CN105651728B - A kind of portable near infrared spectrum detection system - Google Patents
A kind of portable near infrared spectrum detection system Download PDFInfo
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- CN105651728B CN105651728B CN201610023455.4A CN201610023455A CN105651728B CN 105651728 B CN105651728 B CN 105651728B CN 201610023455 A CN201610023455 A CN 201610023455A CN 105651728 B CN105651728 B CN 105651728B
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- 238000001514 detection method Methods 0.000 title claims abstract description 132
- 238000002329 infrared spectrum Methods 0.000 title claims abstract description 58
- 238000004566 IR spectroscopy Methods 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 36
- 238000004611 spectroscopical analysis Methods 0.000 claims description 28
- 238000001228 spectrum Methods 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 20
- 230000003287 optical effect Effects 0.000 claims description 10
- 230000003595 spectral effect Effects 0.000 claims description 10
- 229910052738 indium Inorganic materials 0.000 claims description 8
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims description 8
- 238000004458 analytical method Methods 0.000 claims description 7
- 229910052721 tungsten Inorganic materials 0.000 claims description 6
- 239000010937 tungsten Substances 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 5
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 5
- 238000013508 migration Methods 0.000 abstract description 2
- 230000005012 migration Effects 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 100
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
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- 238000005516 engineering process Methods 0.000 description 6
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 description 4
- 125000003636 chemical group Chemical group 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
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- 238000004519 manufacturing process Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000004451 qualitative analysis Methods 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000013307 optical fiber Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 description 2
- 229960004005 amlodipine besylate Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000009659 non-destructive testing Methods 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 238000010183 spectrum analysis Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- -1 tungsten halogen Chemical class 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 101100346764 Mus musculus Mtln gene Proteins 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N N-acetyl-para-amino-phenol Natural products CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
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- 229960004099 azithromycin Drugs 0.000 description 1
- VQLYBLABXAHUDN-UHFFFAOYSA-N bis(4-fluorophenyl)-methyl-(1,2,4-triazol-1-ylmethyl)silane;methyl n-(1h-benzimidazol-2-yl)carbamate Chemical compound C1=CC=C2NC(NC(=O)OC)=NC2=C1.C=1C=C(F)C=CC=1[Si](C=1C=CC(F)=CC=1)(C)CN1C=NC=N1 VQLYBLABXAHUDN-UHFFFAOYSA-N 0.000 description 1
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- 239000007919 dispersible tablet Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
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- 239000011159 matrix material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
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- 238000012706 support-vector machine Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
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- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The present invention relates to infrared spectroscopy detection technique fields, more particularly to a kind of portable near infrared spectrum detection system, including shell, it is sequentially arranged at the intracorporal acquisition window of shell, detection light source, light-dividing device and detector from the bottom to top, converter and power supply unit are also equipped in the shell, the output end of detector is connect with the input terminal of the converter, and power supply unit is connect with detection light source, detector and converter respectively；It further include sample cell, sample cell is mounted on the acquisition window, and the sample cell, which is divided into, sets sample portion and fixed part, and described set is provided with lattice block in sample portion, and the lattice block is provided centrally with through-hole, and the fixed part is fixedly mounted on acquisition window；The light-dividing device is linear variable filter.A kind of portable near infrared spectrum detection system of the invention greatly improves detection accuracy in the case where not expanding equipment volume and weight, solves the problems, such as that model migration is difficult.
Description
Technical field
The present invention relates to infrared spectroscopy detection technique fields, and in particular to a kind of portable near infrared spectrum detection system.
Background technique
Near-infrared spectral analysis technology (Near Infrared, NIR) be between visible light (Vis) and in infrared (MIR) it
Between electromagnetic radiation as waves, U.S. material detection association (ASTM) near infrared spectrum is defined as the region of 780-2526nm, be
First non-visible light area that the mankind have found in absorption spectrum.Hydric group near infrared spectrum and organic molecule (OH,
NH, CH) vibration sum of fundamental frequencies it is consistent with the uptake zone of frequencys multiplication at different levels, pass through scanning sample near infrared spectrum, available sample
The characteristic information of middle organic molecule hydric group, and using near-infrared spectrum technique analysis sample have easily and fast, it is high
The advantages that effect, accurate and cost is relatively low, does not destroy sample, does not consume chemical reagent, free from environmental pollution, therefore the technology is by more
Carry out the favor of more people.
