CN105647804B - Biometric print machine nozzle component and biometric print machine - Google Patents
Biometric print machine nozzle component and biometric print machine Download PDFInfo
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- CN105647804B CN105647804B CN201511030624.9A CN201511030624A CN105647804B CN 105647804 B CN105647804 B CN 105647804B CN 201511030624 A CN201511030624 A CN 201511030624A CN 105647804 B CN105647804 B CN 105647804B
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- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
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- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
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Abstract
A kind of biometric print machine nozzle component of the present invention, which is characterized in that first runner (1A is equipped in the nozzle component；2A) and second flow channel (1B；2B), the first runner (1A；Outlet and the second flow channel (1B 2A)；Outlet 2B) is adjacent, the second flow channel (1B；Outlet 2B) is constructed such that from the second material that it is sprayed towards from the first runner (1A；The first material movement that outlet 2A) comes out, so that from the second flow channel (1B；2B) the second material that outlet sprays with from the first runner (1A；2A) the first combination of materials that outlet sprays forms fluid print unit together.The biometric print machine nozzle component can guide auxiliary material to wrap up to protect cell, to reduce in print procedure due to being caused cellular damage by extrusion pressure and frictional force, and then improve the survival rate of cell, reliability with higher.
Description
Technical field
The present invention relates to biometric print field more particularly to a kind of biometric print machine nozzle components and biometric print machine.
Background technique
Biological 3D printing refers to the principle and method by 3D printing, by biomaterial (including natural biologic material and conjunction
At biomaterial or cell solution) three-dimensional structure of the printing as design, it is different from common 3D printing technique, biological 3D is beaten
The biological tissue of print technology production or organ also have certain biological function, need to mention for the further growth of cell and tissue
For condition, just because of above-mentioned characteristic, biological 3D printing technique is faced with many specific technical problems in development.
Wherein, in biological 3D printing field, it is known as cell three-dimensional printing technique, people for cell as the technology of printed material
Can use cell and biological prepared Chinese ink is made in biocompatible materials, spray head is mobile simultaneously to spray biological prepared Chinese ink, passes through program
Spray head movement printing bio-ink is controlled, biological prepared Chinese ink is beaten according to the three-dimensional building mathematical model of preset target print object
It is printed as type.
In the prior art for the nozzle that the spray head of biometric print is similar to syringe needle, which is directly installed on
Above biometric print machine.The ejecting device structure of such biometric print machine is simple, is mainly used to competent cell inserting bracket material
In material, but package can not be realized before the printing.Moreover, in the process that cell is directly ejected to print platform using spray head
In, extrusion pressure and nozzle wall can make the cell in biological prepared Chinese ink by bigger damage the frictional force of cell, thus
Can have an adverse effect to the survival rate of cell, and then influence the building of biological construct.
Summary of the invention
To overcome the above technological deficiency, the technical problem to be solved by the present invention is to provide a kind of biometric print machine nozzle component and
Biometric print machine can print simultaneously a variety of printed materials, it is further possible to make a variety of printed materials before printing
It combines, the second material is preferably used to be wrapped circumferentially around the first material as biological prepared Chinese ink, making it also has guarantor
The cell protected in the biological prepared Chinese ink sprayed is injury-free as far as possible.
In order to solve the above technical problems, first aspect present invention, which provides, is equipped with first runner and the in the nozzle component
The outlet of two runners, the first runner is adjacent with the outlet of the second flow channel, and the outlet of the second flow channel is configured to
Make to move from the second material that it is sprayed towards the direction of the first material sprayed from the outlet of the first runner, so that from institute
The second material that second flow channel outlet sprays is stated to export together with the first combination of materials sprayed and shape with from the first runner
At fluid print unit.
In this technical solution, the second material can be guided towards the direction of the first material and gradually be converged by second flow channel
It is poly-, thus by the second material together with the first combination of materials.Preferably the second material can be made to be wrapped in the first material, with shape
At the fluid print unit of biometric print material to be protected to cell, to reduce in print procedure due to being squeezed out
Pressure and frictional force and cause cellular damage.
Further, the second flow channel is at least partly tapered along towards its export direction.
