CN105617084A - Medicine for treating candidal vaginitis - Google Patents

Abstract

The invention discloses a medicine for treating candidal vaginitis. The medicine comprises an externally used medicine and an oral medicine, wherein the externally used medicine comprises 30-40 parts of a spartina alterniflora extract, 6-8 parts of a motherwort extract and 115-125 parts of a suppository matrix material; the oral medicine comprises wheat germ, corn germ, phoenix-tail fern, poria cocos, cortex phellodendri and ligusticum wallichii; the oral medicine is prepared by the following process: mixing the wheat germ, the corn germ, the phoenix-tail fern, the poria cocos, the cortex phellodendri and the ligusticum wallichii, micro-pulverizing, sieving by a 10-mesh sieve, and discarding bulky materials to form raw materials; adding water, uniformly mixing, homogenizing by using a 20MPa homogenizer, and then performing spray drying to obtain powdery particles; then adding cellulase for performing first enzymolysis for 100 minutes at the temperature of 70-75 DEG C to obtain enzymatic hydrolyzate; rapidly heating to 100 DEG C and keeping the temperature for 5 minutes, then rapidly cooling to 65-70 DEG C, sequentially homogenizing by using five homogenizers, and then performing spray drying to obtain final powdery particles. The medicine has a very good therapeutic effect on the candidal vaginitis through oral administration and external use.

Description

A kind of medicine treating monilial vaginitis

Technical field

The present invention relates to a kind of medicine treating monilial vaginitis.

Background technology

Monilial vaginitis is a kind of common infectious diseases in genital tract, and clinical symptoms shows as leucorrhoea grow in quantity, pudendum, pruritus of vagina, burning sensation, painful urination, Chang Fahong, edema around pudendum more, causes the multiformity that epidermis changes. Also may result in very shallow vesicle pimple or eczema shape rotten to the corn, ulcer time serious, can be caused, in general female its infection rate can 15%, pregnancy women increases due to vagina glycogen, and acidity strengthens makes this disease prevalence higher. According to relevant bibliographical information, infection of pregnant women rate may be up to 55%, is more common in anemia of pregnant woman and diabetics.

Summary of the invention

For above-mentioned prior art Problems existing, the present invention provides a kind of medicine treating monilial vaginitis, and therapeutic effect is good, and has no side effect.

To achieve these goals, the technical solution used in the present invention is: a kind of medicine treating monilial vaginitis, it is characterised in that include medicine for external use and oral medicine.

Spartina alterniflora's extract 30��40 parts, Herba Leonuri extract 6-8 part, 115��125 parts of suppository base material, suppository base material is semi-synthetic fatty acid glyceride

The processing technology of the extract of described Spartina alterniflora is 1) by the Spartina alterniflora after vacuum drying, pulverize in pulverizer and obtain Spartina alterniflora's powder, Spartina alterniflora, powder are placed in the extraction kettle of supercritical extraction; 2) use supercritical CO 2 as solvent, concentration be 60% ethanol do entrainer; 3) regulating extraction kettle extracting pressure to be controlled at 20��35MPa, temperature controls at 35 DEG C, and CO2 flow-control is at 9L/h, and extraction time controls at 2h, obtains brown paste Spartina alterniflora's extract.

Described oral medicine includes: Fructus Tritici aestivi, Fructus Maydis, Herba Pteridis Multifidae, Poria, Cortex Phellodendri, Rhizoma Chuanxiong.

