CN105722843B - Scheme for providing the smooth sense of tooth - Google Patents
Scheme for providing the smooth sense of tooth Download PDFInfo
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- CN105722843B CN105722843B CN201380080985.7A CN201380080985A CN105722843B CN 105722843 B CN105722843 B CN 105722843B CN 201380080985 A CN201380080985 A CN 201380080985A CN 105722843 B CN105722843 B CN 105722843B
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- chamber
- phosphate
- sodium phosphate
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- calcium
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/556—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/884—Sequential application
Abstract
The present invention provides a kind of methods of processing dental surface to provide tooth smooth sense advantageous effect, the described method comprises the following steps：(a) dental surface is made to be contacted with the first chamber comprising water-insoluble calcium phosphate；And then (b) makes the dental surface be contacted with comprising organic phosphatic second chamber.
Description
Technical field
The present invention relates to a kind of methods of processing dental surface, and this method includes handling dental surface simultaneously with first chamber
And dental surface then is handled with second chamber, to provide tooth smooth sense.
Background technology
Consumer's routine use oral care product such as toothpaste and mouthwash as their oral care hygiene regimens one
Part.Oral care product is typically formulated to provide treatment advantageous effect and beauty hygiene benefits.Treat advantageous effect packet
Include the prevention of dental caries, gingivitis prevents and allergy control.Beauty benefits include the formation for controlling dental plaque and calculus dentalis, remove simultaneously
And prophylaxis of teeth coloring, tooth whitening, breath freshening and the overall of mouth feel impression improve, feature is mouthfeel U.S. extensively
It sees.Smooth dental surface or tooth smooth feeling is typically considered thoroughly cleaning and effectively delivers the important of these advantageous effects
Signal.
Abrasive material such as silica and calcium carbonate are widely used in toothpaste to remove teeth stains and tooth of polishing, to smooth
Dental surface simultaneously provides tooth smooth feeling.However, abrasive material can cause enamel abrasiveness to be damaged the abrasion of dental surface.It is such
Abrasiveness damage includes enamel loss (such as scratch, minute fissure etc.) and enamel thinning, can make dental surface roughening simultaneously
So that undesirable bacterium is easier to deposit and invade in tooth and therefore cause the destruction of enamel.On the other hand, in cleaning tooth
After tooth in several minutes, teeth stains fixed film tooth is usually formed in from the glycoprotein of saliva by selective binding
On the surface of enamel.After thin coating is adhered to enamel, tooth smooth feeling can reduce rapidly.
Accordingly, there exist solve the problems, such as this needs.Smooth dental surface is needed to be damaged to enamel without abrasiveness.I.e.
Make to be also required to repair dental surface smoothness after enamel loss or thinning.Finally, it needs to provide lasting put down for dental surface
Sliding effect.
Invention content
The present invention one or more of attempts to solve these problems.In one aspect, the present invention provides a kind of processing tooth
The method of tooth surface, this approach includes the following steps：
(a) dental surface is made to be contacted with the first chamber comprising water-insoluble calcium phosphate, wherein the water is insoluble
Property calcium phosphate have 1:1 to 10:1 calcium and the molar ratio of phosphorus；And then
(b) dental surface is made to be contacted with second chamber, wherein the second chamber includes having with following formula
Machine phosphate：
Wherein R is the alkyl for including 4 to 22 carbon atoms；X and Y is each independently the alkylene for including 2 to 4 carbon atoms
Base；A and b is each independently selected from 0 to 20 integer, and wherein a+b is in the range of 0 to 20；Z1And Z2It is each independently selected from
Hydrogen, the alkyl and counter ion counterionsl gegenions for preferably containing one or more ether moieties for including 1 to 26 carbon, precondition is Z1
And Z2At least one of be hydrogen or counter ion counterionsl gegenions.
On the other hand, the present invention provides a kind of oral care kits, and the oral care kits include：
(a) the first product containing first chamber, wherein the first chamber include by weight 0.01% to
99% water-insoluble calcium phosphate, the water-insoluble calcium phosphate have 1:1 to 10:1 calcium and the molar ratio of phosphorus；
(b) the second product containing second chamber, wherein second product be with 6 to 8 pH and 100cps extremely
The mouthwash of the viscosity of 5000cps, and the wherein described second chamber include by weight 0.01% to 99% it is as above calmly
The organic phosphate of justice；With
(c) specification, the specification instruction user contact dental surface using first product first, immediately after
The dental surface is contacted using second product.
On the other hand, present invention offer includes the oral care product of the first container and second container, wherein described
The first container includes first chamber, and the first chamber includes by weight 0.01% to 99% with 1:1 to 10:1
Calcium and phosphorus molar ratio water-insoluble calcium phosphate, and the second container includes second chamber, second combination
Object includes by weight 0.01% to 99% organic phosphate as defined above；And the wherein described product optionally includes
Bright book, the specification instruction user distribute first chamber before distributing second chamber.
One aspect of the present invention usually provides calcium source being applied on dental surface applies specific organic phosphate later
Sequence application system.It is without being bound by theory, it is believed that small in tooth structure for sealing using the first step of calcium source
Crack or gap, and it is believed that be used to calcium being sealed in tooth structure using the second step of specific organic phosphate.Pass through
The sequence application system is smooth by potentially providing new crystal growth, reparation dental surface in enamel loss or thinning area
Degree and/or structure uniform cap layer are so that dental surface smoothness persistently delivers discernable and significant change for dental surface
It is kind.
For those skilled in the art, by the following detailed description, these and other feature of the invention,
Aspect and advantage will become obvious.
Description of the drawings
Claims of the present invention is especially defined and is distinctly claimed although being provided after specification, according to
Letter is better understood the present invention by the following drawings explanation.In the drawings,
Fig. 1 (a) to Fig. 1 (e) shows when handling dental surface, to consume by band when specific embodiment according to the present invention
Dissipate the performance evaluation that the quartz crystal microbalance of monitoring (QCM-D) carries out dental surface.
Fig. 2 (a) to Fig. 2 (d) shows specific embodiment according to the present invention, before processing, with after lemon acid etching, first
Micro- (SPM) image of scanning probe of dental surface after processing step and after second processing step.
Fig. 3 (a) to Fig. 3 (d) shows according to comparing embodiment, before processing, with after lemon acid etching, the first processing step
Afterwards with micro- (SPM) image of the scanning probe of the dental surface after second processing step.
Fig. 4 (a) to Fig. 4 (c) shows according to another comparison embodiment, before processing, with after lemon acid etching, Yi Jiyi
Micro- (SPM) image of scanning probe of step treated dental surface.
Fig. 5 show after specific embodiment according to the present invention processing and according to embodiment processing is compared after, about
Tooth smooth feeling with 3 hours time test result figure.
Specific implementation mode
" oral cavity composition " and " oral care composition " refers to a kind of product, the production used interchangeably herein
Product are not deliberately swallowed the Formulations for systemic administration for particular therapeutic agent instead of during generally use, retain foot in the oral cavity
The enough long time, to contact dental surface and/or oral cavity tissue for local administration.
Unless otherwise specified, as used herein, term " dentifrice " includes for cleaning the paste of tooth by toothbrush, coagulating
Glue, liquid, powder or tablet.Dentrifice composition can be single-phase composite, or can be that two or more are individually clean
The combination of tooth agent composition.
As used herein, term " water-insoluble " means to have solubility in lower water or cannot be dissolved completely in water
In.Specifically, water-insoluble materials are intended to indicate that the object for having at 20 DEG C and being less than the solubility that 1g/l is especially less than 1mg/l
Matter.
As used herein, term " water solubility " means to have solubility in higher water or can completely dissolve in water.
