CN105685027A

CN105685027A - Preparation technology of novel water dispersible granules

Info

Publication number: CN105685027A
Application number: CN201610161960.5A
Authority: CN
Inventors: 吴吉龙; 邹勇; 谢石发; 彭述明; 陈军; 王敏
Original assignee: Hu'nan Agricultural University Heartale Agrochemicals Co Ltd
Current assignee: Hu'nan Agricultural University Heartale Agrochemicals Co Ltd
Priority date: 2016-03-21
Filing date: 2016-03-21
Publication date: 2016-06-22

Abstract

The invention relates to a preparation technology of novel water dispersible granules. The novel water dispersible granules are prepared from the following raw materials: pesticide active ingredients, a wetting agent, a dispersing agent, a disintegrating agent and filler, wherein the percents of the raw materials are as follows: 1-60% of technical materials of the pesticide active ingredients, 0.5-5% of the wetting agent, 2-10% of the dispersing agent, 1-40% of the disintegrating agent, 1-10% of a binding agent and the balance of a carrier. The preparation technology of the novel water dispersible granules is quite different from the traditional fluidized-bed granulation technology and extrusion granulation technology, and is realized in a way of enabling the carrier to be wrapped with powder, namely, the preparation technology of the novel water dispersible granules comprises the steps mixing the technical materials, the wetting agent, the dispersing agent, a stabilizer and the disintegrating agent, and then enabling the mixture to pass through a jet mill to obtain the needed powder; selecting soluble granular inorganic salt or organic material as the carrier, and enabling the soluble carrier to be evenly wrapped with the obtained powder by a certain amount of the binding agent. The preparation technology has the advantages of being simple in technology and low in requirements for equipment, being capable of saving energy and reducing consumption, and the like.

Description

A kind of fabricating technology of new type water dispersible granule

Technical field

The invention belongs to pesticide field, be specifically related to the novel processing technology technology of a kind of water dispersible granules。

Background technology

Pesticide water dispersible granules is a kind of novel form that grows up the 1980s。Because its safety is good, environmentally safe, the advantage with Traditional Agricultural pharmaceutically dosage form, it is believed that be an important directions of formulations of pesticide development。Sketched water dispersible granules progress at home and abroad herein, to its auxiliary agent, compound method, prilling process development trend carried out preliminary discussion。WDG becomes one of the most promising product in a new generation's insecticidal formulation surely。Water dispersible granules is a kind of pesticides new formulation grown up America and Europe early 1980s, and also referred to as dry suspension, international community of pesticide industry association (GIFAR) is defined as: the granule used after disintegrate and dispersion in water。Water dispersible granules is mainly made up of pesticide active ingredient, dispersant, wetting agent, binding agent, disintegrating agent and filler, 200 μm of-5mm of particle diameter, enter after water can disintegrate rapidly, dispersion, form higher suspension dispersion。

The advantage of water-dispersible granules is in that: 1. without organic solvent, greatly reduces environmental pollution；There is no dust from flying during sprinkling, to operator's safety, decrease the pollution to environment；2. active constituent content is high, and the auxiliary agent of interpolation is few, and product is relatively denser, volume packaging little, easy, easy storage and transport, has very strong economic benefit and social benefit；3. physical and chemical stability is good, particularly unstable in water pesticide, after making water dispersible granules, more stable；4. entering water easy disintegrating, good dispersion, suspensibility is high, and drug effect is high。5. good fluidity, not viscous wall, pack disposable；6. safety is good, be compatible with the environment, added value high, and market potential is big, it is believed that be 2l century one of dosage form most with prospects。

Conventional aqueous shot agent processing technology processing charges is high, and environmental pollution is big, complex process equipment, and the capital expenditure developed and produce is big, and fabrication process condition is harsh, and process technology is very complicated, and processing cost is high。This invention makes the scattered product technical method of moisture innovate further and improve, and well solves the problems such as current water dispersible granules energy consumption is big, and more simple in technology controlling and process so that more easy to control in production, simple operation, yield is higher。

Summary of the invention

The invention aims to solve current conventional aqueous and dissipate processing technology processing charges height, the defects such as process technology is complicated, this method makes medicated powder uniformly be wrapped in sol particle by a certain amount of binding agent, form granule, then the scattered processing technology of water is dried to obtain, thus it is big to solve energy consumption consumption in the scattered processing technology of current moisture, the difficult problems such as the difficult control of operation, making water dispersible granules reach the requirement of cleanly production, this is also that water dispersible granules produces upper one and novel prepares technology。

The present invention is achieved through the following technical solutions:

A kind of water dispersible granules novel preparation process technology, this technical formula composition includes pesticide active ingredient, wetting agent, dispersant, disintegrating agent, binding agent, carrier。Wherein said pesticide active ingredient is high-melting-point pesticide, and mass fraction is 1-60%；The mass fraction of described wetting agent is 0.5%-5%；The mass fraction of dispersant is 2-10%；The mass fraction of disintegrating agent is 1-40%；The mass fraction of binding agent is 1-10%；All the other are filler。

Wherein said pesticide active ingredient is one or more compounded combination such as Difenoconazole, Affirm (Merck Co.), pymetrozine, Fluoxastrobin, Tebuconazole, hexaconazole。

Described wetting agent selects one or both the mixing in fatty alcohol-polyoxyethylene ether, Aerosol OT, sodium lauryl sulphate。

