CN105722521A - Traditional Chinese medicine composition for treating ulcerative colitis, and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating ulcerative colitis, and preparation method thereof Download PDFInfo
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Abstract
A traditional Chinese medicine composition for treating ulcerative colitis (UC), the composition comprising the following raw materials: 7-11 parts by weight of coptis, 7-11 parts by weight of baked ginger, 7-11 parts by weight of radix sophorae flavescentis, 4-8 parts by weight of notoginseng, 4-11 parts by weight of indigo naturalis, 4-8 parts by weight of costustoot, 7-11 parts by weight of carbonized sanguisorba root and 1-5 parts by weight of honey-fried licorice root. The traditional Chinese medicine composition has a good UC treatment effect, low relapse rate and few side effects, is beneficial to clean the intestinal canal, warm the stomach and tone the spleen, mildly regulate cold and heat, disperse blood stasis and stop bleeding, thus relieving the pain of diseases, improving quality of life, and prolonging life.
Description
A kind of for treating Chinese medicine composition of ulcerative colitis and preparation method thereof technical field, the invention belongs to field of traditional Chinese, and in particular to a kind of to treat Chinese medicine composition of ulcerative colitis and preparation method thereof.
Say
Background technology
Ulcerative colitis（Ulcerative col itis, UC) it is a kind of cause of disease still colon not fully aware of and rectum chronic nonspecific inflammation disease, lesion is confined to colorectal mucosa and submucosa.Being located at sigmoid colon and rectum lesion more, also colon descendens be may extend to, even whole colon, the course of disease is very long, normal recurrent exerbation, can occur at any age, it is more common in book 20-40 Sui, men and women's incidence of disease, without significant difference, is the disease of GI Medicine, the category such as traditional Chinese medical science category " intestines are broken off ", " dysentery ".The clinical manifestation of ulcerative colitis can have many forms, mucopurulent bloody stool is the important behaviour of this sick active stage, other symptoms have stomachache, Nausea and vomiting, weight loss, tenesmus etc., occur together periphery arthritis sometimes, episcleritis, the parenteral performance such as canker sore and cutaneous lesions, Medium or severe type patient activity's phase then has the general manifestations such as heating, anaemia.In most patient this disease show as it is chronic, low pernicious, in a few patients（It is in Acute onset in accounting for 15%), it is accidental acute to break out onset.These patients show as frequently courageous and upright excrement, can up to 30 times/day, and hyperpyrexia, stomachache.Simultaneously, sign is directly related with stadium and clinical manifestation, patient often has weight loss and pale complexion, in disease activity phase abdomen examination, colon site often has tenderness, may have acute abdomen sign occur together heat and gurgling sound reduce, it is particularly evident in acute attack or fulminant type case, can there are abdominal distension, heating and acute abdomen sign during toxic megacolon.Due to frequently suffering from diarrhoea, anal skin can have scratch, strip off.Can also occur crissum inflammation such as anal fissure or anal fistula, although the latter's more common, digital rectal examination sense pain in Crohn's diseases, skin, mucous membrane, tongue, joint and eye inspection it is particularly important.Jin20Nian Lai China IBD, the particularly incidence of disease of ulcerative colitis, illness rate are rough to speculate that UC illness rates are about 11. 6,/10 ten thousand in trend is gradually increased.
In the prior art, minosalicylates, drugs are that the light moderate for the treatment of clinically commonly used at present is burst
The medicine of ulcer colitis, including salicylic acid salicylazosulfapyridine（SASP), 5-aminosalicylic acid (5-ASA), etc., its adverse reaction is more, such as Nausea and vomiting, haemolysis, and to some patientss unsatisfactory curative effect.Glucocorticoid medicine such as Bo Nisonglong, dexamethasone, hydrocortisone etc., only there is preferable effect to short-term relief symptom, it is relatively low to there is bioavilability in some drugs, enteron aisle leaves the defects such as many, and Long-term Hormone class medicine can aggravate or induce infection, tardy, cloudy attacking property adverse reaction relevant with cumulant etc. occurs.In the prior art on many of Ulcerative Colitis Treated with Chinese Drugs, for example《43 observation of curative effect of Chinese medicinal granule Coryza Treated by Syndrome Differentiation ulcerative colitis》In describe Chinese traditional treatment and be typically divided into retention of damp-heat in the interior type, mostly early stage or acute relapse phase by dialectical, with holding purulence band blood under the arm in just, smell dirty smelly, tenesmus, the symptom such as burning sensation of the anus, suitable clearing heat and promoting diuresis, mediation breath, the side based on baitouweng decoction；Qi stagnation and blood stasis type is the patient of chronic relapsing, and, abdomen fixed pain tenderness not well with diarrhea, stool carries mucus or purulence blood, and dim complexion, belch such as eats at the symptom less, and Shixiao San is closed with bupleurum powder for relieving liver-qi；Liver-depression and spleen-insufficiency type is chronic relapsing or sustained patient, and with borborygmus in abdomen, abdominal pain diarrhea subtracts bitterly after letting out, the symptom such as feeling of oppression over the chest and distention of hypochondrium, suitable liver soothing and speen fortifying, relieving QI stagnancy in the stomach, and shenling baizhu powder is closed with tongxieyao formula；Due to weakness of spleen and stomach, chronic sustained type patient, rushes down during with half congealed during stool, has held mucus or indigestion under the arm, and complexion beach wormwood is yellow, and limb is tired powerless, pale tongue with white fur, symptom, suitable strengthening the spleen and replenishing qi, and the stomach dampness removing, the side based on shenling baizhu powder such as arteries and veins is thin and delicate；Yang deficiency of spleen and stomache is chronic sustained type patient, with Diarrhoea, for very from diarrhoea morning, in the afternoon then light soft stools, the symptom such as secret anguish in abdomen, suitable tonifying spleen and kidney, relieving diarrhea with astringents, is closed and is added and subtracted based on Fuzi Lizhong Wan with Sishen wan；Deficiency of YIN-blood type, is chronic sustained type patient, in abdomen secret anguish thin with big loose stool, tidal fever in the afternoon, spiritlessness and weakness, the red few tongue of tongue, suitable replenishing the vital essence and the blood, qi and solidifying intestines, based on shenling baizhu powder conjunction decoction made from radix adenophorea, tuber of dwarf lilyturf.But existing Chinese medicine effect link is still unclear, differentiation of symptoms and signs for classification of syndrome disunity, and Different therapeutical effect is big in existing disclosed document.