Specifically, water-soluble substances are intended to indicate that the substance at 20 DEG C with the solubility for being especially not less than 10g/l not less than 1g/l.
As used herein, term " granularity " refers to the granularity based on volume measured by laser diffraction method.Laser spreads out
The angle change of scattered light intensity when passing through the particulate samples of dispersion by measuring laser beam is penetrated to measure size distribution.Larger grain
The scattering light of son is smaller relative to the angle of laser beam, and the scattering light of smaller particless is larger relative to the angle of laser beam.
Then, the granularity for resulting in scatter pattern is calculated using the Mie theory analysis angle scattering strength data of light scattering.Granularity
It is reported as equi-volume sphere diameter.Term " average grain diameter " and " average particle size " are used interchangeably herein, and it refers to base
In the average value for the size distribution that logarithmic scale calculates.
Term " alkyl ", " hydrocarbyl substituent " and " hydrocarbyl group " used interchangeably herein, and its refer to have it is straight
It is connected to the carbon atom of the rest part of molecule and the mainly monoradical with hydrocarbon property in succession.Such monoradical can be classified as
The combination (such as alkaryl and aromatic alkyl group) of aliphatic group, cyclic group or aliphatic group and cyclic group.Term " fat
Race's group " means saturated or unsaturated, linear chain or branched chain hydrocarbyl group.The term is for covering such as alkyl, alkenyl and alkynes
Base group.Term " alkyl group " means saturation, linear chain or branched chain hydrocarbyl group comprising such as methyl, ethyl, isopropyl
Base, tertiary butyl, heptyl, dodecyl, octadecyl, amyl, 2- ethylhexyls etc..Term " alkenyl group " means there are one tools
Or undersaturated, linear chain or branched chain the hydrocarbyl group of multiple carbon-to-carbon double bonds, such as vinyl groups.Term " alkynyl group " is anticipated
Referring to has undersaturated, linear chain or branched chain the hydrocarbyl group of one or more carbon-carbon triple bonds.Term " cyclic group " means to classify
For the closed-chain hydrocarbon group of alicyclic group, aromatic group or heterocyclic group.Term " alicyclic group " means that property is similar to aliphatic group
Property cyclic hydrocarbon group.Term " aromatic group " or " aryl group " mean single or multiple core aromatic hydrocarbon group.
As mentioned in this article, term " viscosity " is measured using the Brookfield viscometer with cone and plate attachment.For 0-
Viscosity within the scope of 16000cps uses the Brookfield DV-II viscosimeters with S02 plates.Reading is read at 2.5rpm
Before, 500ml composition samples is made to be balanced three minutes at 25 DEG C.For viscous more than 16000cps and at most 33000cps
Degree, uses the Brookfield DV-I viscosimeters with S02 plates.Before reading reading at 0.3rpm, make 500ml compositions
Sample balances 1 minute at 25 DEG C.
As used herein, " tooth " of term " tooth " or plural form refers to nature tooth and artificial teeth or vacation
Tooth.
Can be used for this paper active material and other ingredients can according to their beauty and/or treatment advantageous effect or they
It is assumed that effect or operational mode classify or describe.It should be appreciated, however, that in some cases, activity for use in the present invention
Substance and other ingredients can provide more than one beauty and/or treatment advantageous effect, or pass through more than one binding mode
It works or runs.Therefore, the classification of this paper for convenience only, and is not intended to ingredient being limited in listed refer in particular to
In the one or more application gone out.
When as used herein, in for claim, article "one" and "an" are understood to mean a kind of or more
Claimed or according to claims the substance of kind.
As used herein, term "comprising", " comprising ", " containing ", " having " meaning be non-limiting, you can be added
Other steps of final result and other ingredients are not influenced.Terms above cover term " by ... form " and " substantially
By ... form ".
As used herein, word " preferred ", " preferably " and their variant refer to being capable of providing in certain circumstances
Embodiment of the present invention of specific advantageous effect.However, other embodiments are alternatively under identical or other environment
Preferably.In addition, the statement of one or more preferred embodiments is not offered as other embodiments and is disabled, and not
It is intended to exclude other embodiments from the scope of the present invention.
Sequence application system
According to the present invention, the sequence application system for handling dental surface is provided.
In first step (a), dental surface is contacted with the first chamber comprising water-insoluble calcium phosphate, wherein described
Water-insoluble calcium phosphate has 1:1 to 10:1 calcium and the molar ratio of phosphorus.The calcium phosphate granules of water-insoluble can be deposited into small
In crack and gap, the source to provide calcium ion and phosphate anion to supplement mineral to enamel.
In second step (b), dental surface further with second group comprising organic phosphate as defined above
Close object contact.Organic phosphate can form protective layer in dental surface, so that calcium ion and phosphate anion are sealed to tooth
In structure.
In a specific embodiment, after contact procedure (a) in 30 minutes, in 15 clocks, in 5 minutes or immediately
Start contact procedure (b).It is preferred that there is no dental procedure steps between two parties between step (a) and step (b).
Contact procedure can be by realizing selected from following any oral care hygiene regimens：Such as brushing, dental floss tooth-cleaning,
Flushing, smearing, attachment and combination thereof.Therefore, first chamber and second chamber can be conducive to oral care
The various forms of sanitation programme.Such form includes but not limited to toothpaste, the tooth for directly applying or being attached to dental surface
Powder, gutta-percha, dental floss, mouthwash, chewable tablets, chewing gum or item or film.In a specific embodiment, first chamber is
Dentifrice composition, and second chamber is mouthwash.In another specific embodiment, first chamber and second group
It closes object and is each independently mouthwash.
Duration of contact depends on concrete scheme and concrete composition form.For example, can be carried out 1 minute with toothpaste brushing
It to 5 minutes, can be carried out 5 seconds to 2 minutes with mouthwash flushing, and 5 minutes to 60 minutes can be carried out with item or film smearing, preferably
20 minutes to 40 minutes.
In a specific embodiment, contact procedure (a) is with (b) each independently with contact in 5 seconds to 5 minutes
Duration；And immediately start contact procedure (b) after contact procedure (a).
In a specific embodiment, connect by brushing dental surface with the toothpaste comprising first chamber to realize
Step (a) is touched, then realizes contact procedure (b) immediately by rinsing dental surface with the mouthwash comprising second chamber.
In another specific embodiment, by rinsing dental surface with the first mouthwash comprising first chamber
It realizes contact procedure (a), is then realized immediately by rinsing dental surface with second mouthwash comprising second chamber
Contact procedure (b).
First chamber
Dental surface is constantly subjected to the loss and gain of minerals.The chemical composition that the process passes through saliva and extracellular fluid
Locally to keep balancing.It can be sent out by the abrasion of acid food and beverage, germ attack and tooth initiation of excessively brushing teeth or mill
The destruction of odontiasis tooth surface integrality.These processes lead to rough surface with exposed dental surface demineraliting.Therefore, root
According to the present invention, first chamber provides the source of calcium ion and phosphate anion, by the minute fissure for depositing to tooth structure
With come in gap or on dental surface to enamel supplement mineral.
In a specific embodiment, first chamber includes water-insoluble calcium phosphate, wherein the water-insoluble
Calcium phosphate has 1:1 to 10:1 calcium and the molar ratio of phosphorus.
Calcium phosphate is the main mine substance being present in tooth.Tooth enamel is made of 90 nearly percent hydroxyapatite,
It is known as the calcium phosphate mineral of bone mineral.Such as being used for the water-insoluble calcium phosphate of the present invention can discharge in physiological conditions
A small amount of calcium ion and phosphate anion with delivering, to promote the mineral of tooth enamel to supplement.
