CN105722843A - Regimen for providing smooth tooth feel - Google Patents

Regimen for providing smooth tooth feel Download PDF

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Publication number
CN105722843A
CN105722843A CN201380080985.7A CN201380080985A CN105722843A CN 105722843 A CN105722843 A CN 105722843A CN 201380080985 A CN201380080985 A CN 201380080985A CN 105722843 A CN105722843 A CN 105722843A
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compositions
phosphate
weight
laureth
alkyl
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CN201380080985.7A
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CN105722843B (en
Inventor
R·斯特兰德
A·R·E·麦格雷戈
C·古多尔
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Procter and Gamble Ltd
Procter and Gamble Co
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Procter and Gamble Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/556—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Dental Preparations (AREA)

Abstract

The present invention provides a method of treating a tooth surface to provide smooth tooth feel benefits, comprising the steps: (a) contacting the tooth surface with a first composition comprising a water-insoluble calcium phosphate; and thereafter (b) contacting the tooth surface with a second composition comprising an organophosphate.

Description

For providing the scheme of the smooth sense of tooth
Technical field
A kind of method that the present invention relates to dental treatments surface, the method includes with the first compositions-treated dental surface and then with the second compositions-treated dental surface, to provide tooth smooth sense.
Background technology
Consumer routine use oral care product such as toothpaste and collutory are as a part for their oral care hygiene regimens.It is typically formulated oral care product to provide treatment beneficial effect and beauty treatment hygiene benefits.Treatment beneficial effect includes the prevention of dental caries, gingivitis prevention and allergy and controls.Beauty benefits includes controlling dental plaque and the formation of dental calculus, removal and prophylaxis of teeth are painted, the overall improvement of tooth whitening, breath freshening and mouth feel impression, and its feature is extensively in that mouth feel aesthetics.Smooth dental surface or tooth smooth feeling are typically considered thoroughly cleaning and effective signal of interest delivering these beneficial effects.
Abrasive material such as silicon dioxide and calcium carbonate are widely used in toothpaste to remove teeth stains tooth of polishing, thus smoothing dental surface and providing tooth smooth feeling.But, the abrasion of dental surface be may result in the damage of enamel abrasiveness by abrasive material.The damage of this type of abrasiveness includes enamel loss (such as scratch, minute fissure etc.) and enamel thinning, and it can make dental surface roughening and make less desirable antibacterial be easier to deposition and invade in tooth and therefore cause the destruction of enamel.On the other hand, after cleaning tooth in several minutes, the thin film that teeth stains is fixed is formed on adamantine surface from the glycoprotein of saliva usually by selective binding.After thin coating adheres to enamel, tooth smooth feeling can reduce rapidly.
Accordingly, there exist the needs solving this problem.Smooth dental surface is needed to be damaged to enamel without abrasiveness.Even if being also required to repair dental surface smoothness after enamel loss or thinning.Finally, it is necessary to provide lasting smooth effect for dental surface.
Summary of the invention
It is one or more that the present invention attempts to solve in these problems.In one aspect, the present invention provides a kind of method on dental treatments surface, and the method comprises the following steps:
A () makes described dental surface and contacts with the first compositions comprising water-insoluble calcium phosphate, wherein said water-insoluble calcium phosphate has the calcium of 1:1 to 10:1 and the mol ratio of phosphorus；And then
B () makes described dental surface and the contact of the second compositions, wherein said second compositions comprises the organic phosphate with following formula:
Wherein R is the alkyl comprising 4 to 22 carbon atoms；X and Y is each independently the alkylidene comprising 2 to 4 carbon atoms；A and b is each independently the integer selected from 0 to 20, and wherein a+b is in the scope of 0 to 20；Z1And Z2The alkyl preferably containing one or more ether moiety be each independently selected from hydrogen, comprising 1 to 26 carbon and counter ion counterionsl gegenions, precondition is Z1And Z2In at least one be hydrogen or counter ion counterionsl gegenions.
On the other hand, the present invention provides a kind of oral care kits, and described oral care kits includes:
A () first product containing the first compositions, wherein said first compositions comprises the water-insoluble calcium phosphate of by weight 0.01% to 99%, and described water-insoluble calcium phosphate has the calcium of 1:1 to 10:1 and the mol ratio of phosphorus；
(b) second product containing the second compositions, wherein said second product is the collutory to the viscosity of 5000cps of pH and the 100cps with 6 to 8, and wherein said second compositions comprises the organic phosphate as defined above of by weight 0.01% to 99%；With
C () description, described description instruction user, first by described first product contact dental surface, uses described second product to contact described dental surface immediately after.
In yet another aspect, the present invention provides the oral care product including the first container and second container, wherein said first container includes the first compositions, described first compositions comprises the water-insoluble calcium phosphate with the calcium of 1:1 to 10:1 and the mol ratio of phosphorus of by weight 0.01% to 99%, and described second container includes the second compositions, and described second compositions comprises the organic phosphate as defined above of by weight 0.01% to 99%；And wherein said product optionally includes description, this description instruction user distributed the first compositions before distribution the second compositions.
One aspect of the present invention is the commonly provided calcium source is applied on dental surface after use the order application system of specific organic phosphate.Without being bound by theory, it is believed that to use the first step in calcium source for the minute fissure sealing in tooth structure or gap, and it is believed that the second step using specific organic phosphate is for being sealed to calcium in tooth structure.By this order application system, by providing new crystal growth, reparation dental surface smoothness potentially in enamel loss or thinning area and/or building uniform cap layer so that dental surface smoothness persistently delivers discernable and significant improvement for dental surface.
For a person skilled in the art, by detailed description below, the these and other feature of the present invention, aspect and advantage will become clear from.
Accompanying drawing explanation
Although providing the claims defining and being distinctly claimed the present invention especially after description, it is believed that illustrate to be better understood the present invention by the following drawings.In the drawings,
Fig. 1 (a) to Fig. 1 (e) illustrates when coming dental treatments surface according to specific embodiments of the present invention, by the performance evaluation that dental surface is carried out by the quartz crystal microbalance with the monitoring (QCM-D) that dissipates.
Fig. 2 (a) to Fig. 2 (d) illustrates according to specific embodiments of the present invention, before process, etch with citric acid after, first process after step and the second scanning probe micro-(SPM) image processing the dental surface after step.
Fig. 3 (a) to Fig. 3 (d) illustrates according to comparing embodiment, before process, etch with citric acid after, first process after step and the second scanning probe micro-(SPM) image processing the dental surface after step.
Fig. 4 (a) to Fig. 4 (c) illustrates and compares embodiment according to another, before process, etch with citric acid after and a step process after scanning probe micro-(SPM) image of dental surface.
Fig. 5 illustrates after processing according to specific embodiments of the present invention and according to comparing after embodiment processes, about the tooth smooth feeling test result figure with the time of 3 hours.
Detailed description of the invention
" oral cavity composition " and " oral care composition " is used interchangeably herein, and refer to a kind of product, this product is not deliberately swallowed the Formulations for systemic administration for particular therapeutic agent in generally using process, but retain the sufficiently long time in the oral cavity, to contact dental surface and/or oral cavity tissue for topical.
