CN105663164A - Preparation method of high-purity bone charcoal powder for preparing medicine - Google Patents
Preparation method of high-purity bone charcoal powder for preparing medicine Download PDFInfo
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- CN105663164A CN105663164A CN201610049303.1A CN201610049303A CN105663164A CN 105663164 A CN105663164 A CN 105663164A CN 201610049303 A CN201610049303 A CN 201610049303A CN 105663164 A CN105663164 A CN 105663164A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
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Abstract
The invention discloses a preparation method of high-purity bone charcoal powder for preparing medicine and relates to the technical field of bone charcoal powder production.The preparation method includes: preliminarily crushing bone blocks, deoiling and degumming, using alum to remove odor, acidifying with acid solution, washing, airing, and grinding to obtain the high-purity bone charcoal powder.The preparation method has the advantages that the method is simple in process flow and reasonable and standard in technical method, the high-purity bone charcoal powder can be prepared normally while the odor of the bone material can be removed through alum solution soaking, the prepared bone charcoal powder is free of odor and toxins through acid solution soaking, high purity of the bone charcoal powder is guaranteed, pollution is avoided, the effective components in the bone charcoal powder are kept, good raw material is provided for medicine preparation, and the application value of the bone charcoal powder is increased.
Description
Technical field
The present invention relates to bone black powder production technical field, it is specifically related to a kind of high purity bone carbon dust preparation method for the preparation of medicine.
Background technology
Bone black powder is the white bulk being insoluble in water, and granularity is greater than 5mm, is rich in the material of the elements such as phosphorus calcium. can be used as pottery, medicine, the additives such as plastics, also polishing agent can be made, metallurgical releasing agent etc., the raw material of bone black is domestic animal bone, its maximum advantage of bone black powder prepares medicine, the hydroxyapatite extracted from bone black, can very effective removal heavy metal, its advantage is that it can eliminate the negative impact of hardness in water, thus eliminate heavy metal, except ion exchange resin, other sorbent materials all do not have this kind of ability, and it is very expensive, test shows, EC-MB bone black can eliminate the arsenide of in water 0.5% and the fluorochemical of 0.5% weight, repeatedly circular treatment can also be carried out, traditional bone black powder just pulverizes preparation by common calcining due to it, when using as medicine material, there is certain limitation line, cause purity low, the effective ingredient of preparation is low.
Summary of the invention:
Technical problem to be solved by this invention is to provide a kind of working method advantages of simple, the high purity bone carbon dust preparation method for the preparation of medicine that active constituent content is high.
Technical problem to be solved by this invention realizes by the following technical solutions:
A kind of high purity bone carbon dust preparation method for the preparation of medicine, it is characterised in that, comprise the following steps:
1) selecting fresh animal bone block, then pulverize, then put into vacuum tank, add distilled water, in control tank, air pressure is 0.01-0.03MPa, temperature 65-80 DEG C, heating 2-2.5h;
2) agitator put into by the aggregate after step 1 being processed, and opens and stirs, and control rotating speed is after 2500-3500r/min, after high-speed stirring 20-30min, sorts, for removing the meat muscle that is attached to bone block surface, earth grind off, obtain clean bone block;
3) aggregate after step 2 being processed loads to be carried in oil cauldron, adds benzene, is led to by the heating coil carried in oil cauldron and constantly heat into steam, water in benzene and aggregate forms benzene, water azeotrope, and through condenser condenses, benzene, water are separated, benzene refluxes mutually to enter and proposes oil cauldron circulation, and aqueous phase is discharged;Until after the water in aggregate taken out of substantially, stopping heating, terminating benzene circulation, taking out aggregate;
4) utilize 1500 DEG C of high temperature, then high pressure to make the ossein in bone block be hydrolyzed into collagen protein, reusable heat water stripping, form glue liquid, adopt negative pressure evaporation to be condensed into dense glue liquid, the bone slag drying screening after coming unstuck;
5) getting a stirred pot, put into distilled water in stirred pot, then will put into alum in distilled water, the aggregate in step 4, until concentration is 8.5-12.1%, is then added wherein by allotment, soaks 3-5h, and period once stirs every 20-30min; The immersion of alum solution, plays the effect that peculiar smell is removed
6) aggregate in step 5 is put into tank, adding citric acid, lactic acid, hydrochloric acid, acetic acid and water and carry out composite acid solution according to the mass ratio of 1:3:2:4:200, open and stir, in control tank, air pressure is 0.02-0.04MPa, temperature 65-80 DEG C, acidolysis after 6-7 hour decrease temperature and pressure go out tank; After acidolysis, de-taste degerming further;
7) getting clear water and put into tank, the aggregate after step 6 being processed is put into wherein, the acid solution of stirring and washing aggregate surface, is then taken out by aggregate and spreads at cool place place, after naturally drying, adopts shredder, carry out grinding to form powder;
8) pulvis after above-mentioned steps 7 being ground can obtain, vacuum packaging after adopting polythene bag packaging vacuum packaging, ensure that rationally it is neatly spent and quality.