It has been found that the specific molar ratio range of calcium and phosphorus is important the mineral supplement of dental health and tooth enamel.It crosses
The high possibly tartar that can not be effectively inhibited in the saprodontia and/or tooth of corona of calcium and phosphorus ratio, and too low calcium and phosphorus ratio
Rate possibly can not effectively inhibit the saprodontia near gum and/or can increase inflammatory tendency such as pyorrhea and gingivitis.At one
In specific embodiment, water-insoluble calcium phosphate has 1:1 to 5:1 or 1:1 to 3:1 or 1.5:1 to 2.5:1 or 1.3:1
To 2:1 calcium and the molar ratio of phosphorus.
Suitable water-insoluble calcium phosphate for use in the present invention includes but not limited to apatite, phosphoric acid halogen calcium, di(2-ethylhexyl)phosphate
Calcium, tricalcium phosphate, calcium octahate phosphate and their mixture.In one embodiment, apatite is selected from：Hydroxyapatite
(Ca10(PO4)6(OH)2), fluor-apatite (Ca10(PO4)6F2), chlorapatite (Ca10(PO4)6Cl2), bromine apatite (Ca10
(PO4)6Br2) and their mixture.
Water-insoluble calcium phosphate can be any solid form, such as the agglomeration of particle substantially spherical in shape, smaller particle
Object, rod-shpaed particle, elongated piece, fibrous particle or their mixture.
Water-insoluble calcium phosphate can be reality of any size without damaging the present invention that can be deposited on dental surface
Matter.In a specific embodiment, water-insoluble calcium phosphate has 0.01 micron, 0.5 micron, 1 micron, 2 microns or 4 microns
To 5 microns, 8 microns, 10 microns, 15 microns or 20 microns of granularity.
According to the present invention, the geometry and size of water-insoluble calcium phosphate granules can be optimized, so as to by tooth
Various minute fissures and gap on surface account for.
Water-insoluble calcium phosphate by based on the weight of first chamber 0.01%, 0.05%, 0.1%, 0.5%, 1% or
2% to 3%, 5%, 10%, 20%, 50% or 99% amount exists.In a specific embodiment, first chamber packet
Containing by weight 0.1% to 20% apatite.In another specific embodiment, first chamber includes by weight
1% to 5% hydroxyapatite.The amount of the insoluble calcium phosphate of adjustable water, to provide desired technology and sense organ advantageous effect,
Reduce any side effect simultaneously.In certain medical treatment or clinical case, when side effect is inessential, the amount of water-insoluble calcium phosphate
It can be up to 99% based on the weight of first chamber.
The pH of first chamber can be in the range of about 6,7 or 8 to 9,10 or 11.PH can pass through the appropriate flat of calcium phosphate source
Weighing apparatus adds alkaline agent or acidizer to realize.It is without being bound by theory, preferably with respect to the pH in alkalinity, the reason is that it is believed that described
PH stablizes water-insoluble calcium phosphate from dissolving.
Second chamber
According to the present invention, second chamber includes specific organic phosphate compound.Organic phosphate compound is to enamel
Surface such as tooth has strong affinity, and combines tendency with sufficient surface, so that surface membrane protein matter desorbs, and keeps
It is attached to enamel surfaces.It is without being bound by theory, it is believed that when being applied according to the present invention, organic phosphate compound is attached to tooth
Tooth, the calcium in phosphate group combination tooth, therefore calcium is prevented to be dissolved in acidic saliva and be lost.Organic phosphate can also sink
Product prevents the protectiveness surface coating that tooth is in direct contact with aggressivity acid or other harmful substances matter.
Particularly, second chamber includes the organic phosphate with following formula：
Wherein R is the alkyl for including 4 to 22 carbon atoms；X and Y is each independently the alkylene for including 2 to 4 carbon atoms
Base；A and b is each independently selected from 0 to 20 integer, and a+b is in the range of 0 to 20；Z1And Z2It is each independently selected from
Hydrogen, the alkyl and counter ion counterionsl gegenions for preferably containing one or more ether moieties for including 1 to 26 carbon, precondition is Z1
And Z2At least one of be hydrogen or counter ion counterionsl gegenions.
The example that can be used for the hydrocarbyl group of this paper includes but not limited to；(1) hydrocarbon substituent, i.e., aliphatic series (such as alkyl or
Alkenyl), alicyclic (such as naphthenic base, cycloalkenyl group) substituent group and aromatics-, aliphatic series-and alicyclic-substitution aromatic substituent,
And cyclic substituents and its equivalent, wherein the ring is formed by another part of molecule (for example, two substituent groups are together
Form alicyclic group)；(2) hydrocarbon substituent replaced, that is, include the substituent group of non-alkyl, the non-alkyl is on described herein
Do not change hereinafter main hydrocarbon substituent (such as halogen (especially chlorine and fluorine), hydroxyl, alkoxy, sulfydryl, alkyl thiol,
Nitro, nitroso and sulphur oxygroup) and its equivalent；(3) miscellaneous-substituent group, i.e., in context described herein, as substituent group master
Include non-carbon and its equivalent in chain when will be with hydrocarbon property in the ring being made of carbon atom or other means.Hetero atom packet
Sulphur, oxygen, nitrogen are included, and covers substituent group such as pyridyl group, furyl, thienyl and imidazole radicals.In a specific embodiment party
In case, in hydrocarbyl group, every ten carbon atoms exist no more than two, a preferably more than substituents.Another
In a specific embodiment, substituents are not present in hydrocarbyl group.
It is believed that the presence of hydrocarbyl group assigns compound hydrophobic degree so that organic phosphate can on tooth surfaces effectively
Form hydrophobic layer.Such hydrophobic layer can make enamel from aggressivity acid attack and grime, and provide long-acting good refreshing
Sliding sense.
Some examples of organic phosphate include but not limited to alkylphosphonic and alkyl (poly-) alkoxy phosphate, such as
Bay based phosphates (trade name MAP 230K and MAP 230T, can be commercially available from Croda (Snaith, UK))；PPG5 spermaceti
- 10 phosphate of steareth (Crodaphos SG, can be commercially available from Croda (Snaith, UK))；Lauryl is poly-
(trade name MAP L210, can be commercially available from Rhodia (La D é fense, France) for -1 phosphate of ethylene oxide ether；Phosten
HLP-1, can be commercially available from Nikkol Chemical (Tokyo, Japan)；Or Sunmaep L, it can be from Sunjin
Chemical (Korea) is commercially available)；(trade name MAP L130, can be from Rhodia for -3 phosphate of polyoxyethylene lauryl ether
(La D é fense, France) is commercially available；Foamphos L-3, can be commercially available from Alzo (NJ, U.S.)；Or
Emphiphos DF1326, can be commercially available from Huntsman Chemical (Texas, U.S.))；Polyoxyethylene lauryl ether-
9 phosphate (trade name Foamphos L-9, can be commercially available from Alzo (NJ, U.S.))；- 4 phosphorus of three polyoxyethylene lauryl ethers
Hydrochlorate (trade name Hostaphat KL 340D, can be commercially available from Clariant (Muttenz, Switzerland))；Or
TLP-4, can be commercially available from Nikkol Chemical (Tokyo, Japan))；9 phosphate (trade names of C12-18PEG
CrafolAP261, can be commercially available from Cognis (Ludwigshafen, Germany))；- 10 phosphorus of dilauryl polyoxyethylene ether
Sour sodium (trade name DLP-10, can be commercially available from Nikkol Chemical (Tokyo, Japan)).
In particular, preferred organic phosphate is to include alkoxy base, the alkoxy base (O- especially repeated
X)a(O-Y)bThose of, especially include one or more ethyoxyls, propoxyl group, isopropoxy, butoxy radicals or their group
Those of close.It is believed that alkoxy base presence increase compound solubility and equilibrium compound it is amphipathic so that it is hydrophilic
Acid phosphate head " can adhere to " to dental surface (giving its charge), while hydrophobicity hydrocarbon tail extends to Long carbon chain.Separately
On the one hand, the presence of alkoxy base can help to substance and be diffused out from dental surface.
