CN110432265A - A kind of pesticide water dispersible granules and preparation method thereof - Google Patents

A kind of pesticide water dispersible granules and preparation method thereof Download PDF

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Publication number
CN110432265A
CN110432265A CN201910654215.8A CN201910654215A CN110432265A CN 110432265 A CN110432265 A CN 110432265A CN 201910654215 A CN201910654215 A CN 201910654215A CN 110432265 A CN110432265 A CN 110432265A
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parts
pesticide
dispersible granules
water dispersible
agent
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CN201910654215.8A
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CN110432265B (en
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郑晓成
徐菊
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HEBEI SHUANGJI CHEMICAL CO Ltd
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HEBEI SHUANGJI CHEMICAL CO Ltd
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12Powders or granules
    • A01N25/14Powders or granules wettable
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/34Nitriles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46N-acyl derivatives
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/501,3-Diazoles; Hydrogenated 1,3-diazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A01N47/14Di-thio analogues thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products

Abstract

The invention belongs to technical field of pesticide preparations, a kind of pesticide water dispersible granules and preparation method thereof are proposed.A kind of pesticide water dispersible granules, it is grouped as by the group of following parts by weight: 15~70 parts of pesticide activity component, 5~10 parts of dispersing agent, 2~5 parts of wetting agent, 5.5~9 parts of disintegrating agent, 1~4 part of binder, 2~10 parts of filler, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5.First pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing in preparation method, be dissolved in water after wetting agent, binder be mixed to get suspension, will be mixed after spray dried with filler, extrusion granulation, drying.Through the above technical solutions, solving the problems, such as that the formula of prior art water dispersible granules is single, the scope of application is small.

Description

A kind of pesticide water dispersible granules and preparation method thereof
Technical field
The invention belongs to technical field of pesticide preparations, it is related to a kind of pesticide water dispersible granules and preparation method thereof.
Background technique
Water dispersible granules are a kind of environment-friendly pesticide novel forms of research and development the 1980s, be in wettable powder and Grow up on the basis of suspending agent.The dosage form reduces the pollution to environment in processing and use process, and conveniently Metering, packaging and transport, reduce peasant's use cost, are a main trend of current Agrochemicals.
Currently, water dispersible granules are mainly by the components structure such as bulk pharmaceutical chemicals, dispersing agent, wetting agent, disintegrating agent, binder, filler At the selection of auxiliary agent is to influence wetability, the key factor of disintegration and suspension of water dispersible granules, and then affect medical fluid In plant surface hold-up, residence time and in the penetration capacity of plant epidermis, pesticide bioactivity is influenced, in the prior art The formula of water dispersible granules is single, sensitive to raw materials variations, the same raw medicine of especially different manufacturers, and use is identical Formula production water dispersible granules, performance also have biggish difference, therefore, study a kind of pesticide water-dispersible grain that applicability is good Agent, it is necessary for the utilization rate for improving pesticide active ingredient.
Summary of the invention
The present invention proposes a kind of pesticide water dispersible granules and preparation method thereof, solves water dispersible granules in the prior art It is formulated problem single, that the scope of application is small.
The technical scheme of the present invention is realized as follows:
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
15~70 parts of pesticide activity component, 5~10 parts of dispersing agent, 2~5 parts of wetting agent, 5.5~9 parts of disintegrating agent, binder 1~4 part, 2~10 parts of filler.
As further technical solution, it is grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler.
As further technical solution, the dispersing agent is that poloxamer, chitosan and citric acid mass ratio are 4:1: 1.5 mixture.
As further technical solution, the pesticide activity component be cyazofamid, Mancozeb, metalaxyl, cymoxanil, One or both of carbendazim, Bravo.
As further technical solution, the wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio For the mixture of 2:1:1.
As further technical solution, the disintegrating agent is sodium tripolyphosphate, in sodium carboxymethyl starch, microcrystalline cellulose It is one or more.
As further technical solution, the binder is carboxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidine One of ketone, sucrose are a variety of.
