CN105707093B - - 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol are applied in insecticide is prepared - Google Patents
- 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol are applied in insecticide is prepared Download PDFInfo
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- CN105707093B CN105707093B CN201610040549.2A CN201610040549A CN105707093B CN 105707093 B CN105707093 B CN 105707093B CN 201610040549 A CN201610040549 A CN 201610040549A CN 105707093 B CN105707093 B CN 105707093B
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- alkene
- glycol
- insecticide
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- wool steroid
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to 9,19 25 alkene of ring wool steroid, 3 β, the application process of 24 glycol is applied in insecticide is prepared, the insecticide significant effect that is prepared using this method, environmental-friendly.
Description
Technical field
The present invention relates to field of pesticides, especially natural insecticide technical field.
Background technology
Pesticide plays highly important effect in agricultural production.Invention the 1940s organic chemical pesticides it
Afterwards, the ability that the mankind control disease pest harm is significantly enhanced, crop yield loss is retrieved for us and has made great tribute
It offers.But long-term rely on uses Synthetic Organic Chemistry pesticide with a large amount of, has had resulted in well-known environmental pollution, ecology
A series of problems, such as balance destruction and food security, to agricultural economy is promoted to realize, sustainable development brings many detrimental effects.
With the raising of people's health consciousness, China is a large agricultural country.Most countries all pay much attention to agricultural product
Security, it is very stringent to the limitation of pesticide residue.After accession to WTO, agricultural product entrance is faced with very severe for China
Green barrier " wherein pesticide residue is exceeded is to frequently encounter problem, seriously affected agricultural products in China in the competing of international market
Strive power.In order to reduce persticide residue, make great efforts exploitation novel agrochemical and have become the task of top priority.
Botanical pesticide is also known as botanical pesticide.Utilize the pesticide of plant resource explorations.
Including extracted from plant active ingredient, plant in itself and by active structure synthesis compound and derivative.
Classification has phytotoxin, plant endogenous hormones, botanical insect hormone, anti-feedant, attractant, repellant, chemosterilant, synergy
Agent, plant defense element, allelopathic substances etc..
By effective ingredient, chemical constitution and purpose classification：Alkaloid, terpenes, flavonoids, essential oil class, light-activated toxin.
Botanical pesticide is an important component of biological pesticide.It refers to some positions using plant（Root, stem, leaf, Hua Huo
Fruit）The active ingredient of contained stabilization, after carrying out use to recipient plant by certain method, make its exempt from or mitigate disease,
The plant source preparation that the harmful organisms such as worm, weeds are caused harm.The plant resources that botanical pesticide is utilized is poisonous plant.So
It is " pesticide made of Chinese medicinal herbs " that botanical pesticide is again popular.
- 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol (9,19-Cycloart-25-ene-3 β, 24-diol)
CAS:10388-48-4
Molecular formula：C30H50O2
Molecular weight：442.73
Structural formula is as follows：
In the prior art, there is no on -3 β of 9,19- ring wool steroid -25- alkene, 24- glycol has the report of insecticidal activity
Road.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of -3 β of 9,19- rings wool steroid -25- alkene, and 24- glycol is answered
With method, i.e. be used as prepare insecticide.
In order to solve the above-mentioned technical problem, the present invention proposes following technical proposal：
- 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol are applied in insecticide is prepared.
Preferably, -3 β of 9,19- rings wool steroid -25- alkene, 24- glycol should in insecticide is prepared as sole active agent
With.
The insecticide can kill mythimna separata, black peach aphid, Brown Planthopper.
Conventional dosage form can be made in the insecticide.
The dosage form can be aqua or pulvis.
Beneficial effects of the present invention can be proved by following experiment
- 3 β of test example 19,19- ring wool steroid -25- alkene, 24- glycol measure the contact toxicity of target worm
（1）Test medicine
- 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol, purity >=99.0%.
（2）Test target
Mythimna separata（Mythimna sepatara）, black peach aphid（Myzus persicae）, Brown Planthopper（Nilaparvata
lugens）.More than worm kind for many generations raises worm kind throughout the year to be indoor.
（3）Instrument and equipment
Electronic analytical balance, culture dish, liquid-transfering gun, card punch, writing brush etc..
（4）Drug solution preparing
The active compound of certain mass is weighed with assay balance, dissolved with DMF and is configured to 1% mother liquor.Measure a certain amount of mother
Liquid adds the liquid for being configured to measure required concentration containing the dilution of 0.1% Tween-80 distilled water, spare.
（5）Test method
A, mythimna separata is screened --- leaf dipping method
It dries in the shade naturally after the maize leaves section sheared in right amount is fully infiltrated in the liquid prepared, is put into the training for being lined with filter paper
It supports in ware, connects mythimna separata 3 age mid-term larva, 10/ware, capping mark, which is placed on, is placed in 24-26 DEG C, the observation of 14h illumination
Indoor culture, investigation result after 2d.Using 0.1% tween water as blank control.Polypide is touched with writing brush, it is reactionless to be considered as extremely
Worm.