Due to technical level limitation and examination criteria it is stringent, to guarantee to detect quality, common near-infrared both at home and abroad
Detection device is larger by the time of Fourier Transform Technique and Influence of Displacement.The beam splitting system of near-infrared needs larger sky simultaneously
Between, therefore the volume and weight of equipment and product can not become smaller, presentation volume is big mostly, weight is big, at high cost, application scenarios limitation
The disadvantages of.
With the continuous development of science and technology, it is detected for the real-time live of drug.Occur successively both at home and abroad portable
Near infrared detection equipment.Equipment by: acquisition window, light source, beam splitting system, detector, operation sequence and power supply system form.Its
In: acquisition window uses CCD, behaviour using grating or integrating sphere, detector using tungsten halogen lamp, beam splitting system using optical fiber, light source
Make system using flush type LINUX, power supply system using such as lithium battery or mobile power source.For the angle of application client,
Near infrared detection equipment solves the problems, such as to be to carry out the qualitative and quantitative non-destructive testing of sample in the case where not destroying sample.
Such as drug, the purpose of qualitative non-destructive testing are to know the place of production of this sample and brand, play tracing and sample is true and false
Effect.The purpose of quantitative NDT is to know the various elements content of this sample, but in the prior art is directed to drug
There are still following problems for the Portable near infrared detection device of sample detection: 1, drug sample has particularity, such as sheet, capsule
Shape etc. does not collect representative sample message in spectra collection since fibre-optical probe contact surface is smaller；2, it is directed to
Qualitative analysis and detection, same type equipment precision is lower both at home and abroad at present, causes testing result and actual result error larger；3,
Portable near infrared detection device testing result in the prior art is still unstable, causes result without availability；4, due to close red
Outer detection device must calibrated before, and the principle of calibration is different attribute and precision according to equipment, to Natural light intensity
It is acquired, and acquires maximum absorbance with calibration module, to determine the time of integration, but existing Portable near infrared detection device
Due to the factor of natural light, causes the uncertain factor of calibration reliable more, can not accurately obtain testing result.
It can be seen that can aiming at the shortcomings in the prior art, provide a kind of higher precision, cheap, small volume,
Lighter in weight, continuous working period are longer, the stronger novel Portable near infrared detection based on drug sample of user experience
Equipment becomes those skilled in the art's technical problem urgently to be resolved.
Summary of the invention
In order to solve the above-mentioned technical problem the present invention, provides a kind of portable near infrared spectrum detection system, can be effective
The infrared spectroscopy detection for realizing drug sample, carries out qualitative and quantitative analysis, easy to operate, and quickly, measurement result is accurate for measurement
Reliably.
In order to reach above-mentioned technical effect, the present invention includes following technical scheme:
A kind of portable near infrared spectrum detection system including shell, the acquisition window being arranged on shell, is successively installed
Detection light source, light-dividing device and the detector being located along the same line in shell and with the acquisition window, in the shell
It is also equipped with converter and power supply unit, the output end of the detector is connect with the input terminal of the converter, the power supply
Device is connect with detection light source, detector and converter respectively；It further include sample cell, the sample cell is mounted on the collecting window
On mouth, the sample cell, which is divided into, sets sample portion and fixed part, and described set is provided with lattice block in sample portion, the center of the lattice block is set
It is equipped with through-hole, the fixed part is fixedly mounted on acquisition window；The light-dividing device is linear variable filter.
The sample that the detection light source irradiates in the sampling member obtains optical signal through diffusing reflection, and the optical signal enters line
Property gradual filter through dispersion obtain light beam, the detector receives that the light beam is converted to obtain electric signal, and by the electricity
Signal is exported to converter, and the converter exports after the received electric signal is converted to spectroscopic data.