As further technical solution, the filler be one of bentonite, kaolin, diatomite, white carbon black or It is a variety of.
A kind of preparation method of pesticide water dispersible granules, comprising the following steps:
S1. according to the formula of above-mentioned pesticide water dispersible granules, it is spare to weigh each component;
S2. pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing, obtains mixed powder;
S3. suspension is mixed to get with mixed powder after dissolving wetting agent, binder with water;
S4. the obtained spray dried of step S3 is removed into extra moisture, obtains particle;
S5. the obtained particle of step S4 is uniformly mixed with filler, extrusion granulation, after drying, obtains a kind of pesticide moisture Shot agent.
As further technical solution, the weight ratio of water and wetting agent is 45~55:1 in step S3.
It the working principle of the invention and has the beneficial effect that
1, it in the present invention, using pesticide activity component as major ingredient, adds the dispersing agent of specific components, wetting agent, disintegrating agent, glue Knot agent and filler, various components mutually cooperate with, so that the pesticide water dispersible granules suspensibility of preparation is up to 93.7%, wetting time Down to 52s, disintegration time is down to 42s, and in (54 ± 2) DEG C constant temperature oven, suspensibility, wetting time after storage 14 days, Disintegration time variation is small, has good suspension, disintegration, wetability and heat storage stability, this improves pesticide moisture Shot agent extends the residence time in the hold-up of plant surface, to improve the bioactivity of pesticide activity component, improves The utilization rate of pesticide activity component reduces dosage, reduces cost, is suitble to promote the use of.
2, in the present invention, first pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing in preparation method, In Be dissolved in water after wetting agent, binder be mixed to get suspension, will be mixed after spray dried with filler, squeeze and make Grain, drying and etc. so that in pesticide water dispersible granules each component disperse it is more uniform, improve each component collaboration make With, and then improve the dispersion stabilization of pesticide water dispersible granules.
3, in the present invention, each component cooperates with compatibility in formula, so that the water dispersible granules of preparation are directed to different types of agriculture The compounding of pharmaceutically active ingredient and two kinds of pesticide active ingredients all has good suspension, disintegration, wetability and suspends steady Qualitative, therefore, rationally, the scope of application is wider, and applicability is stronger for formula, is suitble to promote the use of.
4, in the present invention, wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are the mixed of 2.5:1:2 Close object, polyethylene glycol, polyethyleneimine, Sodium Polyacrylate three compounding, so that the pesticide water dispersible granules of preparation have very well Wetability, wetting time is short, polyethylene glycol, polyethyleneimine, Sodium Polyacrylate have good water solubility, three cooperation, Cooperateed with while improving wetability with the dispersing agent in formula, improve the suspensions of pesticide water dispersible granules, disintegration and Heat storage stability.
5, in the present invention, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, point Poloxamer, chitosan and citric acid cooperate in powder, significantly improve the dispersion performance and heat of pesticide water dispersible granules Store stability.Poloxamer is polyoxyethylene-poly-oxypropylene polyoxyethylene triblock copolymer, polyoxyethylene chain in strand With relative hydropathy, can making pesticide activity component, dispersion and stable suspersion, polyoxypropylene chains have well in aqueous solution There is lipophilicity relatively, there can be good compatibility between pesticide activity component, be formed with pesticide activity component stable Mutual structure, further enhances the suspension stability of pesticide water dispersible granules, and poloxamer and chitosan pass through hydrogen bond in water Assembling forms stable molecular structure, and the backbone in chitosan increases steric hindrance, enhances dispersing agent and pesticide is living Active force between property ingredient, improves the heat storage stability of pesticide water dispersible granules, acyclic acidic has been built in the addition of citric acid Border promotes the dissolution of chitosan in water, enhances the interaction between poloxamer and chitosan, and furthermore chitosan is also With good permeability, pesticide water dispersible granules can be improved in the penetration capacity of plant epidermis, to improve pesticide biology Activity reduces dosage, reduces cost, improve the cost performance of pesticide water dispersible granules, practical.