The content of the invention
For this, the technical problems to be solved by the invention are that the effect of Medication in Ulcerative Colitis of the prior art is not good, high recurrence rate, side effect substantially, and then provides one kind and treats that ulcerative colitis effect is good and recurrence rate is low and the unconspicuous Chinese medicine composition of side effect and preparation method thereof.
In order to solve the above technical problems, being used to treat in ulcerative colitis the invention provides a kind of
Drug composition, the bulk drug of the composition, which is constituted, is：Coptis 7-11 parts by weight, baked ginger 7-11 parts by weight, kuh-seng 7-11 parts by weight, pseudo-ginseng 4-8 parts by weight, indigo naturalis 4-11 parts by weight, banksia rose 4-8 parts by weight, charred RADIX SANGUISORBAE 7-11 parts by weight and honey-fried licorice root 1-5 parts by weight.The described Chinese medicine composition for being used to treat ulcerative colitis, the bulk drug of the composition, which is constituted, is：The parts by weight of the coptis 9, the parts by weight of baked ginger 9, the parts by weight of kuh-seng 9, the parts by weight of pseudo-ginseng 6, the parts by weight of indigo naturalis 9, the parts by weight of the banksia rose 6, the parts by weight of charred RADIX SANGUISORBAE 9 and the parts by weight of honey-fried licorice root 3；Or
The parts by weight of the coptis 7, the parts by weight of baked ginger 11, the parts by weight of kuh-seng 7, the parts by weight of pseudo-ginseng 8, the parts by weight of indigo naturalis 4, the parts by weight of the banksia rose 8, the parts by weight of charred RADIX SANGUISORBAE 7 and the parts by weight of honey-fried licorice root 5；Or
The parts by weight of the coptis 11, the parts by weight of baked ginger 7, the parts by weight of kuh-seng 7, the parts by weight of pseudo-ginseng 8, the parts by weight of indigo naturalis 11, the parts by weight of the banksia rose 4, the parts by weight of charred RADIX SANGUISORBAE 11 and the parts by weight of honey-fried licorice root 1；Or
The parts by weight of the coptis 8, the parts by weight of baked ginger 10, the parts by weight of kuh-seng 8, the parts by weight of pseudo-ginseng 7, the parts by weight of indigo naturalis 5, the parts by weight of the banksia rose 7, the parts by weight of charred RADIX SANGUISORBAE 10 and the parts by weight of honey-fried licorice root 4；Or
The parts by weight of the coptis 10, the parts by weight of baked ginger 8, the parts by weight of kuh-seng 10, the parts by weight of pseudo-ginseng 5, the parts by weight of indigo naturalis 10, the parts by weight of the banksia rose 5, the parts by weight of charred RADIX SANGUISORBAE 8 and the parts by weight of honey-fried licorice root 2；Or
The parts by weight of the coptis 9, the parts by weight of baked ginger 9, the parts by weight of kuh-seng 9, the parts by weight of pseudo-ginseng 6, the parts by weight of indigo naturalis 8, the parts by weight of the banksia rose 5, the parts by weight of charred RADIX SANGUISORBAE 7 and the parts by weight of honey-fried licorice root 3；Or
The parts by weight of the coptis 8, the parts by weight of baked ginger 7, the parts by weight of kuh-seng 7, the parts by weight of pseudo-ginseng 6, the parts by weight of indigo naturalis 11, the parts by weight of the banksia rose 4, the parts by weight of charred RADIX SANGUISORBAE 11 and the parts by weight of honey-fried licorice root 4；Or
The parts by weight of the coptis 11, the parts by weight of baked ginger 11, the parts by weight of kuh-seng 11, the parts by weight of pseudo-ginseng 8, the parts by weight of indigo naturalis 4, the parts by weight of the banksia rose 4, the parts by weight of charred RADIX SANGUISORBAE 11 and the parts by weight of honey-fried licorice root 5.The described Chinese medicine composition for being used to treat ulcerative colitis, the composition adds customary adjuvant according to common process and the clinically formulation such as acceptable granule, capsule, pill, suppository is made.