In the improved technical solution, second flow channel is at least partly tapered, and can increase the pressure of the second material
To improve its flow velocity, so that flowing of second material in second flow channel is more smooth, and then more preferable in the exit of first runner
Wrap up the first material in ground.
Further, the second flow channel is tapered adjacent to the first runner exit
In the improved technical solution, second flow channel is tapered adjacent to the first runner exit, Neng Gou
Position adjacent to outlet applies pressure along towards the direction of the first material to the second material, to guide the second material towards the
The direction of one material sprays, to preferably wrap up the first material.
Further, the second flow channel is being intercepted adjacent to the first runner exit along towards its export direction
Section be taper.
In the improved technical solution, the Section Design that second flow channel is exported adjacent to first runner is taper, right
Second material has preferable guiding function, and flow velocity of second material on sustained height can be made identical, to make to reach
The flow velocity in second flow channel exit is also essentially identical, and then realizes that the second material equably wraps up the first material.
Further, biometric print machine nozzle component includes nozzle body and extension rod, the first runner and the spray
The outlet of head main body, the extension rod are arranged adjacent to the outlet of the nozzle body, the extension rod and the spray head master
The adjoining end face of body is equipped with open pocket, and the outlet of the nozzle body is extend into the open pocket, in the spray
Annular space between the outer wall of head main body and the inner wall of the open pocket is used as the second flow channel.
In the technical solution of the first embodiment, by being arranged gradually on extension rod and the adjoining end face of nozzle body
The open pocket of contracting, forms package chamber between the outlet of nozzle body and the outlet of open pocket, the second material can pass through spray
Second flow channel is formed between head body outer wall and open pocket and enters package chamber, and wraps up the first material sprayed from nozzle body
Material, to form fluid print unit, fluid print unit flows in the open pocket, and open pocket is conducive to convergence mixing
Fluid guarantees that the flow direction for wrapping up intracavitary fluid-mixing is more stable.
Further, the interior draft of the open pocket is greater than the outer draft of the nozzle body.
In the improved technology scheme of the first embodiment, the interior draft of open pocket is greater than the outer of the nozzle body
Draft can form tapered second between the inner wall of outer wall and open pocket that nozzle body is exported adjacent to first runner
Runner, to realize preferably package effect.
Further, in the exit of the second flow channel, the inner wall of the open pocket is lower than the nozzle body
Outer wall.
In the improved technology scheme of the first embodiment, the inner wall of open pocket is lower than the outer wall of nozzle body, in this way
The prolongation that open pocket is formed can be tapered further along the direction exported towards first runner, thus the second material of guidance
Material is further converged to the first material, more fully to wrap up the first material.
Further, biometric print machine nozzle component includes having the outer nozzle of first passage and in second channel
Nozzle, the inner nozzle are located in the first passage, and the second channel forms the first runner, in the outer nozzle
Inner wall and the inner nozzle outer wall between annular space be used as the second flow channel.
In the technical solution of the second embodiment, by using inside and outside two layers of nozzle arrangements, the second material can be guided
It is constantly converged to the first material during ejection, to wrap up in the exit of nozzle the first material, thus to the greatest extent
Amount avoids the first material from being damaged when spraying from jet expansion due to the effect of mechanical friction.
Further, in the exit of the second flow channel, the inner wall of the outer nozzle is lower than the outer wall of the inner nozzle.
In the improved technology scheme of the second embodiment, the inner wall of outer nozzle is lower than the outer wall of inner nozzle, spray outer in this way
Mouth prolongation can be tapered further along the direction exported towards first runner, so that the second material of guidance is further to the
One material convergence, so as to relatively reliable and fully wrap up the first material.
Further, the interior draft of the outer nozzle is greater than the outer draft of the inner nozzle.
In the improved technology scheme of the second embodiment, the interior draft of outer nozzle is greater than the outer draft of inner nozzle,
Second flow channel can be made to be tapered adjacent to first runner exit along towards the direction that first runner exports, to guide
Two materials during ejection further to center convergence, so that package be better achieved.
In order to solve the above technical problems, the present invention provides second aspects to provide a kind of biometric print machine, including above-mentioned
Biometric print machine nozzle component described in embodiment.