In addition suitable organic phosphate may include alkyl monoglyceride phosphate, alkyl sorbitan alcohol phosphate, alkane
Ylmethyl glucoside phosphate, alkyl sucrose phosphate, glucan phosphate, poly glucoside phosphate, alkyl polyglucoside phosphorus
Hydrochlorate, poly-glycerine phosphate, alkyl poly-glycerine phosphate, polyethers phosphate and alkoxylated polyol phosphate.Some tools
Body example may include polyethylene glycol (PEG) phosphate, polypropylene glycol (PPG) phosphate, alkyl PPG phosphate, PEG/PPG phosphoric acid
Salt, alkyl PEG/PPG phosphate, PEG/PPG/PEG phosphate, dipropylene glycol phosphate, PEG glycerophosphates, polybutadiene
Alcohol (PBG) phosphate, PEG cyclodextrin phosphate, PEG sorbitans phosphate, PEG alkyl sorbitan alcohol phosphoric acid
Salt, PEG methyl glucosamines phosphate and combination thereof.
Organic phosphate can provide desired surface conditioning effects, including：1) membrane proteins of undesirable absorption
Effectively desorption especially forms with teeth stains adherency, calculus dentalis and undesirable microbe species adsorbs relevant desorption；With
And 2) surface conditioning effects and the control formed to film are made to be maintained for a long time after using product.The composition of the present invention
By combining calcium minerals (such as hydroxyapatite) in tooth to provide protectiveness surface coating.The protectiveness surface coating is logical
It crosses and changes surface hydrophilicity and hydrophobicity and improve the resistance of the erosion to acid to provide improved tooth surface characteristics.
The amount of organic phosphate is available to having for the good smooth sense of one section of expected time of protective layer in second chamber
Effect amount.Preferably, the protection continues at least one hour after using the composition.The organic phosphate can be with effective quantity
In the presence of to provide at least 10 degree of increase of water contact angle on the surface, and the hydrophobicity is kept at least 5 minutes
Time.In a specific embodiment, the organic phosphate by based on the weight of second chamber 0.01%,
0.02%, the amount in the range of 0.03%, 0.05%, 0.07% or 0.1% to 0.5%, 1%, 5%, 10%, 50% or 99%
In the presence of.The amount of adjustable organic phosphate, to provide desired technology and sense organ advantageous effect, while reducing any side effect,
Organic phosphate compound can have for example undesirable bitter taste or soapy flavor under the side effect.In certain medical treatment or clinic
In case, when being not enough to consider undesirable bitter taste or soapy flavor, the amount of organic phosphate is based on the weight of second chamber
It can be up to 99%.
In a specific embodiment, organic phosphate is by defined below：R is the alkane for including 8 to 16 carbon atoms
Base；A+b is 1 to 10；And Z1And Z2It is each independently selected from hydrogen and alkali metal counter ion counterionsl gegenions.Preferably, Z1And Z2In at least
One is the alkali metal counter ion counterionsl gegenions selected from sodium ion and potassium ion；And the wherein described second chamber includes by weight
0.01% to 10% organic phosphate.
Specifically, the organic phosphate can be selected from：- 1 sodium phosphate of polyoxyethylene lauryl ether, lauryl polyoxyethylene
- 2 sodium phosphate of ether, -3 sodium phosphate of polyoxyethylene lauryl ether, -4 sodium phosphate of polyoxyethylene lauryl ether, lauryl polyoxyethylene
- 1 potassium phosphate of ether, -9 sodium phosphate of polyoxyethylene lauryl ether, -2 sodium phosphate of myristyl polyoxyethylene ether, alkyl polyoxyethylene
- 1 sodium phosphate of ether and their mixture.
In a specific embodiment, second chamber include by weight 0.01% or 0.05% to 5% or
10% -1 sodium phosphate of polyoxyethylene lauryl ether.
The pH of second chamber can be in the range of 5,6 or 6.5 to 7.5,8 or 10.The pH of second chamber do not answer it is too low,
The reason is that organic phosphate may hydrolyze in strong acidic environment.
Optional components
The first chamber and second chamber of the present invention can include a variety of oral cavity compositions of can be used for each independently
Optional conventional constituents add advantageous effect to increase the advantageous effect mentioned by this paper or provide.Such optional components include but
It is not limited to fluoride ion source, thickener, wetting agent, surfactant, antiseptic, colorant, flavouring agent and some is other
Conventional constituents.
The fluoride ion source for being capable of providing free fluorine ion is also referred to as water soluble fluoridized material resource, can be by increasing to fluorine
Change the part supersaturation of calcium phosphate deposition and mineral supplement is promoted to accelerate.Fluoride absorbs or fluorination refers to using fluoride reagents
Local treatment and cause fluoride to collect in dentine.Supplement mineral and the tooth of fluoride intake enhancing show excellent pair
The resistance of sour demineraliting, to help to make the smooth effect of dental surface lasting.Water soluble fluoridized material resource can be selected from：Fluorination
Sodium, stannous fluoride, sodium monofluorophosphate, amine fluoride and their mixture.In a specific embodiment, described
Two compositions include be capable of providing 50ppm, 500ppm, 1000ppm or 1500ppm to 2000ppm, 2500ppm, 3000ppm or
The water soluble fluoridized material resource of the free fluoride ion of 3500ppm.In another specific embodiment, the second chamber packet
Sodium fluoride containing by weight 0.005%, 0.01% or 0.02% to 0.1%, 1% or 5%.In even another specific reality
It applies in scheme, the first chamber includes by weight 1% to 5% hydroxyapatite, and the second chamber packet
Containing by weight 0.05% to 5% -1 sodium phosphate of polyoxyethylene lauryl ether and by weight 0.01% to 1% sodium fluoride.
Thickener (also referred to as thickening agent) is commonly used in increase solution or the viscosity of liquid/solid mixtures.According to this hair
It is bright, thickener can be mixed, the desired consistency of consumer and tooth coating ability are supplied to the viscosity by regulation composition.
The delivery form of root Ju composition, oral care composition of the invention can have 10cps, 50cps, 100cps, 500cps,
800cps, 1200cps or 2000cps to 3000cps, 5000cps, 8000cps, 12000cps, 20000cps, 30000cps or
The range of viscosities of 45000cps.In a specific embodiment, the first chamber has 2000cps to 8000cps
Viscosity.In another specific embodiment, the second chamber has the viscosity of 1200cps to 3000cps.Thickening
Composition tends to provide more longlasting advantageous effect in dental surface.Thickener can also improve the suspension of insoluble composition, with
Stable and uniform composition is provided.When the first chamber comprising water-insoluble calcium phosphate is mouthwash, this point is particularly
Favorably.Preferred thickener is selected from：Carboxy vinyl polymer, carrageenan, xanthans, cellulosic polymer, hydroxy ethyl fiber
Element, carboxymethyl cellulose, ammonium acryloyldime-thyltaurate/vinylpyrrolidone copolymer, polyethylene oxide, acrylic acid
Ester/C10-30 alkyl acrylate cross-linked polymers, polyacrylic acid, cross linked polyacrylate, polycarbophil, alginate, clay,
Glucose, pectin, gelatin and their compositions.Colloidal magnesium aluminum silicate or the silica of subdivision also are used as thickener
A part further to improve texture.Thickener can by 0.01% based on the weight of first chamber or second chamber,
0.1%, the amount of 0.2%, 0.3% or 0.4% to 2%, 5%, 8%, 10% or 20% exists.