Bone block after pulverizing in described step 1 is 1-5cm; It is convenient to following process operation.
Bone meal particle diameter after grinding in described step 7 is 0.2-0.3mm, and quality is fine and smooth, purity height.
Described step 6 citric acid concentration is 45-50%, described lactic acid concn 20-35%, and described concentration of hydrochloric acid is 15-25%, and described acetate concentration is 10-15%.
The invention has the beneficial effects as follows: technical process of the present invention is succinct, technological method reasonable standard, be possible not only to normal preparation high-purity bone black powder, simultaneously by the immersion of alum solution, ensure that the removal of aggregate self peculiar smell, soaked by acid solution, ensure that the bone black powder free from extraneous odour after preparation is without toxin, ensure that the high purity in bone meal, pollution-free, ensure that the reservation of the effective constituent in the bone black powder after preparation, avoid running off, for medicine preparation provides good starting material, thus improve the using value of bone black powder.
Embodiment
In order to the present invention is realized technique means, creation characteristic, reach object and effect is easy to understand, below in conjunction with specific embodiment, set forth the present invention further.
Embodiment 1
For the preparation of a high purity bone carbon dust preparation method for medicine, comprise the following steps:
1) selecting fresh animal bone block, then pulverize, then put into vacuum tank, add distilled water, in control tank, air pressure is 0.01MPa, temperature 65 DEG C, heating 2h;
2) agitator put into by the aggregate after step 1 being processed, and opens and stirs, and control rotating speed is after 2500r/min, after high-speed stirring 20min, sorts, for removing the meat muscle that is attached to bone block surface, earth grind off, obtain clean bone block;
3) aggregate after step 2 being processed loads to be carried in oil cauldron, adds benzene, is led to by the heating coil carried in oil cauldron and constantly heat into steam, water in benzene and aggregate forms benzene, water azeotrope, and through condenser condenses, benzene, water are separated, benzene refluxes mutually to enter and proposes oil cauldron circulation, and aqueous phase is discharged; Until after the water in aggregate taken out of substantially, stopping heating, terminating benzene circulation, taking out aggregate;
4) utilize 1500 DEG C of high temperature, then high pressure to make the ossein in bone block be hydrolyzed into collagen protein, reusable heat water stripping, form glue liquid, adopt negative pressure evaporation to be condensed into dense glue liquid, the bone slag drying screening after coming unstuck;
5) getting a stirred pot, put into distilled water in stirred pot, then will put into alum in distilled water, the aggregate in step 4, until concentration is 8.5%, is then added wherein by allotment, soaks 3h, and period once stirs every 20min; The immersion of alum solution, plays the effect that peculiar smell is removed
6) aggregate in step 5 is put into tank, adding citric acid, lactic acid, hydrochloric acid, acetic acid and water and carry out composite acid solution according to the mass ratio of 1:3:2:4:200, open and stir, in control tank, air pressure is 0.02MPa, temperature 65 DEG C, acidolysis after 6 hours decrease temperature and pressure go out tank; After acidolysis, de-taste degerming further;
7) getting clear water and put into tank, the aggregate after step 6 being processed is put into wherein, the acid solution of stirring and washing aggregate surface, is then taken out by aggregate and spreads at cool place place, after naturally drying, adopts shredder, carry out grinding to form powder;
8) pulvis after above-mentioned steps 7 being ground can obtain, vacuum packaging after adopting polythene bag packaging vacuum packaging, ensure that rationally it is neatly spent and quality.
