CN110432265A - A kind of pesticide water dispersible granules and preparation method thereof - Google Patents
A kind of pesticide water dispersible granules and preparation method thereof Download PDFInfo
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- CN110432265A CN110432265A CN201910654215.8A CN201910654215A CN110432265A CN 110432265 A CN110432265 A CN 110432265A CN 201910654215 A CN201910654215 A CN 201910654215A CN 110432265 A CN110432265 A CN 110432265A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
- A01N47/14—Di-thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
Abstract
The invention belongs to technical field of pesticide preparations, a kind of pesticide water dispersible granules and preparation method thereof are proposed.A kind of pesticide water dispersible granules, it is grouped as by the group of following parts by weight: 15~70 parts of pesticide activity component, 5~10 parts of dispersing agent, 2~5 parts of wetting agent, 5.5~9 parts of disintegrating agent, 1~4 part of binder, 2~10 parts of filler, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5.First pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing in preparation method, be dissolved in water after wetting agent, binder be mixed to get suspension, will be mixed after spray dried with filler, extrusion granulation, drying.Through the above technical solutions, solving the problems, such as that the formula of prior art water dispersible granules is single, the scope of application is small.
Description
Technical field
The invention belongs to technical field of pesticide preparations, it is related to a kind of pesticide water dispersible granules and preparation method thereof.
Background technique
Water dispersible granules are a kind of environment-friendly pesticide novel forms of research and development the 1980s, be in wettable powder and
Grow up on the basis of suspending agent.The dosage form reduces the pollution to environment in processing and use process, and conveniently
Metering, packaging and transport, reduce peasant's use cost, are a main trend of current Agrochemicals.
Currently, water dispersible granules are mainly by the components structure such as bulk pharmaceutical chemicals, dispersing agent, wetting agent, disintegrating agent, binder, filler
At the selection of auxiliary agent is to influence wetability, the key factor of disintegration and suspension of water dispersible granules, and then affect medical fluid
In plant surface hold-up, residence time and in the penetration capacity of plant epidermis, pesticide bioactivity is influenced, in the prior art
The formula of water dispersible granules is single, sensitive to raw materials variations, the same raw medicine of especially different manufacturers, and use is identical
Formula production water dispersible granules, performance also have biggish difference, therefore, study a kind of pesticide water-dispersible grain that applicability is good
Agent, it is necessary for the utilization rate for improving pesticide active ingredient.
Summary of the invention
The present invention proposes a kind of pesticide water dispersible granules and preparation method thereof, solves water dispersible granules in the prior art
It is formulated problem single, that the scope of application is small.
The technical scheme of the present invention is realized as follows:
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
15~70 parts of pesticide activity component, 5~10 parts of dispersing agent, 2~5 parts of wetting agent, 5.5~9 parts of disintegrating agent, binder
1~4 part, 2~10 parts of filler.
As further technical solution, it is grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler.
As further technical solution, the dispersing agent is that poloxamer, chitosan and citric acid mass ratio are 4:1:
1.5 mixture.
As further technical solution, the pesticide activity component be cyazofamid, Mancozeb, metalaxyl, cymoxanil,
One or both of carbendazim, Bravo.
As further technical solution, the wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio
For the mixture of 2:1:1.
As further technical solution, the disintegrating agent is sodium tripolyphosphate, in sodium carboxymethyl starch, microcrystalline cellulose
It is one or more.
As further technical solution, the binder is carboxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidine
One of ketone, sucrose are a variety of.
As further technical solution, the filler be one of bentonite, kaolin, diatomite, white carbon black or
It is a variety of.
A kind of preparation method of pesticide water dispersible granules, comprising the following steps:
S1. according to the formula of above-mentioned pesticide water dispersible granules, it is spare to weigh each component；
S2. pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing, obtains mixed powder；
S3. suspension is mixed to get with mixed powder after dissolving wetting agent, binder with water；
S4. the obtained spray dried of step S3 is removed into extra moisture, obtains particle；
S5. the obtained particle of step S4 is uniformly mixed with filler, extrusion granulation, after drying, obtains a kind of pesticide moisture
Shot agent.
As further technical solution, the weight ratio of water and wetting agent is 45~55:1 in step S3.