Described oral medicine technique is:

(1) 11 portions of Fructus Tritici aestivis, 11 parts of Fructus Maydiss, 21 parts of Herba Pteridis Multifidaes, 18 parts of Poria, 11 parts of Cortex Phellodendris, 9 parts of Rhizoma Chuanxiong mixing are carried out Crushing of Ultrafine, and sieve with the screen cloth of 10 orders, discard thick raw material and form raw material; Add water Homogeneous phase mixing carry out homogenizing by 20 MPas of homogenizers, then carries out spray drying, obtains powdered granule;

(2) above-mentioned powdered granule adding 18 parts of distillation hydro-thermals to 70-75 DEG C, the cellulase being subsequently adding 0007 part carries out enzymolysis, and in this process, temperature maintains 70-75 DEG C,

100 minutes persistent period, obtain enzymolysis solution; It is brought rapidly up to 100 DEG C and keeps 5 minutes, being then cooled to rapidly 65-70 DEG C, and passing sequentially through five homogenizers and carry out homogenizing, then carrying out spray drying, finally obtain powdered granule.

Five described homogenizer pressure are respectively as follows: 30 MPas, 65 MPas, 55 MPas, and 40 MPas, 65 MPas, granulation outcome is good, and product is instant effective.

The invention has the beneficial effects as follows: in oral medicine production process, Fructus Tritici aestivi, Fructus Maydis enzymolysis produce the big peptide of little galanin peptide, 5% maltodextrin, starch, enzymolysis cellulose produce oligosaccharide polysaccharide fine cellulose, emulsifying is abundant, and it is coated with Herba Pteridis Multifidae, Poria, Cortex Phellodendri, Rhizoma Chuanxiong micropowder granule, diameter is at 15 microns, and good being prone to absorbs micro encapsulation effect; Significantly improve mouthfeel simultaneously. By the comprehensive use of oral medicine and medicine for external use, the therapeutical effect created, oral medicine can improve body's immunity activity, and humoral and cellular immune response is had facilitation; Energy chemotactic leukocyte, induction local macrophage strengthens its phagocytic function and hydrolysing activity, it is stimulated to produce lymphokine and inflammatory mediator, and then the anti-infection ability of enhancing body, medicine for external use is the extract of Spartina alterniflora and a small amount of Herba Leonuri extract, plays the effect such as antiinflammatory, anti-Grain-positive pathogenic bacteria, can strengthen the pathogenic bacteria phagocytic function of patient's macrophage, improve patient's immunity, for the therapeutic effect that monilial vaginitis has had.

Detailed description of the invention

Example of the present invention is the description of the invention and can not limit the present invention, any change in the implication suitable with the present invention and scope and adjustment, is all considered as within the scope of the invention.

Embodiment 1

Medicine for external use includes:

The processing technology of the extract of Spartina alterniflora is 1) by the Spartina alterniflora after vacuum drying, pulverize in pulverizer and obtain Spartina alterniflora's powder, Spartina alterniflora, powder are placed in the extraction kettle of supercritical extraction; 2) use supercritical CO 2 as solvent, concentration be 60% ethanol do entrainer; 3) regulating extraction kettle extracting pressure to be controlled at 35MPa, temperature controls at 35 DEG C, and CO2 flow-control is at 9L/h, and extraction time controls at 2h, obtains brown paste Spartina alterniflora's extract.

Consumption represents with weight portion, Spartina alterniflora's extract 30 parts, Herba Leonuri extract 8 parts, suppository base material semi-synthetic fatty acid glyceride 115 parts, melts suppository base material water-bath, condenses to room temperature, add Spartina alterniflora's extract, Herba Leonuri extract, mixing, filling mould, solidification rear demoulding, packaging, suppository specification is 2g/ grain.

Oral medicine technique is:

(1) by broken to 11 portions of Fructus Tritici aestivis, 11 parts of Fructus Maydiss, 21 portions of Herba Pteridis Multifidaes, 18 parts of Poria, 11 portions of Cortex Phellodendris, 9 parts of Rhizoma Chuanxiong micropowders, and sieve with the screen cloth of 10 orders, discard thick raw material and form raw material; Add water Homogeneous phase mixing carry out homogenizing by 20 MPas of homogenizers, then carries out spray drying, obtains powdered granule;

(2) above-mentioned powdered granule adding 18 parts of distillation hydro-thermals to 5 DEG C, the cellulase being subsequently adding 0007 part carries out enzymolysis, and in this process, temperature maintains 75 DEG C,

100 minutes persistent period, obtain enzymolysis solution; It is brought rapidly up to 100 DEG C and keeps 5 minutes, being then cooled to rapidly 70 DEG C, and passing sequentially through five homogenizers and carry out homogenizing, then carrying out spray drying, finally obtain powdered granule. Five described homogenizer pressure are respectively as follows: 30 MPas, 65 MPas, 55 MPas, 40 MPas, 65 MPas.

