CN105662439A - Collection device dedicated for arterial blood sample of mouse - Google Patents
Collection device dedicated for arterial blood sample of mouse Download PDFInfo
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- CN105662439A CN105662439A CN201610156259.4A CN201610156259A CN105662439A CN 105662439 A CN105662439 A CN 105662439A CN 201610156259 A CN201610156259 A CN 201610156259A CN 105662439 A CN105662439 A CN 105662439A
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- pipe joint
- blood sample
- duct
- needle stand
- mouse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
Abstract
The invention relates to a collection device dedicated for an arterial blood sample of a mouse. The collection device comprises a blood sample drawing device, a puncturing component and a needle stand cover; the puncturing component is arranged on the needle stand cover; the needle stand cover is connected with the blood sample drawing device; the puncturing component is a thin and soft catheter. When the collection device is used, after being subjected to general anesthesia, the mouse is fixed on a mouse board; a common carotid artery is separated and exposed; the common carotid artery is cut to form a centripetal incision forming an angle of 30 to 45 degrees relative to a blood vessel; the thin and soft catheter is inserted into the artery from the incision to a cardiac direction to draw arterial blood of required amount. As the thin and soft catheter is adopted to puncture the blood vessel, the collection device cannot penetrate through an arterial wall; the collection device is safe, simple and convenient to operate; moreover, the thin and soft catheter can be conveniently retained and fixed in the body of a laboratory animal, so that the arterial blood can be conveniently collected repeatedly.
Description
Technical field
The present invention relates to be exclusively used in mouse arterial blood sample harvester.
Background technology
Mouse has become widely used animal used as test in biomedical research at present, in the Ye Shi world today, the most detailed mammality animal used as test of research, is usually used in the research in the fields such as science of heredity and genetic disease, oncology, communicable disease, medicine, immunology, endocrine system disease, geratology. Along with being on the rise of global climate problem, the morbidity of correlative study confirmation atmosphere pollution and breathing problem, angiocardiopathy is close, internal authority magazine JAMA in 2012 confirms that air pollution is a risks and assumptions of angiocardiopathy, therefore also more and more at respiratory tract, research aspect cardiovascular. With mouse the animal models such as duplicated chronic bronchopneumonia, acute pulmonary edema, bronchial astehma, chronic pulmonary hypertension, pulmonary fibrosis become the basis of research breathing problem mechanism. We,, carrying out in the experiment of Respiratory Tract of Mice disease model, often need to gather arterial blood to mouse and carry out arterial blood gas analysis.
Look back data of literatures, we gather mouse arterial blood for blood gas analysis at present, great majority are all by from disconnected arteria coeliaca, then quick suction blood, or from disconnected mouse RCCA, or by 1ml syringe acupuncture intravital mouse heart suction arterial blood, or open the blood sampling of brooch thorn right ventricle. The shortcoming of these three kinds of methods: 1, for directly gathering artery method from disconnected or acupuncture arteria coeliaca: mouse peritoneal artery is positioned at rear, abdominal cavity, position is darker, need fully to expose mouse peritoneal, pass intestinal tube, manifest posterior wall of abdomen, remove retroperitoneal adipose tissue, just can see abdominal aorta, so large wound operation, can affect the respiratory function of mouse, and then affect the accuracy of mouse ABG; From suction blood fast after disconnected arteria coeliaca, arterial blood directly contacts with air, understands the accuracy that directly affect the important blood gas indexes such as partial pressure of oxygen, blood oxygen saturation, partial pressure of carbon dioxide. 2, syringe puncture intravital mouse heart is adopted to arterial blood shortcoming: 1. mouse heart is little, 470-480 time/min of heart rate, heart blood sampling is more difficult, and technical requirement is high, the operating process small mouse death rate is higher, is not suitable for arterial blood to have the experimental study of strict demand; 2. can not ensure collected is arterial blood completely, also can extraction arteriovenous mix blood because of direction or the operational issue of inserting needle, can cause art pO2 and oxygen saturation obviously abnormal. 3, split brooch thorn right ventricle: if open once dead blood sampling of chest, one opens thoracic cavity, has cut off the respiratory function of mouse completely, not gathering before arterial blood, can there is significant change in the index of correlation of ABG, affect the accuracy of experimental data.