A kind of to prepare the above-mentioned method for being used to treat the Chinese medicine composition of ulcerative colitis, this method comprises the following steps：
(a) according to selected parts by weight take the coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose,
Elm charcoal and honey-fried licorice root, are respectively crushed into after fine powder and mix or be ground into fine powder after mixing, cross 100-150 mesh sieves standby；
(b) above-mentioned fine powder is taken, customary adjuvant is added and clinically acceptable granule, capsule, pill, suppository is made according to common process.
The above-mentioned method for being used to treat the Chinese medicine composition of ulcerative colitis also is prepared including another, this method comprises the following steps：
(a) coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root is taken to mix according to selected parts by weight, add water to cook secondary, add the water of 8-12 times of drug weight for the first time, decoct 1.5-2.5 hours, add 6-10 times to measure water for the second time, decoct 1-2 hours, filtration, merging filtrate, stands overnight, and takes the medicinal extract that supernatant concentration is 1.2-1.25 to 60 °C of relative densities；
(b) medicinal extract is taken, customary adjuvant is added and clinically acceptable granule, capsule, pill, suppository is made according to common process.
Further, this method comprises the following steps：
(a) coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root is taken to mix according to selected parts by weight, add water to cook secondary, add the water of 10 times of drug weights for the first time, decoct 2 hours, second plus 8 times of amount water are decocted 1.5 hours, filtration, merging filtrate, stands overnight, and takes the medicinal extract that supernatant concentration is 1.2-1.25 to 60 °C of relative densities；
(b) medicinal extract is taken, customary adjuvant is added and clinically acceptable granule, capsule, pill, suppository is made according to common process.
The above-mentioned method for being used to treat the Chinese medicine composition of ulcerative colitis also is prepared including another, this method comprises the following steps：
The coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root co-grinding are taken into coarse powder according to selected parts by weight, plus the 55-75% ethanol of 4-12 times of drug weight, dipping is after 12-48 hours, it is 30 °C 40 °C that fluid temperature is kept to medicine liquid heating, forced circulation 3-4 hours, filtering, obtains alcohol extract, customary adjuvant is added, clinically acceptable granule, capsule, pill, suppository is made according to common process.
Further, this method comprises the following steps：
The coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root co-grinding are taken into coarse powder according to selected parts by weight, plus 60% ethanol of 8 times of drug weights, dipping is after 30 hours, it is 35 °C that fluid temperature is kept to medicine liquid heating, forced circulation 3. 5 hours, filtering, obtains alcohol extract, customary adjuvant is added, clinically acceptable granule, capsule, pill, suppository is made according to common process.
It is used for the application that ulcerative colitis medicine is treated in preparation the invention also discloses a kind of Chinese medicine composition for being used to treat ulcerative colitis prepared by above-mentioned preparation method, and by above-mentioned Chinese medicine composition.
Applicant is by long-term a large amount of clinical observations and practice, it is believed that the clinic of patients of ulcerative colitis is to suffer from diarrhoea, mucopurulent bloody stool, stomachache, tenesmus is primary symptom, and the interpretation of the cause, onset and process of an illness is insufficiency of the spleen for this, enteron aisle is damp and hot for mark, interpretation of the cause, onset and process of an illness key is cold-heat jumble, and gut purge middle benefit gas is worked as in dampness and heat stasis, treatment, removing blood stasis and hemostasis, mildly regulating cold and heat, formulates Chinese medicine composition of the present invention, and good effect is obtained for treating clinical ulcerative colitis；Chinese medicine composition of the present invention is made up of the coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root, and the coptis, kuh-seng, indigo naturalis, charred RADIX SANGUISORBAE bitter cold enter blood system in side, can gut purge hemostasis；Baked ginger is warm-natured both can be warming spleen and stopping diarrha, again can manufacture-yellow even etc. all medicines bitter cold, mildly regulating cold and heat；Pseudo-ginseng removing blood stasis and hemostasis, the orderly and clearly mechanism of qi of the banksia rose, all medicines share can get that clear sharp enteron aisle is damp and hot, and warming middle-JIAO and strengthening the spleen, mildly regulating cold and heat, effect of removing blood stasis and hemostasis, so as to reach mitigation disease pain, is improved the quality of living, extends the purpose of life span.
The above-mentioned technical proposal of the present invention has advantages below compared with prior art：
(1) the traditional Chinese medicine composition for treating effect of the present invention for being used to treat ulcerative colitis is good, warming middle-JIAO and strengthening the spleen damp and hot with clear sharp enteron aisle, mildly regulating cold and heat, the effect of removing blood stasis and hemostasis, so as to reach mitigation disease pain, improve the quality of living, extend the purpose of life span；
(2) Chinese medicine composition of the present invention for being used to treat ulcerative colitis is compared with existing medicine SASP enteric coatel tablets, the two disease activity index（Desease activity index, DAI) horizontal no significant difference；For Colonic Mucosa of The Rat damage index, the Chinese medicine composition of the present invention is used
Experimental colitis rat colon and surrounding tissue adhesion it is lighter, colon surface has no the inflammatory pseudomembrane of bronzing, congested, oedema mitigates, with colonic mucosal injury index (conlonic mucosa damage index, CMDI) horizontal no significant difference of existing medicine SASP enteric coatel tablets；Each dosage group colon histological scores of the invention are significantly lower than model group P ＜ 0. 05, wherein QCWZD of the present invention is high, QCWZD middle dose group inflammatory cells invade the degree of profit significantly lower than model group；05) rat blood serum IL-6, TNF- alpha levels be decreased obviously P ＜ 0. compared with model group, and with the horizontal no significant difference of blank group；
(3) preparation method of the present invention for being used to treat the Chinese medicine composition of ulcerative colitis, the Chinese medicine composition of the clinically formulation such as acceptable granule, capsule, pill, suppository is obtained by this method, easily facilitate take, preserve, stability it is good, safe.