In the basic technical solution, biometric print machine can be by obtaining good biometric print material, to make
The various biological constructs of production keep higher activity and longer service life.
As a result, based on the above-mentioned technical proposal, the present invention provides a kind of biometric print machine nozzle components, pass through setting first
Runner and second flow channel, and keep the outlet of first runner adjacent with the outlet of second flow channel, and the outlet of second flow channel is constructed
At making to move from the second material that it is sprayed towards the direction of motion of the first material, can make to export the sprayed from second flow channel
The first material that two materials package is sprayed from first runner outlet, to form the fluid print unit of biometric print material to thin
Born of the same parents protect, to reduce in print procedure due to being caused cellular damage by extrusion pressure and frictional force, Jin Erti
The survival rate of high cell, reliability with higher.
Detailed description of the invention
The drawings described herein are used to provide a further understanding of the present invention, constitutes part of this application, this hair
Bright illustrative embodiments and their description for explaining only the invention, do not constitute improper limitations of the present invention.In the accompanying drawings：
Fig. 1 is the structural schematic diagram of the first embodiment of biometric print machine nozzle component of the present invention；
Fig. 2 is the structural schematic diagram of the second embodiment of biometric print machine nozzle component of the present invention；
Fig. 3 is the status diagram of fluid print unit outflow in second embodiment shown in Fig. 2.
Description of symbols
11- nozzle body；12- extension rod；13- heat preservation member；14- fixing body；1A- first runner；1B- second
Road；1C- wraps up chamber；1D- runner；1E- open pocket；
21- outer nozzle；The first guide portion of 21A-；The first main part of 21B-；22- inner nozzle；22A- second is guided
Portion；The second main part of 22B-；23- connecting tube；24- outer nozzle connector；25- main material runner pipe；2A- first runner；
2B- second flow channel.
Specific embodiment
Below by drawings and examples, technical scheme of the present invention will be described in further detail.
A specific embodiment of the invention be for the ease of to design of the invention, it is solved the technical issues of, constitute skill
The technical characteristic and bring technical effect of art scheme have further description.It should be noted that for these embodiment party
The explanation of formula does not constitute a limitation of the invention simultaneously.In addition, technology involved in the embodiment of present invention described below is special
Sign can be combined with each other as long as they do not conflict with each other.
Consider that the nozzle component of biometric print machine in the prior art can not before the printing realize cell to wrap up, this can be
The damage of cell is caused in print procedure, for this purpose, the present invention provides a kind of biometric print machine nozzle component, structure and principle
Embodiment referring to fig. 1 and fig. 2.In a schematical embodiment, first runner and second are equipped in nozzle component
Runner, first runner and second flow channel can convey congener biometric print material, can be used for different types of biology
Printed material, it can use, can also respectively be used alone simultaneously.
When first runner and second flow channel are respectively used to two kinds of materials simultaneously, first runner, which is used as, is used for biometric print material
Expect the flow channel of first material of (main material), stream of the second flow channel as the second material (auxiliary material) of wrapping biological printed material
Dynamic channel, first runner are 1A in Fig. 1, are 2A in Fig. 2, and it is 2B in Fig. 2 that second flow channel, which is 1B in Fig. 1,.Moreover,
The outlet of first runner and the outlet of second flow channel are adjacent, and the outlet of second flow channel is constructed such that the auxiliary material direction sprayed from it
The direction of motion of main material moves, and enables to the main material for exporting the auxiliary material sprayed from second flow channel with spraying from first runner outlet
It combines and forms fluid print unit, combined mode can be mixing, package or fusion etc., it is preferable that auxiliary material
Wrap up main material.
Fluid print unit is the print unit of biometric print material composition, e.g. wraps up main material by auxiliary material and is formed
Fluid-mixing print unit.About main material and auxiliary material, in a kind of most preferred embodiment, main material is printing containing cell
Material, auxiliary material are the printed materials for not including cell, and in this embodiment, most preferably, auxiliary material is with temperature-sensing property
Material, especially with temperature-sensing property and certain viscosity biocompatible materials, such as：The substances such as hydrogel.Another
In kind of embodiment, main material be do not include the printed material of cell, and auxiliary material is the printed material for including cell.At remaining
In embodiment, main material and auxiliary material are also possible to printed material all containing cell, can also all not contain the printing material of cell
Material.About the form of main material and auxiliary material, any or both is all one kind of following several forms：Homogeneous, it is heterogeneous (such as
Granular mixture), fluid continuously or discontinuously.
