CN105662333A - Portable wide-angle eye bottom imaging device and method - Google Patents
Portable wide-angle eye bottom imaging device and method Download PDFInfo
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- 238000003384 imaging method Methods 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims abstract description 11
- 210000001525 retina Anatomy 0.000 claims abstract description 31
- 210000004087 cornea Anatomy 0.000 claims abstract description 20
- 238000012634 optical imaging Methods 0.000 claims abstract description 10
- 239000013307 optical fiber Substances 0.000 claims description 17
- 230000002207 retinal effect Effects 0.000 claims description 16
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- 210000000695 crystalline len Anatomy 0.000 description 80
- 230000004256 retinal image Effects 0.000 description 12
- 230000002028 premature Effects 0.000 description 10
- 238000005286 illumination Methods 0.000 description 8
- 208000017442 Retinal disease Diseases 0.000 description 6
- 206010038933 Retinopathy of prematurity Diseases 0.000 description 6
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- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 206010038923 Retinopathy Diseases 0.000 description 2
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- 208000005107 Premature Birth Diseases 0.000 description 1
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- 206010036590 Premature baby Diseases 0.000 description 1
- 206010036600 Premature labour Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/125—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes with contact lenses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/04—Babies, e.g. for SIDS detection
- A61B2503/045—Newborns, e.g. premature baby monitoring
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Abstract
The invention relates to a portable wide-angle eye bottom imaging device and method. The portable wide-angle eye bottom imaging device comprises an optical imaging system and a mobile terminal device. The optical imaging system comprises a light source assembly, a light-guide fiber set, a cornea contact lens, a field lens set, an image sensor, an image storage module and a wireless transmission module. The light source assembly is used for transmitting a medical cold light source, the light-guide fiber set connected with the light source assembly and provided with an annular light-emitting area is used for transmitting the light source to the cornea contact lens, the cornea contact lens guides the light source into a view field to illuminate the retina and transmits reflecting light of the retina to the field lens set, and the field lens set is used for changing the direction of emergent light of the cornea contact lens, carrying out focusing and projecting the emergent light to the image sensor for imaging. The image sensor is used for storing a generated image in the image storage module, and transmitting the image to the mobile terminal device through the wireless transmission module, and the retina image is checked through the mobile terminal device in real time. The portable wide-angle eye bottom imaging device is compact in structure, easy to operate and capable of obtaining high-contrast and high-definition wide-angle retina images in real time.
Description
Technical field
The present invention relates to a kind of medical imaging device and method, be specifically related to a kind of portable Radix Rumicis fundus imaging device and method checked suitable in premature infant or infant retinopathy.
Background technology
Retinopathy of prematurity is a kind of disease being likely to and causing premature infant or infant blinding, is the blind main cause of child. Retinopathy of prematurity is mainly in premature labor, and Birth Weight is light, has the neonate of oxygen uptake history, premature retinal disease cause blind child's ratio to be 8% in developed country after birth, and developing country is 40%, and some areas are even up to 60%.
Retinopathy of prematurity is divided into four-stage according to the order of severity, can cure at front three phases, vision can be caused major injury and be likely to blind by fourth stage, therefore diagnoses and treats, before pathological changes, the blind rate that can significantly reduce premature infant before premature retinal disease threshold pathological changes and severe threshold.
China causes rare 2～30,000 because of the child that retinopathy of prematurity is blind every year, and occurs VI case countless. " premature infant treats by oxygen and retinopathy guideline of prevention and treatment " within 2004, has been issued for this China's Ministry of Public Health, emphasize the premature infant of hospital's production, low birthweight infant, particularly there is the child of oxygen uptake history, all must carry out examination of ocular fundus, to find retinopathy of prematurity as early as possible, reduce blinding and the disability rate of premature infant and infant.
Conventional inspecting method to use in abundant platycoria situation, and observable visual field is little, is generally about 30 °. And retinopathy of prematurity occurs in retinal periphery region, can not coordinate plus premature infant, infant, check relatively difficult, it is necessary to use Radix Rumicis eye ground imaging device to optical fundus omnibearing imaging, diagnosis and the objective basis for the treatment of are provided for clinician.
Retina image-forming technology has been widely used for detection and the diagnosis of retinal diseases, but tradition fundus camera imaging viewing field is little, structure is complicated, there is no real-time display device, doctor can only to the imaging of patient retina elder generation, check again through special-purpose computer, complicated operation, be not also suitable for the inspection of premature retinal disease.