Following experimental examples are to prove the technique effect of pharmaceutical composition of the present invention.
Experimental example 1
Purposes of the present invention in terms of ulcerative colitis is treated is better described below by way of basic test example.The Chinese medicine composition of the present invention is compared with control group, it was demonstrated that the effect of traditional Chinese medicine composition for treating ulcerative colitis of the invention is notable.
1. experiment material
Experimental animal：Healthy SD rat, male 35,200 ± 20g of body weight, SPF grades of rank.Experimental agents：The medicine of test group is the Chinese medicine composition prepared in the present embodiment 1, and each dosage is crude drug amount 1200mg/kg by mouse body weight, crude drug amount 600mg/kg, crude drug amount 300mg/kg are divided into QCWZD height, QCWZD, QCWZD low dosage test groups；Control group is that SASP groups, i.e. medicine are SASP enteric coatel tablets, and each dosage is 400mg/kg by body weight.
Medication：Gavage.
2. experimental method and result：
2. 1 test method
200 ± 20g of body weight is taken, healthy SD rat 35, male is randomly divided into six groups：Blank group is
The SD rats of health, pour into 0. 6ml deionized water；Remaining each group carries out the experimental colitis rat model of modeling, the as induction of TNBS/ ethanol bowel lavage according to the modeling method in existing literature：SD Rat Fasts can't help water 24h, 10% chloraldurate before modeling（0. 3ml/100g) intraperitoneal injection of anesthesia rat, rectum about 8cm slowly will gently be inserted by anus after latex flexible pipe lubrication of liquid paraffin, disposably slowly inject the 6ml of TNBS solution (100mg/kg) 0. containing 33. 3% ethanol, completed within lmin, keep the upward 15min of dorsal position buttocks, naturally put back to after reviving in cage, conventional word is supported, take 5 rats to be separated after putting to death after 3 days immediately and check colon, there is obvious colonic mucosal injury, point out modeling success.
Medication：Blank group and model group give the physiological saline of lOml/kg mouse body weight；Control group, dosage is 400mg/kg mouse body weight；The high, medium and low dosage groups of QCWZD are that Chinese medicine composition prepared by the embodiment of the present invention 1 is divided into high, medium and low amount group by dosage, and each dosage is respectively crude drug amount 1200mg/kg mouse body weight, crude drug amount 600mg/kg mouse body weight, crude drug amount 300mg/kg mouse body weight.Each equal gastric infusion of administration group, one time a day, is used in conjunction 10 days.
2. 2 result of the tests
2. 2. the observation of the curative effect of the experimental colitis rat of 1 pair of TNBS induction
2. 2. the experimental colitis rat DAI of 1. 1 pairs of TNBS inductions influence
The 2nd day after modeling, model group rats are suffered from diarrhoea, and are yellow loose stools, half loose stools even bloody stool, and now rat hair color tarnishes, and activity is poor, delay of response, lazy move, and maximum is reached to the 3rd day DAI.(DAY7) each medication group rat spirit takes a turn for the better after medication 4 days, hair color is gradually glossy, appetite increase, activity gradually increases, stool is gradually normal, DAI is decreased obviously Ο), the recovery of medication 5 days (DAY8) to 10 days (DAY13) DAI of medication is more slow, and each group DAI degree DAY13 and DAY7 is without significant difference Ρ>0· 05.Blank group rat then changes without above-mentioned spirit, activity, hair color etc., such as table 1.After pharmaceutical intervention 10 days, model group DAI is still significantly higher than blank group (P<0. 05), and SASP groups and each dosage group of the invention significantly decrease (Ρ ＜ 0. 05) compared with model group, and QCWZD senior middle schools low dose group DAI levels of the present invention are compared with SASP group（Salazosulfapyridine, SASP) organize no significant difference P ＞ 0. 05), such as table 2.
The DAI diurnal variation tables of table 1.
The model group 0.00 ± 0 00 1.53 ± 0 39 0.90 ± 0 75 of 13 blank groups of g DAY1 DAY3 DAY7 DAY 0.00 ± 0 00 0.00 ± 0 00 0.00 ± 0 00 0.00 ± 0 00a 0.95 ±0· 49ad
SASP groups 0.00 ± 0 00 1.83 ± 0 39 0.67 ± 0 54a 0.42 ±0.35ad
The high agent 1 of QCWZD：Group 0.00 ± 0 00 1.37 ± 0 56 0.57 ± 0 32a 0.50 ±0.25ad
Agent 1 in QCWZD：Group 0.00 ± 0 00 2.10 ± 0 47 0.53 ± 0 61a 0.45 ±0.47ad
Low dose 1 of QCWZD：Group 0.00 ± 0 00 2.13 ± 0 45 0.47 ± 0.39a 0.46 ±0.31adNote： Ρ〈0.05,hP>0.05 is compared with DAY3；CP<0.05, &Ρ ＞ 0 05 are compared with DAY7.
