CN105663748A - Traditional Chinese medicinal composition for treating type-2 diabetes combined hypertension - Google Patents

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicinal composition for treating type-2 diabetes combined hypertension. The traditional Chinese medicinal composition comprises, by weight, 4-8 parts of Cunninghamia Lanceolata, 4-8 parts of Radix Pecteitidis Susannae, 4-8 parts of Herba et Fructus Cynanchi Thesioidis, 4-8 parts of Dendrobium Densiflorum, 4-8 parts of rattlesnake plantain, 4-8 parts of Habenaria Delavayi Finet and 4-8 parts of liquorice. The traditional Chinese medicinal composition has the advantages that the effect of tonifying qi, nourishing yang and helping produce saliva and slake thirst is achieved by composition of various herbs, blood glucose and blood pressure of patients suffering from the type-2 diabetes combined hypertension can be reduced through application of the composition, and the curative effect on syndromes of Chinese medicine is remarkable.

Description

A kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension.

Background technology

Along with the prevalence of the quickening of Chinese society rapid development of economy, urbanization and aged tendency of population, diabetes and hypertension steeply rises, it has also become threaten the important sick of health of people to plant. China's population base is huge, and the number of diabetics accounts for the 1/3 of world's diabetics, and the prevalence of maturity-onset diabetes is up to 9.7%. Wherein diabetes mellitus type is most common type, and hyperpietic has also reached more than one hundred million people. Research finds, type 2 diabetes mellitus often merges with hypertension with existence and same patient, although the mechanism of its co-morbid not yet completely clearly, but shows therebetween comparatively intimate relation, bigger with the patient numbers of hypertension with suffering from patients with type Ⅰ DM.

Life and the quality of life of patient are produced to threaten greatly by diabetes, hypertension, bring white elephant also to the economy of society and the household economy of patient individual simultaneously, are also the key components of patient medical expense. Hypertension is by the impact on patient's big and small vessel, both the danger of the microvascular complication such as diabetic retinopathy, renal arteriosclerosis had been added, add again the danger of the macrovascular complications such as cerebrovascular disease, coronary heart disease, heart failure, improve the lethal disability rate of diabetes.

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that a kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension.

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension, is made up of the Chinese medicine of following weight portion:

China fir tower 4-8 part, Radix Pecteilis susannae 4-8 part, Herba Cynanchi Thesioidis 4-8 part, Dendrobium densiflorum lindl. 4-8 part, Herba goodyearae repentis 4-8 part, Radix Habenariae Delavayi 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine composition of above-mentioned treatment type 2 diabetes mellitus complicated hypertension, it is made up of the Chinese medicine of following weight portion:

China fir tower 5-7 part, Radix Pecteilis susannae 5-7 part, Herba Cynanchi Thesioidis 5-7 part, Dendrobium densiflorum lindl. 5-7 part, Herba goodyearae repentis 5-7 part, Radix Habenariae Delavayi 5-7 part, Radix Glycyrrhizae 5-7 part.

It is furthermore preferred that the Chinese medicine composition of above-mentioned treatment type 2 diabetes mellitus complicated hypertension, it is made up of the Chinese medicine of following weight portion:

6 parts of China fir tower, Radix Pecteilis susannae 6 parts, Herba Cynanchi Thesioidis 6 parts, Dendrobium densiflorum lindl. 6 parts, Herba goodyearae repentis 6 parts, Radix Habenariae Delavayi 6 parts, 6 parts of Radix Glycyrrhizae.

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or modest patient, it is possible to the proportioning of the corresponding amount adjusting composition, increases or reduces less than 100%, and drug effect is basically unchanged.

The weight portion of said medicine, if in units of g, it is common that the consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for treating type 2 diabetes mellitus complicated hypertension.

The taboo item of Chinese medicine of the present invention: treatment is taken medicine, and fasting was greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food period.

In the Chinese medicine composition of the present invention,

Shan Ta calls China fir fruit, Cunninghamia lanceolata (Lamb.) Hook. fruit, for the cone of taxodiaceae plant Lignum seu Ramulus Cunninghamiae Lanceolatae Cunninghamialanceolata (Lamb.) Hook. [PinuslanceolataLamb.]. Acrid in the mouth; Slightly warm in nature. Function warming the kidney to invigorate YANG; Parasite killing detoxifies; Mind calming; Cough-relieving. Main seminal emission; Sexual impotence; Vitiligo; Acute mastitis; Cardiopalmus; Cough.