Comparative example 1: medicine for external use in the same manner as in Example 1, oral medicine: Fructus Tritici aestivi, Fructus Maydis, Herba Pteridis Multifidae, Poria, Cortex Phellodendri, Rhizoma Chuanxiong traditionally Traditional medicine infusion method boils.

Comparative example 2: in medicine for external use, is: Spartina alterniflora's extract 10 parts, Herba Leonuri extract 28 parts that suppository base material semi-synthetic fatty acid glyceride 115 parts, oral medicine is consistent with embodiment by weight proportion.

Comparative example 3: for the medicine for external use in embodiment 1.

Comparative example 4: for the oral medicine in embodiment 1.

Contrast test

Choose 100 example monilial vaginitis patients as the object of observation. 19 years old��47 years old age, average out to 33.1 years old. 100 examples are randomly divided into four groups, and four groups of patient's zero differences (P > 0.05) in the general clinical data such as age, disease degree, therefore two groups of patients have comparability. All patients all have colpitis mycotica recurrent exerbation medical history, use Western medicine and general treatment by Chinese herbs DeGrain. The diagnostic criteria that all 100 example patients are satisfied by " new Chinese medicine guideline of clinical investigations " about monilial vaginitis: 1. leucorrhoea grow in quantity, pudendum, pruritus of vagina, burning sensation, the symptom such as painful urination; 2. vagina or cervical mucosa are congested, have the secretions of bean curd scoriform; 3. through secretions plate coating checking, it has been found that candidiasis or cultivation are positive; 4. recurrent exerbation person after western medicine routine treatment. 100 examples are randomly divided into four groups, and four groups of patient's zero differences (P > 0.05) in the general clinical data such as age, disease degree, therefore four groups of patients have comparability.

Curative effect judgment criteria

If the clinical symptoms of patient and sign are wholly absent, secretions recovery is normal, and after clean period, transvaginal secretions smear detection in 3��7 days is normal, and continuous detecting is then all normally for 3 times cure; If the clinical symptoms of patient and sign are obviously improved, secretions recovers normal substantially, 3��7 days transvaginal secretions smear detection only accidental mycetes after clean period, and continuous detecting is also only for 3 times that accidental mycete is then for effective; If the clinical symptoms of patient and sign are not obviously improved, secretions is abnormal, and after clean period, 3��7 days transvaginal secretions carries out smear detection, and continuous detecting all finds have mycete then for invalid for 3 times. Always effectively=cure+effective.

Therapeutic Method

Embodiment 1 group of patient clean up pudendum, remove secretion foreign body, vagina to medicine for external use, one time 1,1 time on the one. Oral medicine for external use, twice on the one, each electuary 20g.

Comparative example 1 group: medicine for external use in the same manner as in Example 1, oral medicine: Fructus Tritici aestivi, Fructus Maydis, Herba Pteridis Multifidae, Poria, Cortex Phellodendri, Rhizoma Chuanxiong traditionally Traditional medicine infusion method boils.

Comparative example 2 groups: in medicine for external use, is: Spartina alterniflora's extract 10 parts, Herba Leonuri extract 28 parts that suppository base material semi-synthetic fatty acid glyceride 115 parts, oral medicine is consistent with embodiment by weight proportion.

Comparative example 3 groups: only take and the oral medicine in embodiment 1.

Comparative example 4 groups: only take and the medicine for external use in embodiment 1.