Embodiment 2
For the preparation of a high purity bone carbon dust preparation method for medicine, comprise the following steps:
1) selecting fresh animal bone block, then pulverize, then put into vacuum tank, add distilled water, in control tank, air pressure is 0.03MPa, temperature 80 DEG C, heating 2.5h;
2) agitator put into by the aggregate after step 1 being processed, and opens and stirs, and control rotating speed is after 3500r/min, after high-speed stirring 30min, sorts, for removing the meat muscle that is attached to bone block surface, earth grind off, obtain clean bone block;
3) aggregate after step 2 being processed loads to be carried in oil cauldron, adds benzene, is led to by the heating coil carried in oil cauldron and constantly heat into steam, water in benzene and aggregate forms benzene, water azeotrope, and through condenser condenses, benzene, water are separated, benzene refluxes mutually to enter and proposes oil cauldron circulation, and aqueous phase is discharged; Until after the water in aggregate taken out of substantially, stopping heating, terminating benzene circulation, taking out aggregate;
4) utilize 1500 DEG C of high temperature, then high pressure to make the ossein in bone block be hydrolyzed into collagen protein, reusable heat water stripping, form glue liquid, adopt negative pressure evaporation to be condensed into dense glue liquid, the bone slag drying screening after coming unstuck;
5) getting a stirred pot, put into distilled water in stirred pot, then will put into alum in distilled water, the aggregate in step 4, until concentration is 12.1%, is then added wherein by allotment, soaks 5h, and period once stirs every 30min; The immersion of alum solution, plays the effect that peculiar smell is removed
6) aggregate in step 5 is put into tank, adding citric acid, lactic acid, hydrochloric acid, acetic acid and water and carry out composite acid solution according to the mass ratio of 1:3:2:4:200, open and stir, in control tank, air pressure is 0.04MPa, temperature 80 DEG C, acidolysis after 7 hours decrease temperature and pressure go out tank; After acidolysis, de-taste degerming further;
7) getting clear water and put into tank, the aggregate after step 6 being processed is put into wherein, the acid solution of stirring and washing aggregate surface, is then taken out by aggregate and spreads at cool place place, after naturally drying, adopts shredder, carry out grinding to form powder;
8) pulvis after above-mentioned steps 7 being ground can obtain, vacuum packaging after adopting polythene bag packaging vacuum packaging, ensure that rationally it is neatly spent and quality.
More than show and describe the ultimate principle of the present invention and the advantage of main characteristic sum the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; the principle that the present invention is just described described in above-described embodiment and specification sheets; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention. The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (4)
1. the high purity bone carbon dust preparation method for the preparation of medicine, it is characterised in that, comprise the following steps:
1) selecting fresh animal bone block, then pulverize, then put into vacuum tank, add distilled water, in control tank, air pressure is 0.01-0.03MPa, temperature 65-80 DEG C, heating 2-2.5h;
2) agitator put into by the aggregate after step 1 being processed, and opens and stirs, and control rotating speed is after 2500-3500r/min, after high-speed stirring 20-30min, sorts, obtains clean bone block;
3) aggregate after step 2 being processed loads to be carried in oil cauldron, adds benzene, is led to by the heating coil carried in oil cauldron and constantly heat into steam, water in benzene and aggregate forms benzene, water azeotrope, and through condenser condenses, benzene, water are separated, benzene refluxes mutually to enter and proposes oil cauldron circulation, and aqueous phase is discharged; Until after the water in aggregate taken out of substantially, stopping heating, terminating benzene circulation, taking out aggregate;
4) utilize 1500 DEG C of high temperature, then high pressure to make the ossein in bone block be hydrolyzed into collagen protein, reusable heat water stripping, form glue liquid, adopt negative pressure evaporation to be condensed into dense glue liquid, the bone slag drying screening after coming unstuck;
5) getting a stirred pot, put into distilled water in stirred pot, then will put into alum in distilled water, the aggregate in step 4, until concentration is 8.5-12.1%, is then added wherein by allotment, soaks 3-5h, and period once stirs every 20-30min;
6) aggregate in step 5 is put into tank, adding citric acid, lactic acid, hydrochloric acid, acetic acid and water and carry out composite acid solution according to the mass ratio of 1:3:2:4:200, open and stir, in control tank, air pressure is 0.02-0.04MPa, temperature 65-80 DEG C, acidolysis after 6-7 hour decrease temperature and pressure go out tank;
7) getting clear water and put into tank, the aggregate after step 6 being processed is put into wherein, the acid solution of stirring and washing aggregate surface, is then taken out by aggregate and spreads at cool place place, after naturally drying, adopts shredder, carry out grinding to form powder;
8) pulvis after above-mentioned steps 7 being ground can obtain after adopting polythene bag packaging vacuum packaging.