Radix Pecteilis susannae calls gentle grass (" Kunming conventional medical herbs among the people "), soil Rhizoma Polygonati Odorati, Bai Diehua (" register planted by Guangxi medicine "). For the tuber that orchid tap is blue. Slightly warm in nature, sweet in the mouth. Function warming the kidney to invigorate YANG.

Herba Cynanchi Thesioidis another name female green grass or young crops, angle, mountain, Radix Pachyrhizi Erosi, sheep not milk fruit, little Fructus Luffae, floating wooden dipper, old melon gourd dipper, husky grandmother, horse milk milk, sand Herba Euphorbiae Humifusae, spire cynanchum auriculatum Royle ex Wight, passeris montani saturati melon, arhat grass, Semen Pachyrhizi Erosi, Pueraria lobota, Radix Pachyrhizi Erosi wooden dipper, interwined dragon grass, cattle tip melon, sheep milk is careless, sheep bar milk. Herb for dicotyledon Yao Luo section plant spire Rhizoma Cynanchi Stauntonii. Latin plant animal mineral name: 1.Cynanchumthesioides (Freyn) K.Schum.2.Cynanchumthesioides (Freyn) K.Schum.var.aus-trale (Maxim.) TsiangetP.T.Li [C.sibiricumR.Br.var.aus-traleMaxim.EtKom.]. Sweet in the mouth; Cool in nature. Return lung meridian. Function tonifying the lung gas; Resolving heat and reducing pathogenic fire; Promoting the production of body fluid to quench thirst; Anti-inflammatory analgetic. Main hyperactivity of deficient fire; Have sore throat; Deficiency of both vital energy and Yin; Mental fatigue is forgetful; Fidgets due to deficiency is thirsty; Dizzy insomnia; Puerperal asthenia; Hypogalactia.

Dendrobium densiflorum lindl. another name Radix Et Rhizoma Rhei, Dendrobium denneanum Kerr., dendrobium, derive from the orchid family Dendrobium densiflorum lindl. DendrobiumdensiflorumLindlexWall., be used as medicine with stem. Sweet in the mouth, light, micro-salty, cold in nature. Function nourishing YIN for benefiting the kidney, promoting the production of body fluid to quench thirst. Aranea calentura, impairment of body fluid, xerostomia excessive thirst, weak after being ill.

Herba goodyearae repentis another name silver wire basin, nine layers of lid, Radix primulae sinodenticulatae, little general, lobule is blue or green, Folium Cannabis is blue or green, Trimeresurus stejnegeri, Agkistrodon medicine, point leaf mountain butterfly, the little green grass or young crops of Folium Bambusae, lung hornwart, Rhizoma pinelliae cordatae, Oxyria sinensis Hemsl., silver earring, for the big Herba goodyearae repentis GoodyeraschlechtendalianaReichb.f. of orchid, little Herba goodyearae repentis goodyerarepens (L.) R.Br. [SatyriumrepensL.], the herb of big piebaldism orchid Goodyerabifora (Lindl.) Hook.f. [GeorchisbifloraLindl.] or floss tikka aspidistra GoodyeravelutinaMaxim.. sweet in the mouth, pungent, property is put down. function nourishing the lung to arrest cough, tonify Qi of the kidney, promoting flow of QI and blood, subduing swelling and detoxicating. main pulmonary tuberculosis cough, tracheitis, dizzy weak, neurasthenia, sexual impotence, traumatic injury, arthralgia, laryngopharynx swelling and pain, acute mastitis, furuncle, scrofula, venom.

Radix Habenariae Delavayi another name Radix Satyrii nepalensis, twoflower rattlesnake plantain, thick lobe jade phoenix flower, pairing grass, derive from the orchid family jade phoenix flower plant Radix Habenariae Delavayi HabenariadelavayiFinet, be used as medicine with tuber. Sweet in the mouth, hardship, warm in nature. Function is tonified Qi of the kidney. For lumbago due to renal deficiency, nephritis, hernia, function of nervous system's disease.

Radix Glycyrrhizae is sweet, flat. GUIXIN, lung, spleen, stomach warp. Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription. For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.

TCM Document to type 2 diabetes mellitus complicated hypertension without corresponding name of disease, from its clinical symptoms, " quenching one's thirst " of the type 2 diabetes mellitus correspondence traditional Chinese medical science, the hypertension correspondence traditional Chinese medical science " dizziness ", " headache ", therefore type 2 diabetes mellitus complicated hypertension belongs to the double category seeing dizziness, headache of diabetes. The present inventor sums up working experience, it is believed that type 2 diabetes mellitus complicated hypertension is relevant with yang-energy virtual loss, therefore with QI invigorating warming YANG, the treatment of promoting the production of body fluid to quench thirst method.