Wetting agent such as polyethylene glycol can also be used for improving viscosity and provide smooth sense to Dentrifice composition.It can get
Larger average molecular weight range and the polyethylene glycol with different performances, the performance depend on their mean molecule
Amount.Wetting agent is assigned for avoiding the oral cavity composition especially dentifrice composition in the after-hardening for being exposed to air
Oral area damp.Certain wetting agents can also assign oral cavity composition such as mouthwash and toothpaste desired sweet taste.For the present invention
Suitable humectants include edible polyalcohol such as glycerine, sorbierite, xylitol, butanediol, polyethylene glycol, propylene glycol,
And their mixture.Wetting agent optionally by based on the weight of first chamber or second chamber 1%, 2%, 5% or
8% to 15%, 25%, 50% or 70% amount exists.
Surfactant can be used for for example so that other components of oral care composition are more compatible each other.This provides enhancing
Stability, contribute to by washing come teeth surfaces, and for example with the present invention Dentrifice composition brush the phase
Between stir when foam is provided.Any oral acceptable surfactant can be used, most of is anion, nonionic or two
The surfactant of property.Suitable anion surfactant includes unlimitedly C8-20 alkyl sulfates, C8-20 aliphatic acid
Sulfonated monoglycerides, sarcosinate, taurate etc. water soluble salt.The exemplary example of these and other type includes the moon
The different ethionine sodium of osmanthus base sodium sulphate, coconut monoglyceride sodium sulfonate, sodium lauryl sarcosinate, lauryl, lauryl polyoxy second
Alkene ether carboxylic acid sodium and neopelex.
Suitable nonionic surfactant includes unlimitedly poloxamer, polyoxyethylene sorbitan ester, fat
Fat acid ethoxylate, alkylphenol ethoxylate, tertiary amino oxides, phosphine oxides, dialkyl sulphoxide etc..Suitable both sexes
Surfactant includes unlimitedly having anionic group such as carboxylate radical, sulfate radical, sulfonate radical, phosphate radical or phosphonate radical
The derivative of C8-20 aliphatic secondary amines and tertiary amine.Suitable example is cocoamidopropyl.Surfactant is optionally
Exist by based on the weight of first chamber or second chamber 0.01%, 0.05% or 0.1% to 2%, 5% or 10% amount.
Antiseptic for use in the present invention includes but not limited to water-insoluble non-cationic antimicrobial agent and water-soluble antimicrobial,
Such as quaternary ammonium salt and double two guanidine salts.Triclosan monophosphate is additional water-soluble antimicrobial.In certain preferred embodiments
In, antiseptic is selected from：Halogenation cetyl pyridinium, halogenation domiphen, stannous ion source, zinc ion source, copper ion source and it
Mixture.Antiseptic can by based on the weight of first chamber or second chamber 0.01%, 0.05%, 0.1% or
0.2% to 0.5%, 1.0%, 1.2% or 1.5% amount exists.
The colorant of this paper includes pigment, dyestuff, color lake and the reagent such as pearling agent for assigning specific gloss or reflectivity.
Colorant can realize multiple functions comprising for example provide white or light-colored coating on tooth surfaces, serve as by composition
The indicator in site and/or modifying composition appearance especially color and/or opacity on the dental surface effectively contacted
To increase the attraction to user.Can be used it is any take orally acceptable colorant comprising but be not limited to talcum, mica,
Magnesium carbonate, calcium carbonate, magnesium silicate, aluminium-magnesium silicate, silica, titanium dioxide, zinc oxide, red, yellow, brown and black oxygen
Change iron, ferriferro cyanide ammonium, manganese violet, ultramarine pigment, metatitanic acid mica, bismuth oxychloride etc..
Flavouring agent can be used for for example enhancing the taste of composition.Any oral acceptable natural or synthetic wind can be used
Taste agent comprising but it is not limited to vanillic aldehyde, Salvia japonica, origanum, parsley oil, spearmint oil, cinnamon oil, wintergreen (water
Poplar acid methyl esters), Fructus Piperis peppermint oil, caryophyllus oil, oreodaphene, oleum anisi, eucalyptus oil, citrus oils, fruit oil and essence (including derivative
From those of lemon, orange, bitter orange, grape fruit, apricot, banana, grape, apple, strawberry, cherry, pineapple etc.), beans and nut it is (all
Such as coffee bean, cocoa bean, kola nut, peanut, almond etc.) derived from flavouring agent, absorption and encapsulating flavouring agent etc..Herein
Flavouring agent be also contemplated by that fragrance and/or other sensory effects are provided in mouth includes refrigerant or the ingredient of warm effect.It is such at
It includes menthol, menthyl acetate, menthyl lactate, camphor, eucalyptus oil, eucalyptol, anethole, fourth to divide illustrative
Fragrant phenol, cassia bark, oxanes ketone, α-ionone, 1-ethoxy-2-hydroxy-4-propenyl benzene, thymol, linalool, benzaldehyde, cinnamic acid, N-
P- peppermint -3- the formamides of ethyl -, N, 2,3- trimethyl -2- butanamides, 3- (1- peppermints oxygroup) propyl- 1,2- glycol,
Cinnamic acid glycerine acetal (CGA), menthone glycerol acetal (MGA) etc..
Oral care kits and product
Production the present invention also provides any type of external member and comprising first chamber as described above and second chamber
Product.
In some embodiments, the oral care kits include：
(a) the first product containing first chamber, wherein the first chamber include by weight 0.01% to
99% water-insoluble calcium phosphate, the water-insoluble calcium phosphate have 1:1 to 10:1 calcium and the molar ratio of phosphorus；
(b) the second product containing second chamber, wherein second product be with 6 to 8 pH and 100cps extremely
The mouthwash of the viscosity of 5000cps, and the wherein described second chamber include by weight 0.01% to 99% it is as above calmly
The organic phosphate of justice；With
(c) specification, instruction user contact dental surface using first product first, use immediately after described
Second product contacts the dental surface.
In some embodiments, the external member further comprises applying first chamber and/or second to dental surface
The application device of composition, such as composition is made to be deposited on the injector type application device of dental surface or for applying composition
Semicircle flute profile application device for dental surface.External member also optionally includes being applied to dental surface about by composition
The specification of the purposes of application device.
In a specific embodiment, first product and second product can be physically isolated, respectively
It independently is any appropriate form, such as liquid form or dry powder.When the composition of offer is dry powder, the composition can lead to
It crosses and adds suitable solvent (also being included in external member) and be reconstructed.In some embodiments, when providing liquid form,
The composition can be concentration or be instant.
In a specific embodiment, first product and second product are each independently mouthwash.
In some embodiments, the present invention is intended to provide the single oral care production including the first container and second container
Product, wherein the first container includes first chamber, which includes by weight 0.01% to 99% to have
1:1 to 10:The water-insoluble calcium phosphate of 1 calcium and the molar ratio of phosphorus, and the second container includes second chamber, and this
Two compositions include by weight 0.01% to 99% organic phosphate as defined above.The product optionally includes saying
Bright book, instruction user distribute first chamber before distributing second chamber.
In a specific embodiment, single oral care product further comprises that specification, instruction user exist
Distribution first chamber contacts dental surface first from the first container when using every time, and the is then distributed from second container
Two compositions contact dental surface.
In another specific embodiment, single oral care product further comprises pumping, in each application processing
When scheme, the pump pumps first chamber when first activates from the first container, and when second activates from second container
Pump second chamber.
Embodiment：
Following embodiment further describes and demonstrates the embodiment in the scope of the invention.These embodiments given are only
It is merely illustrative, is not to be construed as limitation of the present invention, because the case where not departing from the spirit and scope of the invention
Under can carry out many modifications.