Described dispersant selects EO-PO block copolymer, methacrylic acid/methyl methacrylate and one or several the mixing in polyoxyethylated copolymer, polycarboxylate salt dispersant, naphthalenesulfonate formaldehyde condensation compound, lignosulfonates。

Described binding agent is the one in PVA, Polyethylene Glycol, wood sodium, dextrin or combination。

Described carrier is the ammonium sulfate of solubility, sodium sulfate, sodium chloride, one or more combination of white sugar。

New type water dispersible granule fabricating technology side provided by the invention is:

(1) accurately weigh pesticide active ingredient, wetting agent, dispersant, disintegrating agent etc. to join together in trough type mixing machine, mix and blend 30-40 minute, after coarse powder, carry out comminution by gas stream again obtain the medicated powder of required fineness；

(2) carrier granular is placed in mixer, adds a certain amount of adhesive solution or alcoholic solution so that carrier granular is fully by binding agent moistening so that it is have viscosity；

(3) medicated powder is mixed with the carrier granular after moistening, adds medicated powder while stirring so that medicated powder wraps remaining carrier particle surface uniformly, to be wrapped fully after, granule is gone to fluid bed drying plant is dried, namely obtain product after screening。

Water-dispersible grain agent producing process of the present invention and traditional preparation technology are very different, production operation is also more simplified, greatly save energy consumption, the feature of environmental protection is better, meet national policy and the growth requirement of industry cleanly production, produce for water dispersible granules and provide a kind of novel feasible Technology。

Detailed description of the invention

In order to be more fully understood that the essence of the present invention; below in conjunction with embodiment, present disclosure is described in further detail; content mentioned in embodiment is not limitation of the invention; the following stated is only used for explaining the present invention; for not necessarily departing from amendment, replacement or the improvement that present invention spirit is made with principle, belong to the scope of protection of present invention。

Embodiment 1:

Weigh Difenoconazole 10 parts, sodium lauryl sulphate 2 parts, polycarboxylate 5 parts, naphthalene sulfonate 4 points, white sugar 10 parts, add in mixer and stir, cross comminution by gas stream to being required fineness；60 parts of graininess ammonium sulfate are placed in mixer, add 5 parts of PVA aqueous solutions, make the abundant moistening of ammonium sulfate, gradation addition medicated powder stirring makes medicated powder uniformly wrap up and sticks to ammonium sulfate surface formation granule, and the granule wrapped goes to drying 10% difenoconazole water dispersible granule in drying plant。

Embodiment 2:

Weigh dimethomorph 50 parts, sodium lauryl sulphate 3 parts, polycarboxylate 4 parts, naphthalene sulfonate 4 points, add in mixer and stir, cross comminution by gas stream to being required fineness；30 parts of graininess ammonium sulfate are placed in mixer, add 9 parts of white sugar water solution, making the abundant moistening of ammonium sulfate, gradation addition medicated powder stirring makes medicated powder uniformly wrap up and sticks to ammonium sulfate surface formation granule, and the granule wrapped goes to drying 50% dimethomorph water dispersion granula in drying plant。

The above is only the preferred embodiment of the present invention; can be up to standard by the water dispersible granules product indices of the method gained; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also making some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention。

Claims

1. the Technology that prepared by a new type water dispersible granule, it is characterised in that: include pesticide active ingredient, wetting agent, dispersant, disintegrating agent, filler；Wherein, the former medicine 1-60% of pesticide active ingredient；Wetting agent 0.5%-5%；Dispersant 2-10%；Disintegrating agent 1-40%；Binding agent 1-10%；All the other are carrier, for mass fraction。

2. the fabricating technology of a kind of new type water dispersible granule according to claim 1, it is characterised in that: described pesticide active ingredient is Difenoconazole, Affirm (Merck Co.), pymetrozine, Fluoxastrobin, Tebuconazole, one or more compounded combination of hexaconazole。

3. the fabricating technology of a kind of new type water dispersible granule according to claim 1, it is characterised in that: described wetting agent selects one or both the mixing in fatty alcohol-polyoxyethylene ether, Aerosol OT, sodium lauryl sulphate。

4. the fabricating technology of a kind of new type water dispersible granule according to claim 1, it is characterised in that: described dispersant selects EO-PO block copolymer, methacrylic acid/methyl methacrylate and one or several the mixing in polyoxyethylated copolymer, polycarboxylate salt dispersant, naphthalenesulfonate formaldehyde condensation compound, lignosulfonates。

5. the fabricating technology of a kind of new type water dispersible granule according to claim 1, it is characterised in that: described binding agent is the mixing of one or more in PVA, Polyethylene Glycol, wood sodium, dextrin。

6. the fabricating technology of a kind of new type water dispersible granule according to claim 1, it is characterised in that: described carrier is the ammonium sulfate of solubility, sodium sulfate, sodium chloride, one or more mixing of white sugar。

7. the preparation method of the fabricating technology of a new type water dispersible granule is: in the ratio described in claim 1, after pesticide active ingredient, wetting agent, dispersant, disintegrating agent are sufficiently mixed coarse pulverization, cross comminution by gas stream and obtain the medicated powder that fineness is qualified, a certain amount of binding agent is used for moistening carrier granular, carrier is made to possess the viscosity of bonding medicated powder, medicated powder is added mix and blend in carrier so that gained granule, on carrier, is dried after uniformly by medicated powder uniform adhesion wait adhering to。