The Chinese medicine composition of the present invention, its prescription mechanism is as follows:

Monarch drug: Shan Ta, Radix Pecteilis susannae merit are with QI invigorating warming YANG;

Ministerial drug: Herba Cynanchi Thesioidis, Dendrobium densiflorum lindl. merit are with promoting the production of body fluid to quench thirst;

Adjuvant drug: Herba goodyearae repentis, Radix Habenariae Delavayi merit are to tonify Qi of the kidney;

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share the effect playing QI invigorating warming YANG, promoting the production of body fluid to quench thirst altogether, are applied to type 2 diabetes mellitus complicated hypertension (yang-energy deficiency) patient and can reduce blood glucose and blood pressure level, and TCM syndrome is evident in efficacy, is worthy of popularization.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about the present invention, but and is not so limited the present invention.

Embodiment 1

A kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension, each crude drug weight proportion is as follows:

China fir tower 6g, Radix Pecteilis susannae 6g, Herba Cynanchi Thesioidis 6g, Dendrobium densiflorum lindl. 6g, Herba goodyearae repentis 6g, Radix Habenariae Delavayi 6g, Radix Glycyrrhizae 6g.

Embodiment 2

A kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension, each crude drug weight proportion is as follows:

China fir tower 5g, Radix Pecteilis susannae 7g, Herba Cynanchi Thesioidis 5g, Dendrobium densiflorum lindl. 7g, Herba goodyearae repentis 5g, Radix Habenariae Delavayi 7g, Radix Glycyrrhizae 5g.

Embodiment 3

A kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension, each crude drug weight proportion is as follows:

China fir tower 7g, Radix Pecteilis susannae 5g, Herba Cynanchi Thesioidis 7g, Dendrobium densiflorum lindl. 5g, Herba goodyearae repentis 7g, Radix Habenariae Delavayi 5g, Radix Glycyrrhizae 7g.

Embodiment 4

A kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension, each crude drug weight proportion is as follows:

China fir tower 4g, Radix Pecteilis susannae 8g, Herba Cynanchi Thesioidis 4g, Dendrobium densiflorum lindl. 8g, Herba goodyearae repentis 4g, Radix Habenariae Delavayi 8g, Radix Glycyrrhizae 4g.

Embodiment 5

A kind of Chinese medicine composition treating type 2 diabetes mellitus complicated hypertension, each crude drug weight proportion is as follows:

China fir tower 8g, Radix Pecteilis susannae 4g, Herba Cynanchi Thesioidis 8g, Dendrobium densiflorum lindl. 4g, Herba goodyearae repentis 8g, Radix Habenariae Delavayi 4g, Radix Glycyrrhizae 4g.

The Chinese medicine composition of the present invention has been carried out clinical pharrnacokinetics test, and Details as Follows:

1. data and method

1.1 object of study

Choose type 2 diabetes mellitus complicated hypertension (yang-energy virtual loss card) patient 140 example, wherein male 72 examples, female 68 example, year mean age (54.73 ± 12.54).

1.2 diagnostic criterias

1.2.1 Western medicine diagnose standard:

The diagnostic criteria of type 2 diabetes mellitus diagnosis diagnosis basis WHO diabetes. Fasting glucose (FPG) >=7.0mmol/L; Blood glucose >=11.1mmol/L after glucose load 2h.

" China's hypertension prevention and control guide " revised edition in 2010 that hypertension diagnosis is issued with reference to Ministry of Health of the People's Republic of China, NCCD, hypertension alliance of China, the diagnostic criteria of hypertension is: when not using antihypertensive drugs, non-three blood pressure measurements on the same day, shrink pressure >=140mmHg and (or) diastolic pressure >=90mmHg.

1.2.2 TCM Syndrome Type diagnostic criteria:

Formulate with reference to " Chinese medicine guideline of clinical investigations ", belong to type 2 diabetes mellitus complicated hypertension yang-energy virtual loss card person: primary symptom: polydipsia, limbs fatigue, acra feel cold, edema, frequent urination at night;Secondary disease: tired, limbs fatigue, cardiopalmus, uncomfortable in chest, breathe hard; Tongue vein: light red tongue, plump tongue, thick fur, tongue be greasy, rolling pulse in vain. Primary symptom two+secondary disease two is diagnosable in conjunction with tongue vein.

1.3 inclusive criterias:

(1) one full year of life at age 18～80.

(2) meeting Western medicine diagnose standard, pattern of syndrome belongs to yang-energy virtual loss card person.

(3) sanity, can normal communication.