To sum up, there is many deficiencies in the method that existing mouse arterial blood adopts, and adopts the problems such as conventional syringe is carried out, and because mouse heart, artery etc. are less, technical requirement is high, and the operating process small mouse death rate is higher for the collection of mouse arterial blood sample simultaneously.
Summary of the invention
Objects of the present invention: the defect existing for overcoming prior art, the invention provides that a kind of blood specimen collection is easy and simple to handle, safety, little on mouse impact, blood sample disturbs few, and testing result is exclusively used in mouse arterial blood sample harvester accurately.
For achieving the above object, the invention provides following technical scheme:
One is exclusively used in mouse arterial blood sample harvester, comprises blood sample draw-out device, lancet and means and needle stand cover, and lancet and means is located at needle stand and is put, and needle stand cover is connected with blood sample draw-out device, it is characterized in that: described lancet and means is soft conduit.
Arterial blood sample harvester using method of the present invention is, forms otch, more soft conduit is punctured in blood vessel along otch on blood vessel, can be by the operation of taking a blood sample of blood sample draw-out device. Adopt soft conduit to substitute traditional puncture of steel needles, due to the flexibility of soft conduit, in piercing process, blood vessel can not penetrated, ensure the stability (avoiding dead mouse) of animal used as test, operate more easyly, technical requirement is low, the reduction operating time; And soft conduit is convenient to retain and is fixed on animal used as test health, the convenient arterial blood that repeatedly gathers.
Preferably, described blood sample draw-out device is the vacuum type blood sample draw-out device with vacuum.
Under said structure, blood sample draw-out device has vacuum, can reduce arterial blood sample ingress of air as far as possible, thereby improves the arterial blood sample degree of purity collecting, and improves testing result accuracy.
Preferably, described blood sample draw-out device comprises pipeline switching control valve, forevacuum suction syringe and blood-drawing syringe, described pipeline switching control valve comprises valve body, on valve body, there is the first pipe joint, the second pipe joint, the 3rd pipe joint, in the valve pocket of valve body, be provided with the spool of control valve joint conducting between two, spool is connected with the operating parts that drives its position to switch, described blood-drawing syringe is inserted on the first pipe joint with removably, forevacuum suction syringe is installed on the second pipe joint, and described soft conduit is connected on the 3rd pipe joint through needle stand cover.
The blood sample draw-out device operation principle of said structure is: spool control the first pipe joint and the second pipe joint conducting, conducting between forevacuum suction syringe and blood-drawing syringe, use forevacuum suction syringe by respective air suction in blood-drawing syringe and pipeline switching control valve, make blood-drawing syringe in forevacuum state, the first pipe joint of spool control afterwards and the 3rd pipe joint conducting, can draw blood by blood-drawing syringe and soft conduit; Because the air in blood-drawing syringe and corresponding pipeline switching control valve is extracted out and formed forevacuum by forevacuum suction syringe, thereby can lower the impact of air on arterial blood sample, improve the degree of purity of sample, improve testing result accuracy. And because the arterial pressure of mouse is limited, adopt syringe to extract the arterial blood of animal used as test, and aspirating by external force, blood sample extracts and gathers reliably; And after syringe blood sample collection, in the later stage, blood sample is placed in to operation on checkout equipment also more for convenience.
Preferably, described spool comprises that rotary dynamic seal is matched with the spool body in valve pocket, in spool body, be provided with the first duct, the second duct and the 3rd duct, the first duct, the second duct and the 3rd duct one port are the outer aperture that runs through spool body surface, the first duct, the second duct and the 3rd another port, duct converge at spool body interior mutual UNICOM, on the side face of described spool body, also having can the wherein sealing surface of a pipe joint of shutoff, and sealing surface, the first duct, the second duct and the 3rd duct are along circumferentially uniform.