It the working principle of the invention and has the beneficial effect that
1, it in the present invention, using pesticide activity component as major ingredient, adds the dispersing agent of specific components, wetting agent, disintegrating agent, glue
Knot agent and filler, various components mutually cooperate with, so that the pesticide water dispersible granules suspensibility of preparation is up to 93.7%, wetting time
Down to 52s, disintegration time is down to 42s, and in (54 ± 2) DEG C constant temperature oven, suspensibility, wetting time after storage 14 days,
Disintegration time variation is small, has good suspension, disintegration, wetability and heat storage stability, this improves pesticide moisture
Shot agent extends the residence time in the hold-up of plant surface, to improve the bioactivity of pesticide activity component, improves
The utilization rate of pesticide activity component reduces dosage, reduces cost, is suitble to promote the use of.
2, in the present invention, first pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing in preparation method, In
Be dissolved in water after wetting agent, binder be mixed to get suspension, will be mixed after spray dried with filler, squeeze and make
Grain, drying and etc. so that in pesticide water dispersible granules each component disperse it is more uniform, improve each component collaboration make
With, and then improve the dispersion stabilization of pesticide water dispersible granules.
3, in the present invention, each component cooperates with compatibility in formula, so that the water dispersible granules of preparation are directed to different types of agriculture
The compounding of pharmaceutically active ingredient and two kinds of pesticide active ingredients all has good suspension, disintegration, wetability and suspends steady
Qualitative, therefore, rationally, the scope of application is wider, and applicability is stronger for formula, is suitble to promote the use of.
4, in the present invention, wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are the mixed of 2.5:1:2
Close object, polyethylene glycol, polyethyleneimine, Sodium Polyacrylate three compounding, so that the pesticide water dispersible granules of preparation have very well
Wetability, wetting time is short, polyethylene glycol, polyethyleneimine, Sodium Polyacrylate have good water solubility, three cooperation,
Cooperateed with while improving wetability with the dispersing agent in formula, improve the suspensions of pesticide water dispersible granules, disintegration and
Heat storage stability.
5, in the present invention, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, point
Poloxamer, chitosan and citric acid cooperate in powder, significantly improve the dispersion performance and heat of pesticide water dispersible granules
Store stability.Poloxamer is polyoxyethylene-poly-oxypropylene polyoxyethylene triblock copolymer, polyoxyethylene chain in strand
With relative hydropathy, can making pesticide activity component, dispersion and stable suspersion, polyoxypropylene chains have well in aqueous solution
There is lipophilicity relatively, there can be good compatibility between pesticide activity component, be formed with pesticide activity component stable
Mutual structure, further enhances the suspension stability of pesticide water dispersible granules, and poloxamer and chitosan pass through hydrogen bond in water
Assembling forms stable molecular structure, and the backbone in chitosan increases steric hindrance, enhances dispersing agent and pesticide is living
Active force between property ingredient, improves the heat storage stability of pesticide water dispersible granules, acyclic acidic has been built in the addition of citric acid
Border promotes the dissolution of chitosan in water, enhances the interaction between poloxamer and chitosan, and furthermore chitosan is also
With good permeability, pesticide water dispersible granules can be improved in the penetration capacity of plant epidermis, to improve pesticide biology
Activity reduces dosage, reduces cost, improve the cost performance of pesticide water dispersible granules, practical.
6, in the present invention, poloxamer aqueous solution of the mass fraction for 20% will be first prepared in the preparation method of dispersing agent,
Chitosan is added after lemon acid dissolution is added, freeze-drying obtains dispersing agent after completely dissolution, and specific preparation method can
Retain the effective component in dispersing agent to the greatest extent, so that the effect of dispersing agent in pesticide water dispersible granules is able to adequately
It plays.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
15 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 5.5 parts of disintegrating agent, 1 part of binder, 2 parts of filler,
Wherein, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, pesticide activity
Ingredient is cyazofamid, the mixture that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1, disintegration
Agent is sodium tripolyphosphate, and binder is carboxymethyl cellulose, and filler is bentonite,
Preparation method includes the following steps:
S1. according to above-mentioned formula, it is spare to weigh each component；
S2. pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing, obtains mixed powder；
S3. suspension is mixed to get after dissolving wetting agent, binder with water with mixed powder, wherein the weight of water and wetting agent
Amount is than being 50:1；
S4. the obtained spray dried of step S3 is removed into extra moisture, obtains particle；
S5. the obtained particle of step S4 is uniformly mixed with filler, extrusion granulation, after drying, obtains a kind of pesticide moisture
Shot agent.