(4) experimenter's voluntary participation clinical investigation, and sign Informed Consent Form.

1.4 Excluded cases standards:

(1) acute renal failure, end stagerenaldisease;

(2) acute myocardial infarction, acute heart failure;

(3) acute cerebral infarction or cerebral hemorrhage;

(4) type 1 diabetes, gestational diabetes, specific type diabetes;

(5) secondary hypertension;

(6) carotid artery or lower limb atherosclerosis merge speckle, wherein official jargon stenosis rate > 90%, (obturation) person;

(7) malignant tumor patient;

(8) other serious diseases.

The rejecting of 1.5 cases and coming off

(1) therapist can not be adhered to;

(2) therapeutic scheme executor is not pressed;

(3) experimenter of serious adverse events/untoward reaction occurs;

(4) therapeutic process occurs other serious complication or sb.'s illness took a turn for the worse person;

(5) researcher thinks that proceeding test may cause damage to experimenter.

1.6 Therapeutic Method

Giving the treatment by Chinese herbs of the embodiment of the present invention 1, prescription is as follows: China fir tower 6g, Radix Pecteilis susannae 6g, Herba Cynanchi Thesioidis 6g, Dendrobium densiflorum lindl. 6g, Herba goodyearae repentis 6g, Radix Habenariae Delavayi 6g, Radix Glycyrrhizae 6g, is decocted in water for oral dose, day potion, sooner or later sub-service, with 7d for a course for the treatment of.

1.7 observation index

(1) fasting glucose situation of change before and after treatment.

(2) blood pressure situation before and after treatment.

(3) safety detection: include routine blood test, liver function, renal function and electrocardiogram.

1.8 TCM syndrome therapeutic evaluatioies

Evaluation criteria is with reference to " the new Chinese medicine clinical research medication guide principle " of promulgation in 2002.

1. recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.

Computing formula: nimodipine method: integration x100% before (before treatment integration after integration-treatment)/treatment.

1.9 statistical method

SPSS14.0 version statistical software is adopted to be analyzed. Measurement data is added and subtracted standard deviation with mean and is represented, compares employing t inspection before and after treatment, and enumeration data represents with percentage rate, compares employing X 2 test, represent that difference has statistical significance with P < 0.05 before and after treatment.

2. result

Before and after 2.1 treatments, blood glucose and blood pressure compare

Fasting glucose is reduced to (5.73 ± 1.21) mmol/L after treatment by (12.26 ± 3.32) mmol/L before treating, and difference has statistical significance (t=5.483, P < 0.05). Shrinking pressure and be reduced to (109.44 ± 12.43) mmHg after treatment by (159.43 ± 15.65) mmHg before treating, difference has statistical significance (t=5.244, P < 0.05); Diastolic pressure is reduced to (70.87 ± 7.65) mmHg after treatment by (102.43 ± 10.52) mmHg before treating, and difference has statistical significance (t=5.421, P < 0.05);

2.2 clinical efficacies

140 example patient clinical curative effects: cure 129 examples, effective 10 examples, effective 1 example, invalid 0 example.Curative effect: cure rate 92.1%, effective percentage is 100%.

2.3 safety analysiss

Treatment Patients Before And After routine blood test, Liver and kidney merit and electrocardiogram are without significant change, and drug safety is better.

Claims (3)

1. treat a Chinese medicine composition for type 2 diabetes mellitus complicated hypertension, be made up of the Chinese medicine of following weight portion:

China fir tower 4-8 part, Radix Pecteilis susannae 4-8 part, Herba Cynanchi Thesioidis 4-8 part, Dendrobium densiflorum lindl. 4-8 part, Herba goodyearae repentis 4-8 part, Radix Habenariae Delavayi 4-8 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine composition for the treatment of type 2 diabetes mellitus complicated hypertension according to claim 1, it is characterised in that be made up of the Chinese medicine of following weight portion:

China fir tower 5-7 part, Radix Pecteilis susannae 5-7 part, Herba Cynanchi Thesioidis 5-7 part, Dendrobium densiflorum lindl. 5-7 part, Herba goodyearae repentis 5-7 part, Radix Habenariae Delavayi 5-7 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine composition for the treatment of type 2 diabetes mellitus complicated hypertension according to claim 3, it is characterised in that be made up of the Chinese medicine of following weight portion:

6 parts of China fir tower, Radix Pecteilis susannae 6 parts, Herba Cynanchi Thesioidis 6 parts, Dendrobium densiflorum lindl. 6 parts, Herba goodyearae repentis 6 parts, Radix Habenariae Delavayi 6 parts, 6 parts of Radix Glycyrrhizae.