According to use demand, auxiliary material can be supplied with the substance of nutrition, and the substance for being also possible to supply bonding force (can dual-purpose
In formation protective layer), it can also make to provide the substance for being coated on and forming protective layer around main material.
The biometric print machine nozzle component of the embodiment, changes in the prior art in such a way that cell directly prints,
By setting first runner and second flow channel, and keep the outlet of first runner adjacent with the outlet of second flow channel, and second flow channel
Outlet be constructed such that from its spray auxiliary material towards main material the direction of motion move, can guide auxiliary material it is entire circumferential direction court
The direction of motion flowing of main material, to export the auxiliary material package sprayed from second flow channel from first-class using flow focusing principle
Road outlet spray main material, cell is protected with forming fluid print unit, thus reduce in print procedure due to by
Cellular damage, Jin Erti are caused to such as extrusion pressure of the external force by applications such as gases and nozzle inner walls bring frictional force
The survival rate of high cell, reliability with higher.
In order to realize the auxiliary material sprayed from second flow channel towards main material, can by second flow channel and first runner adjacent to
Respective exit is designed as the structure moved closer to each other, can specifically be realized by two kinds of following structure types, but not
It is limited to this.
In the first structure type, second flow channel adjacent to exit inner and outer wall towards main material the direction of motion all
It is tapered, and is parallel to each other.Optionally, second flow channel is isometrical, and in exit, second flow channel is tilted towards first runner
Extend, so that the second material in second flow channel is moved towards the first fluid convergence come out from first runner.
In second of structure type, second flow channel is at least partly tapered, and such structure can increase the pressure of auxiliary material
Power, to improve flow velocity so that flowing of the auxiliary material in second flow channel is more smooth, so the exit of first runner preferably
Wrap up main material.
It is further improved as second of structure type, second flow channel is adjacent to first runner exit along towards the
The direction of one runner exit is tapered.The embodiment can apply pressure along towards the direction of main material to auxiliary material, with guidance
Auxiliary material is sprayed towards the direction of main material, to preferably wrap up main material；But also can increase the pressure that auxiliary material is subject to, to improve
Flow velocity flows out auxiliary material more swimmingly to realize package.Those skilled in the art can be tapered by design second flow channel
Degree, to realize controllable package before the printing.
It is preferable to provide in form in one kind, second flow channel can be coaxially wrapped in except first runner, and second flow channel
It is spaced from each other between first runner, the form of coaxial arrangement is conducive to be wrapped in main material more uniformly except auxiliary material, to the greatest extent
The phenomenon that amount avoids uneven distribution, to form the higher fluid print unit of quality.
In another preferred embodiment, second flow channel adjacent to the first runner export along towards its mouthful
The section that direction is cut is taper, for example, in the embodiment shown in fig. 1, the inner and outer wall of second flow channel is back taper, and
The taper of second flow channel inner wall is less than the corresponding taper of outer wall；In the embodiment shown in Figure 2, the inner wall of second flow channel is column
Shape, outer wall are back taper.Taper is easy to process, and second flow channel be designed as taper compared to other shapes to fluid have compared with
Good guiding function, moreover it is possible to keep flow velocity of the auxiliary material on sustained height identical, to make the flow velocity for reaching second flow channel exit
Also essentially identical, and then realize that auxiliary material equably wraps up main material.
The embodiment that two types are capable of forming packaging type fluid print unit is presented below.