Under said structure design, when operation, by two pipe joint places that wherein the outer aperture correspondence in two ducts is communicated with at needs, the remaining pipe joint place that sealing surface is corresponding, controls wherein two pipe joints connections thereby realize, simple in structure, easy to operate; And spool can be urged to the second pipe joint, the 3rd pipe joint conduction position, and make this device operated in common blood sampling, can realize double syringe use, expand the scope of application.
Preferably, described the first pipe joint and the 3rd pipe joint are positioned on same linear position, and the second pipe joint is between the first pipe joint and the 3rd pipe joint.
Under said structure design, in the time that the sealing surface of operation spool seals the 3rd pipe joint and the second pipe joint, its position is adjacent, and operating distance is short, easy to operate.
Preferably, described operating parts comprises the central part of corresponding spool body pivot, the moving arm of the corresponding sealing surface of central part side direction, and moving arm radially extends.
Under said structure design, operating parts is simple in structure, and its moving arm can be indicated valve body closed position, again can convenient operation.
Preferably, described soft conduit is connected with needle stand cover, needle stand cover coordinates with the 3rd pipe joint socket, the outer wall of needle stand cover is laterally extending interlocking lug, the outer movable sleeve of the 3rd pipe joint is provided with lock tube, and the 3rd pipe joint is provided with the backstop convex tendon that prevents that lock tube from skidding off, and backstop convex tendon and lock tube are spacing along the 3rd pipe joint length direction backstop, lock tube inner hole wall is provided with spiral locking convex tendon, spiral locking convex tendon and interlocking lug backstop interlocking.
Under said structure design, soft conduit adopts needle stand cover to removably connect with pipeline switching control valve, when connection, needle stand cover is socketed on the 3rd pipe joint, operation lock tube, makes the spiral locking convex tendon in lock tube be affixed on interlocking lug, rotation lock tube, interlocking lug is screwed in and the interlock of locking convex tendon, thereby reach by the locking of needle stand cover on the 3rd pipe joint detachable, reverse rotation lock tube, remove the locking to needle stand cover, can extract needle stand cover; Ensure that soft conduit is fixing reliable and detachably easy to operate, be convenient to soft conduit and stay on experimental animal.
Preferably, described needle stand puts and is provided with a pair of interlocking lug that is positioned opposite, and described lock tube inner hole wall is provided with two spiral locking convex tendons, and two spiral locking convex tendons distribute alternately, article two, between spiral locking convex tendon, form two helicla flutes, interlocking lug and two helicla flutes corresponding matching one by one.
Under said structure design, realize 2 lockings, more firm stable of the locking of needle stand pipe, and form two helicla flutes under the design of double helix locking convex tendon, interlocking lug screws in two helicla flutes, article two, spiral locking convex tendon is realized the both direction backstop locking on interlocking lug the 3rd pipe joint length direction, and needle stand pipe is fixing more solid and reliable.
Preferably, in the passage of described needle stand cover, be placed with solid-state anti-coagulants.
Under said structure design, solid-state anti-coagulants can effectively anti-hemostasis-coagulation, and solid-state anti-coagulants is put in needle stand cover, can make as early as possible the blood sample extracting contact with anti-coagulants, and the sample that guarantee is drawn blood reaches technical requirement; On the other hand, the placement location of solid-state anti-coagulants rationally, conveniently, also can not impact the operation of other parts, as the vacuum pumping of blood sample draw-out device.
Below in conjunction with accompanying drawing, the invention will be further described.
Brief description of the drawings
Fig. 1 be the specific embodiment of the invention one be exclusively used in mouse arterial blood sample harvester structural representation;
Fig. 2 is the structural representation after the spool of pipeline switching control valve of the specific embodiment of the invention one and valve body decompose;
Fig. 3 is that the 3rd pipe joint of the specific embodiment of the invention one coordinates schematic diagram with needle stand cover;
Fig. 4 is specific embodiment of the invention needle stand cover (being with soft conduit) internal structure schematic diagram;
Fig. 5 is exclusively used in mouse arterial blood sample harvester structural representation in the specific embodiment of the invention two.