It is test sample since lattice block upper end is devices, the lower ends such as light source, light-dividing device and detector.From near-infrared skill
For in the principle of art, since equipment belongs to highly sophisticated device, to guarantee detection accuracy and quality, therefore when detecting in order to guarantee
Sample is not directly contacted with intermodule, uses lattice block and sample is isolated with module.The design of through-hole, it is ensured that sample can
It is put into through-hole, drug shape is generally divided into capsule shape, diamond shaped, round etc., and it is logical to devise this according to the size of drug
Pore size, when monitoring drug sample, drug sample can be placed in sample portion through hole limit, prevent drug sample roll or
The problem shaken and cause prohibited data detection true.Optical fiber type (diameter 5mm) acquisition window in the prior art, due to window compared with
Small, the spectral information caused is local message, not up to the standardisation requirements of sample acquisition, relatively due to solid sample
Firmly, rough surface.OH, NH, CH chemical group information content are impacted in the spectrum that spectral information limitation causes in acquisition,
Cause the spectrum of acquisition without representativeness.Simultaneously in the prior art using grating or integrating sphere as beam splitting system, is sampling and examining
During survey light source sample body surface face and by OH, NH, CH chemical group information by diffusing reflection or transmission by way of return
To during beam splitting system, since grating or integrating sphere principle limit, if being near or below the object of wavelength by a size
Stop, just bypasses this object, continue.If be bordering on by a size or less than wavelength hole, centered on hole, shape
It is propagated before circularizing wave direction.Cause in sampling process be biased to angle it is about small, wavelength is longer, and spectra overlapping, to cause to do
It disturbs larger.
Sample cell of the present invention is the structure of autonomous Design, reasonable in design, Neng Gouyu for drug sample characteristic
Larger acquisition window matching uses, and solves using weak output signal when optical fiber, needs integrating sphere will multiple irreflexive optical information
Carry out cumulative problem.Using linear variable filter, solve the influence that spectrum segment is corresponded to there are spectra overlapping due to spectrum,
Cause the problem that precision is lower.
Further, the sample cell is made of aluminum alloy materials, and fixed part is screwed on the acquisition window.
Further, the diameter of the through-hole is 30~40mm, a height of 5mm, is connected with lid on the shell, institute
Lid is stated to be located at outside the sample cell.
Preferably, the diameter of the through-hole is 35mm.
When needing to detect, lid can be changed on shell, dark situation, i.e. darkroom can be formed, and then fully absorbed to be measured
The chemical information of sample and the spectroscopic data that makes is more high-quality accurate.
Further, the detector is 128 line element non-brake method indium Ga-As diode array detectors, and the converter is
A/D converter.
Using 128 line element non-brake method indium gallium arsenic (inGaAs) diode arrays, will not occur due to accumulative look after,
Cause detector temperature excessively high to cause the lower influence of precision.And spectral signal-noise ratio influence is reduced, what is made is original
Spectrum is more stable, efficient.
Further, the light source is double integrated vacuum tungsten lamps.It is small that double integrated vacuum tungsten light source service life are greater than 1.7 ten thousand
When, solve the problems, such as light source service life.
Further, the power supply unit is rechargeable battery, is equipped with charging plug on the shell.It is described to fill an electricity
Pond is lithium battery, continuous standby and operating time 8 hours solve the problems, such as that traditional product stand-by time is short.
Further, power switch is installed, the power switch is connect with the power supply unit on the shell.
Further, the spectral region of the linear variable filter is 900~1700nm.
Traditional equipment wave band is 700nm~1100nm, and spectral coverage is limited, the chemical group of the spectral information reaction of sample occurs
Limited or even useless problem, the problem of causing model foundation error larger or can not model.Integrated, this patent by software and hardware
900~1700nm of wave-length coverage, increases wave band, improves the chemical group of spectral information reaction.So that model is more accurate.
Further, the portable near infrared spectrum detection system further include micro-central controller, with it is described miniature
The client of central controller wireless communication connection, the micro-central controller are mounted in shell, the miniature center control
Device processed and the power supply unit, detection light source, detector and converter are connect, and the micro-central controller is by the converter
Spectroscopic data after conversion is transmitted to client, and the control signal for receiving the client transmissions control the detection light source,
The opening and closing of detector and converter.