In the first embodiment, structural schematic diagram as shown in Figure 1, biometric print machine nozzle component include nozzle body 11
With extension rod 12, extension rod 12 is exported adjacent to nozzle body 11 to be arranged, and elongated runner 1D is equipped in extension rod 12, is flowed for making
Body print unit is directed ejection by runner 1D.By the way that elongated runner 1D is arranged in extension rod 12, fluid can be beaten
A possibility that impression member is oriented guidance and sequence, reduces obstruction；But also fluid can be protected to print during ejection
Unit reduces damage of the mechanical force to fluid print unit in print procedure, reliability with higher.Further, prolonging
Heat preservation member 13 can also be set on 12 periphery of stock, needed for heat preservation member 13 can guarantee that fluid print unit is kept in runner 1D
Temperature, to maintain the activity of fluid print unit, to overcome in the prior art the spray head of not extension rod that must stretch out one
Measured length, in order to apply ejection material, thus be not easy to heat preservation the technical issues of, temporarily without discovery spray head is entirely coated
The prior art of heat preservation module is used for 3D biometric print field, and 3D biometric print field due to main material (biometric print material) and
Auxiliary material (hydrogel) is very sensitive for temperature, have other technologies field not indispensable, stringent temperature control demand.
Fig. 1 can be referred to for the installation form of each component in the embodiment, extension rod 12 is being located at nozzle body 11 just
Lower section, nozzle body 11 and extension rod 12 can be coaxially located in fixing body 14.In the form of extension, extension rod 12 can be straight
It connects and is mounted in nozzle body 11 and is not provided with fixing body 14.
More specifically, extension rod 12 and the adjoining end face of nozzle body 11 are equipped with open pocket 1E, open pocket
The outlet of 1E is connected to runner 1D, and nozzle body 11 is extend into open pocket 1E, and the channel being arranged inside nozzle body 11 is made
For first runner 1A, the annular space between the outer wall of nozzle body 11 and the inner wall of open pocket 1E is used as second flow channel
1B.Moreover, forming package chamber 1C between the outlet of first runner 1A and the outlet of open pocket 1E, exported from second flow channel 1B
The auxiliary material of the ejection main material that package is sprayed from the outlet first runner 1A in package chamber 1C, to form fluid print unit.Fluid
Print unit flows in open pocket 1E, and using flow focusing principle, main material is gradually passed through after auxiliary material is uniformly wrapped up from the chamber
Room is discharged into runner 1D.Open pocket 1E is conducive to converge fluid-mixing, guarantees the stream of fluid print unit in package chamber 1C
To more stable.
In such an embodiment, it is preferable the interior draft of open pocket 1E is greater than the outer draft of nozzle body 11, in this way
Tapered second flow channel can be formed between the inner wall of outer wall and open pocket that nozzle body is exported adjacent to first runner, from
And realize preferably package effect.
Such as：In the first structure, the outer wall of nozzle body 11 and the inner wall of open pocket 1E are back taper, and are sprayed
The taper of the outer wall of head main body 11 is less than the taper of open pocket 1E inner wall, enables to auxiliary material recessed along nozzle body 11 and opening
Annular space flowing between the conical surface of portion 1E, plays preferable guiding function, is conducive to auxiliary material to the uniform package of main material.?
In second of structure, 11 outer wall of nozzle body is cylindricality, and open pocket 1E inner wall is back taper, also be may be implemented tapered to play
The effect of convergence.
For above-mentioned first embodiment and improvement project, main material and auxiliary material can be wrapped in the exit of corresponding runner
It wraps up in, it is preferable that in the exit of second flow channel 1B, the inner wall of open pocket 1E is lower than the outer wall of nozzle body 11, in this way can be with
The outlet of second flow channel 1B is set to be lower than the outlet of first runner 1A, the prolongation that open pocket 1E is formed can be further along
The direction exported towards first runner 1A is tapered, to guide auxiliary material further to converge to main material, so as to relatively reliable and abundant
Wrap up main material in ground.For a kind of specific structure, if 11 outer wall of nozzle body is taper, and open pocket 1E inner wall is back taper
Shape then needs to make the outlet of second flow channel 1B to be lower than the outlet of first runner 1A, is just able to guide auxiliary material and converges to main material.
It is former to the work of such biometric print machine nozzle component of the present invention below in conjunction with first embodiment shown in FIG. 1
Reason is illustrated.Main material enters package chamber 1C after the ejection of nozzle body 11, and auxiliary material is recessed by 11 outer wall of nozzle body and opening
The second flow channel 1B formed between portion's 1E inner wall enters package chamber 1C, and the auxiliary material wrapped up in chamber 1C has certain pressure, pressure
The adjustable auxiliary material wrapping layer of size thickness, and auxiliary material compressing is attached to the master of a part exposed by nozzle body 11
Material enters main material under the continuous package of auxiliary material and prolongs until auxiliary material all wraps up main material after entire main material sprays
The runner 1D of stock 12, the main material wrapped up by auxiliary material are flowed in elongated runner 1D interior orientation, while uniformly being wrapped up and orderly
Discharge.