Summary of the invention
The technical problem to be solved is for the above-mentioned state of the art, it is provided that a kind of portable Radix Rumicis fundus imaging device and method.
This invention address that the technical scheme that above-mentioned technical problem adopts is:
A kind of portable Radix Rumicis fundus imaging device, including optical imaging system and mobile terminal device; Described optical imaging system includes light source assembly, optical fibers group, corneal contact lens, field lens group, imageing sensor, image storage module and wireless transport module; Described light source assembly is used for sending Medical Cold Light Source, light source is sent to corneal contact lens by the optical fibers group with annular luminous district being connected with light source assembly, and on corneal contact lens, form ring-shaped light spot, wherein, in described annular luminous district, the light source exit direction of arbitrfary point and the axis of corneal contact lens are certain angle of inclination; Described corneal contact lens contacts with cornea, for the concave surface optical lens that flexible material is made, wherein the one side near cornea is concave surface, one side away from cornea is convex surface, for guiding light source in visual field and receiving amphiblestroid reflection light, and reflection light is sent to field lens group, the mid portion of described ring-shaped light spot is form, the light source and the illuminating bundle that transmit pass through outside form, inside form, the light beam of retinal reflex and imaging beam pass through inside form, and described illuminating bundle separates with imaging beam; Described field lens group is arranged between corneal contact lens and imageing sensor, for changing the direction of corneal contact lens emergent light and being focused, projects and carries out imaging in described imageing sensor; The image of generation is stored in described image storage module by described imageing sensor, and sends described mobile terminal device to by described wireless transport module.
For optimizing technique scheme, the concrete measure taked also includes:
Described Medical Cold Light Source is infrared light and two kinds of light sources of visible ray, and wherein, infrared light is used for amphiblestroid observation and focusing, it is seen that light is used for amphiblestroid imaging.
The wavelength of described infrared light is 800nm, and the wavelength of described visible ray is 400 ~ 760nm.
The refractive index of described corneal contact lens is 1.8.
The surfaces externally and internally of described corneal contact lens scribbles optical anti-reflection coating.
Need not to foveal region of retina regional imaging time, the center of described corneal contact lens can arrange black region, to promote contrast and the definition of retinal periphery area image.
Described field lens group is rearranged by three field lenses, and first field lens is arranged on the focal length place of corneal contact lens, and second field lens is arranged on the focal length place of first field lens, and the 3rd field lens is arranged on the focal length place of second field lens.
In addition, also proposed a kind of method adopting above-mentioned portable Radix Rumicis fundus imaging device to carry out Radix Rumicis fundus imaging, comprise the following steps: step a: be set to light source assembly launch infrared light, regulate described angle of inclination, thus adjusting visual field size, infrared light is transferred to corneal contact lens by optical fibers group, and then is sent to retina, by mobile terminal device retina is observed and focuses; Step b: light source assembly is switched to transmitting visible ray, optical fibers group forms ring-shaped light spot on corneal contact lens, ring-shaped light spot mid portion is form, the light source and the illuminating bundle that transmit pass through outside form, inside form, the light beam of retinal reflex and imaging beam pass through inside form, and it is sent to field lens group through corneal contact lens, field lens group changes the direction from corneal contact lens emergent light and is focused, and projects and carries out retina image-forming in described imageing sensor.
Need not to foveal region of retina regional imaging time, the centrally disposed black region of corneal contact lens before step a and b, to promote contrast and the definition of retinal periphery area image.