2. a kind of high purity bone carbon dust preparation method for the preparation of medicine according to claim 1, it is characterised in that: the bone block after the pulverizing in described step 1 is 1-5cm.
3. a kind of bone carbon dust preparation method strong for the preparation of the fixing degree of sclerotin porcelain according to claim 1, it is characterised in that: the bone meal particle diameter after grinding in described step 7 is 0.2-0.3mm.
4. a kind of bone carbon dust preparation method strong for the preparation of the fixing degree of sclerotin porcelain according to claim 1, it is characterized in that: described step 6 citric acid concentration is 45-50%, described lactic acid concn 20-35%, described concentration of hydrochloric acid is 15-25%, and described acetate concentration is 10-15%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610049303.1A CN105663164A (en) | 2016-01-22 | 2016-01-22 | Preparation method of high-purity bone charcoal powder for preparing medicine |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610049303.1A CN105663164A (en) | 2016-01-22 | 2016-01-22 | Preparation method of high-purity bone charcoal powder for preparing medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108751944A (en) * | 2018-06-13 | 2018-11-06 | 安徽省淮河制胶有限公司 | A kind of preparation method of bone carbon dust |
| CN109054925A (en) * | 2018-06-13 | 2018-12-21 | 安徽省淮河制胶有限公司 | A kind of preparation method of release agent bone carbon dust |
Citations (3)
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| CN1310151A (en) * | 2000-07-11 | 2001-08-29 | 张仁良 | Black animal charcoal, black animal charcoal meal and their production process |
| CN103738937A (en) * | 2013-12-24 | 2014-04-23 | 安徽省淮河制胶有限公司 | Production process for bone black powder |
| CN103740283A (en) * | 2013-12-24 | 2014-04-23 | 安徽省淮河制胶有限公司 | Preparation method for producing industrial gum via animal bones |
-
2016
- 2016-01-22 CN CN201610049303.1A patent/CN105663164A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310151A (en) * | 2000-07-11 | 2001-08-29 | 张仁良 | Black animal charcoal, black animal charcoal meal and their production process |
| CN103738937A (en) * | 2013-12-24 | 2014-04-23 | 安徽省淮河制胶有限公司 | Production process for bone black powder |
| CN103740283A (en) * | 2013-12-24 | 2014-04-23 | 安徽省淮河制胶有限公司 | Preparation method for producing industrial gum via animal bones |
Non-Patent Citations (4)
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| 任红敏等: "畜禽骨的研究现状和发展前景", 《农产品加工·学刊》 * |
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| 阿依江·达吾列提: "羊、牛骨炭的制备及对Hg(II)吸附性能研究", 《中国优秀硕士学位论文全文数据库工程科技I辑》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108751944A (en) * | 2018-06-13 | 2018-11-06 | 安徽省淮河制胶有限公司 | A kind of preparation method of bone carbon dust |
| CN109054925A (en) * | 2018-06-13 | 2018-12-21 | 安徽省淮河制胶有限公司 | A kind of preparation method of release agent bone carbon dust |
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Application publication date: 20160615 |