Embodiment 2
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
70 parts of pesticide activity component, 10 parts of dispersing agent, 5 parts of wetting agent, 9 parts of disintegrating agent, 4 parts of binder, 10 parts of filler,
Wherein, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, pesticide activity
Ingredient is cyazofamid, the mixture that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1, disintegration
Agent is sodium tripolyphosphate, and binder is carboxymethyl cellulose, and filler is bentonite,
The weight ratio of water and wetting agent is 55:1 in step S3, remaining preparation step is the same as embodiment 1.
Embodiment 3
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler,
Wherein, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, pesticide activity
Ingredient is cyazofamid, the mixture that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1, disintegration
Agent is sodium tripolyphosphate, and binder is carboxymethyl cellulose, and filler is bentonite,
The weight ratio of water and wetting agent is 45:1 in step S3, remaining preparation step is the same as embodiment 1.
Embodiment 4
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 6 parts of disintegrating agent, 2.5 parts of binder, 2 parts of filler,
In, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is white urea
The mixture that cyanogen and Mancozeb mass ratio are 8:1, wetting agent are polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio
For the mixture of 2:1:1, disintegrating agent is sodium carboxymethyl starch, and binder is polyvinyl alcohol, and filler is kaolin,
Preparation method is the same as embodiment 1.
Embodiment 5
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
38 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler,
In, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is first frost
The mixture that spirit and Mancozeb mass ratio are 24:5, wetting agent are polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio
For the mixture of 2:1:1, the mixture that disintegrating agent is sodium tripolyphosphate and sodium carboxymethyl starch mass ratio is 1:1, binder is
Sucrose, filler are white carbon black,
Preparation method is the same as embodiment 1.
Embodiment 6
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
20 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 8.5 parts of filler,
Wherein, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is cyanogen
The mixture that white azoles and cymoxanil mass ratio are 1:4, wetting agent are polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio
For the mixture of 2:1:1, the mixture that disintegrating agent is sodium tripolyphosphate and microcrystalline cellulose mass ratio is 1:1, binder is carboxylic
The mixture that methylcellulose and polyvinyl alcohol mass ratio are 1:1, filler is bentonite,
Preparation method is the same as embodiment 1.
Embodiment 7
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler,
In, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is more bacterium
Spirit, the mixture that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1, disintegrating agent is carboxymethyl
Sodium starch, binder are polyvinyl alcohol, and filler is kaolin,
Preparation method is the same as embodiment 1.
In Examples 1 to 7 dispersing agent the preparation method comprises the following steps: by poloxamer be dissolved in a certain amount of water be made concentration be
Citric acid is added into poloxamer aqueous solution, chitosan is added after dissolution, after mixing for 20% poloxamer aqueous solution
Freeze-drying, obtains dispersing agent.
Comparative example 1
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 6 parts of disintegrating agent, 2.5 parts of binder, 2 parts of filler,
In, dispersing agent is poloxamer, the mixture that pesticide activity component is cymoxanil and Mancozeb mass ratio is 8:1, wetting agent
The mixture for being 2:1:1 for polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio, disintegrating agent are sodium carboxymethyl starch, are glued
Knot agent is polyvinyl alcohol, and filler is kaolin,
Preparation method is the same as embodiment 1.
Comparative example 2
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 6 parts of disintegrating agent, 2.5 parts of binder, 2 parts of filler,
In, dispersing agent is chitosan, the mixture that pesticide activity component is cymoxanil and Mancozeb mass ratio is 8:1, and wetting agent is
Polyethylene glycol, polyethyleneimine, the mixture that Sodium Polyacrylate mass ratio is 2:1:1, disintegrating agent is sodium carboxymethyl starch, bonding
Agent is polyvinyl alcohol, and filler is kaolin,
Preparation method is the same as embodiment 1.