The invention have the advantages that
1, imaging device system compact conformation, volume is little, and form diameter, at about 6mm, can realize the multi-angle wide-angle image of eye ground when not needing platycoria, and visual field can reach 140 degree;
2, light source transmits and adopts the through mode of optical fibers, farthest decreases light loss; Fibre-optic angle can adjust according to visual field size, maintaining uniform illumination, does not have dark space, local;
3, infrared and two kinds of light sources of visible ray are adopted, infrared light is used for amphiblestroid observation and focusing, visible ray is used for amphiblestroid imaging, human eye is not felt for infrared light, patient's myosis can also be avoided when long-time observation and focusing, imaging moment switches to visible ray, photographs the retinal image of high-contrast, definition under the exposure of several milliseconds of visible rays;
4, corneal contact lens is flexible material, it is possible to cornea good contact because the difference of the radius of curvature in form and form outer curvature radius can make illuminating ray focus on retina, and make illuminating bundle and imaging beam be kept completely separate;
5, illuminating ray and imaging light are kept completely separate, illuminating ray through corneal contact lens, cornea, crystalline lens Deng Yan soma refraction illuminate retina uniformly, imaging beam enters imageing sensor through the form of corneal contact lens, because illumination path and imaging optical path do not have common lens, add corneal contact lens and have ARC, the veiling glare produced because of reflextion from lens surface light can be avoided completely, it is ensured that the resolution of retinal images and contrast;
6, position and the focal length of imageing sensor can be regulated according to different human eye diopters and image space, to obtain eye ground image the most clearly;
7, under the effect of corneal contact lens and field lens group, position and the direction of retinal reflex light can be changed, imaging beam is focused, by all of light focusing a to plane, by the retinal images complanation picture of bending, by the clear record of imageing sensor;
8, need not to foveal region of retina regional imaging time, can by the central area painted black of corneal contact lens, so amphiblestroid central area because of do not have light to pass through to become black cannot imaging, but contrast and the definition of retinal periphery area image can be promoted further;
9, real time imaging output is combined with camera function, mobile terminal device Real Time Observation retinal images can be passed through, and retinal images is stored in image storage module.
Accompanying drawing explanation
Fig. 1 is the overall schematic of the present invention.
Fig. 2 is the structural representation of the optical imaging system of the present invention.
Fig. 3 is the front view of the optical imaging system of the present invention.
Fig. 4 is the imaging schematic diagram of the present invention.
Fig. 5 is the schematic diagram of corneal contact lens of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, embodiments of the invention are described in further detail.
Portable Radix Rumicis fundus imaging device as shown in Figure 1, including optical imaging system and mobile terminal device 9; Optical imaging system includes light source assembly 1, optical fibers group 2, corneal contact lens 4, field lens group 5, imageing sensor 6, image storage module 61 and wireless transport module 62.
Illustrate further combined with accompanying drawing 2-4, light source assembly 1 is used for sending Medical Cold Light Source, specifically can adopt infrared light and two kinds of light sources of visible ray, the wavelength of infrared light is 800nm, visible wavelength is 400 ~ 760nm, generally select the green-yellow light making wavelength that retinal images resolution is the highest at 560 ~ 580nm, its mid-infrared light is used for amphiblestroid observation and focusing, visible ray is used for amphiblestroid imaging, at imaging moment, infrared light is switched to visible ray, to avoid patient's myosis, under the exposure of several milliseconds of visible rays, photograph the retinal image of needs. The visible ray of different wave length is selected, to adapt to the high-quality imaging of retina different tissues also dependent on different retina image-forming positions.
Light source is sent to corneal contact lens 4 by the optical fibers group 2 with annular luminous district being connected with light source assembly 1, and on corneal contact lens 4, form ring-shaped light spot 7, wherein, in annular luminous district, the light source exit direction of arbitrfary point and the axis of corneal contact lens 4 are certain angle of inclination. Compared to the axis parallel outgoing with corneal contact lens 4, adopt certain angle of inclinationThe outgoing carrying out light source can effectively increase visual field, it is achieved wide-angle image, and can according to actual visual field demand to angle of inclinationIt is adjusted. Wherein, optical fibers group 2 can be selected for glass optical fiber, adopting total reflection form to carry out light source and transmits to realize effective ring illumination, thus realizing better illuminance, reducing light loss.
Corneal contact lens 4 contacts with cornea, for guiding light source in visual field and receiving amphiblestroid reflection light, and reflection light is sent to field lens group 5. the mid portion of ring-shaped light spot 7 is form 8, the light source transmitted and illuminating bundle pass through from form 8 is outside, internal without form 8, the light beam of retinal reflex and imaging beam pass through from form 8 is internal, because cornea and lenticular front surface can produce reflection light, resolution and the definition of retinal images is affected in order to stop these reflection light to arrive imageing sensor, illumination light must be separated with imaging, need at corneal contact lens, cornea and crystalline lens front surface leave different regions for illumination and imaging, namely form 8 is outer is illumination, it is imaging region in form 8, in order to obtain Radix Rumicis retina image-forming, also need to window dimension is any limitation as. refraction by corneal contact lens 4, cornea and crystalline lens front and rear surfaces, it may be achieved the retinal illumination of 140 ° of visual fields and imaging, the now diameter of form 8 about 6mm.