Except as otherwise noted, as used herein, term " dentifrice " includes for cleaning the paste of tooth, gel, liquid, powder or tablet by toothbrush.Dentrifice composition can be single-phase composite, or can be the combination of two or more independent Dentrifice compositions.
As used herein, term " water-insoluble " means to have dissolubility in relatively low water and maybe can not be dissolved completely in water.Specifically, water-insoluble materials is intended to indicate that the material at 20 DEG C with the dissolubility being especially less than 1mg/l less than 1g/l.
As used herein, term " water solublity " means to have dissolubility in higher water and maybe can be dissolved completely in water.Specifically, water-soluble substances is intended to indicate that have, at 20 DEG C, the material being not less than the dissolubility that 1g/l is especially not less than 10g/l.
As used herein, term " granularity " refers to by the granularity based on volume that laser diffraction method measures.When laser diffraction is by Laser Measurement bundle traverse scattered particulate samples, particle size distribution is measured in the angle change of scattered light intensity.The scattering light of bigger particle is less relative to the angle of laser beam, and the scattering light of less particle is bigger relative to the angle of laser beam.Then, the Mie theory analysis angle scattering strength data of light scattering are used to calculate the granularity resulting in scatter pattern.Granularity is reported as equi-volume sphere diameter.Term " mean diameter " and " particle mean size " are used interchangeably herein, and it refers to the meansigma methods of the particle size distribution calculated based on logarithmic scale.
Term " alkyl ", " hydrocarbyl substituent " and " hydrocarbyl group " is used interchangeably herein, and it refers to the carbon atom with the remainder being directly connected to molecule and mainly has the monoradical of hydrocarbon character.This type of monoradical can be categorized as the combination (such as alkaryl and aromatic alkyl group) of aliphatic group, cyclic group or aliphatic group and cyclic group.Term " aliphatic group " means hydrocarbyl group saturated or undersaturated, straight or branched.This term is used for containing such as alkyl, thiazolinyl and alkynyl group.Term " alkyl group " means hydrocarbyl group saturated, straight or branched, and it includes such as methyl, ethyl, isopropyl, the tert-butyl group, heptyl, dodecyl, octadecyl, amyl group, 2-ethylhexyl etc..Term " alkenyl group " means to have the hydrocarbyl group of undersaturated, the straight or branched of one or more carbon-to-carbon double bond, such as vinyl groups.Term " alkynyl group " means to have the hydrocarbyl group of undersaturated, the straight or branched of one or more carbon-to-carbon triple bond.Term " cyclic group " means to be categorized as the closed loop alkyl of alicyclic group, aromatic group or heterocyclic group.Term " alicyclic group " means the cyclic hydrocarbon group that character is similar to the character of aliphatic group.Term " aromatic group " or " aromatic yl group " mean monokaryon or polynuclear aromatic hydrocarbyl group.
As referred to herein, term " viscosity " uses to have to bore and measures with the Brookfield viscometer of plate adnexa.For the viscosity within the scope of 0-16000cps, use the BrookfieldDV-II viscometer with S02 plate.Read before reading under 2.5rpm, make 500ml composition sample balance three minutes at 25 DEG C.For the viscosity more than 16000cps and at most 33000cps, use the BrookfieldDV-I viscometer with S02 plate.Read before reading under 0.3rpm, make 500ml composition sample balance 1 minute at 25 DEG C.
As used herein, " tooth " of term " tooth " or plural form refers to nature tooth and artificial teeth or artificial tooth.
Can be used for active substance herein and other composition can be classified according to the effect of their beauty treatment and/or treatment beneficial effect or their supposition or operational mode or describe.It should be appreciated, however, that in some cases, can be used for the active substance of the present invention and other composition can provide the beauty treatment of more than one and/or treat beneficial effect, or worked by the binding mode of more than one or run.Therefore, classification herein for convenience only, and is not intended to be limited in by composition in the listed one or more application particularly pointed out.
As used herein, time in for claim, article " " and " one " are understood to mean one or more claimed or according to claims materials.
As used herein, term " comprises ", " including ", " containing ", " having " are meant that nonrestrictive, can add other step and other composition of not affecting final result.Terms above contain term " by ... composition " and " substantially by ... form ".
As used herein, word " preferably ", " preferably " and their variant refer to the embodiment of the present invention that can provide specific beneficial effect in certain circumstances.But, other embodiment is alternatively preferred under identical or other environment.Additionally, it is disabled that the statement of one or more preferred embodiments is not offered as other embodiment, and it is not intended to get rid of other embodiment from the scope of the present invention.
Order application system
According to the present invention, it is provided that for the order application system on dental treatments surface.
In first step (a), dental surface contacts with the first compositions comprising water-insoluble calcium phosphate, and wherein said water-insoluble calcium phosphate has the calcium of 1:1 to 10:1 and the mol ratio of phosphorus.Water-insoluble calcium phosphate granules can be deposited in minute fissure and gap, to provide the source of calcium ion and phosphate anion to come enamel Remineralization.
In second step (b), dental surface contacts with the second compositions comprising organic phosphate as defined above further.Organic phosphate can form protective layer at dental surface, in order to calcium ion and phosphate anion is sealed in tooth structure.
In a specific embodiment, terminate in latter 30 minutes, in 15 clocks, in 5 minutes in contact procedure (a) or immediately come into contact with step (b).Preferably in the dental procedure step being absent between step (a) and step (b) between two parties.
Contact procedure can by realizing selected from following any oral care hygiene regimens: such as brushing, dental floss tooth-cleaning, rinses, smear, be attached and their combination.Therefore, the first compositions and the second compositions can be advantageous for the various forms of oral care hygiene regimens.This type of form includes but not limited to for directly using or be attached to the toothpaste of dental surface, dentifrice, gutta-percha, dental floss, collutory, chewable tablet, chewing gum or bar or film.In a specific embodiment, the first compositions is dentifrice composition, and the second compositions is collutory.In another specific embodiment, the first compositions and the second compositions are each independently collutory.
Duration of contact depends on concrete scheme and concrete composition forms.Such as, brush with toothpaste and can carry out 1 minute to 5 minutes, rinse with collutory and can carry out 5 seconds to 2 minutes, and smear with bar or film and can carry out 5 minutes to 60 minutes, it is preferable that 20 minutes to 40 minutes.
In a specific embodiment, contact procedure (a) and (b) have the duration of contact of 5 seconds to 5 minutes independently of one another；And after contact procedure (a) terminates, immediately come into contact with step (b).
In a specific embodiment, realize contact procedure (a) by brushing dental surface with the toothpaste comprising the first compositions, then pass through the collutory flushing dental surface with comprising the second compositions and realize contact procedure (b) immediately.
In another specific embodiment, realize contact procedure (a) by rinsing dental surface with the first collutory comprising the first compositions, then pass through the second collutory flushing dental surface with comprising the second compositions and realize contact procedure (b) immediately.
First compositions
Dental surface constantly stands loss and the gain of mineral.This process is come local by the chemical composition of saliva and extracellular fluid and is kept balance.The destruction of dental surface integrity can be there is in the abrasion caused by acid food and beverage, germ attack and tooth of excessively brushing teeth or mill.These processes, with the dental surface demineraliting exposed, cause rough surface.Therefore, according to the present invention, the first compositions provides the source of calcium ion and phosphate anion, and it is by depositing in the minute fissure of tooth structure and gap or on dental surface to enamel Remineralization.