In a second embodiment, structural schematic diagram as shown in Figure 2, biometric print machine nozzle component include having first to lead to
The outer nozzle 21 in road and inner nozzle 22 with second channel, inner nozzle 22 are located in first passage, and second channel forms the
One runner 2A, the annular space between the inner wall of outer nozzle 21 and the outer wall of inner nozzle 22 are used as second flow channel 2B.
Preferably, the interior draft of outer nozzle 21 is greater than the outer draft of inner nozzle 22, can make second flow channel 2B in this way
It is tapered adjacent to the exit first runner 2A, can guide auxiliary material during ejection further to center convergence, from
And main material is wrapped up in the exit of inner nozzle 22, to avoid main material when spraying from outlet due to mechanical friction as far as possible
It acts on and is damaged.Figure it is seen that outer wall of the inner nozzle 22 adjacent to outlet is cylindricality, outer nozzle 21 is adjacent to out
The inner wall of mouth is taper, is tapered to realize second flow channel 2B in the position adjacent to outlet.In addition, inner nozzle 22 is adjacent
The outer wall for being bordering on outlet is also possible to taper, and the taper for needing to meet 22 outer wall of inner nozzle is small in the position adjacent to outlet
In the taper of 21 inner wall of outer nozzle.
Preferably, outer nozzle 21 and inner nozzle 22 are coaxially disposed, and are formed the tactic pattern of concentric bilayer, can be made second in this way
Runner is more uniform to the package of main material.
In general, in the exit of second flow channel 2B, the outer wall of the inner wall of outer nozzle 21 and inner nozzle 22 can be set
It is calculated as concordant form.More preferably, in the exit of second flow channel 2B, the inner wall of outer nozzle 21 is lower than the outer wall of inner nozzle 22,
21 prolongation of outer nozzle can be tapered further along the direction exported towards first runner 2A in this way, thus guide auxiliary material after
Continue and converged to main material, so as to relatively reliable and fully wrap up main material.
A kind of concrete implementation structure is given below, as shown in Fig. 2, outer nozzle 21 includes the first guide portion 21A and first
Main part 21B, inner nozzle 22 include the second guide portion 22A and the second main part 22B, the first guide portion 21A and the second guide portion
22A is arranged adjacent to the outlet of corresponding nozzle, and the annular space between the first guide portion 21A and the second guide portion 22A is along direction
The direction of jet expansion is tapered.In addition, the corresponding section at the first guide portion 21A first runner 2A is pipe running system, it is best
It can pass through for single-row main material (such as cell prepared Chinese ink unit), to guide main material more swimmingly to spray and be wrapped up by auxiliary material, thus
It is formed and meets the particular biological printed material that printing requires.
In the specific structure type, the first main part 21B includes the first cylindrical portion and the first conus portion, the first circular cone
Portion is connected between the first guide portion 21A and the first cylindrical portion, the first cylindrical portion by be threadedly engaged or other fastening means with
Outer nozzle connector 24 connects, and outer nozzle connector 24 is equipped with connecting tube 23, for auxiliary material to be introduced second flow channel 2B.Second
Main part 22B includes the second cylindrical portion and the second conus portion, and the second conus portion is connected to the second guide portion 22A and the second cylindrical portion
Between, the second cylindrical portion is by being threadedly engaged or other fastening means are connect with main material runner pipe 25.Wherein, the second conus portion rises
To transitional function, from large to small by the sectional area of first runner 2A, required so that main material be made to be changed into satisfaction printing in outflow
Fluid print unit, the design of the first conus portion be in order to the second conus portion be adapted, thus to auxiliary material play guidance make
With.As one more preferably embodiment, second flow channel 2B be tapered between the first conus portion and the second conus portion so that auxiliary
Material pressure increases, and flow velocity increases.The reason is that, according to formula Q=μ * A* (△ P/ ρ) ^0.5, Q of the spout flow of spray head
For flow, μ is coefficient, and A is the cross-sectional area of spout, and △ P is pressure difference, and ρ is fluid density.Meanwhile Q=vA, v are flow velocitys.