2.2.1.2 Colonic Mucosa of The Rat damage index
The visible colonic mucosa erosion weight of model group naked eyes, ulcer is compared with depth and area is larger, has obvious intestinal contents to be embedded at ulcer, is difficult to rinse；It can be seen that obvious oedema, congested, colon surface is covered with the inflammatory pseudomembrane of bronzing；Enteric cavity dilatating and deformable at colonic pathological change；Lesion colon substantially, is not readily separated with surrounding tissue adhesion.Each medication group colon and surrounding tissue adhesion are lighter, and colon surface has no the inflammatory pseudomembrane of bronzing, and congested, oedema mitigates, and ulcer is in healing sex expression.After medication 10 days, model group colonic mucosal injury index（Colonic mucosa damage index, CMDI) it is still significantly higher than blank group { P<° 05) 0.05), SASP groups and QCWZD middle dose groups of the present invention are decreased obviously compared with model group, this horizontal no significant difference Ρ of two groups of CMDI>0.05, such as table 2.
The model group 6 3.33 ± 0 82 of influence g n CMDI DAI blank groups 5 0.20 ± 0.45 0.07 ± 0 15 for Colitis rat CMDI, DAI that the medicine of table 2. is induced TNBSe 0.95 ±0· 49e
SASP groups 6 2.44 ± 0 73g 0.48 ±0.35g
The high agent 1 of QCWZD：Group 6 2.50 ± 1 22 0.50 ± 0.25
Agent 1 in QCWZD：Group 6 2.25 ± 0.89gh 0.45 ±0.27gh
Low dose 1 of QCWZD：6 3.00 ± 0 00 0.46 ± 0.31 notes of group：eP〈0.05, fP>0. is compared with blank group；gP<0. is compared with model group； P>0.05 is compared with SASP groups.
2.2.1.3 rat colon HS
Visible mucous membrane is congested under model group light microscopic, oedema, massive inflammatory cells infiltrated, is invaded with lymphocyte and neutrophil leucocyte based on profit, and injured depth is up to submucosa, muscle layer even placenta percreta；Goblet cell is significantly reduced, ulcer peripheral part Glandular Dilatation, body of gland arrangement disorder, hyperplasia that glandular epithelium is slight, partly with body of gland atypical hyperplasia, it is seen that inflammatory granuloma.Visible hyperemia, oedema mitigate under each medication group light microscopic, inflammatory cell is invaded profit and mitigated, based on lymphocyte, thick liquid cell, neutrophil leucocyte is rare, the visible eosinophil of indivedual colons, inflammatory cell is invaded profit level and shoaled, and concentrates on submucosa, the Colitis rat colon pathology figure of such as Fig. 1 high, medium and low dosage treatment TNBS inductions of QCWZD（X 40) (note:A- blank groups, B- model groups, C-SASP groups, D-QCWZD high dose groups, E-QCWZD middle dose groups, F-QCWZD low dose groups）.Model group colon histological scores are apparently higher than blank group Ρ ＜ 0.05, and each dosage group colon histological scores of the invention are significantly lower than model group (Ρ<0.), wherein QCWZD of the present invention is high, QCWZD middle dose group inflammatory cells invade profit（Inflammatory infiltration, II) degree significantly lower than model group P ＜ 0.05, such as table 3.
The influence for the Colitis rat HS that the medicine of table 3. is induced TNBS
II HS
The model group 6 1.33 ± 0 82 7.33 ± 0 82 of blank group 5 0.00 ± 0 00 1.11 ± 1., 05e
SASP groups 6 1.17 ± 1 03 5.92 ± 2., 15
The high agent i of QCWZD：Group 6 0.33 ± 0 71g 5.00±L 50g
Agent i in QCWZD：Group 6 0.27 ± 0 46g 3.17±L 40g
Low dose of i of QCWZD：Group 6 0.93 ± 0.96 5.20+2. 40gNote：eP<0.05, fP>0. is compared with blank group；eP<0. is compared with model group.
2.2.2 rat blood serum inflammatory factor TNF- α, the influence of IL- 6
Model group Colitis rat blood serum IL-6, TNF- alpha levels are obviously higher than blank group（ ¾ 05)；SASP group rat blood serum IL-6, TNF- alpha levels are decreased obviously P ＜ 0.05 compared with model group, and with the horizontal no significant difference of blank group（3^.05)；QCWZD of the present invention is high, QCWZD middle dose group TNF- alpha levels are decreased obviously Ρ ＜ 0.05 compared with model group), with blank group no significant difference Ρ ＞ 0.05)；QCWZD low dose groups IL-6 is decreased obviously P compared with model group<0.05), with blank group and notable difference
Ρ ＞ 0 05), such as table 4.