Detailed description of the invention
Referring to accompanying drawing 1 to accompanying drawing 4, one disclosed by the invention is exclusively used in mouse arterial blood sample harvester, comprises blood sample draw-out device 1, lancet and means 2 and needle stand cover 21, and lancet and means 2 is located on needle stand cover 21, needle stand cover 21 is connected with blood sample draw-out device 1, and described lancet and means 2 is soft conduit. Soft conduit can adopt PE pipe, and using method is as follows, first by after mouse general anesthesia, is fixed on mouse plate; Cut off right side of mice skin of neck, separate along breastbone papillary muscle leading edge and separate the connective tissue between sternohyoideus and sternothyroid, be scarlet arteria carotis communis of beating other can the seeing of right side tracheae; Separate the Carotid nerve of companion's row, isolate the arteria carotis communis of certain length (about 1cm) thereupon, under it, wear two rhizoid lines for subsequent use; At isolated Carotid distal end, with silk thread by artery ligation, at Carotid proximal part, artery is clamped with artery clamp, in between the two, another silk thread for subsequent use is made a call to a knot, mouse plate is moved on to below disecting microscope workbench, be the centripetal otch at 30-45 DEG C of angle with blood vessel cutting one near ligation place of distal end; The soft conduit 2 of blood-taking device is inserted in artery to heart direction by otch, fix with silk thread ligation for subsequent use, open artery clamp, extract the arterial blood of aequum, after extraction, the arterial blood in blood sampling apparatus is sealed to blood sample immediately. Gather the method for arterial blood to being previously correlated with, otch at mouse neck is little, stress and affect little on respiratory function on mouse is traumatic, the blood sample gathering is pure arterial blood, avoid venous blood to sneak into the impact on experimental result, can obtain more accurately experimental data, in blood sampling apparatus, adopt soft conduit to insert artery from arteriotomy puncture, the fine coupling arteria carotis communis of energy, can not penetrate arterial wall, ensures the security and stability of animal used as test, and easy and simple to handle, technical requirement is low, and whole operating process only needs 3 to 4 minutes, the shortening time; And soft conduit is convenient to retain and is fixed on animal used as test health, the convenient arterial blood that repeatedly gathers. Avoid the conventional syringe artery that directly punctures, and mouse artery is thinner, directly enters artery with syringe puncture, the as easy as rolling off a log artery that penetrates, thus cause the animal death of losing blood, the problem of less stable.
Described blood sample draw-out device 1 is the vacuum type blood sample draw-out device with vacuum. Blood sample draw-out device has vacuum, can reduce arterial blood sample ingress of air as far as possible, thereby improves the arterial blood sample degree of purity collecting, and improves testing result accuracy. It can adopt structure as shown in Figure 5, adopt vacuum tube 91 to coordinate double needle design, wherein a syringe needle 92 is draw point, be convenient to thrust the soft rubber stopper 93 of pin blank pipe, another stature is described soft conduit 2, rely on the vacuum in vacuum tube to realize blood drawing, but because the arterial pressure of mouse is little, vacuum hemospasia existence and stability and the blood volume of vacuum tube are difficult to ensure card. Therefore adopt following design:
Described blood sample draw-out device 1 comprises pipeline switching control valve 11, forevacuum suction syringe 12 and blood-drawing syringe 13, described pipeline switching control valve 11 comprises valve body 111, on valve body 110, there is the first pipe joint 111, the second pipe joint 112, the 3rd pipe joint 113, in the valve pocket of valve body 110, be provided with the spool 114 of control valve joint conducting between two, spool 114 is connected with the operating parts 115 that drives its position to switch, described blood-drawing syringe 13 is inserted on the first pipe joint 111 with removably, forevacuum suction syringe 12 is installed on the second pipe joint 112, forevacuum suction syringe 12 can be detachable with the second pipe joint 112, also can be one of the forming, consider accessory processing, deposit, ease of use etc., preferably adopt design for disassembly, described soft conduit 2 is connected on the 3rd pipe joint 113 through needle stand cover 21, needle stand cover 21 can be fixedly connected with one inseparable with soft conduit 2, also can adopt socket connection separable. blood sample draw-out device operation principle is: spool 114 is controlled the first pipe joint 111 and the second pipe joint 112 conductings, conducting between forevacuum suction syringe 12 and blood-drawing syringe 13, use forevacuum suction syringe 12 by blood-drawing syringe 13 and the interior respective air suction of pipeline switching control valve 11, make blood-drawing syringe 13 in forevacuum state, spool 114 is controlled the first pipe joint 111 and the 3rd pipe joint 113 conductings afterwards, can draw blood by blood-drawing syringe 13 and soft conduit 2, because the air in blood-drawing syringe and corresponding pipeline switching control valve is extracted out and formed forevacuum by forevacuum suction syringe, thereby can lower the impact of air on arterial blood sample, improve the degree of purity of sample, improve testing result accuracy. and because the arterial pressure of mouse is limited, adopt syringe to extract the arterial blood of animal used as test, and aspirating by external force, blood sample extracts and gathers reliably.