One timing of pressure of containers, flow is certain.The parameter so changed in runner is respectively：Cross-sectional area, pressure
Strong poor, flow velocity.Relationship between them can be understood generally as：When cross section reduces, then pressure is big and flow velocity is fast.Therefore in runner
Just there is opposite higher-pressure region and low-pressure area in local location, and the flow velocity of higher-pressure region is greater than the flow velocity of low-pressure area, but flow
It is constant.
To sum up, here by cross section is reduced, so that pressure increases, flow velocity is accelerated.To make auxiliary material in second flow channel 2B
Interior flowing is more smooth, it is not easy to block, and more abundant in package of the exit to main material.
Below in conjunction with second embodiment shown in Fig. 2, the working principle of such nozzle component of the present invention is carried out detailed
Explanation.Under the control of pressure, main material is flowed along first runner 2A, and auxiliary material is flowed along tapered second flow channel 2B, and is had
There is certain pressure, it is gradually real on reaching the main material for being attached to when the outlet of second flow channel 2B and reaching the outlet first runner 2A
It all now is wrapped to form fluid print unit, is finally sprayed in an orderly manner from the outlet of nozzle component.
For two kinds of embodiment above-mentioned, it is required to realize the stream of biometric print material by pressure control
It is dynamic, such as pressure control.After installing material in main material container and auxiliary material container, connect respectively with the electric Proportion valve in gas circuit
It connects, two corresponding electric Proportion valves of container carry out real-time analog quantity communication with control system again, send out through upper software
It instructs and the extrusion output of two containers is controlled out respectively.By adjusting air pressure respectively, first runner and second can control
The spouting velocity of fluid in road.
According to different printing demands, different control modes can be taken.When needing to form continuous biometric print material
When material, main material can be added in main material container, add auxiliary material in auxiliary material container, by applying constant air pressure, so that it may
Main material is set to continue to spray, outside is wrapped up by auxiliary material, integral into elongate structure.As shown in figure 3, when needing to form particle
When the biometric print material of shape, main material can be added in main material container, add auxiliary material in auxiliary material container, by frequently adding
Pressure forms pulse with on-off action, and main material forms particle under the action of pulse, and in conjunction with outer layer auxiliary material, forms similar yolk
The structure of egg white, and rapid cooling and shaping under the influence of temperature.
In addition, the present invention also provides a kind of biometric print machines comprising above-mentioned biometric print machine nozzle component, due to
Biometric print machine nozzle component of the present invention can wrap up cell in printing, to carry out being protected from damage to cell
Wound, survival rate with higher, thus also have corresponding advantageous effects using the biometric print machine of such nozzle component,
Can by obtain good biometric print material so that the various biological constructs of production be able to maintain higher activity and compared with
The long service life.Preferably, biometric print machine is 3D biometric print machine, and biometric print machine nozzle component of the present invention is particularly suitable for 3D
Biometric print machine.
A kind of biometric print machine nozzle component provided by the present invention and biometric print machine are described in detail above.
Principle and implementation of the present invention are described for specific embodiment used herein, and the explanation of above embodiments is only
It is to be used to help understand method and its core concept of the invention.It should be pointed out that for those skilled in the art
For, it without departing from the principle of the present invention, can be with several improvements and modifications are made to the present invention, these improve and repair
Decorations are also fallen within the protection scope of the claims of the present invention.