Colitis rat blood serum IL-6 that the medicine of table 4. is induced TNBS, the TNF- α model group 6 162.52 ± 32 06 of influence g n IL-6 TNF-αs blank group 5 112.01 ± 6 53 63.92 ± 7 53e 78.98 ±1.78e
The ll of SASP groups 6 123.90 ± 30fg 64.63 ±8· 90fg
The high agent i t groups 6 135.16 ± 12 75 67.53 ± 4 59 of QCWZDfg
Agent i t groups 6 142.15 ± 7 09 67.79 ± 6.48 in QCWZDfg
Low dose of i t group 6 114.75 ± 18.43 of QCWZDfg70.20 ± 7.82 notes：β, ^ β are compared with blank group；Ftft^ is compared with model group.3. conclusion
(1) Chinese medicine composition of the invention has protective effect to the Colitis rat intestinal mucosa that TNBS is induced, and can effectively improve colon's inflammatory cell and invade profit；
(2) Chinese medicine composition of the invention can play a part of anti-inflammatory by lowering blood serum IL-6, TNF-α level to the TNBS Colitis rats induced.
Brief description of the drawings
In order that present disclosure is more likely to be clearly understood, below according to specific embodiment of the invention and with reference to accompanying drawing, the present invention is further detailed explanation, wherein
Fig. 1 is the Colitis rat colon pathology figure of traditional Chinese medicine composition for treating TNBS inductions prepared by the embodiment of the present invention 1（X40).
Embodiment
The bead dosage form of embodiment 1
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis 7g, baked ginger llg, kuh-seng 7g, pseudo-ginseng 8g, indigo naturalis 4g, banksia rose 8g, charred RADIX SANGUISORBAE 7g and honey-fried licorice root 5g.The Chinese medicine composition is prepared into granule according to following steps：
(a) coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root is taken to mix according to selected parts by weight, add water to cook secondary, add 570ml water for the first time, decoct 1.5 hours, second plus 456ml of water is decocted 1 hour, filtration, merging filtrate, stands overnight, and takes the medicinal extract that supernatant concentration is 1.2-1.25 to 60 °C of relative densities；
(b) medicinal extract is taken, clinically acceptable granule is made in the customary adjuvant added according to common process in pharmacy.
The capsule formulation of embodiment 2
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis l lg, baked ginger 7g, kuh-seng 7g, pseudo-ginseng 8g, indigo naturalis l lg, banksia rose 4g, charred RADIX SANGUISORBAE 11 and honey-fried licorice root lg.
The Chinese medicine composition is prepared into granule according to following steps：
(a) coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, ^ fragrant, charred RADIX SANGUISORBAE and honey-fried licorice root is taken to mix according to the bulk drug of above-mentioned selected weight, add water to cook secondary, the decocting of 12 times of drug weights is added to boil 2 hours for the first time, second plus 10 times of drug weight water, decoct 1.5 hours, filtration, merging filtrate, strive and put overnight, take the medicinal extract that supernatant concentration is 1.2-1.25 to 60 °C of relative densities；
(b) medicinal extract is taken, clinic is made in the customary adjuvant added according to common process in pharmacy " " the capsule received.
The pill-type of embodiment 3
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis 9g, baked ginger 9g, kuh-seng 9g, pseudo-ginseng 6g, indigo naturalis 9g, banksia rose 6g, the honey-fried licorice root 3g of charred RADIX SANGUISORBAE 9.
The Chinese medicine composition is prepared into pill according to following steps：
(a) according to the bulk drug of above-mentioned selected weight, take the coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis ^ fragrant, charred RADIX SANGUISORBAE and honey-fried licorice root mixing, add water to cook secondary, add the water of 8 times of drug weights for the first time, H is boiled 1.5 hours, second plus 6 times of drug weight water, is decocted 2 hours, filtration, merging filtrate
Stand overnight, take the medicinal extract that supernatant concentration is 1.2-1.25 to 60 °C of relative densities；
(b) medicinal extract is taken, the customary adjuvant added according to common process in pharmacy, pill is dried, selects ball, packs, clinically acceptable pill is made.
The suppository type of embodiment 4
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis 8g, baked ginger 10g, kuh-seng 8g, pseudo-ginseng 7g, indigo naturalis 5g, banksia rose 7g, charred RADIX SANGUISORBAE 10g and honey-fried licorice root 4g.
The Chinese medicine composition is prepared into suppository according to following steps：
(a) according to the bulk drug of above-mentioned selected weight, take the coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root mixing, secondary, the water of first time plus 10 times of drug weights is added water to cook, is decocted 2.5 hours, second plus 8 times of drug weight water, decoct 1.5 hours, filtration, merging filtrate, stand overnight, take the medicinal extract that supernatant concentration is 1.2-1.25 to 60 °C of relative densities；
(b) medicinal extract is taken, clinically acceptable suppository is made in the customary adjuvant added according to common process in pharmacy.
The bead dosage form of embodiment 5
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis 7g, baked ginger l lg, kuh-seng 7g, pseudo-ginseng 8g, indigo naturalis 4g, banksia rose 8g, charred RADIX SANGUISORBAE 7g and honey-fried licorice root 5g.
The Chinese medicine composition is prepared into granule according to following steps：
(a) coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root are taken according to selected parts by weight, is respectively crushed into after fine powder and mixes or be ground into fine powder after mixing, cross 120 mesh sieves standby；
(b) above-mentioned fine powder is taken, customary adjuvant is added and clinically acceptable granule is made according to common process.