Preferably, described spool 114 comprises that rotary dynamic seal is matched with the spool body in valve pocket, in spool body, be provided with the first duct 1141, the second duct 1142 and the 3rd duct 1143, the first duct 1141, the second duct 1142 and the 3rd duct 1,143 one ports are the outer aperture that runs through spool body surface, the first duct 1141, the second duct 1142 and 1143 another port, the 3rd duct converge at spool body interior mutual UNICOM, on the side face of described spool body, also having can the wherein sealing surface of a pipe joint of shutoff, sealing surface, the first duct 1141, the second duct 1142 and the 3rd duct 1143 are along circumferentially uniform. described the first pipe joint 111 and the 3rd pipe joint 113 are positioned on same linear position, and the second pipe joint 112 is between the first pipe joint 111 and the 3rd pipe joint 113. in the time of operation, by two pipe joint places that wherein the outer aperture correspondence in two ducts is communicated with at needs, the remaining pipe joint place that sealing surface is corresponding, controls wherein two pipe joints connections thereby realize, simple in structure, easy to operate, and spool can be urged to the second pipe joint, the 3rd pipe joint conduction position, and make this device operated in common blood sampling, can realize double syringe use, expand the scope of application. in the time that the sealing surface of operation spool seals the 3rd pipe joint and the second pipe joint, its position is adjacent, and operating distance is short, easy to operate. put in place reliably for ensureing that spool position switches, between valve body and spool, be provided with shift structure, shift structure comprises along the positioning convex circumferentially distributing and the detent coordinating with it, realizes gear and determine in positioning convex embedding detent, preferred detent is located on spool, and positioning convex is located in valve body.
Certainly as the feasible scheme of the present invention, spool can be engaged in the valve pocket of valve body by longitudinally-moving, on spool, establish the passage that twice longitudinally independently distribute, upper channel has the mouth of corresponding the first pipe joint and the second pipe joint, and lower channel has the mouth of corresponding the first pipe joint and the 3rd pipe joint, and spool has two positions, in the time vacuumizing, corresponding the first pipe joint of upper channel and the second pipe joint position, by its conducting, realize vacuum pumping; Press afterwards spool, make corresponding the first pipe joint of lower channel and the 3rd pipe joint, by its conducting, realize blood drawing operation. Can also be, on spool, establish two ducts, two duct one ports are the outer aperture that connects spool face, two another port, ducts converge in spool and are communicated with, two ducts form a folding shape passage, spool screws in valve body, corresponding the first pipe joint in two outer apertures and the 3rd pipe joint of folding shape passage, and switch to corresponding the first pipe joint and the 3rd pipe joint.
Use for ease of operation, described operating parts 115 comprises the central part 1151 of corresponding spool body pivot, the moving arm 1152 of the corresponding sealing surface of central part 1151 side direction, and moving arm 1152 radially extends. The 3rd instruction unit 1155, the first instruction units 1153, the second instruction unit 1154, the 3rd instruction unit 1155 and moving arm 1152 that the central part of operating parts 115 is also provided with second instruction unit 1154 in first instruction unit 1153 in 1141 upper outside apertures, corresponding the first duct, 1142 upper outside apertures, corresponding the second duct, 1143 upper outside apertures, corresponding the 3rd duct are spacedly distributed. Operating parts is simple in structure, and its moving arm can be indicated valve body closed position, again can convenient operation.