In a specific embodiment, the first compositions comprises water-insoluble calcium phosphate, and wherein said water-insoluble calcium phosphate has the calcium of 1:1 to 10:1 and the mol ratio of phosphorus.
Calcium phosphate is present in the main mine material in tooth.Dentium nitor is made up of nearly hydroxyapatite of 90 percent, and it is known as the calcium phosphate mineral of bone mineral nitrogen.As discharged in physiological conditions for the water-insoluble calcium phosphate of the present invention and deliver a small amount of calcium ion and phosphate anion, to promote that the mineral nitrogen of dentium nitor is supplemented.
It has been found that it is important that the specific molar ratio scope of calcium and phosphorus is supplemented for the mineral nitrogen of dental health and dentium nitor.Too high calcium and phosphorus ratio possibly cannot suppress the tartar on the dental caries of corona and/or tooth effectively, and too low calcium and phosphorus ratio possibly cannot effectively suppress the dental caries near gingiva and/or can increase inflammatory and be inclined to such as pyorrhea and gingivitis.In a specific embodiment, water-insoluble calcium phosphate has the calcium of 1:1 to 5:1 or 1:1 to 3:1 or 1.5:1 to 2.5:1 or 1.3:1 to 2:1 and the mol ratio of phosphorus.
Can be used for the suitable water-insoluble calcium phosphate of the present invention and include but not limited to apatite, phosphoric acid halogen calcium, dicalcium phosphate, tricalcium phosphate, OCP and their mixture.In one embodiment, apatite is selected from: hydroxyapatite (Ca10(PO4)6(OH)2), fluor-apatite (Ca10(PO4)6F2), chlorapatite (Ca10(PO4)6Cl2), bromine apatite (Ca10(PO4)6Br2) and their mixture.
Water-insoluble calcium phosphate can be any solid form, for instance is substantially in the form of spherical granule, the agglomerate of smaller particle, rod-shpaed particle, elongated piece, fibrous particle or their mixture.
Water-insoluble calcium phosphate can for any size that can deposit on dental surface and the essence not damaging the present invention.In a specific embodiment, water-insoluble calcium phosphate has the granularity of 0.01 micron, 0.5 micron, 1 micron, 2 microns or 4 microns to 5 microns, 8 microns, 10 microns, 15 microns or 20 microns.
According to the present invention, the geometry of water-insoluble calcium phosphate granules and size can be optimized, in order to the various minute fissures on dental surface and gap are accounted for.
Water-insoluble calcium phosphate is to exist by the amount of the weighing scale 0.01%, 0.05%, 0.1%, 0.5%, 1% or 2% to 3%, 5%, 10%, 20%, 50% or 99% of the first compositions.In a specific embodiment, the first compositions comprises the apatite of by weight 0.1% to 20%.In another specific embodiment, the first compositions comprises the hydroxyapatite of by weight 1% to 5%.The amount of the insoluble calcium phosphate of adjustable water, to provide desired technology and sense organ beneficial effect, reduces any side effect simultaneously.In some medical treatment or clinical case, when side effect is inessential, the amount of water-insoluble calcium phosphate can be up to 99% by the weighing scale of the first compositions.
The pH of the first compositions can in the scope of about 6,7 or 8 to 9,10 or 11.PH can be realized by the appropriate balance of calcium phosphate source or interpolation alkaline agent or acidizer.Without being bound by theory, it is preferable that relatively in the pH of alkalescence, reason is to it is believed that described pH stablizes water-insoluble calcium phosphate from dissolving.
Second compositions
According to the present invention, the second compositions comprises specific organic phosphate compound.Enamel surfaces such as tooth is had strong affinity by organic phosphate compound, and has sufficient surface combination tendency, so that surface membrane protein matter desorbing, and remain attached to enamel surfaces.Without being bound by theory, it is believed that when using according to the present invention, organic phosphate compound is attached to tooth, and phosphate group, in conjunction with the calcium in tooth, therefore prevents calcium to be dissolved in acidic saliva loss.Organic phosphate also can deposit the protectiveness surface coating preventing tooth from directly contacting with aggressivity acid or other harmful substance.
Especially, the second compositions comprises the organic phosphate with following formula:
Wherein R is the alkyl comprising 4 to 22 carbon atoms；X and Y is each independently the alkylidene comprising 2 to 4 carbon atoms；A and b is each independently the integer selected from 0 to 20, and a+b is in the scope of 0 to 20；Z1And Z2The alkyl preferably containing one or more ether moiety be each independently selected from hydrogen, comprising 1 to 26 carbon and counter ion counterionsl gegenions, precondition is Z1And Z2In at least one be hydrogen or counter ion counterionsl gegenions.
Can be used for the example of hydrocarbyl group herein to include but not limited to；(1) hydrocarbon substituent, namely aliphatic series (such as alkyl or alkenyl), alicyclic (such as cycloalkyl, cycloalkenyl group) substituent group and aromatics-, the aromatic substituent of aliphatic series-and alicyclic-replace and cyclic substituents and equivalent thereof, wherein said ring forms (such as, two substituent groups collectively form alicyclic group) by another part of molecule；(2) hydrocarbon substituent replaced, namely comprising the substituent group of non-alkyl, this non-alkyl does not change main hydrocarbon substituent (such as halogen (especially chlorine and fluorine), hydroxyl, alkoxyl, sulfydryl, alkyl thiol, nitro, nitroso-group and sulfur oxygen base) and equivalent thereof in context described herein；(3) assorted-substituent group, namely in context described herein, comprises non-carbon and equivalent thereof when substituent group mainly has hydrocarbon character in the ring being made up of carbon atom or in the chain of alternate manner.Hetero atom includes sulfur, oxygen, nitrogen, and contains substituent group such as pyridine radicals, furyl, thienyl and imidazole radicals.In a specific embodiment, in hydrocarbyl group, every ten carbon atoms exist less than two, preferably more than a substituents.In another specific embodiment, hydrocarbyl group is absent from substituents.
It is believed that the existence of hydrocarbyl group gives compound hydrophobic deg so that organic phosphate can be effectively formed hydrophobic layer on tooth surfaces.This type of hydrophobic layer can make enamel avoid aggressivity acid attack and grime, and provides long-acting good smooth sense.
Some examples of organic phosphate include but not limited to alkylphosphonic and alkyl (gathering) alkoxy phosphate, such as lauryl phosphate (trade name MAP230K and MAP230T, can be commercially available from Croda (Snaith, UK))；PPG5 cetearyl polyoxyethylene ether-10 phosphate (CrodaphosSG, can be commercially available from Croda (Snaith, UK))；(trade name MAPL210, can be commercially available from Rhodia (LaD é fense, France) for laureth-1 phosphate；PhostenHLP-1, can be commercially available from NikkolChemical (Tokyo, Japan)；Or SunmaepL, can be commercially available from SunjinChemical (Korea))；(trade name MAPL130, can be commercially available from Rhodia (LaD é fense, France) for laureth-3 phosphate；FoamphosL-3, can be commercially available from Alzo (NJ, U.S.)；Or EmphiphosDF1326, can be commercially available from HuntsmanChemical (Texas, U.S.))；Laureth-9 phosphate (trade name FoamphosL-9, can be commercially available from Alzo (NJ, U.S.))；Three laureth-4 phosphate (trade name HostaphatKL340D, can be commercially available from Clariant (Muttenz, Switzerland))；Or TLP-4, can be commercially available from NikkolChemical (Tokyo, Japan))；C12-18PEG9 phosphate (trade name CrafolAP261, can be commercially available from Cognis (Ludwigshafen, Germany))；Dilauryl polyoxyethylene ether-10 sodium phosphate (trade name DLP-10, can be commercially available from NikkolChemical (Tokyo, Japan)).