Further, the client includes that the calibration module, detection module and data successively chosen in order show mould
Block；
Client is set to send a control signal to micro-central controller, the miniature center control by choosing calibration module
The calibration spectrum data of device receiving converter output, and the calibration spectrum data are exported to client, the data are shown
Module is for showing calibration spectrum data；
Client is set to send a control signal to micro-central controller, the miniature center control by choosing detection module
The detection spectroscopic data of device receiving converter output, and the detection spectroscopic data is exported to client, the data are shown
Module is for showing detection spectroscopic data.
Further, the portable near infrared spectrum detection system further includes cloud database, the cloud database
It is communicated to connect with the client wireless, the chemometric model of sample to be tested, institute is stored in the cloud database
It states detection module to export the detection spectroscopic data to cloud database, the detection that the cloud database will receive
The chemometric model of spectroscopic data and sample to be tested compares analysis and obtains the qualitative data and quantitative data of sample to be tested,
And the qualitative data and quantitative data are sent to data disaply moudle, the data disaply moudle is for showing qualitative data
And quantitative data.
Further, the qualitative data includes nomenclature of drug, type and the place of production, and quantitative data includes drug effective component
And the content value of adjunct ingredient.
Chemometric model is placed on cloud, realizes Internet of Things theory, so that detection accuracy is higher, better effect makes
With more preferably convenient.Since near-infrared examines the limitation and principle factor of technology fastly, the technical parameter of every equipment room is caused to have one
Determine error, such as acquire spectroscopic data with A equipment and establish model, will appear certain error when B device is using the model, make
At testing result inaccuracy, to solve this problem, this patent is asked using the error that the algorithm of independent research solves equipment room
Topic realizes that a model multiple devices use the technical problem of 0 error.
Chemical Measurement has become the indispensable important component in near-infrared spectrum analysis.Principal component analysis
(PCA) and offset minimum binary (pLS) is classical chemometrics method, and the most common side in near-infrared spectrum analysis
Method.PCA is that all common method, main purpose are Data Dimensionality Reductions in near-infrared qualitative and quantitative analysis, close red to eliminate
Overlapped part in external spectrum information is that spectroscopic data is obtained and reflected to the limit to covariance maximum direction projection
The new variables of the Nomenclature Composition and Structure of Complexes information of sample, but since projection process is uncorrelated to dependent variable, general forecast precision is not
It is very high.Model is established with PLS, the information that can use whole spectrum analyzes sample, by the decomposition of spectrum matrix and returns
Return interactive progress, non-linear due to spectrum will lead to over-fitting, and the application of near infrared spectrum is restricted sometimes.
Support vector machines, which is used near infrared spectrum, can effectively improve over-fitting, and it allows high dimensional data to make
For input vector, spectrum nonlinear change problem caused by the variables such as temperature can be well solved.Therefore, for each change
For learning metrology method, there are respective merits and demerits, may be somewhat prohibitive near infrared light time spectrum.At present
These methods be combined with each other by existing research person, learn from other's strong points to offset one's weaknesses, then are applied in near-infrared spectral analysis technology.
Further, the client is one of computer, tablet computer and mobile phone.
The operating system of client uses ios and Android APP program, PC, LINUX program phase with traditional product
Than, customer experience sense is more preferable, and UI is exquisite, and it is easy to operate, flexible, it is easy to operate.Solve the problems, such as that outdoor study is inconvenient for use.
A kind of purposes of portable near infrared spectrum detection system, the portable near infrared spectrum detection system is above-mentioned
Portable near infrared spectrum detection system, the portable near infrared spectrum detection system is for detecting drug sample, institute
It states drug sample and is added to and set in sample portion.
A kind of powder sample near infrared spectrum detection method is carried out using above-mentioned portable near infrared spectrum detection system
Detection, described detection method includes the following steps:
Step 1: the foundation of powder sample chemometric model；
Step 2: the detection of powder sample: the sample is placed in sampling member, successively chooses calibrating die by client
Block and detection module, the spectroscopic data that the client will test are exported to cloud database, are counted with the chemistry of sample to be tested
Amount learns model comparison analysis and obtains the qualitative data and quantitative data of sample to be tested, and the qualitative data and quantitative data are sent to
Data disaply moudle.