Comparative example 3
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 5 parts of dispersing agent, 2 parts of wetting agent, 6 parts of disintegrating agent, 2.5 parts of binder, 2 parts of filler,
In, dispersing agent is poloxamer, chitosan mass than the mixture for 4:1, and pesticide activity component is cymoxanil and Mancozeb
Mass ratio is the mixture of 8:1, the mixing that wetting agent is polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio are 2:1:1
Object, disintegrating agent are sodium carboxymethyl starch, and binder is polyvinyl alcohol, and filler is kaolin；Dispersing agent the preparation method comprises the following steps: will pool
Luo Shamu is dissolved in the poloxamer aqueous solution for being made that concentration is 20% in a certain amount of water, is added into poloxamer aqueous solution
Chitosan is freeze-dried after mixing, obtains dispersing agent；
Preparation method is the same as embodiment 1.
Comparative example 4
A kind of pesticide water dispersible granules are grouped as by the group of following parts by weight:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler,
In, dispersing agent is the mixture that poloxamer, chitosan and citric acid mass ratio are 4:1:1.5, and pesticide activity component is white urea
The mixture that cyanogen and Mancozeb mass ratio are 8:1, wetting agent are polyethylene glycol, polyethyleneimine, Sodium Polyacrylate mass ratio
For the mixture of 2:1:1, disintegrating agent is sodium carboxymethyl starch, and binder is polyvinyl alcohol, and filler is kaolin, the system of dispersing agent
Preparation Method is to be dissolved in poloxamer in a certain amount of water that the poloxamer aqueous solution that concentration is 20% is made, to poloxamer
Citric acid is added in aqueous solution, chitosan is added after dissolution, is dried in vacuo after mixing at 60 DEG C, obtains dispersing agent,
Preparation method is the same as embodiment 1.
The pesticide water dispersible granules prepared to Examples 1 to 7 and comparative example 1~3 perform the following performance tests:
1, suspensibility: according to method test sample specified in GB/T14825-2006 " agricultural-chemical suspension rate measuring method "
Suspensibility；
2, wetability: measuring graduates test method(s) is used, is quickly poured into the graduated cylinder of Xiang Shengyou 500mL342mg/L hardness water
1.0g sample, does not stir, and 99% sample of record sinks to the time at bottom.
3, disintegration: measuring graduates test method(s) is used, 90mL distilled water is added in 100mL tool plug graduated cylinder, adds at 25 DEG C
Enter 0.5g particulate samples, clamp the middle part of graduated cylinder, clog nozzle, rotated with the speed of 8r/min around center, until sample is in water
In be disintegrated completely, record disintegration time.
4, heat storage stability:, will about according to the regulation in GB/T19136-2003 " pesticide heat storage stability " measuring method
5g sample is sealed in 50ml ampoule bottle, is placed in (54 ± 2) DEG C constant temperature oven, and storage is taken out after 14 days, the side in 1,2,3
Method measures the suspensibility of sample, wetability, disintegration, and test result see the table below:
The performance test results of the pesticide water dispersible granules of 1 Examples 1 to 7 grade comparative example 1~3 of table preparation
From table 1 it follows that compared with pesticide water dispersible granules prepared by comparative example 1~4, the embodiment of the present invention 1~7
The pesticide water dispersible granules suspensibility of preparation is high, wetting time is short, disintegration time is short, and suspensibility is up to 93.7%, wetting time
Down to 52s, disintegration time is down to 42s, and in (54 ± 2) DEG C constant temperature oven, suspensibility, wetting time after storage 14 days,
Disintegration time variation it is small, illustrate pesticide water dispersible granules prepared by the present invention have good suspension, disintegration, wetability and
Heat storage stability.Mixing for different types of pesticide activity component and two kinds of pesticide active ingredients, the pesticide water of preparation
Dispersible granule all has good suspension, disintegration, wetability and heat storage stability, illustrates water-dispersible grain prepared by the present invention
Agent is stronger to the applicability of different types of pesticide activity component, and therefore, the scope of application is wider, is suitble to promote the use of.