First chamber
Table 1 shows the embodiment of the first chamber according to the present invention of mouthwash form.Preparation method is as follows：To first
Glycerine and polymer are added in mixing vessel, mixing is up to fine dispersion is to obtain pre-composition 1；It is added into the second mixing vessel
Water (the 10% of total amount), flavouring agent ＆ sensory agents, hydroxyapatite, sweetener, liquid preservative, surfactant and colorant ＆
Beautiful agent (aesthetics), mixing is up to fine dispersion and uniformly to obtain pre-composition 2；Water is added into main mixing channel
(the 90% of total amount), solid preservative and thickener, mixing is until uniformly to obtain main mixture；Pre-composition 1 is added to master
In mixture, mixing is until fine dispersion；The 25% of sodium hydroxide total amount is added in main mixture (if applicable),
Mixing is until uniformly；Pre-composition 2 is added in main mixture, mixing until fine dispersion and uniformly；And addition is remaining
Sodium hydroxide until pH be 7.
Table 1
1)Hydroxyapatite is supplied by Bio-Rad (Hercules, CA, USA).
2)Hydroxyapatite is supplied by Fluidinova (Moreira da Maia, Portugal).
As mouthwash, suitable viscosity will be such that hydroxyapatite is equably suspended in composition and advantageously combined object
Contact appropriate is simultaneously held in dental surface.First chamber A1 to A8 be respectively provided with 2580cps, 7690cps, 5072cps,
The viscosity of 2600cps, 29433cps, 132cps, 220cps and 116cps.
Table 2 shows the embodiment of the first chamber according to the present invention of toothpaste form.Preparation method is as follows：By water, wet
Profit agent, part flavouring agent, colorant, buffer solution and activating agent are added in 35 DEG C of main mixing channel, are sufficiently mixed and are ensured institute
Some ingredients have dissolved or fully dispersed；Thickener and sweetener are added in main mixing channel, mix and are homogenized until fully
Disperse and uniform；Abrasive material is added, mix and is homogenized until fully dispersed and uniform；Degassing；By surfactant solution, remain
The flavouring agent of remaining part point is added in main mixing channel, is mixed and is homogenized until uniformly；Degassing；It pumps out and cools down batch of material to being less than
40℃。
Table 2
1) hydroxyapatite is supplied by Bio-Rad (Hercules, CA, USA).
2) hydroxyapatite is supplied by Fluidinova (Moreira da Maia, Portugal).
Second chamber
Table 3 shows the embodiment of the second chamber according to the present invention of mouthwash form.Preparation method and mouthwash shape
The preparation method of the first chamber of formula is identical, unlike hydroxyapatite is not added in pre-composition 2 and by sodium fluoride and
Organic phosphate adds together with water (the 90% of total amount), solid preservative and thickener to obtain main mixture.
Table 3
3) -1 phosphate of polyoxyethylene lauryl ether supplied by Rhodia, through preneutralization
4) -9 phosphate of polyoxyethylene lauryl ether supplied by Alzo, is neutralized with NaOH
Second chamber B3 to B7 is respectively provided with the viscous of 3072cps, 1376cps, 216.5cps, 1408cps and 2616cps
Degree.Do not measure B1 and B2.
Table 4 shows the embodiment of the second chamber according to the present invention of non-ground gutta-percha form.Preparation method is as follows：It will
Mineral oil/vaseline/Versagel, wetting agent, part flavouring agent and colorant are added in 35 DEG C of main mixing channel, fully mixed
Merging ensures that all ingredients have dissolved or fully dispersed；Organic phosphate and sweetener are added in main mixing channel, mixed
And it is homogenized until fully dispersed and uniform；Degassing；The flavouring agent of surfactant solution, remainder is added to main mixing
In slot, mixes and be homogenized until uniformly；Degassing；It pumps out and cools down batch of material to less than 40 DEG C.
Table 4
| Ingredient | B8 | B9 | B10 | B11 | B12 |
| MAP L-1305) | 13.330 | - | - | - | - |
| Foamphos L-36) | - | 8.000 | - | - | - |
| MAP 230K7) | - | - | 10.000 | - | - |
| DLP-108) | - | - | - | 5.000 | - |
| Crodaphos SG9) | - | - | - | - | 2.000 |
| Glycerine | 20.000 | 13.000 | 22.000 | 35.000 | - |
| Flavouring agent | 2.000 | 2.000 | 2.000 | 2.000 | 1.000 |
| Saccharin | 0.500 | 0.500 | 0.500 | 0.500 | 2.000 |
| Polyethylene oxide | 2.000 | 2.000 | 2.000 | 2.000 | - |
| Carpobol 956 | 0.500 | 0.500 | 0.500 | 0.500 | - |
| Mineral oil | - | - | - | 55.000 | - |
| Vaseline | 61.670 | 64.000 | 63.000 | - | - |
| Versagel | - | - | - | - | 95.000 |
| It amounts to | 100 | 100 | 100 | 100 | 100 |
5) -3 phosphate of polyoxyethylene lauryl ether supplied by Rhodia, is neutralized with NaOH
6) -3 phosphate of polyoxyethylene lauryl ether supplied by Alzo, is neutralized with NaOH
7) C12/13 potassium phosphates are supplied by Croda
8) -10 sodium phosphate of dilauryl polyoxyethylene ether supplied by Nikkol Chemical
9) -10 phosphate of PPG5 cetearyls polyoxyethylene ether supplied by Croda, is neutralized with NaOH
Sequence application system
It can be in a kind of and second chamber as shown in Table 3 and Table 4 that will be in first chamber as shown in Table 1 and Table 2
One kind be attached in sequence oral administration processing scheme.The embodiment of sequence composition according to the present invention is shown in table 5.
Table 5
The composition of mouthwash form is applied by aspirating the mouthwash of 20ml in mouth and containing spuing after coughing 30 seconds
For dental surface.In application, it can not be aspirated in mouth when theme composition is too viscous or too thick or when containing coughing, can be used and close
Suitable application device such as swab will be on composition application (such as sprawl or smear) to dental surface.
The composition of toothpaste form is applied to dental surface by being brushed 2 minutes with toothbrush.
By gutta-percha being uniformly administered in denture fixing device and denture fixing device being placed in the combination by gutta-percha form in 10 minutes on tooth
Object is applied to dental surface.
Effect measures
Quartz crystal microbalance (QCM-D) with the monitoring that dissipates
QCM-D is very sensitive mass balance technology, allows while measuring the adsorption dynamics adsorption kinetics and viscoelastic of adsorption layer
Property.
In QCM-D, encourage quartz crystal on its basic resonance frequency by the way that AC voltages are applied to crystal both ends
Oscillation.The material being adsorbed onto on plane of crystal causes resonant frequency to change, proportional to the quality of adsorbed film.
It can measure damping/dissipation of the crystal oscillation for film, enabling measure the viscoplasticity of film.
Δ D=EIt dissipates/2πEStorage
Wherein D is the gross energy stored in the energy divided by crystal that oscillation dissipates every time.
Larger Δ D values show that softer, deformable material attaches to crystal.Rigid material leads to smaller Δ D.
Fig. 1 (a) shows the QCM-D data of the dental surface with the processing of the embodiment of the present invention 1 to 1 (e).
In sequential order test dental surface is handled in accordance with three steps.First step is to rinse tooth with deionized water
Surface.Second step is to rinse dental surface with first chamber A2.Third step is further rinsed with second chamber B6
Dental surface.Three columns of each figure indicate QCM-D test results after each step in Fig. 1 (a) to 1 (e).
It can find out from QCM-D data, before being handled according to the present invention, not form adsorption layer on dental surface.With first
After compositions-treated, show that viscoelastic layer is adsorbed onto on dental surface.After being further processed with second chamber, pass through
Increase quality, density and thickness to strengthen adsorption layer.