Patient all forbids taking other medicine during treating, and keeps the spatter property of pudendum, forbids having sexual intercourse thing, bath in a tub etc. in addition during treatment. Within the 3rd day to 3rd month patient menstrual, according to the situation of change of its cervix uteri local and the improvement situation of other clinical symptoms, therapeutic effect is added up.

1.5 statistical analysis

Adopting SPSS12.0 software that data are carried out statistical procedures analysis, wherein continuous data data adopts t inspection, and enumeration data adopts �� 2 to test, and P < 0.05 is that difference is statistically significant.

2 results

Embodiment P < 0.01 compared with four groups of comparative examples is that difference is statistically significant.

Group	Effective	Effectively	Invalid	Total effective
					Embodiment	18	5	2	23
Comparative example 1	3	2	20	5
					Comparative example 2	5	2	18	7
Comparative example 3	4	7	13	11
					Comparative example 4	3	3	19	6

Mouthfeel contrasts: embodiment 1 mouthfeel is without bitterness; Comparative example 1 mouthfeel is pained.

Patient's average course of disease comparing difference statistically significant (P < 0.01) of embodiment group and comparative example four groups.

Claims (6)

1. the medicine treating monilial vaginitis, it is characterised in that include medicine for external use and oral medicine.

2. a kind of medicine treating monilial vaginitis according to claim 1, it is characterized in that, described Spartina alterniflora's extract 30��40 parts, Herba Leonuri extract 6-8 part, 115��125 parts of suppository base material, suppository base material is semi-synthetic fatty acid glyceride.

3. a kind of medicine treating monilial vaginitis according to claim 1, it is characterized in that, the processing technology of the extract of described Spartina alterniflora is 1) by the Spartina alterniflora after vacuum drying, pulverizer is pulverized and obtains Spartina alterniflora's powder, Spartina alterniflora, powder are placed in the extraction kettle of supercritical extraction; 2) use supercritical CO 2 as solvent, concentration be 60% ethanol do entrainer; 3) regulating extraction kettle extracting pressure to be controlled at 20��35MPa, temperature controls at 35 DEG C, and CO2 flow-control is at 9L/h, and extraction time controls at 2h, obtains brown paste Spartina alterniflora's extract.

4. a kind of medicine treating monilial vaginitis according to claim 1, it is characterised in that described oral medicine includes: Fructus Tritici aestivi, Fructus Maydis, Herba Pteridis Multifidae, Poria, Cortex Phellodendri, Rhizoma Chuanxiong.

5. a kind of medicine treating monilial vaginitis according to claim 2, it is characterised in that described oral medicine technique is:

(1) 11 portions of Fructus Tritici aestivis, 11 parts of Fructus Maydiss, 21 parts of Herba Pteridis Multifidaes, 18 parts of Poria, 11 parts of Cortex Phellodendris, 9 parts of Rhizoma Chuanxiong mixing are carried out Crushing of Ultrafine, and sieve with the screen cloth of 10 orders, discard thick raw material and form raw material; Add water Homogeneous phase mixing carry out homogenizing by 20 MPas of homogenizers, then carries out spray drying, obtains powdered granule;

(2) above-mentioned powdered granule adding 18 parts of distillation hydro-thermals to 70-75 DEG C, the cellulase being subsequently adding 0007 part carries out enzymolysis, and in this process, temperature maintains 70-75 DEG C,

100 minutes persistent period, obtain enzymolysis solution; It is brought rapidly up to 100 DEG C and keeps 5 minutes, being then cooled to rapidly 65-70 DEG C, and passing sequentially through five homogenizers and carry out homogenizing, then carrying out spray drying, finally obtain powdered granule.

6. the medicine of a kind for the treatment of monilial vaginitis according to claim 2, it is characterised in that five described homogenizer pressure are respectively as follows: 30 MPas, 65 MPas, 55 MPas, 40 MPas, 65 MPas.