Specifically, it is preferred that organic phosphate is to comprise alkoxy base, the alkoxy base (O-X) especially repeateda(O-Y)bThose, particularly comprise those of one or more ethyoxyls, propoxyl group, isopropoxy, butoxy radicals or their combination.It is believed that the existence of alkoxy base increases the dissolubility of compound the amphipathic of equilibrium compound so that hydrophilic phosphate head can " adhere to " to dental surface (giving its electric charge), and hydrophobicity hydrocarbon tail extends to Long carbon chain simultaneously.On the other hand, the existence of alkoxy base can help to material and diffuses out from dental surface.
Additionally suitable organic phosphate can include alkyl monoglyceride phosphate, alkyl sorbitan alcohol phosphate, alkyl methyl glucoside phosphate, alkyl sucrose phosphate, glucosan phosphate, poly glucoside phosphate, alkyl polyglucoside phosphate, poly-glycerine phosphate, alkyl poly-glycerine phosphate, polyethers phosphate and alkoxylated polyol phosphate.Some concrete examples can include Polyethylene Glycol (PEG) phosphate, polypropylene glycol (PPG) phosphate, alkyl PPG phosphate, PEG/PPG phosphate, alkyl PEG/PPG phosphate, PEG/PPG/PEG phosphate, dipropylene glycol phosphate, PEG glycerophosphate, polytetramethylene glycol (PBG) phosphate, PEG cyclodextrin phosphate, PEG sorbitan phosphate, PEG alkyl sorbitan alcohol phosphate, PEG methyl glucosamine phosphate and their combination.
Organic phosphate can provide desired surface conditioning effects, including: 1) effective desorbing of the membrane proteins of less desirable absorption, especially adhere to teeth stains, dental calculus is formed and the absorption of less desirable microbe species is relevant desorbing；And 2) after using product, make surface conditioning effects and the control that thin film is formed keep the long period.The compositions of the present invention is by providing protectiveness surface coating in conjunction with calcium mineral (such as hydroxyapatite) in tooth.The opposing of the erosion of acid is provided the tooth surface characteristics of improvement by changing surface hydrophilicity and hydrophobicity improvement by described protectiveness surface coating.
In second compositions, the amount of organic phosphate is available to the effective dose of the good smooth sense of one period of expected time of protective layer.Preferably, described protection continues at least one hour after using described compositions.Described organic phosphate can exist by effective dose, and to provide at least 10 increases spent of water contact angle on described surface, and described hydrophobicity is kept the time of at least 5 minutes.In a specific embodiment, described organic phosphate is to exist by the weighing scale of the second compositions amount in the scope of 0.01%, 0.02%, 0.03%, 0.05%, 0.07% or 0.1% to 0.5%, 1%, 5%, 10%, 50% or 99%.The amount of scalable organic phosphate, to provide desired technology and sense organ beneficial effect, reduces any side effect simultaneously, and under described side effect, organic phosphate compound can have such as less desirable bitterness or soapy flavor.In some medical treatment or clinical case, when being not enough to consider less desirable bitterness or soapy flavor, the amount of organic phosphate can be up to 99% by the weighing scale of the second compositions.
In a specific embodiment, organic phosphate is by defined below: R is the alkyl comprising 8 to 16 carbon atoms；A+b is 1 to 10；And Z1And Z2It is each independently selected from hydrogen and alkali metal counter ion counterionsl gegenions.Preferably, Z1And Z2In at least one be the alkali metal counter ion counterionsl gegenions selected from sodium ion and potassium ion；And wherein said second compositions comprises the organic phosphate of by weight 0.01% to 10%.
Specifically, described organic phosphate is selected from: laureth-1 sodium phosphate, laureth-2 sodium phosphate, laureth-3 sodium phosphate, laureth-4 sodium phosphate, laureth-1 potassium phosphate, laureth-9 sodium phosphate, myristyl polyoxyethylene ether-2 sodium phosphate, alkyl polyoxyethylene ether-1 sodium phosphate and their mixture.
In a specific embodiment, the second compositions comprises laureth-1 sodium phosphate of by weight 0.01% or 0.05% to 5% or 10%.
The pH of the second compositions can in the scope of 5,6 or 6.5 to 7.5,8 or 10.The pH of the second compositions should be not too low, and reason is that organic phosphate is likely in strong acidic environment to be hydrolyzed.
Optional components
First compositions of the present invention and the second compositions can comprise the multiple optional conventional constituents that can be used for oral cavity composition independently of one another, to increase beneficial effect mentioned herein or to provide additional beneficial effect.This type of optional components includes but not limited to fluoride ion source, thickening agent, wetting agent, surfactant, antibacterial, coloring agent, flavoring agent and some other conventional constituents.
The fluoride ion source of free fluorion can be provided also referred to as soluble fluoride source, the local supersaturation of fluorinated phosphate doped calcium thing can be promoted, and mineral nitrogen is supplemented accelerate by increasing.Fluoride picked-up or fluoride refer to and cause fluoride to collect in dentine by fluoride reagents Local treatment.The tooth that Remineralization and fluoride picked-up strengthen shows the resistance to acid demineraliting of excellence, thus contributing to making the smooth effect of dental surface lasting.Soluble fluoride source is selected from: sodium fluoride, stannous fluoride, sodium monofluorophosphate, amine fluoride and their mixture.In a specific embodiment, described second compositions comprises the soluble fluoride source of the free fluoride ion that can provide 50ppm, 500ppm, 1000ppm or 1500ppm to 2000ppm, 2500ppm, 3000ppm or 3500ppm.In another specific embodiment, described second compositions comprises the sodium fluoride of by weight 0.005%, 0.01% or 0.02% to 0.1%, 1% or 5%.In even another specific embodiment, described first compositions comprises the hydroxyapatite of by weight 1% to 5%, and described second compositions comprise by weight 0.05% to 5% laureth-1 sodium phosphate and by weight 0.01% to 1% sodium fluoride.