Claims (9)
1. a kind of biometric print machine nozzle component, which is characterized in that including nozzle body (11) and extension rod (12), the spray head
First runner (1A is equipped in component；2A) and second flow channel (1B；2B), the first runner (1A；Outlet 2A) and described the
Two runner (1B；Outlet 2B) is adjacent, the second flow channel (1B；It is at least partly 2B) tapered along towards its export direction
, so that the second flow channel (1B；Outlet 2B) is constructed such that from the second material that it is sprayed towards from described first-class
Road (1A；The first material movement that outlet 2A) comes out, so that from the second flow channel (1B；2B) the second material that outlet sprays
With from the first runner (1A；2A) the first combination of materials that outlet sprays forms fluid print unit together；
The outlet of the first runner (1A) and the nozzle body (11), the neighbouring spray head master of the extension rod (12)
The outlet of body (11) is arranged, and the extension rod (12) and the nozzle body (11) adjoining end face are equipped with open pocket
The outlet of (1E), the nozzle body (11) are extend into the open pocket (1E), the outer wall in the nozzle body (11)
Annular space between the inner wall of the open pocket (1E) is used as the second flow channel (1B)；The nozzle body (11)
The inner wall of outer wall and the open pocket (1E) is back taper, and the interior draft of the open pocket (1E) is greater than the spray head
The outer draft of main body (11), so that the neighbouring first runner (1A of the nozzle body (11)；2A) outer wall exported is opened with described
Tapered second flow channel (1B is formed between the inner wall in stomatodeum portion (1E)；2B)；
It is additionally provided with heat preservation member (13) on the extension rod (12) periphery, the heat preservation member (13) is for guaranteeing fluid print unit
Temperature needed for keeping.
2. biometric print machine nozzle component according to claim 1, which is characterized in that the second flow channel (1B；2B) exist
Adjacent to the first runner (1A；2A) exit is tapered.
3. biometric print machine nozzle component according to claim 2, which is characterized in that the second flow channel (1B；2B) exist
Adjacent to the first runner (1A；2A) exit is taper along the section intercepted towards its export direction.
4. biometric print machine nozzle component according to claim 1, which is characterized in that the second flow channel (1B；2B) with
First runner (the 1A；2A) moved closer to each other adjacent to respective exit.
5. biometric print machine nozzle component according to claim 1, which is characterized in that in going out for the second flow channel (1B)
At mouthful, the inner wall of the open pocket (1E) is lower than the outer wall of the nozzle body (11).
6. biometric print machine nozzle component according to claim 1, which is characterized in that including the outer spray with first passage
Mouth (21) and inner nozzle (22) with second channel, the inner nozzle (22) are located in the first passage, and described second
Channel forms the first runner (2A), the ring between the inner wall of the outer nozzle (21) and the outer wall of the inner nozzle (22)
Shape space is used as the second flow channel (2B).
7. biometric print machine nozzle component according to claim 6, which is characterized in that in going out for the second flow channel (2B)
At mouthful, the inner wall of the outer nozzle (21) is lower than the outer wall of the inner nozzle (22).
8. biometric print machine nozzle component according to claim 6, which is characterized in that the inner wall of the outer nozzle (21) is oblique
Degree is greater than the outer draft of the inner nozzle (22).
9. a kind of biometric print machine, which is characterized in that including biometric print machine nozzle component described in claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201511030624.9A CN105647804B (en) | 2015-12-30 | 2015-12-30 | Biometric print machine nozzle component and biometric print machine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511030624.9A CN105647804B (en) | 2015-12-30 | 2015-12-30 | Biometric print machine nozzle component and biometric print machine |
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| CN105647804A CN105647804A (en) | 2016-06-08 |
| CN105647804B true CN105647804B (en) | 2018-11-23 |
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| CN113059793A (en) | 2019-12-30 | 2021-07-02 | 四川蓝光英诺生物科技股份有限公司 | Biological printer nozzle, biological printer and method for printing lumen tissue construct |
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| US7938341B2 (en) * | 2004-12-13 | 2011-05-10 | Optomec Design Company | Miniature aerosol jet and aerosol jet array |
| EP1851112B1 (en) * | 2005-02-23 | 2014-05-28 | Norden Machinery Ab | Filling nozzle |
| CN104441654B (en) * | 2014-10-27 | 2016-08-24 | 清华大学深圳研究生院 | A kind of three dimensional biological printing equipment and method |
| CN204839829U (en) * | 2015-05-07 | 2015-12-09 | 周惠兴 | Shower nozzle device and parcel system with automatically, wrap up function |
| CN105167879B (en) * | 2015-06-25 | 2017-08-22 | 南京律动生物科技有限公司 | A kind of double-channel nozzle |
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