6, in the present invention, poloxamer aqueous solution of the mass fraction for 20% will be first prepared in the preparation method of dispersing agent, Chitosan is added after lemon acid dissolution is added, freeze-drying obtains dispersing agent after completely dissolution, and specific preparation method can Retain the effective component in dispersing agent to the greatest extent, so that the effect of dispersing agent in pesticide water dispersible granules is able to adequately It plays.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.
Embodiment 1
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
15 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 5.5 parts of disintegrating agent, 1 part of binder, 2 parts of filler,
Wherein, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, pesticide activity Ingredient is cyazofamid, the mixture that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1, disintegration Agent is sodium tripolyphosphate, and binder is carboxymethyl cellulose, and filler is bentonite,
Preparation method includes the following steps:
S1. according to above-mentioned formula, it is spare to weigh each component;
S2. pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing, obtains mixed powder;
S3. suspension is mixed to get after dissolving wetting agent, binder with water with mixed powder, wherein the weight of water and wetting agent Amount is than being 50:1;
S4. the obtained spray dried of step S3 is removed into extra moisture, obtains particle;
S5. the obtained particle of step S4 is uniformly mixed with filler, extrusion granulation, after drying, obtains a kind of pesticide moisture Shot agent.
Embodiment 2
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
70 parts of pesticide activity component, 10 parts of dispersing agent, 5 parts of wetting agent, 9 parts of disintegrating agent, 4 parts of binder, 10 parts of filler,
Wherein, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, pesticide activity Ingredient is cyazofamid, the mixture that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1, disintegration Agent is sodium tripolyphosphate, and binder is carboxymethyl cellulose, and filler is bentonite,
The weight ratio of water and wetting agent is 55:1 in step S3, remaining preparation step is the same as embodiment 1.
Embodiment 3
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler,
Wherein, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, pesticide activity Ingredient is cyazofamid, the mixture that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1, disintegration Agent is sodium tripolyphosphate, and binder is carboxymethyl cellulose, and filler is bentonite,
The weight ratio of water and wetting agent is 45:1 in step S3, remaining preparation step is the same as embodiment 1.
Embodiment 4
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 6 parts of disintegrating agent, 2.5 parts of binder, 2 parts of filler, In, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is white urea The mixture that cyanogen and Mancozeb mass ratio are 8:1, wetting agent are polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio For the mixture of 2:1:1, disintegrating agent is sodium carboxymethyl starch, and binder is polyvinyl alcohol, and filler is kaolin,
Preparation method is the same as embodiment 1.
Embodiment 5
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
38 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler, In, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is first frost The mixture that spirit and Mancozeb mass ratio are 24:5, wetting agent are polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio For the mixture of 2:1:1, the mixture that disintegrating agent is sodium tripolyphosphate and sodium carboxymethyl starch mass ratio is 1:1, binder is Sucrose, filler are white carbon black,
Preparation method is the same as embodiment 1.
Embodiment 6
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
20 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 8.5 parts of filler, Wherein, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is cyanogen The mixture that white azoles and cymoxanil mass ratio are 1:4, wetting agent are polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio For the mixture of 2:1:1, the mixture that disintegrating agent is sodium tripolyphosphate and microcrystalline cellulose mass ratio is 1:1, binder is carboxylic The mixture that methylcellulose and polyvinyl alcohol mass ratio are 1:1, filler is bentonite,
Preparation method is the same as embodiment 1.
Embodiment 7
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler, In, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is more bacterium Spirit, the mixture that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1, disintegrating agent is carboxymethyl Sodium starch, binder are polyvinyl alcohol, and filler is kaolin,
Preparation method is the same as embodiment 1.
In Examples 1 to 7 dispersing agent the preparation method comprises the following steps: by poloxamer be dissolved in a certain amount of water be made concentration be Citric acid is added into poloxamer aqueous solution, chitosan is added after dissolution, after mixing for 20% poloxamer aqueous solution Freeze-drying, obtains dispersing agent.