Thickening agent (also referred to as thickening agent) is generally used for increasing the viscosity of solution or liquid/solid mixtures.According to the present invention, thickening agent can be mixed and be supplied to the desired denseness of consumer and tooth coating ability with the viscosity by adjustment compositions.The delivery form of root Ju compositions, the oral care composition of the present invention can have 10cps, 50cps, 100cps, 500cps, 800cps, 1200cps or the range of viscosities of 2000cps to 3000cps, 5000cps, 8000cps, 12000cps, 20000cps, 30000cps or 45000cps.In a specific embodiment, described first compositions has the viscosity of 2000cps to 8000cps.In another specific embodiment, described second compositions has the viscosity of 1200cps to 3000cps.Thickener composition tends to provide more lasting beneficial effect at dental surface.Thickening agent also can improve the suspension of insoluble composition, to provide stable and uniform compositions.When the first compositions comprising water-insoluble calcium phosphate is collutory, this point is especially beneficial.Preferred thickening agent is selected from: carboxy vinyl polymer, carrageenin, xanthan gum, cellulosic polymer, hydroxyethyl cellulose, carboxymethyl cellulose, ammonium acryloyldime-thyltaurate/vinylpyrrolidone copolymer, poly(ethylene oxide), acrylate/C10-30 alkyl acrylate cross-linked polymer, polyacrylic acid, cross linked polyacrylate, polycarbophil, alginate, clay, glucose, pectin, gelatin and their compositions.The silicon dioxide of colloidal magnesium aluminum silicate or segmentation also is used as a part for thickening agent to improve texture further.Thickening agent can exist by the amount of the weighing scale 0.01%, 0.1%, 0.2%, 0.3% or 0.4% to 2%, 5%, 8%, 10% or 20% of the first compositions or the second compositions.
Wetting agent such as Polyethylene Glycol can also be used for improving viscosity and providing smooth sense to Dentrifice composition.Can obtaining bigger average molecular weight range and have the Polyethylene Glycol of different performances, described performance depends on their mean molecule quantity.Wetting agent is used for avoiding described oral cavity composition especially dentifrice composition being exposed to the after-hardening of air, and gives oral area damp.Some wetting agent also can give the oral cavity composition desired sweet taste of such as collutory and toothpaste.Suitable humectants for the present invention includes edible polyhydric alcohol such as glycerol, sorbitol, xylitol, butanediol, Polyethylene Glycol, propylene glycol and their mixture.Wetting agent is optionally to exist by the amount of the weighing scale 1%, 2%, 5% or 8% to 15%, 25%, 50% or 70% of the first compositions or the second compositions.
Surfactant can be used for such as making other component of oral care composition more compatible each other.This provides the stability strengthened, and contributes to by washing teeth surfaces, and provides foam when such as stirring during brushing with the Dentrifice composition of the present invention.Can using any oral acceptable surfactant, its major part is the surfactant of anion, nonionic or both sexes.Suitable anion surfactant unrestrictedly includes the water soluble salt of C8-20 alkyl sulfate, the sulfonated monoglycerides of C8-20 fatty acid, sarcosinate, taurate etc..The exemplary example of these and other type includes sodium lauryl sulfate, coconut monoglyceride sodium sulfonate, sodium lauryl sarcosinate, the different ethionine sodium of lauryl, laureth carboxylic acid sodium and dodecylbenzene sodium sulfonate.
Suitable nonionic surfactant unrestrictedly includes poloxamer, polyoxyethylene sorbitan ester, fatty acid ethoxylate, alkylphenol ethoxylate, tertiary amino oxides, phosphine oxides, dialkyl sulphoxide etc..Suitable amphoteric surfactant unrestrictedly includes the derivant of C8-20 aliphatic secondary amine and the tertiary amine with anionic group such as carboxylate radical, sulfate radical, sulfonate radical, phosphate radical or phosphonate radical.Suitable example is cocoamidopropyl.Surfactant optionally exists by the amount of the first compositions or the weighing scale 0.01%, 0.05% or 0.1% to 2%, 5% or 10% of the second compositions.
Can be used for the antibacterial of the present invention and include but not limited to water-insoluble non-cationic antimicrobial agent and water-soluble antimicrobial, such as quaternary ammonium salt and double; two two guanidinesalts.Triclosan monophosphate is additional water-soluble antimicrobial.In certain preferred aspects, antibacterial is selected from: halogenation cetyl pyridinium, halogenation domiphen bromide, stannous ion source, zinc ion source, copper ion source and their mixture.Antibacterial can exist by the amount of the weighing scale 0.01%, 0.05%, 0.1% or 0.2% to 0.5%, 1.0%, 1.2% or 1.5% of the first compositions or the second compositions.
Coloring agent herein includes the reagent such as pearling agent of the specific gloss of pigment, dyestuff, color lake and imparting or reflectance.Coloring agent can realize several functions, it includes such as providing white or light coating on tooth surfaces, serve as the indicator in site on the dental surface effectively contacted by compositions, and/or modifying composition outward appearance especially color and/or opacity are to increase the captivation to user.Can using any oral acceptable coloring agent, it includes but not limited to Talcum, Muscovitum, magnesium carbonate, calcium carbonate, magnesium silicate, aluminium-magnesium silicate, silicon dioxide, titanium dioxide, zinc oxide, redness, yellow, brown and black iron oxide, ferriferro cyanide ammonium, manganese violet, ultramarine pigment, metatitanic acid Muscovitum, bismuth oxychloride etc..
Flavoring agent can be used for the taste of such as enhancing composition.Any oral acceptable naturally occurring or synthetic flavoring agent can be used, it includes but not limited to vanillin, Salvia japonica Thunb., origanum, parsley oil, Oleum Menthae Rotundifoliae, Oleum Cinnamomi, wintergreen oil (methyl salicylate), Fructus Piperis peppermint oil, Oleum Caryophylli, laurel fat, oleum anisi, Eucalyptus oil, citrus oils, fruit oil and essence (include derived from Fructus Citri Limoniae, Fructus Citri junoris, Citrus aurantium Linn., grapefruit, Fructus Pruni, Fructus Musae, Fructus Vitis viniferae, Fructus Mali pumilae, Fructus Fragariae Ananssae, Fructus Pruni pseudocerasi, those of Fructus Ananadis comosi etc.), bean and nut (such as coffee bean, cacao bean, cola, peanut, Semen Armeniacae Amarum etc.) derivative flavoring agent, the flavoring agent etc. with encapsulating of absorption.Flavoring agent herein is also contemplated by mouth provides fragrance and/or other sensory effects to include refrigerant or warm effect composition.Specific examples of such components is exemplary includes menthol, menthyl acetate, menthyl lactate, Camphora, Eucalyptus oil, eucalyptol, anethole, eugenol, Cortex cinnamomi japonici (Ramulus Cinnamomi), alkanone, α-ionone, 1-ethoxy-2-hydroxy-4-propenyl benzene, thymol, linalool, benzaldehyde, cinnamic aldehyde, N-ethyl-p-Herba Menthae-3-Methanamide, N, 2,3-trimethyl-2-butanamide, 3-(1-Herba Menthae oxygen base) the third-1,2-glycol, cinnamic aldehyde glycerine acetal (CGA), MGA (MGA) etc..
Oral care kits and product
The present invention also provides for any type of external member and comprises the product of the first compositions as above and the second compositions.
In some embodiments, described oral care kits includes:
A () first product containing the first compositions, wherein said first compositions comprises the water-insoluble calcium phosphate of by weight 0.01% to 99%, and described water-insoluble calcium phosphate has the calcium of 1:1 to 10:1 and the mol ratio of phosphorus；
(b) second product containing the second compositions, wherein said second product is the collutory to the viscosity of 5000cps of pH and the 100cps with 6 to 8, and wherein said second compositions comprises the organic phosphate as defined above of by weight 0.01% to 99%；With
C () description, its instruction user, first by described first product contact dental surface, uses described second product to contact described dental surface immediately after.