Wherein, needle stand cover 21 can be one-body molded with blood sample draw-out device 1, also can be fixedly connected with integral inseparablely, also can be detachable and coordinate. For ease of using, described needle stand cover 21 coordinates with the 3rd pipe joint 113 sockets, the outer wall of needle stand cover 21 is laterally extending interlocking lug 211, the outer movable sleeve of the 3rd pipe joint 113 is provided with lock tube 14, the 3rd pipe joint 113 is provided with the backstop convex tendon 1131 that prevents that lock tube 14 from skidding off, backstop convex tendon 1131 is spacing along the 3rd pipe joint 113 length direction backstops with lock tube 14, and lock tube 14 inner hole walls are provided with spiral locking convex tendon 141, spiral locking convex tendon 141 and interlocking lug 211 backstop interlockings. Soft conduit adopts needle stand cover to removably connect with pipeline switching control valve, when connection, needle stand cover is socketed on the 3rd pipe joint to operation lock tube, make the spiral locking convex tendon in lock tube be affixed on interlocking lug, rotation lock tube, screws in and the interlock of locking convex tendon interlocking lug, thereby reaches the locking of needle stand cover on the 3rd pipe joint, detachable, reverse rotation lock tube, removes the locking to needle stand cover, can extract needle stand cover; Ensure that soft conduit is fixing reliable and detachably easy to operate, be convenient to soft conduit and stay on experimental animal.
Further, described needle stand cover 21 is provided with a pair of interlocking lug 211a, the 211b that is positioned opposite, described lock tube 14 inner hole walls are provided with two spiral locking convex tendon 141a, 141b, article two, spiral locking convex tendon distributes alternately, article two, between spiral locking convex tendon 141a, 141b, form two helicla flute 142a, 142b, interlocking lug 211a, 211b and two helicla flute 142a, 142b corresponding matching one by one. Realize 2 lockings, more firm stable of the locking of needle stand pipe, and form two helicla flutes under the design of double helix locking convex tendon, interlocking lug screws in two helicla flutes, article two, spiral locking convex tendon is realized the both direction backstop locking on interlocking lug the 3rd pipe joint length direction, and needle stand pipe is fixing more solid and reliable. Be provided with anti-skidding burr at lock tube outer surface, be convenient to rotation operation lock tube.
Whether blood coagulation is a key factor that affects Results of Blood-gas to arterial blood sample, for improving the accuracy of Results of Blood-gas, adopts anti-coagulants, as liquaemin. For in order to be effective and better equipment use applicable of the present invention, in the passage of described needle stand cover 21, be placed with solid-state anti-coagulants 3. Solid-state anti-coagulants is put in needle stand cover, can make as early as possible the blood sample extracting contact with anti-coagulants, ensures that the sample of blood drawing reaches technical requirement; On the other hand, the placement location of solid-state anti-coagulants rationally, conveniently, also can not impact the operation of other parts, as the vacuum pumping of blood sample draw-out device.
Claims (9)
1. be exclusively used in a mouse arterial blood sample harvester, comprise blood sample draw-out device, lancet and means and needle stand cover, lancet and means is located at needle stand and is put, and needle stand cover is connected with blood sample draw-out device, it is characterized in that: described lancet and means is soft conduit.
2. be exclusively used according to claim 1 mouse arterial blood sample harvester, it is characterized in that: described blood sample draw-out device is the vacuum type blood sample draw-out device with vacuum.
3. be exclusively used according to claim 2 mouse arterial blood sample harvester, it is characterized in that: described blood sample draw-out device comprises pipeline switching control valve, forevacuum suction syringe and blood-drawing syringe, described pipeline switching control valve comprises valve body, on valve body, there is the first pipe joint, the second pipe joint, the 3rd pipe joint, in the valve pocket of valve body, be provided with the spool of control valve joint conducting between two, spool is connected with the operating parts that drives its position to switch, described blood-drawing syringe is inserted on the first pipe joint with removably, forevacuum suction syringe is installed on the second pipe joint, described soft conduit is connected on the 3rd pipe joint through needle stand cover.