B, black peach aphid is screened --- spray-on process
Broad Bean Leaves are broken into leaf dish, the back side is placed on fritter cotton, is placed in plastic culture dish upward, adds a small amount of water,
Connect black peach aphid mixed population.After test worm is stablized on blade, leaf dish is placed under Potter spray towers quantitative（2.5mL）Spraying
Processing（Pressure is 5lb/in2）, experiment sets the tween water of the organic solvent containing maximum concentration as blank control, after naturally dry
It is placed in observation ward and raises and observe.Inspection result after 48 h.Polypide is touched with writing brush, it is reactionless to be considered as dead worm.
C, brown paddy plant hopper is screened --- spray-on process
Using Potter spray-on processes.I.e. by the rice seedling of 4~6 2 leaf, 1 hearts（It is about 3~4cm）Use crystobalite
Sand is fixed in the culture dish of Φ 7cm, and after Brown Planthopper 3 age mid-term nymph is anaesthetized with CO2,30~40 are connect per ware
Head is placed under Potter spray towers quantitative（2.5mL）Spraying treatment（Pressure is 5lb/in2）, test and set containing maximum concentration
The tween water of organic solvent is blank control, is covered after spraying with transparent plastic cup, is placed in 27 DEG C, in the observation ward of 14h illumination
It cultivates, investigation result after 3d.Polypide is touched with writing brush, it is reactionless to be considered as dead worm.
The dead borer population of each processing and borer population living are counted, calculates the death rate.
（6）Result of the test
Result of the test is shown in Table 1, the results showed that, -3 β of 9,19- ring wool steroid -25- alkene, 24- glycol is lived with good desinsection
Property.
Table 1 tests experiment target target insecticidal activity
According to different objects of killing, -3 β of 9,19- ring wool steroid -25- alkene, the effective concentration that 24- glycol kills pest can
So that 1.0-500mg/L.
In use, according to circumstances, conventional method may be employed by -3 β of 9,19- ring wool steroid -25- alkene, 24- glycol is made
Regular dosage form.
In order to preferably illustrate technical scheme, the present invention is made With reference to embodiment further
Illustrate, but protection domain of the presently claimed invention is not limited to the following example.
Specific embodiment
Embodiment 1
Take -3 β of 9,19- ring wool steroid -25- alkene, 24- glycol, by 1:100 mass ratio adds in dextrin, is uniformly mixed, i.e.,
Obtain -3 β of 9,19- ring wool steroid -25- alkene, 24- glycol insecticidal dusts.
Embodiment 2
Take -3 β of 9,19- ring wool steroid -25- alkene, 24- glycol, dissolved with DMF and be configured to 1% solution to get
- 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol aqueous solution of insecticide.
Claims (1)
- - 3 β of 1.9,19- ring wool steroid -25- alkene, 24- glycol are applied in insecticide is prepared, it is characterised in that the insecticide Mythimna separata, black peach aphid, Brown Planthopper can be killed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610040549.2A CN105707093B (en) | 2016-01-21 | 2016-01-21 | - 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol are applied in insecticide is prepared |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610040549.2A CN105707093B (en) | 2016-01-21 | 2016-01-21 | - 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol are applied in insecticide is prepared |
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| Publication Number | Publication Date |
|---|---|
| CN105707093A CN105707093A (en) | 2016-06-29 |
| CN105707093B true CN105707093B (en) | 2018-05-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610040549.2A Active CN105707093B (en) | 2016-01-21 | 2016-01-21 | - 3 β of 9,19- ring wool steroid -25- alkene, 24- glycol are applied in insecticide is prepared |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8715748B2 (en) * | 2012-06-05 | 2014-05-06 | Henry Lowe | Methods for inhibiting prostate cancer by kinases and angiogenesis inhibitory mechanisms of ball moss extract |
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2016
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| CN105707093A (en) | 2016-06-29 |
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Effective date of registration: 20180411 Address after: 211225, Jiangsu Nanjing District Lishui Baima town industrial concentration area Applicant after: NANJING ZELANG BIOTECHNOLOGY CO., LTD. Address before: No. 2 Taishan Road, Jiangsu science and Technology Park, 215000 Canton City of Suzhou province high tech Zone 2-104 Applicant before: Suzhou Paiteng Biopharmaceutical Technology Co., Ltd. |
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Effective date of registration: 20201015 Address after: No.76 Minfeng South Road, Nanfeng Town, Zhangjiagang City, Suzhou City, Jiangsu Province Patentee after: ZHANGJIAGANG DONGDA INDUSTRIAL TECHNOLOGY Research Institute Address before: 211225, Jiangsu Nanjing District Lishui Baima town industrial concentration area Patentee before: NANJING ZELANG BIOTECHNOLOGY Co.,Ltd. |