In some embodiments, described external member farther includes to use the first compositions and/or the application device of the second compositions to dental surface, for instance make compositions be deposited on the injector type application device of dental surface or for compositions is applied to the semicircle flute profile application device of dental surface.External member also optionally includes the description of the purposes about the application device that compositions is applied to dental surface.
In a specific embodiment, described first product and described second product can be physically isolated, and are each independently any appropriate format, for instance liquid form or dry powder.When the compositions provided is dry powder, described compositions can be passed through to add suitable solvent (may also comprise in external member) and be reconstructed.In some embodiments, when providing liquid form, described compositions can be concentration or be instant.
In a specific embodiment, described first product and described second product are each independently collutory.
In some embodiments, it is desirable to provide include the single oral care product of the first container and second container, wherein said first container includes the first compositions, this first compositions comprises the water-insoluble calcium phosphate with the calcium of 1:1 to 10:1 and the mol ratio of phosphorus of by weight 0.01% to 99%, and described second container includes the second compositions, this second compositions comprises the organic phosphate as defined above of by weight 0.01% to 99%.Described product optionally includes description, and its instruction user distributed the first compositions before distribution the second compositions.
In a specific embodiment, single oral care product farther includes description, first its instruction user distributes the first compositions to contact dental surface when using every time from the first container, then distributes the second compositions from second container to contact dental surface.
In another specific embodiment, single oral care product farther includes pump, and when application processing scheme every time, described pump pumps the first compositions when first activates from the first container, and pumps the second compositions when activating second from second container.
Embodiment:
Following example further describe and demonstrate the embodiment in the scope of the invention.These embodiments given are merely illustrative, unintelligible for being limitation of the present invention, because can carry out many modification when without departing from the spirit and scope of the invention.
First compositions
Table 1 illustrates the embodiment of first compositions according to the present invention of mouthwash form.Preparation method is as follows: mixing to first and add glycerol and polymer in container, mixing is until fine dispersion is to obtain pre-composition 1；Mixing to second and add water (the 10% of total amount), flavoring agent & sensory agent, hydroxyapatite, sweeting agent, liquid preservative, surfactant and attractive in appearance dose of coloring agent & (aesthetics) in container, mixing is until fine dispersion and uniformly to obtain pre-composition 2；Adding water (the 90% of total amount), solid preservative and thickening agent in main mixing channel, mixing is until uniformly to obtain main mixture；Being added in main mixture by pre-composition 1, mixing is until fine dispersion；Being added in main mixture by 25% (if applicable) of sodium hydroxide total amount, mixing is until uniformly；Being added in main mixture by pre-composition 2, mixing is until fine dispersion and uniformly；And add remaining sodium hydroxide until pH is 7.
Table 1
1)Hydroxyapatite, is supplied by Bio-Rad (Hercules, CA, USA).
2)Hydroxyapatite, is supplied by Fluidinova (MoreiradaMaia, Portugal).
As collutory, suitable viscosity will make hydroxyapatite is suspended in compositions equably and advantageously combined thing is suitable contact and is held in dental surface.First compositions A1 to A8 is respectively provided with the viscosity of 2580cps, 7690cps, 5072cps, 2600cps, 29433cps, 132cps, 220cps and 116cps.
Table 2 illustrates the embodiment of first compositions according to the present invention of toothpaste form.Preparation method is as follows: water, wetting agent, part flavoring agent, coloring agent, buffer and activating agent are added in the main mixing channel of 35 DEG C, is sufficiently mixed and guarantees that all of composition has dissolved or fully dispersed；Being added in main mixing channel by thickening agent and sweeting agent, mixing homogenizing are until fully dispersed and uniform；Adding abrasive material, mixing homogenizing are until fully dispersed and uniform；Degassed；Being added in main mixing channel by the flavoring agent of surfactant solution, remainder, mixing homogenizing are until uniformly；Degassed；Pump out and cool down batch of material to lower than 40 DEG C.
Table 2
1) hydroxyapatite, is supplied by Bio-Rad (Hercules, CA, USA).
2) hydroxyapatite, is supplied by Fluidinova (MoreiradaMaia, Portugal).
Second compositions
Table 3 illustrates the embodiment of second compositions according to the present invention of mouthwash form.Preparation method is identical with the preparation method of the first compositions of mouthwash form, the difference is that in pre-composition 2 without hydroxyapatite and sodium fluoride is added with organic phosphate together with water (the 90% of total amount), solid preservative and thickening agent obtain main mixture.
Table 3
3) laureth-1 phosphate ester supplied by Rhodia, through preneutralization
4) laureth-9 phosphate ester supplied by Alzo, neutralizes with NaOH
Second compositions B3 to B7 is respectively provided with the viscosity of 3072cps, 1376cps, 216.5cps, 1408cps and 2616cps.Do not measure B1 and B2.
Table 4 illustrates the embodiment of second compositions according to the present invention of non-ground gutta-percha form.Preparation method is as follows: mineral oil/vaseline/Versagel, wetting agent, part flavoring agent and coloring agent are added in the main mixing channel of 35 DEG C, is sufficiently mixed and guarantees that all of composition has dissolved or fully dispersed；Being added in main mixing channel by organic phosphate and sweeting agent, mixing homogenizing are until fully dispersed and uniform；Degassed；Being added in main mixing channel by the flavoring agent of surfactant solution, remainder, mixing homogenizing are until uniformly；Degassed；Pump out and cool down batch of material to lower than 40 DEG C.
Table 4
Composition B8 B9 B10 B11 B12
MAP L-1305) 13.330 - - - -
Foamphos L-36) - 8.000 - - -
MAP 230K7) - - 10.000 - -
DLP-108) - - - 5.000 -
Crodaphos SG9) - - - - 2.000
Glycerol 20.000 13.000 22.000 35.000 -
Flavoring agent 2.000 2.000 2.000 2.000 1.000
Saccharin 0.500 0.500 0.500 0.500 2.000
Poly(ethylene oxide) 2.000 2.000 2.000 2.000 -
Carpobol 956 Carbomer 956. 0.500 0.500 0.500 0.500 -
Mineral oil - - - 55.000 -
Vaseline 61.670 64.000 63.000 - -
Versagel - - - - 95.000
Amount to 100 100 100 100 100
5) laureth-3 phosphate ester supplied by Rhodia, neutralizes with NaOH
6) laureth-3 phosphate ester supplied by Alzo, neutralizes with NaOH
7) C12/13 potassium phosphate, is supplied by Croda
8) dilauryl polyoxyethylene ether-10 sodium phosphate supplied by NikkolChemical
9) PPG5 cetearyl polyoxyethylene ether-10 phosphate ester supplied by Croda, neutralizes with NaOH
Order application system
A kind of and in the second compositions as shown in Table 3 and Table 4 one in the first compositions as shown in Table 1 and Table 2 can be attached in order oral administration processing scheme.The embodiment of the der group compound according to the present invention illustrates in table 5.