By adopting the above technical scheme, including following the utility model has the advantages that a kind of portable near infrared spectrum detection system of the invention
System, in the case where not expanding equipment volume and weight, greatly improves detection accuracy, solves the problems, such as that model migration is difficult.
Drug sample can be effectively reacted simultaneously to the qualitative analysis and the quantitative data of infrared light as a result, detection process is only 5
It can be completed in second.Quickly, the operation for conveniently, avoiding cumbersome time-consuming, saves a large amount of time and manpower.It is suitable for large-scale popularization
With use.Present system Detection wavelength range is 900~1700nm simultaneously, and global shape is to erect rectangle, having a size of 150
× 70 × 58mm, weight are less than 500g, and standby time reaches 8 hours, use convenient for field operation detection, compact and flexible, are convenient for
It carries.
Detailed description of the invention
Fig. 1 is sample pool structure schematic diagram of the present invention；
Fig. 2 is the portable near infrared spectrum detection system schematic cross-section of the embodiment of the present invention one；
Fig. 3 is the portable near infrared spectrum detection system structure of the embodiment of the present invention two；
Fig. 4 is the portable near infrared spectrum detection system structure of the embodiment of the present invention three；
Fig. 5 is the modelling effect figure of amlodipine besylate tablets sample of the present invention.
In figure,
1, shell；11, lid；2, acquisition window；21, sample cell；211, sample portion is set；212, fixed part；213, lattice block；
2131, through-hole；3, light source is detected；4, light-dividing device；5, detector；6, converter；7, power supply unit；71, power switch；8, micro-
Type central controller；9, client；91, calibration module；92, detection module；93, data disaply moudle；10, cloud database.
Specific embodiment
The present invention is described in further detail below by specific embodiment and in conjunction with attached drawing.
Embodiment one: as depicted in figs. 1 and 2, a kind of portable near infrared spectrum detection system, including shell 1, setting exist
Acquisition window 2 on shell, be sequentially arranged at the detection light source 3 being located along the same line in shell and with the acquisition window,
Light-dividing device 4 and detector 5, are also equipped with converter 6 and power supply unit 7 in the shell, the output end of the detector with
The input terminal of the converter connects, and the power supply unit is connect with detection light source, detector and converter respectively；It further include sample
Product pond 21, the sample cell are mounted on the acquisition window, and the sample cell is divided into the sample portion 211 and fixed part 212 of setting, described
It sets and is provided with lattice block 213 in sample portion, the lattice block is provided centrally with through-hole 2131, and the fixed part, which is fixedly mounted on, to be adopted
Collect on window；The light-dividing device is linear variable filter.
A kind of purposes of portable near infrared spectrum detection system, the portable near infrared spectrum detection system is above-mentioned
Portable near infrared spectrum detection system, the portable near infrared spectrum detection system is for detecting drug sample, institute
It states drug sample and is added to and set in sample portion.
Embodiment two: as shown in figures 1 and 3, a kind of portable near infrared spectrum detection system, including shell 1, setting exist
Acquisition window 2 on shell, be sequentially arranged at the detection light source 3 being located along the same line in shell and with the acquisition window,
Light-dividing device 4 and detector 5, are also equipped with converter 6 and power supply unit 7 in the shell, the output end of the detector with
The input terminal of the converter connects, and the power supply unit is connect with detection light source, detector and converter respectively；It further include sample
Product pond 21, the sample cell are mounted on the acquisition window, and the sample cell is divided into the sample portion 211 and fixed part 212 of setting, described
It sets and is provided with lattice block 213 in sample portion, the lattice block is provided centrally with through-hole 2131, and the fixed part, which is fixedly mounted on, to be adopted
Collect on window；The light-dividing device is linear variable filter.
The diameter of the through-hole is 30~40mm, a height of 5mm, specifically, the diameter of the through-hole can for 30mm, 32mm,
35mm, 37mm and 40mm.Preferably, the diameter of the through-hole is 35mm.Lid 11, the lid are connected on the shell
Body is located at outside the sample cell.
The detector is 128 line element non-brake method indium Ga-As diode array detectors, and the converter is A/D conversion
Device.
The light source is double integrated vacuum tungsten lamps.
The power supply unit is rechargeable battery, is equipped with charging plug on the shell.