Comparative example 1
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 6 parts of disintegrating agent, 2.5 parts of binder, 2 parts of filler, In, dispersing agent is poloxamer, the mixture that pesticide activity component is cymoxanil and Mancozeb mass ratio is 8:1, wetting agent The mixture for being 2:1:1 for polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio, disintegrating agent are sodium carboxymethyl starch, are glued Knot agent is polyvinyl alcohol, and filler is kaolin,
Preparation method is the same as embodiment 1.
Comparative example 2
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 6 parts of disintegrating agent, 2.5 parts of binder, 2 parts of filler, In, dispersing agent is chitosan, the mixture that pesticide activity component is cymoxanil and Mancozeb mass ratio is 8:1, and wetting agent is Polyethylene glycol, polyethyleneimine, the mixture that Sodium Polyacrylate mass ratio is 2:1:1, disintegrating agent is sodium carboxymethyl starch, bonding Agent is polyvinyl alcohol, and filler is kaolin,
Preparation method is the same as embodiment 1.
Comparative example 3
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 6 parts of disintegrating agent, 2.5 parts of binder, 2 parts of filler, In, dispersing agent is poloxamer, chitosan mass than the mixture for 4:1, and pesticide activity component is cymoxanil and Mancozeb Mass ratio is the mixture of 8:1, the mixing that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1 Object, disintegrating agent are sodium carboxymethyl starch, and binder is polyvinyl alcohol, and filler is kaolin;Dispersing agent the preparation method comprises the following steps: will pool Luo Shamu is dissolved in the poloxamer aqueous solution for being made that concentration is 20% in a certain amount of water, is added into poloxamer aqueous solution Chitosan is freeze-dried after mixing, obtains dispersing agent;
Preparation method is the same as embodiment 1.
Comparative example 4
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler, In, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is white urea The mixture that cyanogen and Mancozeb mass ratio are 8:1, wetting agent are polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio For the mixture of 2:1:1, disintegrating agent is sodium carboxymethyl starch, and binder is polyvinyl alcohol, and filler is kaolin, the system of dispersing agent Preparation Method is to be dissolved in poloxamer in a certain amount of water that the poloxamer aqueous solution that concentration is 20% is made, to poloxamer Citric acid is added in aqueous solution, chitosan is added after dissolution, is dried in vacuo after mixing at 60 DEG C, obtains dispersing agent,
Preparation method is the same as embodiment 1.
The pesticide water dispersible granules prepared to Examples 1 to 7 and comparative example 1~3 perform the following performance tests:
1, suspensibility: according to method test sample specified in GB/T14825-2006 " agricultural-chemical suspension rate measuring method " Suspensibility;
2, wetability: measuring graduates test method(s) is used, is quickly poured into the graduated cylinder of Xiang Shengyou 500mL342mg/L hardness water 1.0g sample, does not stir, and 99% sample of record sinks to the time at bottom.
3, disintegration: measuring graduates test method(s) is used, 90mL distilled water is added in 100mL tool plug graduated cylinder, adds at 25 DEG C Enter 0.5g particulate samples, clamp the middle part of graduated cylinder, clog nozzle, rotated with the speed of 8r/min around center, until sample is in water In be disintegrated completely, record disintegration time.
4, heat storage stability:, will about according to the regulation in GB/T19136-2003 " pesticide heat storage stability " measuring method 5g sample is sealed in 50ml ampoule bottle, is placed in (54 ± 2) DEG C constant temperature oven, and storage is taken out after 14 days, the side in 1,2,3 Method measures the suspensibility of sample, wetability, disintegration, and test result see the table below:
The performance test results of the pesticide water dispersible granules of 1 Examples 1 to 7 grade comparative example 1~3 of table preparation
From table 1 it follows that compared with pesticide water dispersible granules prepared by comparative example 1~4, the embodiment of the present invention 1~7 The pesticide water dispersible granules suspensibility of preparation is high, wetting time is short, disintegration time is short, and suspensibility is up to 93.7%, wetting time Down to 52s, disintegration time is down to 42s, and in (54 ± 2) DEG C constant temperature oven, suspensibility, wetting time after storage 14 days, Disintegration time variation it is small, illustrate pesticide water dispersible granules prepared by the present invention have good suspension, disintegration, wetability and Heat storage stability.Mixing for different types of pesticide activity component and two kinds of pesticide active ingredients, the pesticide water of preparation Dispersible granule all has good suspension, disintegration, wetability and heat storage stability, illustrates water-dispersible grain prepared by the present invention Agent is stronger to the applicability of different types of pesticide activity component, and therefore, the scope of application is wider, is suitble to promote the use of.