Table 5
By the collutory of 20ml being aspirated in mouth and containing spuing after coughing 30 seconds, the compositions of mouthwash form being applied to dental surface.In using, when theme composition is too viscous or too thick and cannot aspirate in mouth or containing, when coughing, suitable application device such as swab being used compositions to be used (such as sprawl or smear) to dental surface.
The compositions of toothpaste form was applied to dental surface in 2 minutes by brushing with toothbrush.
Upper 10 minute the compositions of gutta-percha form was applied to dental surface by being uniformly administered to by gutta-percha in dens supporter and dens supporter being placed in tooth.
Effect is measured
Quartz crystal microbalance (QCM-D) with the monitoring that dissipates
QCM-D is very sensitive mass balance technology, its adsorption dynamics adsorption kinetics and viscoelasticity of allowing simultaneously to measure adsorption layer.
In QCM-D, quartz crystal is encouraged to vibrate on its basic resonance frequency by AC voltage puts on crystal two ends.The material being adsorbed onto on plane of crystal causes resonant frequency to change, and it is proportional to the quality of adsorbed film.
Damping/the dissipation of the crystal oscillation for film can be measured, enabling measure the viscoelasticity of film.
Δ D=EDissipate/2πEStore
Wherein D is that the energy of vibration dissipation every time is divided by the gross energy stored in crystal.
Bigger Δ D value shows that softer, deformable material attaches to crystal.Rigid material causes less Δ D.
Fig. 1 (a) illustrates the QCM-D data of the dental surface processed with embodiments of the invention 1 to 1 (e).
Test dental surface is processed in sequential order in accordance with three steps.First step is to use deionized water rinsing dental surface.Second step is to rinse dental surface with the first compositions A2.Third step is to rinse dental surface further with the second compositions B6.Three posts of Fig. 1 (a) to figure each in 1 (e) represent QCM-D test result after each step.
Can find out from QCM-D data, before processing according to the present invention, dental surface not form adsorption layer.After by the first compositions-treated, it is shown that viscoelastic layer is adsorbed onto on dental surface.After processing further by the second compositions, strengthen adsorption layer by increasing quality, density and thickness.
Scanning probe microscopy method (SPM)
Scanning probe microscopy method is for producing the surface topography image of nano-scale resolution.In the art, the flexure of the cantilever spring of monitoring microfabrication, reason is its enterprising line raster scanning on the surface considered.Surface roughness analysis allows quantitative measurement as the shape characteristic of the function of surface modification feature.
Fig. 2 (a) to Fig. 2 (d) is shown in the change of enamel surfaces when processing with embodiments of the invention 1.Enamel surfaces (i.e. comparison) coarse before illustrating process for Fig. 2 (a).Fig. 2 (b) illustrates that enamel surfaces is by the further roughening with citric acid etching.Fig. 2 (c) is shown in slightly smooth enamel surfaces after processing with the first compositions A2 but deposition has some insoluble component (larger particles).It is believed that hydroxyapatite has deposited on surface.Fig. 1 (d) illustrates enamel surfaces smooth after processing subsequently with the second compositions B6.
By contrast, the change of enamel surfaces when Fig. 3 (a) to Fig. 3 (d) is shown in by the compositions identical with embodiments of the invention 1 but processes with different order.In other words, enamel surfaces is compared with the first compositions A2 process after processing with the second compositions B6.Enamel surfaces (i.e. comparison) coarse before illustrating process for Fig. 3 (a).Fig. 3 (b) is shown in the coarse enamel surfaces being similar to Fig. 2 (b) with citric acid after etching.Fig. 3 (d) is shown in enamel surfaces more smoother than Fig. 2 (c) after processing with the second compositions B6.But, after carrying out two-step pretreatment with the first compositions A2 after with the second compositions B6, the enamel surfaces that Fig. 3 (d) illustrates is more coarse than the enamel surfaces shown in Fig. 2 (d).Compared with the degree of depth of only 10nm in Fig. 2 (d), can up to the degree of depth of 20nm in 3 (d) protrusions or sunk area.
Additionally shooting SPM image is to illustrate with oralPro-Expert dentifrice (on March 18th, 2011 is produced in US) carries out the change of enamel surfaces after conventional treatment.OralPro-Expert dentifrice does not comprise the first compositions as defined herein or the second compositions.Fig. 4 (a) illustrates enamel surfaces coarse before processing.Fig. 4 (b) is shown through the enamel surfaces coarse further with citric acid etching.Fig. 4 (c) illustrates the enamel surfaces after dentifrice treatment, and it is almost equally coarse with the enamel surfaces of etching.Can be seen that dentifrice treatment is difficult to change enamel surfaces smoothness.
In a word, SPM data illustrate that treatment in accordance with the present invention makes dental surface more smooth.
Sensory test group inspection (DPP)
The sensory test group inspection of tooth smooth feeling is implemented by descriptive group (DPP), and described group is by through constituting 10 people of above-mentioned average sensory acuity and the sensory capacity screening describing tooth smooth feeling.Panelist undergoes training and evaluates the particular community of oral care product via Spectrum (TM) method, and has unrelated with individual's preference or preference, according to the unique ability that the attribute of evaluation oral care product is evaluated by attribute.In this test, panelist uses product, is simultaneous for its standard 3 hours cleaning mouthfeel ballots (including smooth tooth to measure), after a procedure instruction in 3 hours and evaluation products.Panelist also provides for descriptive analysis and additional random comment, it is proposed to other attribute of sensation any.Each attribute measures under 0-30 scale, and the interval of restriction was no longer than 15 minutes.After first hour, panelist drink 8oz/236.59mL soda pop (DecaffeinatedDietWith decaffeinated mealsOne of), proceed evaluation.
These inspection institute of appraisal group related products include: only the first compositions (A2)；Only the second compositions (B6)；The order application system using B6 after using A2 according to embodiments of the invention 1；The order application system of A2 is used after using B6；AndCollutory (comprises hydroxyapatite variant, on June 11st, 2011 is produced in British).
As it is shown in figure 5, according to the present invention use A2 after use the order application system of B6 and change over the tooth smooth feeling providing best.Although the order application system using A2 after using B6 is being provided that just after treatment tooth smooth feeling by comparison, but the value of tooth smooth feeling declined rapidly in 10 minutes after treatment.With after A2 sequential processing 20 minutes after with B6, the value of tooth smooth feeling obtain than the sequential processing according to the present invention those are low, and even than only obtain by A2 or B6 individual processing those are low.
Collutory is the commercial product of bag zinc-containing hydroxyapatite (zinchydroxyapatite).Can as can be seen from Figure 5, instant and lasting tooth smooth feeling evaluation obtain far below the sequential processing according to the present invention those.
Except as otherwise noted, all percentage ratios, ratio and ratio are based on the weighing scale of total composition.Except as otherwise noted, all temperature are all with degree Celsius (DEG C) for unit.Except as otherwise noted, all of measurement all carries out at 25 DEG C.All components or composition levels refer to the activity substance content of this component or compositions, and do not include impurity that may be present in commercial source, for instance residual solvent or by-product.