Power switch 71 is installed, the power switch is connect with the power supply unit on the shell.
The spectral region of the linear variable filter is 900~1700nm.
The portable near infrared spectrum detection system further includes that micro-central controller 8 and the miniature center control
The client 9 of device wireless communication connection, the micro-central controller are mounted in shell, the micro-central controller and institute
It states power supply unit, detection light source, detector to connect with converter, after the micro-central controller converts the converter
Spectroscopic data is transmitted to client, and the control signal for receiving the client transmissions control the detection light source, detector and
The opening and closing of converter.
The client includes the calibration module 91, detection module 92 and data disaply moudle 93 successively chosen in order；
Client is set to send a control signal to micro-central controller, the miniature center control by choosing calibration module
The calibration spectrum data of device receiving converter output, and the calibration spectrum data are exported to client, the data are shown
Module is for showing calibration spectrum data；
Client is set to send a control signal to micro-central controller, the miniature center control by choosing detection module
The detection spectroscopic data of device receiving converter output, and the detection spectroscopic data is exported to client, the data are shown
Module is for showing detection spectroscopic data.
A kind of purposes of portable near infrared spectrum detection system, the portable near infrared spectrum detection system is above-mentioned
Portable near infrared spectrum detection system, the portable near infrared spectrum detection system is for detecting drug sample, institute
It states drug sample and is added to and set in sample portion.
Embodiment three: as shown in Figure 1 and Figure 4, a kind of portable near infrared spectrum detection system, including shell 1, setting exist
Acquisition window 2 on shell, be sequentially arranged at the detection light source 3 being located along the same line in shell and with the acquisition window,
Light-dividing device 4 and detector 5, are also equipped with converter 6 and power supply unit 7 in the shell, the output end of the detector with
The input terminal of the converter connects, and the power supply unit is connect with detection light source, detector and converter respectively；It further include sample
Product pond 21, the sample cell are mounted on the acquisition window, and the sample cell is divided into the sample portion 211 and fixed part 212 of setting, described
It sets and is provided with lattice block 213 in sample portion, the lattice block is provided centrally with through-hole 2131, and the fixed part, which is fixedly mounted on, to be adopted
Collect on window；The light-dividing device is linear variable filter.
The diameter of the through-hole is 30~40mm, a height of 5mm, specifically, the diameter of the through-hole can for 30mm, 32mm,
35mm, 37mm and 40mm.Preferably, the diameter of the through-hole is 35mm.Lid 11, the lid are connected on the shell
Body is located at outside the sample cell.
The detector is 128 line element non-brake method indium Ga-As diode array detectors, and the converter is A/D conversion
Device.
The light source is double integrated vacuum tungsten lamps.
The power supply unit is rechargeable battery, is equipped with charging plug on the shell.
Power switch 71 is installed, the power switch is connect with the power supply unit on the shell.
The spectral region of the linear variable filter is 900~1700nm.
The portable near infrared spectrum detection system further includes that micro-central controller 8 and the miniature center control
The client 9 of device wireless communication connection, the micro-central controller are mounted in shell, the micro-central controller and institute
It states power supply unit, detection light source, detector to connect with converter, after the micro-central controller converts the converter
Spectroscopic data is transmitted to client, and the control signal for receiving the client transmissions control the detection light source, detector and
The opening and closing of converter.
The client includes the calibration module 91, detection module 92 and data disaply moudle 93 successively chosen in order；
Client is set to send a control signal to micro-central controller, the miniature center control by choosing calibration module
The calibration spectrum data of device receiving converter output, and the calibration spectrum data are exported to client, the data are shown
Module is for showing calibration spectrum data；
Client is set to send a control signal to micro-central controller, the miniature center control by choosing detection module
The detection spectroscopic data of device receiving converter output, and the detection spectroscopic data is exported to client, the data are shown
Module is for showing detection spectroscopic data.
The portable near infrared spectrum detection system further includes cloud database 10, the cloud database and the visitor
Family end wireless communication connects, and the chemometric model of sample to be tested, the detection mould are stored in the cloud database
Block exports the detection spectroscopic data to cloud database, the detection spectroscopic data that the cloud database will receive
Analysis is compared with the chemometric model of sample to be tested and obtains the qualitative data and quantitative data of sample to be tested, and will be described
Qualitative data and quantitative data are sent to data disaply moudle, and the data disaply moudle is for showing qualitative data and quantitative number
According to.