Corneal contact lens 4 is flexible material, can carry out good contacting with cornea, and for concave surface optical lens, wherein the one side near cornea is concave surface, and the one side away from cornea is convex surface, and refractive index is chosen as 1.8, and focal length is just. Such setting can avoid the light from retinal periphery to produce total internal reflection in cornea-Air Interface because reflecting in a large number, and rim ray can be focused on, reduce the solid angle containing subretinal space real image, so that the retinal images of whole visual field is by imageing sensor 6 imaging.
Corneal contact lens 4 also has the radius of curvature close with corneal curvature radius, wherein the extra-regional radius of curvature of form 8 is less than the radius of curvature in form 8 region, peripheral in form 8 region forms an annular projection, protruding position can be set to about 3mm to the distance at center, thus allowing the illuminating bundle entered in eyes focus on the retina, rather than focus on retina front of or behind, retina is clearly illuminated and imaging.
Although the light source shooting angle of optical fibers group 2Imageing sensor 6 cannot be directly entered with corneal contact lens 4 by the reflection light being carefully designed so that cornea and crystalline lens front surface, but still very strong veiling glare can be caused, thus reducing retinal image quality. In order to ensure the quality of retinal images, optical anti-reflection coating one layer harder can be scribbled on the surfaces externally and internally of corneal contact lens 4, to reduce the impact of mixed and disorderly light.
Need not to foveal region of retina regional imaging time, can also by the central area painted black of corneal contact lens 4, so amphiblestroid central area because of do not have light to pass through to become black cannot imaging, but contrast and the definition of image around foveal region of retina region can be promoted further.
Coaxial-illuminating or non-coaxial illumination can be selected as required when being illuminated, what adopt in the embodiment shown in Fig. 1-2 is coaxial-illuminating, namely the annular luminous district of optical fibers group 2 is coaxial with corneal contact lens 4, annular luminous district forms ring-shaped light spot 7 on corneal contact lens 4, the mid portion of ring-shaped light spot 7 is form 8, now, corneal contact lens 4, ring-shaped light spot 7 and form 8 are coaxial.
As it is shown in figure 5, field lens group 5 is arranged between corneal contact lens 4 and imageing sensor 6, for changing the direction of corneal contact lens 4 emergent light and being focused, projects and imageing sensor 6 carries out imaging. In embodiment, field lens group 5 is rearranged by three field lenses, be equivalent to a triplet group, first field lens is arranged on the focal length place of corneal contact lens 4, and second field lens is arranged on the focal length place of first field lens, and the 3rd field lens is arranged on the focal length place of second field lens.
Image is after imageing sensor 6 is flutterred and caught, it is sent on mobile terminal device 9 by wireless transport module 62, it is shown in real time on the screen of mobile terminal device 9, and retinal images is stored on image storage module 61, can read and copy image after being connected with computer. Imageing sensor 6 can also side-to-side movement vertically, to adapt to different dioptric human eye, it is thus achieved that eye ground image the most clearly. Wherein, wireless transport module 62 can adopt wifi transport module, and mobile terminal device 9 can adopt Android device.
When using this portable Radix Rumicis fundus imaging device to carry out imaging, first it is set to light source assembly 1 launch infrared light, regulates angle of inclination, thus adjusting visual field size, infrared light is transferred to corneal contact lens 4 by optical fibers group 2, and then is sent to retina, utilizes imageing sensor 6 retina is observed and focuses; Then light source assembly 1 is switched to transmitting visible ray, optical fibers group 2 forms ring-shaped light spot 7 on corneal contact lens 4, ring-shaped light spot 7 mid portion is form 8, the light source transmitted and illuminating bundle pass through from form 8 is outside, internal without form 8, the light beam of retinal reflex and imaging beam pass through from form 8 is internal, and it is sent to field lens group 5 through corneal contact lens 4, field lens group 5 changes the direction from corneal contact lens 4 emergent light and is focused, and projects and carries out retina image-forming in imageing sensor 6.
Need not to foveal region of retina regional imaging time, the centrally disposed black region of corneal contact lens 4 before above step, to promote contrast and the definition of retinal periphery area image.
Below being only the preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-described embodiment, and all technical schemes belonged under thinking of the present invention belong to protection scope of the present invention. It should be pointed out that, for those skilled in the art, some improvements and modifications without departing from the principles of the present invention, should be regarded as protection scope of the present invention.