It should be understood that each greatest measure limit provided in this manual includes each lower numerical limitation, it is expressly written herein in this article such as this type of lower numerical limitation.The each minimum value limit provided in this manual will include each higher numerical limitation, be expressly written herein in this article such as this type of higher numerical limitation.The each numerical range provided in this manual will include each narrower numerical range being contained within the scope of this bigger numerical, also be expressly written herein in this article as the numerical range that this type of is narrower.
It is to be appreciated that dimension disclosed herein and value are not intended to be strictly limited to cited exact value.On the contrary, except as otherwise noted, otherwise each such dimension is intended to indicate that described value and around the functionally equivalent scope of this value.Such as, the dimension being disclosed as " 40mm " is intended to indicate that " about 40mm ".
Limit to some extent unless expressly excluded, or otherwise, each section of document cited herein, including any cross reference or Patents or application and the application to its any patent application requiring priority or its beneficial effect or patent, all it is incorporated herein by reference accordingly.Quoting of any document is not relative to any disclosed in this invention or claimed prior art herein accreditation to it, or is not individually or propose, advise or disclose the accreditation of this type of invention any with the combination with other one or more lists of references any to it.Additionally, when any implication of term or definition and any implication of same term in the file that is incorporated by reference or definition contradiction in the present invention, it should obedience gives implication or the definition of this term in the present invention.
Although having illustrate and described specific embodiments of the present invention, but it is obvious to those skilled in the art that can make various other when without departing from the spirit and scope of the invention changes and amendment.Therefore, it is intended in claims and contains these type of changes all and amendment of belonging in the scope of the invention.

Claims (20)

1. the method on dental treatments surface, said method comprising the steps of:
A () makes described dental surface and contacts with the first compositions comprising water-insoluble calcium phosphate, wherein said water-insoluble calcium phosphate has the calcium of 1:1 to 10:1 and the mol ratio of phosphorus；And then
B () makes described dental surface and the contact of the second compositions, wherein said second compositions comprises the organic phosphate with following formula:
Wherein R is the alkyl comprising 4 to 22 carbon atoms；X and Y is each independently the alkylidene comprising 2 to 4 carbon atoms；A and b is each independently the integer selected from 0 to 20, and a+b is in the scope of 0 to 20；Z1And Z2The alkyl be each independently selected from hydrogen, comprising 1 to 26 carbon and counter ion counterionsl gegenions, precondition is Z1And Z2In at least one be hydrogen or counter ion counterionsl gegenions.
2. method according to claim 1, wherein after contact procedure (a) terminates, came into contact with step (b) in 15 minutes.
3. method according to claim 2, wherein said water-insoluble calcium phosphate is selected from: apatite, phosphoric acid halogen calcium, dicalcium phosphate, tricalcium phosphate, OCP and their mixture.
4. method according to claim 3, wherein said first compositions comprises the apatite of by weight 0.1% to 20%.
5. method according to claim 4, wherein said first compositions comprises the hydroxyapatite of by weight 1% to 5%.
6. method according to claim 2, wherein said organic phosphate is by defined below: R is the alkyl comprising 8 to 16 carbon atoms；A+b is 1 to 10；And Z1And Z2It is each independently selected from hydrogen and alkali metal counter ion counterionsl gegenions.
7. method according to claim 6, wherein Z1And Z2In at least one be the alkali metal counter ion counterionsl gegenions selected from sodium ion and potassium ion；And wherein said second compositions comprises the organic phosphate of by weight 0.01% to 10%.
8. method according to claim 7, wherein said organic phosphate is selected from: laureth-1 sodium phosphate, laureth-2 sodium phosphate, laureth-3 sodium phosphate, laureth-4 sodium phosphate, laureth-1 potassium phosphate, laureth-9 sodium phosphate, myristyl polyoxyethylene ether-2 sodium phosphate, alkyl polyoxyethylene ether-1 sodium phosphate and their mixture.
9. method according to claim 8, wherein said second compositions comprises laureth-1 sodium phosphate of by weight 0.05% to 5%.
10. method according to claim 2, wherein said second compositions also comprises soluble fluoride source.
11. method according to claim 10, wherein said soluble fluoride source is selected from: sodium fluoride, stannous fluoride, sodium monofluorophosphate, amine fluoride and their mixture；Wherein said first compositions comprises the hydroxyapatite of by weight 0.1% to 20%；And wherein said second compositions comprises laureth-1 sodium phosphate of by weight 0.01% to 10%.
12. method according to claim 2, wherein said first compositions is dentifrice composition, and described second compositions is collutory.
13. method according to claim 2, wherein said first compositions and described second compositions are respectively collutory.
14. method according to claim 2, wherein said second compositions is collutory, and it has the viscosity of 100cps to 5000cps.
15. method according to claim 2, wherein said first compositions has the pH of 7 to 10.
16. method according to claim 2, wherein said second compositions has the pH of 6 to 8.
17. method according to claim 2, wherein said contact procedure (a) and (b) have the duration of contact of 5 seconds to 5 minutes independently of one another；And after described contact procedure (a) is terminated, immediately begin to described contact procedure (b).
18. method according to claim 17, wherein said first compositions is the collutory of the hydroxyapatite comprising by weight 1% to 5%, and described second compositions be comprise by weight 0.05% to 5% laureth-1 sodium phosphate and by weight 0.01% to 1% the collutory of sodium fluoride；And wherein said second compositions has the viscosity of pH and the 1000cps to 3000cps of 6.5 to 7.5.
19. an oral care kits, described oral care kits includes:
A () first product containing the first compositions, wherein said first compositions comprises the water-insoluble calcium phosphate of by weight 0.01% to 99%, and described water-insoluble calcium phosphate has the calcium of 1:1 to 10:1 and the mol ratio of phosphorus；
(b) second product containing the second compositions, wherein said second product is the collutory to the viscosity of 5000cps of pH and the 100cps with 6 to 8, and wherein said second compositions comprises the organic phosphate with following formula of by weight 0.01% to 99%:
Wherein R is the alkyl comprising 4 to 22 carbon atoms；X and Y is each independently the alkylidene comprising 2 to 4 carbon atoms；A and b is each independently the integer selected from 0 to 20, and a+b is in the scope of 0 to 20；Z1And Z2The alkyl be each independently selected from hydrogen, comprising 1 to 26 carbon and counter ion counterionsl gegenions, precondition is Z1And Z2In at least one be hydrogen or counter ion counterionsl gegenions；With
C () description, described description instruction user, first by described first product contact dental surface, uses described second product to contact described dental surface immediately after.
20. the oral care product including the first container and second container, wherein said first container includes the first compositions, described first compositions comprises the water-insoluble calcium phosphate with the calcium of 1:1 to 10:1 and the mol ratio of phosphorus of by weight 0.01% to 99%, and described second container includes the second compositions, and described second compositions comprises the organic phosphate with following formula of by weight 0.01% to 99%:
Wherein R is the alkyl comprising 4 to 22 carbon atoms；X and Y is each independently the alkylidene comprising 2 to 4 carbon atoms；A and b is each independently the integer of 0 to 20, and a+b is in the scope of 0 to 20；Z1And Z2The alkyl be each independently selected from hydrogen, comprising 1 to 26 carbon and counter ion counterionsl gegenions, precondition is Z1And Z2In at least one be hydrogen or counter ion counterionsl gegenions.
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CA2929053C (en) 2019-01-29

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