CN105624241A - Fermentation technology of A40926 antibiotic - Google Patents
Fermentation technology of A40926 antibiotic Download PDFInfo
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- CN105624241A CN105624241A CN201410587242.5A CN201410587242A CN105624241A CN 105624241 A CN105624241 A CN 105624241A CN 201410587242 A CN201410587242 A CN 201410587242A CN 105624241 A CN105624241 A CN 105624241A
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- fermentation
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- valine
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Abstract
The invention discloses a fermentation technology of A40926 antibiotic. The fermentation technology comprises the following steps: step 1, inoculating a strain into a fermentation medium, and carrying out fermentation culture, wherein the fermentation culture time is 120h-150h, the fermentation medium is prepared from the following components in percentage by weight: 1.3%-1.5% of glucose, 0.2-0.5% of dextrin, 0.8%-1% of corn starch, 1%-2% of meat peptone, 1%-3% of yeast extract powder, and 0.2%-1% of valine. The fermentation technology has the advantages that the fermentation level is high, the operation is simple, the cost is low, and large-scale production can be realized.
Description
Technical field
The present invention relates to a kind of antibiotic fermentation technology of A40926, belong to biological technical field.
Background technology
At present Study on Fermentation is produced for A40926 less, and existing A40926 yield is very low obviously can not meet requirement, in view of existing A40926 fermentation process be simply limited to medicine bottle experiment and fermentation unit is low, play the requirement less than productionization. Accordingly, it would be desirable to seek a kind of new technology to solve this problem.
Summary of the invention
It is an object of the invention to: a kind of antibiotic fermentation technology of A40926 is provided.
For achieving the above object, the technical solution used in the present invention is: a kind of antibiotic fermentation technology of A40926, step one: strain is inoculated in fermentation medium and carries out fermentation culture, wherein fermented incubation time is 120h-150h, described fermentation medium is glucose, dextrin, corn starch, meat peptone, yeast leaching powder and valine, wherein in fermentation medium, mass ratio shared by a component is respectively as follows: glucose is 1.3%-1.5%, dextrin is 0.2%-0.5%, corn starch is 0.8%-1%, meat peptone is 1%-2%, yeast leaching powder is 1%-3%, valine is 0.2%-1%.
The temperature of fermentation culture is 25 DEG C-35 DEG C.
The pH value of fermentation culture is 6.0-8.0.
Due to the application of technique scheme, the present invention compared with prior art has the advantage that the fermentation technology fermentation level of the A40926 of the present invention is high, simple to operate, and cost is low, it is possible to produce on a large scale.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment one:
The antibiotic fermentation technology of a kind of A40926 of the present invention, step one: strain is inoculated in fermentation medium and carries out fermentation culture, wherein fermented incubation time is 120h, described fermentation medium is glucose, dextrin, corn starch, meat peptone, yeast leaching powder and valine, wherein in fermentation medium mass ratio shared by a component be respectively as follows: glucose be 1.3%, dextrin be 0.2%, corn starch be 0.8%, meat peptone be 1%, yeast leaching powder be 1%, valine be 0.2%.
The temperature of fermentation culture is 25 DEG C.
The pH value of fermentation culture is 6.0.
The fermentation technology fermentation level of the A40926 of the present invention is high, simple to operate, and cost is low, it is possible to produce on a large scale.
Embodiment two:
The antibiotic fermentation technology of a kind of A40926 of the present invention, step one: strain is inoculated in fermentation medium and carries out fermentation culture, wherein fermented incubation time is 135h, described fermentation medium is glucose, dextrin, corn starch, meat peptone, yeast leaching powder and valine, wherein in fermentation medium mass ratio shared by a component be respectively as follows: glucose be 1.4%, dextrin be 0.35%, corn starch be 0.9%, meat peptone be 1.5%, yeast leaching powder be 2%, valine be 0.6%.
The temperature of fermentation culture is 30 DEG C.
The pH value of fermentation culture is 7.0.
The fermentation technology fermentation level of the A40926 of the present invention is high, simple to operate, and cost is low, it is possible to produce on a large scale.
Embodiment three:
The antibiotic fermentation technology of a kind of A40926 of the present invention, step one: strain is inoculated in fermentation medium and carries out fermentation culture, wherein fermented incubation time is 150h, described fermentation medium is glucose, dextrin, corn starch, meat peptone, yeast leaching powder and valine, wherein in fermentation medium mass ratio shared by a component be respectively as follows: glucose be 1.5%, dextrin be 0.5%, corn starch be 1%, meat peptone be 2%, yeast leaching powder be 3%, valine be 1%.
The temperature of fermentation culture is 35 DEG C.
The pH value of fermentation culture is 8.0.
The fermentation technology fermentation level of the A40926 of the present invention is high, simple to operate, and cost is low, it is possible to produce on a large scale
Although embodiment of the present invention are disclosed as above, but listed utilization that it is not restricted in description and embodiment, it can be applied to various applicable the field of the invention completely, for those skilled in the art, it is easily achieved other amendment, therefore under the general concept limited without departing substantially from claim and equivalency range, the present invention be not limited to specific details and shown here as with description.
Claims (3)
1. the antibiotic fermentation technology of A40926, it is characterized in that, step one: strain is inoculated in fermentation medium and carries out fermentation culture, wherein fermented incubation time is 120h-150h, described fermentation medium is glucose, dextrin, corn starch, meat peptone, yeast leaching powder and valine, and wherein in fermentation medium, mass ratio shared by a component is respectively as follows: glucose to be 1.3%-1.5%, dextrin be 0.2%-0.5%, corn starch is 0.8%-1%, meat peptone is 1%-2%, yeast leaching powder is 1%-3%, valine is 0.2%-1%.
2. a kind of antibiotic fermentation technology of A40926 according to claim 1, it is characterised in that: the temperature of fermentation culture is 25 DEG C-35 DEG C.
3. a kind of antibiotic fermentation technology of A40926 according to claim 1, it is characterised in that: the pH value of fermentation culture is 6.0-8.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410587242.5A CN105624241A (en) | 2014-10-28 | 2014-10-28 | Fermentation technology of A40926 antibiotic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410587242.5A CN105624241A (en) | 2014-10-28 | 2014-10-28 | Fermentation technology of A40926 antibiotic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105624241A true CN105624241A (en) | 2016-06-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410587242.5A Pending CN105624241A (en) | 2014-10-28 | 2014-10-28 | Fermentation technology of A40926 antibiotic |
Country Status (1)
| Country | Link |
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| CN (1) | CN105624241A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110551786A (en) * | 2019-09-12 | 2019-12-10 | 浙江海正药业股份有限公司 | Fermentation medium for increasing yield of A40926B 0 and method thereof |
-
2014
- 2014-10-28 CN CN201410587242.5A patent/CN105624241A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110551786A (en) * | 2019-09-12 | 2019-12-10 | 浙江海正药业股份有限公司 | Fermentation medium for increasing yield of A40926B 0 and method thereof |
| CN110551786B (en) * | 2019-09-12 | 2021-12-07 | 浙江海正药业股份有限公司 | Fermentation medium for increasing yield of A40926B 0 and method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160601 |
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| WD01 | Invention patent application deemed withdrawn after publication |