Scanning probe microscopy method (SPM)
Scanning probe microscopy method is used to generate the surface topography image of nano-scale resolution.In the art, it monitors
The flexure of the cantilever spring of microfabrication, the reason is that it is in the enterprising line raster scanning in surface considered.Surface roughness analysis
Quantitative measurment is allowed to be modified the shape characteristic of the function of feature as surface.
Fig. 2 (a) to Fig. 2 (d) shows the variation of the enamel surfaces when being handled with the embodiment of the present invention 1.Fig. 2 (a) is shown
Coarse enamel surfaces (compareing) before processing.Fig. 2 (b) shows that enamel surfaces are further coarse by with lemon acid etching
Change.Fig. 2 (c) shows slightly smooth enamel surfaces after with first chamber A2 processing but deposition has some insoluble components
(larger particles).It is believed that hydroxyapatite has deposited on surface.Fig. 1 (d) shows to put down after then using second chamber B6 to handle
Sliding enamel surfaces.
In contrast, Fig. 3 (a) to Fig. 3 (d) is shown with the identical composition with the embodiment of the present invention 1 but with not
With the variation of enamel surfaces when sequential processes.In other words, with after second chamber B6 processing ratio is handled with first chamber A2
Compared with enamel surfaces.Enamel surfaces (compareing) coarse before showing processing Fig. 3 (a).Fig. 3 (b) is shown with lemon acid etching
It is similar to the coarse enamel surfaces of Fig. 2 (b) afterwards.Fig. 3 (d) shows more smoother than Fig. 2 (c) after with second chamber B6 processing
Enamel surfaces.However, after carrying out two-step pretreatment with first chamber A2 after with second chamber B6, glaze that Fig. 3 (d) is shown
Enamel surfaces are coarse shown in matter surface ratio Fig. 2 (d).With in Fig. 2 (d) only compared with the depth of 10nm, in 3 (d) protrusions or recessed
Sunken region can be up to the depth of 20nm.
In addition shooting SPM images are to show with oralPro-Expert dentifrices (on March 18th, 2011 is produced in US)
The variation of enamel surfaces after progress conventional treatment.It is oralPro-Expert dentifrices do not include the as defined herein
One composition or second chamber.Fig. 4 (a) shows the preceding coarse enamel surfaces of processing.Fig. 4 (b) is shown by with lemon acid etching
It carves and further coarse enamel surfaces.Fig. 4 (c) shows the enamel surfaces after dentifrice treatment, almost with the enamel of etching
Surface is equally coarse.It can be seen that dentifrice treatment is difficult to change enamel surfaces smoothness.
In short, SPM data show processing according to the present invention so that dental surface is more smooth.
Naked eyes evaluation group examines (DPP)
The naked eyes evaluation group of tooth smooth feeling examines to be implemented by descriptive group (DPP), and the group is by by upper
10 people for stating average sensory acuity and describing the perceptibility screening of tooth smooth feeling are constituted.Panelist it is trained via
Spectrum (TM) method evaluates the particular community of oral care product, and with, foundation unrelated with individual's preference or preference
The unique ability that attribute evaluates the attribute for evaluating oral care product.In the test, panelist uses production
Product, while for the cleaning mouthfeel ballot (including smooth tooth measures) in 3 hours of its standard, after use instruction in 3 hours and evaluation
Product.Panelist also provides descriptive analysis and additional random comment, proposes any other attribute of sensation.Each category
Property measured under 0-30 scales, the interval of restriction is no longer than 15 minutes.After first hour, panelist drinks
8oz/236.59mL soda (It is decaffeinatedDietWith without coffee
Coffee is because of dietOne of), continue to evaluate.
Inspection institute of the appraisal group related products include：Only first chamber (A2)；Only second chamber (B6)；According to
The sequence application system that B6 is applied after application A2 of the embodiment of the present invention 1；It is applied using the sequence of A2 after application B6
Use system；AndMouthwash (including hydroxyapatite variant, be produced in British on June 11st, 2011).
As shown in figure 5, the sequence application system according to the present invention using using B6 after A2 changes over time offer most
Good tooth smooth feeling.Although can provided just after treatment by comparison using the sequence application system of A2 after application B6
Tooth smooth feeling, but the value of tooth smooth feeling in 10 minutes in declining rapidly after treatment.A2 sequential processes are used after with B6
20 minutes afterwards, the value of tooth smooth feeling those of obtained than sequential processes according to the present invention it is low, and even than only use A2 or
B6 is individually handled and those of acquisition is low.
Mouthwash is the commercial product of packet zinc-containing hydroxyapatite (zinc hydroxyapatite).It can
As can be seen from Figure 5, the evaluation of instant and lasting tooth smooth feeling is far below those of sequential processes according to the present invention acquisition.
Unless otherwise specified, all percentages, ratio and ratio are based on the weight meter of total composition.Unless in addition referring to
Bright, all temperature are with degree Celsius (DEG C) for unit.Unless otherwise specified, all measurements carry out at 25 DEG C.All groups
Divide or composition levels refer to the activity substance content of the component or composition, and does not include that may be present in commercial source
Impurity, such as residual solvent or by-product.
It should be understood that each greatest measure limit provided in the present specification includes each lower numerical limitation, as
Such lower numerical limitation is expressly written herein herein.The each minimum value limit provided in the present specification will include
Each higher numerical limitation, as such higher numerical limitation is expressly written herein herein.It provides in the present specification
Each numberical range is by each narrower numberical range including being contained within the scope of the bigger numerical, such as such narrower number
Value range is equally also expressly written herein herein.
It is to be appreciated that dimension disclosed herein and value, which are not intended to, is strictly limited to cited exact value.On the contrary, unless another
It indicates outside, otherwise each such dimension is intended to indicate that described value and around the functionally equivalent range of the value.For example, open
It is intended to indicate that " about 40mm " for the dimension of " 40mm ".
It is limited unless expressly excluded or in other ways, each document cited herein, including any intersection
Reference or related patents or application and the application are claimed priority to it or any patent application of advantage or patent,
It is incorporated by reference and is incorporated herein accordingly.The reference of any document be not to it relative to any disclosed in this invention or
The approval of the claimed prior art herein, or be not to it individually or with any other one or more
The combination proposition of bibliography, the approval for suggesting or disclosing any such invention.In addition, any of term contains in of the invention
In justice or definition and the file being incorporated by reference when any meaning or definition contradiction of same term, it should obey in this hair
The bright middle meaning for assigning the term or definition.
Although specific embodiments of the present invention have had been illustrated and described, for those skilled in the art
For it is readily apparent that various other changes and modification can be made without departing from the spirit and scope of the present invention.
Therefore, all such changes and the modification covered in appended claims and belonged in the scope of the invention are intended to.
Claims (16)
1. a kind of non-treatment method of processing dental surface, the described method comprises the following steps：
(a) dental surface is made to be contacted with the first chamber comprising water-insoluble calcium phosphate, wherein the water-insoluble phosphorus
Sour calcium has 1:1 to 10:1 calcium and the molar ratio of phosphorus, wherein the water-insoluble calcium phosphate is selected from：Apatite, phosphoric acid halogen calcium,
Dicalcium Phosphate, tricalcium phosphate, calcium octahate phosphate and their mixture；And then
(b) dental surface is made to be contacted with second chamber, wherein the second chamber includes organic phosphate, wherein institute
Organic phosphate is stated to be selected from：- 1 sodium phosphate of polyoxyethylene lauryl ether, -2 sodium phosphate of polyoxyethylene lauryl ether, lauryl polyoxy
- 3 sodium phosphate of vinethene, -4 sodium phosphate of polyoxyethylene lauryl ether, -1 potassium phosphate of polyoxyethylene lauryl ether, lauryl polyoxy second
- 9 sodium phosphate of alkene ether, -2 sodium phosphate of myristyl polyoxyethylene ether, -1 sodium phosphate of alkyl polyoxyethylene ether and their mixing
Object.