Claims (9)
1. a portable Radix Rumicis fundus imaging device, it is characterised in that include optical imaging system and mobile terminal device (9), described optical imaging system includes light source assembly (1), optical fibers group (2), corneal contact lens (4), field lens group (5), imageing sensor (6), image storage module (61) and wireless transport module (62), described light source assembly (1) is used for sending Medical Cold Light Source, light source is sent to corneal contact lens (4) by the optical fibers group (2) with annular luminous district being connected with light source assembly (1), and on corneal contact lens (4), form ring-shaped light spot (7), wherein, in described annular luminous district, the light source exit direction of arbitrfary point and the axis of corneal contact lens (4) are certain angle of inclination, described corneal contact lens (4) contacts with cornea, for the concave surface optical lens that flexible material is made, wherein the one side near cornea is concave surface, one side away from cornea is convex surface, for guiding light source in visual field and receiving amphiblestroid reflection light, and reflection light is sent to field lens group (5), the mid portion of described ring-shaped light spot (7) is form (8), the light source transmitted and illuminating bundle pass through from form (8) is outside, internal without form (8), the light beam of retinal reflex and imaging beam pass through from form (8) is internal, described illuminating bundle separates with imaging beam, described field lens group (5) is arranged between corneal contact lens (4) and imageing sensor (6), is used for changing the direction of corneal contact lens (4) emergent light and being focused, projects in described imageing sensor (6) and carry out imaging, the image of generation is stored in described image storage module (61) by described imageing sensor (6), and sends described mobile terminal device (9) to by described wireless transport module (62).
2. the portable Radix Rumicis fundus imaging device of one according to claim 1, it is characterised in that: described Medical Cold Light Source is infrared light and two kinds of light sources of visible ray, and wherein, infrared light is used for amphiblestroid observation and focusing, it is seen that light is used for amphiblestroid imaging.
3. the portable Radix Rumicis fundus imaging device of one according to claim 2, it is characterised in that: the wavelength of described infrared light is 800nm, and the wavelength of described visible ray is 400 ~ 760nm.
4. the portable Radix Rumicis fundus imaging device of one according to claim 1, it is characterised in that: the refractive index of described corneal contact lens (4) is 1.8.
5. the portable Radix Rumicis fundus imaging device of one according to claim 1, it is characterised in that: the surfaces externally and internally of described corneal contact lens (4) scribbles optical anti-reflection coating.
6. the portable Radix Rumicis fundus imaging device of one according to claim 1, it is characterized in that: need not to foveal region of retina regional imaging time, the center of described corneal contact lens (4) can arrange black region, to promote contrast and the definition of retinal periphery area image.
7. the portable Radix Rumicis fundus imaging device of one according to claim 1, it is characterized in that: described field lens group (5) is rearranged by three field lenses, first field lens is arranged on the focal length place of corneal contact lens (4), second field lens is arranged on the focal length place of first field lens, and the 3rd field lens is arranged on the focal length place of second field lens.
8. one kind adopts the method that the portable Radix Rumicis fundus imaging device as according to any one of claim 1-7 carries out Radix Rumicis fundus imaging, it is characterised in that comprise the following steps:
Step a: be set to light source assembly (1) launch infrared light, regulate described angle of inclination, thus adjusting visual field size, infrared light is transferred to corneal contact lens (4) by optical fibers group (2), and then it is sent to retina, by mobile terminal device (9) retina observed and focus;
Step b: light source assembly (1) is switched to transmitting visible ray, optical fibers group (2) forms ring-shaped light spot (7) on corneal contact lens (4), ring-shaped light spot (7) mid portion is form (8), the light source transmitted and illuminating bundle pass through from form (8) is outside, internal without form (8), the light beam of retinal reflex and imaging beam pass through from form (8) is internal, and it is sent to field lens group (5) through corneal contact lens (4), field lens group (5) changes the direction from corneal contact lens (4) emergent light and is focused, project in described imageing sensor (6) and carry out retina image-forming.
9. the method for a kind of Radix Rumicis fundus imaging according to claim 8, it is characterized in that: need not to foveal region of retina regional imaging time, the centrally disposed black region of corneal contact lens (4) before step a and b, to promote contrast and the definition of retinal periphery area image.
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| CN113662507A (en) * | 2020-05-14 | 2021-11-19 | 株式会社 Msc Lab | Cornea contact type ophthalmology digital microscope |
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