The qualitative data includes nomenclature of drug, type and the place of production, quantitative data include drug effective component and auxiliary material at
The content value divided.
A kind of purposes of portable near infrared spectrum detection system, the portable near infrared spectrum detection system is above-mentioned
Portable near infrared spectrum detection system, the portable near infrared spectrum detection system is for detecting drug sample, institute
It states drug sample and is added to and set in sample portion.
The detection method of the portable near infrared spectrum detection system of the present invention, comprising the following steps:
1, it establishes the chemometric model of sample to be tested: carrying out the autonomous of algorithm and model with MATHLAB software
Research and development and programming, meet enterprise and professional standard, optional preprocessing procedures and a variety of deterministic algorithms.Based on drug sample,
Modelling effect is as shown in Figure 5.For amlodipine besylate tablets, compound acetaminophen alkyl amine, Azithromycin dispersible tablet and A Moxi
The same brand different batches of woods and the like products of different brands have carried out model foundation, and model accuracy has reached 97.5%.
2, starting hardware power switch, is started by micro-central controller program and equipment power supply starts running, together
When open client APP program, pass through WIFI traffic model carry out equipment wireless connection.
3, the sample cell placement based on drug sample of independent research is mounted on the acquisition window.The choosing of APP client
The drug sample for needing to detect is selected, " drug detection " APP is clicked by order and is sent to cloud database, while cloud database is called
Drug chemistry meterological model.
4, since near infrared technology need to determine light intensity and the time of integration, therefore APP client clicks calibration.Equipment light source opens
It is dynamic, calibration block is put into sample cell, light source emits stable near infrared light signal and reaches calibration block and diffusing reflection, light occurs
Signal enters in linear variable filter.Dispersion occurs for optical signal in linear variable filter, and polychromatic light diverges to monochromatic light,
Light beam after dispersion enters detector 128 line element non-brake method indium gallium arsenic (inGaAs) diode array, is converted by 16 A/D
Photoelectric conversion is obtained electric signal and generates image in a detector by device, obtains maximum absorbance.And under APP client occurs
The prompt of one step.
5, calibration block is taken down, APP function button is clicked, light source is closed at this time, and is acquired to Natural light intensity, near-infrared
Optical signal collects Natural light intensity, and optical signal enters in beam splitting system (linear variable filter).Optical signal is sent out in beam splitting system
Add lustre to scattered, polychromatic light diverges to monochromatic light, and the light beam after dispersion enters 128 line element non-brake method indium gallium arsenic (inGaAs) two of detector
Photoelectric conversion is obtained electric signal by 16 A/D converters and generates image in a detector, obtains nature by pole pipe array
Absorptivity.And prompting in next step occurs in APP client.