The capsule formulation of embodiment 6
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：Coptis l lg, baked ginger 7g, kuh-seng 7g, pseudo-ginseng 8g, indigo naturalis l lg, banksia rose 4g, charred RADIX SANGUISORBAE l lg and honey-fried licorice root lg.
The Chinese medicine composition is prepared into capsule according to following steps：
The coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root co-grinding are taken into coarse powder according to selected parts by weight, plus 360ml 75% ethanol, dipping is after 12 hours, it is 30 °C 40 °C that fluid temperature is kept to medicine liquid heating, forced circulation 3. 5 hours, filtering, obtains alcohol extract, customary adjuvant is added, clinically acceptable capsule is made according to common process.
The pill-type of embodiment 7
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis 9g, baked ginger 9g, kuh-seng 9g, pseudo-ginseng 6g, indigo naturalis 9g, banksia rose 6g, charred RADIX SANGUISORBAE 9g and honey-fried licorice root 3g.
The Chinese medicine composition adds pharmaceutically customary adjuvant according to common process and pill is made.
The Chinese medicine composition of the treatment ulcerative colitis of the suppository type the present embodiment of embodiment 8, its formula is as follows：
Coptis 8g, baked ginger 10g, kuh-seng 8g, pseudo-ginseng 7g, indigo naturalis 5g, banksia rose 7g, charred RADIX SANGUISORBAE 10g and honey-fried licorice root 4g.
The Chinese medicine composition adds pharmaceutically customary adjuvant according to common process and suppository is made.
The granule of embodiment 9
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis 10g, baked ginger 8g, kuh-seng 10g, pseudo-ginseng 5g, indigo naturalis 10g, banksia rose 5g, charred RADIX SANGUISORBAE
8g and honey-fried licorice root 2g.The Chinese medicine composition adds pharmaceutically customary adjuvant according to common process and granule is made.
The capsule of embodiment 10
The Chinese medicine composition of the treatment treatment ulcerative colitis of the present embodiment, its formula is as follows：Coptis 9g, baked ginger 9g, kuh-seng 9g, pseudo-ginseng 6g, indigo naturalis 8g, banksia rose 5g, charred RADIX SANGUISORBAE 7g and honey-fried licorice root 3g.
The Chinese medicine composition adds pharmaceutically customary adjuvant according to common process and capsule is made.
The pill of embodiment 11
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis 8g, baked ginger 7g, kuh-seng 7g, pseudo-ginseng 6g, indigo naturalis l lg, banksia rose 4g, charred RADIX SANGUISORBAE l lg and honey-fried licorice root 4g.
The Chinese medicine composition adds pharmaceutically customary adjuvant according to common process and pill is made.
The suppository of embodiment 12
The Chinese medicine composition of the treatment ulcerative colitis of the present embodiment, its formula is as follows：
Coptis l lg, baked ginger l lg, kuh-seng l lg, pseudo-ginseng 8g, indigo naturalis 4g, banksia rose 4g, charred RADIX SANGUISORBAE l lg and honey-fried licorice root 5g.
The Chinese medicine composition adds pharmaceutically customary adjuvant according to common process and suppository is made.
Obviously, above-described embodiment is only intended to clearly illustrate example, and the not restriction to embodiment.For those of ordinary skill in the field, it can also make other changes in different forms on the basis of the above description.There is no necessity and possibility to exhaust all the enbodiments.And among the obvious changes or variations thus extended out is still in the protection domain of the invention
Claims (1)
- Claims1. a kind of Chinese medicine composition for being used to treat ulcerative colitis, it is characterised in that the bulk drug of the composition, which is constituted, is：Coptis 7-11 parts by weight, baked ginger 7-11 parts by weight, kuh-seng 7-11 parts by weight, pseudo-ginseng 4-8 parts by weight, indigo naturalis 4-11 parts by weight, banksia rose 4-8 parts by weight, charred RADIX SANGUISORBAE 7-11 parts by weight and honey-fried licorice root 1-5 parts by weight.2. it is used for the Chinese medicine composition for treating ulcerative colitis according to claim 1, it is characterised in that the bulk drug of the composition, which is constituted, is：The parts by weight of the coptis 9, the parts by weight of baked ginger 9, the parts by weight of kuh-seng 9, the parts by weight of pseudo-ginseng 6, the parts by weight of indigo naturalis 9, the parts by weight of the banksia rose 6, the parts by weight of charred RADIX SANGUISORBAE 9 and the parts by weight of honey-fried licorice root 3；OrThe parts by weight of the coptis 7, the parts by weight of baked ginger 11, the parts by weight of kuh-seng 7, the parts by weight of pseudo-ginseng 8, the parts by weight of indigo naturalis 4, the parts by weight of the banksia rose 8, the parts by weight of charred RADIX SANGUISORBAE 7 and the parts by weight of honey-fried licorice root 5；OrThe parts by weight of the coptis 11, the parts by weight of baked ginger 7, the parts by weight of kuh-seng 7, the parts by weight of pseudo-ginseng 8, the parts by weight of indigo naturalis 11, the parts by weight of the banksia rose 4, the parts by weight of charred RADIX SANGUISORBAE 11 and the parts by weight of honey-fried licorice root 1；OrThe parts by weight of the coptis 8, the parts by weight of baked ginger 10, the parts by weight of kuh-seng 8, the parts by weight of pseudo-ginseng 7, the parts by weight of indigo naturalis 5, the parts by weight of the banksia rose 7, the parts by