4. be exclusively used according to claim 3 mouse arterial blood sample harvester, it is characterized in that: described spool comprises that rotary dynamic seal is matched with the spool body in valve pocket, in spool body, be provided with the first duct, the second duct and the 3rd duct, the first duct, the second duct and the 3rd duct one port are the outer aperture that runs through spool body surface, the first duct, the second duct and the 3rd another port, duct converge at spool body interior mutual UNICOM, on the side face of described spool body, also having can the wherein sealing surface of a pipe joint of shutoff, sealing surface, the first duct, the second duct and the 3rd duct are along circumferentially uniform.
5. be exclusively used according to claim 4 mouse arterial blood sample harvester, it is characterized in that: described the first pipe joint and the 3rd pipe joint are positioned on same linear position, the second pipe joint is between the first pipe joint and the 3rd pipe joint.
6. according to being exclusively used in mouse arterial blood sample harvester described in claim 4 or 5, it is characterized in that: described operating parts comprises the central part of corresponding spool body pivot, the moving arm of the corresponding sealing surface of central part side direction, moving arm radially extends.
7. be exclusively used in mouse arterial blood sample harvester according to described in claim 3 or 4 or 5, it is characterized in that: described needle stand cover coordinates with the 3rd pipe joint socket, the outer wall of needle stand cover is laterally extending interlocking lug, the outer movable sleeve of the 3rd pipe joint is provided with lock tube, the 3rd pipe joint is provided with the backstop convex tendon that prevents that lock tube from skidding off, backstop convex tendon and lock tube are spacing along the 3rd pipe joint length direction backstop, and lock tube inner hole wall is provided with spiral locking convex tendon, spiral locking convex tendon and interlocking lug backstop interlocking.
8. be exclusively used according to claim 7 mouse arterial blood sample harvester, it is characterized in that: described needle stand puts and is provided with a pair of interlocking lug that is positioned opposite, described lock tube inner hole wall is provided with two spiral locking convex tendons, article two, spiral locking convex tendon distributes alternately, article two, between spiral locking convex tendon, form two helicla flutes, interlocking lug and two helicla flutes corresponding matching one by one.
9. be exclusively used in mouse arterial blood sample harvester according to described in claim 1 or 2 or 3 or 4 or 5, it is characterized in that: in the passage of described needle stand cover, be placed with solid-state anti-coagulants.
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| CN201610156259.4A CN105662439B (en) | 2016-03-18 | 2016-03-18 | It is exclusively used in mouse arterial blood sample acquisition device |
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| CN201610156259.4A CN105662439B (en) | 2016-03-18 | 2016-03-18 | It is exclusively used in mouse arterial blood sample acquisition device |
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| CN105662439B CN105662439B (en) | 2019-01-18 |
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| US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
| US11185677B2 (en) | 2017-06-07 | 2021-11-30 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
| US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
| US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
| US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
| US11964145B2 (en) | 2019-07-12 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
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| CN203107997U (en) * | 2013-01-23 | 2013-08-07 | 广州中医药大学第一附属医院 | Tee joint air passage joint |
| CN103315750A (en) * | 2013-07-02 | 2013-09-25 | 曹烽 | Arterial blood gas needle with medicine disposed in needle seat |
| CN103519830A (en) * | 2013-07-29 | 2014-01-22 | 吴洪磊 | Blood collection device used during invasive artery monitoring |
| CN204500730U (en) * | 2015-03-11 | 2015-07-29 | 张新玉 | Artery blood sampling equipment |
| CN204600497U (en) * | 2015-04-29 | 2015-09-02 | 南通大学附属医院 | A kind of arterial blood drawing pin |
| CN205041415U (en) * | 2015-10-14 | 2016-02-24 | 王宝琛 | Clinical laboratory is with quantitative vacuum blood sampling device |
| CN205514626U (en) * | 2016-03-18 | 2016-08-31 | 温州医科大学附属第一医院 | Mouse arterial blood appearance collection system is exclusively used in |
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