2. according to the method described in claim 1, wherein after contact procedure (a) terminates, start contact step in 15 minutes
Suddenly (b).
3. according to the method described in claim 1, the wherein described first chamber includes by weight 0.1% to 20% phosphorus ash
Stone.
4. according to the method described in claim 3, the wherein described first chamber includes by weight 1% to 5% hydroxy-apatite
Stone.
5. according to the method described in claim 1, the wherein described second chamber include by weight 0.01% to 10% it is organic
Phosphate.
6. according to the method described in claim 1, the wherein described second chamber includes by weight 0.05% to 5% lauryl
- 1 sodium phosphate of polyoxyethylene ether.
7. according to the method described in claim 2, the wherein described second chamber also includes water soluble fluoridized material resource.
8. according to the method described in claim 7, the wherein described soluble fluoride source is selected from：Sodium fluoride, stannous fluoride, single fluorine
Sodium phosphate, amine fluoride and their mixture；The wherein described first chamber includes by weight 0.1% to 20% hydroxyl
Apatite；And the wherein described second chamber includes by weight 0.01% to 10% -1 phosphoric acid of polyoxyethylene lauryl ether
Sodium.
9. according to the method described in claim 2, the wherein described first chamber is dentifrice composition, and described second combines
Object is mouthwash.
10. according to the method described in claim 2, the wherein described first chamber and the second chamber are respectively and gargle
Water.
11. according to the method described in claim 2, the wherein described second chamber is mouthwash, extremely with 100cps
The viscosity of 5000cps.
12. according to the method described in claim 2, the wherein described first chamber has 7 to 10 pH.
13. according to the method described in claim 2, the wherein described second chamber has 6 to 8 pH.
14. according to the method described in claim 2, the wherein described contact procedure (a) and (b) have 5 seconds to 5 points each independently
The duration of contact of clock；And after the contact procedure (a) is terminated, the contact procedure (b) is immediately begun to.
15. according to the method for claim 14, wherein the first chamber is the hydroxyl for including by weight 1% to 5%
The mouthwash of apatite, and the second chamber is the polyoxyethylene lauryl ether -1 for including by weight 0.05% to 5%
Sodium phosphate and by weight 0.01% to 1% sodium fluoride mouthwash；And the wherein described second chamber has 6.5 to 7.5
PH and 1000cps to 3000cps viscosity.
16. a kind of oral care kits, the oral care kits include：
(a) the first product containing first chamber, wherein the first chamber includes by weight 0.01% to 99% water
Insoluble calcium phosphate, the water-insoluble calcium phosphate have 1:1 to 10:1 calcium and the molar ratio of phosphorus, wherein the water-insoluble
Calcium phosphate is selected from：Apatite, phosphoric acid halogen calcium, Dicalcium Phosphate, tricalcium phosphate, calcium octahate phosphate and their mixture；
(b) the second product containing second chamber, wherein second product be with 6 to 8 pH and 100cps extremely
The mouthwash of the viscosity of 5000cps, and the wherein described second chamber includes by weight 0.01% to 99% organic phosphoric acid
Salt, wherein the organic phosphate is selected from：- 1 sodium phosphate of polyoxyethylene lauryl ether, -2 sodium phosphate of polyoxyethylene lauryl ether,
- 3 sodium phosphate of polyoxyethylene lauryl ether, -4 sodium phosphate of polyoxyethylene lauryl ether, -1 potassium phosphate of polyoxyethylene lauryl ether, the moon
- 9 sodium phosphate of osmanthus base polyoxyethylene ether, -2 sodium phosphate of myristyl polyoxyethylene ether, -1 sodium phosphate of alkyl polyoxyethylene ether and
Their mixture；With
(c) specification, the specification instruction user contact dental surface using first product first, use immediately after
Second product contacts the dental surface.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/087671 WO2015074241A1 (en) | 2013-11-22 | 2013-11-22 | Regimen for providing smooth tooth feel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105722843A CN105722843A (en) | 2016-06-29 |
| CN105722843B true CN105722843B (en) | 2018-08-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380080985.7A Active CN105722843B (en) | 2013-11-22 | 2013-11-22 | Scheme for providing the smooth sense of tooth |
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| Country | Link |
|---|---|
| EP (1) | EP3071580A1 (en) |
| CN (1) | CN105722843B (en) |
| AU (1) | AU2013406042B2 (en) |
| CA (1) | CA2929053C (en) |
| MX (1) | MX2016006399A (en) |
| WO (1) | WO2015074241A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093058A (en) * | 1992-08-26 | 1994-10-05 | 美国健康基金会牙科协会 | The mineralising fluorination process and the composition of calcified tissue |
| CN102802732A (en) * | 2009-09-11 | 2012-11-28 | 宝洁公司 | Methods and compositions for hydrophobic modification of oral cavity surfaces |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2955984A (en) * | 1956-06-18 | 1960-10-11 | Bristol Myers Co | Dentifrices |
| FR2681663B1 (en) * | 1991-09-20 | 1994-12-23 | Air Liquide | CRYOGENIC FLUID TRANSFER LINE. |
| JP3783096B2 (en) * | 1998-07-30 | 2006-06-07 | サンスター株式会社 | Oral composition |
| US9139731B2 (en) * | 1999-11-12 | 2015-09-22 | The Procter & Gamble Company | Compositions and methods for improving overall tooth health and appearance |
| US6592852B1 (en) * | 2002-04-25 | 2003-07-15 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Zinc citrate beads in oral compositions |
| US8163271B2 (en) * | 2006-03-01 | 2012-04-24 | Dentech, Inc. | Oral hygiene products and method of using the same |
| JP5553396B2 (en) * | 2007-04-10 | 2014-07-16 | 株式会社サンギ | Remineralization accelerator and oral composition |
| WO2009134657A1 (en) * | 2008-04-28 | 2009-11-05 | The Procter & Gamble Company | Oral care compositions |
| US8747814B2 (en) * | 2009-08-17 | 2014-06-10 | The Procter & Gamble Company | Oral care compositions and methods |
-
2013
- 2013-11-22 WO PCT/CN2013/087671 patent/WO2015074241A1/en active Application Filing
- 2013-11-22 CA CA2929053A patent/CA2929053C/en not_active Expired - Fee Related
- 2013-11-22 MX MX2016006399A patent/MX2016006399A/en unknown
- 2013-11-22 CN CN201380080985.7A patent/CN105722843B/en active Active
- 2013-11-22 EP EP13883858.6A patent/EP3071580A1/en not_active Withdrawn
- 2013-11-22 AU AU2013406042A patent/AU2013406042B2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093058A (en) * | 1992-08-26 | 1994-10-05 | 美国健康基金会牙科协会 | The mineralising fluorination process and the composition of calcified tissue |
| CN102802732A (en) * | 2009-09-11 | 2012-11-28 | 宝洁公司 | Methods and compositions for hydrophobic modification of oral cavity surfaces |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105722843A (en) | 2016-06-29 |
| AU2013406042B2 (en) | 2017-04-27 |
| CA2929053A1 (en) | 2015-05-28 |
| EP3071580A1 (en) | 2016-09-28 |
| CA2929053C (en) | 2019-01-29 |
| WO2015074241A1 (en) | 2015-05-28 |
| AU2013406042A1 (en) | 2016-04-28 |
| MX2016006399A (en) | 2016-08-01 |
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