Compared with Example 4, there was only poloxamer in the dispersing agent of the pesticide water dispersible granules of comparative example 1, comparative example 2 There was only chitosan in the dispersing agent of pesticide water dispersible granules, only pool Lip river is husky in the dispersing agent of 3 pesticide water dispersible granules of comparative example Nurse and chitosan, using in 60 DEG C of vacuum after mixing completely in the dispersant preparation method of the pesticide water dispersible granules of comparative example 4 Dry mode, as a result compared with Example 4, the pesticide water dispersible granules disintegration time of comparative example 1 is longer, and heat storage stability is more Difference, suspensibility relative reduction, wetting time are relatively longer;Suspensibility is worse in the pesticide water dispersible granules of comparative example 2, when wetting Between it is longer, disintegration time is relatively longer, and heat storage stability is worse;Suspensibility is relatively more in the pesticide water dispersible granules of comparative example 3 Difference, wetting time, disintegration time are relatively longer, and heat storage stability is relatively worse;The pesticide water dispersible granules heat storage of comparative example 4 is steady Qualitative worse, suspensibility is relatively worse, and wetting time, disintegration time are relatively longer, this is to illustrate poloxamer in dispersing agent, shell Glycan and citric acid cooperate, and significantly improve the dispersion performance and heat storage stability of pesticide water dispersible granules, dispersing agent The effective component in dispersing agent can be retained in preparation method to the greatest extent by the way of freeze-drying, so that dispersing agent exists Effect in pesticide water dispersible granules is fully played.
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all in spirit of the invention and Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of pesticide water dispersible granules, which is characterized in that be grouped as by the group of following parts by weight:
15~70 parts of pesticide activity component, 5~10 parts of dispersing agent, 2~5 parts of wetting agent, 5.5~9 parts of disintegrating agent, binder 1~4 Part, 2~10 parts of filler.
2. a kind of pesticide water dispersible granules according to claim 1, which is characterized in that be grouped by the group of following parts by weight At:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler.
3. a kind of pesticide water dispersible granules according to claim 1 or 2, which is characterized in that the dispersing agent is that pool Lip river is husky Nurse, chitosan and citric acid mass ratio are the mixture of 4:1:1.5.
4. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the pesticide activity component is cyanogen frost One or both of azoles, Mancozeb, metalaxyl, cymoxanil, carbendazim, Bravo.
5. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the wetting agent be polyethylene glycol, Polyethyleneimine, the mixture that Sodium Polyacrylate mass ratio is 2.5:1:2.
6. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the disintegrating agent is tripolyphosphate One of sodium, sodium carboxymethyl starch, microcrystalline cellulose are a variety of.
7. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the binder is carboxymethyl cellulose One of element, polyvinyl alcohol, polyvinylpyrrolidone, sucrose are a variety of.
8. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the filler is bentonite, kaolinite One of soil, diatomite, white carbon black are a variety of.
9. a kind of preparation method of pesticide water dispersible granules, which comprises the following steps:
S1. according to the formula of pesticide water dispersible granules described in claim 3~8 any one, it is spare to weigh each component;
S2. pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing, obtains mixed powder;
S3. suspension is mixed to get with mixed powder after dissolving wetting agent, binder with water;
S4. the obtained spray dried of step S3 is removed into extra moisture, obtains particle;
S5. the obtained particle of step S4 is uniformly mixed with filler, extrusion granulation, after drying, obtains a kind of pesticide water-dispersible grain Agent.
10. a kind of preparation method of pesticide water dispersible granules according to claim 9, which is characterized in that water in step S3 Weight ratio with wetting agent is 45~55:1.
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