weight of charred RADIX SANGUISORBAE 10 and the parts by weight of honey-fried licorice root 4；OrThe parts by weight of the coptis 10, the parts by weight of baked ginger 8, the parts by weight of kuh-seng 10, the parts by weight of pseudo-ginseng 5, the parts by weight of indigo naturalis 10, the parts by weight of the banksia rose 5, the parts by weight of charred RADIX SANGUISORBAE 8 and the parts by weight of honey-fried licorice root 2；OrThe parts by weight of the coptis 9, the parts by weight of baked ginger 9, the parts by weight of kuh-seng 9, the parts by weight of pseudo-ginseng 6, the parts by weight of indigo naturalis 8, the parts by weight of the banksia rose 5, the parts by weight of charred RADIX SANGUISORBAE 7 and the parts by weight of honey-fried licorice root 3；OrThe parts by weight of the coptis 8, the parts by weight of baked ginger 7, the parts by weight of kuh-seng 7, the parts by weight of pseudo-ginseng 6, the parts by weight of indigo naturalis 11, the parts by weight of the banksia rose 4, the parts by weight of charred RADIX SANGUISORBAE 11 and the parts by weight of honey-fried licorice root 4；OrThe parts by weight of the coptis 11, the parts by weight of baked ginger 11, the parts by weight of kuh-seng 11, the parts by weight of pseudo-ginseng 8, the parts by weight of indigo naturalis 4, the parts by weight of the banksia rose 4, the parts by weight of charred RADIX SANGUISORBAE 11 and the parts by weight of honey-fried licorice root 5.3. the Chinese medicine composition according to claim 1 or claim 2 for being used to treat ulcerative colitis, it is characterised in that the Chinese medicine composition is made clinically acceptable according to common process addition customary adjuvant Granule, capsule, pill, suppository.4. a kind of prepare the method for being used to treat the Chinese medicine composition of ulcerative colitis as described in claim 1-3 is any, it is characterised in that this method comprises the following steps：(a) coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root are taken according to selected parts by weight, is respectively crushed into after fine powder and mixes or be ground into fine powder after mixing, cross 100-150 mesh sieves standby；(b) above-mentioned fine powder is taken, customary adjuvant is added and clinically acceptable granule, capsule, pill, suppository is made according to common process.5. a kind of prepare the method for being used to treat the Chinese medicine composition of ulcerative colitis as described in claim 1-3 is any, it is characterised in that this method comprises the following steps：(a) coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root is taken to mix according to selected parts by weight, add water to cook secondary, add the water of 8-12 times of drug weight for the first time, decoct 1.5-2.5 hours, add 6-10 times to measure water for the second time, decoct 1-2 hours, filtration, merging filtrate, stands overnight, and takes the medicinal extract that supernatant concentration is 1.2-1.25 to 60 °C of relative densities；(b) medicinal extract is taken, customary adjuvant is added and clinically acceptable granule, capsule, pill, suppository is made according to common process.6. method according to claim 5, it is characterised in that this method comprises the following steps：(a) coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root is taken to mix according to selected parts by weight, add water to cook secondary, add the water of 10 times of drug weights for the first time, decoct 2 hours, second plus 8 times of amount water are decocted 1.5 hours, filtration, merging filtrate, stands overnight, and takes the medicinal extract that supernatant concentration is 1.2-1.25 to 60 °C of relative densities；(b) medicinal extract is taken, customary adjuvant is added and clinically acceptable granule, capsule, pill, suppository is made according to common process.7. a kind of prepare the method for being used to treat the Chinese medicine composition of ulcerative colitis as described in claim 1-3 is any, it is characterised in that this method comprises the following steps：According to selected parts by weight take the coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and Honey-fried licorice root co-grinding is into coarse powder, plus the 55-75% ethanol of 4-12 times of drug weight, dipping is after 12-48 hours, it is 30 °C 40 °C that fluid temperature is kept to medicine liquid heating, forced circulation 3-4 hours, filtering, obtains alcohol extract, customary adjuvant is added, clinically acceptable granule, capsule, pill, suppository is made according to common process.8. method according to claim 7, it is characterised in that this method comprises the following steps：The coptis, baked ginger, kuh-seng, pseudo-ginseng, indigo naturalis, the banksia rose, charred RADIX SANGUISORBAE and honey-fried licorice root co-grinding are taken into coarse powder according to selected parts by weight, plus 60% ethanol of 8 times of drug weights, dipping is after 30 hours, it is 35 °C that fluid temperature is kept to medicine liquid heating, forced circulation 3. 5 hours, filtering, obtains alcohol extract, customary adjuvant is added, clinically acceptable granule, capsule, pill, suppository is made according to common process.9. the Chinese medicine composition prepared according to any described methods of claim 4-9.10. the Chinese medicine composition according to claim 1 or 2 or 3 or 9 is used for the application for preparing treatment ulcerative colitis medicine.
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