Compared with Example 4, there was only poloxamer in the dispersing agent of the pesticide water dispersible granules of comparative example 1, comparative example 2
There was only chitosan in the dispersing agent of pesticide water dispersible granules, only pool Lip river is husky in the dispersing agent of 3 pesticide water dispersible granules of comparative example
Nurse and chitosan, using in 60 DEG C of vacuum after mixing completely in the dispersant preparation method of the pesticide water dispersible granules of comparative example 4
Dry mode, as a result compared with Example 4, the pesticide water dispersible granules disintegration time of comparative example 1 is longer, and heat storage stability is more
Difference, suspensibility relative reduction, wetting time are relatively longer；Suspensibility is worse in the pesticide water dispersible granules of comparative example 2, when wetting
Between it is longer, disintegration time is relatively longer, and heat storage stability is worse；Suspensibility is relatively more in the pesticide water dispersible granules of comparative example 3
Difference, wetting time, disintegration time are relatively longer, and heat storage stability is relatively worse；The pesticide water dispersible granules heat storage of comparative example 4 is steady
Qualitative worse, suspensibility is relatively worse, and wetting time, disintegration time are relatively longer, this is to illustrate poloxamer in dispersing agent, shell
Glycan and citric acid cooperate, and significantly improve the dispersion performance and heat storage stability of pesticide water dispersible granules, dispersing agent
The effective component in dispersing agent can be retained in preparation method to the greatest extent by the way of freeze-drying, so that dispersing agent exists
Effect in pesticide water dispersible granules is fully played.
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of pesticide water dispersible granules, which is characterized in that be grouped as by the group of following parts by weight:
15~70 parts of pesticide activity component, 5~10 parts of dispersing agent, 2~5 parts of wetting agent, 5.5~9 parts of disintegrating agent, binder 1~4
Part, 2~10 parts of filler.
2. a kind of pesticide water dispersible granules according to claim 1, which is characterized in that be grouped by the group of following parts by weight
At:
45 parts of pesticide activity component, 8 parts of dispersing agent, 4 parts of wetting agent, 7 parts of disintegrating agent, 2.5 parts of binder, 6 parts of filler.
3. a kind of pesticide water dispersible granules according to claim 1 or 2, which is characterized in that the dispersing agent is that pool Lip river is husky
Nurse, chitosan and citric acid mass ratio are the mixture of 4:1:1.5.
4. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the pesticide activity component is cyanogen frost
One or both of azoles, Mancozeb, metalaxyl, cymoxanil, carbendazim, Bravo.
5. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the wetting agent be polyethylene glycol,
Polyethyleneimine, the mixture that Sodium Polyacrylate mass ratio is 2.5:1:2.
6. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the disintegrating agent is tripolyphosphate
One of sodium, sodium carboxymethyl starch, microcrystalline cellulose are a variety of.
7. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the binder is carboxymethyl cellulose
One of element, polyvinyl alcohol, polyvinylpyrrolidone, sucrose are a variety of.
8. a kind of pesticide water dispersible granules according to claim 3, which is characterized in that the filler is bentonite, kaolinite
One of soil, diatomite, white carbon black are a variety of.
9. a kind of preparation method of pesticide water dispersible granules, which comprises the following steps:
S1. according to the formula of pesticide water dispersible granules described in claim 3~8 any one, it is spare to weigh each component；
S2. pesticide active ingredient, dispersing agent, disintegrating agent are smashed after mixing, obtains mixed powder；
S3. suspension is mixed to get with mixed powder after dissolving wetting agent, binder with water；
S4. the obtained spray dried of step S3 is removed into extra moisture, obtains particle；
S5. the obtained particle of step S4 is uniformly mixed with filler, extrusion granulation, after drying, obtains a kind of pesticide water-dispersible grain
Agent.
10. a kind of preparation method of pesticide water dispersible granules according to claim 9, which is characterized in that water in step S3
Weight ratio with wetting agent is 45~55:1.
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Denomination of invention: A pesticide water dispersible granule and its preparation method Effective date of registration: 20230726 Granted publication date: 20210713 Pledgee: Cangzhou Bank Co.,Ltd. Xinji sub branch Pledgor: HEBEI SHUANGJI CHEMICAL Co.,Ltd. Registration number: Y2023980049871 |
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