6, sample is put into sample cell and is put into sample cell and adopted by the Fast nondestructive evaluation that can carry out drug sample at this time
Sample window, APP client click " detection ".Light source starting, light source emit stable near infrared light signal and reach sample to be tested simultaneously
And diffusing reflection occurs, optical signal enters in beam splitting system (linear variable filter).Dispersion occurs for optical signal in beam splitting system,
Polychromatic light diverges to monochromatic light, and the light beam after dispersion enters detector 128 line element non-brake method indium gallium arsenic (inGaAs) diode battle array
Column, obtain electric signal for photoelectric conversion by 16 A/D converters and generate image in a detector, obtain sample to be tested
Spectroscopic data.Spectroscopic data is uploaded to cloud database by APP client, such as drug meterological model, by comparing, obtain to
The qualitative or quantitative data of sample, qualitative data include nomenclature of drug, type and the place of production, quantitative data include drug effectively at
Point and adjunct ingredient content value.It is completed in 5 seconds by system optimization and Frame Design detection process.If you need to continue to test a little
That hits APP client continues to test button.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of portable near infrared spectrum detection system, including shell (1), the acquisition window (2) being arranged on shell, successively
It is mounted on detection light source (3), light-dividing device (4) and the detector being located along the same line in shell and with the acquisition window
(5), converter (6) and power supply unit (7), the output end of the detector and the converter are also equipped in the shell
Input terminal connection, the power supply unit are connect with detection light source, detector and converter respectively；It is characterized in that, further including sample
Product pond (21), the sample cell are mounted on the acquisition window, and the sample cell, which is divided into, sets sample portion (211) and fixed part
(212), described set is provided with lattice block (213) in sample portion, and the lattice block is provided centrally with through-hole (2131), the fixation
Portion is fixedly mounted on acquisition window；The light-dividing device is linear variable filter；
The portable near infrared spectrum detection system further includes micro-central controller (8) and the micro-central controller
The client (9) of connection is wirelessly communicated, the micro-central controller is mounted in shell, the micro-central controller and institute
It states power supply unit, detection light source, detector to connect with converter, after the micro-central controller converts the converter
Spectroscopic data is transmitted to client, and the control signal for receiving the client transmissions control the detection light source, detector and
The opening and closing of converter；
The client includes that the calibration module (91) successively chosen in order, the detection module (92) chosen and data show mould
Block (93)；Client is set to send a control signal to micro-central controller, the miniature center control by choosing calibration module
The calibration spectrum data of device receiving converter output, and the calibration spectrum data are exported to client, the data are shown
Module is for showing calibration spectrum data；Client is set to send a control signal to miniature center control by choosing detection module
Device, the detection spectroscopic data of micro-central controller receiving converter output, and by the detection spectroscopic data export to
Client, the data disaply moudle is for showing detection spectroscopic data.
2. a kind of portable near infrared spectrum detection system according to claim 1, which is characterized in that the through-hole it is straight
Diameter is 30~40mm, is connected with lid (11) on the shell, the lid is located at outside the sample cell.
3. a kind of portable near infrared spectrum detection system according to claim 1, which is characterized in that the detector is
128 line element non-brake method indium Ga-As diode array detectors, the converter are A/D converter；The light source is that double collection come true
Empty tungsten lamp.
4. a kind of portable near infrared spectrum detection system according to claim 1, which is characterized in that the power supply unit
For rechargeable battery, charging plug is installed on the shell.
5. a kind of portable near infrared spectrum detection system according to claim 1, which is characterized in that pacify on the shell
Equipped with power switch (71), the power switch is connect with the power supply unit.
6. a kind of portable near infrared spectrum detection system according to claim 1, which is characterized in that the linear gradient
The spectral region of optical filter is 900~1700nm.
7. a kind of portable near infrared spectrum detection system according to claim 1, which is characterized in that described portable close
Infrared spectroscopy detection system further includes cloud database (10), and the cloud database and the client wireless communicate to connect,
It is stored with the chemometric model of sample to be tested in the cloud database, the detection module is by the detection spectrum number
According to output to cloud database, the cloud database is by the chemistry of the detection spectroscopic data and sample to be tested that receive
Meterological model compares analysis and obtains the qualitative data and quantitative data of sample to be tested, and by the qualitative data and quantitative data
It is sent to data disaply moudle, the data disaply moudle is for showing qualitative data and quantitative data.
8. a kind of purposes of portable near infrared spectrum detection system, which is characterized in that the portable near infrared spectrum detection
System is the described in any item portable near infrared spectrum detection systems of claim 1~7, the portable near infrared spectrum
For detecting drug sample, the drug sample is added to be set in sample portion detection system.
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Cited By (1)
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| US12025496B2 (en) | 2021-10-15 | 2024-07-02 | InnoSpectra Corporation | Drug scanning and identification system and use method thereof |
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| CN107091805A (en) * | 2017-05-05 | 2017-08-25 | 成都宏志微纳光电技术有限公司 | A kind of method that use micro spectrometer detects sample |
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| CN109060717A (en) * | 2018-09-18 | 2018-12-21 | 赣州市检验检疫科学技术研究院 | The device that plastic products material scene based on near-infrared spectrum technique identifies |
| CN111257272B (en) * | 2020-03-02 | 2022-08-02 | 滕州市界河镇农业综合服务中心 | Portable potato detection device based on thing networking |
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