较
肌肉最大收缩幅度越小，表明药物缓解肌肉紧张的效果越好。
本发明提供的玫瑰中药组合物可显著下调肌肉收缩的最大幅度(P<0.05)。其中，玫瑰中药组合物中、高剂量组对肌肉松弛的作用效果最显著，优于黄芪五物汤对照组的效果，尤其在高剂量组的作用下，浸泡15min之后的蟾蜍腓肠肌不发生明显收缩现象，结果见表1。
表1各组用药前后肌肉最大收缩幅度比较
(2)各组用药前后肌肉收缩状态持续时间比较
肌肉收缩状态持续时间越短，表明药物缓解肌肉紧张的效果越好。
结果表明(表2)，玫瑰中药组合物低、高剂量组用药前后肌肉收缩状态持续时间比较无显著差异性(p＞0.05)，而中剂量组用药前后有显著差异(p＜0.05)。相对于空白对照组和黄芪五物汤对照组用药前后肌肉收缩状态持续时间比值的变化，玫瑰中药组合物各剂量组用药前后肌肉状态持续时间比值显著增大。
表2各组用药前后肌肉收缩状态持续时间比较
(p值 为用药后与用药前比较)
(3)各组用药前后肌肉收缩达最大幅度所需时间比较
用药后肌肉收缩达最大幅度所需时间越长，表明药物缓解肌肉紧张的效果越好。
结果表明(表3)，玫瑰中药组合物低、高剂量组均显著延长了肌肉收缩达最大幅度所需时间，玫瑰中药组合物用药后肌肉收缩达最大幅度所需的时间较用药前明显延长，用药后/用药前的值明显增大，可能通过增加肌肉舒张时间，从而延长肌肉收缩达最大幅度所需时间，玫瑰中药组合物具有使肌肉保持松弛的效果。
表3各组用药前后肌肉收缩达最大幅度所需时间比较
(p值 为用药后与用药前比较)
上述实施例表明，本发明提供的用于缓解肌肉紧张的玫瑰中药组合物能够舒经活血，缓解肌肉纤维受伤造成的酸痛，缓解肌肉僵硬而致的肌肉疲劳过度。可在制备松弛背部、颈肩部、手腕部肌肉的药物中应用，亦可在制备缓解肌肉紧张或肌肉过度疲劳的药物中的应用。
Claims (6)
1.一种用于缓解肌肉紧张的玫瑰中药组合物，其特征在于，所述玫瑰中药组合物含有10-20份玫瑰花，6-9份粉防己，10-20份独活，15-25份当归，15-25份续断，10-15份五加皮，15-25份红花，10-15份芍药，15-30份生姜。
2.一种如权利要求1所述的用于缓解肌肉紧张的玫瑰中药组合物的制备方法，其特征在于，所述制备方法如下：
将玫瑰花，粉防己，独活，当归，续断，五加皮，红花，芍药及生姜混匀，加蒸馏水2L，80℃煎熬半小时，重复三次，合并三次水煎液并浓缩制备成膏状，即得所述玫瑰中药组合物。
3.如权利要求1所述的用于缓解肌肉紧张的玫瑰中药组合物在制备用于缓解肌肉紧张的药物中的应用。
4.如权利要求3所述的应用，其特征在于，所述肌肉为背部、颈肩部、手腕部肌肉。
5.如权利要求1所述的玫瑰中药组合物在制备缓解肌肉过度疲劳的药物中的应用。
6.如权利要求5所述的应用，其特征在于，所述玫瑰中药组合物作为药效成分的药物制剂为霜剂、乳剂、膏剂、粉剂、洗剂、凝胶剂、气雾剂、涂膜剂、酊剂和醑剂。
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